Wnt/β-catenin signaling pathway modulation

Name	AC	CK
Curcumin	18	26
Quercetin	9	10
Berberine	7	8
Resveratrol	3	8
Ginsenosides	6	7
Ellagic Acid	5	6
Ginger	2	6
Crocin	3	5
Astragaloside	2	4
EGCG (Epigallocatechin gallate)	3	4
Luteolin	4	4
Apigenin	3	3
Benzyl isothiocyanate	2	3
Cardamonin	2	3
Gastrodin	2	3
Oridonin	2	3
Panax Notoginseng	2	3
Polyphenols	2	3
Sesamin	2	3
Sulforaphane	3	3
Theaflavins	2	3
Vitamin D	2	3
Xanthohumol	2	3
Arctigenin	1	2
Artesunate	1	2
Bee Propolis	1	2
Beta-Elemene	2	2
Betulinic acid	1	2
Caffeic acid phenethyl ester	1	2
Cinnamaldehyde	1	2
Delphinidin	2	2
Eugenol	1	2
Flavonoids	2	2
Garlic	2	2
Geraniol	1	2
Grape Seed Extract	1	2
Guava	1	2
Hawthorn	1	2
Hesperidin	1	2
Huperzine	1	2
Isoliquiritigenin	1	2
Kaempferol	1	2
Mangiferin	2	2
Nobiletin	2	2
Piperine	2	2
Piperlongumine	2	2
Pomegranate	2	2
Puerarin	2	2
Reishi Mushroom	2	2
Rutin	2	2
Salvia miltiorrhiza	1	2
Thymol	1	2
Thymoquinone	1	2
Ursolic Acid	2	2
Wogonin	2	2
4-Shogaol	1	1
6-Shogaol	1	1
Agaricus Blazei	1	1
Anthocyanins	1	1
Bai Zhu	1	1
Baicalein	1	1
Barberry	1	1
Berbamine	1	1
Bitter Apple	1	1
Bitter Melon	1	1
Broccoli	1	1
Broccoli Sprouts	1	1
Caffeic Acid	1	1
Cannabidiol	1	1
Capsaicin	1	1
Chlorophyllin	1	1
Chokeberry	1	1
Chrysin	1	1
Coumestrol	1	1
Crocetin	1	1
Deguelin	1	1
Diosgenin	1	1
Echinacea	1	1
Emodin	1	1
Fisetin	1	1
Genistein	1	1
Gingerol	1	1
Ginkgo biloba	1	1
Ginseng (Korean)	1	1
Ginseng (Siberian)	1	1
Green Tea	1	1
Honey	1	1
Honeysuckle	1	1
Indole-3-Carbinol	1	1
Lignans	1	1
Lupeol	1	1
Melatonin	1	1
Mulberry	1	1
Myricetin	1	1
Noni	1	1
Oleanolic acid	1	1
Paeonol	1	1
Parthenolide	1	1
Phenethyl isothiocyanate	1	1
Phyllanthus amarus	1	1
Piceatannol	1	1
Proanthocyanidins	1	1
Pterostilbene	1	1
Saffron	1	1
Silymarin	1	1
Tanshinone IIA	1	1
Urolithin A	1	1
Vanillin	1	1
Water: Deep Sea	1	1

[+]

Indonesian ginger extract promotes neurogenesis of human neural stem cells.Jul 04, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2020 Jul 5 ;21(13). Epub 2020 Jul 5. PMID: 32635647

Article Published Date : Jul 04, 2020

Study Type : Human In Vitro

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Substances : Ginger

Pharmacological Actions : Neurogenesis, Wnt/β-catenin signaling pathway modulation

[+]

Light-emitting diodes have a potential to stimulate human dermal papilla cell proliferation.Nov 30, 2017

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Pubmed Data : Ann Dermatol. 2017 Dec ;29(6):747-754. Epub 2017 Oct 30. PMID: 29200764

Article Published Date : Nov 30, 2017

Study Type : Human In Vitro

Additional Links

Diseases : Hair Loss

Therapeutic Actions : Light-Emitting Diode Therapy

Pharmacological Actions : Wnt/β-catenin signaling pathway modulation

[+]

Resveratrol may represent a new interesting therapeutic approach, in order to affect glioma stem cell proliferation and motility.Dec 31, 2016

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Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

Oral curcumin intake could inhibit androgen receptor expression and probably PSA activity.Aug 31, 2015

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Pubmed Data : Exp Ther Med. 2021 Oct ;22(4):1119. Epub 2021 Aug 4. PMID: 34504573

