Vascular Endothelial Growth Factor Inhibitors

Name	AC	CK
Ginsenosides	18	34
Curcumin	13	23
Resveratrol	4	15
Bilberry	3	13
EGCG (Epigallocatechin gallate)	6	13
Nigella sativa (aka Black Seed)	2	12
Vitamin D	2	12
Cannabinoids	2	11
Thymoquinone	7	11
Delta-tetrahydrocannabinol (THC)	1	10
Tanshinone IIA	10	10
Zataria multiflora	1	10
Melatonin	4	8
Polyphenols	3	8
Anthocyanins	4	7
Apigenin	5	6
Flavonoids	4	6
Vitamin C	5	6
Apple Polyphenols	1	5
Bee Venom	3	5
Black Raspberry	1	5
Ginkgo biloba	3	5
Lactoferrin	4	5
Parthenolide	3	5
Fucoidan	4	4
Genistein	3	4
Gingerol	2	4
Sulforaphane	2	4
Angelica	2	3
Astragaloside	2	3
Berberine	3	3
Beta-Elemene	2	3
Chlorogenic Acid	3	3
Delphinidin	2	3
Honokiol	2	3
Huaier (Trametes robiniophila murr)	2	3
Luteolin	3	3
Palmitoylethanolamide	2	3
Quercetin	2	3
Xanthohumol	2	3
Acai	1	2
Achiote	1	2
Ashwagandha	1	2
Astaxanthin	1	2
Astragalus	1	2
Bamboo	1	2
Banana	1	2
Betaine	1	2
Biochanin A	1	2
Black Pepper	1	2
Black Tea	2	2
Blueberry	2	2
Boswellia	1	2
Broccoli Sprouts	1	2
Burdock	1	2
Camel Milk	1	2
Catechin	1	2
Chlorella (Algae)	1	2
Cinnamon	2	2
Corn: Purple	1	2
Ellagic Acid	1	2
Eriodictyol	1	2
Formononetin	2	2
Fruit Peel	1	2
Fucoxanthin	1	2
Garcinia dulcis	1	2
Garcinia indica	1	2
Geraniol	1	2
Ginger	1	2
Ginseng (Korean)	2	2
Hesperidin	1	2
Ligustrazine	1	2
Lion's Mane (Hericium Erinaceus)	1	2
Liquiritigenin	2	2
Long Pepper	1	2
Lotus	2	2
Lycopene	1	2
MSM (Methylsulfonylmethane)	1	2
Magnolol	1	2
Myricetin	1	2
Nettle	1	2
Nobiletin	1	2
Olive Oil	1	2
Oridonin	1	2
Orthosiphon	1	2
Paeoniflorin	1	2
Palash	1	2
Piceatannol	1	2
Pine Bark Extract	1	2
Pine Needle	1	2
Pomegranate Peel	2	2
Puerarin	2	2
Saccharomyces Boulardii	1	2
Safflower	1	2
Sea buckthorn	1	2
Seaweed	1	2
Shikonin	1	2
Silibinin	1	2
Sophora Flavescens	1	2
Spirulina	1	2
St. Johns Wort	1	2
Syrian rue	2	2
Tetrahydrocurcumin	1	2
Theaflavins	2	2
Thymol	1	2
Tomato	1	2
Triphala	1	2
Turmeric	2	2
Ursolic Acid	2	2
Vitamin B-3 (Niacin)	1	2
Vitexins	1	2
Whey	1	2
White Mulberry	1	2
Barberry	1	1
Benzyl isothiocyanate	1	1
Betulinic acid	1	1
Caffeic acid phenethyl ester	1	1
Cannabidiol	1	1
Carrot	1	1
Celastrol	1	1
Celery	1	1
Chrysin	1	1
Coenzyme Q10	1	1
Crocetin	1	1
Cyanidin 3-glucoside	1	1
D-Limonene	1	1
Dandelion	1	1
Diosgenin	1	1
Fisetin	1	1
Frankincense	1	1
Galbanic Acid	1	1
Grape	1	1
Guggul	1	1
Harmine	1	1
Holy Basil	1	1
Homeopathic Medicine: All	1	1
Hydrangea	1	1
Isoliquiritigenin	1	1
Licorice	1	1
Lychee	1	1
Mulberry	1	1
Oak	1	1
Paeonol	1	1
Peony	1	1
Phloretin	1	1
Phlorotannins	1	1
Piperine	1	1
Proanthocyanidins	1	1
Prunella vulgaris	1	1
Psychedelics:All	1	1
Pterostilbene	1	1
Saffron	1	1
Schisandra	1	1
Silymarin	1	1
Toona sinensis	1	1
Vitamin E	1	1
Wogonin	1	1
Zerumbone	1	1

