Wnt/β-catenin signaling pathway modulation

Name	AC	CK
Curcumin	19	27
Vitamin D	3	13
Resveratrol	5	12
Quercetin	10	11
Berberine	8	9
Ellagic Acid	7	9
Ginsenosides	8	9
Crocin	5	8
Flavonoids	7	8
Hawthorn	2	7
Ginger	2	6
Luteolin	5	6
EGCG (Epigallocatechin gallate)	4	5
Fenugreek	1	5
Ginkgo biloba	4	5
Mangiferin	3	5
Panax Notoginseng	3	5
Ursolic Acid	5	5
Astragaloside	2	4
Geraniol	2	4
Andrographolide	2	3
Apigenin	3	3
Benzyl isothiocyanate	2	3
Cardamonin	2	3
Cinnamaldehyde	2	3
Fisetin	2	3
Gallic Acid	2	3
Garlic	3	3
Gastrodin	2	3
Genistein	2	3
Leonurine	1	3
Melatonin	2	3
Nobiletin	3	3
Oridonin	2	3
Polyphenols	2	3
Sesamin	2	3
Sulforaphane	3	3
Theaflavins	2	3
Xanthohumol	2	3
Arctigenin	1	2
Artesunate	1	2
Baicalein	2	2
Bee Propolis	1	2
Beta-Elemene	2	2
Betulinic acid	1	2
Caffeic acid phenethyl ester	1	2
Cannabidiol	2	2
Carotenoids	1	2
Cyanidin	1	2
Delphinidin	2	2
Egg	1	2
Elecampane	2	2
Emodin	2	2
Eugenol	1	2
Grape Seed Extract	1	2
Guava	1	2
Hesperidin	1	2
Honey	2	2
Huperzine	1	2
Hydrogen: Molecular	1	2
Hydroxytyrosol	1	2
Isoliquiritigenin	1	2
Kaempferol	1	2
Mulberry	2	2
Piperine	2	2
Piperlongumine	2	2
Pomegranate	2	2
Pomegranate Seed	1	2
Puerarin	2	2
Reishi Mushroom	2	2
Rutin	2	2
Salvia miltiorrhiza	1	2
Sesamol	1	2
Thymol	1	2
Thymoquinone	1	2
Wogonin	2	2
4-Shogaol	1	1
6-Shogaol	1	1
Agaricus Blazei	1	1
Aloe Vera	1	1
Andrographis	1	1
Anthocyanins	1	1
Bai Zhu	1	1
Barberry	1	1
Berbamine	1	1
Bitter Apple	1	1
Bitter Melon	1	1
Broccoli	1	1
Broccoli Sprouts	1	1
Burdock	1	1
Caffeic Acid	1	1
Camptothecin	1	1
Capsaicin	1	1
Chlorophyllin	1	1
Chokeberry	1	1
Chrysin	1	1
Cordyceps Militaris	1	1
Coumestrol	1	1
Crocetin	1	1
Dandelion	1	1
Deguelin	1	1
Diosgenin	1	1
Dogwood	1	1
Echinacea	1	1
Frankincense	1	1
Gingerol	1	1
Ginseng (Korean)	1	1
Ginseng (Siberian)	1	1
Green Tea	1	1
Honeysuckle	1	1
Icariin	1	1
Indole-3-Carbinol	1	1
Kudzu	1	1
Lignans	1	1
Lupeol	1	1
Myricetin	1	1
Myrrh	1	1
Naringenin	1	1
Neem	1	1
Nicotinamide Mononucleotide	1	1
Noni	1	1
Oleanolic acid	1	1
Organosulfur Compounds	1	1
Paeonol	1	1
Parthenolide	1	1
Phenethyl isothiocyanate	1	1
Phyllanthus amarus	1	1
Piceatannol	1	1
Pistachio nut	1	1
Proanthocyanidins	1	1
Pterostilbene	1	1
Saffron	1	1
Silymarin	1	1
Sinomenine	1	1
Tanshinone IIA	1	1
Urolithin A	1	1
Vanillin	1	1
Walnut	1	1
Water: Deep Sea	1	1
Xanthones	1	1

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Resveratrol may represent a new interesting therapeutic approach, in order to affect glioma stem cell proliferation and motility.Dec 31, 2016

