Alpha-Lipoic Acid

Name	AC	CK
Inflammation	11	108
Diabetes Mellitus: Type 2	13	97
Oxidative Stress	21	73
C-Reactive Protein	5	70
Obesity	9	67
Carpal Tunnel Syndrome	5	50
Diabetic Neuropathy	6	34
Alzheimer's Disease	9	33
Cardiovascular Diseases	4	31
Burning Mouth Syndrome	3	30
Insulin Resistance	7	28
Hypertension	4	26
Diabetic Neuropathies	5	25
Metabolic Diseases	2	22
Metabolic Syndrome X	2	22
Chemotherapy-Induced Toxicity: Cisplatin	7	21
Endothelial Damage	2	21
Schizophrenia	3	21
Aging Skin	2	20
Chemotherapy-Induced Toxicity: Peripheral Neuropathy	2	20
Hepatitis C	2	20
Pancreatic Cancer	2	20
Peripheral Neuropathies	2	20
Polycystic Ovary Syndrome	2	20
Thalassemia	2	20
Endothelial Dysfunction	5	18
Cognitive Decline/Dysfunction	4	15
Diabetes: Cardiovascular Illness	4	15
Chemotherapy and Radiation Toxicity	3	14
Infertility: Male	3	14
Parkinson's Disease	3	13
Brain Inflammation	3	12
Chemically-Induced Liver Damage	6	12
Diabetes Mellitus: Type 1	2	12
Iron Overload	2	12
Multiple Sclerosis	3	12
Myocardial Infarction	2	12
Neuropathic Pain	2	12
Atrial Fibrillation	2	11
Infertility: Female	2	11
Migraine Disorders	2	11
Adiponectin: Low Levels	1	10
Athletic Performance	1	10
Back Pain	1	10
Brain Damage	1	10
Chemotherapy-Induced Toxicity: Paclitaxel	1	10
Chronic Pelvic Pain Syndrome	1	10
Coronary Artery Disease	1	10
Depression	1	10
Down Syndrome	1	10
Gestational Diabetes	1	10
Head Injuries	1	10
Hemodialysis	1	10
Herniated Disc	1	10
Homocystinuria	1	10
Hyperinsulinism	1	10
Interstitial Cystitis	1	10
Liver Cancer	1	10
Low Back Pain	1	10
Macular Degeneration	1	10
Multiple Myeloma	1	10
Overweight	1	10
Peripheral Arterial Disease	1	10
Pesticide Toxicity	5	10
Polyneuropathies	1	10
Prediabetes	1	10
Prostatitis: Chronic	1	10
Sciatic Neuralgia	1	10
Sciatica	1	10
Skin Diseases: Photo-Aging	1	10
Slipped Disk	1	10
Smell Disorders	1	10
Traumatic Brain Injury	1	10
Varicocele	1	10
Hearing Loss	5	9
High Fructose Diet	4	8
Phthalate Toxicity	2	7
Testicular Injury: Chemical/Metal Induced	4	7
Drug Toxicity: Methotrexate	3	6
High Fat Diet	3	6
Radiation	3	6
Amyotrophic lateral sclerosis (ALS)	2	5
Graves Disease	1	5
Mitochondrial Diseases	3	5
Prostate Cancer	1	5
Acetaminophen (Tylenol) Toxicity	2	4
Aging: Brain	2	4
Alcohol Toxicity	2	4
Breast Cancer	4	4
Diabetic Complications	2	4
Diabetic Retinopathy	3	4
Drug-Induced Toxicity: Methotrexate	2	4
Fetal Origin of Adult Disease	2	4
Glyphosate Toxicity	2	4
Liver Fibrosis	2	4
Mitochondrial Dysfunction	3	4
Spinal Cord Injuries	2	4
Aging	2	3
Amyotrophic Lateral Sclerosis	2	3
Cardiomyopathy	2	3
Cholesterol: Oxidation	3	3
Coronavirus Infection	2	3
Kidney Cancer	1	3
Memory Disorders	2	3
Mercury Poisoning	2	3
Aluminum Toxicity	1	2
Aortic Calcification	1	2
Ascites	1	2
Atherosclerosis	1	2
Autism	1	2
Bisphenol Toxicity	1	2
Bisphenol-A Toxicity	1	2
Chemotherapy	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Bleomycin	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Chemotherapy-Induced Toxicity: Irinotecan	1	2
Chemotherapy-Induced Toxicity: Oxaliplatin	1	2
Chronic Hepatitis	1	2
Circadian Dysregulation	1	2
DNA damage	1	2
Diabetes Mellitus: Type 2: Prevention	1	2
Drug-Induced Toxicity: Gastrointestinal	1	2
Dyslipidemias	1	2
Ectopic Calcification	1	2
Fatty Liver	1	2
Fluoride Toxicity	1	2
Fructose-Induced Toxicity	1	2
Glomerulonephritis	1	2
Heart Failure	1	2
Heavy Metal Toxicity	1	2
Hepatitis: Lectin-Induced (concanavalin)	1	2
Hyperglycemia	1	2
Hyperlipidemia	1	2
Hyperuricemia	1	2
Hypoxia	1	2
Kidney Damage	1	2
Kidney Damage: Antibiotic-Induced	1	2
Kidney Damage: Chemically-Induced	1	2
Lipid Peroxidation	1	2
Liver Damage: Drug-Induced	1	2
Lung Cancer	2	2
Membranoproliferative glomerulonephritis (MPGN)	1	2
Memory Loss	1	2
Muscle Disorders	1	2
Nephrocalcinosis	1	2
Neurodevelopmental Disorders	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Opiate Addiction/Withdrawal	1	2
Oral Mucositis	1	2
Osteoarthritis	1	2
Osteoporosis	2	2
Pesticide Toxicity: Cypermethrin	1	2
Pesticide-Induced Toxicity: Organochlorines	1	2
Pesticide-Induced Toxicity: Organophosphates	1	2
Postmenopausal Disorders	1	2
Postmenopausal Disorders: Weight Gain/Obesity	1	2
Pulmonary Fibrosis	1	2
Radiation Induced Illness	1	2
Radiation Induced Illness: Bone Marrow	1	2
Radiation Induced Illness: Enteritis	1	2
Radiation-Induced Illness: Radioiodine (Iodine-131)	1	2
Sciatic Nerve Crush Injury	1	2
Sleep Apnea	1	2
Statin-Induced Pathologies	1	2
Stroke: Ischemic	1	2
Testicular Diseases	1	2
Triglycerides: Elevated	1	2
Arsenic Poisoning	1	1
Brain Injury: Traumatic	1	1
Cancers: All	1	1
Cardiac Arrhythmias	1	1
Cardiac Hypertrophy	1	1
Chemotherapy-Induced Kidney Damage	1	1
Colorectal Cancer	1	1
Copper Toxicity	1	1
Coronavirus Disease	1	1
Diabetic Nephropathy	1	1
Drug-Induced Toxicity: Cyclosporine	1	1
Dry Eye Syndromes	1	1
Encephalomyelitis	1	1
Endometriosis	1	1
Gastric Cancer	1	1
Glioblastoma	1	1
Glutathione Deficiency	1	1
Learning disorders	1	1
Leukemia	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Nerve Compression Syndromes	1	1
Neurodegenerative Diseases	1	1
Parkinsonism	1	1
Sepsis	1	1
Sickle Cell Anemia	1	1