[+]

Powdered Nigella sativa has potent beneficial effects in improving thyroid status and anthropometric variables.Nov 15, 2016

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Pubmed Data : BMC Complement Altern Med. 2016 Nov 16 ;16(1):471. Epub 2016 Nov 16. PMID: 27852303

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Pubmed Data : Environ Sci Pollut Res Int. 2020 Apr 20. Epub 2020 Apr 20. PMID: 32314290

Article Published Date : Apr 19, 2020

Study Type : Human Study

Additional Links

Substances : Zataria multiflora

Diseases : Chemical Weapon Agent Injury: Sulfur Mustard, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors

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Vitamin D Decreases Serum VEGF Correlating with Clinical Improvement in Vitamin D-Deficient Women with polycystic ovary syndrome.Mar 27, 2017

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Pubmed Data : Chem Biol Interact. 2016 Feb 5 ;245:1-11. Epub 2015 Dec 8. PMID: 26680107

Article Published Date : Feb 04, 2016

Study Type : Animal Study

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Substances : Thymol

Diseases : Diabetic Nephropathy, High Fat Diet

Pharmacological Actions : Renoprotective, Vascular Endothelial Growth Factor Inhibitors

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An aqueous extract of Bixa orellana showed anti-inflammatory properties in serotonin-induced acute inflammation.Dec 31, 2012

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Pubmed Data : Biomed Res Int. 2013 ;2013:463145. Epub 2013 Oct 3. PMID: 24224164

Article Published Date : Dec 31, 2012

Study Type : Animal Study

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Substances : Achiote

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Nitric Oxide Inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Plant Extracts

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Pubmed Data : Environ Toxicol. 2019 Nov 12. Epub 2019 Nov 12. PMID: 31714653

Article Published Date : Nov 11, 2019

Study Type : Animal Study

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Substances : Magnolol

Diseases : Liver Cancer

Pharmacological Actions : Anti-metastatic, Apoptotic, Cyclin D1 Down-Regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors

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Arctigenin prevents retinal edema in a murine retinal vein occlusion model. Dec 31, 2022

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Pubmed Data : Oncotarget. 2015 Jun 8. Epub 2015 Jun 8. PMID: 26116834

Article Published Date : Jun 07, 2015

Study Type : Animal Study, In Vitro Study

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Substances : Curcumin

Diseases : Leukemia: Chronic myelogenous leukemia (CML)

Pharmacological Actions : Antiproliferative , Apoptotic, MicroRNA modulator, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Exosomes

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Delphinidin is a promising compound to prevent pathologies associated with generation of vascular network in tumorigenesis.Dec 31, 2014

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Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug.Jan 31, 2016

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Pubmed Data : Asian Pac J Trop Med. 2016 Feb ;9(2):180-3. Epub 2016 Jan 11. PMID: 26919952

Article Published Date : Jan 31, 2016

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor A Inhibitor, Vascular Endothelial Growth Factor C Inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Natural Substance/Drug Synergy

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Eriodictyol prevents early retinal and plasma abnormalities in streptozotocin-induced diabetic rats.Jun 30, 2012