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Pubmed Data : J Adv Res. 2023 Jan ;43:219-231. Epub 2022 Mar 2. PMID: 36585110

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Carotenoids, Crocin

Diseases : Depression

Pharmacological Actions : Antidepressive Agents, Neurogenesis, Wnt/β-catenin signaling pathway modulation

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Arctigenin attenuates tumor metastasis of hepatocellular carcinoma.Dec 31, 2018

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Pubmed Data : Brain Res Bull. 2023 Aug 14 ;202:110734. Epub 2023 Aug 14. PMID: 37586426

Article Published Date : Aug 13, 2023

Study Type : Animal Study

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Diseases : Post-Traumatic Stress Disorders (PTSD)

Therapeutic Actions : Electroacupuncture

Pharmacological Actions : Neuroplasticity enhancement, Wnt/β-catenin signaling pathway modulation

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Ellagic acid inhibits dihydrotestosterone-induced ferroptosis and promotes hair regeneration by activating the wnt/β-catenin signaling pathway.Aug 09, 2024

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Pubmed Data : J Ethnopharmacol. 2024 Aug 10 ;330:118227. Epub 2024 Apr 27. PMID: 38685364

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Inhibition of oxidative stress, IL-13, and WNT/β-catenin in ovalbumin-sensitized rats by a novel organogel of Punica granatum seed oil saponifiable fraction.Sep 30, 2022

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Pubmed Data : Biomed Pharmacother. 2022 Oct ;154:113667. Epub 2022 Sep 7. PMID: 36942603

Article Published Date : Sep 30, 2022

Study Type : Animal Study

Additional Links

Substances : Pomegranate Seed

Diseases : Asthma: Bronchial, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, interleukin-13 down-regulation, Wnt/β-catenin signaling pathway modulation

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Intranasal administration of nasal gel huperzine A may represent a safe and noninvasive therapeutic strategy for the treatment of Alzheimer's disease.Mar 31, 2011

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Article Publish Status : This is a free article. Click here to read the complete article.

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Quercetin improves blood-brain barrier dysfunction in rats with cerebral ischemia reperfusion via Wnt signaling pathway.Dec 31, 2018

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Pubmed Data : Am J Transl Res. 2019 ;11(8):4683-4695. Epub 2019 Aug 15. PMID: 31497191

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Quercetin

Diseases : Cerebral Ischemia

Pharmacological Actions : Neuroprotective Agents, Wnt/β-catenin signaling pathway modulation

Additional Keywords : Blood Brain Barrier

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Regulation of Wnt activity by curcumin is a feasible alternative strategy to rescue diabetic renal injury.Feb 29, 2016

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Pubmed Data : J Exp Clin Cancer Res. 2015 Jul 25 ;34:71. Epub 2015 Jul 25. PMID: 26205949

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Benzyl isothiocyanate inhibits breast cancer cell tumorigenesisDec 31, 2014

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Pubmed Data : Front Cell Neurosci. 2019 ;13:395. Epub 2019 Sep 3. PMID: 31551713

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Brain: Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Wnt/β-catenin signaling pathway modulation

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Beta-elemene increases chemosensitivity to 5-fluorouracil in colorectal carcinoma cells.Jul 31, 2018

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Pubmed Data : J Cell Biochem. 2018 Aug ;119(8):7032-7039. Epub 2018 May 8. PMID: 29737579

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Pubmed Data : Phytomedicine. 2019 Jan ;52:117-128. Epub 2018 Sep 28. PMID: 30599890

Dietary compound proanthocyanidins from Chinese bayberry leaves attenuate chemotherapy-resistant ovarian cancer stem cell traits.Jan 23, 2018

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Pubmed Data : Food Funct. 2018 Jan 24 ;9(1):525-533. PMID: 29256569

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Pubmed Data : Interdiscip Sci. 2016 Aug 22. Epub 2016 Aug 22. PMID: 27549815

Article Published Date : Aug 21, 2016

Study Type : In Vitro Study

Additional Links

Substances : Reishi Mushroom

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative , Wnt/β-catenin signaling pathway modulation

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Ganoderma lucidum exerts an anticancer effect on human osteosarcoma cells.Dec 31, 2018

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Pubmed Data : IUBMB Life. 2021 Oct ;73(10):1222-1234. Epub 2021 Aug 4. PMID: 34273236

