Andrographis

Name	AC	CK
Influenza	2	11
Cold and Flu	1	10
Common Cold	1	10
Familial Mediterranean Fever	1	10
Osteoarthritis: Knee	1	10
Respiratory Tract Infections	1	10
Rheumatoid Arthritis	1	10
Sinusitis	1	10
Upper Respiratory Infections	1	10
Liver Cancer	4	5
Cancer Metastasis	3	3
Cancers: All	3	3
Lymphoma	2	3
Avian Influenza	1	2
Chemically-Induced Liver Damage	1	2
Colon Cancer	2	2
Colorectal Cancer	2	2
Diabetic Nephropathy	1	2
Esophageal Cancer	1	2
H1N1 Infection	1	2
Immune Disorders: Low Immune Function	1	2
Influenza A	1	2
Kidney Diseases	1	2
Lymph Node Cancer	1	2
Malaria	1	2
Nephropathy: Diabetic	1	2
Pesticide Toxicity	1	2
Streptococcus Infections	1	2
Allergies	1	1
Cancer Stem Cells	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Diabetes Mellitus: Type 1	1	1
Epstein-Barr Virus Infections	1	1
Follicular Lymphoma	1	1
Gastric Cancer	1	1
H5N1 Infection	1	1
Inflammation	1	1
Lipopolysaccharide-Induced Toxicity	1	1
Lung Cancer	1	1
Multiple Myeloma	1	1
Multiple Sclerosis	1	1
Non-Hodgkin's lymphoma: B Cell	1	1
Promyelocytic leukemia	1	1
Prostate Cancer	1	1
Protozoan Infections	1	1
Rectal Cancer	1	1
Skin Cancer: Squamous Cell	1	1

Name	AC	CK
Analgesics	2	12
Immunomodulatory	4	6
Anti-metastatic	4	5
Apoptotic	5	5
Antineoplastic Agents	4	4
Antioxidants	2	4
Antiproliferative	2	3
Anti-Bacterial Agents	1	2
Anti-Inflammatory Agents	2	2
Anti-edemic	1	2
Anticarcinogenic Agents	1	2
Hepatoprotective	1	2
Renoprotective	1	2
Viral Hemagglutinin Inhibitor	1	2
Anti-Angiogenic	1	1
Antiprotozoal Agents	1	1
Antiviral Agents	1	1
Cell cycle arrest	1	1
Chemosensitizer	1	1
Epidermal growth factor receptor (EGFR) inhibitor	1	1
Insulin-releasing	1	1
Interleukin-6 Downregulation	1	1
Leukotriene Antagonists	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
NF-kappaB Inhibitor	1	1
Prostaglandin Antagonists	1	1
Thromboxane (TXB) Inhibitors	1	1
Tumor Necrosis Factor (TNF) Alpha Enhancer	1	1
Tumor Necrosis Factor (TNF) Alpha Inhibitor	1	1
Tumor Suppressor Protein p53 Upregulation	1	1

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A. paniculata significantly reduces fatigue in patients with relapsing-remitting multiple sclerosis receiving interferon beta.May 22, 2016

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Pubmed Data : BMC Neurol. 2016 May 23 ;16:77. Epub 2016 May 23. PMID: 27215274

Article Published Date : May 22, 2016

Study Type : Human Study

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Substances : Andrographis

Diseases : Fatigue, Multiple Sclerosis: Relapsing-Remitting

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Phytotherapy, Plant Extracts

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Andrographis extract was found to be effective and safe in reducing pain in individuals suffering from mild to moderate knee osteoarthritis.Apr 09, 2019

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Pubmed Data : Phytother Res. 2019 Apr 10. Epub 2019 Apr 10. PMID: 30968986

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Pubmed Data : Phytomed Plus. 2023 Feb ;3(1):100398. Epub 2022 Dec 20. PMID: 36570418

