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Found 18 results for "Diabetes"

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Abstracts (6)

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Genetic susceptibility to type 2 diabetes: Insights from a comprehensive meta-analysis of polymorphisms.

PURPOSE: To investigate the association between the FABP2 (rs1799883) polymorphism and the risk of developing type 2 diabetes mellitus (T2DM) across different populations and genetic models. Type 2 diabetes mellitus (T2DM) is a multicausal condition influenced by both hereditary and environmental determinants. The (rs1799883) polymorphism has been proposed as a potential hereditary risk factor due to its role in lipid metabolism, though previous findings across populations and genetic models remain inconsistent. METHODS: Studies sourced from PubMed, ScienceDirect, EMBASE, and other relevant databases up to June 1, 2025, were used to conduct the meta-analysis. Appropriate case-control studies examining the polymorphism and T2DM were analyzed under four genetic models. Subgroup analysis by ethnicity, in silico functional predictions (SIFT, PolyPhen-2), and power analysis were also performed. RESULTS: A total of 26 studies, including 6032 T2DM patients and 8907 controls, were analyzed. The Ala54Thr variant showed no significant association with T2DM under the allele, dominant, or overdominant models. However, a strong association was identified within the recessive model (AA vs. AT + TT; OR = 4.11, 95% CI: 2.96-5.71,  < 0.00001). Subgroup analysis revealed significant associations in Asian and Caucasian populations, while a protective effect was noted in other ethnic groups. In silico predictions indicated the variant is functionally tolerated and benign. The analysis had a high statistical power (99%). CONCLUSION: The Ala54Thr polymorphism of the gene is significantly associated with higher T2DM risk under a recessive model, notably in Asian and Caucasian populations. These findings support its potential utility as a genetic marker in risk assessment and highlight the importance of ethnicity-specific analysis in understanding T2DM susceptibility.

Anilkumar AS, Thomas SM, Veerabathiran R, Journal of diabetes and metabolic disorders

Cord blood cardiac markers and tissue doppler echocardiography findings in infants of diabetic mothers.

BACKGROUND: Maternal diabetes mellitus (DM) significantly affects fetal cardiac and placental structure and function. This study aimed to assess structural and functional cardiac changes in infants of diabetic mothers (IDMs) using echocardiographic data and cord blood cardiac biomarkers. METHODS: M-mode and pulsed-wave tissue Doppler imaging (PW-TDI) echocardiography along with cord blood cardiac markers were evaluated in 40 IDMs and 40 healthy term newborns. Cardiac biomarkers included troponin T (Trop-T), N-terminal pro-brain natriuretic peptide (NT-proBNP), and ischemia-modified albumin (IMA). RESULTS: Among the diabetic mothers, 87.5% had gestational diabetes mellitus (GDM) and 12.5% had type 1 diabetes mellitus (T1DM). Interventricular septum (IVS) thickness was significantly greater in the IDM group. Of the IDMs, 32.5% had asymmetric septal hypertrophy. Mid-septal tissue Doppler Imaging (TDI) parameters showed significantly altered velocities and time intervals. NT-proBNP and IMA levels were significantly elevated in the IDMs group, while Trop-T was not statistically different. No correlation was found between TDI parameters and biomarker levels. CONCLUSION: Cardiac dysfunction and elevated cord blood biomarkers in IDMs reflect subclinical stress. These findings support the utility of TDI and biochemical markers for early cardiac assessment in IDMs. Larger studies are needed to validate the use of these markers for routine screening and to better understand their pathophysiological significance.

Taşkın SN, Doğan V, Acungil ZK, Cinni RG, Bilge S, Gök ŞÜ, Aydoğan L, Benli İ, Kara AE, İnce DA, Yılmaz R, Italian journal of pediatrics

Insulin resistance and serum adiponectin levels in Nigerian patients with type 2 diabetes mellitus: a case-control study.

OBJECTIVE: The study examined the association between adiponectin levels and markers of Insulin Resistance (IR) in obese and non-obese adults with type 2 diabetes. Insulin Resistance was estimated using HOMA-IR, while group differences were assessed using appropriate statistical tests. Multiple linear regression was applied to evaluate associations between adiponectin and obesity indices while adjusting for HOMA-IR. RESULTS: Mean serum adiponectin did not differ significantly across obese diabetics, non-obese diabetics, and controls (5.9 ± 3.6 µg/mL, 6.4 ± 3.2 µg/mL, and 6.8 ± 3.5 µg/mL, respectively; p = 0.13). Mean HOMA-IR values were comparable among obese diabetics (1.4 ± 2.1), non-obese diabetics (1.3 ± 1.0), and controls (1.1 ± 0.6). In multivariable regression models, serum adiponectin was not independently associated with obesity indices or HOMA-IR (all p > 0.05). Serum adiponectin levels were not significantly different across the study groups, although numerically lower values were observed in obese individuals with diabetes. No significant relationship was found between adiponectin and clinical or biochemical markers of IR. These findings suggest that adiponectin may have limited utility as an isolated marker of IR in Nigerian adults with type 2 diabetes and underscore the need for larger, longitudinal studies to clarify its role.

Ezekpo OO, Adetunji TA, Soyoye DO, Ajani GO, Olopade OB, Ogunniyi OA, Lamidi A, Ikem RT, Kolawole BA, BMC research notes

Cultural recognition for women with diabetes using alternative health care in Malay Ethnic, West Kalimantan, Indonesia: A focused ethnography.

