6-Shogaol

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84 Diseases Researched for 6-Shogaol
NameACCKFocus
Breast Cancer711Locked
Myelodysplastic Syndrome110Locked
Inflammation67Locked
Brain Inflammation 36Locked
Lung Cancer56Locked
Parkinson's Disease46Locked
Breast Cancer Stem Cells15Locked
Cancers: All55Locked
Colon Cancer55Locked
Liver Cancer55Locked
Neurodegenerative Diseases45Locked
Oxidative Stress45Locked
Breast Cancer: Triple Negative 34Locked
Dementia24Locked
Lung Cancer: Prevention24Locked
Pancreatic Cancer24Locked
Ulcerative Colitis24Locked
Aging23Locked
Alzheimer's Disease33Locked
Carcinoma: Non-Small-Cell Lung23Locked
Diabetes Mellitus: Type 223Locked
Diabetic Complications23Locked
Head and Neck Cancer23Locked
Kidney Cancer33Locked
Periodontitis23Locked
Acetaminophen (Tylenol) Toxicity 12Locked
Acute lymphoblastic leukemia (ALL)12Locked
Aluminum Toxicity 12Locked
Brain Injury: Traumatic12Locked
Cancer Metastasis22Locked
Cancers: Drug Resistant22Locked
Cervical Cancer22Locked
Chemically-Induced Liver Damage12Locked
Chemotherapy-Induced Toxicity: Oxaliplatin12Locked
Depression12Locked
Diabetes Mellitus: Type 112Locked
Diabetic Nephropathy12Locked
Diabetic Neuropathy12Locked
Endometriosis12Locked
High Fat Diet12Locked
Huntington Disease12Locked
Hyperglycemia22Locked
Ischemia12Locked
Kidney Damage12Locked
Kidney Damage: Chemically-Induced12Locked
Leukemia12Locked
Lipopolysaccharide-Induced Toxicity22Locked
Liver Damage: Drug-Induced12Locked
Liver Fibrosis12Locked
Multiple Sclerosis12Locked
Myocardial Ischemia12Locked
Neuropathic Pain12Locked
Obesity12Locked
Osteoarthritis: Knee12Locked
Prostate Cancer22Locked
Urolithiasis12Locked
Acute Myeloid Leukemia11Locked
Advanced Glycation End products (AGE)11Locked
Advanced Glycation Endproduct (AGE) Formation11Locked
Arthritis11Locked
Asthma11Locked
Atherosclerosis11Locked
Brain Ischemia11Locked
Breast Cancer: Metastatic11Locked
Candida Albicans11Locked
Candida Infection 11Locked
Cardiomyopathy11Locked
Cardiovascular Diseases11Locked
Cholesterol: Oxidation11Locked
Colorectal Cancer11Locked
Coronavirus Infection11Locked
Fatty Liver11Locked
Gastrointestinal Cancer11Locked
Glioma11Locked
Hypertension11Locked
Liposarcoma 11Locked
Liver Steatosis11Locked
Lung Inflammation11Locked
Oral Cancer11Locked
Ovarian Cancer11Locked
Rheumatoid Arthritis11Locked
Skin Diseases11Locked
Ultraviolet Radiation Induced Damage11Locked
Vitiligo11Locked
59 Pharmacological Actions Researched for 6-Shogaol
NameACCKFocus
Anti-Inflammatory Agents2336Locked
Apoptotic3035Locked
Antiproliferative 2126Locked
Neuroprotective Agents1320Locked
Antioxidants1318Locked
NF-kappaB Inhibitor1115Locked
Chemopreventive1012Locked
Interleukin-1 beta downregulation612Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor612Locked
Interleukin-6 Downregulation59Locked
Cell cycle arrest68Locked
Chemosensitizer48Locked
Nrf2 activation68Locked
Anti-Apoptotic57Locked
Anti-metastatic67Locked
Chemotherapeutic67Locked
Hepatoprotective47Locked
Antineoplastic Agents56Locked
Cardioprotective46Locked
Renoprotective36Locked
Anticarcinogenic Agents45Locked
Autophagy Up-regulation45Locked
Cyclin D1 Down-Regulation15Locked
Heme oxygenase-1 up-regulation35Locked
STAT3 Inhibitor45Locked
Analgesics24Locked
Gastrointestinal Agents23Locked
Hypoglycemic Agents23Locked
Neuritogenic23Locked
Anti-Glycation Agents22Locked
Caspase-3 Activation12Locked
Chemoprotective Agents12Locked
Cyclooxygenase 2 Inhibitors12Locked
Glutathione Upregulation 12Locked
Hypolipidemic12Locked
Immunomodulatory12Locked
Interleukin-18 down-regulation12Locked
Pancreato Protective Agents12Locked
Paraptosis22Locked
Postaglandin PGE2 downregulation 12Locked
Tumor Suppressor Protein p53 Upregulation22Locked
Alpha-glucosidase inhibitor 11Locked
Angiogenesis Inhibitors11Locked
Anti-Asthmatic Agents11Locked
Anti-Bacterial Agents11Locked
Anti-Proliferative11Locked
Anti-fungal effects11Locked
Autophagy Inhibitors11Locked
Bcl-2 protein down-regulation11Locked
Enzyme Inhibitors11Locked
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor11Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor11Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor11Locked
MicroRNA modulator11Locked
Photoprotective11Locked
Prostaglandin PGE2 downregulation11Locked
Radiosensitizer11Locked
Wnt/β-catenin pathway down-regulation11Locked
Wnt/β-catenin signaling pathway modulation11Locked

