Toggle navigation
Research Tools
Research Dashboard
Search Abstracts
Search Articles
Search All Content (Google)
Topic Research Discovery
Diseases
Therapeutic Substances
Therapeutic Actions
Pharmacological Actions
Problem Substances
Problematic Actions
Adverse Pharmacological Actions
Trending Topics
Smart Search - Evidence Generator
Smart Search: Diseases
Smart Search: Therapeutic Substances
Smart Search: Pharmacological Actions
Articles
Most Recent
Most Popular
Find Articles
My Membership
Memberships
Compare Membership Plans
Join our Free Newsletter
Log in
or
Join us
x
This is a member's only feature.
Please
join or upgrade
x
This is a member's only feature.
Please
join or upgrade
Tumor Suppressor Protein p53 Upregulation
Views 2635
Jump to
Abstracts
Focused Research Topics
Focus Your Research
Click any topic below to filter + focus research
229 Substances Researched for Tumor Suppressor Protein p53 Upregulation
Name
AC
CK
Focus
Curcumin
46
56
Resveratrol
24
28
Flavonoids
14
18
Melatonin
15
18
Citral
3
16
Ginsenosides
12
14
Thymoquinone
7
12
Cryptoxanthin
2
11
Verbena officinalis
1
10
Apigenin
3
9
EGCG (Epigallocatechin gallate)
6
9
Sulforaphane
5
9
Berberine
7
8
Homeopathic Medicine: All
6
8
Quercetin
5
8
Tanshinone IIA
8
8
Vitamin C
7
8
Apple Polyphenols
3
7
Magnolol
2
7
Nigella sativa (aka Black Seed)
3
7
Turmeric
5
7
Xanthohumol
7
7
Ashwagandha
4
6
Ellagic Acid
6
6
Ginger
2
6
Isoliquiritigenin
5
6
Lysine
2
6
Naringenin
2
6
Neem
2
6
Oridonin
6
6
Phloretin
2
6
Wogonin
5
6
Isothiocyanates
3
5
Lemongrass
1
5
Luteolin
4
5
Piperine
1
5
Prickly Pear Cactus
4
5
Zerumbone
1
5
Astaxanthin
2
4
Bacopa
2
4
Catechin
3
4
Green Tea
2
4
Milk Thistle
2
4
Polyphenols
4
4
Protandim
2
4
Selenium
3
4
Shikonin
4
4
Spirulina
2
4
Betulinic acid
3
3
Chaga Mushroom (Inonotus obliquus)
3
3
Cordyceps Militaris
3
3
Deguelin
3
3
Diosmin
2
3
Fisetin
3
3
Genistein
3
3
Indole-3-Carbinol
3
3
Isoflavones
2
3
Lichens
2
3
Lignans
2
3
Myricetin
3
3
Piperlongumine
2
3
Pomegranate Peel
3
3
Pterostilbene
3
3
Rosemary
2
3
Shallot
2
3
Urolithin A
3
3
6-Shogaol
2
2
Angelica
1
2
Anthocyanins
2
2
Apple Pectin
1
2
Artemisinin
2
2
Asparagus
1
2
Benzyl isothiocyanate
1
2
Beta-Elemene
2
2
Black Pepper
1
2
Bromelain
2
2
Buckwheat
1
2
Caffeine
1
2
Capsaicin
2
2
Carnosic Acid
2
2
Carnosol
2
2
Chrysin
2
2
Cocoa
1
2
Crocetin
2
2
Crocin
2
2
Cucurbitacin B
2
2
Curcumol
1
2
D-Limonene
2
2
Damnacanthal
2
2
Diosgenin
1
2
Emodin
2
2
Feverfew
2
2
Fish Oil
1
2
Flaxseed
1
2
Fucoidan
2
2
Gac
2
2
Gallic Acid
2
2
Garlic
2
2
Gingerol
1
2
Ginkgo biloba
1
2
Ginseng (American)
1
2
Gold (nanoparticles)
2
2
Gynostemma
2
2
Honokiol
2
2
Huaier (Trametes robiniophila murr)
2
2
Huperzine
1
2
Lithospermum erythrorhizon
2
2
Long Pepper
1
2
Lupeol
1
2
Oleanolic acid
1
2
Pecan
1
2
Peony
2
2
Phenethyl isothiocyanate
1
2
Piceatannol
2
2
Polypodium leucotomos
1
2
Polyunsaturated Fatty Acids (PUFAs)
1
2
Pomegranate
1
2
Rosmarinic acid
1
2
Rutin
1
2
Salvia miltiorrhiza
1
2
Sesamin
2
2
Shemamruthaa
1
2
Silibinin
1
2
Soy Protein
1
2
Stilbenes
2
2
Tangeretin
1
2
Venom: Toad
1
2
Vitamin E
2
2
White Mulberry
2
2
Allicin
1
1
Aloe Vera
1
1
Amygdalin
1
1
Andrographis
1
1
Antineoplastons
1
1
Arnica
1
1
Asiatic Acid
1
1
Babchi
1
1
Bamboo
1
1
Barberry
1
1
Beet
1
1
Berbamine
1
1
Bergamot
1
1
Bergamot orange
1
1
Betanins
1
1
Biochanin A
1
1
Bisdemethoxycurcumin
1
1
Blueberry
1
1
Bufalin
1
1
Caffeic Acid
1
1
Chickpea
1
1
Chlorella (Algae)
1
1
Cruciferous Vegetables
1
1
Cucurbitacin E
1
1
Cyanidin 3-glucoside
1
1
DHA (Docosahexaenoic Acid)
1
1
Delphinidin
1
1
Delta-tetrahydrocannabinol (THC)
1
1
Demethoxycurcumin
1
1
Diallyl sulfide
1
1
Diosmetin
1
1
Docosahexaenoic acid (DHA)
1
1
EPA (Eicosapentaenoic Acid)
1
1
Epicatechin
1
1
False Black Pepper
1
1
Fenugreek
1
1
Gastrodin
1
1
Genipin
1
1
Ginseng
1
1
Goji
1
1
Grape
1
1
Grape Seed Extract
1
1
Guarana
1
1
Helenalin
1
1
Hibiscus
1
1
Holy Basil
1
1
Honey
1
1
Japanese mugwort
1
1
Jujube
1
1
Juniper
1
1
Kaempferol
1
1
Kahweol
1
1
Lactobacillus rhamnosus GG
1
1
Lactoferrin
1
1
Licorice
1
1
Lime: Key
1
1
Liquiritigenin
1
1
Lycopene
1
1
Maitake Mushroom
1
1
Mangiferin
1
1
Marjoram
1
1
Moringa oleifera
1
1
Mushrooms: All
1
1
Nobiletin
1
1
Oats
1
1
Oleuropein
1
1
Orange: Mandarin
1
1
Oyster Mushroom
1
1
P-Coumaric Acid
1
1
Paeoniflorin
1
1
Parthenolide
1
1
Peanut
1
1
Perilla
1
1
Phellinus Linteus
1
1
Phyllanthus amarus
1
1
Podophyllum hexandrum
1
1
Pomegranate Polyphenols
1
1
Probiotics
1
1
Propolis: Brazillian
1
1
Prunella vulgaris
1
1
Psychedelics:All
1
1
Raspberry
1
1
Reishi Mushroom
1
1
Ruta Graveolens
1
1
Schisandra
1
1
Sesame Seeds
1
1
Silver (nanoparticles)
1
1
Stevia
1
1
Tabebuia
1
1
Tannic Acid
1
1
Tea: Oolong
1
1
Tocotrienol: Gamma
1
1
Tripterygium wilfordii
1
1
Triptolide
1
1
Turmerones
1
1
Verbascoside
1
1
Vitamin D
1
1
Vitamin E: Gamma-tocotrienol
1
1
Wheat Grass
1
1
Whey
1
1
Research Articles
431
Cumulative Knowledge Score
697
Overall Research Rating
EXCELLENT
View the Evidence:
521 Abstracts with Tumor Suppressor Protein p53 Upregulation Research
Filter by Study Type
Animal Study
Human In Vitro
Human Study
In Vitro Study
Review
Transgenic Animal Study
Sort Abstracts
Limited to Members Only
By default, all articles on GreenMedInfo.com are sorted based on the content type which best reflects the data which most users are searching for. For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. This section is for allowing more advanced sorting methods. Currently, these advanced sorting methods are available for members only. If you are already a member, you can sign in by
clicking here
. If you do not currently have a user account, and would like to create one/become a member,
click here
to begin the singup process.
Currently Available Sorting Options
Article Published Date
- Sort all displayed articles by their published date
Quick Summary Fieldsets
- Sort alphabetically, rather than by Cumulative Knowledge
Cumulative Knowledge
- Default sorting method. Allows you to sort descendingly
Free Sample of Member-Only Features
Although all 30,000+ articles on GreenMedInfo.com are made entirely free to view as an educational service to the public, we provide a powerful set of enhanced data comprehension and retrieval tools for subscribing members. Above you are viewing a free preview, limited to 10000 rows, of the membership feature called "
Cumulative Knowledge
" (
learn more
).
The
Focus Article Feature
is not enabled.
Upgrading to the
Friend
membership gives you access to unlimited rows of Cumulative Knowledge data.
To Participate
Click here
to login
Click here
to order a membership
[+]
Beta-cryptoxanthin synergistically enhances the antitumoral activity of oxaliplatin.
Sep 30, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Clin Cancer Res. 2015 Oct 1 ;21(19):4398-409. Epub 2015 May 28. PMID:
26023082
Article Published Date
: Sep 30, 2015
Study Type
: Animal Study, Human Study, In Vitro Study
Additional Links
Substances
:
Cryptoxanthin
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Chemotherapeutic Synergy: Oxaliplatin
[+]
Elevated expression of the tumor suppressing protein p53 is associated with the presence of mouse mammary tumor-like env gene sequences (MMTV-like) in human breast cancer.
Aug 31, 2004
Click here to read the entire abstract
Pubmed Data
: Breast Cancer Res Treat. 2004 Sep ;87(1):13-7. PMID:
15377846
Article Published Date
: Aug 31, 2004
Study Type
: Human Study
Additional Links
Diseases
:
Breast Cancer
,
Breast Cancer: MMTV-Associated
Pharmacological Actions
:
Tumor Suppressor Protein p53 Upregulation
Problem Substances
:
Mouse Mammary Tumour Viruses (MMTV)
[+]
Stem cells and progenitors in human peripheral blood get activated by extremely active resveratrol.
Mar 31, 2018
Click here to read the entire abstract
Pubmed Data
: Stem Cell Rev Rep. 2018 Apr ;14(2):213-222. PMID:
29177909
Article Published Date
: Mar 31, 2018
Study Type
: Human Study
Additional Links
Substances
:
Resveratrol
Pharmacological Actions
:
SIRT1 Activator
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Adult Stem Cells
[+]
There is evidence that aflatoxin exposure plays a role in the pathogenesis of liver cancer in the US population.
Jan 01, 1999
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 1999 ;35(1):27-33. PMID:
10624703
Article Published Date
: Jan 01, 1999
Study Type
: Human Study
Additional Links
Diseases
:
Aflatoxicosis
,
Liver Cancer
,
Liver Damage: Aflatoxin-Induced
Pharmacological Actions
:
Tumor Suppressor Protein p53 Upregulation
Problem Substances
:
Aflatoxin
Adverse Pharmacological Actions
:
Carcinogenic
[+]
Verbena officinalis essential oil and its component citral has apoptoic-inducing activity against chronic lymphocytic leukemia.
Oct 01, 2009
Click here to read the entire abstract
Pubmed Data
: Int J Immunopathol Pharmacol. 2009 Oct-Dec;22(4):1097-104. PMID:
20074474
Article Published Date
: Oct 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Citral
,
Verbena officinalis
Diseases
:
Leukemia: Chronic Lymphocytic Leukemia (CLL)
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
A Nigella sativa extract showed a 88.3% inhibition of proliferation of SiHa human cervical cancer cells and increased the expression of caspase-3, -8 and -9 several-fold
Jan 31, 2013
Click here to read the entire abstract
Pubmed Data
: Nat Prod Commun. 2013 Feb ;8(2):213-6. PMID:
23513732
Article Published Date
: Jan 31, 2013
Study Type
: Human In Vitro
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Caspase-3 Activation
,
Caspase-8 activation
,
Caspase-9 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
Blue LED irradiation induces apoptotic cell death by activating the mitochondria-mediated pathway and reduces the early growth rate of melanoma cells.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: J Photochem Photobiol B. 2015 Jan ;142:197-203. Epub 2014 Dec 12. PMID:
25550119
Article Published Date
: Dec 31, 2014
Study Type
: Human In Vitro
Additional Links
Diseases
:
Melanoma
Therapeutic Actions
:
Light-Emitting Diodes (LEDs) Therapy
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemopreventive
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin and citral in combination may be a useful therapeutic intervention for breast cancer.
Aug 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Breast Cancer. 2015 Sep ;18(3):225-34. Epub 2015 Sep 24. PMID:
26472972
Article Published Date
: Aug 31, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Citral
,
Curcumin
,
Lemongrass
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dose Response
,
Natural Substance Synergy
,
Selective Cytotoxicity
[+]
Magnolol induced cell cycle arrest and promoted apoptosis in gallbladder carcinoma cells by regulating the p53 signaling pathway.
Sep 30, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Sci. 2015 Oct ;106(10):1341-50. PMID:
26250568
Article Published Date
: Sep 30, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Magnolol
Diseases
:
Gallbladder Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Cyclin D1 Down-Regulation
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Naringenin causes ASK1-induced apoptosis via reactive oxygen species in human pancreatic cancer cells.
Nov 08, 2016
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2016 Nov 9. Epub 2016 Aug 9. PMID:
27838343
Article Published Date
: Nov 08, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Naringenin
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Neem leaf extract exhibits anti-leukemic properties in patient primary chronic lymphocytic leukemia cells.
Feb 28, 2014
Click here to read the entire abstract
Pubmed Data
: Leuk Lymphoma. 2014 Mar ;55(3):652-61. Epub 2013 Jul 1. PMID:
23721511
Article Published Date
: Feb 28, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Neem
Diseases
:
Leukemia: Chronic Lymphocytic Leukemia (CLL)
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.
Mar 31, 2014
Click here to read the entire abstract
Pubmed Data
: Tumour Biol. 2014 Apr ;35(4):3305-10. Epub 2013 Nov 24. PMID:
24272201
Article Published Date
: Mar 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Piperine
Diseases
:
Lung Cancer
Pharmacological Actions
:
Apoptotic
,
Bax/Bcl2 ratio: Increase
,
Bcl-2 protein down-regulation
,
Caspase-3 Activation
,
Caspase-9 Activation
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Selective Cytotoxicity
[+]
The apple polyphenol phloretin inhibits colorectal cancer cell growth.
