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41 Substances Researched for Secretagogue
NameACCKFocus
Melatonin322Locked
GABA (gamma-Aminobutyric Acid)220Locked
Arginine414Locked
Fat: All110Locked
Magnesium110Locked
Natto 110Locked
Progesterone110Locked
Vitamin A110Locked
Vitamin K110Locked
Whey110Locked
Pantothenic Acid (Vitamin B-5)24Locked
Genistein23Locked
Angelica12Locked
Biochanin A12Locked
Cholesterol 12Locked
Cnidium 12Locked
Daidzein12Locked
Fenugreek12Locked
Formononetin12Locked
Ginsenosides12Locked
Milk Thistle12Locked
Panax Ginseng12Locked
Peony12Locked
Poria cocos12Locked
Seaweed: Brown 12Locked
Suma (Pfaffia Paniculata)12Locked
Testosterone22Locked
Tongkat Ali12Locked
Vitamin B-612Locked
phytoestrogens12Locked
Curcumin11Locked
Cysteine (see N-Acetylcysteine)11Locked
Flowers11Locked
Garlic11Locked
Ginkgo biloba11Locked
Ginseng11Locked
Lysine11Locked
Pycnogenol (Pine Bark)11Locked
Sesamol11Locked
Soy11Locked
Unspecified Species11Locked

View the Evidence:
38 Abstracts with Secretagogue Research

[+]

"Growth Hormone Responses to Consecutive Exercise Bouts with Ingestion of Carbohydrate plus Protein."Nov 18, 2012

Pubmed Data : Int J Sport Nutr Exerc Metab. 2012 Nov 19. Epub 2012 Nov 19. PMID: 23307404
Article Published Date : Nov 18, 2012
Study Type : Human Study
Additional Links
Substances : Whey
Diseases : Human Growth Hormone: Enhancement, Low Human Growth Hormone
Therapeutic Actions : Exercise
Pharmacological Actions : Secretagogue
[+]

Arginine and ornithine supplementation increases growth hormone and insulin-like growth factor-1 serum levels after heavy-resistance exercise in strength-trained athletes.Apr 01, 2010

Pubmed Data : J Strength Cond Res. 2010 Apr;24(4):1082-90. PMID: 20300016
Article Published Date : Apr 01, 2010
Study Type : Human Study
Additional Links
Substances : Arginine
Diseases : Athletic Performance, Insulin-Like Growth Factor (IGF): Low, Low Human Growth Hormone
Pharmacological Actions : Secretagogue
Additional Keywords : Strength Training
[+]

GABA significantly increases indicators of Human Growth Hormone production in human subjects. - Article 2Feb 01, 1980

Pubmed Data : Acta Endocrinol (Copenh). 1980 Feb;93(2):149-54. PMID: 7376786
Article Published Date : Feb 01, 1980
Study Type : Human Study
Additional Links
Substances : GABA (gamma-Aminobutyric Acid)
Diseases : Human Growth Hormone: Enhancement
Pharmacological Actions : Secretagogue
[+]

GABA significantly increases indicators of Human Growth Hormone production in human subjects.- Article 1Jan 01, 2008

Pubmed Data : Med Sci Sports Exerc. 2008 Jan;40(1):104-10. PMID: 18091016
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Substances : GABA (gamma-Aminobutyric Acid)
Diseases : Human Growth Hormone: Enhancement
Pharmacological Actions : Secretagogue
[+]

High intake of fat is associated with higher serum levels of estrone and DHEAS in postmenopausal women.Dec 01, 2005

Pubmed Data : J Nutr. 2005 Dec;135(12):2862-5. PMID: 16317133
Article Published Date : Dec 01, 2005
Study Type : Human Study
Additional Links
Substances : Fat: All
Diseases : DHEA: Low, Estrogen Deficiency, Estrone: Too Low, Hormone Insufficency, Postmenopausal Disorders
Pharmacological Actions : Secretagogue
[+]

Intake of fermented soybean (natto) increases circulating vitamin K2 and osteocalcin (a marker for bone formation) in normal individuals. Jan 01, 2000

Pubmed Data : J Bone Miner Metab. 2000;18(4):216-22. PMID: 10874601
Article Published Date : Jan 01, 2000
Study Type : Human Study
Additional Links
Substances : Natto , Vitamin K
Diseases : Osteoporosis
Pharmacological Actions : Secretagogue
[+]

Magnesium levels are strongly and independently associated with the anabolic hormones testosterone and IGF-1.Nov 01, 2002

Pubmed Data : Clin Exp Rheumatol. 2002 Nov-Dec;20(6):767-71. PMID: 21675994
Article Published Date : Nov 01, 2002
Study Type : Human Study
Additional Links
Substances : Magnesium
Diseases : Insulin-Like Growth Factor (IGF): Low, Testosterone: Too Low
Pharmacological Actions : Anabolic Agents, Secretagogue
[+]