View the Evidence:
97 Abstracts with 6-Shogaol Research

[+]

6-shogaol caused a decrease in serum ferritin levels in 3 of 6 patients with early Myelodysplastic syndrome.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Med Insights Blood Disord. 2017 ;10:1179545X17738755. Epub 2017 Nov 2. PMID: 29147080
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : 6-Shogaol, Ginger
Diseases : Myelodysplastic Syndrome
[+]

6-shogaol, 6-gingerol and pterostilbene selectively killed breast cancer stem cells.Mar 10, 2015

Pubmed Data : J Agric Food Chem. 2015 Mar 11 ;63(9):2432-41. Epub 2015 Feb 25. PMID: 25686711
Article Published Date : Mar 10, 2015
Study Type : Human In Vitro
Additional Links
Substances : 6-Shogaol, Gingerol , Pterostilbene
Diseases : Breast Cancer, Breast Cancer Stem Cells
Pharmacological Actions : Chemosensitizer, Cyclin D1 Down-Regulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

6-shogaol against 3-Nitropropionic acid-induced Huntington's disease.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2024 ;19(7):e0305358. Epub 2024 Jul 15. PMID: 39008492
Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Huntington Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

6-Shogaol alleviates CCl4-induced liver fibrosis by attenuating inflammatory response.Apr 27, 2022

Pubmed Data : Acta Biochim Pol. 2022 Apr 28 ;69(2):363-370. PMID: 35485077
Article Published Date : Apr 27, 2022
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor
[+]

6-Shogaol ameliorates diabetic nephropathy through anti-inflammatory, hyperlipidemic, anti-oxidative activity.Dec 31, 2017

Pubmed Data : Biomed Pharmacother. 2018 Jan ;97:633-641. Epub 2017 Nov 6. PMID: 29101807
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hypolipidemic, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

6-shogaol and 6-gingerol active ingredients may improve neuropathic pain.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Turk J Med Sci. 2023 ;53(6):1593-1604. Epub 2023 Oct 31. PMID: 38813490
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol, Gingerol
Diseases : Neuropathic Pain
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

6-shogaol and could be a cost-effective candidate for the prevention and treatment of urolithiasis.May 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2021 Jun ;28(6):3418-3423. Epub 2021 Mar 14. PMID: 34121880
Article Published Date : May 31, 2021
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Aluminum Toxicity , Kidney Damage: Chemically-Induced, Urolithiasis
Pharmacological Actions : Renoprotective
Problem Substances : Aluminum Chloride
[+]

6-shogaol attenuates oxaliplatin-induced allodynia.Jun 07, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2022 Jun 8 ;15(6). Epub 2022 Jun 8. PMID: 35745645
Article Published Date : Jun 07, 2022
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Chemotherapy-Induced Toxicity: Oxaliplatin
Pharmacological Actions : Chemoprotective Agents, Neuroprotective Agents
[+]

6-shogaol can be used as a therapeutic agent for preventing complications in diabetic patients.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Diabetol Metab Syndr. 2019 ;11:15. Epub 2019 Feb 12. PMID: 30805033
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Diabetes Mellitus: Type 1, Diabetic Complications
Pharmacological Actions : Hepatoprotective, Pancreato Protective Agents, Renoprotective
[+]

6-Shogaol decreases cancer-induced up-regulation of CCL2 in TADCs, preventing the enhancing effects of TADCs on tumorigenesis and metastatic properties in A549 and MDA-MB-231 cells.Feb 17, 2015

Pubmed Data : J Agric Food Chem. 2015 Feb 18 ;63(6):1730-8. Epub 2015 Feb 9. PMID: 25621970
Article Published Date : Feb 17, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Breast Cancer: Triple Negative , Lung Cancer, Lung Cancer: Prevention
Pharmacological Actions : Anti-metastatic, Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Cancer Stem Cells
[+]

6-shogaol effectively induces cell apoptosis in transformed and primary human leukemia cells, as well as in leukemia xenografts.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Cancer. 2013 ;12(1):135. Epub 2013 Nov 12. PMID: 24215632
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

6-Shogaol exerts neuroprotective effects on dopaminergic neurons in vitro and in vivo parkinson's disease models.Aug 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharmacol Sin. 2013 Sep ;34(9):1131-9. Epub 2013 Jul 1. PMID: 23811724
Article Published Date : Aug 31, 2013
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Brain Inflammation , Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

6-shogaol from dried ginger protects against intestinal ischemia/reperfusion.Jun 30, 2023