Name	AC	CK
Antioxidants	87	291
Anti-Inflammatory Agents	41	179
Neuroprotective Agents	35	118
Hypolipidemic	8	57
Hypoglycemic Agents	4	50
Malondialdehyde Down-regulation	8	48
Chemoprotective Agents	12	39
Tumor Necrosis Factor (TNF) Alpha Inhibitor	7	39
Interleukin-6 Downregulation	5	36
Superoxide Dismutase Up-regulation	4	32
Cardioprotective	6	28
Anti-Apoptotic	14	27
Hepatoprotective	13	26
Analgesics	3	22
Antihypertensive Agents	2	22
Renoprotective	8	22
Radioprotective	8	16
Interleukin-10 upregulation	3	14
NF-kappaB Inhibitor	7	13
Interleukin-17 downregulation	2	12
Vasodilator Agents	2	12
Fertility Agents: Female	2	11
Insulin Sensitizers	2	11
Adiponectin upregulation	1	10
Fertility Agents: Male	1	10
Neurogenesis	1	10
Neurorestorative	1	10
Vascular Endothelial Growth Factor Regulator	1	10
cAMP up-regulation	1	10
Nrf2 activation	4	7
Anti-Adipogenic	1	5
Chemotherapeutic	3	5
Cyclooxygenase 2 Inhibitors	3	5
Heme oxygenase-1 up-regulation	3	5
Apoptotic	4	4
Chemopreventive	2	4
Gastroprotective	2	4
Interleukin-1 beta downregulation	3	4
Anti-metastatic	3	3
Antiproliferative	3	3
Cytoprotective	2	3
Adenosine Monophosphate (AMP)-Activated Protein Kinase (AMPK) Down-Regulation	1	2
Adiponectin Down-Regulation	1	2
Anti-Fibrotic	1	2
Anticholesteremic Agents	1	2
Antidiarrheals	1	2
Antioxidant	1	2
Chemosensitizer	2	2
Detoxifier	1	2
Fibroblast growth factor 21 upregulation	1	2
Heme oxygenase-1 inducer	1	2
Interleukin-1 alpha downregulation	1	2
Iron Chelating Agents	1	2
Leptin Down-Regulation	1	2
NF-E2-Related Factor-2 (Nrf2) Modulator	1	2
Osteoprotective	1	2
Pancreato Protective Agents	1	2
Radiosensitizer	2	2
Regenerative	1	2
Antiviral Agents	1	1
Autophagy Inhibitors	1	1
Autophagy Up-regulation	1	1
Brain-derived neurotrophic factor modulator	1	1
Caspase-3 Activation	1	1
Immunomodulatory	1	1
Immunostimulatory	1	1
Interleukin-18 down-regulation	1	1
Osteogenic	1	1
Phase II Detoxification Enzyme Inducer	1	1
RANK Downregulation	1	1
STAT3 Inhibitor	1	1