Meditation results in acute increases in night-time plasma melatonin levels.May 01, 2000

Pubmed Data : Biol Psychol. 2000 May;53(1):69-78. PMID: 10876066
Article Published Date : May 01, 2000
Study Type : Human Study
Additional Links
Substances : Melatonin
Diseases : Hormone Imbalances: Low Melatonin
Pharmacological Actions : Secretagogue
[+]

Progesterone prevents sleep disturbances and modulates GH, TSH, and melatonin secretion in postmenopausal women.Feb 02, 2011

Pubmed Data : J Clin Endocrinol Metab. 2011 Feb 2. Epub 2011 Feb 2. PMID: 21289261
Article Published Date : Feb 02, 2011
Study Type : Human Study
Additional Links
Substances : Progesterone
Diseases : Human Growth Hormone: Enhancement, Inappropriate Growth Hormone Secretion Syndrome, Inappropriate TSH Secretion Syndrome, Low Human Growth Hormone, Postmenopausal Disorders, TSH: Elevated
Pharmacological Actions : Secretagogue
[+]

Short-term exercise produces an elevation in serum testosterone levels in young adults.Mar 31, 2014

Pubmed Data : Indian J Physiol Pharmacol. 2014 Apr-Jun;58(2):178-81. PMID: 25509972
Article Published Date : Mar 31, 2014
Study Type : Human Study
Additional Links
Diseases : Testosterone: Too Low
Therapeutic Actions : Exercise
Pharmacological Actions : Secretagogue
[+]

Transcranial magnetotherapy (TcMT) and electric stimulation (ES) improve erectile dysfunction in obese patients. Sep 01, 2009

Pubmed Data : Vopr Kurortol Fizioter Lech Fiz Kult. 2009 Sep-Oct(5):30-3. PMID: 19886019
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Diseases : Erectile Dysfunction, Low Testosterone
Therapeutic Actions : Electric Stimulation , Magnet Therapy
Pharmacological Actions : Secretagogue
[+]

Vitamin A supplementation increases progesterone levels during pregnancy.Jan 01, 1991

Pubmed Data : Int J Vitam Nutr Res. 1991;61(1):17-9. PMID: 1856040
Article Published Date : Jan 01, 1991
Study Type : Human Study
Additional Links
Substances : Vitamin A
Diseases : Progesterone: Low
Pharmacological Actions : Secretagogue
[+]

Warming up breasts by a breast compress is easy and affordable, and this procedure increases the amount of breastmilk. Mar 16, 2012

Pubmed Data : Breastfeed Med. 2012 Mar 16. Epub 2012 Mar 16. PMID: 22424466
Article Published Date : Mar 16, 2012
Study Type : Human Study
Additional Links
Diseases : Breast Milk: Inadequate/Poor Quality, Lactation Disorders
Therapeutic Actions : Warming Compresses
Pharmacological Actions : Galactogogue, Secretagogue
[+]

Yogic practices can be used as psychophysiologic stimuli to increase endogenous secretion of melatonin, which, in turn, might be responsible for improved sense of well-being.Apr 01, 2004

Pubmed Data : J Altern Complement Med. 2004 Apr;10(2):261-8. PMID: 15165407
Article Published Date : Apr 01, 2004
Study Type : Human Study
Additional Links
Substances : Melatonin
Pharmacological Actions : Secretagogue
[+]

A mixture of asian herbs increases progesterone secretion in female rats.Jan 01, 1991

Pubmed Data : Am J Chin Med. 1991;19(1):57-60. PMID: 1897491
Article Published Date : Jan 01, 1991
Study Type : Animal Study
Additional Links
Substances : Angelica, Cnidium , Peony, Poria cocos
Diseases : Progesterone: Low
Pharmacological Actions : Secretagogue
[+]

Arginine supplementation increases progesterone levels in female sheep. Oct 15, 2008

Pubmed Data : Pak J Biol Sci. 2008 Oct 15;11(20):2389-94. PMID: 19137847
Article Published Date : Oct 15, 2008
Study Type : Animal Study
Additional Links
Substances : Arginine
Diseases : Progesterone: Low
Pharmacological Actions : Secretagogue
[+]

Brown kelp exhibits anti-estrogenic activity and mildly increases progesterone levels in female rats.Feb 01, 2005

Pubmed Data : J Nutr. 2005 Feb;135(2):296-300. PMID: 15671230
Article Published Date : Feb 01, 2005
Study Type : Animal Study
Additional Links
Substances : Seaweed: Brown
Diseases : Estrogen Dominance, Progesterone: Low
Pharmacological Actions : Secretagogue
Additional Keywords : Hormone Dependent Cancers
[+]

Cholesterol stimulates progesterone production in cows, regardless of the lipoprotein type from which it is sourced.Feb 23, 2010

