Telomerase Inhibitor

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48 Substances Researched for Telomerase Inhibitor
NameACCKFocus
DHA (Docosahexaenoic Acid)110Locked
Fish Oil110Locked
Thymoquinone37Locked
Curcumin66Locked
EGCG (Epigallocatechin gallate)44Locked
Sulforaphane33Locked
Blackberry22Locked
Chinese Skullcap 22Locked
Crocin22Locked
Ginsenosides22Locked
Helenalin22Locked
Indole-3-Carbinol22Locked
Pterostilbene22Locked
Silymarin22Locked
Allicin11Locked
Andrographis11Locked
Bee Propolis11Locked
Berberine11Locked
Beta-Elemene11Locked
Bufalin11Locked
Catechols11Locked
Cinnamon11Locked
Cucurbitacin B 11Locked
Diosgenin11Locked
Emodin11Locked
Fenugreek11Locked
Flavonoids11Locked
Fucoidan11Locked
Ginger11Locked
Ginseng (Korean)11Locked
Homeopathic Medicine: All11Locked
Lichens11Locked
Luteolin11Locked
Melatonin11Locked
Milk Thistle11Locked
Mushrooms: All 11Locked
Myricetin11Locked
Phyllanthus urinaria11Locked
Psychedelics:All 11Locked
Red Sage11Locked
Reishi Mushroom11Locked
Rose 11Locked
Spirulina11Locked
Tabebuia11Locked
Traditional Chinese Medicine: Xiaotan sanjie recipe11Locked
Trichosanthes Kirilowii 11Locked
Walnut11Locked
Wogonin11Locked

View the Evidence:
65 Abstracts with Telomerase Inhibitor Research

[+]

Childhood trauma is associated with accelerated aging (shortened telomere length) in post-traumatic stress disorder.Apr 12, 2011

Pubmed Data : Biol Psychiatry. 2011 Apr 12. Epub 2011 Apr 12. PMID: 21489410
Article Published Date : Apr 12, 2011
Study Type : Human Study
Additional Links
Diseases : Aging, Childhood Trauma, Post-Traumatic Stress Disorders (PTSD)
Pharmacological Actions : Telomerase Inhibitor
Additional Keywords : Psychobiology
Anti Therapeutic Actions : Childhood Trauma
[+]

Serum oxidized low-density lipoprotein is inversely correlated to telomerase activity in peripheral blood mononuclear cells of haemodialysis patients..Dec 01, 2006

Pubmed Data : Nephrology (Carlton). 2006 Dec;11(6):506-9. PMID: 17199788
Article Published Date : Dec 01, 2006
Study Type : Human Study
Additional Links
Diseases : Aging, Atherosclerosis, Cholesterol: Oxidation, Hemodialysis, Kidney Failure: Chronic, Oxidative Stress
Pharmacological Actions : Interleukin-10 downregulation, Telomerase Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Short-time DHA-enriched fish oil supplementation caused increased levels of P16 expression and a decline in telomerase activity.Dec 18, 2016

Pubmed Data : Clin Nutr. 2016 Dec 19. Epub 2016 Dec 19. PMID: 28024882
Article Published Date : Dec 18, 2016
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid), Fish Oil
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : P16 Activation, Telomerase Inhibitor
[+]

Thymoquinone could be useful as a potential chemotherapeutic agent in the management for brain tumours.Aug 11, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2010 Aug 12 ;5(8):e12124. Epub 2010 Aug 12. PMID: 20711342
Article Published Date : Aug 11, 2010
Study Type : Human In Vitro
Additional Links
Substances : Thymoquinone
Diseases : Glioblastoma
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemotherapeutic, Telomerase Inhibitor
[+]

Telomerase activity and cellular aging might be positively modified by a yoga-based lifestyle intervention.May 31, 2015

Pubmed Data : J Altern Complement Med. 2015 Jun ;21(6):370-2. Epub 2015 May 12. PMID: 25964984
Article Published Date : May 31, 2015
Study Type : Human: Case Report
Additional Links
Diseases : Aging, Oxidative Stress
Therapeutic Actions : Yoga
Pharmacological Actions : Antioxidants, Telomerase Inhibitor
[+]

