18β-Glycyrrhetinic Acid

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9 Diseases Researched for 18β-Glycyrrhetinic Acid

Name	AC	CK
Helicobacter Pylori Infection	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	1
Liver Cancer	1	1
Lung Cancer	1	1
MRSA	1	1
Neurodegenerative Diseases	1	1
Non-Small-Cell Lung Carcinoma	1	1
Parkinson's Disease	1	1
Parkinsonian Disorders	1	1

13 Pharmacological Actions Researched for 18β-Glycyrrhetinic Acid

Name	AC	CK
Anti-Inflammatory Agents	2	3
Cyclooxygenase 2 Inhibitors	2	3
Tumor Necrosis Factor (TNF) Alpha Inhibitor	2	3
Antiproliferative	2	2
Gastroprotective	1	2
Interleukin-1 beta downregulation	1	2
Anti-Bacterial Agents	1	1
Apoptotic	1	1
Chemopreventive	1	1
Chemoprotective Agents	1	1
Dopamine Antagonists	1	1
Dopamine Receptor D3 Antagonist	1	1
Neuroprotective Agents	1	1

Research Articles 5
Cumulative Knowledge Score 8
Overall Research Rating GOOD

View the Evidence:
14 Abstracts with 18β-Glycyrrhetinic Acid Research

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[+]

18α-glycyrrhetinic acid ameliorates fructose-induced nephropathy.Apr 30, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2020 May ;125:109702. Epub 2020 Feb 25. PMID: 32106383

Article Published Date : Apr 30, 2020

Study Type : Animal Study

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Substances : 18β-Glycyrrhetinic Acid

Diseases : Dyslipidemias, High Fructose Diet, Inflammation, Nephropathy, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective

[+]

18β-glycyrrhetinic acid acts through hepatocyte nuclear factor 4 alpha to modulate lipid and carbohydrate metabolism. Apr 27, 2020

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Pubmed Data : Pharmacol Res. 2020 Apr 28 ;157:104840. Epub 2020 Apr 28. PMID: 32353589

Article Published Date : Apr 27, 2020

Study Type : Animal Study

Additional Links

Substances : 18β-Glycyrrhetinic Acid

Diseases : High Fat Diet

Pharmacological Actions : Hypolipidemic

[+]

18β-glycyrrhetinic acid improves cardiac diastolic function by attenuating intracellular calcium overload.Jul 31, 2020

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Pubmed Data : Curr Med Sci. 2020 Aug ;40(4):654-661. Epub 2020 Aug 29. PMID: 32862375

Article Published Date : Jul 31, 2020

Study Type : Animal Study

Additional Links

Substances : 18β-Glycyrrhetinic Acid

Diseases : Heart Failure, Myocardial Ischemia

Pharmacological Actions : Cardioprotective

[+]

18β-glycyrrhetinic acid is a promising novel candidate in the treatment of osteoclast-related diseases such as postmenopausal osteoporosis.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2018 ;9:647. Epub 2018 Jun 20. PMID: 29973878

Article Published Date : Dec 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : 18β-Glycyrrhetinic Acid

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

[+]

18β-Glycyrrhetinic acid significantly attenuated H. pylori-infected gastritis in gerbils.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Res Int. 2016 ;2016:4943793. Epub 2016 Feb 24. PMID: 27006947

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : 18β-Glycyrrhetinic Acid

Diseases : Helicobacter Pylori Infection

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Gastroprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

18β-glycyrrhetinic acid treatment can protect the brain tissue against experimental allergic encephalomyelitis.Jul 26, 2018

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Pubmed Data : Immunopharmacol Immunotoxicol. 2018 Jul 27:1-9. Epub 2018 Jul 27. PMID: 30052483

Article Published Date : Jul 26, 2018

Study Type : Animal Study

Additional Links

Substances : 18β-Glycyrrhetinic Acid

Diseases : Encephalomyelitis, Multiple Sclerosis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Glycyrrhetinic acid ameliorates imiquimod-induced psoriasis-like skin lesions in mice.Jan 02, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Pharmacol Toxicol. 2020 06 3 ;21(1):41. Epub 2020 Jun 3. PMID: 32493482

Article Published Date : Jan 02, 2020

Study Type : Animal Study

Additional Links

Substances : 18β-Glycyrrhetinic Acid

Diseases : Psoriasis

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Vasorelaxation effect of 18β-glycyrrhetinic acid on the thoracic aorta of rats.Dec 31, 2018

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Pubmed Data : Pharmazie. 2019 12 1 ;74(12):751-754. PMID: 31907117

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : 18β-Glycyrrhetinic Acid

Diseases : Hypertension

Pharmacological Actions : Vasodilator Agents

[+]