Article Published Date : Jan 31, 2023

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Pubmed Data : J Ayurveda Integr Med. 2021 Jul-Sep;12(3):529-534. Epub 2021 Aug 8. PMID: 34376353

Article Published Date : Jun 30, 2021

Study Type : Human Study

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Substances : Andrographis

Pharmacological Actions : Immunomodulatory

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Supplementation with a fixed combination of magnesium, vitamin B2, feverfew, Andrographis Paniculata and coenzyme Q10 for episodic migraine prophylaxis. Dec 26, 2020

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Pubmed Data : Phytomedicine. 2022 Jul 20 ;102:154183. Epub 2022 May 20. PMID: 35636176

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Pubmed Data : J Ethnopharmacol. 2016 Nov 4 ;192:170-177. Epub 2016 Jul 9. PMID: 27401291

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Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:8848797. Epub 2021 Mar 8. PMID: 33747115

Article Published Date : Dec 31, 2020

Study Type : Animal Study

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Substances : Andrographis

Diseases : Chronic Pain, Fever

Pharmacological Actions : Analgesics, Anti-pyretic

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Andrographis paniculata ameliorates carbon tetrachloride (CCl(4))-dependent hepatic damage and toxicity.Dec 31, 2010

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Pubmed Data : Biochim Biophys Acta. 2015 Apr ;1850(4):824-31. Epub 2015 Jan 29. PMID: 25641276

Article Published Date : Mar 31, 2015

Study Type : Animal Study

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Substances : Andrographis

Diseases : Diabetic Retinopathy

Pharmacological Actions : Anti-Angiogenic, Anti-Inflammatory Agents, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors

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Andrographolide ameliorates rheumatoid arthritis.Oct 10, 2019

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Pubmed Data : Int J Mol Sci. 2019 Oct 11 ;20(20). Epub 2019 Oct 11. PMID: 31614480

Article Published Date : Oct 10, 2019

Study Type : Animal Study

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Substances : Andrographis, Andrographolide

Diseases : Lipopolysaccharide-Induced Toxicity, Rheumatoid Arthritis

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents

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Andrographolide benefits rheumatoid arthritis via inhibiting MAPK pathways. Sep 30, 2017

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Pubmed Data : Inflammation. 2017 Oct ;40(5):1599-1605. PMID: 28584977

Article Published Date : Sep 30, 2017

Study Type : Animal Study

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Substances : Andrographis

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Andrographolide contributes to the attenuation of cardiac hypertrophy by suppressing endoplasmic reticulum stress.Nov 30, 2023

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Pubmed Data : Sci Rep. 2021 11 25 ;11(1):22904. Epub 2021 Nov 25. PMID: 34824314

Article Published Date : Jan 24, 2021

Study Type : Animal Study

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Substances : Andrographis

Diseases : Alzheimer's Disease

Pharmacological Actions : Neurogenesis, Neuroprotective Agents

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Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB.Dec 31, 2012

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Pubmed Data : PLoS One. 2013 ;8(2):e56407. Epub 2013 Feb 21. PMID: 23437127

Article Published Date : Dec 31, 2012

Study Type : Animal Study, In Vitro Study

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Substances : Andrographis

Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Andrographolide radiosensitizes human ovarian cancer SKOV3 xenografts due to an enhanced apoptosis and autophagy.Oct 31, 2015

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Pubmed Data : Tumour Biol. 2015 Nov ;36(11):8359-65. Epub 2015 May 28. PMID: 26014516

Article Published Date : Oct 31, 2015

Study Type : Animal Study

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Substances : Andrographis

Diseases : Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Radiosensitizer, Tumor Suppressor Protein p53 Upregulation

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Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease.Jan 09, 2016

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Pubmed Data : Indian J Med Res. 2012 Mar ;135:414-21. PMID: 22561631

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Pubmed Data : BMC Complement Altern Med. 2016 Nov 25 ;16(1):483. Epub 2016 Nov 25. PMID: 27887650