A compound within Red Sage (tanshinone) induces programmed cell death in monocyte leukemia cells.Jan 01, 2010

Pubmed Data : Int J Mol Sci. 2010;11(6):2267-80. Epub 2010 May 26. PMID: 20640151
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Leukemia
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Telomerase Inhibitor
[+]

A comprehensive review on anticancer mechanisms of crocin.Jul 02, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharm Pharmacol. 2017 Jul 3. Epub 2017 Jul 3. PMID: 28675431
Article Published Date : Jul 02, 2017
Study Type : Review
Additional Links
Substances : Crocin
Diseases : Cancers: All
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Chemotherapeutic, Telomerase Inhibitor
Additional Keywords : Anti-metastatic, Antiproliferative, Apoptotic, Cancers: All, Chemotherapeutic, Crocin, Telomerase Inhibitor
[+]

A water extract of U. esculenta has a great potential to be developed into an anticancer agent that targets telomerase. Dec 31, 2013

Pubmed Data : Int J Med Mushrooms. 2014 ;16(1):17-28. PMID: 24940901
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Lichens, Mushrooms: All
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Telomerase Inhibitor
Additional Keywords : Plant Extracts
[+]

Allicin can inhibit telomerase activity and induce apoptosis of gastric cancer SGC-7901 cells. Aug 31, 2003

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2003 Sep ;9(9):1930-4. PMID: 12970878
Article Published Date : Aug 31, 2003
Study Type : In Vitro Study
Additional Links
Substances : Allicin
Diseases : Gastric Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Telomerase Inhibitor
Additional Keywords : Natural Substances Versus Drugs
[+]

Aloe emodin inhibits telomerase activity in breast cancer cells: transcriptional and enzymological mechanism.Mar 22, 2020

Pubmed Data : Pharmacol Rep. 2020 Mar 23. Epub 2020 Mar 23. PMID: 32207090
Article Published Date : Mar 22, 2020
Study Type : In Vitro Study
Additional Links
Substances : Emodin
Diseases : Breast Cancer
Pharmacological Actions : Telomerase Inhibitor
[+]

Andrographis paniculata extract as an immunity modulator against cancer via telomerase inhibition.Oct 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : 3 Biotech. 2022 Nov ;12(11):319. Epub 2022 Oct 10. PMID: 36245958
Article Published Date : Oct 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Andrographis
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Telomerase Inhibitor
[+]

Anti-proliferative and anti-telomerase effects of blackberry juice and berry-derived polyphenols on HepG2 liver cancer cells.Mar 13, 2021

Pubmed Data : Anticancer Agents Med Chem. 2021 Mar 14. Epub 2021 Mar 14. PMID: 33719965
Article Published Date : Mar 13, 2021
Study Type : In Vitro Study
Additional Links
Substances : Blackberry
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Telomerase Inhibitor
[+]

Anti-tumor activity of the ginsenoside Rk1 in human hepatocellular carcinoma cells through inhibition of telomerase activity and induction of apoptosis.Apr 30, 2008

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2008 May ;31(5):826-30. PMID: 18451501
Article Published Date : Apr 30, 2008
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Telomerase Inhibitor
[+]

Blackberry extract Inhibits telomerase activity in human colorectal cancer cells.Dec 31, 2018

Pubmed Data : Nutr Cancer. 2019 ;71(3):461-471. Epub 2018 Oct 29. PMID: 30372130
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Blackberry
Diseases : Colorectal Cancer
Pharmacological Actions : Telomerase Inhibitor
[+]

Bufalin inhibited the proliferation and migration of and induced apoptosis in LoVo and SW620 cells.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2016 ;40(6):1559-1569. Epub 2016 Dec 21. PMID: 27997899
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Bufalin
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Telomerase Inhibitor
[+]

