STAT3 Inhibitor

Name	AC	CK
Cucurbitacin B	6	17
Rose	3	13
Silibinin	4	13
Curcumin	9	11
Ginsenosides	5	11
Flavonoids	8	8
Luteolin	5	7
Piperlongumine	5	7
Apigenin	4	6
Honokiol	3	6
Paeoniflorin	4	6
Quercetin	4	6
Salvia miltiorrhiza	4	6
6-Shogaol	4	5
Berberine	4	5
Beta-Elemene	4	5
Magnolol	4	5
Resveratrol	4	5
Thymoquinone	3	5
Artesunate	3	4
Astaxanthin	3	4
Elecampane	4	4
Ginkgo biloba	4	4
Honeysuckle	2	4
Mulberry	4	4
Rosmarinic acid	2	4
Shikonin	3	4
Burdock	2	3
Carnosol	2	3
EGCG (Epigallocatechin gallate)	2	3
Formononetin	2	3
Nexrutine (Phellodendrom)	3	3
Omega-3 Fatty Acids	1	3
Paeonol	2	3
Polyphenols	3	3
Pterostilbene	2	3
Saikosaponin	3	3
Terminalia	1	3
Ursolic Acid	3	3
Xanthohumol	2	3
Andrographolide	1	2
Angelica	1	2
Antrodia camphorata	1	2
Ashwagandha	1	2
Astragalus	1	2
Avocado	1	2
Berbamine	2	2
Beta-Caryophyllene	2	2
Black Pepper	1	2
Cocoa	1	2
Coenzyme Q10	1	2
Cucurbitacin E	1	2
Dandelion	1	2
Diosmin	1	2
Evening Primrose Oil	1	2
Genistein	1	2
Gingerol	2	2
Gynostemma	1	2
Hemp Seed	1	2
Kaempferol	1	2
Licorice	2	2
Lignans	2	2
Lithospermum erythrorhizon	1	2
Long Pepper	1	2
Lycopene	1	2
Maca	1	2
Magnesium	1	2
Mangiferin	2	2
Oleanolic acid	1	2
Oridonin	2	2
Panax Notoginseng	1	2
Parthenolide	2	2
Perilla	1	2
Phloretin	1	2
Piceatannol	1	2
Puerarin	1	2
Punicalagin	2	2
Raspberry	1	2
Red Marine Algae	1	2
Rosemary	2	2
Sage	2	2
Sesame Seeds	2	2
Sesamin	2	2
Stilbenes	1	2
Tanshinone IIA	2	2
Zerumbone	1	2
4-Shogaol	1	1
Alpha-Lipoic Acid	1	1
Andrographis	1	1
Beet	1	1
Bergamot	1	1
Betulinic acid	1	1
Biochanin A	1	1
Bitter Melon	1	1
Blueberry	1	1
Caffeic Acid	1	1
Caffeic acid phenethyl ester	1	1
Capsaicin	1	1
Cardamonin	1	1
Carnosic Acid	1	1
Carvacrol	1	1
Chokeberry	1	1
Chrysanthemum Indicum	1	1
Chrysin	1	1
Crocetin	1	1
Crocin	1	1
Curcumol	1	1
Cyanidin 3-glucoside	1	1
DHA (Docosahexaenoic Acid)	1	1
Dong Quai	1	1
Ellagic Acid	1	1
Fisetin	1	1
Frankincense	1	1
Fucoxanthin	1	1
Gac	1	1
Garlic	1	1
Grapefruit	1	1
Harmine	1	1
Hesperidin	1	1
Isoliquiritigenin	1	1
Lupeol	1	1
Lychee	1	1
Manuka Honey	1	1
Modified Citrus Pectin	1	1
Myricetin	1	1
Myrrh	1	1
Naringenin	1	1
Neem	1	1
Nigella sativa (aka Black Seed)	1	1
Nobiletin	1	1
Phellinus Linteus	1	1
Reishi Mushroom	1	1
Rhubarb	1	1
Rutin	1	1
Tangeretin	1	1
Tocotrienol: Delta	1	1
Vitexins	1	1
Wogonin	1	1

Diseases : Arsenic Poisoning, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-6 Downregulation, STAT3 Inhibitor

Additional Keywords : Phytotherapy

Problem Substances : Arsenic

[+]

Cryptotanshinone attenuated pathological cardiac remodeling. Dec 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Phytomedicine. 2022 Jul 4 ;104:154318. Epub 2022 Jul 4. PMID: 35830757