Sep 13, 2016
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2016 Sep 14 ;64(36):6826-37. Epub 2016 Sep 2. PMID:
27538679
Article Published Date
: Sep 13, 2016
Study Type
: Animal Study, Human In Vitro
Additional Links
Substances
:
Apple Polyphenols
,
Phloretin
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Tumor Suppressor Protein p53 Upregulation
[+]
The present study results indicated that human bladder cancer T-24 cells are highly sensitive to growth inhibition by apigenin.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Cell Int. 2015 ;15:33. Epub 2015 Mar 29. PMID:
25859163
Article Published Date
: Dec 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Apigenin
Diseases
:
Bladder Cancer
,
Bladder Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Cell cycle arrest
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dose Response
[+]
This study demonstrates that sulforaphane targets multiple signaling pathways to suppress ovarian cancer in vitro and in vivo.
Nov 01, 2018
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2018 Nov ;42(5):2447-2458. Epub 2018 Sep 6. PMID:
30226534
Article Published Date
: Nov 01, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
,
Female
,
Ovarian Cancer
Pharmacological Actions
:
Anti-Tumor
,
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
HER-2 oncoprotein down-regulation
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Drug Synergy
,
Isothiocyanates
[+]
Thymoquinone promotes pancreatic cancer cell death and reduction of tumor size.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Adv Prev Med. 2016 ;2016:1407840. Epub 2016 Dec 26. PMID:
28105374
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, Human In Vitro
Additional Links
Substances
:
Thymoquinone
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Cell cycle arrest
,
Histone deacetylase inhibitor
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dose Response
[+]
Zerumbone was able to induce apoptosis of pancreatic carcinoma cell lines
Jan 01, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2012 ;2012:936030. Epub 2012 Jan 29. PMID:
22454691
Article Published Date
: Jan 01, 2012
Study Type
: Human In Vitro
Additional Links
Substances
:
Ginger
,
Zerumbone
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Apoptotic
,
Caspase-3 Activation
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Zerumbone
[+]
Amentoflavone induces caspase-dependent/-independent apoptosis and dysregulates cyclin-dependent kinase-mediated cell cycle in colorectal cancer.
Apr 30, 2023
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol. 2023 May ;38(5):1078-1089. Epub 2023 Feb 2. PMID:
36727907
Article Published Date
: Apr 30, 2023
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Anticancer investigation of fullerene C60 on DMBA induced breast cancer.
Feb 14, 2022
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2022 Feb 15 ;291:120281. Epub 2022 Jan 1. PMID:
34982963
Article Published Date
: Feb 14, 2022
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Carbon 60
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antineoplastic Agents
,
Antioxidants
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 alpha downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells.
Apr 18, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Acta Biochim Biophys Sin (Shanghai). 2023 Apr 19 ;55(4):587-600. PMID:
37092860
Article Published Date
: Apr 18, 2023
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
"Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats."
Feb 15, 2011
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2011 Feb 15 ;251(1):85-94. Epub 2010 Dec 15. PMID:
21167192
Article Published Date
: Feb 15, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Liver Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
Tumor Suppressor Protein p53 Upregulation
[+]
"Quercetin inhibits diethylnitrosamine-induced hepatic preneoplastic lesions in rats."
Jan 01, 2011
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2011 ;63(2):234-41. PMID:
21302176
Article Published Date
: Jan 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Quercetin
Diseases
:
Liver Cancer: Prevention
Pharmacological Actions
:
Chemopreventive
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Chemical: Lindane
[+]
6-Gingerol is a potent inducer of p53 reactivation in HPV positive cervical cancer cells through proteasome inhibition.
Nov 24, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2015 Nov 25. Epub 2015 Nov 25. PMID:
26621832
Article Published Date
: Nov 24, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Gingerol
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemosensitizer
,
Proteasome Inhibitors
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Reactivation Of Tumor Suppressor Gene
[+]
A compound from Allium hirtifolium could inhibit growth of MCF-7 and MDA-MB-231 cells through cell cycle arrest and apoptosis induction.
Aug 31, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Sep ;93:117-129. Epub 2017 Jun 16. PMID:
28624423
Article Published Date
: Aug 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Shallot
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-Angiogenic
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
A methanol extract of Salvia miltiorrhiza Bunge induced apoptosis in non-small cell lung cancer.
Mar 21, 2017
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2017 Mar 22 ;200:107-116. Epub 2017 Jan 12. PMID:
28088493
Article Published Date
: Mar 21, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Salvia miltiorrhiza
Diseases
:
Carcinoma: Non-Small-Cell Lung
,
Lung Cancer
Pharmacological Actions
:
Apoptotic
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
A multi-herbal product called Protandim exhibits chemopreventive properties in a mouse model of skin cancer.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: PLoS One. 2010;5(7):e11902. Epub 2010 Jul 30. PMID:
20689586
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Ashwagandha
,
Bacopa
,
Green Tea
,
Milk Thistle
,
Protandim
,
Turmeric
Diseases
:
Skin Cancer
Pharmacological Actions
:
Apoptotic
,
Chemopreventive
,
Superoxide Dismutase Up-regulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
A multi-herbal product called Protandim has chemopreventive properties against skin cancer.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: PLoS One. 2009;4(4):e5284. Epub 2009 Apr 22. PMID:
19384424
Article Published Date
: Jan 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Ashwagandha
,
Bacopa
,
Green Tea
,
Milk Thistle
,
Protandim
,
Turmeric
Diseases
:
Oxidative Stress
,
Skin Cancer
Pharmacological Actions
:
Antioxidants
,
NF-kappa-B-inducing kinase (NIK) modulator
,
Superoxide Dismutase Up-regulation
,
Tumor Suppressor Protein p53 Upregulation
,
Vascular Cell Adhesion Molecule-1 Inhibitor
[+]
A water extract of the roots of Asparagus racemosus has a preventive effect on chemically-induced hepatocarcinogenesis.
Sep 01, 2008
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2008 Sep ;22(9):1175-82. PMID:
18729252
Article Published Date
: Sep 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Asparagus
Diseases
:
Liver Cancer: Prevention
Pharmacological Actions
:
Chemopreventive
,
Malondialdehyde Down-regulation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
Amelioration of combination of paclitaxel and di allyl sulfide on the alterations of Bcl2, P53 and apoptosis changes against 7,12 Di methyl benz (A) anthracene induced skin cancer.
Mar 31, 2021
Click here to read the entire abstract
Pubmed Data
: Indian J Clin Biochem. 2021 Apr ;36(2):143-150. Epub 2019 Mar 15. PMID:
33867704
Article Published Date
: Mar 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Diallyl sulfide
Diseases
:
Skin Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Chemothapeutic Synergy: Paclitaxel
[+]
American ginseng prevents and treats Ulcerative Colitis.
Sep 18, 2008
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2008 Sep 18. [Epub ahead of print] PMID:
18802031
Article Published Date
: Sep 18, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Ginseng (American)
Diseases
:
Colitis: Pseudomembranous
,
Ulcerative Colitis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Nitric Oxide Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Andrographolide radiosensitizes human ovarian cancer SKOV3 xenografts due to an enhanced apoptosis and autophagy.
Oct 31, 2015
Click here to read the entire abstract
Pubmed Data
: Tumour Biol. 2015 Nov ;36(11):8359-65. Epub 2015 May 28. PMID:
26014516
Article Published Date
: Oct 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Andrographis
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Radiosensitizer
,
Tumor Suppressor Protein p53 Upregulation
[+]
Antiproliferative activity and apoptotic efficiency of Syzygium cumini bark methanolic extract against EAC cells.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Anticancer Agents Med Chem. 2021 ;21(6):782-792. PMID:
32781964
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Jambul
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antioxidants
,
Apoptotic
,
Bcl-2 protein down-regulation
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
Apigenin exposure induces DNA damage, G2/M phase cell cycle arrest, p53 accumulation and apoptosis in kidney cancer cells.
Mar 20, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2017 Mar 21 ;8(12):19834-19842. PMID:
28423637
Article Published Date
: Mar 20, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Apigenin
Diseases
:
Kidney Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
MicroRNA modulator
,
Tumor Suppressor Protein p53 Upregulation
[+]
Aqueous extract from Pecan nut shell show activity against breast cancer cell line MCF-7 and Ehrlich ascites tumors.
Aug 10, 2017
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2017 Aug 11. Epub 2017 Aug 11. PMID:
28807853
Article Published Date
: Aug 10, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Pecan
Diseases
:
Breast Cancer
,
Ehrlich carcinoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
Astaxanthin intervention ameliorates cyclophosphamide-induced oxidative stress, DNA damage and early hepatocarcinogenesis in rat.
Feb 01, 2010
Click here to read the entire abstract
Pubmed Data
: Mutat Res. 2010 Feb ;696(1):69-80. Epub 2009 Dec 28. PMID:
20038455
Article Published Date
: Feb 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Chemotherapy-Induced Toxicity: Cyclophosphamide
,
DNA damage
,
Liver Damage
,
Oxidative Stress
Pharmacological Actions
:
Chemopreventive
,
Tumor Suppressor Protein p53 Upregulation
[+]
Astaxanthin provides a potential therapeutic value in pulmonary fibrosis treatment.
Aug 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cell Mol Med. 2015 Sep ;19(9):2215-31. Epub 2015 Jun 27. PMID:
26119034
Article Published Date
: Aug 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Fibrosis
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Baicalein inhibits cell proliferation and enhances apoptosis in human A549 cells and benzo(a)pyrene-induced pulmonary carcinogenesis in mice.
Mar 24, 2022
Click here to read the entire abstract
Pubmed Data
: J Biochem Mol Toxicol. 2022 Mar 25:e23053. Epub 2022 Mar 25. PMID:
35332611
Article Published Date
: Mar 24, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Baicalein
Diseases
:
Benzo[a]pyrene-induced Toxicity
,
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cyclin D1 Down-Regulation
,
Tumor Suppressor Protein p53 Upregulation
Problem Substances
:
Benzo(a)pyrene
[+]
Benzyl Isothiocyanate potentiates p53 signaling and antitumor effects against breast cancer.
Jan 09, 2017
Click here to read the entire abstract
Pubmed Data
: Sci Rep. 2017 Jan 10 ;7:40070. Epub 2017 Jan 10. PMID:
28071670
Article Published Date
: Jan 09, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Benzyl isothiocyanate
,
Isothiocyanates
Diseases
:
Breast Cancer
Pharmacological Actions
:
Tumor Suppressor Protein p53 Upregulation
[+]
Berbamine induces programmed cell death in human liver cancer cells and inhibits tumor growth in mice.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Asian Nat Prod Res. 2009;11(3):219-28. PMID:
19408145
Article Published Date
: Jan 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Liver Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Bioactive soybean components inhibit the growth and metastasis of androgen-sensitive human prostate tumors in mice
Oct 01, 2002
Click here to read the entire abstract
Pubmed Data
: Prostate. 2002 Oct 1;53(2):143-53. PMID:
12242729
Article Published Date
: Oct 01, 2002
Study Type
: Animal Study
Additional Links
Substances
:
Isoflavones
,
Soy Protein
Diseases
:
Androgen-Induced Diseases
,
Lung Cancer
,
Prostate Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
Both quercetin and isoliquiritigenin exhibited anti-cancer effects on Epstein-Barr virus associated gastric carcinoma.
Sep 25, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2016 Sep 26 ;21(10). Epub 2016 Sep 26. PMID:
27681719
Article Published Date
: Sep 25, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Isoliquiritigenin
,
Quercetin
Diseases
:
Epstein-Barr Virus Infections
,
Gastric Cancer
Pharmacological Actions
:
Apoptotic
,
Chemopreventive
,
Tumor Suppressor Protein p53 Upregulation
[+]
Bufadienolides induce p53-mediated apoptosis in esophageal squamous cell carcinoma cells.
Jan 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2018 Feb ;15(2):1566-1572. Epub 2017 Nov 21. PMID:
29434851
Article Published Date
: Jan 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Venom: Toad
Diseases
:
Esophageal Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Caffeine exhibits radioprotective properties in whole-body irradiated male mice.
Mar 01, 2003
Click here to read the entire abstract
Pubmed Data
: In Vivo. 2003 Mar-Apr;17(2):197-200. PMID:
12792986
Article Published Date
: Mar 01, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Caffeine
Diseases
:
Radiation Induced Illness
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Radioprotective
,
Tumor Suppressor Protein p53 Upregulation
[+]
Chemopreventive potential of phenolic compounds in oral carcinogenesis.
Sep 30, 2014
Click here to read the entire abstract
Pubmed Data
: Arch Oral Biol. 2014 Oct ;59(10):1101-7. Epub 2014 Jul 3. PMID:
25033381
Article Published Date
: Sep 30, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Apigenin
,
Catechin
,
Cocoa
,
Rosemary
Diseases
:
Oral Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Risk Reduction
[+]
Co-treatment with piperlongumine led to a 1.68-fold enhancement in docetaxel bioavailability in SD rats.
Sep 14, 2015
Click here to read the entire abstract
Pubmed Data
: J Pharm Sci. 2015 Sep 15. Epub 2015 Sep 15. PMID:
26372815
Article Published Date
: Sep 14, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Long Pepper
,
Piperlongumine
Diseases
:
Breast Cancer: Triple Negative
Pharmacological Actions
:
Cyclin D1 Down-Regulation
,
Cytotoxic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Chemotherapeutic Synergy: Docetaxel
[+]
Curcumin and resveratrol significantly modulated p53 post-translational modifications during gastric cancer.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Environ Pathol Toxicol Oncol. 2018 ;37(2):93-101. PMID:
30055545
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Resveratrol
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin exhibits anti-melanoma activity.
Mar 01, 2003
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2003 Mar;17(3):217-21. PMID:
19260281
Article Published Date
: Mar 01, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Melanoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin has anticancer, chemosensitization and radiosensitization effects in prostate cancer.
Mar 01, 2007
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2007 Mar 1;67(5):1988-96. PMID:
17332326
Article Published Date
: Mar 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Cancers: Drug Resistant
,
Prostate Cancer
Pharmacological Actions
:
Chemosensitizer
,
Radiosensitizer
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Drug: Gemcitabine
,
Drug Synergy
[+]
Curcumin inhibits chemically-induced liver cancer.
Nov 01, 2000
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2000 Nov;38(11):991-5. PMID:
11038236
Article Published Date
: Nov 01, 2000
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Chemically-Induced Liver Damage
,
Liver Cancer
Pharmacological Actions
:
Chemopreventive
,
Hepatoprotective
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin potentiated significant increase in Nrf2 activation. It restored activity of phase-II antioxidant enzymes like GST, GR, NQO1, and tumour suppressor p53 level.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(4):e0124000. Epub 2015 Apr 10. PMID:
25860911
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Liver Cancer
,
Liver Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
MicroRNA modulator
,
Nrf2 activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumol may be a potential compound for use in the development of novel triple-negative breast cancer therapeutics.
Jun 30, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2017 Jul ;14(1):1080-1088. Epub 2017 May 29. PMID:
28693277
Article Published Date
: Jun 30, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Curcumol
Diseases
:
Breast Cancer: Triple Negative
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Didymin induces Fas-mediated apoptotic pathway in human non-small-cell lung cancer cells.
