Radiosensitizer

Name	AC	CK
Curcumin	25	31
Gold (nanoparticles)	19	23
Vitamin C	3	13
Beta-Elemene	10	12
EGCG (Epigallocatechin gallate)	2	11
Resveratrol	7	8
Quercetin	5	7
Crocin	2	6
Genistein	6	6
Thymoquinone	4	6
Fenugreek	1	5
Berberine	3	4
Ginsenosides	3	4
Melatonin	4	4
Tanshinone IIA	3	4
Betulinic acid	3	3
Bromelain	2	3
Cannabidiol	2	3
Ellagic Acid	3	3
Honokiol	2	3
Oridonin	3	3
Polyphenols	2	3
Seaweed: Brown	2	3
Alpha-Lipoic Acid	2	2
Apigenin	1	2
Berbamine	1	2
Blueberry	2	2
Caffeic acid phenethyl ester	2	2
Crocetin	1	2
Delta-tetrahydrocannabinol (THC)	1	2
Kaempferol	1	2
Mistletoe	1	2
Modified Arabinoxylan Rice Bran (MGN-3)	1	2
Myricetin	1	2
Parthenolide	1	2
Peanut	1	2
Silibinin	1	2
Tangeretin	1	2
Turmeric	2	2
Ursolic Acid	2	2
acetyl-11-keto-beta-boswellic acid	1	2
2-Methoxyestradiol	1	1
6-Shogaol	1	1
Allicin	1	1
Aloe Vera	1	1
Artemisinin	1	1
Artesunate	1	1
Astaxanthin	1	1
Baicalein	1	1
Biochanin A	1	1
Bisdemethoxycurcumin	1	1
Cannabis	1	1
Catechin	1	1
Coenzyme Q10	1	1
Cordyceps sinensis	1	1
Curcuminoids	1	1
Deguelin	1	1
Diosmetin	1	1
Emodin	1	1
Ferulic acid	1	1
Flavonoids	1	1
Fucoidan	1	1
Gingerol	1	1
Green Tea	1	1
Holy Basil	1	1
Huaier (Trametes robiniophila murr)	1	1
Isothiocyanates	1	1
Licorice	1	1
Luteolin	1	1
Magnolol	1	1
Mangiferin	1	1
Modified Citrus Pectin	1	1
Moringa oleifera	1	1
Mung Bean	1	1
Nexrutine (Phellodendrom)	1	1
Nicotinamide	1	1
Oleuropein	1	1
Paeonol	1	1
Piperidines	1	1
Piperine	1	1
Piperlongumine	1	1
Pterostilbene	1	1
Reishi Mushroom	1	1
Rosemaric Acid	1	1
Rutin	1	1
Seaweed	1	1
Silymarin	1	1
Spinach	1	1
Stilbenes	1	1
Sulforaphane	1	1
Sweet Cherry	1	1
Tetrahydrocurcumin	1	1
Venom: Toad	1	1
Vitamin E	1	1
Vitamin K2	1	1
Vitexins	1	1
Watercress	1	1
Xanthohumol	1	1
Zataria multiflora	1	1
beta-Carotene	1	1

[+]

Hyperbaric oxygenation for tumour sensitisation to radiotherapy.Jan 10, 2018

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Pubmed Data : Cochrane Database Syst Rev. 2018 04 11 ;4:CD005007. Epub 2018 Apr 11. PMID: 29637538

Article Published Date : Jan 10, 2018

Study Type : Meta Analysis, Review

Additional Links

Diseases : Head and Neck Cancer

Therapeutic Actions : Hyperbaric Treatment

Pharmacological Actions : Radiosensitizer

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Hyperbaric oxygen therapy with chemotherapy was a feasible and promising treatment modality for patients with glioblastoma.Nov 16, 2016

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Pubmed Data : J Radiat Res. 2016 Nov 17. Epub 2016 Nov 17. PMID: 27864508