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Pubmed Data : Biochem Pharmacol. 2012 Jul 1 ;84(1):88-92. Epub 2012 Mar 30. PMID: 22484312

Article Published Date : Jun 30, 2012

Study Type : Animal Study

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Substances : Eriodictyol

Diseases : Diabetic Retinopathy

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors

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Essential oil of Pinus koraiensis leaves has anti-diabetic potential.Dec 31, 2012

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Pubmed Data : Eur J Nutr. 2016 Apr 8. Epub 2016 Apr 8. PMID: 27059477

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Pubmed Data : Mol Nutr Food Res. 2017 04 ;61(4). Epub 2017 Jan 30. PMID: 27921359

Article Published Date : Dec 31, 2016

Study Type : Animal Study

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Substances : Xanthohumol

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Vascular Endothelial Growth Factor Inhibitors

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Morelloflavone is a potential inhibitor of tumor angiogenesis by targeting the Rho GTPase and ERK signaling pathways.Jan 14, 2009

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Pubmed Data : Cancer Res. 2009 Jan 15 ;69(2):518-25. PMID: 19147565

Article Published Date : Jan 14, 2009

Study Type : Animal Study, In Vitro Study

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Substances : Garcinia dulcis

Diseases : Prostate Cancer

Pharmacological Actions : Anti-Angiogenic, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Dose Response

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Musa acuminata lectin protein has promising anticancer potential.Dec 31, 2018

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Pubmed Data : Nutr Cancer. 2019 ;71(2):285-300. Epub 2018 Dec 29. PMID: 30596280

Article Published Date : Dec 31, 2018

Study Type : Animal Study, In Vitro Study

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Substances : Banana

Diseases : Cancers: All, Ehrlich carcinoma

Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Apoptotic, Vascular Endothelial Growth Factor Inhibitors

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Pubmed Data : Exp Parasitol. 2019 Feb ;197:85-92. Epub 2018 Nov 8. PMID: 30414842

Article Published Date : Jan 31, 2019

Study Type : Animal Study

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Substances : Paeoniflorin

Diseases : Liver Disease, Schistosomiasis

Pharmacological Actions : Anti-Angiogenic, Anti-Fibrotic, Vascular Endothelial Growth Factor Inhibitors

[+]

Palmitoylethanolamide may improve inflammation-driven angiogenesis in colonic mucosa.Dec 31, 2015

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Pubmed Data : Sci Rep. 2022 Sep 23 ;12(1):15872. Epub 2022 Sep 23. PMID: 36151457

Article Published Date : Sep 22, 2022

Study Type : Animal Study

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Substances : Silibinin

Diseases : Diabetic Retinopathy

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors

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Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma.Oct 03, 2017

Pubmed Data : Int J Mol Sci. 2016 Dec 9 ;17(12). Epub 2016 Dec 9. PMID: 27941690

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Pubmed Data : Asian Pac J Trop Med. 2017 Apr ;10(4):400-408. Epub 2017 Apr 7. PMID: 28552110

Article Published Date : Mar 31, 2017

Study Type : Animal Study, In Vitro Study

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Substances : Resveratrol, Thymoquinone

Diseases : Breast Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Apoptotic, Immunomodulatory, Interferon-gamma (IFN-gamma) inducer, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Natural Substance Synergy

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Thymoquinone augmented the chemopreventive effect of vitamin D during the initiation phase of colon cancer.Dec 31, 2016

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Pubmed Data : Mol Vis. 2016 ;22:599-609. Epub 2016 Jun 9. PMID: 27293376

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Pubmed Data : Molecules. 2021 Feb 3 ;26(4). Epub 2021 Feb 3. PMID: 33546250

Article Published Date : Feb 02, 2021

Study Type : In Vitro Study

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Substances : Elm tree

Diseases : Cancers: All, Inflammation

Pharmacological Actions : Anti-Angiogenic, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Plant Extracts

[+]

A hydroalcoholic extract of oak acorn shell acts as a potent antiangiogenic agent.Feb 28, 2013

