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Found 18 results for "Ginger"
Articles (6)
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Aug 11, 2013
GI Ginger
Ginger,” since ginger is known to soothe and relax the gastrointestinal (GI) tract, but that
jordanrubin
3 min
Dec 10, 2012
Ginger Relieves Muscle Pain from Your Workout
ginger ale for an upset stomach. It makes sense because for thousands of years, ginger
mmking
3 min
Jul 07, 2024
Can Ginger Beat Out The Multi-Billion Dollar Acid Blockers?
ginger plant in relieving symptoms of indigestion and heartburn? Ginger is a spice, a food
Sayer Ji
4 min
Oct 25, 2012
Ginger's Many Evidence-Based Health Benefits Revealed
ginger a culinary marvel, its health benefits are stunning. It has been shown to be more
GaiaHealth
11 min
Oct 11, 2012
Herbs from India’s Tribal Pouch: Ginger
Ginger ( Zingiber officinale Rosc.) is the member of family Zingiberaceae, locally known as Adrak or Ada in India
deepakacharya
4 minAbstracts (6)
View allGinger extract release from 3D printed calcium phosphate scaffolds for bone regeneration.
The development of multifunctional bone scaffolds that promote early osteogenesis and angiogenesis is a promising strategy for treating critical-sized bone defects. In this study, 3D-printed tricalcium phosphate (3DP TCP) scaffolds were loaded with ginger extract, a natural compound with known anti-inflammatory and regenerative properties. In vitro release study shows sustained ginger extract release over 28 days, with accelerated release under acidic conditions. Ginger extract enhanced osteoblast viability (1.3-fold at day 11), upregulates osteogenic genes including BGLAP (6.3-fold), RUNX2 (4.9-fold), and ALPL (8.1-fold), while supresses osteoclast activity by downregulating RANKL (up to 11-fold). TRAP assay, resorption pit analysis, and actin ring staining confirm reduced osteoclastogenesis. Angiogenesis study showed a 7.5-fold increase in endothelial tube formation and a 19 % enhancement in vitro wound healing. In vivo, ginger extract-loaded scaffolds implanted in rat distal femur defects shows increase in new bone formation, with SRBS staining showing 38.1 % bone area compared to 19.3 % in control, and Masson-Goldner staining showing 43.3 % mineralized bone area versus 25.9 % in control. These results underscore the potential of ginger extract-loaded 3DP TCP scaffolds as a bioactive platform for enhancing bone regeneration through osteoinduction, anti-resorptive effects, and angiogenesis.
Bose S, Jo Y, Dahiya A, Biomaterials advances
The effect of endurance training with Maca or ginger on steroidogenesis and antioxidant status of testicular tissue in male rats.
Today's primary approach to enhancing reproductive function involves lifestyle modifications, dietary adjustments, the use of herbal supplements, and regular exercise. In this study, we tried to show that the use of ginger or Maca supplements along with endurance training can affect reproductive function indicators, including spermatogenesis and steroidogenesis in testicular tissue. Adult male Wistar rats (n = 42, weight: 220 ± 20 g, age: 10-12 weeks) were randomly divided into six equal groups. The groups included control, ginger (100 mg/kg body weight), Maca (100 mg/kg body weight), endurance training (ET), ET + ginger and ET + Maca. Tissue levels of testosterone were measured along with the expression of genes involved in steroidogenesis (P450Scc, P450c17, HSD17β3, and P450 aromatase) and genes involved in its regulation (LHR, FSHR, GR, and SGP-1). Spermatogenesis was assessed by counting the number of spermatogenic cells (spermatogonia and spermatocytes), Leydig and Sertoli cells, and characteristics of the seminiferous tubules. Testicular levels of GPx, MDA, and TAC were evaluated. The gene expression of P450Scc and P450c17 were upregulated in the ginger (P = 0.03) (P = 0.03), endurance training (P = 0.02) (P = 0.003) and endurance training + ginger (P = 0.01) (P = 0.001) groups compared to the control group, respectively. The testicular expression of P450 aromatase gene increased in the endurance training (P = 0.007) and the endurance training + ginger (P = 0.049) groups compared to the control group. The results of P450Scc gene expression was upregulated in the endurance training (P = 0.001) and endurance training + Maca (P = 0.01) groups compared to the control group. Also, the expression of P450c17 was increased in the endurance training (P = 0.0005) and endurance training + Maca (P = 0.0014) groups compared to the control group. No significant difference was observed in the testicular expression of genes involved in the regulation of spermatogenesis (LHR, FSHR, and SGP-1) among all groups. The results indicated that the GR gene was up-regulated in the endurance training + ginger group compared to the ginger (P = 0.03) and endurance training group (P = 0.04). The level of TAC as oxidative parameter was increased in the endurance training + Maca group compared to the control (P = 0.0182), the Maca (P = 0.0008), and the endurance training (P = 0.02) groups. The level of MDA was decreased in endurance training + ginger group compared to the ginger (P = 0.01) and endurance training (P = 0.01) groups. The GPx activity indicated a protective effect and improved oxidative status in testicular tissue in the Maca, the ginger and the endurance training groups. Consistent with our steroidogenesis results, spermatogenesis parameters were significantly increased by Maca, ginger, endurance training, and their combination with endurance training compared to the control group (P < 0.05). It can be concluded that consuming ginger or Maca along with endurance training can strengthen the antioxidant system in testicular tissue and enhance steroidogenesis and spermatogenesis.