Article Published Date : Nov 16, 2016

Study Type : Human Study

Additional Links

Diseases : Glioblastoma

Therapeutic Actions : Hyperbaric Treatment

Pharmacological Actions : Chemotherapeutic, Radiosensitizer

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Crocin can be considered as a potential drug and sensitizer in cancer treatment. Dec 31, 2016

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Pubmed Data : Iran J Pharm Res. 2017 ;16(1):230-237. PMID: 28496478

Article Published Date : Dec 31, 2016

Study Type : Human In Vitro

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Substances : Crocin

Diseases : Head and Neck Cancer

Pharmacological Actions : Radiosensitizer

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Fenugreek extract can significantly enhance radiation induced apoptosis. Jun 30, 2015

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Pubmed Data : J Med Signals Sens. 2015 Jul-Sep;5(3):176-81. PMID: 26284174

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Pubmed Data : Curr Issues Mol Biol. 2023 Oct 12 ;45(10):8309-8320. Epub 2023 Oct 12. PMID: 37886967

Article Published Date : Oct 11, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Glioblastoma

Therapeutic Actions : Hyperbaric Treatment

Pharmacological Actions : Chemotherapeutic, Radiosensitizer

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Paeoniflorin in combination with radiation may be a powerful strategy for gastric cancer therapy.Dec 12, 2023

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Pubmed Data : Cancer Res. 2015 Jun 16. Epub 2015 Jun 16. PMID: 26081808

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Pubmed Data : PLoS One. 2018 ;13(7):e0198627. Epub 2018 Jul 3. PMID: 29969452

Article Published Date : Dec 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : acetyl-11-keto-beta-boswellic acid

Diseases : Glioblastoma

Pharmacological Actions : Antiproliferative , Radiosensitizer

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Crocetin extracted from saffron shows antitumor effects in models of human glioblastoma.Jan 08, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2020 Jan 9 ;21(2). Epub 2020 Jan 9. PMID: 31936544

Article Published Date : Jan 08, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Crocetin

Diseases : Glioblastoma

Pharmacological Actions : Apoptotic, Radiosensitizer

Additional Keywords : Natural Substances Versus Drugs, Superiority of Natural Substances versus Drugs

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Pubmed Data : Nanomedicine (Lond). 2013 Oct ;8(10):1601-9. Epub 2012 Dec 24. PMID: 23265347

Article Published Date : Sep 30, 2013

Study Type : Animal Study

Additional Links

Substances : Gold (nanoparticles)

Diseases : Glioma

Pharmacological Actions : Radiosensitizer

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In vitro and in vivo superior radiosensitizing effect of berbamine for head and neck squamous cell carcinoma.Dec 31, 2017

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Pubmed Data : PLoS One. 2017 ;12(1):e0169204. Epub 2017 Jan 12. PMID: 28081154

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Pubmed Data : Cancer Nanotechnol. 2016 ;7(1):8. Epub 2016 Aug 3. PMID: 27867425

Article Published Date : Dec 31, 2015

Study Type : Review

Additional Links

Substances : Gold (nanoparticles)

Pharmacological Actions : Radiosensitizer

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A variety of natural substances may function as novel anticancer agents, proteasome inhibitors and chemosensitizers. Dec 01, 2006

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Pubmed Data : Drug Resist Updat. 2006 Dec;9(6):263-73. Epub 2007 Jan 2. PMID: 17197231

Apigenin enhanced radiation-induced apoptosis/necrosis by sensitization of LNCaP prostate cancer cells.Nov 30, 2021

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Pubmed Data : Cell J. 2021 Dec ;23(7):730-735. Epub 2021 Dec 29. PMID: 34979061

Article Published Date : Nov 30, 2021

Study Type : In Vitro Study

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Substances : Apigenin

Diseases : Prostate Cancer

Pharmacological Actions : Radiosensitizer

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Artesunate enhances radiosensitivity of esophageal cancer cells by inhibiting the repair of DNA damageSep 30, 2018

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Pubmed Data : Front Biosci (Landmark Ed). 2019 Jun 1 ;24:1190-1202. Epub 2019 Jun 1. PMID: 31136975