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Pubmed Data : Pharm Biol. 2013 Mar ;51(3):361-8. Epub 2012 Nov 8. PMID: 23137183

Article Published Date : Feb 28, 2013

Study Type : In Vitro Study

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Substances : Oak

Diseases : Cancers: All

Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Plant Extracts

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Anti-metastatic potential of natural triterpenoid cucurbitacin B against cholangiocarcinoma cells.Dec 31, 2021

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Pubmed Data : Integr Cancer Ther. 2022 Jan-Dec;21:15347354221124861. PMID: 36154723

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin B

Diseases : Cholangiocarcinoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors

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Antiangiogenic effect of capecitabine combined with ginsenoside Rg3 on breast cancer in mice.Sep 30, 2008

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Pubmed Data : Cancer Biother Radiopharm. 2008 Oct ;23(5):647-53. PMID: 18999937

Article Published Date : Sep 30, 2008

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Pubmed Data : Cancer Res. 2007 Mar 15 ;67(6):2816-23. PMID: 17363604

Article Published Date : Mar 14, 2007

Study Type : In Vitro Study

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Substances : Betulinic acid

Diseases : Prostate Cancer

Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Apoptotic, Vascular Endothelial Growth Factor Inhibitors

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Blueberry inhibits invasion and angiogenesis in chemically induced oral squamous cell carcinogenesis.Jun 18, 2016

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Pubmed Data : J Nutr Biochem. 2016 Jun 19 ;35:37-47. Epub 2016 Jun 19. PMID: 27371785

Article Published Date : Jun 18, 2016

Study Type : In Vitro Study

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Substances : Blueberry

Diseases : Oral Cancer, Oral Cancer: Prevention, Squamous cell carcinoma

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Anticarcinogenic Agents, MicroRNA modulator, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors

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Pubmed Data : Front Oncol. 2020 ;10:1756. Epub 2020 Sep 10. PMID: 33014864

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

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Substances : Tanshinone IIA

Diseases : Esophageal Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Bcl-2 protein down-regulation, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, P21 Activation, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

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Combined apigenin and gefitinib treatment presents an attractive strategy as alternative treatment for the acquired resistance to EGFR-TKIs in NSCLC.Dec 31, 2018

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Pubmed Data : Front Pharmacol. 2019 ;10:260. Epub 2019 Mar 22. PMID: 30967777

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Pubmed Data : Front Pharmacol. 2020 ;11:460. Epub 2020 Apr 8. PMID: 32322211

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

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Substances : Dandelion

Diseases : Liver Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Polysaccharides

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Pubmed Data : Mini Rev Med Chem. 2015 ;15(6):479-89. PMID: 25873069

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Substances : Apigenin, EGCG (Epigallocatechin gallate), Luteolin, Quercetin

Diseases : Cancers: All

Pharmacological Actions : Angiogenesis Inhibitors, Vascular Endothelial Growth Factor Inhibitors

[+]

In vitro antioxidative potential of lactoferrin and black tea polyphenols and protective effects in vivo on carcinogen activation.Dec 31, 2007

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Pubmed Data : J Ethnopharmacol. 2016 Jul 21 ;188:111-22. Epub 2016 May 10. PMID: 27178635

Article Published Date : Jul 20, 2016

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Plant Extracts

[+]

Low grade glioma cells appear much more sensitive to genistein.Dec 31, 2015

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Pubmed Data : Cell Oncol (Dordr). 2017 Jul 24. Epub 2017 Jul 24. PMID: 28741069

Article Published Date : Jul 23, 2017

Study Type : In Vitro Study

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Diseases : Breast Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Exosomes

[+]

Neferine reduces the cisplatin dose requirement in cancer chemotherapy.Feb 17, 2017

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Pubmed Data : J Cell Biochem. 2017 Feb 18. Epub 2017 Feb 18. PMID: 28214344