Pubmed Data : Mol Nutr Food Res. 2023 Jul ;67(13):e2200773. Epub 2023 May 14. PMID: 37118920
Article Published Date : Jun 30, 2023
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol, Ginger
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

6-Shogaol induces apoptosis in acute lymphoblastic leukaemia cells.May 02, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2021 May 3. Epub 2021 May 3. PMID: 33939282
Article Published Date : May 02, 2021
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Acute lymphoblastic leukemia (ALL)
Pharmacological Actions : Apoptotic
[+]

6-Shogaol inhibits osteoclastogenesis and alveolar bone resorption in ligature-induced periodontitis.Oct 31, 2019

Pubmed Data : J Periodontol. 2019 Nov 1. Epub 2019 Nov 1. PMID: 31675438
Article Published Date : Oct 31, 2019
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

6-shogaol may play a role in inhibiting glial cell activation and reducing memory impairment in animal models of dementia. Jun 19, 2014

Pubmed Data : Biochem Biophys Res Commun. 2014 Jun 20 ;449(1):8-13. Epub 2014 May 2. PMID: 24796668
Article Published Date : Jun 19, 2014
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Brain Inflammation , Dementia
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

6-Shogaol protects against ischemic acute kidney injury by modulating NFκB and heme oxygenase-1 pathways.Jul 16, 2019

Pubmed Data : Am J Physiol Renal Physiol. 2019 Jul 17. Epub 2019 Jul 17. PMID: 31313953
Article Published Date : Jul 16, 2019
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Ischemia, Kidney Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Renoprotective
[+]

6-Shogaol protects against isoproterenol-induced cardiac injury.Nov 30, 2022

Pubmed Data : J Physiol Pharmacol. 2022 Dec ;73(6). Epub 2023 Apr 17. PMID: 37087565
Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

6-Shogaol reduces progression of experimental endometriosis.Oct 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Physiol Pharmacol. 2018 Nov ;22(6):627-636. Epub 2018 Oct 25. PMID: 30402023
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Endometriosis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation
[+]

6-Shogaol treatment improves experimental knee osteoarthritis.Jun 26, 2022

Pubmed Data : Br J Pharmacol. 2022 Jun 27. Epub 2022 Jun 27. PMID: 35760458
Article Published Date : Jun 26, 2022
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
[+]

6-Shogaol treatment produced beneficial effects for TBI-induced anxiety/depression-like behaviors.Jan 10, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ACS Omega. 2022 Jan 11 ;7(1):140-148. Epub 2021 Dec 28. PMID: 35036685
Article Published Date : Jan 10, 2022
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Brain Injury: Traumatic, Depression
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Coadministration of 6-shogaol and levodopa alleviates Parkinson's disease-related pathology.Aug 01, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2024 Aug 2. Epub 2024 Aug 2. PMID: 39092515
Article Published Date : Aug 01, 2024
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Brain Inflammation , Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Effects of 6-shogaol on notch signalling pathway in colonic epithelial cells of ulcerative colitis.Jan 27, 2020

Pubmed Data : Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2020 Jan 28 ;36(1):90-93. PMID: 32476379
Article Published Date : Jan 27, 2020
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Ulcerative Colitis
Pharmacological Actions : Gastrointestinal Agents
[+]

Ginger extract inhibited cell proliferation and subsequently induced the autotic death of pancreatic cancer Panc-1 cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(5):e0126605. Epub 2015 May 11. PMID: 25961833
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol, Ginger, Gingerol
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Autophagy Up-regulation
[+]

Ginger extracts and its compound, 6-shogaol could reduce pain symptoms in painful diabetic neuropathy.Nov 15, 2019

Pubmed Data : J Ethnopharmacol. 2019 Nov 16. Epub 2019 Nov 16. PMID: 31743763
Article Published Date : Nov 15, 2019
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol, Ginger
Diseases : Diabetic Neuropathy
Pharmacological Actions : Analgesics
[+]

Lifespan-extending property of 6-shogaol from Zingiber officinale Roscoe in Caenorhabditis elegans.Jun 30, 2018

Pubmed Data : Arch Pharm Res. 2018 Jul ;41(7):743-752. Epub 2018 Jul 6. PMID: 29978428
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Aging
Pharmacological Actions : Antioxidants
[+]

Low concentrations of 6-shogaol was not cytotoxic and induced neuritogenesis in PC-12 cells.Jun 23, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2017 Jun 24 ;17(1):334. Epub 2017 Jun 24. PMID: 28646880
Article Published Date : Jun 23, 2017
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Neuritogenic
[+]

Neuroprotective effects of 6-shogaol and its metabolite, 6-paradol, in a mouse model of Multiple sclerosis.Jul 12, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2018 Jul 13. Epub 2018 Jul 13. PMID: 30001610
Article Published Date : Jul 12, 2018
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Multiple Sclerosis
Pharmacological Actions : Neuroprotective Agents
[+]

Oral delivery of nanoparticles loaded with 6-Shogaol attenuates ulcerative colitis and promotes wound healing.Jan 23, 2018