Pharmacological Actions : Hypolipidemic

Additional Keywords : Dose Response

[+]

The results showed that alpha-lipoic acid supplementation appears to improve the endothelial function.Nov 17, 2020

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Pubmed Data : Phytother Res. 2020 Nov 18. Epub 2020 Nov 18. PMID: 33205568

Article Published Date : Nov 17, 2020

Study Type : Meta Analysis, Review

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Endothelial Damage

Pharmacological Actions : Antioxidants

[+]

A triple antioxidant approach to the treatment of hepatitis C may be superior to traditional interferon and antiviral drug therapy. Oct 15, 1999

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Pubmed Data : Med Klin (Munich). 1999 Oct 15;94 Suppl 3:84-9. PMID: 10554539

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Pubmed Data : Br J Dermatol. 2003 Oct;149(4):841-9. PMID: 14616378

Article Published Date : Oct 01, 2003

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Aging Skin, Skin Diseases: Photo-Aging

[+]

ALA-R full dose administration for two months leads to positive short term results in terms of symptoms and function improvement.Feb 29, 2020

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Pubmed Data : Med Arh. 2008;62(1):45-8. PMID: 18543755

Article Published Date : Jan 01, 2008

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Diabetic Neuropathies

[+]

Pubmed Data : J Blood Med. 2020 ;11:131-139. Epub 2020 May 7. PMID: 32494211

Article Published Date : Dec 31, 2019

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Pubmed Data : Reprod Biomed Online. 2020 Dec ;41(6):1084-1091. Epub 2020 Aug 20. PMID: 33032908

Article Published Date : Nov 30, 2020

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Infertility: Male, Varicocele

Pharmacological Actions : Fertility Agents: Male

[+]

Alpha-lipoic acid may be a clinically useful therapy in interstitial cystitis.Jan 01, 2007

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Pubmed Data : Med Hypotheses. 2007;69(4):957-8. Epub 2007 Apr 23. PMID: 17451887

Alpha-lipoic acid, linoleic acid and echinacea proved to be an effective treatment for controlling symptoms and improving the evolution of carpal tunnel syndrome.May 31, 2015

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Pubmed Data : Int J Immunopathol Pharmacol. 2015 Jun ;28(2):256-62. Epub 2015 May 7. PMID: 25953494

Article Published Date : May 31, 2015

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid, Echinacea, Linoleic acid

Diseases : Carpal Tunnel Syndrome

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Antioxidants, Neurogenesis

Additional Keywords : Endogenous Cannabinoid, Significant Treatment Outcome

[+]

Baicalin capsules combined with α-lipoic acid are effective in treating patients with diabetic peripheral neuropathy.Dec 31, 2020

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Pubmed Data : Am J Transl Res. 2021 ;13(4):2774-2783. Epub 2021 Apr 15. PMID: 34017440

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Reprod Biomed. 2020 Dec ;18(12):1029-1038. Epub 2020 Dec 21. PMID: 33426413

Article Published Date : Nov 30, 2020

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Gestational Diabetes

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic

[+]

Efficacy and safety of the combination of superoxide dismutase, alpha lipoic acid, vitamin B12, and carnitine for 12 months in patients with diabetic neuropathy.Oct 22, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2020 Oct 23 ;12(11). Epub 2020 Oct 23. PMID: 33114210

Article Published Date : Oct 22, 2020

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid, Carnitine, Vitamin B-12

Diseases : Diabetic Neuropathy

Pharmacological Actions : Renoprotective

Additional Keywords : Risk Reduction

[+]

Homocysteine-lowering therapy may prevent bone loss in Parkinson's disease patients taking levodopa.Feb 15, 2010

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Pubmed Data : Mov Disord. 2010 Feb 15;25(3):332-40. PMID: 19938151

Article Published Date : Feb 15, 2010

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid, Vitamin B-12

Diseases : Homocystinuria, Parkinson's Disease

Pharmacological Actions : Antioxidants

Additional Keywords : Diseases that are Linked

[+]

Insulin-sensitizing effect and antioxidant action of alpha lipoic acid in oligomenorrheic women with polycystic ovary syndrome.Nov 25, 2021

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Pubmed Data : Minerva Obstet Gynecol. 2021 Nov 26. Epub 2021 Nov 26. PMID: 34825791

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Pubmed Data : J Hand Surg Am. 2017 Apr ;42(4):236-242. Epub 2017 Feb 28. PMID: 28249792