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Pubmed Data : DNA Cell Biol. 2018 Oct 23. Epub 2018 Oct 23. PMID: 30351203

Article Published Date : Oct 22, 2018

Study Type : Animal Study

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Substances : Crocin

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Anti-metastatic, Wnt/β-catenin signaling pathway modulation

[+]

These results indicate that nutritional consumption of Hidrox can be considered as a new therapeutic approach for human fibromyalgia.Nov 12, 2021

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Pubmed Data : Invest New Drugs. 2019 May 17. Epub 2019 May 17. PMID: 31102118

Article Published Date : May 16, 2019

Study Type : Animal Study

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Substances : Cardamonin

Diseases : Gastric Cancer

Pharmacological Actions : Chemosensitizer, Wnt/β-catenin signaling pathway modulation

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil

[+]

Thymol isolated from Thymus vulgaris L. inhibits colorectal cancer cell growth and metastasis.Dec 31, 2019

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Pubmed Data : J Exp Clin Cancer Res. 2015 Jul 25 ;34:71. Epub 2015 Jul 25. PMID: 26205949

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Berberine protected C17.2 NSCs from oxidative damage then induced them to differentiate into neurons.Dec 31, 2018

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Pubmed Data : Front Cell Neurosci. 2019 ;13:395. Epub 2019 Sep 3. PMID: 31551713

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Brain: Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Wnt/β-catenin signaling pathway modulation

[+]

Beta-elemene increases chemosensitivity to 5-fluorouracil in colorectal carcinoma cells.Jul 31, 2018

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Pubmed Data : J Cell Biochem. 2018 Aug ;119(8):7032-7039. Epub 2018 May 8. PMID: 29737579

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Pubmed Data : J Surg Res. 2014 Dec ;192(2):298-304. Epub 2014 Jun 19. PMID: 25033705

Article Published Date : Nov 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Neurodegenerative Diseases

Pharmacological Actions : Neuroprotective Agents, Wnt/β-catenin signaling pathway modulation

[+]

Curcumin inhibits cell viability and increases apoptosis of SW620 human colon adenocarcinoma cells.Oct 03, 2019

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Pubmed Data : Med Sci Monit. 2019 Oct 4 ;25:7451-7458. Epub 2019 Oct 4. PMID: 31584928

Article Published Date : Oct 03, 2019

Study Type : In Vitro Study

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Substances : Curcumin

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin signaling pathway modulation

[+]

Dietary compound proanthocyanidins from Chinese bayberry leaves attenuate chemotherapy-resistant ovarian cancer stem cell traits.Jan 23, 2018

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Pubmed Data : Food Funct. 2018 Jan 24 ;9(1):525-533. PMID: 29256569

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Pubmed Data : Oncol Rep. 2020 Jan ;43(1):260-269. Epub 2019 Nov 19. PMID: 31746437

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

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Substances : Emodin

Diseases : Leukemia: Chronic myelogenous leukemia (CML)

Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin signaling pathway modulation

Additional Keywords : Natural Substance/Drug Synergy

[+]

Gambogic acid inhibits Wnt/β-catenin signaling and induces ER stress-mediated apoptosis in human cholangiocarcinoma.May 31, 2021

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Ginsenoside Rb1 facilitates browning by repressing Wnt/β-catenin signalling in 3T3-L1 adipocytes.Jan 26, 2021

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Pubmed Data : Med Sci Monit. 2021 Jan 27 ;27:e928619. Epub 2021 Jan 27. PMID: 33503016

Article Published Date : Jan 26, 2021

Study Type : In Vitro Study

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Substances : Ginsenosides

Diseases : Obesity

Pharmacological Actions : Wnt/β-catenin signaling pathway modulation

Additional Keywords : Anti-Obesity Agents

[+]

Ginsenoside Rh2 inhibits proliferation and migration of medulloblastoma Daoy by down-regulation of microRNA-31.Jul 31, 2018

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Pubmed Data : J Cell Biochem. 2018 Aug ;119(8):6527-6534. Epub 2018 Apr 19. PMID: 29377269

Article Published Date : Jul 31, 2018

Study Type : In Vitro Study

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Substances : Ginsenosides

Diseases : Medulloblastoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, MicroRNA modulator, Wnt/β-catenin signaling pathway modulation

[+]

Green tea polyphenols protect PC12 cells against H2O2-induced damages by upregulating lncRNA MALAT1.Dec 31, 2018