Pubmed Data : J Crohns Colitis. 2018 Jan 24 ;12(2):217-229. PMID: 28961808
Article Published Date : Jan 23, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Pretreatment with 6-shogaol resulted in an inhibition of constitutive and gemcitabine induced NF-κB activity and exerted its chemosensitization effects to gemcitabine.Feb 28, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : AAPS J. 2014 Mar ;16(2):246-57. Epub 2014 Jan 15. PMID: 24424498
Article Published Date : Feb 28, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Pancreatic Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemotherapeutic, NF-kappaB Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

The current study clearly indicates that 6-shogaol can be exploited for the prevention and treatment of NSCLC.Feb 28, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Carcinogenesis. 2014 Mar ;35(3):683-91. Epub 2013 Nov 26. PMID: 24282290
Article Published Date : Feb 28, 2014
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer: Prevention
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Cell cycle arrest, Chemopreventive, STAT3 Inhibitor
[+]

The present study suggests that 6-shogaol is a potential novel candidate for anti-HNSCCs therapy.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Med Sci. 2023 ;20(2):238-246. Epub 2023 Jan 22. PMID: 36794162
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Head and Neck Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

The results also indicated that 6-paradol could be considered as an active anti-hyperglycemic component of ginger.Jan 16, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Jan 17 ;18(1). Epub 2017 Jan 17. PMID: 28106738
Article Published Date : Jan 16, 2017
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol, Gingerol
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Phytotherapy
[+]

Therapeutic effect of 6-shogaol on acetaminophen-induced hepatotoxicity.Sep 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur Rev Med Pharmacol Sci. 2022 Oct ;26(20):7371-7378. PMID: 36314307
Article Published Date : Sep 30, 2022
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Glutathione Upregulation , Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

These results demonstrated that sustained activation of the PPARδ pathway with GE attenuated diet-induced obesity and improved exercise endurance capacity.May 27, 2015

Pubmed Data : J Nutr Biochem. 2015 May 28. Epub 2015 May 28. PMID: 26101135
Article Published Date : May 27, 2015
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol, Ginger, Gingerol
Diseases : High Fat Diet, Obesity
Additional Keywords : Anti-Obesity Agents, Plant Extracts
[+]

Western diet-induced fear memory impairment is attenuated by 6-shogaol in C57BL/6N mice.Dec 05, 2019

Pubmed Data : Behav Brain Res. 2019 Dec 6:112419. Epub 2019 Dec 6. PMID: 31816337
Article Published Date : Dec 05, 2019
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Dementia
Pharmacological Actions : Neuroprotective Agents
Anti Therapeutic Actions : Western Diet
[+]

6-S is a novel small molecule activator of Nrf2 in PC12 cells, and suggests that 6-S might be a potential candidate for the prevention of oxidative stress-mediated neurodegenerative disorders.Aug 04, 2015

Pubmed Data : Food Funct. 2015 Aug 5 ;6(8):2813-23. Epub 2015 Jul 14. PMID: 26169810
Article Published Date : Aug 04, 2015
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Neurodegenerative Diseases, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

6-Shogaol alleviates high-fat diet induced hepatic steatosis.Oct 31, 2024

Pubmed Data : Food Chem. 2024 Nov 1 ;457:140197. Epub 2024 Jun 25. PMID: 38941907
Article Published Date : Oct 31, 2024
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Fatty Liver, Liver Steatosis
Pharmacological Actions : Hepatoprotective
[+]

6-shogaol and 10-shogaol synergize curcumin in ameliorating proinflammatory mediatorsNov 01, 2022

Pubmed Data : Biomol Ther (Seoul). 2022 Nov 2. Epub 2022 Nov 2. PMID: 36319441
Article Published Date : Nov 01, 2022
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol, Curcumin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Nrf2 activation
Additional Keywords : Natural Substance Synergy
[+]

6-shogaol and curcumin might be effective on GSK3β pathway via lowering PGE2 levels.Oct 24, 2016

Pubmed Data : Chem Biol Interact. 2016 Oct 25 ;258:257-65. Epub 2016 Aug 16. PMID: 27645308
Article Published Date : Oct 24, 2016
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol, Curcumin, Gingerol
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Prostaglandin PGE2 downregulation
[+]

6-shogaol as a novel thioredoxin reductase inhibitor induces oxidative-stress-mediated apoptosis in HeLa cells.Mar 03, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2023 Mar 4 ;24(5). Epub 2023 Mar 4. PMID: 36902397
Article Published Date : Mar 03, 2023
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Cervical Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Enzyme Inhibitors
[+]

6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-γ.Mar 29, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Mar 30. Epub 2017 Mar 30. PMID: 28410218
Article Published Date : Mar 29, 2017
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

6-shogaol can interfere with multiple signaling cascades involved in tumorigenesis and can be used as a potential therapeutic candidate for both the prevention and treatment of cancer.Jun 23, 2014