Article Published Date : Sep 30, 2021

Study Type : In Vitro Study

Additional Links

Substances : Ginkgo biloba

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative , Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Wnt/β-catenin signaling pathway modulation

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Ginsenoside Rb1 facilitates browning by repressing Wnt/β-catenin signalling in 3T3-L1 adipocytes.Jan 26, 2021

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Pubmed Data : Med Sci Monit. 2021 Jan 27 ;27:e928619. Epub 2021 Jan 27. PMID: 33503016

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Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2020 Apr ;45(8):1772-1778. PMID: 32489060

Article Published Date : Mar 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Wogonin

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Wnt/β-catenin signaling pathway modulation

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Pubmed Data : J Med Food. 2018 Jan ;21(1):57-69. Epub 2017 Oct 5. PMID: 28981378

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Pubmed Data : J Biol Chem. 2020 Mar 13 ;295(11):3576-3589. Epub 2020 Feb 6. PMID: 32029476

Article Published Date : Mar 12, 2020

Study Type : In Vitro Study

Additional Links

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Wnt/β-catenin signaling pathway modulation

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Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway.Nov 30, 2018

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Pubmed Data : Phytother Res. 2018 Dec ;32(12):2447-2455. Epub 2018 Aug 30. PMID: 30159926

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Pubmed Data : Sci Rep. 2021 Jan 13 ;11(1):1239. Epub 2021 Jan 13. PMID: 33441906

Article Published Date : Jan 12, 2021

Study Type : In Vitro Study

Additional Links

Diseases : Prostate Cancer

Pharmacological Actions : Chemopreventive, Wnt/β-catenin signaling pathway modulation

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Several pomegranate phytochemicals exhibited synergistic effects in suppressing growth of tumor cells.Dec 31, 2014

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Pubmed Data : J Neurochem. 2015 May 20. Epub 2015 May 20. PMID: 25991372

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Pubmed Data : Future Oncol. 2013 Aug ;9(8):1097-103. PMID: 23902242

Article Published Date : Jul 31, 2013

Study Type : Review

Additional Links

Substances : Broccoli, Broccoli Sprouts, Sulforaphane

Diseases : Cancers: All

Pharmacological Actions : Anticarcinogenic Agents, NF-kappaB Inhibitor, Wnt/β-catenin signaling pathway modulation

Additional Keywords : Cancer Stem Cells, Isothiocyanates

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This data showed a synergistic inhibitory effect of manuka honey on doxorubicin-mediated apoptotic cell death in liver cancer cells.May 27, 2021

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Pubmed Data : Biol Res. 2021 May 28 ;54(1):16. Epub 2021 May 28. PMID: 34049576

Article Published Date : May 27, 2021

Study Type : In Vitro Study

Additional Links

Substances : Honey

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic, Chemosensitizer, Wnt/β-catenin signaling pathway modulation

Additional Keywords : Drug: Doxorubicin

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This is evidence of a causal relationship between vitamin D– vitamin D receptor signalling and melanoma survival.Nov 30, 2019

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Pubmed Data : Int J Mol Sci. 2021 Nov 13 ;22(22). Epub 2021 Nov 13. PMID: 34830168

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Pubmed Data : Mol Clin Oncol. 2023 Oct ;19(4):77. Epub 2023 Aug 18. PMID: 37719039

Article Published Date : Sep 30, 2023

Study Type : In Vitro Study

Additional Links

Substances : Frankincense, Myrrh

Diseases : Liver Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Wnt/β-catenin signaling pathway modulation

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View the Evidence: 223 Abstracts with Wnt/β-catenin signaling pathway modulation Research

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The modulating effects of vitamin D on the activity of β-catenin in the endometrium of women with endometriosis.Feb 28, 2021

Ginsenoside Rh2 exhibits antiproliferative activity against non-small cell lung cancer cells.Apr 19, 2023

In vitro anti-cancer effect of Crataegus oxyacantha berry extract on hormone receptor positive and triple negative breast cancers.Mar 08, 2022

Indonesian ginger extract promotes neurogenesis of human neural stem cells.Jul 04, 2020

Light-emitting diodes have a potential to stimulate human dermal papilla cell proliferation.Nov 30, 2017

