Wnt/β-catenin pathway down-regulation

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52 Substances Researched for Wnt/β-catenin pathway down-regulation
NameACCKFocus
Resveratrol211Locked
Grapes110Locked
Curcumin78Locked
Apigenin26Locked
Sulforaphane26Locked
Panax Notoginseng15Locked
Parthenolide15Locked
Baicalein23Locked
EGCG (Epigallocatechin gallate)23Locked
Flavonoids33Locked
Fucoidan23Locked
Anthocyanins12Locked
Berberine12Locked
Caraway Oil12Locked
Cardamonin12Locked
Cucurbitacin B 22Locked
Ginkgo biloba12Locked
Lotus 12Locked
Oleuropein12Locked
Paeoniflorin22Locked
Potato: Pigmented12Locked
Puerarin12Locked
Traditional Chinese Medicine: Compound Kushen Injection12Locked
Vitamin D12Locked
6-Shogaol11Locked
Apple Polyphenols11Locked
Arctigenin11Locked
Artemisinin11Locked
Artesunate11Locked
Bai Zhu11Locked
Bisdemethoxycurcumin11Locked
Celastrol11Locked
Cinnamaldehyde11Locked
Citral11Locked
Cucurbitacin E 11Locked
Diosgenin11Locked
Genistein11Locked
Ginsenosides11Locked
Lactobacillus plantarum11Locked
Lactobacillus rhamnosus 11Locked
Luteolin11Locked
Lycopene11Locked
Persimmon 11Locked
Piperine11Locked
Reishi Mushroom11Locked
Salvia miltiorrhiza11Locked
Thymoquinone11Locked
Tocotrienol: Gamma11Locked
Trichosanthes Kirilowii 11Locked
Vitamin C11Locked
Vitamin E: Gamma-tocotrienol11Locked
beta-Carotene11Locked

View the Evidence:
58 Abstracts with Wnt/β-catenin pathway down-regulation Research

[+]

Dietary grape supplementation may play a role in colon cancer prevention for high-risk individuals. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr J. 2015 ;14(1):62. Epub 2015 Jun 19. PMID: 26085034
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Grapes, Resveratrol
Diseases : Colon Cancer: Prevention
Pharmacological Actions : Chemopreventive, Wnt/β-catenin pathway down-regulation
Additional Keywords : Dietary Concentrations, Risk Reduction
[+]

Apigenin is a promising chemotherapeutic agent that may be used in the treatment of human osteosarcoma.Jul 31, 2015

Pubmed Data : Oncol Rep. 2015 Aug ;34(2):1035-41. Epub 2015 May 29. PMID: 26035210
Article Published Date : Jul 31, 2015
Study Type : Human In Vitro
Additional Links
Substances : Apigenin
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Chemotherapeutic, Wnt/β-catenin pathway down-regulation
[+]

Ginsenoside-Rb1 targets chemotherapy-resistant ovarian cancer stem cells.Nov 03, 2016

Pubmed Data : Oncotarget. 2016 Nov 4. Epub 2016 Aug 4. PMID: 27825116
Article Published Date : Nov 03, 2016
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Panax Notoginseng
Diseases : Cancers: Drug Resistant, Ovarian Cancer
Pharmacological Actions : Chemosensitizer, Wnt/β-catenin pathway down-regulation
Additional Keywords : Chemotherapeutic Synergy: Cisplatin, Drug Resistant Cancer Stem Cells
[+]

Parthenolide may be a promising component for bone regeneration in periodontitis treatment.Aug 21, 2017

Pubmed Data : J Interferon Cytokine Res. 2017 Aug 22. Epub 2017 Aug 22. PMID: 28829282
Article Published Date : Aug 21, 2017
Study Type : Human In Vitro
Additional Links
Substances : Parthenolide
Diseases : Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Wnt/β-catenin pathway down-regulation
Additional Keywords : Bone Regeneration
[+]

Sulforaphane inhibits Wnt/β-catenin signaling in colorectal cancer cells, supressing proliferation and inducing cell death.Sep 21, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2018 Sep 21 ;9(74):33982-33994. Epub 2018 Sep 21. PMID: 30338040
Article Published Date : Sep 21, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Wnt/β-catenin pathway down-regulation
Additional Keywords : Anti-cancer
[+]