Pubmed Data : Biochim Biophys Acta. 2010 Feb 23. Epub 2010 Feb 23. PMID: 1401371
Article Published Date : Feb 23, 2010
Study Type : Animal Study
Additional Links
Substances : Cholesterol
Diseases : Progesterone: Low
Pharmacological Actions : Secretagogue
[+]

Fenugreek seeds increase rat growth hormone from rat pituitary cells.Jan 01, 2007

Pubmed Data : J Food Sci. 2007 Jan;72(1):S055-8. PMID: 18816528
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Substances : Fenugreek
Diseases : Human Growth Hormone: Enhancement
Pharmacological Actions : Secretagogue
Additional Keywords : Human Growth Hormone
[+]

Ginsenoside Rg1, a compound found within ginseng, improves male copulatory behavior in mice. Sep 14, 2009

Pubmed Data : J Sex Med. 2009 Sep 14. Epub 2009 Sep 14. PMID: 19751391
Article Published Date : Sep 14, 2009
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Erectile Dysfunction, Low Libido, Low Testosterone
Pharmacological Actions : Aphrodisiac , Nitric Oxide Enhancer, Secretagogue
[+]

Panax ginseng contains a compound, ginsenoside-Rb1, which increases the secretion of luteinizing hormone in male rats. Mar 31, 2003

Pubmed Data : Chin J Physiol. 2003 Mar 31;46(1):1-7. PMID: 12817698
Article Published Date : Mar 31, 2003
Study Type : Animal Study
Additional Links
Substances : Panax Ginseng
Diseases : Inappropriate Luteinizing Hormone Secretion
Pharmacological Actions : Secretagogue
[+]

Panthothenic acid stimulates the adrenal cells in male rats to secrete corticosterone and progesterone. Jun 01, 2008

Pubmed Data : Biol Pharm Bull. 2008 Jun;31(6):1205-8. PMID: 18520055
Article Published Date : Jun 01, 2008
Study Type : Animal Study
Additional Links
Substances : Pantothenic Acid (Vitamin B-5)
Diseases : Adrenal Insufficiency , Progesterone: Low
Pharmacological Actions : Secretagogue
[+]

Pantothenic acid improves testosterone, corticosterone and testicular function in male rats. Nov 01, 2009

Pubmed Data : J Vet Med Sci. 2009 Nov;71(11):1427-32. PMID: 19959891
Article Published Date : Nov 01, 2009
Study Type : Animal Study
Additional Links
Substances : Pantothenic Acid (Vitamin B-5)
Diseases : Corticosterone Deficiency, Infertility: Male, Low Testosterone, Sperm Quality: Low, Testicular Diseases
Pharmacological Actions : Secretagogue
[+]

Phytoestrogens can stimulate testosterone synthesis during puberty in male goats by increasing the secretion of T3; a hormone known to stimulate Leydig cell steroidogenesis.Dec 10, 2009

Pubmed Data : Acta Vet Scand. 2009 Dec 10;51:51. PMID: 20003293
Article Published Date : Dec 10, 2009
Study Type : Animal Study
Additional Links
Substances : Biochanin A, Daidzein, Formononetin, Genistein, phytoestrogens
Diseases : Hypothyroidism, Low Testosterone
Pharmacological Actions : Secretagogue, Steroidogenesis
[+]

Silymarin, a compound found within milk thistle, induces hyperprolactinemia in female rats. Sep 01, 2009

Pubmed Data : Phytomedicine. 2009 Sep;16(9):839-44. Epub 2009 Mar 20. PMID: 19303749
Article Published Date : Sep 01, 2009
Study Type : Animal Study
Additional Links
Substances : Milk Thistle
Diseases : Lactation Disorders
Pharmacological Actions : Secretagogue
[+]

Suma appears to raise levels of sex hormones, as evidenced in mice.Apr 01, 2003

Pubmed Data : J Reprod Dev. 2003 Apr;49(2):175-80. PMID: 14967943
Article Published Date : Apr 01, 2003
Study Type : Animal Study
Additional Links
Substances : Suma (Pfaffia Paniculata)
Diseases : Hormone Insufficency, Hormones: Insufficient Levels, Low Testosterone
Pharmacological Actions : Secretagogue
[+]

Tongkat Ali (Euycoma longifolia) improved sexual performance and testosterone but not motivation in sluggish rats. Nov 12, 2009

Pubmed Data : J Ethnopharmacol. 2009 Nov 12;126(2):308-13. Epub 2009 Aug 22. PMID: 19703544
Article Published Date : Nov 12, 2009
Study Type : Animal Study
Additional Links
Substances : Tongkat Ali
Diseases : Erectile Dysfunction, Low Testosterone, Sexual Dysfunction
Pharmacological Actions : Secretagogue
[+]

