Dec 19, 2012
Turmeric Extract Puts Drugs For Knee Osteoarthritis To Shame
turmeric is sparse, mainly due to the lack of capital available to fund expensive clinical
Sayer Ji
5 minSearch Research
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Found 12 results for "turmeric)"
Articles (6)
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May 24, 2013
Turmeric's Cardiovascular Benefits Found to be as Powerful as Exercise
turmeric extract does a pretty good job of producing some of the same cardiovascular health
Sayer Ji
5 min
Jun 10, 2013
Turmeric Produces 'Remarkable' Recovery in Alzheimer's Patients
Turmeric has been used in India for over 5,000 years, which is likely why still
Sayer Ji
12 min
Apr 30, 2015
Turmeric Boosts Working Memory In One Small Dose
turmeric powder was found to improve working memory in pre-diabetic patients. Interest in turmeric
Sayer Ji
3 min
Feb 02, 2017
Forbes Leads Media Attack Against Turmeric's Health Benefits
Turmeric's Health Benefits Tired of turmeric latte sipping hipsters and health nuts lauding the anecdotal
Sayer Ji
8 minAbstracts (6)
View allThe turmeric polyphenol calebin A relaxes rat aorta through Ca(V)1.2 channel inhibition with evidence for K(Ca)1.1 channel involvement.
<p>Calebin A, a naturally occurring polyphenol isolated from Curcuma longa, has attracted attention for its diverse pharmacological activities, although its vascular effects remain poorly defined. The present study investigated the vasorelaxant properties of calebin A in isolated rat blood vessels and explored the underlying molecular mechanisms using electrophysiological, functional, and computational approaches. Whole-cell patch-clamp recordings in rat tail artery smooth muscle cells showed that calebin A reduced Ba2+ currents through CaV1.2 channels in a concentration-dependent manner, accelerating current decay without significantly affecting voltage-dependent activation. Under experimental conditions favouring KCa1.1 current recording, calebin A also enhanced TEA-sensitive outward currents and modified spontaneous transient KCa1.1 current activity. Computational docking analyses identified plausible binding sites for calebin A on both CaV1.2 and KCa1.1 channels. Functional studies demonstrated concentration-dependent, endothelium-independent relaxation of phenylephrine-contracted thoracic aorta rings. Vasorelaxation was reduced under high extracellular K+ conditions, consistent with a contribution of K+ channel-dependent mechanisms. Moreover, calebin A significantly attenuated the contractile response elicited by restoration of extracellular Ca2+ influx under Ca2+-free conditions, whereas it did not significantly modify the contraction attributed to phenylephrine-induced intracellular Ca2+ release. Together, these findings support inhibition of CaV1.2 channels as a major mechanism underlying calebin A-induced vasorelaxation and support a contributory role for KCa1.1-dependent pathways, whose precise molecular basis requires further investigation. This dual pharmacological profile identifies calebin A as a promising template for the development of innovative vasorelaxant compounds acting through complementary mechanisms.</p>
De Rosa F, Pettini F, Spiga O, Atanasov AG, Fusi F, Biochemical pharmacology
Animal Study
Turmeric: A Comprehensive Review of Its Botany, Traditional Uses, Phytochemistry, and Mechanisms as a Functional Food.
<p>Objectives: This review aims to systematically summarize turmeric's botanical traits, traditional medicinal applications, phytochemical components and their biological activities, and to integrate botanical, phytochemical, molecular and clinical perspectives to provide a comprehensive theoretical foundation and practical guidance for the future scientific research and clinical applications of turmeric as a functional food. Methods: A systematic overview and comprehensive analysis were conducted on the existing research about turmeric, covering its botanical characteristics, traditional medicinal application value, the biological mechanisms of major bioactive compounds (especially curcumin), pharmacokinetic properties, and the latest progress in relevant clinical trials. Results: Turmeric has important historical and cultural significance in traditional medicine, and its major bioactive compound curcumin is the core of its therapeutic potential, which can modulate antioxidant, anti-inflammatory, and antitumor signaling pathways. Recent studies have found that curcumin exerts significant biological effects by regulating noncoding RNAs (ncRNAs) and epigenetic modifications, showing a promising role in cancer chemoprevention. Meanwhile, curcumin has specific pharmacokinetic properties, and current clinical trials on turmeric and curcumin have made certain progress, yet challenges such as low bioavailability and limited therapeutic efficacy still exist. Conclusions: Turmeric, as a widely recognized functional food with rich phytochemicals and diverse biological activities, has great potential in scientific research and clinical application, especially in cancer chemoprevention. Solving the key challenges such as curcumin's bioavailability and therapeutic efficacy is the core direction for the future development and utilization of turmeric, and the multi-dimensional research perspective can provide more comprehensive support for its practical application as a functional food.</p>
Wang Z, Zhong W, Zhao W, Zhou Q, Wang Y, Zhang B, Lin Z, Nutrients
Review
Safety assessment and gastrointestinal tolerance of a novel highly bioavailable turmeric extract formulation: A randomised, double-blind, placebo controlled clinical trial.