May 31, 2010
Click here to read the entire abstract
Pubmed Data
: Lung Cancer. 2010 Jun ;68(3):366-74. Epub 2009 Sep 5. PMID:
19733932
Article Published Date
: May 31, 2010
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Carcinoma: Non-Small-Cell Lung
,
Lung Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Dietary phytochemicals have a beneficial effect on benign prostatic hyperplasia prevention.
Nov 30, 2016
Click here to read the entire abstract
Pubmed Data
: Appl Physiol Nutr Metab. 2016 Dec ;41(12):1303-1310. Epub 2016 Sep 27. PMID:
27849354
Article Published Date
: Nov 30, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Flaxseed
,
Lignans
Diseases
:
Prostatic Hyperplasia: Benign
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Cyclin D1 Down-Regulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.
Dec 30, 2010
Click here to read the entire abstract
Pubmed Data
: Br J Pharmacol. 2010 Dec 30. Epub 2010 Dec 30. PMID:
19041676
Article Published Date
: Dec 30, 2010
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Resveratrol
,
Vitamin C
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Antioxidants
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Stilbenes
[+]
Eastern prickly pear extract may be a promising candidate for treating human cervical carcinoma.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2015 Jan ;18(1):31-44. PMID:
25379883
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Prickly Pear Cactus
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Antioxidants
,
Cell cycle arrest
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
EGCG enhanced the anti-tumor effect of doxorubicine in bladder cancer.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Cell Dev Biol. 2020 ;8:606123. Epub 2020 Dec 23. PMID:
33425912
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Chemosensitizer
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Chemotherapeutic Synergy: Doxorubicin
[+]
Enhanced anticancer effect and reduced toxicity of doxorubicin in combination with thymoquinone.
Sep 06, 2017
Click here to read the entire abstract
Pubmed Data
: Eur J Pharm Sci. 2017 Sep 7 ;109:525-532. Epub 2017 Sep 7. PMID:
28890201
Article Published Date
: Sep 06, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Thymoquinone
Diseases
:
Breast Cancer
,
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Bcl-2 protein down-regulation
,
Chemoprotective Agents
,
Chemotherapeuticm
,
Tumor Suppressor Protein p53 Upregulation
[+]
Exercise alters the IGF axis in vivo and increases p53 protein in prostate tumor cells in vitro.
Jan 31, 2004
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Appl Physiol (1985). 2004 Feb ;96(2):450-4. PMID:
14715676
Article Published Date
: Jan 31, 2004
Study Type
: Animal Study
Additional Links
Diseases
:
Prostate Cancer
Therapeutic Actions
:
Exercise
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemopreventive
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Physical Activity
[+]
Galangin promotes cell apoptosis through suppression of H19 expression in hepatocellular carcinoma cells.
Jul 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Med. 2020 Aug ;9(15):5546-5557. Epub 2020 Jun 2. PMID:
32485786
Article Published Date
: Jul 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Garlic extract has anti-proliferating properties and can be used as an alternative mode of treatment and prevention for hepatocellular carcinoma.
Mar 31, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran J Basic Med Sci. 2022 Apr ;25(4):497-505. PMID:
35656070
Article Published Date
: Mar 31, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Garlic
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antioxidants
,
Antiproliferative
,
Chemopreventive
,
Tumor Suppressor Protein p53 Upregulation
Problem Substances
:
N-nitrosodiethylamine
[+]
Ginkgo biloba has a protective effect against rat liver carcinogenesis.
May 09, 2008
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2008 May 9 ;173(1):32-42. Epub 2008 Feb 12. PMID:
18367157
Article Published Date
: May 09, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Ginkgo biloba
Diseases
:
Liver Cancer: Prevention
Pharmacological Actions
:
Chemopreventive
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
Ginsenoside M1 induces apoptosis and inhibits the migration of human oral cancer cells.
Dec 18, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2020 Dec 19 ;21(24). Epub 2020 Dec 19. PMID:
33352689
Article Published Date
: Dec 18, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Oral Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2014 ;9(12):e115401. Epub 2014 Dec 18. PMID:
25521755
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Melanoma
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Histone deacetylase inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Green tea-derived theabrownin suppresses human non-small cell lung carcinoma.
Mar 06, 2022
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2022 Mar 7 ;291:115167. Epub 2022 Mar 7. PMID:
35271947
Article Published Date
: Mar 06, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Green Tea
,
Polyphenols
Diseases
:
Carcinoma: Non-Small-Cell Lung
Pharmacological Actions
:
Antiproliferative
,
Tumor Suppressor Protein p53 Upregulation
[+]
Hesperidin attenuates oxidative stress, inflammation, apoptosis, and cardiac dysfunction in sodium fluoride-induced cardiotoxicity.
Jul 31, 2022
Click here to read the entire abstract
Pubmed Data
: Cardiovasc Toxicol. 2022 Aug ;22(8):727-735. Epub 2022 May 23. PMID:
35606666
Article Published Date
: Jul 31, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Hesperidin
Diseases
:
Fluoride Toxicity
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Bcl-2 protein down-regulation
,
NF-kappaB Inhibitor
,
Superoxide Dismutase Up-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
Problem Substances
:
Sodium Fluoride
[+]
Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat.
Jun 15, 2001
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2001 Jun 15;421(3):149-56. PMID:
11516430
Article Published Date
: Jun 15, 2001
Study Type
: Animal Study
Additional Links
Substances
:
Huperzine
Diseases
:
Alzheimer's Disease
,
Cognitive Decline/Dysfunction
,
Neurodegenerative Diseases
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
,
Tumor Suppressor Protein p53 Upregulation
[+]
Induction of apoptosis of tumor cells by some potentiated homeopathic drugs.
May 31, 2012
Click here to read the entire abstract
Pubmed Data
: Integr Cancer Ther. 2012 Jun ;11(2):172-82. Epub 2011 Jul 19. PMID:
21771822
Article Published Date
: May 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Homeopathic Medicine: All
Diseases
:
Lymphoma
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Phytotherapy
[+]
Induction of p21 by EGCG could provide clinically useful normalization of salivary glands by promoting differentiation and reducing PCNA levels.
Jan 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Inflamm Allergy Drug Targets. 2014 Feb ;13(1):15-24. PMID:
24329914
Article Published Date
: Jan 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Autoimmune Diseases
,
Diabetes Mellitus: Type 1: Prevention
,
Sjogren's Syndrome
Pharmacological Actions
:
Anticarcinogenic Agents
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Intra-tumoral injection of TriCurin significantly inhibited tumor growth by 85.5%.
Jul 15, 2016
Click here to read the entire abstract
Pubmed Data
: Oncotarget. 2016 Jul 16. Epub 2016 Jul 16. PMID:
27437871
Article Published Date
: Jul 15, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Resveratrol
Diseases
:
Head and Neck Cancer
,
Human Papillomavirus (HPV)
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Chemopreventive
,
Tumor Suppressor Protein p53 Upregulation
[+]
Lupeol may orchestrate a bifurcated regulation of neoplastic growth and apoptosis in head and neck cancers.
Mar 31, 2017
Click here to read the entire abstract
Pubmed Data
: Cell Oncol (Dordr). 2017 Apr ;40(2):145-155. Epub 2016 Dec 30. PMID:
28039610
Article Published Date
: Mar 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Lupeol
Diseases
:
Head and Neck Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Luteolin and 5-flurouracil act synergistically to induce cellular weapons in experimentally induced solid ehrlich carcinoma
Aug 31, 2019
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2019 Sep 1 ;310:108740. Epub 2019 Jul 6. PMID:
31288002
Article Published Date
: Aug 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Luteolin
Diseases
:
Breast Cancer
Pharmacological Actions
:
Apoptotic
,
Autophagy Up-regulation
,
Cyclin D1 Down-Regulation
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Chemothapeutic Synergy: 5-flourouracil
[+]
Melatonin improves pro-survival signals and reduces pro-death signals in age-related impairments of neural processes.
Nov 01, 2008
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2008 Nov;45(4):497-505. Epub 2008 Aug 13. PMID:
18705649
Article Published Date
: Nov 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
,
Aging: Brain
,
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Melatonin inhibits oxidative stress and programmed cell death in fetal brains of hyperhomocysteinemic rat dams.
Oct 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2007 Oct;43(3):225-31. PMID:
17803518
Article Published Date
: Oct 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
High Homocysteine
,
Lipid Peroxidation
,
Oxidative Stress
,
Prenatal Nutrition: Prevention of Problems
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Neuroprotective Agents
,
Tumor Suppressor Protein p53 Upregulation
[+]
Melatonin triggered apoptosis in an in vivo model of ovarian cancer.
Nov 09, 2015
Click here to read the entire abstract
Pubmed Data
: Endocr Relat Cancer. 2015 Nov 10. Epub 2015 Nov 10. PMID:
26555801
Article Published Date
: Nov 09, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Oleanolic acid inhibits the growth of DU145, MCF-7, and U87 cancer cells.
May 28, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2018 May 29 ;9(41):26370-26386. Epub 2018 May 29. PMID:
29899865
Article Published Date
: May 28, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Oleanolic acid
Diseases
:
Breast Cancer
,
Glioblastoma
,
Prostate Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Pectic acid, a natural component of apple, can prevent metastasis in breast cancer cell lines.
Nov 30, 2016
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2016 Dec ;84:637-644. Epub 2016 Sep 30. PMID:
27697635
Article Published Date
: Nov 30, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Apple Pectin
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Preparation of morusin from Ramulus mori and its effects on mice with transplanted H22 hepatocarcinoma.
Oct 31, 2014
Click here to read the entire abstract
Pubmed Data
: Biofactors. 2014 Nov-Dec;40(6):636-45. Epub 2014 Nov 25. PMID:
25422054
Article Published Date
: Oct 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids
,
Mulberry
Diseases
:
Alcohol Toxicity
,
Liver Cancer
Pharmacological Actions
:
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
Protein phosphatase 2A mediates diosmin p53 activation to block hepato-cellular carcinoma HA22T cell proliferation and tumor growth.
Apr 30, 2012
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2012 May ;50(5):1802-10. Epub 2012 Jan 25. PMID:
22289577
Article Published Date
: Apr 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Diosmin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Pterostilbene is a potential chemoprevention agent for lung squamous cell carcinoma.
Jul 20, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2021 Jul 21 ;11(1):14862. Epub 2021 Jul 21. PMID:
34290382
Article Published Date
: Jul 20, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Pterostilbene
Diseases
:
Squamous cell carcinoma
Pharmacological Actions
:
Chemopreventive
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Quercetin has a protective effect on atherosclerosis via enhancement of autophagy.
Sep 30, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2019 Oct ;18(4):2451-2458. Epub 2019 Aug 5. PMID:
31555357
Article Published Date
: Sep 30, 2019
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Quercetin
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Autophagy Up-regulation
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth.
Jan 09, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Death Differ. 2016 10 ;23(10):1615-27. Epub 2016 Jun 3. PMID:
27258787
Article Published Date
: Jan 09, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Phenethyl isothiocyanate
Diseases
:
Cancers: All
Pharmacological Actions
:
Tumor Suppressor Protein p53 Upregulation
[+]
Resveratrol's nontoxic nature and broad anti-GBM effects make it a compelling candidate to supplement current GBM therapies.
Jul 14, 2016
Click here to read the entire abstract
Pubmed Data
: J Neurosurg. 2016 Jul 15:1-13. Epub 2016 Jul 15. PMID:
27419830
Article Published Date
: Jul 14, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Resveratrol
Diseases
:
Glioblastoma Multiforme
Pharmacological Actions
:
Antiproliferative
,
Chemotherapeutic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Cancer Stem Cells
[+]
Rosmarinic acid reverses non-small cell lung cancer cisplatin resistance by activating the MAPK signaling pathway.
Jan 26, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Phytother Res. 2020 Jan 27. Epub 2020 Jan 27. PMID:
31985119
Article Published Date
: Jan 26, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Rosmarinic acid
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Multidrug Resistance Gene Modulators
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Chemotherapeutic Synergy: Cisplatin
[+]
Rosmarinic acid suppresses inflammation, angiogenesis, and improves paclitaxel induced apoptosis in a breast cancer model.
Nov 30, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Appl Biomed. 2021 Dec ;19(4):202-209. Epub 2021 Oct 27. PMID:
34907739
Article Published Date
: Nov 30, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Rosemaric Acid
Diseases
:
Breast Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-Inflammatory Agents
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Chemothapeutic Synergy: Paclitaxel
[+]
Rutin protects the neural damage induced by transient focal ischemia in rats.
Oct 06, 2009
Click here to read the entire abstract
Pubmed Data
: Brain Res. 2009 Oct 6;1292:123-35. Epub 2009 Jul 22. PMID:
19631195
Article Published Date
: Oct 06, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Rutin
Diseases
:
Cerebral Ischemia
,
Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions
:
Antioxidants
,
Apoptotic
,
Neuroprotective Agents
,
Tumor Suppressor Protein p53 Upregulation
[+]
Seaweed Sargassum aquifolium extract ameliorates cardiotoxicity induced by doxorubicin.
Mar 31, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Environ Sci Pollut Res Int. 2023 Apr ;30(20):58226-58242. Epub 2023 Mar 28. PMID:
36977879
Article Published Date
: Mar 31, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Seaweed: Brown
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
,
Oxidative Stress
Pharmacological Actions
:
Cardioprotective
,
Chemoprotective Agents
,
Tumor Suppressor Protein p53 Upregulation
[+]
Selective anti-tumor activity of wogonin targeting the Warburg effect through stablizing p53.
Jul 17, 2018
Click here to read the entire abstract
Pubmed Data
: Pharmacol Res. 2018 Jul 18 ;135:49-59. Epub 2018 Jul 18. PMID:
30031170
Article Published Date
: Jul 17, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Wogonin
Diseases
:
Colon Cancer
,
Liver Cancer
,
Ovarian Cancer
Pharmacological Actions
:
Antiproliferative
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Warburg Effect
[+]
Selenium can trigger apoptosis in cancer stem like cells by modulation of arachidonic acid metabolism.
Jul 14, 2014
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2014 Jul 15 ;74(14):3890-901. Epub 2014 May 28. PMID:
24872387
Article Published Date
: Jul 14, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Selenium
Diseases
:
Acute Myeloid Leukemia: Stem Cell
,
Leukemia
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Stem Like Cells
Problem Substances
:
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]
Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression.
Sep 20, 2023
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2023 Sep 21 ;121:155109. Epub 2023 Sep 21. PMID:
37778247
Article Published Date
: Sep 20, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Sesamol
Diseases
:
Arthritis: Rheumatoid
Pharmacological Actions
:
Antiproliferative
,
Tumor Suppressor Protein p53 Upregulation
[+]
Silibinin mediates its protection against UVB-induced photodamage, inflammation and photocarcinogenesis partly through p53 activation
Oct 10, 2016
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2016 Oct 11. Epub 2016 Aug 11. PMID:
27729375
Article Published Date
: Oct 10, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Silibinin
Diseases
:
Skin Cancer: Prevention
,
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Photoprotective
,
Tumor Suppressor Protein p53 Upregulation
[+]
Spirulina inhibits hepatocellular carcinoma through activating p53 and apoptosis and suppressing oxidative stress and angiogenesis.