Anthocyanin containing purple fleshed potatoes suppressed colon tumorigenesis via elimination of colon cancer stem cells.Aug 13, 2015

Pubmed Data : J Nutr Biochem. 2015 Aug 14. Epub 2015 Aug 14. PMID: 26383537
Article Published Date : Aug 13, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Anthocyanins, Potato: Pigmented
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Wnt/β-catenin pathway down-regulation
Additional Keywords : Cancer Stem Cells, Natural Substances Versus Drugs, Plant Extracts
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Baicalein has the potential to suppress breast cancer metastasis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2016 ;10:1419-41. Epub 2016 Apr 18. PMID: 27143851
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Baicalein
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Wnt/β-catenin pathway down-regulation
[+]

Cardamonin treatment effectively blocked TLR3 activation-induced Cancer stem cells in vitro and in a mouse xenograft model.Jan 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Differ. 2015 Feb ;22(2):298-310. Epub 2014 Sep 26. PMID: 25257174
Article Published Date : Jan 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Cardamonin
Diseases : Breast Cancer
Pharmacological Actions : NF-kappaB Inhibitor, Wnt/β-catenin pathway down-regulation
Additional Keywords : Cancer Stem Cells
[+]

Compound Kushen Injection suppresses human breast cancer stem-like cells. Jan 01, 2011

Pubmed Data : J Exp Clin Cancer Res. 2011 ;30:103. Epub 2011 Oct 28. PMID: 22032476
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Traditional Chinese Medicine: Compound Kushen Injection
Diseases : Breast Cancer, Cancer Stem Cells
Pharmacological Actions : Antineoplastic Agents, Wnt/β-catenin pathway down-regulation
Additional Keywords : Cancer Stem Cells
[+]

Curcumin is able to alleviate the harmful reaction of leptin on podocytes and reduce the severity of obesity-related glomerulopathy.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:827472. Epub 2015 Oct 11. PMID: 26539236
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Glomerulosclerosis, Leptin: Elevated Levels, Obesity
Pharmacological Actions : Renoprotective, Wnt/β-catenin pathway down-regulation
[+]

EGCG significantly inhibited gastric tumour growth in vivo by inhibiting Wnt/β-catenin signalling. Jun 23, 2016

Pubmed Data : Int J Food Sci Nutr. 2016 Jun 24:1-10. Epub 2016 Jun 24. PMID: 27338284
Article Published Date : Jun 23, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive, Wnt/β-catenin pathway down-regulation
[+]

Fucoidan may be an effective therapy for the chemoprevention and treatment of breast cancer.Dec 31, 2012

Pubmed Data : Nutr Cancer. 2013 ;65(3):460-8. PMID: 23530646
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Wnt/β-catenin pathway down-regulation
[+]

Ginkgo biloba exocarp extracts played the effects of anti-tumor and anti-metastatic depending upon the inhibition of tumor angiogenesis.Nov 03, 2016

Pubmed Data : J Ethnopharmacol. 2016 Nov 4 ;192:406-412. Epub 2016 Aug 17. PMID: 27649680
Article Published Date : Nov 03, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Lung Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Vascular Endothelial Growth Factor Inhibitors, Wnt/β-catenin pathway down-regulation
Additional Keywords : Dose Response
[+]

Nuciferine not only inhibited the growth of NSCLC cells, but also remarkably alleviated the injury induced by nicotine in liver function.May 12, 2015

Pubmed Data : J Ethnopharmacol. 2015 May 13 ;165:83-93. Epub 2015 Feb 16. PMID: 25698245
Article Published Date : May 12, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer, Nicotine/Tobacco Toxicity
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 Ratio: Decrease, Hepatoprotective, Wnt/β-catenin pathway down-regulation
[+]

Oleuropein supplementation could be a promising protective agent against colitis-associated colorectal cancer.Sep 28, 2015

Pubmed Data : Mol Nutr Food Res. 2015 Sep 29. Epub 2015 Sep 29. PMID: 26502315
Article Published Date : Sep 28, 2015
Study Type : Animal Study
Additional Links
Substances : Oleuropein
Diseases : Colitis, Colorectal Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Interferon Gamma Reducer, Interleukin-17 downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Wnt/β-catenin pathway down-regulation
[+]