18β-Glycyrrhetinic Acid exhibits anti-MRSA properties.Oct 30, 2012

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Pubmed Data : Antimicrob Agents Chemother. 2012 Oct 31. Epub 2012 Oct 31. PMID: 23114775

Article Published Date : Oct 30, 2012

Study Type : In Vitro Study

Additional Links

Substances : 18β-Glycyrrhetinic Acid

Diseases : MRSA

Pharmacological Actions : Anti-Bacterial Agents

[+]

18β-glycyrrhetinic acid has significance with respect to prevention and treatment of NSCLC by inhibiting TxAS.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2014 ;9(4):e93690. Epub 2014 Apr 2. PMID: 24695790

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : 18β-Glycyrrhetinic Acid, Licorice

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Lung Cancer, Non-Small-Cell Lung Carcinoma

Pharmacological Actions : Antiproliferative , Chemoprotective Agents

[+]

18β-Glycyrrhetinic acid may be used as a chemopreventive agent in liver cancer.Apr 25, 2016

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Pubmed Data : Mol Cell Biochem. 2016 Apr 26. Epub 2016 Apr 26. PMID: 27116616

Article Published Date : Apr 25, 2016

Study Type : In Vitro Study

Additional Links

Substances : 18β-Glycyrrhetinic Acid

Diseases : Liver Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Chemopreventive, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

18β-glycyrrhetinic acid might represent a potential therapeutic agent for blocking inflammatory responses in airways.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mediators Inflamm. 2018 ;2018:6461032. Epub 2018 May 15. PMID: 29861658

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : 18β-Glycyrrhetinic Acid

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

[+]

18β-Glycyrrhetinic-acid-mediated unfolded protein response induces autophagy and apoptosis in hepatocellular carcinomaJun 18, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2018 Jun 19 ;8(1):9365. Epub 2018 Jun 19. PMID: 29921924

Article Published Date : Jun 18, 2018

Study Type : In Vitro Study

Additional Links

Substances : 18β-Glycyrrhetinic Acid

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic, Autophagy Up-regulation

[+]

Glycyrrhetinic acid and E.resveratroloside are potent compounds having high binding energies which should be considered as potential lead compounds for drug development against PD.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2015 ;9:187-98. Epub 2014 Dec 18. PMID: 25565772

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : 18β-Glycyrrhetinic Acid

Diseases : Neurodegenerative Diseases, Parkinson's Disease, Parkinsonian Disorders

Pharmacological Actions : Dopamine Antagonists, Dopamine Receptor D3 Antagonist, Neuroprotective Agents

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Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 14 Abstracts with 18β-Glycyrrhetinic Acid Research

Limited to Members Only

Currently Available Sorting Options

18α-glycyrrhetinic acid ameliorates fructose-induced nephropathy.Apr 30, 2020

18β-glycyrrhetinic acid acts through hepatocyte nuclear factor 4 alpha to modulate lipid and carbohydrate metabolism. Apr 27, 2020

18β-glycyrrhetinic acid improves cardiac diastolic function by attenuating intracellular calcium overload.Jul 31, 2020

18β-glycyrrhetinic acid is a promising novel candidate in the treatment of osteoclast-related diseases such as postmenopausal osteoporosis.Dec 31, 2017

18β-Glycyrrhetinic acid significantly attenuated H. pylori-infected gastritis in gerbils.Dec 31, 2015

18β-glycyrrhetinic acid treatment can protect the brain tissue against experimental allergic encephalomyelitis.Jul 26, 2018

Glycyrrhetinic acid ameliorates imiquimod-induced psoriasis-like skin lesions in mice.Jan 02, 2020

Vasorelaxation effect of 18β-glycyrrhetinic acid on the thoracic aorta of rats.Dec 31, 2018

18β-Glycyrrhetinic Acid exhibits anti-MRSA properties.Oct 30, 2012

18β-glycyrrhetinic acid has significance with respect to prevention and treatment of NSCLC by inhibiting TxAS.Dec 31, 2013

18β-Glycyrrhetinic acid may be used as a chemopreventive agent in liver cancer.Apr 25, 2016

18β-glycyrrhetinic acid might represent a potential therapeutic agent for blocking inflammatory responses in airways.Dec 31, 2017

18β-Glycyrrhetinic-acid-mediated unfolded protein response induces autophagy and apoptosis in hepatocellular carcinomaJun 18, 2018

Glycyrrhetinic acid and E.resveratroloside are potent compounds having high binding energies which should be considered as potential lead compounds for drug development against PD.Dec 31, 2014

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18β-Glycyrrhetinic Acid

View the Evidence:
14 Abstracts with 18β-Glycyrrhetinic Acid Research