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Pubmed Data : Hum Fertil (Camb). 2022 Jan 13:1-9. Epub 2022 Jan 13. PMID: 35023797

Article Published Date : Jan 12, 2022

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Infertility: Male

Pharmacological Actions : Fertility Agents: Male

[+]

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Pubmed Data : Trials. 2019 Jun 10 ;20(1):345. Epub 2019 Jun 10. PMID: 31182153

Pubmed Data : Eur J Clin Nutr. 2014 Oct ;68(10):1119-23. Epub 2014 Jun 18. PMID: 24939437

Article Published Date : Sep 30, 2014

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid, Vitamin E: alpha tocopherol

Diseases : Down Syndrome, Oxidative Stress

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation

Additional Keywords : Supplementation

[+]

Alpha-lipoic acid could be a therapeutic agent because of its inhibitory effects on ROS production, inflammation, and adipose tissue expansionDec 31, 2015

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Pubmed Data : Medicine (Baltimore). 2016 Jan ;95(2):e2497. PMID: 26765462

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Pubmed Data : Complement Med Res. 2017 ;24(3):175-181. Epub 2017 Jun 12. PMID: 28641283

Article Published Date : Dec 31, 2016

Study Type : Human: Case Report

Additional Links

Substances : Alpha-Lipoic Acid, Selenium

Diseases : Amyotrophic lateral sclerosis (ALS)

Therapeutic Actions : Dietary Modification: Vegetarian

Additional Keywords : Significant Treatment Outcome

Problem Substances : Mercury

[+]

"Lipoic acid mitigates bisphenol A-induced testicular mitochondrial toxicity in rats."May 23, 2012

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Pubmed Data : Toxicol Ind Health. 2012 May 23. Epub 2012 May 23. PMID: 22623521

Article Published Date : May 23, 2012

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Bisphenol-A Toxicity, Testicular Diseases

Problem Substances : Bisphenol A

Adverse Pharmacological Actions : Endocrine Disruptor: Testes

[+]

A combination of gamma linolenic acid and alpha lipoic acid is effective against multiple indices of experimental diabetic neuropathy.Jul 01, 1998

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Pubmed Data : Diabetologia. 1998 Jul;41(7):839-43. PMID: 9686927

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Pubmed Data : Indian J Exp Biol. 2010 Feb;48(2):150-8. PMID: 20455324

Article Published Date : Feb 01, 2010

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid, Resveratrol, Vitamin C, Vitamin E

Diseases : Pesticide Toxicity

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords : Stilbenes

[+]

A light microscopic investigation of the renoprotective effects of α-lipoic acid and α-tocopherol in an experimental diabetic rat model.Feb 03, 2020

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Pubmed Data : Biotech Histochem. 2020 Feb 4:1-12. Epub 2020 Feb 4. PMID: 32013590

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Pubmed Data : Z Gerontol Geriatr. 2019 Oct 10. Epub 2019 Oct 10. PMID: 31602508

Pubmed Data : Pharmacology. 2008;81(2):173-80. Epub 2007 Nov 19. PMID: 18025842

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Alcohol Toxicity

[+]

Alpha lipoic acid decreases neuronal damage on brain tissue of STZ-induced diabetic rats.Apr 30, 2022

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Pubmed Data : Physiol Behav. 2022 May 1 ;248:113727. Epub 2022 Feb 4. PMID: 35131301

Article Published Date : Apr 30, 2022

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Diabetic Complications, Diabetic Neuropathy

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

Alpha lipoic acid had ameliorative effects against HFCS induced pancreatic lesions.Mar 09, 2016

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Pubmed Data : Pancreatology. 2016 Mar 10. Epub 2016 Mar 10. PMID: 27025195

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Pubmed Data : Environ Toxicol Pharmacol. 2018 Feb 23 ;59:17-23. Epub 2018 Feb 23. PMID: 29500983

Article Published Date : Feb 22, 2018

Alpha-lipoic acid alleviates NAFLD and triglyceride accumulation in liver.Apr 30, 2021

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Pubmed Data : Vet World. 2020 May ;13(5):963-966. Epub 2020 May 22. PMID: 32636594

Article Published Date : Apr 30, 2020

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Alpha-lipoic acid and carnitine had a beneficial role in the prevention of MS associated with development of type 2 diabetes.Aug 04, 2016

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Pubmed Data : J Diet Suppl. 2016 Aug 5:1-11. Epub 2016 Aug 5. PMID: 27494173

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Pubmed Data : Neurotox Res. 2021 Mar 10. Epub 2021 Mar 10. PMID: 33689146

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Pubmed Data : Biol Pharm Bull. 2019 ;42(9):1456-1463. PMID: 31474707

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Endothelial Dysfunction, High Fat Diet

Pharmacological Actions : Antioxidants, Vasodilator Agents

[+]