Pubmed Data : Mol Carcinog. 2014 Jun 24. Epub 2014 Jun 24. PMID: 24962868
Article Published Date : Jun 23, 2014
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Pharmacological Actions : Anti-Proliferative, Anticarcinogenic Agents, Apoptotic, Chemopreventive, STAT3 Inhibitor
[+]

6-shogaol enhances the anticancer effect of 5-fluorouracil, oxaliplatin, and irinotecan via increase of apoptosis and autophagy in colon cancer cells.May 10, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2020 May 11 ;20(1):141. Epub 2020 May 11. PMID: 32393373
Article Published Date : May 10, 2020
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Oxaliplatin
[+]

6-shogaol enhances TRAIL-mediated apoptosis in renal carcinoma Caki cells via ROS-mediated cytochrome c release and down-regulation of c-FLIP(L) expression.Feb 24, 2015

Pubmed Data : Chem Biol Interact. 2015 Feb 25 ;228:69-78. Epub 2015 Jan 22. PMID: 25619640
Article Published Date : Feb 24, 2015
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Breast Cancer: Triple Negative , Glioma, Kidney Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Selective Cytotoxicity
[+]

6-Shogaol exhibits a promoting effect with tax via binding HSP60 in non-small-cell lung cancer.Nov 18, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2022 Nov 19 ;11(22). Epub 2022 Nov 19. PMID: 36429106
Article Published Date : Nov 18, 2022
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Chemotherapeutic
[+]

6-Shogaol Exhibits Anti-viral and Anti-inflammatory Activity in COVID-19-Associated Inflammation.Jan 16, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ACS Omega. 2023 Jan 17 ;8(2):2618-2628. Epub 2023 Jan 6. PMID: 36687062
Article Published Date : Jan 16, 2023
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Coronavirus Infection, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

6-Shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K/Akt/mTOR pathway.Jan 07, 2021

Pubmed Data : Eur J Nutr. 2021 Jan 8. Epub 2021 Jan 8. PMID: 33416981
Article Published Date : Jan 07, 2021
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative
[+]

6-shogaol induces apoptosis and enhances radiosensitivity in head and neck squamous cell carcinoma cell lines.Nov 22, 2017

Pubmed Data : Phytother Res. 2017 Nov 23. Epub 2017 Nov 23. PMID: 29168275
Article Published Date : Nov 22, 2017
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Head and Neck Cancer
Pharmacological Actions : Apoptotic, Radiosensitizer
[+]

6-shogaol induces apoptosis in Hep-2 cells through inducing oxidative damage and modulate apoptotic marker expressions.Jul 31, 2016

Pubmed Data : Biomed Pharmacother. 2016 Aug ;82:226-36. Epub 2016 May 13. PMID: 27470359
Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

6-shogaol induces autophagic cell death then triggered apoptosis in colorectal cancer cells. Aug 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Sep ;93:208-217. Epub 2017 Jun 20. PMID: 28641163
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest
[+]

6-shogaol induces cancer cell death by inducing G2/M cell cycle arrest and apoptosisDec 31, 2014

Pubmed Data : Am J Chin Med. 2015 ;43(4):743-56. Epub 2015 Jun 28. PMID: 26119958
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Tumor Suppressor Protein p53 Upregulation
[+]

6-Shogaol inhibits breast cancer cells and stem cell-like spheroids.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(9):e0137614. Epub 2015 Sep 10. PMID: 26355461
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Breast Cancer
Pharmacological Actions : Autophagy Up-regulation
Additional Keywords : Cancer Stem Cells
[+]

6-shogaol inhibits oxidative stress-induced rat vascular smooth muscle cell apoptosis.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Mol Biosci. 2022 ;9:808162. Epub 2022 Jan 31. PMID: 35174215
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Atherosclerosis, Cardiovascular Diseases
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective
[+]

6-shogaol inhibits the cell migration of colon cancer.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Cancer Ther. 2023 ;22:15347354231172732. PMID: 37157810
Article Published Date : Dec 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Colon Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, NF-kappaB Inhibitor
[+]

6-Shogaol inhibits the proliferation, apoptosis, and migration of rheumatoid arthritis fibroblast-like synoviocytes. Dec 31, 2022

Pubmed Data : Phytomedicine. 2023 Jan ;109:154562. Epub 2022 Nov 20. PMID: 36610124
Article Published Date : Dec 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Arthritis, Rheumatoid Arthritis
Pharmacological Actions : Antiproliferative , Apoptotic, NF-kappaB Inhibitor
[+]

6-shogaol is a novel functional agent capable of preventing DMBA induced inflammation and cell proliferation associated tumorigenesis.Dec 25, 2017

Pubmed Data : Biomed Pharmacother. 2017 Dec 26 ;98:484-490. Epub 2017 Dec 26. PMID: 29287195
Article Published Date : Dec 25, 2017
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Oral Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive
[+]

6-shogaol is a novel potential therapeutic agent for the treatment of various neurodegenerative diseases, including Alzheimer's disease.Aug 11, 2016