Chinese skullcap inhibits the growth of an estrogen-responsive mouse tumor cell line.May 01, 2011

Pubmed Data : Oncol Rep. 2011 May;25(5):1431-8. Epub 2011 Mar 1. PMID: 21369700
Article Published Date : May 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Chinese Skullcap
Diseases : Cancers: Estrogen Responsive, Testicular Cancer, Testicular Neoplasms
Pharmacological Actions : Apoptotic, Cell cycle arrest, Cyclin-Dependent Kinase Inhibitor , NF-kappaB Inhibitor, Telomerase Inhibitor
[+]

Crocin has therapeutic and preventive effects on cancer cell lines.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2020 Jan ;23(1):3-12. PMID: 32405344
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : Crocin
Diseases : Breast Cancer, Colorectal Cancer, Leukemia: Chronic myelogenous leukemia (CML) , Pancreatic Cancer, Prostate Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Cyclin D1 Down-Regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Telomerase Inhibitor
[+]

Cucurbitacin B exerts an anticancer effect by inhibiting telomerase in breast cancer cells.Dec 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2010 ;11(12):5323-38. Epub 2010 Dec 22. PMID: 21614210
Article Published Date : Dec 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Telomerase Inhibitor
[+]

Cuminaldehyde could be a potential agent for anticancer therapy.Apr 25, 2016

Pubmed Data : Curr Cancer Drug Targets. 2016 Apr 26. Epub 2016 Apr 26. PMID: 27113744
Article Published Date : Apr 25, 2016
Study Type : In Vitro Study
Additional Links
Substances : Cinnamon
Diseases : Carcinoma: Non-Small-Cell Lung, Colorectal Cancer, Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Telomerase Inhibitor, Topoisomerase I inhibitor, Topoisomerase II Inhibitor
Additional Keywords : Dose Response
[+]

Curcumin inhibits ionizing radiation-induced proliferation of human neuroblastoma cells.Feb 23, 2010

Pubmed Data : Gynecol Endocrinol. 2010 Feb 23. Epub 2010 Feb 23. PMID: 21236599
Article Published Date : Feb 23, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Neuroblastoma
Pharmacological Actions : Telomerase Inhibitor
[+]

Curcumin inhibits telomerase activity in breast ancer cells. Feb 01, 2011

Pubmed Data : J Urol. 2011 Feb;185(2):719-24. Epub 2010 Dec 18. PMID: 12104041
Article Published Date : Feb 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer
Pharmacological Actions : Enzyme Inhibitors, Telomerase Inhibitor
[+]

Curcumin inhibits telomerase activity in human cancer cell lines.Aug 01, 2006

Pubmed Data : Int J Mol Med. 2006 Aug;18(2):227-31. PMID: 16820928
Article Published Date : Aug 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cancers: All
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Enzyme Inhibitors, Telomerase Inhibitor
[+]

Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumour cells.Nov 27, 2012

Pubmed Data : J Cell Biochem. 2012 Nov 28. Epub 2012 Nov 28. PMID: 23192708
Article Published Date : Nov 27, 2012
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Brain Cancer
Pharmacological Actions : Telomerase Inhibitor
[+]

Curcumin inhibits telomerase expression associated with tumorigensis. Apr 01, 2010

Pubmed Data : Cancer Lett. 2010 Apr 1;290(1):76-86. Epub 2009 Sep 13. PMID: 19751963
Article Published Date : Apr 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Tumors
Pharmacological Actions : Antineoplastic Agents, Telomerase Inhibitor
[+]

Curcumin's induction of programmed cell death in human leukemia cells is associated with inhibition of telomerase activity.Mar 01, 2007

Pubmed Data : Mol Cell Biochem. 2007 Mar;297(1-2):31-9. Epub 2006 Nov 10. PMID: 17096185
Article Published Date : Mar 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia, Promyelocytic leukemia
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Telomerase Inhibitor
[+]

Cytotoxic effect of Rosa canina extract on human colon cancer cells through repression of telomerase expression.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharm Anal. 2018 Dec ;8(6):394-399. Epub 2017 Dec 15. PMID: 30595946
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Rose
Diseases : Colon Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Telomerase Inhibitor
[+]