Jan 14, 2021
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2021 Jan 15 ;265:118827. Epub 2020 Nov 28. PMID:
33253720
Article Published Date
: Jan 14, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Spirulina
Diseases
:
Liver Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anticarcinogenic Agents
,
Antioxidants
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Synergistic effect of 5-fluorouracil and the flavanoid oroxylin A on HepG2 human hepatocellular carcinoma.
Jan 31, 2010
Click here to read the entire abstract
Pubmed Data
: Cancer Chemother Pharmacol. 2010 Feb ;65(3):481-9. Epub 2009 Jul 8. PMID:
19585117
Article Published Date
: Jan 31, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Liver Cancer
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Cyclooxygenase 2 Inhibitors
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Chemothapeutic Synergy: 5-flourouracil
[+]
Tannic acid ameliorates doxorubicin-induced cardiotoxicity and potentiates its anti-cancer activity.
Mar 14, 2011
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2011 Mar 15 ;251(3):191-200. Epub 2010 Dec 29. PMID:
21194538
Article Published Date
: Mar 14, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Tannic Acid
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
,
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Antioxidants
,
Chemosensitizer
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Chemotherapeutic Synergy: Doxorubicin
[+]
Tatariside possess notable antitumor effects against HCC and might play a favorable role in drug combination therapy against tumors with protective effect on liver.
Jul 14, 2015
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2015 Jul 15 ;22(7-8):730-6. Epub 2015 May 23. PMID:
26141759
Article Published Date
: Jul 14, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Buckwheat
Diseases
:
Chemotherapy-Induced Toxicity: Cyclophosphamide
,
Liver Cancer
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Chemoprotective Agents
,
Tumor Suppressor Protein p53 Upregulation
Problem Substances
:
Cyclophosphamide
[+]
The anti-osteosarcoma effect from panax notoginseng saponins.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cancer. 2021 ;12(21):6383-6392. Epub 2021 Aug 30. PMID:
34659528
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Panax Notoginseng
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
The combined effect of pomegranate extract and tangeretin on the DMBA-induced breast cancer model.
Dec 12, 2020
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2020 Dec 13:108566. Epub 2020 Dec 13. PMID:
33326843
Article Published Date
: Dec 12, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Pomegranate
,
Tangeretin
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclin D1 Down-Regulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
The herbal preparation Shemamruthaa had antiproliferative and apoptotic effects on chemically induced breast cancer.
Sep 30, 2015
Click here to read the entire abstract
Pubmed Data
: J Evid Based Complementary Altern Med. 2015 Oct ;20(4):259-68. Epub 2015 Apr 17. PMID:
25888591
Article Published Date
: Sep 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Shemamruthaa
Diseases
:
Breast Cancer
,
Breast Cancer: Chemically-Induced
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Caspase-3 Activation
,
Caspase-9 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
The preventive effects of hyperoside on lung cancer in vitro.
Sep 30, 2016
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2016 Oct ;83:381-391. Epub 2016 Jul 14. PMID:
27419887
Article Published Date
: Sep 30, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Cancer Metastasis
,
Lung Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
The pro-apoptotic effect of FO in Walker 256 tumor is related with specifics cleaved caspases.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Lipids Health Dis. 2015 ;14(1):94. Epub 2015 Aug 25. PMID:
26303118
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Fish Oil
,
Polyunsaturated Fatty Acids (PUFAs)
Diseases
:
Tumors
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Caspase-3 Activation
,
Caspase-7 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
The role of the aqueous extract Polypodium leucotomos in photoprotection.
May 19, 2020
Click here to read the entire abstract
Pubmed Data
: Photochem Photobiol Sci. 2020 May 20. Epub 2020 May 20. PMID:
32432303
Article Published Date
: May 19, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Polypodium leucotomos
Diseases
:
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Photoprotective
,
Tumor Suppressor Protein p53 Upregulation
[+]
These findings identify Magnolol as a promising candidate with anti-microtubule polymerization activity for NSCLC treatment.
Jul 25, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2017 Jul 26 ;42(5):1789-1801. Epub 2017 Jul 26. PMID:
28746938
Article Published Date
: Jul 25, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Magnolol
Diseases
:
Carcinoma: Non-Small-Cell Lung
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
These findings suggested that the cancer-preventive effect of Angelica sinensis root extract may be stage-dependent in the process of carcinogenesis.
Aug 10, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2017 Aug 11 ;18(8). Epub 2017 Aug 11. PMID:
28800083
Article Published Date
: Aug 10, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Angelica
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antioxidants
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
These results indicated that diosgenin was effective in inhibiting testosterone propionate-induced prostate enlargement.
Nov 30, 2016
Click here to read the entire abstract
Pubmed Data
: J Huazhong Univ Sci Technolog Med Sci. 2016 Dec ;36(6):806-810. Epub 2016 Dec 7. PMID:
27924509
Article Published Date
: Nov 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Diosgenin
Diseases
:
Oxidative Stress
,
Prostatic Hyperplasia: Benign
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Malondialdehyde Down-regulation
,
Superoxide Dismutase Up-regulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
These results suggest that piperine free P. nigrum extracts can enhance breast cancer cell response to phytochemicals.
May 03, 2016
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2016 May 4. Epub 2016 May 4. PMID:
27155135
Article Published Date
: May 03, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Black Pepper
Diseases
:
Breast Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Tumor Suppressor Protein p53 Upregulation
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Bioenhancer
,
Natural Substance Synergy
[+]
This study indicated an apoptosis-enhancing capability of calcarea carbonica in cancer cells by strengthening the immune system as well as the cross-talk of various pro- and anti-apoptotic factors.
Dec 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2013 ;13:230. Epub 2013 Sep 21. PMID:
24053127
Article Published Date
: Dec 31, 2012
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Homeopathic Medicine: All
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Immunomodulatory
,
Tumor Suppressor Protein p53 Upregulation
[+]
β-phenylethyl isothiocyanate could be a functional ingredient for oral cancer prevention.
Jul 16, 2018
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2018 Jul 17 ;9(7):3640-3656. PMID:
29923573
Article Published Date
: Jul 16, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Isothiocyanates
Diseases
:
Oral Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Anticancer effects of oridonin on colon cancer are mediated via BMP7/p38 MAPK/p53 signaling.
Oct 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Oncol. 2018 Nov ;53(5):2091-2101. Epub 2018 Aug 16. PMID:
30132514
Article Published Date
: Oct 31, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Oridonin
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Tumor Suppressor Protein p53 Upregulation
[+]
Isoalantolactone inhibits UM-SCC-10A cell growth via cell cycle arrest and apoptosis induction
Dec 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2013 ;8(9):e76000. Epub 2013 Sep 30. PMID:
24098753
Article Published Date
: Dec 31, 2012
Study Type
: In Vitro Study
Additional Links
Substances
:
Elecampane
Diseases
:
Head and Neck Cancer
,
Squamous cell carcinoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
MDM2 as a target for ellagic acid‑mediated suppression of prostate cancer cells in vitro.
Aug 31, 2020
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2020 Sep ;44(3):1255-1265. Epub 2020 Jun 26. PMID:
32705219
Article Published Date
: Aug 31, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Ellagic Acid
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Oridonin synergizes with Nutlin-3 in osteosarcoma cells by modulating the levels of multiple Bcl-2 family proteins.
May 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Tumour Biol. 2017 Jun ;39(6):1010428317701638. PMID:
28618955
Article Published Date
: May 31, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Oridonin
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells.
Jul 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Pharmacother. 2020 Aug ;128:110243. Epub 2020 May 27. PMID:
32470748
Article Published Date
: Jul 31, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Piperlongumine
Diseases
:
Intestinal Cancer
Pharmacological Actions
:
Bcl-2 protein down-regulation
,
Chemosensitizer
,
P21 Activation
,
Survivin Down-Regulation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Chemothapeutic Synergy: Paclitaxel
[+]
Resveratrol induced premature senescence and inhibited epithelial-mesenchymal transition of cancer cells via induction of tumor suppressor Rad9.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2019 ;14(7):e0219317. Epub 2019 Jul 16. PMID:
31310624
Article Published Date
: Dec 31, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Resveratrol
Diseases
:
Breast Cancer
,
Cancer Metastasis
,
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Enzyme Inhibitors
,
Tumor Suppressor Protein p53 Upregulation
[+]
This review is the succinct appraisal of the pertinent articles on the mechanisms of anti-tumor properties of wogonin.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Chin J Nat Med. 2017 Jan ;15(1):15-40. PMID:
28259249
Article Published Date
: Dec 31, 2016
Study Type
: Review
Additional Links
Substances
:
Wogonin
Diseases
:
Cancers: All
,
Cancers: Drug Resistant
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Phytotherapy
[+]
"Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class I histone deacetylases."
Jun 30, 2012
Click here to read the entire abstract
Pubmed Data
: Int J Oncol. 2012 Jul ;41(1):353-61. Epub 2012 Apr 26. PMID:
22552582
Article Published Date
: Jun 30, 2012
Study Type
: In Vitro Study
Additional Links
Substances
:
Catechin
,
Polyphenols
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Apoptotic
,
Histone deacetylase inhibitor
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Epigenetic Modification
,
Plant Extracts
[+]
"Mitochondria: more than just a powerhouse."
Jul 25, 2006
Click here to read the entire abstract
Pubmed Data
: Curr Biol. 2006 Jul 25 ;16(14):R551-60. PMID:
16860735
Article Published Date
: Jul 25, 2006
Study Type
: Review
Additional Links
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Mitochondria
[+]
20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Des Devel Ther. 2015 ;9:3969-87. Epub 2015 Aug 10. PMID:
26309394
Article Published Date
: Dec 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Gallbladder Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
3,3'-diindolylmethane exerts antiproliferation and apoptosis induction by TRAF2-p38 axis in gastric cancer.
Dec 31, 2020
Click here to read the entire abstract
Pubmed Data
: Anticancer Drugs. 2021 02 1 ;32(2):189-202. PMID:
33315588
Article Published Date
: Dec 31, 2020
Study Type
: In Vitro Study
Additional Links
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
6-shogaol induces cancer cell death by inducing G2/M cell cycle arrest and apoptosis
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Am J Chin Med. 2015 ;43(4):743-56. Epub 2015 Jun 28. PMID:
26119958
Article Published Date
: Dec 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
6-Shogaol
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
,
Tumor Suppressor Protein p53 Upregulation
[+]
6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS.
Nov 20, 2018
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2018 Nov 21. Epub 2018 Nov 21. PMID:
30483736
Article Published Date
: Nov 20, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
6-Shogaol
Diseases
:
Liver Cancer
Pharmacological Actions
:
Apoptotic
,
Chemosensitizer
,
Tumor Suppressor Protein p53 Upregulation
[+]
A betanin enriched red beetroot extract induced apoptosis and autophagic cell death in MCF-7 cells.
Oct 13, 2015
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2015 Oct 14. Epub 2015 Oct 14. PMID:
26463240
Article Published Date
: Oct 13, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Beet
,
Betanins
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
,
Selective Cytotoxicity
[+]
A carotenoid extract was effective at inhibiting growth of HT-29 colon cancer cells.
Mar 06, 2017
Click here to read the entire abstract
Pubmed Data
: Nanotechnology. 2017 Mar 7 ;28(13):135103. Epub 2017 Mar 7. PMID:
28266352
Article Published Date
: Mar 06, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Goji
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
A hot water extract of Chlorella vulgaris could induce 100% inhibition of proliferation and 70% apoptosis rate against HepG2 cells in this study.
Dec 31, 2009
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Clinics (Sao Paulo). 2010 ;65(12):1371-7. PMID:
21340229
Article Published Date
: Dec 31, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Chlorella (Algae)
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Chemopreventive
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
A lyophilized grape extract comparable to putative dietary doses induced important morphology changes, migration inhibition, downregulation of undifferentiated stem/stem-like cells markers and EMT.
Mar 31, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2015 Apr ;67(3):494-503. Epub 2015 Feb 23. PMID:
25705818
Article Published Date
: Mar 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Anthocyanins
,
Flavonoids
,
Grape
,
Polyphenols
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antioxidants
,
Antiproliferative
,
Cell cycle arrest
,
E-cadherin down-regulation
,
Nrf2 activation
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Cancer Stem Cells
,
Dietary Doses
,
Plant Extracts
[+]
A methanolic extract of C. militaris at the concentration significantly inhibited cell proliferation and induced apoptosis of NCI-H460 cells.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2015 ;20(8):13927-40. Epub 2015 Jul 31. PMID:
26263965
Article Published Date
: Dec 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Cordyceps Militaris
Diseases
:
Carcinoma: Non-Small-Cell Lung
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
A methoxyflavanone derivative from Perilla frutescens induces p53-mediated G2/M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma.
Jul 13, 2017
Click here to read the entire abstract
Pubmed Data
: Cytotechnology. 2017 Jul 14. Epub 2017 Jul 14. PMID:
28710570
Article Published Date
: Jul 13, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Perilla
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
A methoxyflavanone from Perilla frutescens induces cellular senescence in A549 human lung adenocarcinoma cells.
Aug 17, 2022
Click here to read the entire abstract
Pubmed Data
: Biol Pharm Bull. 2022 Aug 18. Epub 2022 Aug 18. PMID:
35979561
Article Published Date
: Aug 17, 2022
Study Type
: In Vitro Study
Additional Links
Substances
:
Perilla
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Selective Antiproliferation
[+]
A review of the molecular targets of curcumin in breast cancer.
Nov 18, 2018
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2018 Nov 19. Epub 2018 Nov 19. PMID:
30483727
Article Published Date
: Nov 18, 2018
Study Type
: Review
Additional Links
Substances
:
Curcumin
Diseases
:
Breast Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-Inflammatory Agents
,
Anti-metastatic
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
A synergistic induction of apoptosis and inhibition of cell proliferation was observed in human colorectal cancer cells treated with the combination of capsaicin and DIM.
May 05, 2015
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2015 May 6 ;63(17):4297-304. Epub 2015 Apr 22. PMID:
25876645
Article Published Date
: May 05, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Capsaicin
Diseases
:
Colorectal Cancer
,
Colorectal Cancer: Prevention
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemopreventive
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dietary Concentrations
,
Natural Substance Synergy
[+]
Acacetin induces apoptosis in human gastric carcinoma cells.
Feb 08, 2005
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2005 Feb 9 ;53(3):620-30. PMID:
15686411
Article Published Date
: Feb 08, 2005
Study Type
: In Vitro Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Acacetin inhibits the proliferation of Hep G2 by blocking cell cycle progression and inducing apoptosis.
Feb 29, 2004
Click here to read the entire abstract
Pubmed Data
: Biochem Pharmacol. 2004 Mar 1 ;67(5):823-9. PMID:
15104235
Article Published Date
: Feb 29, 2004
Study Type
: In Vitro Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Acacetin-induced cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells.
Aug 19, 2004
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2004 Aug 20 ;212(1):53-60. PMID:
15246561
Article Published Date
: Aug 19, 2004
Study Type
: In Vitro Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Carcinoma: Non-Small-Cell Lung
,
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Acteoside as a potential therapeutic option for primary hepatocellular carcinoma: a preclinical study.