Pubmed Data : Biochem Biophys Res Commun. 2016 Aug 12 ;477(1):96-102. Epub 2016 Jun 7. PMID: 27286707
Article Published Date : Aug 11, 2016
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Alzheimer's Disease, Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
[+]

6-shogaol may act against the apoptosis resistant cancer cells.Mar 14, 2018

Pubmed Data : Exp Cell Res. 2018 Mar 15 ;364(2):243-251. Epub 2018 Feb 17. PMID: 29462602
Article Published Date : Mar 14, 2018
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Breast Cancer, Lung Cancer
Pharmacological Actions : Apoptotic, Paraptosis
[+]

6-Shogaol may have potential as a chemopreventive or a therapeutic agent for prostate cancer.May 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Prev Res (Phila). 2014 Jun ;7(6):627-38. Epub 2014 Apr 1. PMID: 24691500
Article Published Date : May 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemopreventive, MicroRNA modulator, NF-kappaB Inhibitor, STAT3 Inhibitor
Additional Keywords : Gene Expression Regulation, Plant Extracts
[+]

6-shogaol overcomes gefitinib resistance via ER stress in ovarian cancer cells.Jan 29, 2023

Pubmed Data : Int J Mol Sci. 2023 Jan 30 ;24(3). Epub 2023 Jan 30. PMID: 36768961
Article Published Date : Jan 29, 2023
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Ovarian Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer
[+]

6-shogaol prevents UVB radiation mediated inflammation and oxidative stress through modulating NrF2 signalling in human epidermal keratinocytes.Jul 31, 2019

Pubmed Data : J Photochem Photobiol B. 2019 Aug ;197:111518. Epub 2019 May 31. PMID: 31202076
Article Published Date : Jul 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Inflammation, Oxidative Stress, Ultraviolet Radiation Induced Damage
Therapeutic Actions : Sunlight exposure
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Nrf2 activation, Photoprotective
[+]

6-shogaol protects human melanocytes against oxidative stress through activation of the Nrf2-antioxidant response element signalling pathway. May 15, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 May 16 ;21(10). Epub 2020 May 16. PMID: 32429495
Article Published Date : May 15, 2020
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Skin Diseases, Vitiligo
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS.Nov 20, 2018

Pubmed Data : Int J Mol Med. 2018 Nov 21. Epub 2018 Nov 21. PMID: 30483736
Article Published Date : Nov 20, 2018
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer, Tumor Suppressor Protein p53 Upregulation
[+]

6-shogaol suppresses induced human 786-O renal cell carcinoma osteoclastogenic activity and metastatic potential.Sep 27, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Sep 28 ;11(10). Epub 2019 Sep 28. PMID: 31569368
Article Published Date : Sep 27, 2019
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Kidney Cancer
Pharmacological Actions : Anti-metastatic
[+]

6-Shogaol suppresses the growth of breast cancer cells.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Aug ;128:110302. Epub 2020 Jun 5. PMID: 32505819
Article Published Date : Jul 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

6-shogaol suppresses the progression of liver cancer.Dec 31, 2020

Pubmed Data : Am J Chin Med. 2021 ;49(8):2033-2048. PMID: 34961414
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin pathway down-regulation
[+]

6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion. Dec 01, 2010

Pubmed Data : Br J Pharmacol. 2010 Dec ;161(8):1763-77. PMID: 20718733
Article Published Date : Dec 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Breast Cancer, Breast Cancer: Metastatic, Cancer Metastasis
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
[+]

A review of ginger in the prevention of ageing and degenerative diseases.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:5054395. Epub 2019 Aug 20. PMID: 31531114
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : 6-Shogaol, Ginger, Gingerol
Diseases : Aging, Alzheimer's Disease, Hypertension, Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

A review of targeting oncogenic transcription factors by polyphenols.Jan 03, 2018

Pubmed Data : Pharmacol Res. 2018 Jan 4. Epub 2018 Jan 4. PMID: 29305909
Article Published Date : Jan 03, 2018
Study Type : Review
Additional Links
Substances : 4-Shogaol, 6-Shogaol, Apigenin, Berberine, Caffeic Acid, Capsaicin, Cardamonin, Chrysin, Curcumin, EGCG (Epigallocatechin gallate), Ellagic Acid, Fisetin, Gingerol , Luteolin, Mangiferin, Piperlongumine , Polyphenols, Pterostilbene, Quercetin, Resveratrol, Rutin, Sesamin, Ursolic Acid, Wogonin, Xanthohumol
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive, Chemotherapeutic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, NF-kappaB Inhibitor, STAT3 Inhibitor, Wnt/β-catenin signaling pathway modulation
[+]

Anti-survival and pro-apoptotic effects of 6-shogaol on SW872 human liposarcoma cells.Sep 27, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2020 Sep 28 ;10(10). Epub 2020 Sep 28. PMID: 32998376
Article Published Date : Sep 27, 2020
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Liposarcoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Antifungal and anti-biofilm effects of 6-shogaol against Candida auris.Sep 26, 2020