Alsamawi SAA, Nasiri K, Akbari A, Fathi R, The Journal of steroid biochemistry and molecular biology
Ohmic heating-assisted extraction of ginger bioactives: Synergistic impacts on extract composition and on the quality of high-protein milk beverages.
Leveraging the potential of ohmic heating (OH) for phytochemical extraction, this study evaluated how different electric field strengths influence the extraction of ginger bioactives and the subsequent quality of a lemon-flavored high-protein milk beverage. OH markedly improved thermal efficiency. at 140 V (25.45 V/cm) the extract reached 80 °C with an 87.7% reduction in heating time compared with the conventional method. Extracts obtained at 100 V (18.18 V/cm) and 140 V exhibited ∼44-45% DPPH radical-scavenging activity, outperforming the control and showing activity comparable to the conventionally heated extract. Although total phenolic content did not increase under OH, beverages fortified with OH extracts displayed superior antioxidant stability during storage, maintaining higher activity than other treatments from day 7 to day 21. OH also produced a distinct volatile profile compared with conventional heating, suggesting enhanced release of aroma-active compounds. When incorporated into the dairy matrix, OH extracts significantly affected beverage rheology, increasing the consistency index (up to 0.10 Pa·sⁿ) and apparent viscosity (up to 45 mPa·s) compared with beverages containing conventional or control extracts (29-31 mPa·s). The dynamic sensory profile revealed that OH beverages were more frequently associated with "lemon flavor," "sweet taste," and "creamy/viscous texture," consistent with instrumental measurements. Consumer acceptance remained high for all OH formulations and was accompanied by more positive emotional responses - particularly "happy/satisfied" and "relaxed/calm" -whereas the conventionally heated extract elicited less favorable associations. Overall, the findings demonstrate that OH, particularly at higher electric field strengths, is an efficient and advantageous technique for extracting ginger bioactives and enhancing the physicochemical, functional, and sensory quality of high-protein milk beverages. The technology shows strong potential for the development of novel functional products with improved stability and consumer appeal.
Vieira GP, Martins CPC, Pereira TRC, Cipriano LC, Goulart MB, Guimarães JT, Pagani MM, Duarte MCKH, Cruz AG, Mano SB, Mársico ET, Esmerino EA, Food research international (Ottawa, Ont.)
Ginger (Zingiber officinale Roscoe)-derived natural compounds inhibit vitamin K-dependent carboxylation: a novel possibility for traditional Chinese medicine-induced bleeding risk.