Sep 28, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Cancer. 2020 Sep 29 ;20(1):936. Epub 2020 Sep 29. PMID:
32993568
Article Published Date
: Sep 28, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Verbascoside
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Alantolactone induces activation of apoptosis in human hepatoma cells.
Aug 31, 2012
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2012 Sep ;50(9):3313-9. Epub 2012 Jun 18. PMID:
22721982
Article Published Date
: Aug 31, 2012
Study Type
: In Vitro Study
Additional Links
Substances
:
Elecampane
Diseases
:
Liver Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Alantolactone inhibits stem-like cell phenotype, chemoresistance and metastasis in PC3 cells.
Nov 30, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Res Pharm Sci. 2020 Dec ;15(6):551-562. Epub 2020 Nov 27. PMID:
33828598
Article Published Date
: Nov 30, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Elecampane
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Anti-metastatic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Allicin inhibited proliferation of glioblastoma cells in vitro.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Manag Res. 2020 ;12:7305-7317. Epub 2020 Aug 17. PMID:
32884345
Article Published Date
: Dec 31, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Allicin
Diseases
:
Glioma
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antiproliferative
,
Interleukin-6 Downregulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Aloe-emodin may have therapeutic activity in skin cancer.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: Chem Res Toxicol. 2009 Dec;22(12):2017-28. PMID:
19928967
Article Published Date
: Dec 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Aloe Vera
,
Emodin
Diseases
:
Skin Cancer
,
Skin Cancer: Squamous Cell
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Drug: 5-flourouracil
,
Selective Cytotoxicity
[+]
Aloin promotes A549 cell apoptosis via the reactive oxygen species‑mitogen activated protein kinase signaling pathway and p53 phosphorylation.
Oct 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2017 Nov ;16(5):5759-5768. Epub 2017 Aug 29. PMID:
28901386
Article Published Date
: Oct 31, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Aloe Vera
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Amygdalin is a natural anti-cancer agent which can be used for the treatment of hepatocellular carcinoma.
Jan 18, 2020
Click here to read the entire abstract
Pubmed Data
: Anticancer Agents Med Chem. 2020 Jan 19. Epub 2020 Jan 19. PMID:
31958042
Article Published Date
: Jan 18, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Amygdalin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
An analogue of anandamide Met-F-AEA could have significance in providing a basis for the management of thyroid carcinomas.
Mar 31, 2010
Click here to read the entire abstract
Pubmed Data
: Invest New Drugs. 2010 Apr ;28(2):115-23. Epub 2009 Feb 3. PMID:
19189054
Article Published Date
: Mar 31, 2010
Study Type
: In Vitro Study
Additional Links
Diseases
:
Thyroid Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Cannabinoid Receptors
[+]
An antioxidant rich fraction of white mulberry stem bark inhibits the growth of Ehrlich ascites carcinoma cells.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016 ;11(12):e0167536. Epub 2016 Dec 9. PMID:
27936037
Article Published Date
: Dec 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
White Mulberry
Diseases
:
Ehrlich carcinoma
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Bcl-xL down-regulation
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
An ethanol extract of chaga mushroom inhibits the cell proliferation and induced cell cycle arrest in a dose dependent manner.
Mar 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutr Res Pract. 2015 Apr ;9(2):111-6. Epub 2015 Mar 12. PMID:
25861415
Article Published Date
: Mar 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Chaga Mushroom (Inonotus obliquus)
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
An ethanol extract of Cordyceps militaris was highly cytotoxic to human colorectal carcinoma RKO cells and inhibited the growth of tumor in xenograft model.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Daru. 2015 ;23:35. Epub 2015 Jul 4. PMID:
26141646
Article Published Date
: Dec 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Cordyceps Militaris
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
An extract of wheatgrass inhibits human laryngeal cancer cell proliferation via cell cycle G1 arrest and p53 induction.
Apr 30, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharmacogn Mag. 2015 May ;11(Suppl 1):S139-47. PMID:
26109759
Article Published Date
: Apr 30, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Wheat Grass
Diseases
:
Laryngeal Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer.
Feb 29, 2012
Click here to read the entire abstract
Pubmed Data
: Clin Exp Pharmacol Physiol. 2012 Mar ;39(3):300-10. PMID:
22017767
Article Published Date
: Feb 29, 2012
Study Type
: Review
Additional Links
Substances
:
Andrographis
Diseases
:
Arthritis
,
Asthma
,
Cancers: All
,
Inflammation
,
Stroke
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-Inflammatory Agents
,
Antiproliferative
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
Andrographolide causes p53-independent HCC cell death through p62 accumulation and impaired DNA damage repair.
Nov 30, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Phytomedicine. 2023 Dec ;121:155089. Epub 2023 Sep 15. PMID:
37738908
Article Published Date
: Nov 30, 2023
Study Type
: In Vitro Study
Additional Links
Substances
:
Andrographis
Diseases
:
Liver Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Andrographolide enhances 5-fluorouracil-induced programmed cell death in liver cancer cells.
Apr 18, 2009
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2009 Apr 18;276(2):180-8. Epub 2008 Dec 20. PMID:
19097688
Article Published Date
: Apr 18, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Andrographis
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Drug-Plant-Vitamin Synergies
[+]
Andrographolide induces apoptosis in gastric cancer cells through reactivation of p53 and inhibition of Mdm-2.
Aug 31, 2021
Click here to read the entire abstract
Pubmed Data
: Dokl Biochem Biophys. 2021 Sep ;500(1):393-401. Epub 2021 Oct 25. PMID:
34697748
Article Published Date
: Aug 31, 2021
Study Type
: In Vitro Study
Additional Links
Substances
:
Andrographolide
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Andrographolide induces G2/M cell cycle arrest and apoptosis in human glioblastoma.
Oct 07, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2022 Oct 8 ;27(19). Epub 2022 Oct 8. PMID:
36235222
Article Published Date
: Oct 07, 2022
Study Type
: In Vitro Study
Additional Links
Substances
:
Andrographolide
Diseases
:
Glioblastoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Andrographolide sensitized bladder cancer cells to TRAIL-mediated apoptosis.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Biol Sci. 2019 ;15(3):688-700. Epub 2019 Jan 24. PMID:
30745855
Article Published Date
: Dec 31, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Andrographolide
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Apoptotic
,
Chemosensitizer
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Annurca apple polyphenol extract strongly inhibits the proliferation of MCF-7 cells by inducing G2/M cell cycle arrest and apoptosis.
Aug 31, 2017
Click here to read the entire abstract
Pubmed Data
: Int J Oncol. 2017 Sep ;51(3):939-948. Epub 2017 Jul 31. PMID:
28766690
Article Published Date
: Aug 31, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Apple Polyphenols
Diseases
:
Breast Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Cyclin D1 Down-Regulation
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Anti-colorectal cancer effects of probiotic-derived p8 protein.
Jan 18, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Genes (Basel). 2019 08 19 ;10(8). Epub 2019 Aug 19. PMID:
31430963
Article Published Date
: Jan 18, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Probiotics
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Anti-proliferative and apoptosis-inducing activity of Acacia modesta and Opuntia monocantha extracts on HeLa cells.
Sep 30, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Asian Pac J Cancer Prev. 2020 Oct 1 ;21(10):3125-3131. Epub 2020 Oct 1. PMID:
33112576
Article Published Date
: Sep 30, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Prickly Pear Cactus
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Antioxidants
,
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Anticancer effects and potential mechanisms of ginsenoside Rh2 in various cancer types.
Mar 31, 2021
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2021 Apr ;45(4):1-10. Epub 2021 Mar 2. PMID:
33649861
Article Published Date
: Mar 31, 2021
Study Type
: Review
Additional Links
Substances
:
Ginsenosides
Diseases
:
Cancers: All
Pharmacological Actions
:
Antiproliferative
,
Chemotherapeutic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Anticancer potential of Carica papaya Linn black seed extract against human colon cancer cell line.
Jul 28, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Med Ther. 2023 Jul 29 ;23(1):271. Epub 2023 Jul 29. PMID:
37516866
Article Published Date
: Jul 28, 2023
Study Type
: In Vitro Study
Additional Links
Substances
:
Papaya
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Bcl-2 protein down-regulation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
Anticancer potential of myricetin bulk and nano forms in vitro in lymphocytes from myeloma patients.
Oct 29, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Arch Toxicol. 2020 Oct 30. Epub 2020 Oct 30. PMID:
33128380
Article Published Date
: Oct 29, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Myricetin
Diseases
:
Multiple Myeloma
Pharmacological Actions
:
Apoptotic
,
Bax/Bcl2 Ratio: Decrease
,
Tumor Suppressor Protein p53 Upregulation
[+]
Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-kappaB and p53 modulation.
Aug 31, 2008
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Cancer Ther. 2008 Sep ;7(9):2692-702. PMID:
18790751
Article Published Date
: Aug 31, 2008
Study Type
: In Vitro Study
Additional Links
Substances
:
Xanthohumol
Diseases
:
Acute Myeloid Leukemia
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Antineoplaston A10 (synthetic) induced programmed cell death in human liver cancer cells.
Jul 01, 2007
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Anticancer Res. 2007 Jul-Aug;27(4B):2427-31. PMID:
17695534
Article Published Date
: Jul 01, 2007
Study Type
: In Vitro Study
Additional Links
Diseases
:
Liver Cancer
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Antiproliferative activity of combined biochanin A and ginsenoside Rh2 on MDA-MB-231 and MCF-7 human breast cancer cells.
Nov 07, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2018 Nov 8 ;23(11). Epub 2018 Nov 8. PMID:
30413008
Article Published Date
: Nov 07, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Biochanin A
,
Ginsenosides
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Antiproliferative
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Natural Substance Synergy
[+]
Antitumorigenic effect of damnacanthal on melanoma cell viability through p53 and NF-κB/caspase-3 signaling pathways.
Oct 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2018 Nov ;16(5):6039-6044. Epub 2018 Sep 3. PMID:
30333875
Article Published Date
: Oct 31, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Damnacanthal
Diseases
:
Melanoma
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antiproliferative
,
Apoptotic
,
NF-kappaB Inhibitor
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Apoptotic potential of glucomoringin isothiocyanate isolated from Moringa oleifera seeds on human prostate cancer cells.
Apr 03, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2023 Apr 4 ;28(7). Epub 2023 Apr 4. PMID:
37049977
Article Published Date
: Apr 03, 2023
Study Type
: In Vitro Study
Additional Links
Substances
:
Moringa oleifera
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Aqueous extract of Curcuma aromatica induces apoptosis and G2/M arrest in human colon carcinoma.
Jan 31, 2011
Click here to read the entire abstract
Pubmed Data
: Cancer Biother Radiopharm. 2011 Feb ;26(1):97-104. Epub 2011 Feb 24. PMID:
21348775
Article Published Date
: Jan 31, 2011
Study Type
: In Vitro Study
Additional Links
Substances
:
Turmeric
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
Artemisinin could be an alternative treatment for oral squamous cell carcinoma.
Jun 30, 2004
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Anticancer Res. 2004 Jul-Aug;24(4):2153-60. PMID:
15330155
Article Published Date
: Jun 30, 2004
Study Type
: In Vitro Study
Additional Links
Substances
:
Artemisinin
Diseases
:
Oral Cancer
,
Squamous cell carcinoma
Pharmacological Actions
:
Antineoplastic Agents
,
Bcl-2 protein down-regulation
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Artemisinin inhibits gastric cancer cell proliferation through upregulation of p53.
Jan 31, 2014
Click here to read the entire abstract
Pubmed Data
: Tumour Biol. 2014 Feb ;35(2):1403-9. PMID:
24078446
Article Published Date
: Jan 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Artemisinin
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Ashwaganda leaf extract exhibits selective killing of cancer cells.
May 01, 2006
Click here to read the entire abstract
Pubmed Data
: Mol Carcinog. 2006 May;45(5):320-32. PMID:
17404115
Article Published Date
: May 01, 2006
Study Type
: In Vitro Study
Additional Links
Substances
:
Ashwagandha
Diseases
:
Tumors
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
,
Selective Cytotoxicity
[+]
Asiatic acid may be a valuable agent for the therapeutic intervention of human hepatomas.
Nov 30, 2002
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2002 Dec 1 ;186(1):83-91. PMID:
12183079
Article Published Date
: Nov 30, 2002
Study Type
: In Vitro Study
Additional Links
Substances
:
Asiatic Acid
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Asparagus racemosus and Geodorum densiflorum lectins induce apoptosis in cancer cells by altering proteins and genes expression.
Nov 29, 2021
Click here to read the entire abstract
Pubmed Data
: Int J Biol Macromol. 2021 Nov 30 ;191:646-656. Epub 2021 Sep 25. PMID:
34582909
Article Published Date
: Nov 29, 2021
Study Type
: In Vitro Study
Additional Links
Substances
:
Asparagus
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Attenuating role of withaferin A in the proliferation and migration of lung cancer cells.
Feb 28, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2021 Mar ;21(3):232. Epub 2021 Jan 26. PMID:
33613721
Article Published Date
: Feb 28, 2021
Study Type
: In Vitro Study
Additional Links
Substances
:
Ashwagandha
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
MicroRNA modulator
,
Tumor Suppressor Protein p53 Upregulation
[+]
Augmentation of radiation-induced apoptosis by ellagic acid.
Feb 28, 2010
Click here to read the entire abstract
Pubmed Data
: Cancer Invest. 2010 Mar ;28(3):323-30. PMID:
19863348
Article Published Date
: Feb 28, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Ellagic Acid
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Antioxidants
,
Apoptotic
,
Radiosensitizer
,
Tumor Suppressor Protein p53 Upregulation
[+]
Bamboo extract treatment significantly suppressed the viability of osteosarcoma 143B cells in vitro.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Des Devel Ther. 2014 ;8:1577-84. Epub 2014 Sep 24. PMID:
25284987
Article Published Date
: Dec 31, 2013
Study Type
: In Vitro Study
Additional Links
Substances
:
Bamboo
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
Bavachinin mitigates DMH induced colon cancer in rats by altering p53/Bcl2/BAX signaling associated with apoptosis,
Mar 31, 2021
Click here to read the entire abstract
Pubmed Data
: Biotech Histochem. 2021 Apr ;96(3):179-190. Epub 2020 Jul 15. PMID:
32664769
Article Published Date
: Mar 31, 2021
Study Type
: In Vitro Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Colon Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Berbamine induced SMMC-7721 cell apoptosis.
Jan 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Feb ;15(2):1894-1901. Epub 2017 Dec 15. PMID:
29434780
Article Published Date
: Jan 31, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Berbamine
Diseases
:
Liver Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Berberine could be a potential adjunct for the treatment of gastrointestinal cancers.
Aug 19, 2018
Click here to read the entire abstract
Pubmed Data
: J Cell Biochem. 2018 Aug 20. Epub 2018 Aug 20. PMID:
30125974
Article Published Date
: Aug 19, 2018
Study Type
: Review
Additional Links
Substances
:
Berberine
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Apoptotic
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Berberine induces cell cycle arrest and programmed cell death in human osteosarcoma cells.