Article Published Date : Jul 03, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Terminalia

Diseases : Atopic Dermatitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, NF-kappaB Inhibitor, STAT3 Inhibitor

[+]

3, 3'- diindolylmethane hinders IL-17A/IL-17RA interaction and mitigates imiquimod-induced psoriasis.Jul 31, 2022

[+]

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Ginseng Res. 2022 May ;46(3):418-425. Epub 2021 Jul 14. PMID: 35600776

Article Published Date : Apr 30, 2022

Study Type : Animal Study

Additional Links

Substances : Artesunate, Ginsenosides

Diseases : Cancers: Drug Resistant, Liver Cancer

Pharmacological Actions : Chemosensitizer, STAT3 Inhibitor

Additional Keywords : Chemothapeutic Synergy: Sorafenib

[+]

Gynostemma pentaphyllum saponins attenuate inflammation in vitro and in vivo by inhibition of NF-κB and STAT3 signaling.Oct 19, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Pharm. 2018 Jun 1 ;68(2):211-222. PMID: 29702481

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Neoplasia. 2021 May 30 ;23(6):561-573. Epub 2021 May 30. PMID: 34077834

Article Published Date : May 29, 2021

Study Type : Animal Study

Additional Links

Substances : Rosmarinic acid

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Chemotherapeutic, NF-kappaB Inhibitor, STAT3 Inhibitor

[+]

Shikonin reduced the activation and expression of STAT3, FAK and Src in vivo and reduced tumorigenicity, growth and metastasis of 4T1 cells.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Lett. 2018 09 1 ;431:123-141. Epub 2018 May 29. PMID: 29857127

Article Published Date : Dec 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Formononetin

Diseases : Multiple Myeloma, Oxidative Stress

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, STAT3 Inhibitor

[+]

These obtained results suggest that P. nigrum fruit extract has the promising strategy for immunotherapy in allergic rhinitis disease.Dec 31, 2018

Xanthohumol inhibits STAT3 activation pathway leading to growth suppression and apoptosis induction in human cholangiocarcinoma cells.Mar 31, 2016

Click here to read the entire abstract

Pubmed Data : Oncol Rep. 2016 Apr ;35(4):2065-72. Epub 2016 Jan 21. PMID: 26794001

Article Published Date : Mar 31, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Xanthohumol

Diseases : Cholangiocarcinoma

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, STAT3 Inhibitor

[+]

2-Ethoxystypandrone from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of liver cancer cells and cancer stem cells.Jan 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Prev Res (Phila). 2014 Jun ;7(6):627-38. Epub 2014 Apr 1. PMID: 24691500

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Nutr Res. 2019 ;63. Epub 2019 Aug 16. PMID: 31452653

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Chokeberry

Diseases : Atherosclerosis, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, STAT3 Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Artesunate can inhibit the proliferation of THP-1 cells.May 31, 2018

Click here to read the entire abstract

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Jun ;26(3):716-721. PMID: 29950209

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Onco Targets Ther. 2019 ;12:11437-11451. Epub 2019 Dec 24. PMID: 31920333

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Berbamine

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemosensitizer, STAT3 Inhibitor

Additional Keywords : Chemotherapeutic Synergy: Gefitinib

[+]

Berbamine synergistically enhances the antigrowth and proapoptotic effects of sorafenib on hepatocellular carcinoma cells.Sep 28, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : ACS Omega. 2020 Sep 29 ;5(38):24838-24847. Epub 2020 Sep 18. PMID: 33015502

Article Published Date : Sep 28, 2020

Study Type : In Vitro Study

Additional Links

Substances : Berbamine

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic, Chemosensitizer, STAT3 Inhibitor

Additional Keywords : Chemothapeutic Synergy: Sorafenib

[+]

[+]

Chrysanthemum indicum L. extract induces apoptosis in human prostate cancer DU145 cells.Dec 31, 2012

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2013 Jan ;27(1):30-8. Epub 2012 Mar 22. PMID: 22438130

Article Published Date : Dec 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Chrysanthemum Indicum

Diseases : Prostate Cancer

Pharmacological Actions : Apoptotic, Cell cycle arrest, STAT3 Inhibitor

Additional Keywords : Plant Extracts

[+]

Combining the Quercetin with rituximab may present an attractive and potentially effective way for the treatment of DLBCL. Oct 31, 2014