Diosgenin inhibits telomerase activity by down regulation of hTERT gene expression in A549 cell line.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2013 ;14(11):6945-8. PMID: 24377630
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Diosgenin, Fenugreek
Diseases : Lung Cancer
Pharmacological Actions : Antioxidant, Antiproliferative , Chemopreventive, Telomerase Inhibitor
Additional Keywords : Gene Expression Regulation
[+]

Dual effect of Sapogenins extracted from Spirulina platensis on telomerase activity in two different cell lines.Feb 28, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Biol Res Commun. 2021 Mar ;10(1):1-4. PMID: 33681391
Article Published Date : Feb 28, 2021
Study Type : In Vitro Study
Additional Links
Substances : Spirulina
Diseases : Aging, Breast Cancer, Skin Cancer
Pharmacological Actions : Telomerase Inhibitor, Telomerase Upregulation
[+]

EGCG fights cancer by modulating telomerase activity.Nov 01, 1999

Pubmed Data : J Ethnopharmacol. 1999 Nov 1;67(2):233-9. PMID: 17570133
Article Published Date : Nov 01, 1999
Study Type : Commentary
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Cancers: All
Pharmacological Actions : Telomerase Inhibitor
Additional Keywords : Epigenetic Modification
[+]

Epigallocatechin-3-gallate (EGCG) induces telomere shortening and clastogenic damage in glioblastoma cells.Apr 25, 2019

Pubmed Data : Environ Mol Mutagen. 2019 Apr 26. Epub 2019 Apr 26. PMID: 31026358
Article Published Date : Apr 25, 2019
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Glioblastoma
Pharmacological Actions : Telomerase Inhibitor
[+]

Fucoidan could induce apoptosis and the inhibition of telomerase activity in bladder cancer cells. Sep 20, 2016

Pubmed Data : Drug Dev Res. 2016 Sep 21. Epub 2016 Sep 21. PMID: 27654302
Article Published Date : Sep 20, 2016
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Bladder Cancer
Pharmacological Actions : Apoptotic, Telomerase Inhibitor
[+]

Ginger exhibits anti-lung cancer properties.Dec 01, 2010

Pubmed Data : J Med Food. 2010 Dec;13(6):1347-54. PMID: 21091248
Article Published Date : Dec 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Catechols, Ginger
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Telomerase Inhibitor
Additional Keywords : Plant Extracts
[+]

Green Tea induces apoptosis in drug-resistant small-cell lung carcinoma.Aug 17, 2007

Pubmed Data : Biochem Biophys Res Commun. 2007 Aug 17;360(1):233-7. Epub 2007 Jun 14. PMID: 17585882
Article Published Date : Aug 17, 2007
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Carcinoma: Small Cell Lung, Lung Cancer
Pharmacological Actions : Apoptotic, Telomerase Inhibitor
Additional Keywords : Drug Resistant Cancer
[+]

Harmine inhibits telomerase activity of MCF-7 cellsDec 31, 2012

Pubmed Data : PeerJ. 2013 ;1:e174. Epub 2013 Oct 1. PMID: 24109558
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Psychedelics:All
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Telomerase Inhibitor
[+]

Hep C 30 has demonstrable anticancer effects against liver cancer cells in vitro.Apr 30, 2016

Pubmed Data : J Integr Med. 2016 May ;14(3):209-18. PMID: 27181128
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Homeopathic Medicine: All
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation, Telomerase Inhibitor
[+]

Indole-3-carbinol induces apoptosis of chronic myelogenous leukemia cells.May 31, 2017

Pubmed Data : Tumour Biol. 2017 Jun ;39(6):1010428317705768. PMID: 28631564
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Indole-3-Carbinol
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Telomerase Inhibitor
[+]

Indole-3-carbinol inhibits telomerase activity and gene expression in prostate cancer cell lines.Oct 31, 2011