Article Published Date : May 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Liver Cancer

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Radiosensitizer

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Berberine enhances the sensitivity of radiotherapy in ovarian cancer cell line (SKOV-3).Dec 31, 2022

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Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:258425. Epub 2013 Jun 26. PMID: 23878592

Article Published Date : Dec 31, 2012

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Pubmed Data : Int J Breast Cancer. 2015 ;2015:139349. Epub 2015 Nov 26. PMID: 26693354

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Pubmed Data : Interdiscip Toxicol. 2014 Jun ;7(2):85-8. Epub 2014 Nov 15. PMID: 26109883

Curcumin sensitizes human HCC cells to radiation via the suppression of radiation-induced NF-κB activity.Dec 31, 2014

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Pubmed Data : Cancer Biother Radiopharm. 2008 Jun ;23(3):355-62. PMID: 18593368

Article Published Date : May 31, 2008

Study Type : In Vitro Study

Additional Links

Substances : Deguelin

Diseases : Breast Cancer, Breast Cancer: Triple Negative , Cancers: Drug Resistant

Pharmacological Actions : Apoptotic, Cell cycle arrest, Radiosensitizer

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Evaluation of the radiosensitizing potency of bromelain for radiation therapy of 4T1 breast cancer cells.Dec 31, 2018

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Genistein acts as a radiosensitizing and chemosensitizing agent against the breast cancer cell line MCF-7. Aug 01, 2009

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Pubmed Data : Anticancer Res. 2009 Aug;29(8):3179-83. PMID: 19661332

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Pubmed Data : Oncotarget. 2016 Mar 26. Epub 2016 Mar 26. PMID: 27029077

Article Published Date : Mar 25, 2016

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Radiosensitizer

Additional Keywords : Gene Expression Regulation, Selective Cytotoxicity

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Ginsenoside Rg3 sensitizes human non-small cell lung cancer cells to γ-radiation by targeting the nuclear factor-κB pathway.Jun 30, 2015

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Pubmed Data : J Nat Prod. 2020 May 22 ;83(5):1461-1472. Epub 2020 Apr 29. PMID: 32347726

Article Published Date : May 21, 2020

Study Type : In Vitro Study

Additional Links

Substances : Licorice

Diseases : Cancers: All, Cancers: Multi-Drug Resistant

Pharmacological Actions : Radiosensitizer

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Limonin enhances the radiosensitivity of nasopharyngeal carcinoma cells.Sep 30, 2019

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Pubmed Data : Biomed Pharmacother. 2019 Oct ;118:109366. Epub 2019 Aug 23. PMID: 31545261

Article Published Date : Sep 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Citrus Triterpenoids

Diseases : Nasopharyngeal Cancer

Pharmacological Actions : Radiosensitizer

Additional Keywords : Cancer Stem Cells

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Low-dose gambogic acid may be a potential radionuclide sensitizer.Jul 31, 2021

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Pubmed Data : Oncol Rep. 2018 Oct 1. Epub 2018 Oct 1. PMID: 30272350

Article Published Date : Sep 30, 2018

Study Type : In Vitro Study

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Substances : Mangiferin

Diseases : Glioblastoma

Pharmacological Actions : Radiosensitizer

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Melatonin can enhance the cell-killing effect of X-ray irradiation at low concentration.Jun 30, 2019

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Pubmed Data : Dose Response. 2019 Jul-Sep;17(3):1559325819877271. Epub 2019 Sep 23. PMID: 31579126

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Pubmed Data : Radiat Oncol. 2016 Nov 22 ;11(1):153. Epub 2016 Nov 22. PMID: 27876069

Article Published Date : Nov 21, 2016

Study Type : In Vitro Study

Additional Links

Substances : Spinach

Diseases : Pancreatic Cancer

Pharmacological Actions : Apoptotic, Radiosensitizer

Additional Keywords : Plant Extracts

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Click here to read the entire abstract