Mar 09, 2009
Click here to read the entire abstract
Pubmed Data
: Mutat Res. 2009 Mar 9;662(1-2):75-83. Epub 2008 Dec 31. PMID:
19159633
Article Published Date
: Mar 09, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Berberine inhibited human chondrosarcoma cell line (HTB-94) proliferation in a concentration-dependent manner.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Res. 2015 ;22(3):147-57. PMID:
26168133
Article Published Date
: Dec 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Chondrosarcoma
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dose Response
[+]
Berberine inhibits human neuroblastoma cell growth through induction of programmed cell death.
Nov 01, 2008
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2008 Nov-Dec;28(6A):3777-84. PMID:
19189664
Article Published Date
: Nov 01, 2008
Study Type
: In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Neuroblastoma
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Berberine may have potential applications as a chemotherapeutic agent for the management of head and neck squamous carcinoma.
Sep 24, 2015
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2015 Sep 25. Epub 2015 Sep 25. PMID:
26503508
Article Published Date
: Sep 24, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Head and Neck Cancer
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Berberis vulgaris fruit could be a reliable anti-leukaemic drug and candidate for anticancer therapy.
Mar 31, 2015
Click here to read the entire abstract
Pubmed Data
: J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):395-9. PMID:
26122228
Article Published Date
: Mar 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Barberry
Diseases
:
Leukemia
Pharmacological Actions
:
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Bergamot juice could reduce the growth of human hepatocellular carcinoma HepG2 cells.
Jan 03, 2016
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2016 Jan 4. Epub 2016 Jan 4. PMID:
26764233
Article Published Date
: Jan 03, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Bergamot orange
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
NF-kappaB Inhibitor
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Beta-elemene has antitumor activity against both platinum-sensitive and resistant ovarian cancer cells.
Jul 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Anticancer Res. 2012 Aug ;32(8):3103-13. PMID:
22843880
Article Published Date
: Jul 31, 2012
Study Type
: In Vitro Study
Additional Links
Substances
:
Beta-Elemene
Diseases
:
Cancers: Drug Resistant
,
Ovarian Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Beta-tocotrienol exhibits more cytotoxic effects than gamma-tocotrienol on breast cancer cells.
Jan 08, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomolecules. 2020 04 9 ;10(4). Epub 2020 Apr 9. PMID:
32283796
Article Published Date
: Jan 08, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin E
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Betulinic acid Inhibits cell proliferation in human oral squamous cell carcinoma.
Aug 06, 2017
Click here to read the entire abstract
Pubmed Data
: Oncol Res. 2017 Aug 7 ;25(7):1141-1152. Epub 2017 Jan 20. PMID:
28109089
Article Published Date
: Aug 06, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Betulinic acid
Diseases
:
Oral Cancer
,
Squamous cell carcinoma
Pharmacological Actions
:
Antiproliferative
,
Tumor Suppressor Protein p53 Upregulation
[+]
Betulinic acid-induced cytotoxicity in human breast tumor cell lines MCF-7 and T47D and its modification by tocopherol.
Sep 30, 2014
Click here to read the entire abstract
Pubmed Data
: Cancer Invest. 2014 Oct ;32(8):402-8. Epub 2014 Jul 14. PMID:
25019212
Article Published Date
: Sep 30, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Betulinic acid
,
Vitamin E
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Betulinic acid-mediated apoptosis in human prostate cancer cells involves p53 and NF-κB pathways.
Feb 09, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2017 Feb 10 ;22(2). Epub 2017 Feb 10. PMID:
28208611
Article Published Date
: Feb 09, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Betulinic acid
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Chemopreventive
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Bisdemethoxycurcumin enhances X-ray-induced apoptosis possibly through p53/Bcl-2 pathway.
Feb 28, 2017
Click here to read the entire abstract
Pubmed Data
: Mutat Res. 2017 Mar ;815:1-5. Epub 2017 Jan 11. PMID:
28283087
Article Published Date
: Feb 28, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Bisdemethoxycurcumin
Diseases
:
Leukemia: T-cell acute Lymphoblastic
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Radiosensitizer
,
Tumor Suppressor Protein p53 Upregulation
[+]
Bisphenol A prevents MCF-7 breast cell apoptosis via the inhibition of progesterone receptor transactivation.
Jun 30, 2023
Click here to read the entire abstract
Pubmed Data
: J Biochem Mol Toxicol. 2023 Jul ;37(7):e23367. Epub 2023 Apr 3. PMID:
37009741
Article Published Date
: Jun 30, 2023
Study Type
: In Vitro Study
Additional Links
Diseases
:
Bisphenol Toxicity
,
Breast Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Increased Risk
Problem Substances
:
Bisphenol A
[+]
Bixin and fuxoxanthin alone and in combination with cisplatin regulate ABCC1 and ABCC2 transcription in A549 lung cancer cells.
Dec 31, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Pharm Bioallied Sci. 2023 ;15(1):15-20. Epub 2023 Apr 14. PMID:
37313537
Article Published Date
: Dec 31, 2022
Study Type
: In Vitro Study
Additional Links
Substances
:
Bixin
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Tumor Suppressor Protein p53 Upregulation
[+]
Blueberry anthocyanins inhibited proliferation and induced apoptosis in oral cancer cells in a dose dependent manner.
Jun 19, 2014
Click here to read the entire abstract
Pubmed Data
: Yi Chuan. 2014 Jun 20 ;36(6):566-73. PMID:
24929515
Article Published Date
: Jun 19, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Anthocyanins
,
Blueberry
Diseases
:
Oral Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Caspase-9 Activation
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Epigenetic Modification
,
Methylation Downregulation
[+]
Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Biochem Cell Biol. 2017 02 ;95(1):99-109. Epub 2016 Nov 30. PMID:
28169560
Article Published Date
: Dec 31, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Lactoferrin
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Brazilian green propolis induced apoptosis in human lung cancer A549 cells through mitochondrial-mediated pathway.
Sep 30, 2015
Click here to read the entire abstract
Pubmed Data
: J Pharm Pharmacol. 2015 Oct ;67(10):1448-56. Epub 2015 Jul 21. PMID:
26206395
Article Published Date
: Sep 30, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Propolis: Brazillian
Diseases
:
Lung Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Bromelain has anti-tumor initiating activity against skin cancer cells.
Sep 18, 2009
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2009 Sep 18;282(2):167-76. Epub 2009 Mar 31. PMID:
19339108
Article Published Date
: Sep 18, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Bromelain
Diseases
:
Skin Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Bromelain may have anti-skin tumor activity.
Jan 01, 2008
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2008 Jan 1;226(1):30-7. Epub 2007 Aug 23. PMID:
17889918
Article Published Date
: Jan 01, 2008
Study Type
: In Vitro Study
Additional Links
Substances
:
Bromelain
Diseases
:
Skin Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
C. gigantea extract may be a significant agent for treatment of lung cancer.
Jan 27, 2016
Click here to read the entire abstract
Pubmed Data
: Cytotechnology. 2016 Jan 28. Epub 2016 Jan 28. PMID:
26820971
Article Published Date
: Jan 27, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Mushrooms: All
Diseases
:
Carcinoma: Non-Small-Cell Lung
Pharmacological Actions
:
Antiproliferative
,
Bcl-2 protein down-regulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Cactus polysaccharides have anti-tumor activity on lung squamous carcinoma cells.
Dec 31, 2013
Click here to read the entire abstract
Pubmed Data
: Afr J Tradit Complement Altern Med. 2014 ;11(5):99-104. Epub 2014 Aug 23. PMID:
25395712
Article Published Date
: Dec 31, 2013
Study Type
: In Vitro Study
Additional Links
Substances
:
Prickly Pear Cactus
Diseases
:
Carcinoma: Non-Small-Cell Lung
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
Caffeic acid phenethyl ester inhibits ubiquitination and degradation of p53 and blocks cervical cancer cell growth.
Aug 28, 2022
Click here to read the entire abstract
Pubmed Data
: Curr Mol Med. 2022 Aug 29. Epub 2022 Aug 29. PMID:
36043765
Article Published Date
: Aug 28, 2022
Study Type
: In Vitro Study
Additional Links
Substances
:
Caffeic acid phenethyl ester
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Antiproliferative
,
Tumor Suppressor Protein p53 Upregulation
[+]
Cannabidiol and Cannabis Sativa as a potential treatment in vitro prostate cancer cells.
Apr 30, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Biol Rep. 2023 May ;50(5):4039-4047. Epub 2023 Feb 28. PMID:
36853473
Article Published Date
: Apr 30, 2023
Study Type
: In Vitro Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
Capsaicin inhibits the development of mice lung carcinogenesis through its ability to induce apoptosis.
Sep 30, 2013
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2013 Oct ;17(2):254-9. Epub 2013 Jun 6. PMID:
23747734
Article Published Date
: Sep 30, 2013
Study Type
: In Vitro Study
Additional Links
Substances
:
Capsaicin
Diseases
:
Benzo[a]pyrene-induced Toxicity
,
Lung Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Carnosic acid enhances sensitization against TRAIL-mediated apoptosis through the down-regulation of c-FLIP and Bcl-2 expression.
Jan 29, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2015 Jan 30 ;6(3):1556-68. PMID:
25596735
Article Published Date
: Jan 29, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Carnosic Acid
Diseases
:
Breast Cancer: Triple Negative
,
Kidney Cancer
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Chemosensitizer
,
Tumor Suppressor Protein p53 Upregulation
[+]
Carnosic acid induced apoptosis in HCT116 cells via generation of ROS, induction of p53, activation of caspases, and inhibition of STAT3 signaling pathway.
Jul 07, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Carcinog. 2015 Jul 8. Epub 2015 Jul 8. PMID:
26152521
Article Published Date
: Jul 07, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Carnosic Acid
,
Rosemary
Diseases
:
Colon Cancer
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Caspase-3 Activation
,
Caspase-9 Activation
,
STAT3 Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Carnosol induces apoptosis in human colon cancer HCT116 cells.
Mar 31, 2014
Click here to read the entire abstract
Pubmed Data
: Int J Oncol. 2014 Apr ;44(4):1309-15. Epub 2014 Jan 27. PMID:
24481553
Article Published Date
: Mar 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Carnosol
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
STAT3 Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Carnosol led to p53 reactivation in the U87MG human glioblastoma cell line.
Apr 30, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Biochem Cell Biol. 2016 May ;74:95-108. Epub 2016 Mar 3. PMID:
26939786
Article Published Date
: Apr 30, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Carnosol
Diseases
:
Glioblastoma
Pharmacological Actions
:
Antineoplastic Agents
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Chemotherapeutic Synergy: Temozolomide
,
Reactivation Of Tumor Suppressor Gene
[+]
Cell cycle kinetics, apoptosis rates, DNA damage and TP53 gene expression in bladder cancer cells treated with allyl isothiocyanate.
Mar 31, 2014
Click here to read the entire abstract
Pubmed Data
: Mutat Res. 2014 Apr ;762:40-6. Epub 2014 Mar 10. PMID:
24625788
Article Published Date
: Mar 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Isothiocyanates
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Chloroform extract of Citrus unshiu Markovich peel induces apoptosis and inhibits stemness in HeLa human cervical cancer cells.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2021 Jan ;23(1):1. Epub 2020 Nov 25. PMID:
33236129
Article Published Date
: Dec 31, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Orange: Mandarin
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Apoptotic
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Chrysin and Capsaicin induces premature senescence and apoptosis via mitochondrial dysfunction and p53 elevation in Cervical cancer cells.
Apr 30, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Saudi J Biol Sci. 2022 May ;29(5):3838-3847. Epub 2022 Mar 9. PMID:
35844432
Article Published Date
: Apr 30, 2022
Study Type
: In Vitro Study
Additional Links
Substances
:
Capsaicin
,
Chrysin
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Cell cycle arrest
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Chrysin may be a potential candidate agent for the induction of cell apoptosis in human HCC.
Jun 30, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2016 Jul ;12(1):469-474. Epub 2016 Apr 20. PMID:
27347080
Article Published Date
: Jun 30, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Chrysin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Combination therapy with sulindac and vitamin C could be a novel anti-cancer therapeutic strategy for p53 wild type colon cancers.
Jun 19, 2016
Click here to read the entire abstract
Pubmed Data
: Toxicol Lett. 2016 Jun 20. Epub 2016 Jun 20. PMID:
27339904
Article Published Date
: Jun 19, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Colon Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Combined Effects of Tanshinone IIA and an autophagy inhibitor on the apoptosis of leukemia cells.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Integr Cancer Ther. 2022 Jan-Dec;21:15347354221117776. PMID:
35996358
Article Published Date
: Dec 31, 2021
Study Type
: In Vitro Study
Additional Links
Substances
:
Tanshinone IIA
Diseases
:
Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Combined use of lower concentrations of jerantinine A and γ-tocotrienol induced potent cytotoxic effects on U87MG cancer cells.
Jun 30, 2017
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2017 Jul 1 ;30:74-84. Epub 2017 Mar 10. PMID:
28545672
Article Published Date
: Jun 30, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin E: Gamma-tocotrienol
Diseases
:
Glioblastoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemoprotective Agents
,
Chemosensitizer
,
Chemotherapeutic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Glioblastoma
,
Natural Substance/Drug Synergy
,
Vitamin E: Gamma-tocotrienol
[+]
Comparison of the effects of resveratrol and its derivatives on the radiation response of MCF-7 breast cancer cells.
Aug 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2021 Sep 1 ;22(17). Epub 2021 Sep 1. PMID:
34502426
Article Published Date
: Aug 31, 2021
Study Type
: In Vitro Study
Additional Links
Substances
:
Resveratrol
Diseases
:
Breast Cancer
Pharmacological Actions
:
Apoptotic
,
Radiosensitizer
,
Tumor Suppressor Protein p53 Upregulation
[+]
Comparisons of the anti-tumor activity of polysaccharides from fermented mycelia and cultivated fruiting bodies of Cordyceps militaris in vitro.
May 31, 2019
Click here to read the entire abstract
Pubmed Data
: Int J Biol Macromol. 2019 Jun 1 ;130:307-314. Epub 2019 Feb 27. PMID:
30825564
Article Published Date
: May 31, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Cordyceps Militaris
Diseases
:
Non-Small-Cell Lung Carcinoma
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Condurango 30C appeared to trigger key epigenetic events of gene modulation in effectively combating cancer cells, which the placebo was unable to do.
Nov 30, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Pharmacopuncture. 2013 Dec ;16(4):7-13. PMID:
25780677
Article Published Date
: Nov 30, 2013
Study Type
: In Vitro Study
Additional Links
Substances
:
Homeopathic Medicine: All
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Histone deacetylase inhibitor
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Epigenetic Modification In Cancer
,
Homeopathic Vs. Conventional Treatment
,
Low-Dose Pharmacology
[+]
Crocetin combined with cisplatin exerts a synergistic anticancer effect by up-regulating the p53/p21 pathway.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Cell Int. 2017 ;17:98. Epub 2017 Oct 30. PMID:
29093644
Article Published Date
: Dec 31, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Crocetin
Diseases
:
Esophageal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemosensitizer
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Chemotherapeutic Synergy: Cisplatin
[+]
Crocin can significantly inhibit the growth of HO-8910 cells and arrest them in the G0/G1 phase.