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Hum Exp Toxicol. 2015 Mar 29. Epub 2015 Mar 29. PMID: 25825413

Article Published Date : Mar 28, 2015

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Endothelial Dysfunction, Inflammation, Oxidative Stress

Pharmacological Actions : Cardioprotective

Additional Keywords : Increased Risk, Risk Reduction

Problem Substances : High Fructose Corn Syrup

Adverse Pharmacological Actions : Cardiotoxic

[+]

Alpha-lipoic acid reduces retinal cell death in diabetic mice.Jul 10, 2018

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Pubmed Data : Biochem Biophys Res Commun. 2018 Jul 11. Epub 2018 Jul 11. PMID: 30017190

Article Published Date : Jul 10, 2018

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Diabetic Retinopathy

Pharmacological Actions : Anti-Apoptotic

[+]

Alpha-lipoic acid strongly reduced AgNP-induced side effects without weakening the therapeutic efficacy.Sep 23, 2021

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Pubmed Data : Fish Shellfish Immunol. 2021 Oct 12 ;119:249-261. Epub 2021 Oct 12. PMID: 34653663

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Pubmed Data : Biotech Histochem. 2019 Jan 11:1-6. Epub 2019 Jan 11. PMID: 30632398

Article Published Date : Jan 10, 2019

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Chemically-Induced Liver Damage, High Fructose Diet

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective

Problem Substances : High Fructose Corn Syrup

[+]

EPA and lipoic acid reduce kidney and aortic ectopic calcification in rats. Sep 01, 1998

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Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 1998 Sep;59(3):221-7. PMID: 9844996

Article Published Date : Sep 01, 1998

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid, Eicosapentaenoic acid (EPA) , EPA (Eicosapentaenoic Acid)

Diseases : Aortic Calcification, Ectopic Calcification, Nephrocalcinosis

[+]

Hepatoprotective actions of ascorbic acid, alpha lipoic acid and silymarin or their combination against acetaminophen-induced hepatotoxicity in rats.May 20, 2019

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Pubmed Data : Medicina (Kaunas). 2019 May 21 ;55(5). Epub 2019 May 21. PMID: 31117289

Article Published Date : May 20, 2019

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid, Silibinin, Vitamin C

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidant, Hepatoprotective

Additional Keywords : Natural Substance Synergy

Problem Substances : Acetaminophen, Paracetamol

[+]

Impact of alpha-lipoic acid chronic discontinuous treatment in cardiometabolic disorders and oxidative stress induced by fructose intake in rats.Dec 10, 2019

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Pubmed Data : Antioxidants (Basel). 2019 Dec 11 ;8(12). Epub 2019 Dec 11. PMID: 31835800

Article Published Date : Dec 10, 2019

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : High Fructose Diet, Hyperglycemia, Hypertension, Insulin Resistance, Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Lipoic acid attenuates hypertension and improves insulin sensitivity in high fructose-fed rats.Nov 01, 2004

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Pubmed Data : J Comp Physiol B. 2004 Nov;174(8):587-92. Epub 2004 Sep 29. PMID: 15565449

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Pubmed Data : Biochim Biophys Acta. 2016 Jan 6. Epub 2016 Jan 6. PMID: 26769360

Article Published Date : Jan 05, 2016

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Alzheimer's Disease, High Fat Diet

Pharmacological Actions : Neuroprotective Agents

[+]

Lipoic acid may have therapeutic value for obesity in postmenopausal women.Apr 18, 2011

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Pubmed Data : Menopause. 2011 Apr 18. Epub 2011 Apr 18. PMID: 21505371

Pubmed Data : Ecotoxicol Environ Saf. 2013 May ;91:129-38. Epub 2013 Mar 7. PMID: 23465731

Article Published Date : Apr 30, 2013

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid, Vitamin E: alpha tocopherol

Diseases : Glyphosate Toxicity, Infertility: Male

Pharmacological Actions : Antioxidants

Problem Substances : Glyphosate, Zineb

Adverse Pharmacological Actions : Endocrine Disruptor: Testes

[+]

Potential protective role of rutin and alpha-lipoic acid against cisplatin-induced nephrotoxicity.Dec 31, 2018

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Protective potentials of alpha-lipoic acid against ionizing radiation-induced brain damage.Dec 31, 2022

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Pubmed Data : Oxid Med Cell Longev. 2023 ;2023:4999306. Epub 2023 Feb 3. PMID: 36778212

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Oxidative Stress, Radiation

Pharmacological Actions : Antioxidants, Radioprotective, Superoxide Dismutase Up-regulation

[+]

Quercetin and α-lipoic acid complemented each other in protecting the rat brain against oxidative stress induced by aluminium chloride.Dec 31, 2017

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Pubmed Data : J Toxicol. 2018 ;2018:2817036. Epub 2018 May 16. PMID: 29861723