Pubmed Data : Int J Gynecol Cancer. 2012 Jun ;22(5):718-24. PMID: 22552829

Article Published Date : May 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Artemisinin

Diseases : Cervical Cancer

Pharmacological Actions : Apoptotic, Cell cycle arrest, Radiosensitizer

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Silibinin radiosensitizes EGF receptor-knockdown prostate cancer cells.Sep 29, 2022

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Pubmed Data : Clin Transl Oncol. 2023 Mar 25. Epub 2023 Mar 25. PMID: 36964888

Article Published Date : Mar 24, 2023

Study Type : In Vitro Study

Additional Links

Substances : Chrysin

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Apoptotic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Radiosensitizer

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Synergistic tumoricidal effects of alpha-lipoic acid and radiotherapy on human breast cancer cells via HMGB1.Dec 14, 2020

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Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(16):7285-90. PMID: 26514525

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Zataria multiflora

Diseases : Glioblastoma

Pharmacological Actions : Antiproliferative , Apoptotic, Radiosensitizer

Additional Keywords : Phytotherapy, Plant Extracts

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These findings indicate that the fisetin-induced ER stress can overcome radioresistance and induce cell death in liver cancer cells.May 21, 2023

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Pubmed Data : Int J Mol Sci. 2023 May 22 ;24(10). Epub 2023 May 22. PMID: 37240422

Article Published Date : May 21, 2023

Study Type : In Vitro Study

Additional Links

Substances : Fisetin

Diseases : Lipopolysaccharide-Induced Toxicity, Liver Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Radiosensitizer

Additional Keywords : Tumor Microenvironment

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These findings support the potential prophylactic impact of watercress during radiotherapy.Jul 30, 2018

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Pubmed Data : Front Pharmacol. 2017 ;8:295. Epub 2017 Jun 12. PMID: 28659794

Article Published Date : Dec 31, 2016

Study Type : Review

Additional Links

Substances : Thymoquinone

Diseases : Cancers: All

Pharmacological Actions : Chemosensitizer, Chemotherapeutic, Radiosensitizer

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Thymoquinone is a promising agent in the treatment of head and neck cancer due to its anti-proliferative and radiosensitizing properties.Jun 30, 2017

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Pubmed Data : Invest New Drugs. 2021 Oct 6. Epub 2021 Oct 6. PMID: 34613571

Article Published Date : Oct 05, 2021

Study Type : In Vitro Study

Additional Links

Diseases : Head and Neck Cancer, Skin Cancer: Squamous Cell

Pharmacological Actions : Apoptotic, Radiosensitizer

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β-elemene enhances the radiosensitivity of gastric cancer cells by inhibiting Pak1 activation.Sep 13, 2015

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View the Evidence: 238 Abstracts with Radiosensitizer Research

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Hyperbaric oxygenation for tumour sensitisation to radiotherapy.Jan 10, 2018

Hyperbaric oxygen therapy with chemotherapy was a feasible and promising treatment modality for patients with glioblastoma.Nov 16, 2016

Pharmacological ascorbate reduces radiation-induced normal tissue toxicity and enhances tumor radiosensitization in pancreatic cancer.Sep 24, 2018

Selaginella may induce radiosensitization on nasopharyngeal carcinoma and may reduce acute toxicity to healthy tissue..Feb 01, 2006

Tea polyphenol has potential to be a therapeutic adjuvant against human metastatic breast cancer.Feb 01, 2012

This study indicates the feasibility of combining hyperbaric oxygen with chemoradiation.Feb 28, 2017

Crocin can be considered as a potential drug and sensitizer in cancer treatment. Dec 31, 2016

Fenugreek extract can significantly enhance radiation induced apoptosis. Jun 30, 2015

Astaxanthin synergizes with ionizing radiation in oral squamous cell carcinoma.Dec 15, 2023

Cordycepin enhances radiosensitivity to induce apoptosis through cell cycle arrest, caspase pathway and ER stress in MA-10 mouse Leydig tumor cells.Dec 31, 2021