Jan 31, 2015
Click here to read the entire abstract
Pubmed Data
: Nat Prod Commun. 2015 Feb ;10(2):249-52. PMID:
25920253
Article Published Date
: Jan 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Crocin
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Caspase-3 Activation
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Cucurbitacin B may exert a therapeutic effect on paclitaxel-resistant human ovarian cancer.
Jun 30, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2017 Jul ;14(1):145-152. Epub 2017 May 10. PMID:
28693146
Article Published Date
: Jun 30, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Cucurbitacin B
Diseases
:
Cancers: Drug Resistant
,
Ovarian Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Cucurbitacin B might be a promising tratrment for cholangiocarcinoma treatment by targeting FAK protein.
Dec 31, 2019
Click here to read the entire abstract
Pubmed Data
: Am J Chin Med. 2020 ;48(6):1475-1489. Epub 2020 Sep 9. PMID:
32907364
Article Published Date
: Dec 31, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Cucurbitacin B
Diseases
:
Cholangiocarcinoma
Pharmacological Actions
:
Antiproliferative
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin and Ellagic acid show anti-HPV activity as evidenced by decrease in the HPV E6 oncoprotein on HeLa cells.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2016 Jul ;81:31-7. Epub 2016 Apr 8. PMID:
27261574
Article Published Date
: Jun 30, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
,
Ellagic Acid
Diseases
:
Cervical Cancer
,
Human Papillomavirus (HPV)
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
E6 Oncoprotein
,
Natural Substance Synergy
[+]
Curcumin and resveratrol programmed cell death in human neuroblastoma.
Mar 01, 2004
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2004 Mar-Apr;24(2B):987-98. PMID:
15161054
Article Published Date
: Mar 01, 2004
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
,
Resveratrol
Diseases
:
Neuroblastoma
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Stilbenes
[+]
Curcumin compares favorably with oxaliplatin as an antiproliferative in colorectal cell lines.
Jul 01, 2007
Click here to read the entire abstract
Pubmed Data
: Int J Cancer. 2007 Jul 1;121(1):175-83. PMID:
17330230
Article Published Date
: Jul 01, 2007
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Drug: Oxaliplatin
,
Natural Substances Versus Drugs
[+]
Curcumin could be used as a novel and effective approach for the treatment of melanoma.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Mol Biol Rep. 2015 Jan ;42(1):267-75. Epub 2014 Sep 28. PMID:
25262359
Article Published Date
: Dec 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Melanoma
,
Skin Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dose Response
[+]
Curcumin exhibits anti-angiogenic properties.
Aug 01, 2002
Click here to read the entire abstract
Pubmed Data
: Int J Oncol. 2002 Aug;21(2):379-83. PMID:
12118335
Article Published Date
: Aug 01, 2002
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Pharmacological Actions
:
Anti-Angiogenic
,
Antineoplastic Agents
,
Antiproliferative
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin exhibits anti-cancer activity against highly metastatic melanoma cells.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: Mol Pharmacol. 2009 Dec;76(6):1238-45. Epub 2009 Sep 24. PMID:
19779032
Article Published Date
: Dec 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Cancer Metastasis
,
Melanoma
Pharmacological Actions
:
Anti-metastatic
,
Antineoplastic Agents
,
PRL-3 Down-Regulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin has anti-cancer activity against gllioblastoma cells.
Oct 17, 2008
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2008 Oct 17;375(2):275-9. Epub 2008 Aug 13. PMID:
20596601
Article Published Date
: Oct 17, 2008
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Glioblastoma
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin has anti-glioma properties.
Dec 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Neurooncol. 2007 Dec;85(3):263-70. Epub 2007 Jun 27. PMID:
17594054
Article Published Date
: Dec 01, 2007
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin has anticancer activity on human Burkitt's lymphoma cells.
Jul 01, 2002
Click here to read the entire abstract
Pubmed Data
: Zhonghua Zhong Liu Za Zhi. 2002 Jul;24(4):348-52. PMID:
12408761
Article Published Date
: Jul 01, 2002
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Burkitt Lymphoma
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin has chemopreventive properties in nicotine-induced proliferation and angiogenesis in llung cancer cells.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Mol Cancer. 2010;9:220. Epub 2010 Aug 20. PMID:
20727180
Article Published Date
: Jan 01, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Lung Cancer
,
Nicotine/Tobacco Toxicity
Pharmacological Actions
:
Anti-Angiogenic
,
Antiproliferative
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin has the ability to improve the paclitaxel induced apoptosis of HPV positive human cervical cancer cell lines via the NF-κB-p53-caspase-3 pathway.
Mar 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2015 Apr ;9(4):1470-1476. Epub 2015 Jan 29. PMID:
25780454
Article Published Date
: Mar 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Apoptotic
,
Caspase-3 Activation
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Chemothapeutic Synergy: Paclitaxel
[+]
Curcumin induced cell death in HeLa cells via induction of DNA damage, and chromatin condensation in vitro.
Aug 03, 2016
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2016 Aug 4. Epub 2016 Aug 4. PMID:
27499229
Article Published Date
: Aug 03, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin induces heat shock protein and inhibits p53 gene expression in colorectal cancer cells.
May 01, 2005
Click here to read the entire abstract
Pubmed Data
: Pediatrics. 2005 May;115(5):1360-6. PMID:
8989916
Article Published Date
: May 01, 2005
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Apoptotic
,
Calcium Channel Blockers
,
Cell cycle arrest
,
Heat Shock Protein Inducer
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin induces programmed cell death in breast cancer.
Feb 13, 2002
Click here to read the entire abstract
Pubmed Data
: FEBS Lett. 2002 Feb 13;512(1-3):334-40. PMID:
11852106
Article Published Date
: Feb 13, 2002
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Breast Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin induces programmed cell death in human colon cancer cells.
Nov 01, 2010
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2010 Nov 1;297(1):1-8. Epub 2010 May 15. PMID:
20472336
Article Published Date
: Nov 01, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colon Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin induces programmed cell death in human colon cancer cells.
May 01, 2010
Click here to read the entire abstract
Pubmed Data
: J Oral Maxillofac Surg. 2010 May;68(5):1158-61. PMID:
16302093
Article Published Date
: May 01, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin induces programmed cell death in human liver cancer cells.
Aug 01, 1996
Click here to read the entire abstract
Pubmed Data
: Oncogene. 1996 Aug 1;13(3):609-16. PMID:
8760302
Article Published Date
: Aug 01, 1996
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin induces programmed cell death in human melanoma cells.
Dec 10, 2001
Click here to read the entire abstract
Pubmed Data
: Exp Cell Res. 2001 Dec 10;271(2):305-14. PMID:
11716543
Article Published Date
: Dec 10, 2001
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Cancers: Drug Resistant
,
Melanoma
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Chemosensitizer
,
Enzyme Inhibitors
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin inhibits invasive ductal carcinoma of the breast in the cell model.
Feb 12, 2010
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2010 Feb 12;183(3):455-61. Epub 2009 Nov 26. PMID:
19944674
Article Published Date
: Feb 12, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Breast Cancer
,
Ductal Carcinoma: Invasive
Pharmacological Actions
:
Anti-Proliferative
,
Antineoplastic Agents
,
Maspin (Protease Inhibitor) Up-Regulation
,
Protease Inhibitors
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin inhibits melanoma proliferation by arresting growth and induces programmed cell death.
Jun 01, 2004
Click here to read the entire abstract
Pubmed Data
: Melanoma Res. 2004 Jun;14(3):165-71. PMID:
15179184
Article Published Date
: Jun 01, 2004
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Melanoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin inhibits programmed cell death in breast cancer cells.
May 20, 2005
Click here to read the entire abstract
Pubmed Data
: J Biol Chem. 2005 May 20;280(20):20059-68. Epub 2005 Feb 28. PMID:
15738001
Article Published Date
: May 20, 2005
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin inhibits the growth and induces programmed cell death in B cell lymphoma cells.
Nov 01, 1999
Click here to read the entire abstract
Pubmed Data
: Clin Immunol. 1999 Nov;93(2):152-61. PMID:
10527691
Article Published Date
: Nov 01, 1999
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Lymphoma: B-Cell
Pharmacological Actions
:
Apoptotic
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells.
Aug 15, 2006
Click here to read the entire abstract
Pubmed Data
: Int J Cancer. 2006 Aug 15;119(4):757-64. PMID:
16550606
Article Published Date
: Aug 15, 2006
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Cancers: All
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin is a multi-targeting agent, simultaneously activating the tumor suppressor p53/p73 pathways and inhibiting pro-apoptotic p-AKT and Bcl-2 levels.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(4):e0124218. Epub 2015 Apr 24. PMID:
25910231
Article Published Date
: Dec 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Carcinoma: Non-Small-Cell Lung
,
Head and Neck Cancer
,
Head and Neck Neoplasms
,
Lung Cancer
,
Lung Cancer: Metastatic
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin may be considered a novel therapeutic strategy to inhibit gastric cancer cell growth.
Nov 30, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2016 Dec ;12(6):5156-5162. Epub 2016 Nov 4. PMID:
28105222
Article Published Date
: Nov 30, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Antiproliferative
,
Bax/Bcl2 ratio: Increase
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Antiproliferative
,
CURCUMIN
,
gastric cancer
[+]
Curcumin may be useful to prevent changes of atherosclerosis and post-angioplasty restenosis.
Jul 01, 1998
Click here to read the entire abstract
Pubmed Data
: Br J Pharmacol. 1998 Jul;124(6):1029-40. PMID:
9720770
Article Published Date
: Jul 01, 1998
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Angioplasty
,
Atherosclerosis
,
Restenosis
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Protein Kinase Inhibitors
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin may have therapeutic value in HIV infection.
Feb 19, 2010
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2010 Feb 19. Epub 2010 Feb 19. PMID:
15383533
Article Published Date
: Feb 19, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
HIV Infections
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Enzyme Inhibitors
,
Histone deacetylase inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin nanoencapsulation with whey protein had enhanced colon cancer chemoprevention effects.
Jul 08, 2016
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2016 Jul 9. Epub 2016 Jul 9. PMID:
27404761
Article Published Date
: Jul 08, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
,
Whey
Diseases
:
Colon Cancer
Pharmacological Actions
:
Bax/Bcl2 ratio: Increase
,
Chemopreventive
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin suppresses growth and chemoresistance of human glioblastoma cells.
Jul 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Neurochem. 2007 Jul;102(2):522-38. PMID:
17596214
Article Published Date
: Jul 01, 2007
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Cancers: Drug Resistant
,
Glioblastoma
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin suppresses HPV oncoproteins and HPV upregulation associated wtih benzo[a]pyrene exposure.
Jan 01, 2011
Click here to read the entire abstract
Pubmed Data
: Mol Carcinog. 2011 Jan;50(1):47-57. PMID:
21061268
Article Published Date
: Jan 01, 2011
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Cervical Cancer
,
Human Papillomavirus (HPV)
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Chemopreventive
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin synergizes with resveratrol to inhibit colon cancer.
Jan 01, 2003
Click here to read the entire abstract
Pubmed Data
: J Endocrinol. 2003 Jan;176(1):163-8. PMID:
19838927
Article Published Date
: Jan 01, 2003
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
,
Resveratrol
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Natural Substance Synergy
,
Stilbenes
[+]
Curcumin targets numerous therapeutically important cancer signalling pathways.
Jul 27, 2016
Click here to read the entire abstract
Pubmed Data
: Tumour Biol. 2016 Jul 28. Epub 2016 Jul 28. PMID:
27468716
Article Published Date
: Jul 27, 2016
Study Type
: Review
Additional Links
Substances
:
Curcumin
Diseases
:
Cancers: All
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
,
Wnt/β-catenin pathway down-regulation
Additional Keywords
:
Tumor Microenvironment
[+]
Curcumin work synergistically with a PI3K inhibitor to induce cell death in breast cancer cellis.
Apr 09, 2010
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2010 Apr 9;394(3):476-81. Epub 2010 Feb 6. PMID:
20138829
Article Published Date
: Apr 09, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Drug Synergy
[+]
Curcumin-induced cell death of ovarian carcinoma has a known mechnism.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Mol Carcinog. 2010 Jan;49(1):13-24. PMID:
19676105
Article Published Date
: Jan 01, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Cyanidin-3-glucoside had an apoptogenic effect in the glioblastoma multiforme cell line.
Nov 30, 2017
Click here to read the entire abstract
Pubmed Data
: World Neurosurg. 2017 Dec ;108:94-100. Epub 2017 Sep 1. PMID:
28867321
Article Published Date
: Nov 30, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Cyanidin 3-glucoside
Diseases
:
Glioblastoma Multiforme
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Cytotoxic activity of caffeic acid and gallic acid against MCF-7 human breast cancer cells.
Oct 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Avicenna J Phytomed. 2019 Nov-Dec;9(6):574-586. PMID:
31763216
Article Published Date
: Oct 31, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Caffeic Acid
,
Gallic Acid
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Cytotoxicity of citral against melanoma cells.
Feb 28, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Tumour Biol. 2017 Mar ;39(3):1010428317695914. PMID:
28351318
Article Published Date
: Feb 28, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Citral
Diseases
:
Melanoma
,
Oxidative Stress
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
D-limonene exerts its cytotoxic effect on BGC-823 gastric cancer cells by inducing apoptosis.
Jun 30, 2003
Click here to read the entire abstract
Pubmed Data
: Zhonghua Zhong Liu Za Zhi. 2003 Jul ;25(4):325-7. PMID:
12921557
Article Published Date
: Jun 30, 2003
Study Type
: In Vitro Study
Additional Links
Substances
:
D-Limonene
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
D. burmannii is a promising source of potential anti-inflammatory agents and may be useful as an anticancer agent against breast carcinoma.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Death Discov. 2016 ;2:15062. Epub 2016 Jan 18. PMID:
27551490
Article Published Date
: Dec 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Homeopathic Medicine: All
Diseases
:
Breast Cancer
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells.
Apr 30, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2014 May ;7(5):1479-1484. Epub 2014 Feb 20. PMID:
24765160
Article Published Date
: Apr 30, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Damnacanthal
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Data support the potential for using the agent thymoquinone for the treatment of colon cancer.
Sep 30, 2004
Click here to read the entire abstract
Pubmed Data
: Int J Oncol. 2004 Oct ;25(4):857-66. PMID:
15375533
Article Published Date
: Sep 30, 2004
Study Type
: In Vitro Study
Additional Links
Substances
:
Thymoquinone
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Deguelin potentiates apoptosis and induces differentiation in AML cells carrying the NPM1 mutation.
Jan 31, 2015
Click here to read the entire abstract
Pubmed Data
: Ann Hematol. 2015 Feb ;94(2):201-10. Epub 2014 Sep 23. PMID:
25242579
Article Published Date
: Jan 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Deguelin
Diseases
:
Acute Myeloid Leukemia
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Delphinidin may be useful in the prevention of prostate cancer.