BACKGROUND: The use of alternative health care among people with diabetes remains widespread, especially in rural areas of West Kalimantan, Indonesia. In the Malay ethnic community, alternative health care is not just an issue of access but also deeply rooted in cultural and spiritual practices. However, limited research has explored the symbolic meanings and socio-cultural dynamics that underlie the consistent use of alternative health care by people with diabetes. OBJECTIVE: This study aimed to explore the cultural recognition and socio-cultural meanings embedded in the use of AHC among Malays with diabetes in West Kalimantan, Indonesia. METHODS: A focused ethnography was conducted from July to November 2024 using in-depth interviews, focus group discussions (FGDs), observations, and field notes. A total of 45 participants took part in interviews, including people with diabetes, healthcare providers, traditional healers (Tabib), family members, healthcare volunteers, and community leaders. FGDs comprised five groups, and observations included nine participants. Data were analyzed through content, typology, and matrix analysis. To ensure trustworthiness, triangulation and member checking were employed. The study was guided by three theoretical frameworks: Symbolic Interactionism, Cultural Theory, and Critical Social Theory. FINDINGS: Four main themes emerged: (1) cultural logic and illness meaning, in which illness was viewed as a spiritual and moral imbalance; (2) symbolic meanings in alternative health care practices, highlighting ritual healing and spiritual faith; (3) social structures as pillars of healing, where family and community roles legitimized alternative health care; and (4) social processes that created cultural recognition through intergenerational transmission and community validation. CONCLUSION: Recognizing AHC culturally is essential for understanding the illness experiences of people with diabetes. For nursing practice, these findings emphasize the importance of providing culturally respectful care, fostering open communication between healthcare providers and people with diabetes, and incorporating alternative healthcare approaches into safe, evidence-based health education.

Parliani, Pearkao C, Belitung nursing journal

Association between socioeconomic status and diabetic retinopathy in individuals with type 1 diabetes: a systematic review and meta-analysis.

BACKGROUND: Despite improvements in screening and diabetes management, diabetic retinopathy (DR) remains a leading cause of vision loss in individuals with type 1 diabetes (T1D). Although clinical risk factors for DR are well established, the impact of socioeconomic status (SES) on DR risk remains poorly defined. The objective of this study was to estimate the association between SES and DR in people with T1D. METHODS: We searched MEDLINE, Scopus, and Web of Science from inception to May 2025 for observational studies evaluating the association between SES and DR prevalence or incidence in individuals with T1D. Two reviewers independently performed study selection, data extraction, and risk of bias assessment using the ROBINS-E tool. Random-effects meta-analyses were conducted using the Sidik-Jonkman method. Subgroup analyses were performed by DR severity, SES measurement level, geographic region, and study design. Certainty was graded using the GRADE framework. RESULTS: Twenty-two studies including 69,446 individuals from 13 countries were included. Low SES was significantly associated with higher DR risk (OR = 1.44; 95% CI: 1.21-1.71; I = 75%). The association was stronger for proliferative or vision-threatening DR (OR = 1.55; 95% CI: 1.19-2.04; I = 49.3%). Subgroup analyses confirmed consistent associations across study designs, SES definitions, and regions. Sensitivity analyses and trim-and-fill adjustments yielded similar results. CONCLUSIONS: Socioeconomic disadvantage is a significant and clinically relevant risk factor for DR in individuals with T1D. The effect appears more pronounced for advanced stages. Integrating SES into DR risk stratification models and screening strategies may be essential to promote equity and reduce preventable vision loss. PROSPERO REGISTRATION: CRD420251034446.

Sebastian-Valles F, de Arenas-Arroyo SN, Simó-Servat O, Simó R, Painter H, Arranz Martín JA, Navas-Moreno V, Marazuela M, Martínez-Vizcaíno V, Martínez-Alfonso J, BMC medicine

Videos (6)

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5 Steps to Reverse Diabetes
Video Feed Feb 4, 2014

5 Steps to Reverse Diabetes

Does diabetes mean drugs? Not necessarily! In this week's UltraWellness blog, Dr. Mark Hyman brings you the last installment of his two-part discussion on diabetes. You'll learn why medications aren't...

153 views
Eating Fat Doesn't Make You Fat (Infographic)
Video Feed May 18, 2014

Eating Fat Doesn't Make You Fat (Infographic)

"The low-fat, high-carb diet did not lead to a decline in weight and heart disease. Instead we saw a rise in obesity and diabetes." This infographic explains why it's carbs, not fat that makes us fat…...

146 views
Man Heals Cancer with Diet, Gets off 25 Medications
Video Feed May 25, 2013

Man Heals Cancer with Diet, Gets off 25 Medications

Dave "the Raw Food Trucker" describes how he was able to get of diabetes meds in days and cure his colon cancer within six months when fellow truck drivers teach him how to eat a diet of raw foods and...

122 views
Turmeric Curcumin for Prediabetes
Video Feed Feb 2, 2016

Turmeric Curcumin for Prediabetes

A randomized, double-blinded, placebo-controlled trial on the use of the turmeric pigment curcumin to prevent diabetes in prediabetics is published with extraordinary results. The post Turmeric Curcum...

88 views

Health Guides (1)

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.