Pubmed Data : Anticancer Res. 2011 Nov ;31(11):3733-7. PMID: 22110194
Article Published Date : Oct 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Indole-3-Carbinol
Diseases : Prostate Cancer
Pharmacological Actions : MicroRNA modulator, Telomerase Inhibitor
[+]

Manisa propolis inhibits a T-cell acute lymphoblastic leukemia cell line. Nov 01, 2005

Pubmed Data : Leuk Res. 2005 Nov;29(11):1343-6. PMID: 16055186
Article Published Date : Nov 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Bee Propolis
Diseases : Acute T cell Leukemias, Leukemia: T-cell acute Lymphoblastic
Pharmacological Actions : Telomerase Inhibitor
[+]

Melatonin not only inhibits breast cancer cell growth, but also is capable of inhibiting angiogenesis, cancer cell invasion, and telomerase activity.Mar 25, 2016

Pubmed Data : Breast Cancer. 2016 Mar 26. Epub 2016 Mar 26. PMID: 27017208
Article Published Date : Mar 25, 2016
Study Type : Review
Additional Links
Substances : Melatonin
Diseases : Breast Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative , Telomerase Inhibitor
[+]

Myricetin arrests human telomeric G-quadruplex structure: a new mechanistic approach as an anticancer agent.Jan 18, 2016

Pubmed Data : Mol Biosyst. 2016 07 19 ;12(8):2506-18. PMID: 27249025
Article Published Date : Jan 18, 2016
Study Type : In Vitro Study
Additional Links
Substances : Myricetin
Diseases : Cancers: All
Pharmacological Actions : Chemotherapeutic, Telomerase Inhibitor
[+]

Nano encapsulated helenalin could be used for inhibiting the growth of breast cancer cells.Dec 31, 2015

Pubmed Data : Artif Cells Nanomed Biotechnol. 2016 ;44(2):695-703. Epub 2014 Dec 1. PMID: 25435410
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Helenalin
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Telomerase Inhibitor
[+]

Phyllanthus urinaria induces programmed cell death and reduces telomerase activity in nasopharyngeal cancer cells.Feb 01, 2009

Pubmed Data : Forsch Komplementmed. 2009 Feb;16(1):34-40. Epub 2009 Feb 6. PMID: 19295228
Article Published Date : Feb 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Phyllanthus urinaria
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Apoptotic, Telomerase Inhibitor
[+]

Prostate cancer involves shortened chromosomal telomeres and excessive telomerase activity. Telomerase inhibitors may have a therapeutic role to play in prostate cancer treatment. Mar 01, 2006

Pubmed Data : Urol Oncol. 2006 Mar-Apr;24(2):122-30. PMID: 16520276
Article Published Date : Mar 01, 2006
Study Type : Review
Additional Links
Diseases : Prostate Cancer
Pharmacological Actions : Telomerase Inhibitor
[+]

Pterostilbene exhibited significant telomerase inhibition in breast and lung cancer cells.Dec 31, 2013

Pubmed Data : Curr Pharm Biotechnol. 2014 ;14(12):1027-35. PMID: 24433502
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Pterostilbene
Diseases : Breast Cancer, Lung Cancer
Pharmacological Actions : Antiproliferative , Telomerase Inhibitor
[+]

Reishi mushroom modulated the miRNA expression in the pathways that regulate telomerase activity in MCF-7 breast cancer cellsDec 31, 2014

Pubmed Data : Int J Med Mushrooms. 2015 ;17(3):231-9. PMID: 25954907
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Reishi Mushroom
Diseases : Breast Cancer
Pharmacological Actions : MicroRNA modulator, Telomerase Inhibitor
[+]

Silymarin was found to be able to inhibit telomerase activity in HepG2 cells.Feb 28, 2015

Pubmed Data : J BUON. 2015 Mar-Apr;20(2):555-61. PMID: 26011349
Article Published Date : Feb 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Milk Thistle, Silymarin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Telomerase Inhibitor
Additional Keywords : Plant Extracts
[+]