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Pubmed Data : Phytother Res. 2016 Jun ;30(6):963-70. Epub 2016 Mar 1. PMID: 26929026

Article Published Date : May 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Palmitoylethanolamide

Diseases : Colon Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Vascular Endothelial Growth Factor Inhibitors

[+]

Parthenolide inhibits angiogenesis in esophageal squamous cell carcinoma through suppression of VEGF.Dec 31, 2019

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Pubmed Data : Am J Chin Med. 2016 ;44(4):835-49. Epub 2016 May 24. PMID: 27222069

Tannic acid exhibits antiangiogenesis activity in nonsmall-cell lung cancer cells.Jul 11, 2022

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Pubmed Data : Int Ophthalmol. 2019 Mar ;39(3):725-734. Epub 2018 Feb 5. PMID: 29404861

Article Published Date : Feb 28, 2019

Study Type : Review

Additional Links

Substances : Curcumin

Diseases : Diabetic Retinopathy, Eye Cancer, Macular Degeneration, Proliferative Vitreoretinopathy (PVR), Retinitis Pigmentosa

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Vascular Endothelial Growth Factor Inhibitors

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These data suggest the suitability of lower fucoidan doses to limit angiogenesis for instance in osteosarcoma.Jun 19, 2017

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Pubmed Data : Mar Drugs. 2017 Jun 20 ;15(6). Epub 2017 Jun 20. PMID: 28632184

Article Published Date : Jun 19, 2017

Study Type : In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Osteosarcoma

Pharmacological Actions : Angiogenesis Inhibitors, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Bone Regeneration

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These findings provide new insights into understanding the anticancer mechanisms of berberine in human lung cancer therapy.Dec 31, 2012

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Pubmed Data : J Tradit Complement Med. 2015 Apr ;5(2):66-70. Epub 2015 Jan 16. PMID: 26151013

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Pubmed Data : Int Immunopharmacol. 2016 May 27 ;38:70-80. Epub 2016 May 27. PMID: 27240137

Article Published Date : May 26, 2016

Study Type : In Vitro Study

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Substances : Thymoquinone

Diseases : Asthma

Pharmacological Actions : Anti-Inflammatory Agents, Vascular Endothelial Growth Factor Inhibitors

[+]

This study indicated that a hydroalcoholic extract of P. harmala seeds contains a potent anti-angiogenic component.May 31, 2015

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Pubmed Data : Pharm Biol. 2015 Jun ;53(6):855-61. Epub 2014 Dec 4. PMID: 25471082

Article Published Date : May 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Syrian rue

Diseases : Cancers: All

Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Plant Extracts

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CoQ10 supplementation reduced some of the important markers of inflammation and MMPs in patients with breast cancer.May 31, 2021

Delta9-tetrahydrocannabinol administration led to the inhibition of the VEGF Pathway in Two Patients with Glioblastoma Multiforme.Aug 14, 2004

Ginsenoside Rg3 inhibits HIF-1α and VEGF expression in patients with acute leukemia.Dec 31, 2013

Intake of bilberries has an ameliorating effect on some markers of gingival inflammation reducing gingivitis to a similar extent compared to standard of care.Dec 31, 2014

Local ice cryotherapy had beneficial effects in human non-septic knee arthritis.Jul 29, 2019

Powdered Nigella sativa has potent beneficial effects in improving thyroid status and anthropometric variables.Nov 15, 2016

Resveratrol may improve some outcomes of PCOS patients.Jul 20, 2019

The influences of vitamin D and omega-3 co-supplementation on clinical, metabolic and genetic parameters in women with polycystic ovary syndrome.Sep 30, 2018

These findings support the potential role of flaxseed in treating dyslipidaemia.Jul 12, 2022

Two months' of treatment with Z. multiflora improved cytokine levels, respiratory symptom, and FEV1 values in sulfur mustard-exposed patients.Apr 19, 2020

Vitamin D Decreases Serum VEGF Correlating with Clinical Improvement in Vitamin D-Deficient Women with polycystic ovary syndrome.Mar 27, 2017