Vitamin B6 increases melatonin production. Dec 01, 2007

Pubmed Data : Georgian Med News. 2007 Dec(153):35-8. PMID: 18250494
Article Published Date : Dec 01, 2007
Study Type : Animal Study
Additional Links
Substances : Melatonin, Vitamin B-6
Diseases : Hormone Imbalances: Low Melatonin
Pharmacological Actions : Secretagogue
[+]

Aged garlic, l-arginine, l-lysine, S-allyl cysteine and pycnogenol increase human growth hormone secretion in an in vitro model. Feb 01, 2002

Pubmed Data : Growth Horm IGF Res. 2002 Feb;12(1):34-40. PMID: 12127300
Article Published Date : Feb 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Arginine, Cysteine (see N-Acetylcysteine), Garlic, Lysine, Pycnogenol (Pine Bark)
Diseases : Low Human Growth Hormone
Pharmacological Actions : Secretagogue
[+]

Curcumin inhibits bTREK-1 K+ channels and stimulates cortisol secretion from adrenocortical cells.Jun 13, 2008

Pubmed Data : Biochem Biophys Res Commun. 2008 Jun 13;370(4):623-8. Epub 2008 Apr 10. PMID: 18406348
Article Published Date : Jun 13, 2008
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cortisol: Low
Pharmacological Actions : Secretagogue
[+]

Ginkgo biloba extract enhances testosterone synthesis in type 2 diabetic rats. Apr 01, 2008

Pubmed Data : Zhonghua Nan Ke Xue. 2008 Apr;14(4):371-6. PMID: 18481435
Article Published Date : Apr 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Diabetes Mellitus: Type 2, Low Testosterone
Pharmacological Actions : Secretagogue
[+]

Ginseng flowers stimulate progesterone production in bovine luteal cells.Aug 01, 2006

Pubmed Data : J Toxicol Environ Health A. 2006 Aug;69(15):1481-95. PMID: 11154050
Article Published Date : Aug 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Flowers, Ginseng, Unspecified Species
Diseases : Progesterone: Low
Pharmacological Actions : Secretagogue
Additional Keywords : Plant Extracts
[+]

L-arginine has been shown to increase human growth hormone levels.Jan 01, 2008

Pubmed Data : Curr Opin Clin Nutr Metab Care. 2008 Jan;11(1):50-4. PMID: 18090659
Article Published Date : Jan 01, 2008
Study Type : Review
Additional Links
Substances : Arginine
Diseases : Human Growth Hormone: Enhancement, Low Human Growth Hormone
Pharmacological Actions : Secretagogue
[+]

Music may facilitate neurogenesis, regeneration and repair of neurons.Nov 01, 2008

Pubmed Data : Med Hypotheses. 2008 Nov;71(5):765-9. Epub 2008 Aug 8. PMID: 18692321
Article Published Date : Nov 01, 2008
Study Type : Commentary
Additional Links
Diseases : Brain Injury: Traumatic, Cortisol: Low, Estrogen Deficiency, Testosterone: Too Low
Therapeutic Actions : Music
Pharmacological Actions : Neuritogenic, Secretagogue
[+]

Resistance exercise and training results in the secretion of testosterone. Dec 01, 2010

Pubmed Data : Sports Med. 2010 Dec 1;40(12):1037-53. PMID: 21058750
Article Published Date : Dec 01, 2010
Study Type : Review
Additional Links
Substances : Testosterone
Diseases : Testosterone: Too Low
Therapeutic Actions : Exercise: Resistance Training
Pharmacological Actions : Anabolic Agents, Secretagogue
[+]

Sesamol induces cell death and up-regulates progesterone production in mouse testical tumor cells.Sep 06, 2011

Pubmed Data : J Agric Food Chem. 2011 Sep 6. Epub 2011 Sep 6. PMID: 21863802
Article Published Date : Sep 06, 2011
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Progesterone: Low, Testicular Cancer
Pharmacological Actions : Apoptotic, Secretagogue, Steroidogenesis
[+]

Testosterone has protective effects in Alzheimer's disease. Jul 01, 2009

Pubmed Data : Front Neuroendocrinol. 2009 Jul ;30(2):239-58. Epub 2009 May 7. PMID: 19427328
Article Published Date : Jul 01, 2009
Study Type : Review
Additional Links
Substances : Testosterone
Diseases : Aging
Pharmacological Actions : Neuroprotective Agents, Secretagogue
[+]

The soy compounds genistein and daidzein inhibit the production of cortisol, while increasing the androgen pathway, e.g. DHEA. Apr 01, 2009

Pubmed Data : J Hypertens. 2009 Apr;27(4):774-81. PMID: 10404819
Article Published Date : Apr 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Genistein, Soy
Diseases : High Cortisol, Low Testosterone
Pharmacological Actions : Secretagogue

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