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Found 18 results for "Vitamin D"
Articles (6)
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Jun 10, 2012
Vitamin D: How Much, And What Are Its Benefits?
vitamin D supplements were very likely to be vitamin D deficient [7]. As vitamin D
OrthomolecularNewsService
11 min
Jul 19, 2023
Place Mushrooms in Sunlight to Get Your Vitamin D
Vitamin D is an essential vitamin that boosts the immune system and plays vital roles
paulstamets
9 min
Jul 08, 2019
Vitamins Against Viruses
Implausible Pro-Vaccine Publications Contrasted Against Ignored Public Health Campaigns and Double-Blind Placebo-Controlled
alexvasquez
36 min
Mar 11, 2022
It's Official: Vitamin D Reduces the Incidence of Autoimmunity
And a brief review of the growing body of knowledge of vitamin D
OrthomolecularNewsService
11 minAbstracts (6)
View allEngineered CdS@ZIF67 nanozyme-assisted detection of vitamin D deficiency.
Peroxidases are natural enzymes commonly employed in developing sensitive immunoassays; however, their limited stability has sparked growing interest in enzyme-mimics. Zeolitic imidazolate frameworks (ZIFs), a subclass of metal-organic frameworks (MOFs), are promising alternatives due to their ease of synthesis, tunable porosity, multiple active sites, and robust catalytic properties. In the current work, we synthesized and characterized CdS@ZIF67, which is a nanocomposite of CdS quantum dots and ZIF-67, exhibiting peroxidase-like activity. Catalytic performance was then examined using Michaelis-Menten kinetics, with estimated key parameters (k, K, and catalytic efficiency k/K) benchmarked against natural Horseradish Peroxidase (HRP) enzyme. It showed an increase in catalytic efficiency of the order 10 as compared to ZIF 67, and a comparable catalytic efficiency with that of HRP. To demonstrate its biosensing ability, we further conjugated it to anti-vitamin D3 antibodies and implemented this for sensing vitamin D3 molecules in a competitive dipstick format. Here, the nanozymes catalyzed a clear colorimetric response for clinically relevant concentrations of vitamin D3 in the presence of TMB and HO, with a limit of detection (LOD) of 26.98 ng/ml, and a LOD of 24.93 ng/ml in spiked serum samples. Our assays could reliably distinguish between deficiency and sufficiency of vitamin D3. This study provides valuable insights into nanozyme design and mimetic function, emphasizing the promising role of CdS@ZIF67 nanozymes as substitutes for natural enzymes in biosensing applications.
Anandita A, Rath D, Singh P, Pathak PK, Salunkhe RR, Biosensors & bioelectronics
Coffee consumption and its association with vitamin D level, lifestyle factors, and mental health symptoms among adults in Saudi Arabia.
Coffee is widely consumed in Saudi Arabia, but its relationship with vitamin D status and related health indicators remains unclear. This cross-sectional study examined associations between coffee consumption, serum 25-hydroxyvitamin D [25(OH)D], lifestyle factors, and mental health symptoms in 387 adults aged 20-60 years recruited in Saudi Arabia (February-March 2024). Participants were classified as normal (≤3 cups/day) or high (>3 cups/day) coffee consumers. Anthropometric measures and serum 25(OH)D and parathyroid hormone were obtained from medical records, and diet, physical activity, sun exposure, and mental health symptoms were assessed by questionnaire. Associations were examined using group comparisons and multivariable regression models. Compared with normal coffee consumers, high coffee consumers had higher BMI (p = 0.043) and lower serum 25(OH)D (p = 0.05). In multivariable linear regression, higher caffeine intake was associated with lower serum 25(OH)D (β = -0.04 nmol/L per mg/day; 95 % CI -0.055 to -0.027; p < 0.001). In logistic regression, higher caffeine intake was associated with lower odds of vitamin D deficiency (<30 nmol/L) (OR = 0.98 per mg/day; 95 % CI 0.97-0.99; p < 0.001). High coffee consumers more frequently reported sleep disturbance/insomnia (49.1 % vs 34.2 %), sweating (20.8 % vs 9.6 %), and raised heart rate (27.7 % vs 17.2 %) (all p < 0.01), whereas headache, irritability, anxiety, and depression did not differ between groups. In this sample of Saudi adults, higher coffee intake was associated with lower 25(OH)D, higher BMI, and more arousal-related symptoms. These observational findings warrant confirmation in longitudinal or interventional studies to clarify temporality and inform public health strategies.