Recent advances have led the development of turmeric formulations providing notable blood levels of curcuminoids following ingestion. However, there is a lack of clinical trials confirming the tolerability and safety of these formulations after repeated consumption by healthy subjects, as previous studies have primarily focused on efficacy and safety in subjects with health conditions. This randomised controlled trial assessed the gastrointestinal tolerance and safety of a novel turmeric extract formulation (TF) in healthy adults. Sixty subjects were assigned to either the TF group, receiving 1000 mg or placebo group (maltodextrin), once daily for 5 weeks. The study evaluated: gastrointestinal tolerance [including bloating, abdominal cramping, stomach noises, flatulence, frequency and consistency of stools and perception of Gastrointestinal Quality of Life (GIQLI)], a comprehensive analysis of haematology, clinical biochemistry and urinalysis parameters, vital signs, and a record of adverse events (AEs). No statistically significant differences were observed in gastrointestinal tolerance between the groups. Clinical parameters were not adversely affected by TF consumption, and the incidence and severity of AEs were similar in both groups. In conclusion, daily oral consumption of 1000 mg TF, thus exceeding the recommended 300 mg dose, was well tolerated and safe in healthy adults over the 5-week period.
Laval J, Phipps KR, Brinet S, Fournier MC, Douillard B, Pham S, Lobach A, Mueller S, Fança-Berthon P, Toxicology reports
Turmeric extracellular vesicles-derived "all-in-one" nanoagent enables full-cycle synergistic immunomodulation of lung cancer.
Lung cancer's metastatic propensity and recurrence prevalence necessitate innovative immunotherapy strategies beyond conventional single-mode regulation. We engineered low-capacity turmeric-derived extracellular vesicles (TEVs) that integrated with zeolitic imidazolate framework-8 (ZIF-8) to construct an "all-in-one" nanoagent, addressing both high drug loading nanocarriers production and immunologically cold tumor challenges. The system co-delivered chlorin e6 (Ce6) and PD-L1 siRNA, while exploited TEVs' inherent curcumin for Wnt/β-catenin pathway inhibition. Ce6-mediated photodynamic therapy (PDT) induced immunogenic cell death (ICD), releasing damage associated molecular patterns (DAMPs) to activate antigen-presenting cells (APCs). Compared with control groups, artificial intelligence model confirmed the role of curcumin in enhancing immune infiltration by 6.1-fold. PD-L1 siRNA synergistically downregulates the checkpoint expression with a 66 % reduction to prevent the immune escape. This coordinated strategy achieved full-cycle immunomodulation: (1) ICD initiated antigens release, (2) Wnt/β-catenin pathway inhibition drived T cell infiltration, and (3) PD-L1 blockade receded the immune escape. results demonstrated that 64 % primary tumor suppression and 81 % metastasis reduction versus monotherapy groups. The ZIF-8@TEV hybrid platform exhibited 12.8 % payload loading efficiency, surpassing liposomal carriers by 4.7-fold. This study established a scalable nanoengineering approach to transform immunosuppressive tumors into immunotherapy-responsive targets through a full-cycle immune coordination.
Yang J, Wu Q, Fu Y, Chen X, Chen H, Wang Y, Wu X, Cui X, Wang S, Luo Y, Zhang Y, Li Y, Zhao Y, Cha Z, Shi L, Jiao X, Li F, Luo Y, Bioactive materials
Evaluation of the Combined Therapeutic Potential of Turmeric and Donepezil on the Cholinergic System in a Mouse Model of AD-like Pathology.
INTRODUCTION: The multifactorial pathogenesis of Alzheimer's Disease (AD) makes effective prevention and treatment challenging. Integrative medicine presents a promising approach by complementing conventional treatments with neuroprotective nutraceuticals. This study investigates the individual and combinatorial effects of turmeric, a neuroprotective herb, and donepezil, an acetylcholinesterase (AChE) inhibitor, on cognitive functions in a scopolamine-induced amnesic mouse model. METHODS: Molecular interactions of curcuminoids and donepezil with AChE were analyzed using AutoDock Vina and AMBER22. In animal model studies, amnesia was induced in BALB/c mice via subcutaneous injections of scopolamine (1mg/kg/day) for a duration of 25 days. From the 11th day onwards, the turmeric rhizome powder (20mg/kg/day) and donepezil (0.5mg/kg/day) were orally administered as monotherapies or in combination. Cognitive functions were assessed through behavior tests. RESULTS: Molecular docking and dynamics simulations revealed that curcuminoids (curcumin, bisdemethoxycurcumin, and desmethoxycurcumin) inhibited AChE more effectively than donepezil. Animal studies demonstrated significant enhancements in spatial, reference, recognition, and contextual fear memories, with both turmeric and donepezil monotherapies, and their combination therapy. No significant differences were observed between monotherapies, and no additive effect was evident in the combination therapy. DISCUSSION: Co-administration of turmeric and donepezil did not yield a significant additive effect on cognitive improvement in scopolamine-induced amnesic mice. Turmeric monotherapy showed cognitive improvements comparable to those of donepezil monotherapy, highlighting its potential as a candidate therapy for donepezil-resistant AD. CONCLUSION: Turmeric monotherapy improved cognitive performance similarly to donepezil monotherapy in scopolamine-induced amnesic mice. These preliminary findings require further research, including dose optimization and clinical trials, to establish their clinical relevance.
Justin S, Ali SA, Masood M, Abbasi SW, Farhat SM, Shakeel R, Khalid A, Mahboob A, Zafar S, Zahid S, Ahmed T, Current drug targets