Click here to read the entire abstract

Pubmed Data : Cell Biochem Biophys. 2014 Nov ;70(2):1357-62. PMID: 24902540

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2022 Jul ;108:108894. Epub 2022 May 31. PMID: 35729830

Article Published Date : Jun 30, 2022

Study Type : In Vitro Study

Additional Links

Substances : Salvia miltiorrhiza

Diseases : Colitis, Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-6 Downregulation, STAT3 Inhibitor

[+]

Cryptotanshinone ameliorates MPP+-induced oxidative stress and apoptosis of SH-SY5Y neuroblastoma cells.May 31, 2022

Click here to read the entire abstract

Pubmed Data : Metab Brain Dis. 2022 Jun ;37(5):1477-1485. Epub 2022 Apr 9. PMID: 35396628

Article Published Date : May 31, 2022

Study Type : In Vitro Study

Additional Links

Substances : Salvia miltiorrhiza

Diseases : Oxidative Stress, Parkinson's Disease

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents, STAT3 Inhibitor

[+]

Cryptotanshinone enhances the efficacy of Bcr-Abl tyrosine kinase inhibitors via inhibiting STAT3 and eIF4E signalling pathways in chronic myeloid leukaemia.Nov 30, 2021

Curcumin significantly decreased glioblastoma stem cells proliferation, sphere forming ability and colony forming potential.Feb 03, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Cancer. 2017 Feb 4 ;17(1):99. Epub 2017 Feb 4. PMID: 28160777

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Anticancer Res. 2022 Aug ;42(8):3825-3833. PMID: 35896265

Article Published Date : Jul 31, 2022

Study Type : In Vitro Study

Additional Links

Substances : Magnolol

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Anti-metastatic, Apoptotic, NF-kappaB Inhibitor, STAT3 Inhibitor

[+]

Magnolol inhibits cancer stemness and IL-6/Stat3 signaling in oral carcinomas.Feb 03, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Formos Med Assoc. 2021 Feb 4. Epub 2021 Feb 4. PMID: 33551310

Article Published Date : Feb 03, 2021

Study Type : In Vitro Study

Additional Links

Substances : Magnolol

Diseases : Oral Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Chemosensitizer, Interleukin-6 Downregulation, STAT3 Inhibitor

Additional Keywords : Cancer Stem Cells, Chemotherapeutic Synergy: Cisplatin

[+]

Modified citrus pectin targets galectin-3-induced STAT3 activation and synergize paclitaxel cytotoxic effect on ovarian cancer spheroids.Jul 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int Immunopharmacol. 2021 Feb ;91:107279. Epub 2020 Dec 16. PMID: 33340783

Article Published Date : Jan 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids

Diseases : Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, Renoprotective, STAT3 Inhibitor, Transforming growth factor beta (TGF-β) inhibitor

[+]

Nexrutine a bark extract from Phellodendron amurense exhibits excellent anticancer activity in human pancreatic cancer cells.May 14, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2015 Jun 16 ;15:185. Epub 2015 Jun 16. PMID: 26077338

Article Published Date : Jun 15, 2015

Study Type : In Vitro Study

Additional Links

Substances : Lychee

Diseases : Fatty Liver, Insulin Resistance

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, STAT3 Inhibitor

[+]

Oridonin alleviates IRI-induced kidney injury by inhibiting inflammatory response of macrophages.May 03, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2019 Mar 25 ;232:62-72. Epub 2018 Dec 13. PMID: 30553869

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2020 Jan 5 ;315:108874. Epub 2019 Oct 24. PMID: 31669322

Article Published Date : Jan 04, 2020

Study Type : In Vitro Study

Additional Links

Substances : Saikosaponin

Diseases : Allergic Rhinitis, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, STAT3 Inhibitor

[+]

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2019 Jul 31 ;65(6):96-100. Epub 2019 Jul 31. PMID: 31472054

Article Published Date : Jul 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Sesame Seeds

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Interleukin-6 Downregulation, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, STAT3 Inhibitor

[+]

[+]

Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells.Sep 30, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2022 May 16 ;23(10). Epub 2022 May 16. PMID: 35628363

Article Published Date : May 15, 2022

Study Type : In Vitro Study

Additional Links

Substances : Beta-Elemene

Diseases : Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, Renoprotective, STAT3 Inhibitor

[+]

β-elemene triggers ROS-dependent apoptosis in glioblastoma cells.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pathol Oncol Res. 2021 ;27:594299. Epub 2021 Mar 25. PMID: 34257541