Hakim NA, The Journal of steroid biochemistry and molecular biology
Vitamin D metabolite ratio as a marker of nutritional bone health in adolescents.
Vitamin D deficiency is a widespread public health issue among Saudi adolescents, posing significant risks to bone health and long-term well-being. Traditional markers such as serum 25-hydroxyvitamin D [25(OH)D] may not fully capture functional vitamin D status, particularly during critical growth periods such as adolescence. This study aimed to evaluate vitamin D metabolite levels and their association with calcium intake and bone health markers in Saudi adolescents, with a focus on the vitamin D metabolite ratio (VMR) as a potential indicator of functional vitamin D sufficiency. A cross-sectional analysis was conducted involving 949 (54 % females) Saudi adolescents. Serum levels of vitamin D metabolites, including 25(OH)D; 24,25-dihydroxyvitamin D [24,25(OH)₂D], and 25(OH)D₂, were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). VMR was calculated as the ratio of 24,25(OH)₂D to 25(OH)D. Dietary calcium intake was assessed via validated questionnaires. Parathyroid hormone (PTH) and serum calcium levels were analyzed in a subset of participants. Vitamin D deficiency was highly prevalent, with 86.5 % of participants showing insufficient 25(OH)D levels. Over 93 % had low 24,25(OH)₂D, 99.7 % had undetectable 25(OH)D₂, and 74.9 % exhibited low VMR. VMR was significantly associated with serum and dietary calcium intake among girls, but not boys, suggesting potential sex-specific metabolic differences. Additionally, only VMR showed a significant association with serum calcium. An inverse association between PTH and both total vitamin D (r = -0.28, p < 0.05) and serum calcium (r = -0.34, p < 0.01) was observed in the subset analysis. In conclusion, VMR may serve as a useful sex-specific biomarker of functional vitamin D status in adolescents. The findings highlight the importance of addressing both intake and metabolic processing of vitamin D to optimize bone health during adolescence.
Al-Daghri NM, Alenad AM, Sabico S, Wani K, Al-Saleh Y, Khattak MNK, Alnaami AM, Fakhurji LT, Alokail MS, Reginster JY, Cavalier E, The Journal of steroid biochemistry and molecular biology
Effects of vitamin D intake alone on elderly body composition: A systematic review and meta-analysis of RCTs.
BACKGROUND: This study investigated the effect of vitamin D on body composition in individuals aged 60 years and older. METHODS: PubMed, Embase, and Cochrane databases were searched from inception to April 22, 2024, for randomized controlled trials reporting skeletal muscle mass index (SMI), lean mass (LM), handgrip strength, and fat mass (FM) as primary or secondary outcomes in elderly individuals with a mean age of 60 years or older were included. The primary outcome was the change in SMI between vitamin D and control groups; secondary outcomes were changes in LM, FM, and handgrip strength. RESULTS: Seven randomized controlled trials met eligibility criteria. Mean age ranged from 60 to 74 years, participants ranged from 50 to 1094, and study durations ranged from 3 to 36 months. The mean baseline 25(OH)D concentration ranged from 15.1 to 33.0 ng/mL. The vitamin D intake group was not associated with an increase in SMI, LM, or handgrip strength compared to the control group, although a decrease in FM was observed. In the meta-analysis excluding studies that used active vitamin D, the vitamin D intake group was not associated with increases in SMI, LM, or handgrip strength, nor with a decrease in FM compared to the control group. CONCLUSION: In the present study, vitamin D intake did not increase SMI, LM, or handgrip strength in the elderly individuals, although a possible decrease in FM was observed. Further studies are needed to better elucidate the effects of vitamin D on body composition in the elderly.
Matsuyama T, Okada H, Saijo Y, Hasegawa Y, Nakajima H, Okamura T, Nakatani R, Ushigome E, Nakanishi N, Hamaguchi M, Fukui M, Archives of gerontology and geriatrics
Effects of alendronate and vitamin D on plasma metabolomic profiles in a rat model of osteoporosis.