BACKGROUND: While bleeding associated with anticoagulants is often predictable and manageable, non-anticoagulant induced bleeding poses greater clinical challenges due to unclear mechanisms. These disorders primarily arise from coagulation factor dysfunction, with emerging evidence implicating off-target disruption of the vitamin K cycle. However, existing research on Traditional Chinese Medicines (TCMs) has largely focused on their antiplatelet effects and direct inhibition of coagulation proteases. Given the complex, multi-component nature of TCMs, a comprehensive evaluation of their potential to interfere with vitamin K cycle remains critically needed. PURPOSE: This study aims to systematically investigate TCM-derived compounds that interfere with the vitamin K cycle, thereby elucidating novel mechanisms underlying TCM-induced coagulopathy and informing their safety assessment. STUDY DESIGN: A high-throughput vitamin K-dependent (VKD) carboxylation assay was employed to screen 1931 pharmacologically characterized bioactive compounds derived from TCMs. Lead candidates were further validated through in vivo mouse experiments. METHODS: The VKD carboxylation assay quantified compound-induced inhibition of γ-carboxylation. Positive hits were evaluated for dose-dependent effects, and mechanism of potential inhibitors were investigated using vitamin K recue assay and molecular docking analysis. Their anticoagulant activity was validated in vivo in mice following oral administration. RESULTS: Screening identified two ginger (Zingiber officinale Roscoe)-derived compounds-6-paradol and 10-gingerol-as first-in-class natural vitamin K antagonists that inhibited γ-carboxylation in a dose-dependent manner. Vitamin K rescue assays and molecular docking analyses demonstrated that both compounds directly target vitamin K epoxide reductase (VKOR), thereby disrupting the vitamin K cycle. Oral administration in mice significantly prolonged prothrombin and tail bleeding times, confirming their anticoagulant effects. CONCLUSION: Our study establishes 6-paradol and 10-gingerol, derived from ginger, as the first natural inhibitors of VKOR. This finding provides a novel mechanistic basis for understanding bleeding risks associated with TCMs, thereby highlighting the "double-edged sword" nature of their bioactive components. Consequently, this study underscores the critical need to balance the exploration of TCM's therapeutic potential with rigorous safety assessments, including the specific evaluation of VKOR inhibition.
Yang H, Xu Y, Feng Y, Ling H, Liu Z, Ma Y, Chen X, Ge S, Ye H, Phytomedicine : international journal of phytotherapy and phytopharmacology
Insights Into the Mechanism of Treatment of Ulcerative Colitis With Preprocessed and Postprocessed Dried Ginger by Integrating Serum Pharmacochemistry With Network Pharmacology and Harmacological Validation.
Serum pharmacochemistry was applied to identify the blood-absorbed constituents of dry ginger (DG) and processed ginger (PG). Network pharmacology was employed to construct compound-target-pathway interaction networks, which were further validated through molecular docking to assess the binding affinities between ligands and key targets. Furthermore, a dextran sulfate sodium (DSS)-induced murine model of ulcerative colitis (UC) was established to systematically investigate the multi-target regulatory mechanisms of DG and PG. The processing of DG transforms gingerols into shogaols, thereby modifying its bioactive composition and physiological functions. DG, which is rich in 6-gingerol, mitigates intestinal inflammation through the inhibition of the PI3K-Akt signaling pathway, whereas PG increases the levels of shogaols and zingerone, promoting gut barrier restoration and reducing occult bleeding. Our findings illustrate how processing alters the functional properties of ginger, offering valuable insights for the development of ginger-derived products tailored to specific gastrointestinal health benefits.
Han S, Yang X, Du J, Hou Z, Wei W, Li J, Yong X, Xu H, Biomedical chromatography : BMC
Videos (6)
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May 13, 2014
10 Natural Ways to Boost Your Immune System
Here are 10 simple things you can do to naturally boost your immune system and health… See related research on ginger The post 10 Natural Ways to Boost Your Immune System appeared first on GreenMedTV.
955 views
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Feb 3, 2014
Detox Turmeric Tea
A simple and easy to make detox tea… Ingredients: 3 heaped teaspoons turmeric 1 heaped teaspoon ground cloves 2 teaspoons ground cardamon 2 teaspoons ground ginger 1.5 Lts of 3.5 pints of filtered wat...
291 views
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Feb 2, 2016
Fennel Seeds for Menstrual Cramps and PMS
Fennel seeds can work as drugs like ibuprofen for painful periods, and an eighth of a teaspoon of ginger powder three times a day can cut menstrual bleeding in half. The post Fennel Seeds for Menstrua...
253 views
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May 13, 2014
10 Powerful Health Benefits of Ginger
There are numerous health benefits of ginger. It contains powerful healing properties. This handy infographic breaks them down… See related research on ginger The post 10 Powerful Health Benefits of G...
246 views
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Jan 12, 2014
The Most Anti-Inflammatory Spices
An elegant experiment is described in which the blood of those eating different types of spices such as cloves, ginger, rosemary, and turmeric is tested for anti-inflammatory capacity.
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