Our results indicate that berberine can be a potential chemoprevention and chemotherapy agent for human colon cancer by targeting Wnt/β-catenin signaling.Apr 01, 2012

Pubmed Data : Int J Oncol. 2012 Apr 2. Epub 2012 Apr 2. PMID: 22469784
 
Article Published Date : Apr 01, 2012
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Colon Cancer
Pharmacological Actions : Wnt/β-catenin pathway down-regulation
[+]

The combined application of vitamin D and puerarin is capable of alleviating carbon tetrachloride-induced hepatic fibrosis.Sep 27, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2018 Sep 28 ;24(36):4178-4185. PMID: 30271082
Article Published Date : Sep 27, 2018
Study Type : Animal Study
Additional Links
Substances : Puerarin, Vitamin D
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, Wnt/β-catenin pathway down-regulation
Additional Keywords : Natural Substance Synergy
[+]

These results indicate with colon cancer expression of colonic β-catenin is altered in long-term caraway oil feeding, leading to suppression of premalignant lesions in rat colon.Mar 14, 2012

Pubmed Data : J Nat Med. 2012 Mar 15. Epub 2012 Mar 15. PMID: 22418855
Article Published Date : Mar 14, 2012
Study Type : Animal Study
Additional Links
Substances : Caraway Oil
Diseases : Colon Cancer, Colon Polyps
Pharmacological Actions : Wnt/β-catenin pathway down-regulation
[+]

6-shogaol suppresses the progression of liver cancer.Dec 31, 2020

Pubmed Data : Am J Chin Med. 2021 ;49(8):2033-2048. PMID: 34961414
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin pathway down-regulation
[+]

A. macrocephala might be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2015 Jan ;23(1):26-30. Epub 2015 Jan 1. PMID: 25593640
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Bai Zhu
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Chemotherapeutic, Wnt/β-catenin pathway down-regulation
[+]

Anticancer activity of calyx of Diospyros kaki Thunb. Sep 04, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2017 Sep 5 ;17(1):445. Epub 2017 Sep 5. PMID: 28870200
Article Published Date : Sep 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Persimmon
Diseases : Colorectal Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cyclin D1 Down-Regulation, Wnt/β-catenin pathway down-regulation
Additional Keywords : Plant Extracts
[+]

Antitumor activity of luteolin against ehrlich solid carcinoma.Apr 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cureus. 2023 May ;15(5):e39789. Epub 2023 May 31. PMID: 37265908
Article Published Date : Apr 30, 2023
Study Type : In Vitro Study
Additional Links
Substances : Luteolin
Diseases : Ehrlich carcinoma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Wnt/β-catenin pathway down-regulation
[+]

Apigenin significantly suppressed colorectal cancer cell proliferation, migration, invasion and organoid growth.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2016 May ;11(5):3075-3080. Epub 2016 Mar 16. PMID: 27123066
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Apigenin
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Wnt/β-catenin pathway down-regulation
Additional Keywords : Dose Response
[+]

Apple extracts inhibit the WNT pathway in colon cells carrying familial adenomatous polyposismutations.Nov 17, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Nov 18 ;9(11). Epub 2017 Nov 18. PMID: 29156563
Article Published Date : Nov 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Colon Cancer
Pharmacological Actions : Chemopreventive, Wnt/β-catenin pathway down-regulation
[+]

Arctigenin induced anti-metastatic and anti-angiogenesis activities were mainly accompanied by a deactivation of the Wnt/β-catenin pathway in HCT116 cells.Aug 11, 2015

Pubmed Data : Mol Biosyst. 2015 Aug 12. Epub 2015 Aug 12. PMID: 26267229
Article Published Date : Aug 11, 2015
Study Type : In Vitro Study
Additional Links
Substances : Arctigenin
Diseases : Colon Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Wnt/β-catenin pathway down-regulation
[+]

Artesunate could suppress lung-tumor progression by inhibiting Wnt/β-catenin pathway.Apr 21, 2016

Pubmed Data : Oncotarget. 2016 Apr 22. Epub 2016 Apr 22. PMID: 27119499
Article Published Date : Apr 21, 2016
Study Type : In Vitro Study
Additional Links
Substances : Artemisinin, Artesunate
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Anti-metastatic, Anticarcinogenic Agents, Antiproliferative , Cell cycle arrest, Wnt/β-catenin pathway down-regulation
[+]