Resveratrol may represent a new interesting therapeutic approach, in order to affect glioma stem cell proliferation and motility.Dec 31, 2016

Trigonelline reverses high glucose-induced proliferation, fibrosis of mesangial cells via modulation of Wnt signaling pathway.Feb 08, 2022

Leonurine hydrochloride promotes osteogenic differentiation and increases osteoblastic bone formation in ovariectomized mice.Oct 11, 2018

Mangiferin alleviates 6-OHDA-induced Parkinson's disease.Jan 30, 2024

Resveratrol promotes axonal regeneration after spinal cord injury through activating Wnt/β-catenin signaling pathway.Oct 13, 2021

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

A natural carotenoid crocin exerts antidepressant action.Dec 31, 2022

Arctigenin attenuates tumor metastasis of hepatocellular carcinoma.Dec 31, 2018

Artesunate inhibits intestinal tumorigenesis through Inhibiting Wnt signalling.Jul 24, 2020

Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy.Apr 23, 2020

Astragaloside IV alleviates puromycin aminonucleoside-induced podocyte cytoskeleton injury through the Wnt/PCP pathway.Dec 31, 2019

Benzyl isothiocyanate suppresses development and metastasis of murine mammary carcinoma by regulating the Wnt/β‑catenin pathway.Jul 31, 2019

Berberine combined with HMQ1611 exhibited potential antitumor activities against human liver cancer in vitro and in vivo.Dec 17, 2018

Betulinic acid attenuated bleomycin-induced pulmonary fibrosis by effectively intervening Wnt/β-catenin signaling.Dec 31, 2020

Caffeic acid phenethyl ester may be a potential therapeutic agent for patients with advanced PCa.May 14, 2016

Cinnamaldehyde enhances apoptotic effect of oxaliplatin and reverses epithelial-mesenchymal transition and stemnness in hypoxic colorectal cancer cells.Jul 11, 2019

Curcumin affects β-catenin pathway in HSCs and might suggest a possible new explanation for the effects of curcumin on HSC activation and liver fibrosis.Oct 31, 2014

Curcumin may be a potential therapeutic agent for the treatment of glucocorticoid induced osteoporosis.Dec 10, 2015

Curcumin nanoparticles may offer a therapeutic approach to treating neurodegenerative diseases by enhancing brain self-repair mechanisms.Jan 27, 2014

Curcumin provides neuroprotection against BPA-mediated impaired neurogenesis via activation of the Wnt/β-catenin signaling pathway.May 11, 2015

Curcumin reduces lung inflammation via Wnt/β-catenin signaling in mouse model of asthma.Apr 30, 2017

Cyanidin improves spatial memory and cognition in bisphenol A-induced rat model of Alzheimer's-like neuropathology.May 02, 2024

Effect of electroacupuncture at Wnt/β-catenin signaling pathway on inhibiting cartilage degeneration in rats with knee osteoarthritis.Oct 11, 2019

Electroacupuncture alleviates PTSD-like behaviors by modulating hippocampal synaptic plasticity.Aug 13, 2023

Ellagic acid inhibits dihydrotestosterone-induced ferroptosis and promotes hair regeneration by activating the wnt/β-catenin signaling pathway.Aug 09, 2024

Ellagic acid may be used in functional foods or medicines to help treat nerve dysfunction, neurodegenerative disease and aging.Oct 28, 2016

Epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways.Aug 20, 2015

Eugenol emerges as an elixir by targeting β-catenin, the central cancer stem cell regulator in lung carcinogenesis.Feb 14, 2021

Gallic acid suppressed tumorigenesis by an LncRNA MALAT1-Wnt/β-catenin axis in hepatocellular carcinoma.Dec 31, 2020

Gastrodin treatment markedly preserved the Wnt/β-Catenin signalling pathway, which could promote neurogenesis and provide neuroprotection brain injury.May 31, 2019

Genistein ameliorated experimentally induced gastric ulcer.Nov 30, 2023

Geraniol protects against cyclosporine A-induced renal injury.Feb 14, 2022

Geraniol represents a valuable asset against colitis alone or in combination with the conventional anti-colitic therapies.Aug 31, 2015

Ginkgolide B promotes osteoblast differentiation via activation of canonical Wnt signalling and alleviates osteoporosis.Jul 31, 2019