Pubmed Data : J Appl Microbiol. 2020 Sep 27. Epub 2020 Sep 27. PMID: 32981148
Article Published Date : Sep 26, 2020
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Candida Infection
Pharmacological Actions : Anti-fungal effects
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation
[+]

Benefits of ginger and Its constituent 6-shogaol in inhibiting inflammatory processes.Jun 14, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2021 Jun 15 ;14(6). Epub 2021 Jun 15. PMID: 34203813
Article Published Date : Jun 14, 2021
Study Type : Review
Additional Links
Substances : 6-Shogaol, Ginger
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Blood-brain barrier permeability study of ginger constituents.Aug 18, 2019

Pubmed Data : J Pharm Biomed Anal. 2019 Aug 19 ;177:112820. Epub 2019 Aug 19. PMID: 31476432
Article Published Date : Aug 18, 2019
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol, Ginger, Gingerol
Diseases : Alzheimer's Disease, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Blood Brain Barrier
[+]

Cardioprotective effect of 6-shogaol against hyperglycemia-induced toxicity in H9c2 cardiomyocytes.Dec 31, 2018

Pubmed Data : Pak J Pharm Sci. 2019 Jan ;32(1(Supplementary)):327-331. PMID: 30829211
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Cardiomyopathy, Hyperglycemia
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective
[+]

Cytotoxic effect of 6-Shogaol in Imatinib sensitive and resistant K562 cells.Jan 31, 2021

Pubmed Data : Mol Biol Rep. 2021 Feb ;48(2):1625-1631. Epub 2021 Jan 30. PMID: 33515349
Article Published Date : Jan 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Acute Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Effects of 6-shogaol on glucose uptake and intestinal barrier integrity in Caco-2 cells.Jan 20, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2023 Jan 21 ;12(3). Epub 2023 Jan 21. PMID: 36766032
Article Published Date : Jan 20, 2023
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Hyperglycemia
Pharmacological Actions : Alpha-glucosidase inhibitor , Gastrointestinal Agents, Hypoglycemic Agents
[+]

Ginger constituent 6-shogaol inhibits inflammation and angiogenesis-related cell functions in primary human endothelial cells.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:844767. Epub 2022 Feb 25. PMID: 35281937
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents
[+]

Ginger extract activates caspase independent paraptosis in cancer cells.Nov 04, 2019

Pubmed Data : Nutr Cancer. 2019 Nov 5:1-13. Epub 2019 Nov 5. PMID: 31690139
Article Published Date : Nov 04, 2019
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol, Ginger
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Paraptosis
[+]

Ginger extracts, including the water extract possess the antioxidant activities to inhibit human LDL oxidation in vitro.Mar 31, 2014

Pubmed Data : J Med Food. 2014 Apr ;17(4):424-31. Epub 2014 Jan 9. PMID: 24404979
Article Published Date : Mar 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol, Ginger
Diseases : Cholesterol: Oxidation
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Ginger phytochemicals inhibit cell growth and modulate drug resistance factors in docetaxel resistant prostate cancer cells.Sep 04, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2017 Sep 5 ;22(9). Epub 2017 Sep 5. PMID: 28872603
Article Published Date : Sep 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol, Ginger, Gingerol
Diseases : Cancers: Drug Resistant, Prostate Cancer
Pharmacological Actions : Antiproliferative , Chemotherapeutic
[+]

In this review, the evidences for the chemopreventive and chemotherapeutic potential of ginger extract and its active components using in vitro, animal models, and patients have been described.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gastroenterol Res Pract. 2015 ;2015:142979. Epub 2015 Mar 8. PMID: 25838819
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : 6-Shogaol, Ginger, Gingerol
Diseases : Cancers: All, Gastrointestinal Cancer
Pharmacological Actions : Anti-metastatic, Anticarcinogenic Agents, Apoptotic, Chemopreventive, Chemotherapeutic
Additional Keywords : Significant Treatment Outcome
[+]

In vivo and in vitro studies have established that phenolic components of ginger induce apoptosis and autophagy and inhibit metastasis.Jun 07, 2016

Pubmed Data : Curr Pharm Des. 2016 Jun 8. Epub 2016 Jun 8. PMID: 27290916
Article Published Date : Jun 07, 2016
Study Type : Review
Additional Links
Substances : 6-Shogaol, Ginger, Gingerol
Diseases : Cancer Metastasis, Cancers: All
Pharmacological Actions : Anti-metastatic, Apoptotic, Autophagy Inhibitors
[+]

Influence of 6-shogaol potentiated on 5-fluorouracil treatment of liver cancer.Apr 30, 2022

Pubmed Data : Chin J Nat Med. 2022 May ;20(5):352-363. PMID: 35551770
Article Published Date : Apr 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Cancers: Drug Resistant, Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Mechanism study of 6-shogaol alleviating cerebral ischemia/reperfusion injury.May 31, 2024

Pubmed Data : Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2024 Jun ;36(6):616-623. PMID: 38991961
Article Published Date : May 31, 2024
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Brain Ischemia
Pharmacological Actions : Neuroprotective Agents
[+]