Article Published Date : Nov 24, 2016

Study Type : Animal Study

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Substances : Andrographis

Diseases : Pelvic Inflammatory Disease

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor

Additional Keywords : Phytotherapy

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The ethanol leaf extract of Andrographis paniculata blunts acute renal failure in cisplatin-induced injury.Nov 29, 2018

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Pubmed Data : J Basic Clin Physiol Pharmacol. 2018 Nov 30 ;30(2):205-217. Epub 2018 Nov 30. PMID: 30500779

Article Published Date : Nov 29, 2018

Study Type : Animal Study

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Substances : Andrographis

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Inflammation, Oxidative Stress

Pharmacological Actions : Antioxidants, Renoprotective

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The potential chemopreventive effect of Andrographis paniculata on 1,2-dimethylhydrazine and high-fat-diet-induced colorectal cancer.Mar 08, 2023

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Pubmed Data : Evid Based Complement Alternat Med. 2009 Sep 14. Epub 2009 Sep 14. PMID: 19752167

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Pubmed Data : Planta Med. 2014 May ;80(7):533-43. Epub 2014 Apr 29. PMID: 24782229

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Pubmed Data : Biochem Biophys Res Commun. 2020 Dec 10 ;533(3):467-473. Epub 2020 Aug 25. PMID: 32977949

Article Published Date : Dec 09, 2020

Study Type : In Vitro Study

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Substances : Andrographis

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

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Andrographolide as a potential inhibitor of SARS-CoV-2 main protease.Dec 31, 2020

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Pubmed Data : Proc Natl Acad Sci U S A. 2013 Jun 18 ;110(25):10201-6. Epub 2013 Jun 4. PMID: 23737504

Article Published Date : Jun 17, 2013

Study Type : In Vitro Study

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Substances : Andrographis

Diseases : Cancers: All

Pharmacological Actions : Anti-Inflammatory Agents

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Andrographolide effectively inhibits Epstein-barr virus.Nov 01, 2008

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Pubmed Data : Curr Mol Med. 2012 Sep ;12(8):952-66. PMID: 22804248

Andrographolide sensitizes Hep-2 human laryngeal cancer cells to carboplatin-induced apoptosis.Dec 31, 2018

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Pubmed Data : Anticancer Drugs. 2019 08 ;30(7):e0774. PMID: 31306153

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

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Substances : Andrographis

Diseases : Cancers: Drug Resistant, Laryngeal Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Antineoplastic Agents, Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Drug Synergy

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Published Date : Aug 01, 2009

Study Type : Review

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Substances : Andrographis

Additional Keywords : Plant Extracts

[+]

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Pubmed Data : Pharm Biol. 2012 Jul ;50(7):850-6. Epub 2012 May 16. PMID: 22587518

Article Published Date : Jun 30, 2012

Study Type : In Vitro Study

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Substances : Andrographis

Diseases : Aspergillosis, Candida Infection

Pharmacological Actions : Antifungal Agents

Additional Keywords : Plant Extracts

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This study illustrates the antiviral property of these Asian medicinal plants against the highly pathogenic avian H5N1 influenza virus.Aug 31, 2017

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Pubmed Data : Asian Pac J Trop Med. 2017 Sep ;10(9):871-876. Epub 2017 Sep 14. PMID: 29080615

Article Published Date : Aug 31, 2017

Study Type : In Vitro Study

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Substances : Andrographis, Guava, Gynostemma, Kaempferia parviflora, Turmeric

Diseases : H5N1 Infection, Influenza

Pharmacological Actions : Antiviral Agents

Additional Keywords : Plant Extracts

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View the Evidence: 186 Abstracts with Andrographis Research

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A. paniculata significantly reduces fatigue in patients with relapsing-remitting multiple sclerosis receiving interferon beta.May 22, 2016

Andrographis extract was found to be effective and safe in reducing pain in individuals suffering from mild to moderate knee osteoarthritis.Apr 09, 2019