Article Published Date : Dec 31, 2017

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Pubmed Data : Int J Clin Exp Med. 2015 ;8(5):7689-700. Epub 2015 May 15. PMID: 26221319

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Pubmed Data : Front Neurosci. 2017 ;11:651. Epub 2017 Dec 1. PMID: 29249928

Article Published Date : Dec 31, 2016

Study Type : Animal Study

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Substances : Alpha-Lipoic Acid

Diseases : Alzheimer's Disease

Pharmacological Actions : Detoxifier, Neuroprotective Agents

Additional Keywords : Alpha-Lipoic Acid, Alzheimer's disease, Detoxifier, Gene Expression Regulation, Neuroprotective Agents

Problem Substances : Formaldehyde

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The effect of α-lipoic acid on oxidative stress in adipose tissue.May 06, 2022

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Vitamin E, acetyl-l-carnitine and α-lipoic acid are superior to the drug donepezil (Aricept) at normalizing biomarkers associated with Alzheimer's disease in an animal model. Dec 23, 2010

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Pubmed Data : Exp Toxicol Pathol. 2010 Dec 23. Epub 2010 Dec 23. PMID: 21183322

Article Published Date : Dec 23, 2010

Study Type : Animal Study

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Substances : Acetyl-l-carnitine, Alpha-Lipoic Acid, Vitamin E

Diseases : Alzheimer's Disease

Additional Keywords : Superiority of Natural Substances versus Drugs

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Vitamin E, vitamin C, resveratrol, and alpha-lipoic acid have a protective effect against insecticide-induced toxicity in mice. Jan 01, 2008

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Pubmed Data : Crit Care. 2008;12(6):R136. Epub 2008 Nov 6. PMID: 20663516

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Pubmed Data : Brain Res Bull. 2018 May 26 ;140:299-310. Epub 2018 May 26. PMID: 29842900

Article Published Date : May 25, 2018

Study Type : Insect Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Amyotrophic lateral sclerosis (ALS)

Pharmacological Actions : Antioxidants, Neuroprotective Agents

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α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway.Dec 31, 2018

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Pubmed Data : Cell Biol Int. 2020 Nov 26. Epub 2020 Nov 26. PMID: 33241887

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Pubmed Data : Sci Rep. 2020 Nov 24 ;10(1):20482. Epub 2020 Nov 24. PMID: 33235302

Article Published Date : Nov 23, 2020

Study Type : In Vitro Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Diabetes Mellitus: Type 2, Insulin Resistance

Pharmacological Actions : Antioxidants

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Alpha-lipoic acid exerts its antiviral effect against viral hemorrhagic septicemia virus.Sep 11, 2021

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Pubmed Data : Virol Sin. 2021 Sep 12. Epub 2021 Sep 12. PMID: 34510367

Article Published Date : Sep 11, 2021

Study Type : In Vitro Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Viral Hemorrhagic Septicemia virus (VHSV)

Pharmacological Actions : Antioxidants, Antiviral Agents

Additional Keywords : Gene Expression Regulation

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Pubmed Data : Environ Toxicol Pharmacol. 2020 Jan 7 ;75:103323. Epub 2020 Jan 7. PMID: 31935550

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Pubmed Data : Biofactors. 2016 Aug 10. Epub 2016 Aug 10. PMID: 27507611

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Pubmed Data : Mult Scler. 2015 Aug 18. Epub 2015 Aug 18. PMID: 26286700

Article Published Date : Aug 17, 2015

Study Type : Review

Additional Links

Substances : Alpha-Lipoic Acid, EGCG (Epigallocatechin gallate)

Diseases : Multiple Sclerosis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

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Piperlongumine and alpha lipoic acid may have a potential value as a therapeutic agent for patients with acute promyelocytic leukemia.Mar 31, 2016

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Pubmed Data : Crit Rev Food Sci Nutr. 2020 Dec 17:1-14. Epub 2020 Dec 17. PMID: 33327738

Article Published Date : Dec 16, 2020

Study Type : Review

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Cardiovascular Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Sulforaphane and alpha-lipoic acid upregulate the expression of the phase 2 liver detoxification enzyme glutathione S-transferase.Mar 01, 2010

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Pubmed Data : Int J Inflam. 2020 ;2020:5369797. Epub 2020 Apr 9. PMID: 32328233

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Alpha-Lipoic Acid, Coenzyme Q10

Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Antioxidants, Chemoprotective Agents, Renoprotective

[+]

Therapeutic benefits of alpha-lipoic acid supplementation in diabetes mellitus.Dec 22, 2021

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Pubmed Data : J Diet Suppl. 2021 Dec 23:1-21. Epub 2021 Dec 23. PMID: 34939534

Article Published Date : Dec 22, 2021

Study Type : Review

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Diabetes: Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor

[+]

Therapeutic potential of alpha-lipoic acid in viral infections, including COVID-19.Aug 15, 2021

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Pubmed Data : Antioxidants (Basel). 2021 Aug 16 ;10(8). Epub 2021 Aug 16. PMID: 34439542