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Pubmed Data : PLoS One. 2021 ;16(3):e0247752. Epub 2021 Mar 4. PMID: 33661942

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Elecampane

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin signaling pathway modulation

[+]

Juglone can inhibit angiogenesis and metastasis in pancreatic cancer cells by targeting Wnt/β-catenin signaling.Dec 31, 2020

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Pubmed Data : Bratisl Lek Listy. 2021 ;122(2):132-137. PMID: 33502882

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

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Substances : Walnut

Diseases : Pancreatic Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative , Wnt/β-catenin signaling pathway modulation

[+]

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Pubmed Data : J Med Food. 2018 Jan ;21(1):57-69. Epub 2017 Oct 5. PMID: 28981378

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Noni

Diseases : Periodontal Diseases, Wound Healing: Periodontal

Pharmacological Actions : Regenerative, Wnt/β-catenin signaling pathway modulation

Additional Keywords : Bone Regeneration

[+]

Paeonol exerts anti‑tumor activity against colorectal cancer cells.Jul 31, 2020

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Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells.Jul 14, 2020

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Pubmed Data : J Gastrointest Cancer. 2019 Aug 29. Epub 2019 Aug 29. PMID: 31463888

Article Published Date : Aug 28, 2019

Study Type : In Vitro Study

Additional Links

Substances : Bitter Apple

Diseases : Colorectal Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Anti-metastatic, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Wnt/β-catenin signaling pathway modulation

[+]

The combination of Gelam honey and ginger may serve as a potential therapy in the treatment of colorectal cancer.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(15):6549-56. PMID: 26434873

[+]

Therapeutic effects of β-elemene via attenuation of the Wnt/β-catenin signaling pathway in cervical cancer cells.Feb 28, 2018

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Pubmed Data : Mol Med Rep. 2018 Mar ;17(3):4299-4306. Epub 2018 Jan 18. PMID: 29363722

Article Published Date : Feb 28, 2018

Study Type : In Vitro Study

Additional Links

Substances : Beta-Elemene

Diseases : Cervical Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Tumor Suppressor Protein p53 Upregulation, Wnt/β-catenin signaling pathway modulation

[+]

These findings demonstrate the effect of diosgenin on inhibiting the resilient breast cancer stem cells.Dec 31, 2016

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Pubmed Data : Front Pharmacol. 2017 ;8:124. Epub 2017 Mar 20. PMID: 28373842

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Pubmed Data : Future Oncol. 2013 Aug ;9(8):1097-103. PMID: 23902242

Article Published Date : Jul 31, 2013

Study Type : Review

Additional Links

Substances : Broccoli, Broccoli Sprouts, Sulforaphane

Diseases : Cancers: All

Pharmacological Actions : Anticarcinogenic Agents, NF-kappaB Inhibitor, Wnt/β-catenin signaling pathway modulation

Additional Keywords : Cancer Stem Cells, Isothiocyanates

[+]

This data showed a synergistic inhibitory effect of manuka honey on doxorubicin-mediated apoptotic cell death in liver cancer cells.May 27, 2021

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Pubmed Data : Biol Res. 2021 May 28 ;54(1):16. Epub 2021 May 28. PMID: 34049576

Article Published Date : May 27, 2021

Study Type : In Vitro Study

Additional Links

Substances : Honey

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic, Chemosensitizer, Wnt/β-catenin signaling pathway modulation

Additional Keywords : Drug: Doxorubicin

[+]

This is evidence of a causal relationship between vitamin D– vitamin D receptor signalling and melanoma survival.Nov 30, 2019

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Pubmed Data : Toxicol In Vitro. 2015 Aug ;29(5):1107-15. Epub 2015 Apr 21. PMID: 25910917

Article Published Date : Jul 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Urolithin A

Diseases : Liver Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiproliferative , Chemopreventive, Superoxide Dismutase Up-regulation, Tumor Suppressor Protein p53 Upregulation, Wnt/β-catenin signaling pathway modulation

[+]

Vicenin-2 inhibits Wnt/β-catenin signaling and induces apoptosis in HT-29 human colon cancer cell lineDec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2018 ;12:1303-1310. Epub 2018 May 18. PMID: 29849451

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin signaling pathway modulation

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View the Evidence: 168 Abstracts with Wnt/β-catenin signaling pathway modulation Research

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Indonesian ginger extract promotes neurogenesis of human neural stem cells.Jul 04, 2020

Light-emitting diodes have a potential to stimulate human dermal papilla cell proliferation.Nov 30, 2017