Hyperbaric oxygen therapy adjuvant chemotherapy and radiotherapy through inhibiting stemness in glioblastoma.Oct 11, 2023

Paeoniflorin in combination with radiation may be a powerful strategy for gastric cancer therapy.Dec 12, 2023

3,3'-diindolylmethane enhances tumor regression after radiation.Dec 31, 2020

A nanoformulation of curcumin induced apoptosis in THP-1 cells via caspase-3 activation.Jul 28, 2016

Andrographolide radiosensitizes human ovarian cancer SKOV3 xenografts due to an enhanced apoptosis and autophagy.Oct 31, 2015

Apigenin may improve the radiosensitivity of laryngeal carcinoma by suppressing the expression of GLUT-1 via the PI3K/Akt pathway.Jul 27, 2015

Arabinoxylan rice bran (MGN-3/Biobran) enhances radiotherapy in animals bearing Ehrlich ascites carcinoma.Aug 28, 2019

Ascorbate combined with ionizing radiation decreased tumor growth and increased survival, without damaging the gastrointestinal tract.Jun 15, 2015

Breast cancer suppression by curcumin-naringenin-magnetic-nano-particles: In vitro and in vivo studies.Dec 31, 2020

Cannabinoids can prime glioma cells to respond better to ionizing radiation and suggest a potential clinical benefit for glioma patients by using these two treatment modalities.Nov 30, 2014

Combined acetyl-11-keto-β-boswellic acid and radiation treatment inhibited glioblastoma tumor cellsDec 31, 2017

Crocetin extracted from saffron shows antitumor effects in models of human glioblastoma.Jan 08, 2020

Curcumin had a radiosensitizing effect on nasopharyngeal carcinoma cells in vivo and in vitro.May 31, 2016

Curcumin has anticancer, chemosensitization and radiosensitization effects in prostate cancer.Mar 01, 2007

Curcumin is a potential radio-enhancer in head and neck cancer.Oct 01, 2009

Curcumin prevents radiation-induced activation of the NF-κΒ pathway and is a promising way to improve the antitumor efficacy of ionizing radiation.Dec 31, 2012

Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation. Apr 01, 2008

Down-regulation of survivin and hypoxia-inducible factor-1 α by β-elemene enhances the radiosensitivity of lung adenocarcinoma xenograft.Jan 31, 2012

Downregulation of peroxiredoxin-1 by β-elemene enhances the radiosensitivity of lung adenocarcinoma xenografts.Feb 28, 2015

Ginsenoside Rg3 enhances the antitumor effects of radiotherapy for colorectal cancerDec 31, 2017

Gold nanoparticle hyperthermia reduces radiotherapy dose.Oct 31, 2014

Gold nanoparticles of the correct size can be used to enhance the effects of irradiation in the context of a glioma model.Sep 30, 2013

Gold radiation enhancement significantly improved long-term survival compared with radiotherapy alone. Sep 30, 2013

In vitro and in vivo superior radiosensitizing effect of berbamine for head and neck squamous cell carcinoma.Dec 31, 2017

Kaempferol increased tumor cell killing by radiation in vitro and in vivo through inhibition of the AKT/PI3K and ERK pathways and activation of the mitochondria apoptosis pathwayAug 18, 2015

Liposomal-naringenin radiosensitizes triple-negative breast cancer MDA-MB-231 cells.Dec 31, 2023

Mistletoe-based drugs work in synergy with radio-chemotherapy in the treatment of glioma.Dec 31, 2018

Myricetin could be a potential radiosensitizer for lung cancer therapy.Mar 19, 2014

Oleanolic acid combined with olaparib enhances radiosensitization in triple negative breast cancer and hypoxia.Apr 24, 2022

Parthenolide selectively sensitizes prostate tumor tissue to radiotherapy while protecting healthy tissues in vivo.Apr 30, 2017

Piperlongumine conquers temozolomide chemoradiotherapy resistance to achieve immune cure in refractory glioblastoma.May 09, 2023