Aug 29, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 Aug 30 ;7(35):56767-56780. PMID:
27462923
Article Published Date
: Aug 29, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Delphinidin
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Epigenetic Modification In Cancer
,
Plant Extracts
[+]
Delta 9-tetrahydrocannabinol exhibits anti-tumor properties.
Jun 14, 2007
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2007 Jun 14;564(1-3):57-65. Epub 2007 Feb 22. PMID:
17379209
Article Published Date
: Jun 14, 2007
Study Type
: In Vitro Study
Additional Links
Substances
:
Delta-tetrahydrocannabinol (THC)
Diseases
:
Tumors
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Demethoxycurcumin induced DNA damage and affected DNA repair proteins in NCI-H460 cells in vitro.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2015 May ;35(5):2691-8. PMID:
25964547
Article Published Date
: Apr 30, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Demethoxycurcumin
Diseases
:
Lung Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
DHA may be more effective than EPA in growth suppression of TOV-21G cells.
Mar 03, 2016
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2016 Mar 4:1-8. Epub 2016 Mar 4. PMID:
26942868
Article Published Date
: Mar 03, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Docosahexaenoic acid (DHA)
,
EPA (Eicosapentaenoic Acid)
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Antiproliferative
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dose Response
[+]
Diallyl disulfide (DADS), a major organosulfur compound of garlic oil, is capable of inhibiting colon cancer cells.
Jan 01, 2008
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2008 Jan;19(1):275-80. PMID:
18097607
Article Published Date
: Jan 01, 2008
Study Type
: In Vitro Study
Additional Links
Substances
:
Garlic
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Tumor Suppressor Protein p53 Upregulation
[+]
Diallyl sulfide significantly inhibits the growth and induces apoptosis of human cervical cancer HeLa cells in vitro.
May 31, 2011
Click here to read the entire abstract
Pubmed Data
: Int J Oncol. 2011 Jun ;38(6):1605-13. Epub 2011 Mar 17. PMID:
21424116
Article Published Date
: May 31, 2011
Study Type
: In Vitro Study
Additional Links
Substances
:
Diallyl sulfide
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Antioxidants
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dose Response
[+]
Dietary flavonoid carvacrol triggers the apoptosis of human breast cancer MCF-7 cells via the p53/Bax/Bcl-2 axis.
Dec 09, 2022
Click here to read the entire abstract
Pubmed Data
: Med Oncol. 2022 Dec 10 ;40(1):46. Epub 2022 Dec 10. PMID:
36495389
Article Published Date
: Dec 09, 2022
Study Type
: In Vitro Study
Additional Links
Substances
:
Carvacrol
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Diosmetin induces cell apoptosis by regulating CYP1A1/CYP1A2 due to p53 activation in HepG2 cells.
May 09, 2017
Click here to read the entire abstract
Pubmed Data
: Protein Pept Lett. 2017 May 10 ;24(5):406-412. PMID:
28245756
Article Published Date
: May 09, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Diosmetin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity.
Jan 03, 2017
Click here to read the entire abstract
Pubmed Data
: Toxicol Lett. 2017 Jan 4 ;265:117-130. Epub 2016 Nov 24. PMID:
27890807
Article Published Date
: Jan 03, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Diosmin
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Autophagy Up-regulation
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
ECMS might be a promising candidate for the therapy of the non-small cell lung cancer by regulating multiple molecular targets.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Am J Chin Med. 2015 ;43(1):149-66. Epub 2015 Feb 4. PMID:
25649746
Article Published Date
: Dec 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Gac
Diseases
:
Carcinoma: Non-Small-Cell Lung
,
Lung Cancer
,
Lung Cancer: Metastatic
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
STAT3 Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Effects of bergamot essential oil and its extractive fractions on SH-SY5Y human neuroblastoma cell growth.
Jul 31, 2015
Click here to read the entire abstract
Pubmed Data
: J Pharm Pharmacol. 2015 Aug ;67(8):1042-53. Epub 2015 Mar 24. PMID:
25808679
Article Published Date
: Jul 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Bergamot
Diseases
:
Neuroblastoma
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Essential Oils
[+]
Effects of D-limonene on leukemia cells HL-60 and K562 in vitro
Jul 31, 2006
Click here to read the entire abstract
Pubmed Data
: Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Aug ;14(4):692-5. PMID:
16928301
Article Published Date
: Jul 31, 2006
Study Type
: In Vitro Study
Additional Links
Substances
:
D-Limonene
Diseases
:
Leukemia: Chronic myelogenous leukemia (CML)
,
Promyelocytic leukemia
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Effects of genistein on anti-tumor activity of cisplatin in human cervical cancer cell lines.
Aug 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Obstet Gynecol Sci. 2019 Sep ;62(5):322-328. Epub 2019 Aug 6. PMID:
31538075
Article Published Date
: Aug 31, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Genistein
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Chemotherapeutic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Chemotherapeutic Synergy: Cisplatin
[+]
EGCG is a potent apoptosis inducer that functions exclusively through a p53-dependent pathway in A549 cells.
Jul 31, 2009
Click here to read the entire abstract
Pubmed Data
: Toxicol In Vitro. 2009 Aug ;23(5):834-9. Epub 2009 May 3. PMID:
19406223
Article Published Date
: Jul 31, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
,
Epicatechin
Diseases
:
Lung Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Ellagic acid and human cancers: a systems pharmacology and docking study.
May 13, 2020
Click here to read the entire abstract
Pubmed Data
: Mol Divers. 2020 May 14. Epub 2020 May 14. PMID:
32410114
Article Published Date
: May 13, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Ellagic Acid
Diseases
:
Breast Cancer
,
Cancers: All
,
Cervical Cancer
,
Colorectal Cancer
,
Liver Cancer
,
Pancreatic Cancer
,
Prostate Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
,
Wnt/β-catenin signaling pathway modulation
Additional Keywords
:
Gene Expression Regulation
[+]
Ellagic acid induces apoptosis in TSGH8301 human bladder cancer cells.
Oct 31, 2014
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol. 2014 Nov ;29(11):1262-74. Epub 2013 Mar 30. PMID:
23554011
Article Published Date
: Oct 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Ellagic Acid
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Cell cycle arrest
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Epigallocatechin gallate induces CHD5 gene demethylation to promote acute myeloid leukemia cell apoptosis.
Sep 29, 2020
Click here to read the entire abstract
Pubmed Data
: Nan Fang Yi Ke Da Xue Xue Bao. 2020 Sep 30 ;40(9):1230-1238. PMID:
32990229
Article Published Date
: Sep 29, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Epigallocatechin gallate, folic acid, vitamin B12, and hyaluronic acid significantly increase apoptosis and p53 expression in HeLa cells.
May 31, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Eur Rev Med Pharmacol Sci. 2023 Jun ;27(11):5240-5245. PMID:
37318498
Article Published Date
: May 31, 2023
Study Type
: In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Folate
,
Vitamin B-12
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Fenugreek induced apoptosis in hepatocellular carcinoma cell line HepG2.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2015;2015:914645. Epub 2015 Oct 18. PMID:
26557712
Article Published Date
: Dec 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Fenugreek
Diseases
:
Liver Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Feverfew contains the compound parthenolide which induces cell death in acute myelogenous leukaemia (AML), in vitro - Article 2.
Jun 01, 2005
Click here to read the entire abstract
Pubmed Data
: Blood. 2005 Jun 1;105(11):4163-9. Epub 2005 Feb 1. PMID:
15687234
Article Published Date
: Jun 01, 2005
Study Type
: In Vitro Study
Additional Links
Substances
:
Feverfew
Diseases
:
Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Feverfew contains the compound parthenolide which selectively eradicates acute myelogenous leukemia stem and progenitor cells.
Dec 15, 2007
Click here to read the entire abstract
Pubmed Data
: Blood. 2007 Dec 15;110(13):4427-35. Epub 2007 Sep 5. PMID:
17804695
Article Published Date
: Dec 15, 2007
Study Type
: In Vitro Study
Additional Links
Substances
:
Feverfew
Diseases
:
Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions
:
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Selective Cytotoxicity
[+]
Fisetin contributes to inducing programmed cell death in colon cancer cells.
May 01, 2009
Click here to read the entire abstract
Pubmed Data
: Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1060-8. Epub 2009 Mar 5. PMID:
19264955
Article Published Date
: May 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Fisetin
,
Flavonoids
Diseases
:
Colon Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Fisetin induces apoptosis through p53-mediated up-regulation of DR5 expression in human renal carcinoma caki cells.
Aug 01, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2017 Aug 2 ;22(8). Epub 2017 Aug 2. PMID:
28767099
Article Published Date
: Aug 01, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Fisetin
Diseases
:
Kidney Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Flavonoids from Gynostemma pentaphyllum exhibit differential induction of cell cycle arrest in H460 and A549 cancer cells.
Oct 30, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2014 Oct 31 ;19(11):17663-81. Epub 2014 Oct 31. PMID:
25365293
Article Published Date
: Oct 30, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Flavonoids
,
Gynostemma
Diseases
:
Carcinoma: Non-Small-Cell Lung
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
Fucoidan induces apoptosis of HepG2 cells by down-regulating p-Stat3.
May 31, 2014
Click here to read the entire abstract
Pubmed Data
: J Huazhong Univ Sci Technolog Med Sci. 2014 Jun ;34(3):330-336. Epub 2014 Jun 18. PMID:
24939294
Article Published Date
: May 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Fucoidan
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Fucoidan triggered G1 arrest and apoptosis in HCT116 cells by a p53-independent mechanism.
May 29, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mar Drugs. 2017 May 30 ;15(6). Epub 2017 May 30. PMID:
28555064
Article Published Date
: May 29, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Fucoidan
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Galangin induced apoptosis via p53-dependent pathway in ovarian cells.
Mar 29, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2020 Mar 30 ;25(7). Epub 2020 Mar 30. PMID:
32235536
Article Published Date
: Mar 29, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Galangin induces autophagy through upregulation of p53 in HepG2 cells.
Dec 31, 2011
Click here to read the entire abstract
Pubmed Data
: Pharmacology. 2012 ;89(5-6):247-55. PMID:
22507894
Article Published Date
: Dec 31, 2011
Study Type
: In Vitro Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Liver Cancer
Pharmacological Actions
:
Apoptotic
,
Autophagy Inhibitors
,
Tumor Suppressor Protein p53 Upregulation
[+]
Galangin induces p53-independent S-phase arrest and apoptosis in human nasopharyngeal carcinoma cells.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2018 03 ;38(3):1377-1389. PMID:
29491062
Article Published Date
: Dec 31, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Nasopharyngeal Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Gallic acid could be a potential candidate for the development of anti-HPV agents.
Jun 08, 2015
Click here to read the entire abstract
Pubmed Data
: J Med Virol. 2015 Jun 9. Epub 2015 Jun 9. PMID:
26059022
Article Published Date
: Jun 08, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Gallic Acid
Diseases
:
Cervical Cancer
,
Human Papillomavirus (HPV)
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Selective Cytotoxicity
[+]
Gamma tocotrienol promotes programmed cell death in cancer cell lines.
Aug 01, 2010
Click here to read the entire abstract
Pubmed Data
: Mol Cancer Ther. 2010 Aug;9(8):2196-207. Epub 2010 Aug 3. PMID:
20682650
Article Published Date
: Aug 01, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Tocotrienol: Gamma
Diseases
:
Colon Cancer
,
Kidney Cancer
,
Pancreatic Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Ganoderic acid A and its amide derivatives as potential anti-cancer agents.
Mar 03, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2023 Mar 4 ;28(5). Epub 2023 Mar 4. PMID:
36903622
Article Published Date
: Mar 03, 2023
Study Type
: In Vitro Study
Additional Links
Substances
:
Reishi Mushroom
Diseases
:
Cancers: All
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Ganoderma lucidum polysaccharides show prominent anticancer activities by reactivating several types of mutant p53.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2017 Jan ;37(1):594-600. Epub 2016 Nov 15. PMID:
27878254
Article Published Date
: Dec 31, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Reishi Mushroom
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Chemotherapeutic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Chemothapeutic Synergy: 5-flourouracil
,
Polysaccharides
,
Reactivation Of Tumor Suppressor Gene
[+]
Garlic, particularly water extracts, have inhibitory properties against liver cancer cells.
Nov 01, 2006
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2006 Nov ;17(11):742-9. Epub 2006 Jan 24. PMID:
16520031
Article Published Date
: Nov 01, 2006
Study Type
: In Vitro Study
Additional Links
Substances
:
Garlic
Diseases
:
Liver Cancer
Pharmacological Actions
:
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Location Specific Therapeutic Property
,
Plant Extracts
[+]
Gastrodin is a new potential agent for the treatment of human glioblastoma .
Aug 31, 2017
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2017 Sep ;107(Pt A):280-292. Epub 2017 Jul 6. PMID:
28689919
Article Published Date
: Aug 31, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Gastrodin
Diseases
:
Glioblastoma
,
Oxidative Stress
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
,
Selective Cytotoxicity
[+]
Genipin may be used as a novel therapeutic agent in the treatment of colon cancer .
Aug 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2018 Sep ;16(3):2957-2964. Epub 2018 Jun 26. PMID:
30127884
Article Published Date
: Aug 31, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Genipin
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Genistein suppresses the proliferative activity in Src-activated human gallbladder carcinoma cells.
Jul 23, 2020
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2020 Jul 24:1-9. Epub 2020 Jul 24. PMID:
32705888
Article Published Date
: Jul 23, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Genistein
Diseases
:
Gallbladder Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis.
Jan 10, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Death Dis. 2016 08 11 ;7(8):e2334. Epub 2016 Aug 11. PMID:
27512955
Article Published Date
: Jan 10, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Cancers: Drug Resistant
,
Colon Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Ginsenoside Rg3 inhibits the biological activity of SGC-7901.
Jul 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Food Sci Nutr. 2020 Aug ;8(8):4151-4158. Epub 2020 Jun 24. PMID:
32884696
Article Published Date
: Jul 31, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Antiproliferative
,
Tumor Suppressor Protein p53 Upregulation
[+]
Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53.
Feb 27, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Lett. 2011 Feb 28 ;301(2):185-92. Epub 2010 Dec 30. PMID:
21194832
Article Published Date
: Feb 27, 2011
Study Type
: In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antioxidants
,
Apoptotic
,
NF-kappaB Inhibitor
,
Paraptosis
,
Tumor Suppressor Protein p53 Upregulation
[+]
Ginsenoside Rh2 induces apoptosis in human neuroblastoma.
Jul 31, 2004
Click here to read the entire abstract
Pubmed Data
: Arch Pharm Res. 2004 Aug ;27(8):834-9. PMID:
15460444
Article Published Date
: Jul 31, 2004
Study Type
: In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Neuroblastoma
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
Ginsenoside Rh2 inhibits proliferation and promotes apoptosis of leukemia KG1-α cells.
May 31, 2014
Click here to read the entire abstract
Pubmed Data
: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Jun ;30(6):565-8. PMID:
24909273
Article Published Date
: May 31, 2014
Study Type
: In Vitro