Resveratrol may represent a new interesting therapeutic approach, in order to affect glioma stem cell proliferation and motility.Dec 31, 2016

Resveratrol promotes axonal regeneration after spinal cord injury through activating Wnt/β-catenin signaling pathway.Oct 13, 2021

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

Arctigenin attenuates tumor metastasis of hepatocellular carcinoma.Dec 31, 2018

Artesunate inhibits intestinal tumorigenesis through Inhibiting Wnt signalling.Jul 24, 2020

Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy.Apr 23, 2020

Astragaloside IV alleviates puromycin aminonucleoside-induced podocyte cytoskeleton injury through the Wnt/PCP pathway.Dec 31, 2019

Benzyl isothiocyanate suppresses development and metastasis of murine mammary carcinoma by regulating the Wnt/β‑catenin pathway.Jul 31, 2019

Berberine combined with HMQ1611 exhibited potential antitumor activities against human liver cancer in vitro and in vivo.Dec 17, 2018

Betulinic acid attenuated bleomycin-induced pulmonary fibrosis by effectively intervening Wnt/β-catenin signaling.Dec 31, 2020

Caffeic acid phenethyl ester may be a potential therapeutic agent for patients with advanced PCa.May 14, 2016

Cinnamaldehyde enhances apoptotic effect of oxaliplatin and reverses epithelial-mesenchymal transition and stemnness in hypoxic colorectal cancer cells.Jul 11, 2019

Curcumin affects β-catenin pathway in HSCs and might suggest a possible new explanation for the effects of curcumin on HSC activation and liver fibrosis.Oct 31, 2014

Curcumin may be a potential therapeutic agent for the treatment of glucocorticoid induced osteoporosis.Dec 10, 2015

Curcumin nanoparticles may offer a therapeutic approach to treating neurodegenerative diseases by enhancing brain self-repair mechanisms.Jan 27, 2014

Curcumin provides neuroprotection against BPA-mediated impaired neurogenesis via activation of the Wnt/β-catenin signaling pathway.May 11, 2015

Curcumin reduces lung inflammation via Wnt/β-catenin signaling in mouse model of asthma.Apr 30, 2017

Effect of electroacupuncture at Wnt/β-catenin signaling pathway on inhibiting cartilage degeneration in rats with knee osteoarthritis.Oct 11, 2019

Ellagic acid may be used in functional foods or medicines to help treat nerve dysfunction, neurodegenerative disease and aging.Oct 28, 2016

Epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways.Aug 20, 2015

Eugenol emerges as an elixir by targeting β-catenin, the central cancer stem cell regulator in lung carcinogenesis.Feb 14, 2021

Gallic acid suppressed tumorigenesis by an LncRNA MALAT1-Wnt/β-catenin axis in hepatocellular carcinoma.Dec 31, 2020

Gastrodin treatment markedly preserved the Wnt/β-Catenin signalling pathway, which could promote neurogenesis and provide neuroprotection brain injury.May 31, 2019

Geraniol represents a valuable asset against colitis alone or in combination with the conventional anti-colitic therapies.Aug 31, 2015

Ginsenoside Rb1 ameliorates chronic kidney disease-associated vascular calcification by inhibiting the Wnt/β-catenin pathway.Aug 18, 2019

Ginsenoside Rg1 could exert its therapeutic effects on intestinal intestinal ischemia/reperfusion injury.Jan 01, 2016

Guava fruit extract and its triterpene constituents have osteoanabolic effect.Mar 07, 2017

Hawthorn polyphenol extract could be used as a functional food component in the adjuvant treatment of T2D.Mar 31, 2021

Hesperidin has a prophylactic effect against hepatocarcinogenesis.Jul 24, 2017

Intranasal administration of nasal gel huperzine A may represent a safe and noninvasive therapeutic strategy for the treatment of Alzheimer's disease.Mar 31, 2011

Isoliquiritigenin suppresses the proliferation and induced apoptosis via miR-32/LATS2/Wnt in nasopharyngeal carcinoma.Aug 04, 2019

Kaempferol stimulates WNT/β-catenin signaling pathway to induce differentiation of osteoblasts.Aug 30, 2019

Luteolin alleviates ischemia/reperfusion injury-induced no-reflow by regulating Wnt/β-catenin signaling.Oct 20, 2021

Micellar curcumin in combination with cisplatin can be a promising strategy for treatment of pediatric hepatocellular carcinoma.Oct 18, 2015