Bisdemethoxycurcumin inhibits Wnt/β-catenin pathway by increasing WIF-1 expression, which subsequently leads to suppression of TGF-β1-induced EMT migration.Dec 31, 1969

Study Type : In Vitro Study
Additional Links
Substances : Bisdemethoxycurcumin, Curcumin
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Anti-metastatic, Wnt/β-catenin pathway down-regulation
[+]

Cinnamaldehyde is able to inhibit NSCLC cell growth by inducing apoptosis and reverse epithelial-mesenchymal transition.Jan 15, 2017

Pubmed Data : Int J Biochem Cell Biol. 2017 Jan 16 ;84:58-74. Epub 2017 Jan 16. PMID: 28093328
Article Published Date : Jan 15, 2017
Study Type : In Vitro Study
Additional Links
Substances : Cinnamaldehyde
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Anti-metastatic, Apoptotic, Wnt/β-catenin pathway down-regulation
[+]

Cucurbitacin B inhibited the metastatic abilities of NSCLC through the inhibition of Wnt/β-catenin signaling axis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 ;6:21860. Epub 2016 Feb 24. PMID: 26905250
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Non-Small-Cell Lung Carcinoma
Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative , Apoptotic, Wnt/β-catenin pathway down-regulation
[+]

Cucurbitacin B may in part induce apoptosis and exert growth inhibitory effect via interruption the Wnt signaling.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Biochem. 2012 Jan ;113(1):49-60. PMID: 21866566
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Wnt/β-catenin pathway down-regulation
[+]

Cucurbitacin E inhibited Wnt/β-catenin signaling activation through upregulation of tumor suppressor Menin.May 31, 2014

Pubmed Data : Cancer Biother Radiopharm. 2014 Jun ;29(5):210-4. Epub 2014 Jun 2. PMID: 24885795
Article Published Date : May 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin E
Diseases : Colon Cancer, Liver Cancer, Lung Cancer
Pharmacological Actions : Antiproliferative , Wnt/β-catenin pathway down-regulation
[+]

Curcumin exhibited its interventional effect on lung cancer stem cells via inhibition of Wnt/β-catenin and Sonic Hedgehog pathways.Feb 14, 2017

Pubmed Data : Phytother Res. 2017 Feb 15. Epub 2017 Feb 15. PMID: 28198062
Article Published Date : Feb 14, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin pathway down-regulation
Additional Keywords : Cancer Stem Cells
[+]

Curcumin inhibited oral squamous cell carcinoma cells proliferation through up-regulating miR-9 expression, and suppressing Wnt/β-catenin signaling.Oct 29, 2014

Pubmed Data : Biochem Biophys Res Commun. 2014 Oct 30 ;454(4):576-580. Epub 2014 Oct 30. PMID: 25450696
Article Published Date : Oct 29, 2014
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , MicroRNA modulator, Wnt/β-catenin pathway down-regulation
[+]

Curcumin inhibits proliferation,migration and invasion of gastric cancer cells via Wnt3a/β-catenin/EMT signaling pathway.Jun 30, 2019

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2019 Jul ;44(14):3107-3115. PMID: 31602860
Article Published Date : Jun 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin pathway down-regulation
[+]

Curcumin targets numerous therapeutically important cancer signalling pathways.Jul 27, 2016

Pubmed Data : Tumour Biol. 2016 Jul 28. Epub 2016 Jul 28. PMID: 27468716
Article Published Date : Jul 27, 2016
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Tumor Suppressor Protein p53 Upregulation, Wnt/β-catenin pathway down-regulation
Additional Keywords : Tumor Microenvironment
[+]

Diosgenin inhibits Wnt/β-catenin pathway to regulate the proliferation and differentiation of MG-63 cells.Mar 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cytotechnology. 2021 Apr ;73(2):169-178. Epub 2021 Feb 5. PMID: 33927474
Article Published Date : Mar 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Diosgenin
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation, Wnt/β-catenin pathway down-regulation
[+]

Gamma tocotrienol led to suppression of metastatic breast cancer cell proliferation.Jun 20, 2016