Article Published Date : Aug 15, 2021

Study Type : In Vitro Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Coronavirus Infection, Hepatitis C

Pharmacological Actions : Antiviral Agents

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View the Evidence: 309 Abstracts with Alpha-Lipoic Acid Research

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A review of the effect of alpha-lipoic acid on inflammatory mediators.Apr 14, 2019

Alpha-lipoic acid administration may lead to an improvement in glucose homeostasis parameters and lipid profiles except HDL-cholesterol levels.Jul 06, 2018

Alpha-lipoic acid supplementation could significantly decrease CRP level in patients with elevated levels of this inflammatory marker.Apr 16, 2018

Alpha-lipoic acid supplementation had beneficial effects on inflammatory markers among patients with metabolic syndrome and related disorders.Dec 31, 2017

Alpha-Lipoic acid supplementation significantly reduces the risk of obesity.Feb 23, 2020

The current meta-analysis revealed that alpha-lipoic acid supplementation lowers BP in subjects, especially those with elevated BP.Feb 10, 2019

The present meta-analysis revealed the beneficial effects of ALA supplementation on TC, LDL and TG levels.Oct 03, 2021

The results showed that alpha-lipoic acid supplementation appears to improve the endothelial function.Nov 17, 2020

A triple antioxidant approach to the treatment of hepatitis C may be superior to traditional interferon and antiviral drug therapy. Oct 15, 1999

A multi antioxidative treatment in chronic hepatitis C virus patients is well tolerated and therapeutic. Sep 01, 2005

A multi-nutrient mixture of marine proteins, alpha-lipoic acid, pine bark extract, vitamins and minerals is safe and efficacious in the treatment of aging symptoms of the skin in women. May 01, 2005

A nutrient combination improves cognitive function in head injuried former NFL players. Jan 01, 2011

A topical cream containing 5% alpha-lipoic acid improves clinical symptoms of photoageing of facial skin. Oct 01, 2003

ALA-R full dose administration for two months leads to positive short term results in terms of symptoms and function improvement.Feb 29, 2020

Alpha Lipoic Acid confers pain relief in patients with Peripheral Arterial Disease. Aug 01, 2010

Alpha lipoic acid has a curative effect on peripheral neuropathy in type 2 diabetes. Oct 16, 2007

Alpha Lipoic Acid has therapeutic benefits in the treatment of diabetic neuropathy - Article 1Jan 01, 2008

Alpha lipoic acid is an anti-inflammatory and neuroprotective treatment for Alzheimer's disease. Oct 01, 2008

Alpha lipoic acid may be a promising supplement in the weight reduction in obese children and adolescents.Apr 03, 2020

Alpha lipoic acid may decrease the cardiovascular disease risk in type 2 diabetic patients.Dec 31, 2019

Alpha lipoic acid may provide an effective adjuvant in the treatment of metastatic and nonmetastatic pancreatic cancer.Dec 01, 2009

Alpha lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy.Dec 01, 2008

Alpha lipoic acid supplementation improved antioxidant enzyme activities in hemodialysis patients.Aug 31, 2019

Alpha lipoic acid therapy reduces serum levels of common markers of inflammation in ablated patients.Apr 30, 2017

Alpha lipoic appears to be an effective neuroprotective agent in Alzheimer's disease. Jan 01, 2007

Alpha lipoic has significant therapeutic value in the treatment of diabetic neuropathy. Nov 01, 2008

Alpha lipoic may have a profound therapeutic role in the treatment of pancreatic cancer. Mar 01, 2006

Alpha-lipoic acid administered 1 month before open decompression and afterward improves the clinical and neurophysiologic outcomes after surgery.Jan 21, 2018

Alpha-Lipoic acid and acetyl-L-carnitine appear to improve vascular function and blood pressure in patients with coronary artery disease. Apr 01, 2007

Alpha-lipoic acid and gamma-linolenic acid significantly improve symptom scores and functional impairment in patients with carpal tunnel syndrome. Mar 01, 2009

Alpha-lipoic acid as a means of influence on systemic inflammation in type 2 diabetes mellitus patients with prior myocardial infarction.Dec 31, 2019

Alpha-lipoic acid can improve plasma adiponectin levels and may play a potential role in the treatment of metabolic risk factor in patients with schizophrenia.Dec 31, 2016

Alpha-lipoic acid consumption can be an important complementary therapeutic option to prevent the progression of CVD in β-thalassemia major patients.Dec 31, 2019

Alpha-lipoic acid could prove useful as adjunctive therapy for schizophrenia.Oct 18, 2017

Alpha-lipoic acid improves hepatic metabolic dysfunctions in acute intermittent porphyria.Sep 05, 2021

Alpha-lipoic acid improves sperm motility in infertile men after varicocelectomy.Nov 30, 2020

Alpha-lipoic acid may be a clinically useful therapy in interstitial cystitis.Jan 01, 2007