Andrographis has a positive effect in the treatment of acute upper respiratory tract infections and also relieves the inflammatory symptoms of sinusitis.Oct 01, 2002

Andrographis has therapeutic activity against upper respiratory tract infections.Mar 01, 2010

Andrographis paniculate might be used as a potential natural drug for treating COVID-19.Jan 31, 2023

Andrographis reduces subjective and objective symptoms of rheumatoid arthritis. Aug 01, 2009

Andrographis, Eleutherococcus (Siberian Ginseng), Schisandra and Glycyrrhiza (Licorice) is safe and efficacious in the management of Familial Mediterranean Fever.Aug 01, 2008

Effect of Andrographis paniculata extract on triglyceride levels of the patients with hypertriglyceridemia.Jun 30, 2015

Immunomodulatory effects of Andrographis paniculata extract in healthy adults.Jun 30, 2021

Supplementation with a fixed combination of magnesium, vitamin B2, feverfew, Andrographis Paniculata and coenzyme Q10 for episodic migraine prophylaxis. Dec 26, 2020

The effect of Andrographis paniculata water extract on palliative management of metastatic esophageal squamous cell carcinoma.Jul 31, 2023

Andrographolide ameliorates aortic valve calcification.Jan 11, 2021

Andrographolide inhibits static mechanical pressure-induced intervertebral disc degeneration.Dec 31, 2022

Identification of active components in Andrographis paniculata targeting on CD81 in esophageal cancer in vitro and in vivo.Jul 19, 2022

A compound within Andrographis prevent diabetic nephropathy in an animal model. Aug 30, 2010

A standardised Andrographis paniculata Burm. Nees aqueous extract prevents Lipopolysaccharide-induced cognitive deficits.Feb 28, 2019

A. paniculata extract can be used for prevention and treatment of cardiovascular disease in obese patients.Nov 03, 2016

A. paniculata extracts significantly enhanced rate of wound healing.Dec 31, 2011

Activities of Andrographis paniculata tablet on Cox-2 and prostaglandin expression of placental of Plasmodium berghei infection.Dec 31, 2020

Analgesic and antipyretic activities of ethyl acetate fraction tablet of Andrographis paniculata.Dec 31, 2020

Andrographis and Hedyotis corymbosa in combination with curcumin have anti-malaria action.Feb 01, 2004

Andrographis does not appear to have any adverse effects on reproduction and fertility in male rats.Jul 01, 2009

Andrographis has a prophylactic effect against Streptococcus agalactiae infection in Nile tilapia.May 01, 2009

Andrographis has antioxidant, antioedema and analgesic activities.Jul 01, 2009

Andrographis has immunomodulatory activity. Jun 01, 2009

Andrographis may be more effective an anticancer agent than Doxorubicin in lymphoma. Dec 01, 2008

Andrographis paniculata ameliorates carbon tetrachloride (CCl(4))-dependent hepatic damage and toxicity.Dec 31, 2010

Andrographis paniculata ameliorates estrogen deficiency-related osteoporosis.Jan 30, 2023

Andrographis paniculata extract prevents development of murine colitis.Dec 31, 2012

Andrographis paniculata extract protect against isoproterenol-induced myocardial injury.Feb 29, 2012

Andrographis paniculata improves insulin resistance in high-fat diet-induced obesity.Dec 31, 2019

Andrographis paniculata leaf extract prevents thioacetamide-induced liver cirrhosis in rats.Dec 31, 2013

Andrographis paniculata mitigates first-line anti-tubercular drugs-induced nephrotoxicity.Mar 06, 2022

Andrographis paniculata protects against brain hippocampus and cerebellum from mercury chloride induced damage.Nov 30, 2022

Andrographis Paniculata shows anti-nociceptive effects in an animal model of sensory hypersensitivity associated with migraine.Dec 31, 2015

Andrographis paniculata was shown to possess anti-tumor, anti-metastatic and immunomodulatory activities in esophageal cancer cell.Mar 11, 2019