Quercetin is a potent radiosensitizer for medulloblastoma cells that may be a promising lead for the treatment of medulloblastoma in patients.Mar 07, 2016

Quercetin pretreatment enhances the radiosensitivity of colon cancer cells by targeting Notch-1 pathway.Jan 17, 2020

Seaweed polyphenols may inhibit pancreatic cancer relapse/recurrence by targeting therapy-orchestrated stem-cell signaling in residual cells.Dec 31, 2014

Silibinin strongly radiosensitized DU145 tumor xenografts with higher apoptotic response and reduced repair of DNA damage.Nov 30, 2015

Study of the radiosensitizing and radioprotective efficacy of bromelain.Dec 31, 2019

Tangeretin almost completely inhibited lung metastasis induced by irradiation in this study. May 14, 2015

Tanshinone sensitized the antitumor effects of irradiation on laryngeal cancer via JNK pathway.Sep 30, 2018

Targeted gold nanoparticles enhance the sensitization of prostate tumors to megavoltage radiation therapy.Jun 30, 2015

Targeting survivin using honokiol in combination with radiation therapy may provide novel therapeutic opportunities.Feb 14, 2018

The study expands the understanding of the pharmacological properties of berberine and its applicability as a radiosensitizer towards treating liver cancer.Nov 30, 2020

These results demonstrate the promising synergistic effect of resveratrol and peanut stem extract combined with radiation in the treatment of radioresistant PCa.Dec 31, 2016

Thymoquinone enhances the effect of Gamma Knife in B16-F10 melanoma through inhibition of p-STAT3.Apr 30, 2019

Thymoquinone has beneficial effects as an effective radioprotective candidate that enhances cellular immunity.Feb 14, 2016

Oridonin enhances the radiosensitivity of lung cancer cells by upregulating Bax and downregulating Bcl-2.Nov 30, 2018

"Resveratrol enhances prostate cancer cell response to ionizing radiation."Jan 01, 2011

2-Methoxyestradiol, an endogenous estrogen metabolite, sensitizes radioresistant breast cancer cells through multiple mechanisms.Apr 30, 2011

6-Gingerol enhances the radiosensitivity of gastric cancer cells.Apr 30, 2018

6-shogaol induces apoptosis and enhances radiosensitivity in head and neck squamous cell carcinoma cell lines.Nov 22, 2017

A gold nanoparticle system for the enhancement of radiotherapy and simultaneous monitoring of reactive-oxygen-species formation.Sep 18, 2018

A number of plant polyphenols have chemosensitizing and radiosensitizing activity. Nov 01, 2005

A review of gold nanoparticles and their radiosensitisation capabilities.Dec 31, 2015

A variety of natural substances may function as novel anticancer agents, proteasome inhibitors and chemosensitizers. Dec 01, 2006

Allicin enhances the radiosensitivity of colorectal cancer cells.May 31, 2020

Aloe polysaccharide induces autophagy in pancreatic carcinoma BxPC-3 cells both alone and in concert with radiation.Jun 30, 2016

Alpha-lipoic acid prevents the ionizing radiation-induced epithelial-mesenchymal transition and enhances the radiosensitivity in breast cancer cells.Mar 14, 2020

An ultrasound-assisted extract of sweet cherry seemed to act as a radioprotector at lower doses and a radiosensitizer at higher doses. Feb 28, 2018

Anti-cancer agent: the labdane diterpenoid-andrographolide. May 11, 2023

Apigenin enhanced radiation-induced apoptosis/necrosis by sensitization of LNCaP prostate cancer cells.Nov 30, 2021

Artesunate enhances radiosensitivity of esophageal cancer cells by inhibiting the repair of DNA damageSep 30, 2018

Astaxanthin increases radiosensitivity in esophageal squamous cell carcinoma.May 31, 2017

Augmentation of radiation-induced apoptosis by ellagic acid.Feb 28, 2010

Radiosensitizer

View the Evidence:
238 Abstracts with Radiosensitizer Research