Alpha-lipoic acid may have therapeutic benefits for burning mouth syndrome. - Article 1Sep 01, 2008

Alpha-lipoic acid may have therapeutic benefits for burning mouth syndrome. - Article 2Mar 01, 1999

Alpha-lipoic acid modifies circulating angiogenic factors in patients with type 2 diabetes mellitus.Jan 31, 2015

Alpha-lipoic acid or in combination with eicosapentaenoic acid modulates the inflammatory status of healthy overweight or obese women.Mar 08, 2016

Alpha-lipoic acid supplementation improves vascular tone and may have a beneficial effect on cardiovascular health in overweight/obese youths.Feb 11, 2019

Alpha-lipoic acid supplementation may be a useful strategy to improve insulin sensitivity in pre-diabetic subjects.Aug 31, 2019

Alpha-lipoic acid treatment improves vision-related quality of life in patients with dry age-related macular degeneration.Dec 31, 2015

Alpha-lipoic acid, linoleic acid and echinacea proved to be an effective treatment for controlling symptoms and improving the evolution of carpal tunnel syndrome.May 31, 2015

Baicalin capsules combined with α-lipoic acid are effective in treating patients with diabetic peripheral neuropathy.Dec 31, 2020

Benfotiamine and alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes. Oct 01, 2008

Combination of alpha lipoic acid and metformin supplement improve assisted reproductive technologies outcomes in polycystic ovary syndrome.May 02, 2022

Controlled-release alpha lipoic acid has a therapeutic effect in lean, nondiabetic patients with polycystic ovary syndrome.Mar 01, 2010

Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus.Nov 30, 2020

Efficacy and safety of the combination of superoxide dismutase, alpha lipoic acid, vitamin B12, and carnitine for 12 months in patients with diabetic neuropathy.Oct 22, 2020

Homocysteine-lowering therapy may prevent bone loss in Parkinson's disease patients taking levodopa.Feb 15, 2010

Insulin-sensitizing effect and antioxidant action of alpha lipoic acid in oligomenorrheic women with polycystic ovary syndrome.Nov 25, 2021

Lipoic acid combined with aerobic exercise inhibits lipid peroxidation in skeletal muscles.Jun 01, 2008

Lipoic acid down-regulates inflammation in multiple sclerosis patients.Jan 01, 2010

Lipoic acid improves diabetic neuropathy.Jan 01, 2007

Lipoic acid may be beneficial in preventing migraines.Jan 01, 2007

Lipoic acid may have therapeutic value in treating smell dysfunction following viral infection of the upper respiratory. Nov 01, 2002

Low-level laser therapy and alpha-lipoic acid are efficient therapies in reducing burning mouth symptoms.Mar 02, 2018

OPERA was able to improve CIPN symptoms in a prospective series of patients treated with neurotoxic chemotherapy.Feb 28, 2017

Oral 600mg alpha-lipoic acid twice daily treatment for diabetic peripheral neuropathy over 6 months is effective, safe and tolerable.May 04, 2020

Oral treatment with alpha-lipoic acid (ALA) and gamma-linolenic acid (GLA) for six weeks in synergy with rehabilitation therapy improved neuropathic symptoms and deficits in patients with radicular neuropathy.Jul 01, 2009

Palmitoylethanolamide and Alpha-lipoic acid are beneficial in treating patients with chronic prostatitis/chronic pelvic pain syndrome.Mar 30, 2017

Postoperative administration of alpha-lipoic acid for 40 days after median nerve decompression may result in a lower incidence of pillar pain.Mar 31, 2017

Supplementation of α-lipoic acid and myo-inositol in infertile obese women was associated with amelioration in the oxidative status of the oocyte environment.Nov 30, 2020

Supplementation with alpha-lipoic acid, carnosine, and thiamine supplement effectively reduced glucose concentration in type 2 diabetic patients.Nov 30, 2018

Supplementation with vitamin D3 plus antioxidants can prevent relapses in patients suffering from high recurrence-Benign paroxysmal positional vertigo.Aug 21, 2022

The effect of acetyl-L-carnitine, alpha-lipoic acid, and coenzyme Q10 combination in preventing anti-tuberculosis drug-induced hepatotoxicity.Dec 31, 2020

The effect of alpha lipoic acid supplementation on sperm functions in idiopathic asthenozoospermic patients.Jan 12, 2022

The effect of alpha-lipoic acid on diabetic peripheral neuropathy and the upcoming depressive disorders of type II diabetics.Jan 17, 2021

The effect of docosahexaenoic acid and α-lipoic acid as prevention of bortezomib-related neurotoxicity in patients with multiple myeloma.Dec 31, 2018

The effects of alpha lipoic acid on muscle strength recovery after a single and a short-term chronic supplementation.Nov 30, 2020

Alpha-Lipoic Acid

View the Evidence:
309 Abstracts with Alpha-Lipoic Acid Research