A Black Raspberry extract could prevent the initiation, promotion, and progression of carcinogenesis in the digestive tract and esophagus.Oct 27, 2014

Melatonin has anti-angiogenic effects at different steps of the angiogenic process in SH-SY5Y neuroblastoma cells.Feb 13, 2017

VEGF is a key molecular target for specific polyphenols found in tea, apples and cocoa which potently inhibit VEGF signalling and angiogenesis at physiological concentrations.Feb 28, 2015

Acacetin inhibits in vitro and in vivo angiogenesis and downregulates Stat signaling and VEGF expression.Sep 30, 2013

Ferulic acid nanocapsules as a promising treatment modality for colorectal cancer.May 31, 2022

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

6-gingerol delays tumorigenesis in benzo[a]pyrene and dextran sulphate sodium-induced colorectal cancer. Jun 04, 2020

A ashwagandha water extract suppressed the tumor growth of glioma cells.Jul 25, 2015

A Huaier polysaccharide restrains hepatocellular carcinoma growth and metastasis.Mar 31, 2015

A purple corn extract may be a potent therapeutic agent targeting abnormal angiogenesis in diabetic nephropathy leading to kidney failure.Dec 31, 2012

Açaí is a promising novel pharmacological therapeutic treatment for endometriosis.Dec 31, 2015

Administration of thymol afforded remarkable protection against high fat diet induced diabetic nephropathy.Feb 04, 2016

An aqueous extract of Bixa orellana showed anti-inflammatory properties in serotonin-induced acute inflammation.Dec 31, 2012

An immune-modulating diet in combination with chemotherapy prevented cancer cachexia without suppressing chemotherapeutic efficacy.Jul 01, 2015

Andrographolide ameliorates diabetic retinopathy by inhibiting retinal angiogenesis and inflammation.Mar 31, 2015

Annona muricata leaves showed an ameliorative effect in a murine model of breast cancer.Mar 09, 2022

Anti-angiogenic effect of shikonin in rheumatoid arthritis.May 31, 2020

Antitumor activity of ginsenoside Rg3 in melanoma through downregulation of the ERK and Akt pathways.May 31, 2019

Apoptosis induction and ERK/NF-κB inactivation are associated with magnolol-inhibited tumor progression in hepatocellular carcinoma.Nov 11, 2019

Arctigenin prevents retinal edema in a murine retinal vein occlusion model. Dec 31, 2022

Astaxanthin inhibits homocysteine‑induced endothelial cell dysfunction.Apr 11, 2019

Astragaloside IV and curcumin alone and in combination significantly reduced mean tumor weight compared to vehicle control.Dec 31, 2016

Bamboo leaf extract could improve wound closure by 28 % at 12 hours and 54 % at 24 hours in mice.Nov 30, 2014

Berberine improves insulin-induced diabetic retinopathy in type I and II diabetes.Dec 31, 2020

Betaine may potentially be used to delay the onset of complications associated with diabetic retinopathy via inhibition of retinal neovascularization in patients with diabetes.Jul 31, 2015

Biochanin A regulates the growth and migration of NSCLC through suppressing the VEGF/VEGFR2 signaling pathway.Jul 22, 2018

Boswellic acid suppresses growth and metastatis of human pancreatic tumors (nude mouse model). Jan 01, 2011

Caffeic acid phenethyl ester mitigates infertility: A crucial role of metalloproteinase and angiogenic factor in cadmium-induced testicular damage.Nov 16, 2021

Camel milk inhibits inflammatory angiogenesis via downregulation of proangiogenic and proinflammatory cytokines in mice.Jun 30, 2014

Chebulinic acid is a safe and effective antiangiogenic agent in collagen-induced arthritis in mice.Jan 22, 2020

Crocin and Metformin suppress metastatic breast cancer progression.Apr 29, 2021

Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis.Sep 07, 2010

Curcumin inhibits lymphangiogenesis in vitro and in vivo, which could contribute to the antimetastatic effects of curcumin.Aug 26, 2015