Metabolites of [6]-shogoal can account for the bioactivity of the parent compound, and specifically triggers molecular pathways responsible for cancer cell death in a similar fashion.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(1):e54677. Epub 2013 Jan 30. PMID: 23382939
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol, Ginger, Gingerol
Diseases : Colon Cancer, Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemopreventive
Additional Keywords : Metabolites
[+]

Phytochemicals may serve as novel therapeutic agents for breast cancer treatment.Sep 30, 2016

Pubmed Data : Semin Cancer Biol. 2016 Oct ;40-41:192-208. Epub 2016 Sep 5. PMID: 27609747
Article Published Date : Sep 30, 2016
Study Type : Review
Additional Links
Substances : 6-Shogaol, Celastrol, Curcumin, EGCG (Epigallocatechin gallate), Epicatechin, Genistein, Indole-3-Carbinol, Isoliquiritigenin, Parthenolide, Pterostilbene, Quercetin, Resveratrol, Sulforaphane, Triptolide, Vitamin E
Diseases : Breast Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Cancer Stem Cells
[+]

Pterostilbene and 6-shogaol exhibit inhibitory effects on sunitinib resistance and motility in renal cancer cells.Feb 04, 2024

Pubmed Data : Eur J Pharmacol. 2024 Feb 5:176393. Epub 2024 Feb 5. PMID: 38325792
Article Published Date : Feb 04, 2024
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol, Pterostilbene
Diseases : Kidney Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer
[+]

Review of the anticancer properties of 6-shogaol: Mechanisms of action in cancer cells and future research opportunities.Jun 30, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Sci Nutr. 2024 Jul ;12(7):4513-4533. Epub 2024 Mar 27. PMID: 39055196
Article Published Date : Jun 30, 2024
Study Type : Review
Additional Links
Substances : 6-Shogaol
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Apoptotic
[+]

The antitumor effects of 6-shogaol are mediated through activation of PPARγ and imply that activation of PPARγ might be beneficial for breast and colon cancer treatment.Aug 08, 2013

Pubmed Data : Cancer Lett. 2013 Aug 9 ;336(1):127-39. Epub 2013 Apr 21. PMID: 23612072
Article Published Date : Aug 08, 2013
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Breast Cancer, Colon Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, NF-kappaB Inhibitor
[+]

The content of 6-shogaol is very low in fresh ginger, but significantly higher after steaming.Oct 17, 2015

Pubmed Data : Am J Chin Med. 2015 Oct 18:1-13. Epub 2015 Oct 18. PMID: 26477795
Article Published Date : Oct 17, 2015
Study Type : Review
Additional Links
Substances : 6-Shogaol, Ginger, Gingerol
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive
[+]

These findings provide further support for the use of 6-shogaol as a therapeutic agent in neurodegenerative disorders.Nov 30, 2013

Pubmed Data : Phytother Res. 2013 Dec ;27(12):1795-9. Epub 2013 Feb 11. PMID: 23401228
Article Published Date : Nov 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Neurodegenerative Diseases, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Neuritogenic, Neuroprotective Agents
[+]

These findings showed the potential effects of 6S and 6G on the prevention of protein glycation.Aug 05, 2015

Pubmed Data : Chem Res Toxicol. 2015 Aug 6. Epub 2015 Aug 6. PMID: 26247545
Article Published Date : Aug 05, 2015
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol, Ginger, Gingerol
Diseases : Advanced Glycation Endproduct (AGE) Formation, Diabetic Complications
Pharmacological Actions : Anti-Glycation Agents
Additional Keywords : Plant Extracts
[+]

These findings support 6-shogaol's clinical promise as a potential candidate for HCC therapyJun 19, 2015

Pubmed Data : Eur J Pharmacol. 2015 Jun 20 ;762:449-458. Epub 2015 Jun 20. PMID: 26101062
Article Published Date : Jun 19, 2015
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation, Cell cycle arrest
[+]

These results highlight the antibiofilm and antivirulence activities of 6-gingerol and 6-shogaol, against a drug resistant C. albicans strain.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Infect Microbiol. 2018 ;8:299. Epub 2018 Aug 28. PMID: 30211127
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol, Gingerol
Diseases : Candida Albicans
Pharmacological Actions : Anti-Bacterial Agents
[+]

These results suggested that 6-shogaol inhibits AGEs-induced inflammatory responses.Oct 14, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Oct 15 ;24(20). Epub 2019 Oct 15. PMID: 31619000
Article Published Date : Oct 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Advanced Glycation End products (AGE), Diabetes Mellitus: Type 2, Periodontitis
Pharmacological Actions : Anti-Glycation Agents, Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation
[+]

These studies suggest ginger and 6-shogaol have the potential to combat asthma.Dec 03, 2019

Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 2019 Dec 4. Epub 2019 Dec 4. PMID: 31800263
Article Published Date : Dec 03, 2019
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Asthma, Lung Inflammation
Pharmacological Actions : Anti-Asthmatic Agents

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