Oral curcumin intake could inhibit androgen receptor expression and probably PSA activity.Aug 31, 2015

Oridonin inhibits pancreatic cancer cell migration and epithelial-mesenchymal transition by suppressing Wnt/β-catenin signaling pathway.Dec 31, 2015

Panax notoginseng ameliorated albuminuria and podocyte epithelial-mesenchymal transition in diabetic rats.Dec 31, 2019

Quercetin improves blood-brain barrier dysfunction in rats with cerebral ischemia reperfusion via Wnt signaling pathway.Dec 31, 2018

Regulation of Wnt activity by curcumin is a feasible alternative strategy to rescue diabetic renal injury.Feb 29, 2016

Resveratrol and grape seed extract combination eliminates colon CSCs in vivo and in vitro.Dec 31, 2015

Resveratrol reduces the progression of titanium particle-induced osteolysis.Sep 30, 2021

Salvia miltiorrhiza protects against diabetic nephropathy.Nov 01, 2018

Sesamin promotes osteoblastic differentiation and protects rats from osteoporosis.Jul 16, 2019

These findings suggest crocin as a promising complementary antimetastatic herbal medicine for treatment of triple-negative breast cancer.Oct 22, 2018

These results indicate that nutritional consumption of Hidrox can be considered as a new therapeutic approach for human fibromyalgia.Nov 12, 2021

These results suggest that electro-acupuncture therapy may promote spinal cord recovery following injury.Jun 18, 2017

This study elucidates the mechanism by which crocin alleviates neuropathic pain.Dec 31, 2019

This study revealed that cotreatment of cardamonin and 5-FU could strongly potentiate the antitumor activity of 5-FU.May 16, 2019

Thymol isolated from Thymus vulgaris L. inhibits colorectal cancer cell growth and metastasis.Dec 31, 2019

Treadmill exercise alleviates Alzheimer disease-associated memory loss by increasing neurogenesis.Jul 31, 2016

Treatment with curcumin alleviates sublesional bone loss following spinal cord injury in rats.Aug 19, 2015

Vitamin D3 and 5-FU synergise together and exhibit better anticancer effects by modulating Wnt/β-catenin pathway.Jul 24, 2015

Xanthohumol protects against Azoxymethane-induced colorectal cancer.Nov 11, 2019

Oridonin inhibits growth and induces apoptosis of human neurocytoma cells via the Wnt/β-catenin pathway.Aug 31, 2018

1-Benzyl-indole-3-carbinol is a highly potent new small molecule inhibitor of Wnt/β-catenin signaling in melanoma cells.Jan 06, 2017

20(S)-ginsenoside Rh2 inhibits the proliferation and induces the apoptosis of KG-1a cells through the Wnt/β-catenin signaling pathway.Jun 30, 2016

A comparative study on anti-invasion, antimigration, and anti-adhesion effects of the bioactive carotenoids of saffron on 4T1 breast cancer cells.Jul 31, 2018

A review of targeting oncogenic transcription factors by polyphenols.Jan 03, 2018

A review of the possible use of Punica granatum in cancer therapy.May 01, 2018

A vanillin derivative suppresses the growth of HT29 cells through the Wnt/β-catenin signaling pathway.Jan 28, 2019

Acanthopanax senticosus polysaccharide suppressed the proliferation and metastasis of the human non-small cell lung cancer NCI-H520 cells.Jul 22, 2019

Activation of Wnt/β-catenin signaling is involved in hair growth-promoting effect of 655-nm red light and LED.Mar 31, 2018

Adenosine and cordycepin accelerate tissue remodeling process.May 24, 2021

Agaricus blazei extract (FA-2-b-β) induces apoptosis in chronic myeloid leukemia cells.Oct 31, 2020

An ellagic acid derivative efficiently inhibits colon cancer cell growth through a mechanism involving WNT16.Apr 30, 2015

Anthocyanins from Aronia melanocarpa Elliot induce apoptosis in Caco-2 cells.Oct 03, 2020

Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells.Oct 14, 2013

Apigenin was noted to upregulate miR-520b and miR-101 in different cancers to inhibit tumor growth. Oct 01, 2018

Atractylodes macrocephala can inhibit the proliferation and invasion of hepatocellular carcinoma cells.Oct 29, 2019

Baicalein may represent a potential candidate for periodontitis therapy.May 31, 2017

Wnt/β-catenin signaling pathway modulation

View the Evidence:
168 Abstracts with Wnt/β-catenin signaling pathway modulation Research