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Beta-Elemene

Diseases : Glioblastoma

Pharmacological Actions : Apoptotic, STAT3 Inhibitor

STAT3 Inhibitor jQuery(function ($) { $(".node-field-image").click(function () { $(".node-field-image").toggleClass("open"); }); $(".node.topic>.colfull").click(function () { $(".node.topic>.colfull").toggleClass("open"); }); })

Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 215 Abstracts with STAT3 Inhibitor Research

Limited to Members Only

Currently Available Sorting Options

Clinical management of COVID-19 in cancer patients with the STAT3 inhibitor silibinin.Dec 23, 2021

Cucurbitacin B significantly reduced the frequency of immature myeloid cells in patients with lung cancers.Sep 30, 2012

Potential value and mechanism of Rosa roxburghii tratt juice on pro-inflammatory responses in peripheral blood of patients with arsenic poisoning.Dec 31, 2021

Cryptotanshinone attenuated pathological cardiac remodeling. Dec 31, 2022

Ginsenoside Rh1 protects human endothelial cells against lipopolysaccharide-induced inflammatory injury.Nov 14, 2022

Omega-3 polyunsaturated fatty acids provoke apoptosis in hepatocellular carcinoma.May 08, 2022

Terminalia chebula extract ameliorates the symptoms of atopic dermatitis.Jul 03, 2022

3, 3'- diindolylmethane hinders IL-17A/IL-17RA interaction and mitigates imiquimod-induced psoriasis.Jul 31, 2022

An herbal formula inhibits STAT3 signalling and attenuates bone erosion in collagen-induced arthritis.May 29, 2020

Antrodia camphorata mycelia exert anti-liver cancer effects.Dec 31, 2017

Apigenin inhibits STAT3/CD36 signaling axis and reduces visceral obesity.Dec 22, 2019

Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancerJan 02, 2017

Arctiin inhibits inflammation, fibrosis, and tumor cell migration in rats with Ehrlich solid carcinoma.Aug 31, 2023

Astaxanthin protects against ethanol-induced liver injury.Sep 19, 2018

Avocado may be used as a promising therapeutic against inflammatory bowel diseases.Jan 04, 2019

Chrysoeriol ameliorates TPA-induced acute skin inflammation.Feb 29, 2020

Cocoa may be a potential agent in the prevention and treatment of colitis-associated cancer.Aug 09, 2015

Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity.Feb 19, 2020

Cucurbitacin E ameliorates acute graft-versus-host disease.Sep 17, 2018

Cucurbitacin-B attenuates carbon tetrachloride induced hepatic fibrosis in mice through inhibition of STAT-3.Dec 16, 2017

Dandelion polysaccharide can decrease the level of IL-6 in rats with ulcerative colitis.May 07, 2017

Diosmin functions as a potent inhibitor of tumor development and progression.Sep 30, 2016

EGCG decreased the arthritis index and showed protective effects against joint destruction in collagen-induced arthritis mice.Mar 07, 2016

Electroacupuncture pre-treatment alleviates sepsis-induced cardiac inflammation and dysfunction.Dec 31, 2021

Fingolimod in combination with berberine at reduced doses represents a novel therapy for ulcerative colitis.May 19, 2020

Genistein may be a promising alternative adjuvant therapy for patients with esophageal carcinoma.Apr 09, 2020

Ginsenoside compound K might be a potential therapeutic candidate for human liver cancer.Jun 18, 2018

Ginsenoside Rd ameliorates muscle wasting.Sep 19, 2022

Ginsenoside Rg1 attenuates lung injury in mice with type 2 diabetes mellitus-associated pulmonary tuberculosis.Dec 31, 2021

Ginsenoside Rg3 in combination with artesunate overcomes sorafenib resistance in hepatoma cell and mouse models.Apr 30, 2022

Gynostemma pentaphyllum saponins attenuate inflammation in vitro and in vivo by inhibition of NF-κB and STAT3 signaling.Oct 19, 2017

Hemp seed and evening primrose oils treatment can be used to ameliorate the demyelination of spinal cord.Mar 31, 2019

High-dose magnesium isoglycyrrhizinate can extend survival time in rats after excessive hepatectomy.Nov 20, 2015

Hirsutanol A could be a useful agent for treating inflammatory diseases.Jun 16, 2019