Pubmed Data : Cell Prolif. 2016 Jun 21. Epub 2016 Jun 21. PMID: 27323693
Article Published Date : Jun 20, 2016
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Gamma
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Wnt/β-catenin pathway down-regulation
Additional Keywords : Dose Response
[+]

Ginsenoside Rh4 suppresses metastasis of esophageal cancer.Jul 24, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2022 Jul 25 ;14(15). Epub 2022 Jul 25. PMID: 35893895
Article Published Date : Jul 24, 2022
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Esophageal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Wnt/β-catenin pathway down-regulation
[+]

Inhibitory effects on melanogenesis by thymoquinone are mediated through the β‑catenin pathway in B16F10 mouse melanoma cells.Dec 01, 2019

Pubmed Data : Int J Oncol. 2019 Dec 2. Epub 2019 Dec 2. PMID: 31789395
Article Published Date : Dec 01, 2019
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Melanoma
Pharmacological Actions : Wnt/β-catenin pathway down-regulation
[+]

Isoorientin inhibits epithelial-to-mesenchymal properties and cancer stem-cell-like features in oral squamous cell carcinoma.Dec 31, 2020

Pubmed Data : Toxicol Appl Pharmacol. 2021 08 1 ;424:115581. Epub 2021 May 18. PMID: 34019859
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Squamous cell carcinoma
Pharmacological Actions : STAT3 Inhibitor, Wnt/β-catenin pathway down-regulation
Additional Keywords : Cancer Stem Cells
[+]

It is hypothesized that baicalin exerts cardioprotective effects via suppression of the Wnt/β catenin signalling pathway.Oct 09, 2017

Pubmed Data : Mol Med Rep. 2017 Oct 10. Epub 2017 Oct 10. PMID: 29039516
Article Published Date : Oct 09, 2017
Study Type : In Vitro Study
Additional Links
Substances : Baicalein
Diseases : Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Cardioprotective, Wnt/β-catenin pathway down-regulation
[+]

Lycopene might be a potential and promising nutrient for preventing H pylori-associated gastric diseases including gastric cancer.Jul 20, 2018

Pubmed Data : Nutr Res. 2018 Jul 21. Epub 2018 Jul 21. PMID: 30098838
Article Published Date : Jul 20, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lycopene
Diseases : Gastric Cancer, Helicobacter Pylori Infection
Pharmacological Actions : Antiproliferative , Chemopreventive, Wnt/β-catenin pathway down-regulation
[+]

Lycorine inhibits tumor growth of human osteosarcoma cells.Dec 31, 2019

Pubmed Data : Am J Transl Res. 2020 ;12(9):5381-5398. Epub 2020 Sep 15. PMID: 33042426
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Osteosarcoma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Cell cycle arrest, Wnt/β-catenin pathway down-regulation
[+]

Paeoniflorin affects hepatocellular carcinoma progression by inhibiting Wnt/β-catenin pathway.Oct 08, 2020

Pubmed Data : Curr Pharm Biotechnol. 2020 Oct 9. Epub 2020 Oct 9. PMID: 33038910
Article Published Date : Oct 08, 2020
Study Type : In Vitro Study
Additional Links
Substances : Paeoniflorin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Wnt/β-catenin pathway down-regulation
[+]

Paeoniflorin inhibits Wnt1/β-catenin pathway and promotes apoptosis of fibroblast-like synoviocytes in patients with rheumatoid arthritis.Jul 31, 2022

Pubmed Data : Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2022 Aug ;38(8):692-698. PMID: 35851082
Article Published Date : Jul 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Paeoniflorin
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Apoptotic, Wnt/β-catenin pathway down-regulation
[+]

Probiotic substances may be useful therapeutic alternatives as biotherapeutics for chemo-resistant colorectal cancer.May 24, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Microbiol Biotechnol. 2016 May 25. Epub 2016 May 25. PMID: 27221111
Article Published Date : May 24, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lactobacillus plantarum
Diseases : Cancers: Drug Resistant, Colorectal Cancer
Pharmacological Actions : Chemosensitizer, Wnt/β-catenin pathway down-regulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Drug Resistant Cancer Stem Cells
[+]

Reishi may be a potential natural inhibitor for breast cancer.Apr 16, 2017

Pubmed Data : Biochem Biophys Res Commun. 2017 Apr 17. Epub 2017 Apr 17. PMID: 28427938
Article Published Date : Apr 16, 2017
Study Type : In Vitro Study
Additional Links
Substances : Reishi Mushroom
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative , Wnt/β-catenin pathway down-regulation
[+]