BACKGROUND: Osteoporosis is a progressive bone disease and a significant global health issue, which places a serious economic and health burden on families and societies. Nitrogenated bisphosphonate drugs remain the first line therapy for treating osteoporosis, however their impact on bone cell metabolism and bone health after long term usage is difficult to determine for individual patients. As such, this study aimed to identify the metabolites in plasma that may serve as a diagnostic mechanism for measuring the extent of bisphosphonate drug suppression of bone loss in patients following long-term bisphosphonate drug therapy, and after active vitamin D stimulation of bisphosphonate-suppressed bone metabolism. Our approach was to evaluate combinations of alendronate bisphosphonate and active vitamin D treatment on those same plasma metabolites in an established rat model of osteoporosis, secondary to surgical ovariectomy. METHODS: Metabolomic analyses were performed using the commercially available Biocrates p180 metabolomics kit, which was run on a Sciex Qtrap 4000 mass spectrometer equipped with an Agilent HPLC system. Thirty 6-month old ovariectomized (OVX) rats were randomly assigned into three experimental groups, namely, control OVX rats, OVX rats dosed with alendronate, and a final group of OVX rats dosed with a combination of alendronate and active vitamin D. We used in vivo micro-Computed Tomography (μCT) imaging to confirm the developing osteoporosis phenotype in all ovariectomized rats, initially at baseline, and once more at the study endpoint of 8 weeks. Plasma from all rats was also collected at baseline and at 8 weeks and subjected to metabolomics analysis to identify potential osteoporosis biomarkers. We also determined the correlation between bone volume and specific plasma metabolites in an effort to create an osteoporosis screening tool of bisphosphonate drug metabolic suppression for potential use in clinical practice. RESULTS: Our analyses indicated that alendronate regulated several key plasma metabolites, including certain amino acids, lipids, and glucose, which are likely involved in bone resorption and formation. A distinct metabolite "fingerprint" was observed in all treatment groups compared to the control, with notable differences in metabolic changes. There was a correlation between four metabolites (proline, trans-hydroxyproline, histamine, and methionine) and micro-CT measured percent bone volume, indicating significant changes following ovariectomy surgery and with drug treatments. CONCLUSIONS: For our study, metabolomic profiling served as a useful research tool for elucidating the biological activity and toxicity of bisphosphonate drugs on metabolic bone cell activity. The approach could significantly aid in gauging the impact of long-term bisphosphonate drug usage in osteoporosis patients, for the assessment of osteoporosis drug therapy effectiveness, and to potentially avoid bisphosphonate-related adverse events of bone metabolism suppression. Our study outcomes suggest potential avenues for further research, although unexpected adverse events associated with active vitamin D treatment necessitate caution with interpretation. As such, our findings regarding the impact of vitamin D are exploratory in nature and require additional studies to confirm those findings.
Hamza A, Wishart D, Doschak MR, Journal of pharmacological and toxicological methods
Videos (6)
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Video Feed
Jan 12, 2014
The 2 Most Common Vitamin Deficiency
Dr. Tania Tyles Dempsey works with vitamins and supplements in her practice. She discusses the most common deficiencies she sees as well as the challenges to get some patients up[Read More...]
423 views
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Feb 4, 2015
Vitamin D: Does Less Sun Mean More Disease? By VitaminDWiki and AmpleEarth.com
Benefits of Sunlight and Vitamin D Around 9 out of 10 people you know are deficient in vitamin D, which we get from the sun. Find out why, what that does to you, and what you can do about it, right no...
247 views
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Dec 15, 2013
Vitamin D More Effective Than Flu Shot
The risk of children suffering from flu can be reduced by 50% if they take vitamin D, doctors in Japan have found. The finding has implications for flu epidemics since[Read More...]
240 views
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Jul 2, 2016
Are Vitamin D Supplements Worth It?
The post Are Vitamin D Supplements Worth It? appeared first on GreenMedTV.
152 views
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Apr 7, 2014
How Much Vitamin D Do We Need?
There are so many supplements with different amounts. What about vitamin D from the sun? How Much is an optimal daily amount? Dr. James Dowd is an expert in vitamin D. He offers suggestions on how to...
143 views