Andrographis paniculate could be used to improve PM2.5-induced lung injury by modulating the NF-κB pathway.Jul 12, 2021

Andrographolide ameliorates atherosclerosis by suppressing pro-inflammation and ROS generation-mediated foam cell formation.Sep 30, 2018

Andrographolide ameliorates d-galactosamine/lipopolysaccharide-induced acute liver injury by activating Nrf2 signaling pathway.Jun 19, 2017

Andrographolide ameliorates diabetic retinopathy by inhibiting retinal angiogenesis and inflammation.Mar 31, 2015

Andrographolide ameliorates rheumatoid arthritis.Oct 10, 2019

Andrographolide benefits rheumatoid arthritis via inhibiting MAPK pathways. Sep 30, 2017

Andrographolide contributes to the attenuation of cardiac hypertrophy by suppressing endoplasmic reticulum stress.Nov 30, 2023

Andrographolide inhibits inflammatory responses in LPS-stimulated macrophages and murine acute colitis.Jan 11, 2019

Andrographolide inhibits ovariectomy-induced bone loss.Nov 16, 2015

Andrographolide inhibits tumor angiogenesis via blocking VEGFA/VEGFR2-MAPKs signaling cascade.Jul 24, 2014

Andrographolide may have therapeutic value in the treatment of stroke.Sep 30, 2010

Andrographolide mitigates cardiac apoptosis to provide cardio-protection in high-fat-diet-induced obesity.May 31, 2020

Andrographolide promotes hippocampal neurogenesis and spatial memory in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease.Jan 24, 2021

Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB.Dec 31, 2012

Andrographolide radiosensitizes human ovarian cancer SKOV3 xenografts due to an enhanced apoptosis and autophagy.Oct 31, 2015

Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease.Jan 09, 2016

Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice.Dec 17, 2014

Andrographolide relieved pathological pain generated by spared nerve injury model.Nov 30, 2018

Andrographolide sensitizes the cytotoxicity of human colorectal carcinoma cells toward cisplatin.Apr 30, 2014

Andrographolide sulfonate ameliorates chronic colitis.May 31, 2020

Andrographolide suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo.Jan 31, 2014

Andrographolide, a compound found within andrographis, has anti-tumor activity in chemically-induced liver damage.Jun 01, 2005

Anti-diabetic activity and metabolic changes induced by Andrographis paniculata plant extract.Aug 08, 2016

Antidepressant evaluation of Andrographis paniculata Nees extract and andrographolide.Aug 31, 2023

Antioxidant and gastroprotective activities of Andrographis paniculata in Sprague Dawley rats.Sep 30, 2011

Antioxidant, antinociceptive and anti-inflammatory properties of the aqueous and ethanolic leaf extracts of Andrographis paniculata in some laboratory animals.Jun 30, 2015

Augmented rescue of macroglobulins by supplementation of anti-snake venom with methanolic extract of Andrographis paniculata.Oct 31, 2022

Beneficial effects of an Andrographis paniculata extract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats.Aug 31, 2016

Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage.Sep 30, 2014

Chemopreventive efficacy of Andrographis paniculata on azoxymethane-induced aberrant colon crypt foci in vivo.Dec 31, 2013

Compounds found within Andrographis have potent anti-influenza activity against H1N1 and Avian Flu. Jan 01, 2009

Curcumin and andrographis exhibit anti-tumor effects in colorectal cancer. Mar 01, 2023

Effect of Andrographis paniculata leaves extract on neurobehavioral and biochemical indices in scopolamine-induced amnesic rats.Dec 31, 2020

Effect of andrographolide on cysteamine-induced duodenal ulcer.Aug 31, 2011

Effect of two andrographolide derivatives on cellular and rodent models of non-alcoholic fatty liver disease.Oct 31, 2017

Hepatoprotective activity of Andrographis paniculata and Swertia chirayita.Nov 30, 2011

Andrographis

View the Evidence:
186 Abstracts with Andrographis Research