Resveratrol suppressed the MG 63 cells by inhibiting the canonical Wnt signaling pathway.Sep 20, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2015 Sep 21. Epub 2015 Sep 21. PMID: 26398440
Article Published Date : Sep 20, 2015
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Wnt/β-catenin pathway down-regulation
[+]

Sinensetin suppresses breast cancer cell progression via Wnt/β-catenin pathway inhibition.Jan 30, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Transl Cancer Res. 2024 Jan 31 ;13(1):348-362. Epub 2024 Jan 12. PMID: 38410229
Article Published Date : Jan 30, 2024
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin pathway down-regulation
[+]

Taxifolin improves inflammatory injury of human bronchial epithelial cells.Dec 31, 2021

Pubmed Data : Bioengineered. 2022 01 ;13(1):1198-1208. PMID: 35000533
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Wnt/β-catenin pathway down-regulation
[+]

The results suggest that citral could be a potential new agent which can eliminate drug-resistant breast cancer cells.Feb 12, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2018 Feb 13 ;18(1):56. Epub 2018 Feb 13. PMID: 29433490
Article Published Date : Feb 12, 2018
Study Type : In Vitro Study
Additional Links
Substances : Citral
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Wnt/β-catenin pathway down-regulation
[+]

The results suggest that trichosanthin may induce apoptosis in glioma cells.Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2015 Dec ;34(6):2845-52. Epub 2015 Sep 18. PMID: 26397053
Article Published Date : Nov 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Trichosanthes Kirilowii
Diseases : Glioma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Wnt/β-catenin pathway down-regulation
Additional Keywords : Dose Response
[+]

The use of phytochemicals may be a true therapeutic strategy for eradicating cancer through the elimination of CSCs.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2015 ;16(7):15727-42. Epub 2015 Jul 10. PMID: 26184171
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : beta-Carotene, Curcumin, EGCG (Epigallocatechin gallate), Genistein, Piperine, Sulforaphane
Diseases : Cancer Stem Cells, Cancers: All
Pharmacological Actions : Chemopreventive, Wnt/β-catenin pathway down-regulation
Additional Keywords : Drug Resistance, Selective Cytotoxicity
[+]

These data support that fucoidan might have potential for the treatment of prostate cancer.Aug 18, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2013 Aug 19 ;11(8):2982-99. Epub 2013 Aug 19. PMID: 23966032
Article Published Date : Aug 18, 2013
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Wnt/β-catenin pathway down-regulation
[+]

This study is the first report that assessed the potential impact of L. rhamnosus, especially its supernatant on esophageal cancer.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2022 ;2022:7607470. Epub 2022 Jun 24. PMID: 35782061
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Lactobacillus rhamnosus
Diseases : Esophageal Cancer
Pharmacological Actions : Antiproliferative , Wnt/β-catenin pathway down-regulation
[+]

TRAIL and celastrol combinational treatment suppresses proliferation, migration, and invasion of human glioblastoma cells.Mar 31, 2024

Pubmed Data : Chin J Integr Med. 2024 Apr ;30(4):322-329. Epub 2023 Oct 20. PMID: 37861963
Article Published Date : Mar 31, 2024
Study Type : In Vitro Study
Additional Links
Substances : Celastrol
Diseases : Glioblastoma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Wnt/β-catenin pathway down-regulation
[+]

Vitamin C suppresses pancreatic carcinogenesis.Oct 13, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2022 Oct 14 ;23(20). Epub 2022 Oct 14. PMID: 36293106
Article Published Date : Oct 13, 2022
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive, Wnt/β-catenin pathway down-regulation
[+]

γ-Tocotrienol inhibited cell proliferation and induced a paraptosis-like cell death in human colon cancer cell and may be a potential treatment to prevent and treat apoptosis-resistance colon cancer.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(2):e57779. Epub 2013 Feb 28. PMID: 23469066
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Vitamin E: Gamma-tocotrienol
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Antiproliferative , Caspase-3 Activation, Paraptosis, Wnt/β-catenin pathway down-regulation
Additional Keywords : Dose Response, Treatment Resistant

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