Curcumin not only inhibits tumor angiogenesis, but also suppresses the production of VEGF in response to hypoxia.Aug 13, 2015

Curcumin treated animals had a significant reduction in tumor growth as measured by the decrease in size of the subcutaneous xenografts compared to untreated animals.Jun 07, 2015

Delphinidin is a promising compound to prevent pathologies associated with generation of vascular network in tumorigenesis.Dec 31, 2014

Dendrosomal curcumin has a chemoprotective effect on the breast cancer metastasis through suppression of NF-κB and its regulated gene products.Jul 04, 2015

Didymin by suppressing NF-κB activation prevents VEGF-induced angiogenesis in vitro and in vivo.Dec 31, 2018

Dietary administration of garcinol effectively reduced the tumor size and incidence in the mouse colon.Aug 31, 2014

Effect of total glucosides of paeony on imiquimod-induced psoriatic skin lesions.Dec 31, 2020

EGCG can be developed into a potential agent for the prevention and treatment of smoking‑associated NSCLC.May 31, 2015

Electroacupuncture ameliorates inflammatory response of mice with acute myocardial ischemia.Oct 24, 2022

Ellagic acid exerted protective effects against carbon tetrachloride-induced cirrhosis through the inhibition of ROS formation and angiogenesis.Sep 30, 2017

Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug.Jan 31, 2016

Eriodictyol prevents early retinal and plasma abnormalities in streptozotocin-induced diabetic rats.Jun 30, 2012

Essential oil of Pinus koraiensis leaves has anti-diabetic potential.Dec 31, 2012

Evaluation of antiangiogenic and antiproliferative potential of the organic extract of green algae Chlorella pyrenoidosa.Dec 31, 2012

Extra virgin olive oil modulates vasodilator enzyme level by repairing angiogenesis function in rat model of preeclampsia.Feb 29, 2020

Galangin inhibits epithelial-mesenchymal transition and angiogenesis by downregulating CD44 in glioma.Dec 31, 2018

Genistein mediated upregulation of CHOP impeded C/EBPβ interaction with the IL-6 promoter, thus disturbing the angiogenic microenvironment which inhibited tumor proliferation.May 31, 2015

Geraniol is an attractive candidate for the anti-angiogenic treatment of tumors.Dec 31, 2014

Ginkgo biloba exocarp extracts played the effects of anti-tumor and anti-metastatic depending upon the inhibition of tumor angiogenesis.Nov 03, 2016

Ginsenoside Rg3 nanoparticle may suppress the expression of VEGF, MMP-9 and HIF-1α in Lewis lung cancer mice.Jun 17, 2016

Ginsenoside Rg3 significantly inhibited growth and angiogenesis of ovarian cancer when used alone or combined with cyclophosphamide.Apr 04, 2007

Ginsenoside-Rg3 can down-regulate the expression of VEGF and TNF-α in retina.Dec 31, 2009

GinsenosideRg3 can be employed as an early intervention and a combining therapeutic aid to reduce inflammation and hypertrophic scar formation.Dec 31, 2013

Glabridin ameliorates diabetic nephropathy.Jan 19, 2022

Hesperidin as adjuvant therapy with DOX would enhance the therapeutic efficacy and alleviate the resistance to DOX in treatment of solid tumors.Jun 22, 2015

Hesperidin suppressed metastasis, angiogenesis and tumour growth in Balb/c mice model of breast cancer.Aug 31, 2023

Honokiol has a significant anti-nociceptive activity through inhibition of anti-inflammatory mediators.Dec 31, 2017

Hyperbaric oxygen therapy could inhibit glioma cell proliferation and inflammatory cell infiltration.Oct 31, 2016

Vascular Endothelial Growth Factor Inhibitors

View the Evidence:
309 Abstracts with Vascular Endothelial Growth Factor Inhibitors Research