Sulforaphane may regress cancerous epigenetic patterns in human bresat cancer cells.Jan 01, 2010

Pubmed Data : Curr Pharm Des. 2010;16(7):884-92. PMID: 20625516
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer
Pharmacological Actions : Telomerase Inhibitor
Additional Keywords : Epigenetic Modification
[+]

Sulforaphane with EGCG can inhibit both paclitaxel-sensitive and resistant ovarian cancer cells.Mar 09, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Cell Res. 2013 Mar 10 ;319(5):697-706. Epub 2013 Jan 16. PMID: 23333498
Article Published Date : Mar 09, 2013
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Sulforaphane
Diseases : Cancers: Drug Resistant, Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Telomerase Inhibitor
Additional Keywords : Isothiocyanates
[+]

Tabebuia tree bark contains beta-lapachone which inhibits prostate cancer cells via downregulation of cox-2 enzyme, PGE2 and telomerase activity.Jun 01, 2005

Pubmed Data : Pharmacol Res. 2005 Jun;51(6):553-60. PMID: 15829436
Article Published Date : Jun 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Tabebuia
Diseases : Prostate Cancer
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Prostaglandin Antagonists, Telomerase Inhibitor
[+]

Telomerase activity and its association with psychological stress, mental disorders, lifestyle factors and interventions.Jan 31, 2016

Pubmed Data : Psychoneuroendocrinology. 2016 Feb ;64:150-63. Epub 2015 Nov 25. PMID: 26677763
Article Published Date : Jan 31, 2016
Study Type : Review
Additional Links
Diseases : Depression
Therapeutic Actions : Exercise, Meditation , Yoga
Pharmacological Actions : Telomerase Inhibitor, Telomerase Upregulation
[+]

Telomerase inhibitors TMPyP4 and thymoquinone decreased cell proliferation and induced cell death in the non-small cell lung cancer cell line LC-HK2.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Braz J Med Biol Res. 2023 ;56:e12897. Epub 2023 Oct 27. PMID: 37909496
Article Published Date : Dec 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Enzyme Inhibitors, Telomerase Inhibitor
[+]

Telomere lengths remain long (near that of infancy) in the human heart, brain, eyes (retina), testes, and ovaries. Acupuncture and acupressure reduce telomerase activity in tumors and increase telomerase in normal tissue. Jun 01, 1991

Pubmed Data : Chem Pharm Bull (Tokyo). 1991 Jun;39(6):1606-8. PMID: 10193703
Article Published Date : Jun 01, 1991
Study Type : Review
Additional Links
Diseases : Aging
Therapeutic Actions : Acupressure, Acupuncture
Pharmacological Actions : Telomerase Inhibitor, Telomerase Upregulation
[+]

The inhibitory effect of helenalin on telomerase activity is attributed to the alkylation of the CYS445 residue.May 31, 2014

Pubmed Data : J Mol Graph Model. 2014 Jun ;51:97-103. Epub 2014 May 6. PMID: 24863344
Article Published Date : May 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Helenalin
Diseases : Cancers: All
Pharmacological Actions : Enzyme Inhibitors, Telomerase Inhibitor
[+]

The review also summarizes the current knowledge on the effect of ginsenosides in the treatment of cancer.Jun 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ginseng Res. 2018 Jul ;42(3):248-254. Epub 2017 May 15. PMID: 29983605
Article Published Date : Jun 30, 2018
Study Type : Review
Additional Links
Substances : Ginseng (Korean), Ginsenosides
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Antioxidants, Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Telomerase Inhibitor
[+]

The role of natural flavonoids as telomerase inhibitors in suppressing cancer growth.Apr 16, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2023 Apr 17 ;16(4). Epub 2023 Apr 17. PMID: 37111362
Article Published Date : Apr 16, 2023
Study Type : Review
Additional Links
Substances : Flavonoids, Luteolin
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative , Telomerase Inhibitor
[+]

The treatment of the K562 cells with silymarin resulted in a significant inhibition of cell growth and telomerase activity.May 31, 2012