Honokiol could provide novel chemopreventive or therapeutic options for preventing both lung tumor progression and lung cancer metastasis.Jan 31, 2017

Honokiol protects against renal renal ischemia/reperfusion injury in rats. Jan 31, 2016

Honokiol-chlorambucil co-prodrugs selectively enhance the killing effect through STAT3 binding on lymphocytic leukemia cells.Aug 10, 2020

Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma.Dec 31, 2015

Inhibitory effect of carnosol on phthalic anhydride-induced atopic dermatitis via inhibition of STAT3.Aug 31, 2017

Intragastric administration of curcumin inhibited the experimentally induced murine colitis.Feb 28, 2018

Luteolin attenuates diabetic nephropathy through suppressing inflammatory response and oxidative stress.Jan 01, 2020

Luteolin restricts African swine fever replication by regulating the NF-κB/STAT3/ATF6 signaling pathway.Aug 03, 2022

Magnolol as STAT3 inhibitor for treating multiple sclerosis by restricting Th17 cells.Jul 31, 2023

Oleanolic acid inhibits colorectal cancer angiogenesis in vivo and in vitro.May 31, 2016

Paeoniflorin alleviates the progression of retinal vein occlusion.Apr 30, 2022

Paeoniflorin inhibits the growth of bladder carcinoma via deactivation of STAT3.May 31, 2018

Paeonol inhibits B16F10 melanoma metastasis in vitro and in vivo.Sep 30, 2015

Panax notoginseng saponins alleviates inflammation induced by microglial activation and protects against ischemic brain injury.Oct 31, 2022

Perilla frutescens extracts protects against dextran sulfate sodium-induced murine colitis.Dec 31, 2016

Phloretin may be a potent reagent for hepatocellular carcinoma treatment. Oct 15, 2019

Piperlongumine could be used to overcome bortezomib resistance in multiple myeloma.Nov 07, 2016

Piperlongumine was a direct STAT3 inhibitor and caused regression of breast cancer cell line xenografts in nude mice.Mar 30, 2014

Pterostilbene alleviates renal fibrosis in a severe mouse model of hyperuricemic nephropathy.Dec 31, 2018

Puerarin can reduce the oxidative stress damage of the retina.Nov 30, 2017

Quercetin prevents alcohol-induced liver injury.Nov 30, 2017

Resveratrol and piceatannol inhibit inflammation in a mouse model of colitis. Jan 01, 2009

Rosmarinic acid has an ameliorative effect on colonic inflammation and thus a potential therapeutic role in colitis.Apr 05, 2017

Rosmarinic acid represses colitis-associated colon cancer.May 29, 2021

Shikonin reduced the activation and expression of STAT3, FAK and Src in vivo and reduced tumorigenicity, growth and metastasis of 4T1 cells.Dec 31, 2014

The combination of Astragalus membranaceus and Angelica sinensis inhibits lung cancer and cachexia through its immunomodulatory function.Dec 31, 2018

The concomitant reduction in COX-2 expression in paw tissues suggested kaempferol's role in mitigation of inflammation by targeting STAT3 and NF-κB.Nov 30, 2017

The current study clearly indicates that 6-shogaol can be exploited for the prevention and treatment of NSCLC.Feb 28, 2014

These culture and preclinical studies indicate that the activity of the Stat3 pathway can be suppressed by curcumin treatment.Aug 31, 2012

These findings indicate that formononetin exhibits significant anti-cancer effects in multiple myeloma.Dec 31, 2017

These obtained results suggest that P. nigrum fruit extract has the promising strategy for immunotherapy in allergic rhinitis disease.Dec 31, 2018

These results indicated that beta-elemene promoted the anti-proliferative and apoptotic effect of cisplatin.Mar 28, 2017

These results support the use of CoQ10 as a potential targeted therapy for the treatment of colitis.Aug 31, 2017

This present research explores Maca as an effective hepatoprotective medicine to inhibit inflammation and liver injury caused by acute hepatitis.Dec 31, 2017

This study indicates that quercetin may improve hepatic fibrosis.Sep 30, 2019

This study provides better understanding of the beneficial effects of Lycopene against insulin resistance and metabolic disorder.May 03, 2017

Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3.Aug 17, 2019

Thymoquinone was significantly effective as an antitumor agent in a xenograft tumor mouse model.Apr 27, 2016

STAT3 Inhibitor

View the Evidence:
215 Abstracts with STAT3 Inhibitor Research

Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3.Aug 17, 2019