Ginsenoside Rb1 ameliorates chronic kidney disease-associated vascular calcification by inhibiting the Wnt/β-catenin pathway.Aug 18, 2019

Ginsenoside Rg1 could exert its therapeutic effects on intestinal intestinal ischemia/reperfusion injury.Jan 01, 2016

Guava fruit extract and its triterpene constituents have osteoanabolic effect.Mar 07, 2017

Hawthorn polyphenol extract could be used as a functional food component in the adjuvant treatment of T2D.Mar 31, 2021

Hesperidin has a prophylactic effect against hepatocarcinogenesis.Jul 24, 2017

Hydrolyzed egg yolk peptide prevented osteoporosis by regulating Wnt/β-catenin signaling pathway.May 02, 2024

Inhibition of oxidative stress, IL-13, and WNT/β-catenin in ovalbumin-sensitized rats by a novel organogel of Punica granatum seed oil saponifiable fraction.Sep 30, 2022

Intranasal administration of nasal gel huperzine A may represent a safe and noninvasive therapeutic strategy for the treatment of Alzheimer's disease.Mar 31, 2011

Isoliquiritigenin suppresses the proliferation and induced apoptosis via miR-32/LATS2/Wnt in nasopharyngeal carcinoma.Aug 04, 2019

Kaempferol stimulates WNT/β-catenin signaling pathway to induce differentiation of osteoblasts.Aug 30, 2019

Low-level laser treatment stimulates hair growth via upregulating Wnt10b and β-catenin expression in C3H/HeJ mice.Jun 30, 2017

Luteolin alleviates ischemia/reperfusion injury-induced no-reflow by regulating Wnt/β-catenin signaling.Oct 20, 2021

Melatonin and andrographolide synergize to inhibit the colospheroid phenotype by targeting Wnt/beta-catenin signaling.May 25, 2022

Micellar curcumin in combination with cisplatin can be a promising strategy for treatment of pediatric hepatocellular carcinoma.Oct 18, 2015

Molecular hydrogen suppresses activated Wnt/β-catenin signaling.Aug 24, 2016

Network pharmacology identifies fisetin as a treatment for osteoporosis.Apr 21, 2023

Oral curcumin intake could inhibit androgen receptor expression and probably PSA activity.Aug 31, 2015

Oridonin inhibits pancreatic cancer cell migration and epithelial-mesenchymal transition by suppressing Wnt/β-catenin signaling pathway.Dec 31, 2015

Panax notoginseng ameliorated albuminuria and podocyte epithelial-mesenchymal transition in diabetic rats.Dec 31, 2019

Panax notoginseng saponins promote hair follicle growth.May 31, 2023

Quercetin improves blood-brain barrier dysfunction in rats with cerebral ischemia reperfusion via Wnt signaling pathway.Dec 31, 2018

Regulation of Wnt activity by curcumin is a feasible alternative strategy to rescue diabetic renal injury.Feb 29, 2016

Resveratrol and grape seed extract combination eliminates colon CSCs in vivo and in vitro.Dec 31, 2015

Resveratrol reduces the progression of titanium particle-induced osteolysis.Sep 30, 2021

Salvia miltiorrhiza protects against diabetic nephropathy.Nov 01, 2018

Scalp electroacupuncture promotes angiogenesis after stroke.Dec 31, 2021

Sesamin promotes osteoblastic differentiation and protects rats from osteoporosis.Jul 16, 2019

Sesamol inhibits proliferation, migration and invasion of triple negative breast cancer.Nov 30, 2022

Sinensetin protects against pulmonary fibrosis via inhibiting Wnt/β-Catenin signaling pathway.Sep 30, 2022

These findings suggest crocin as a promising complementary antimetastatic herbal medicine for treatment of triple-negative breast cancer.Oct 22, 2018

These results indicate that nutritional consumption of Hidrox can be considered as a new therapeutic approach for human fibromyalgia.Nov 12, 2021

These results suggest that electro-acupuncture therapy may promote spinal cord recovery following injury.Jun 18, 2017

This study elucidates the mechanism by which crocin alleviates neuropathic pain.Dec 31, 2019

Wnt/β-catenin signaling pathway modulation

View the Evidence:
223 Abstracts with Wnt/β-catenin signaling pathway modulation Research