Pubmed Data : Planta Med. 2012 Jun ;78(9):899-902. Epub 2012 Apr 24. PMID: 22532022
Article Published Date : May 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Silymarin
Diseases : Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Telomerase Inhibitor
[+]

These combined results strongly support a role for sulforaphane in the mediation of epigenetic events leading to the repression of hTERT in prostate cancer cells.Sep 08, 2015

Pubmed Data : Biochem Cell Biol. 2015 Sep 9:1-11. Epub 2015 Sep 9. PMID: 26458818
Article Published Date : Sep 08, 2015
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Prostate Cancer
Pharmacological Actions : Chemopreventive, Telomerase Inhibitor
Additional Keywords : Epigenetic Modification
[+]

These findings provide new insights into understanding the anticancer mechanisms of berberine in human lung cancer therapy.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(7):e69240. Epub 2013 Jul 15. PMID: 23869238
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, NF-kappaB Inhibitor, Telomerase Inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

This study explores the novel anticancer mechanism of Pterostilbene’s senescence induction via the inhibition of telomerase in lung cancer cells.Aug 09, 2017

Pubmed Data : Cell Death Dis. 2017 Aug 10 ;8(8):e2985. Epub 2017 Aug 10. PMID: 28796247
Article Published Date : Aug 09, 2017
Study Type : In Vitro Study
Additional Links
Substances : Pterostilbene
Diseases : Lung Cancer
Pharmacological Actions : Chemotherapeutic, Telomerase Inhibitor
[+]

Thymoquinone suppresses growth and invasion and induces apoptosis of glial tumor cells.Jul 22, 2016

Pubmed Data : Biomed Pharmacother. 2016 Jul 23 ;83:635-640. Epub 2016 Jul 23. PMID: 27459120
Article Published Date : Jul 22, 2016
Study Type : Review
Additional Links
Substances : Thymoquinone
Diseases : Glial Cell Tumors, Glioblastoma, Neurodegenerative Diseases
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Autophagy Inhibitors, Telomerase Inhibitor
Additional Keywords : Blood Brain Barrier
[+]

Trichosanthes kirilowii extract has antitumor activity in lung cancer cells.Nov 01, 2010

Pubmed Data : Pharm Biol. 2010 Nov;48(11):1302-9. Epub 2010 Aug 25. PMID: 20738166
Article Published Date : Nov 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Trichosanthes Kirilowii
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Telomerase Inhibitor
Additional Keywords : Plant Extracts
[+]

Walnut phenolic extracts reduce telomere length and telomerase activity in a colon cancer stem cell model.Jan 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Res Pract. 2019 Feb ;13(1):58-63. Epub 2018 Dec 3. PMID: 30788057
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Walnut
Diseases : Colon Cancer
Pharmacological Actions : Telomerase Inhibitor
Additional Keywords : Cancer Stem Cells
[+]

Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the promyelocytic leukemia cells.Jan 01, 2010

Pubmed Data : Phytomedicine. 2010 Jan;17(1):47-54. Epub 2009 Jul 3. PMID: 19577445
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Chinese Skullcap , Wogonin
Diseases : Promyelocytic leukemia
Pharmacological Actions : Apoptotic, Telomerase Inhibitor
[+]

Xiaotan sanjie recipe inhibits the proliferation of gastric cancer cells.Dec 01, 2010

Pubmed Data : J Tradit Chin Med. 2010 Dec;30(4):249-53. PMID: 21287780
Article Published Date : Dec 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Traditional Chinese Medicine: Xiaotan sanjie recipe
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Telomerase Inhibitor
[+]

β-Elemene inhibits the proliferation of esophageal squamous cell carcinoma by regulating long noncoding RNA-mediated inhibition of hTERT expression.May 31, 2015

Pubmed Data : Anticancer Drugs. 2015 Jun ;26(5):531-9. PMID: 25646744
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Beta-Elemene
Diseases : Esophageal Cancer, Squamous cell carcinoma
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Telomerase Inhibitor

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