Andrographis

Name	AC	CK
Influenza	2	11
Cold and Flu	1	10
Common Cold	1	10
Familial Mediterranean Fever	1	10
Osteoarthritis: Knee	1	10
Respiratory Tract Infections	1	10
Rheumatoid Arthritis	1	10
Sinusitis	1	10
Upper Respiratory Infections	1	10
Liver Cancer	4	5
Cancer Metastasis	3	3
Cancers: All	3	3
Lymphoma	2	3
Avian Influenza	1	2
Chemically-Induced Liver Damage	1	2
Colon Cancer	2	2
Colorectal Cancer	2	2
Diabetic Nephropathy	1	2
Esophageal Cancer	1	2
H1N1 Infection	1	2
Immune Disorders: Low Immune Function	1	2
Influenza A	1	2
Kidney Diseases	1	2
Lymph Node Cancer	1	2
Malaria	1	2
Nephropathy: Diabetic	1	2
Pesticide Toxicity	1	2
Streptococcus Infections	1	2
Allergies	1	1
Cancer Stem Cells	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Diabetes Mellitus: Type 1	1	1
Epstein-Barr Virus Infections	1	1
Follicular Lymphoma	1	1
Gastric Cancer	1	1
H5N1 Infection	1	1
Inflammation	1	1
Lipopolysaccharide-Induced Toxicity	1	1
Lung Cancer	1	1
Multiple Myeloma	1	1
Multiple Sclerosis	1	1
Non-Hodgkin's lymphoma: B Cell	1	1
Promyelocytic leukemia	1	1
Prostate Cancer	1	1
Protozoan Infections	1	1
Rectal Cancer	1	1
Skin Cancer: Squamous Cell	1	1

Name	AC	CK
Analgesics	2	12
Immunomodulatory	4	6
Anti-metastatic	4	5
Apoptotic	5	5
Antineoplastic Agents	4	4
Antioxidants	2	4
Antiproliferative	2	3
Anti-Bacterial Agents	1	2
Anti-Inflammatory Agents	2	2
Anti-edemic	1	2
Anticarcinogenic Agents	1	2
Hepatoprotective	1	2
Renoprotective	1	2
Viral Hemagglutinin Inhibitor	1	2
Anti-Angiogenic	1	1
Antiprotozoal Agents	1	1
Antiviral Agents	1	1
Cell cycle arrest	1	1
Chemosensitizer	1	1
Epidermal growth factor receptor (EGFR) inhibitor	1	1
Insulin-releasing	1	1
Interleukin-6 Downregulation	1	1
Leukotriene Antagonists	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
NF-kappaB Inhibitor	1	1
Prostaglandin Antagonists	1	1
Thromboxane (TXB) Inhibitors	1	1
Tumor Necrosis Factor (TNF) Alpha Enhancer	1	1
Tumor Necrosis Factor (TNF) Alpha Inhibitor	1	1
Tumor Suppressor Protein p53 Upregulation	1	1

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A. paniculata significantly reduces fatigue in patients with relapsing-remitting multiple sclerosis receiving interferon beta.May 22, 2016

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Pubmed Data : BMC Neurol. 2016 May 23 ;16:77. Epub 2016 May 23. PMID: 27215274

Article Published Date : May 22, 2016

Study Type : Human Study

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Substances : Andrographis

Diseases : Fatigue, Multiple Sclerosis: Relapsing-Remitting

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Phytotherapy, Plant Extracts

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Andrographis extract was found to be effective and safe in reducing pain in individuals suffering from mild to moderate knee osteoarthritis.Apr 09, 2019

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Pubmed Data : Phytother Res. 2019 Apr 10. Epub 2019 Apr 10. PMID: 30968986

Immunomodulatory effects of Andrographis paniculata extract in healthy adults.Jun 30, 2021

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Pubmed Data : J Ayurveda Integr Med. 2021 Jul-Sep;12(3):529-534. Epub 2021 Aug 8. PMID: 34376353

Article Published Date : Jun 30, 2021

Study Type : Human Study

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Substances : Andrographis

Pharmacological Actions : Immunomodulatory

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Supplementation with a fixed combination of magnesium, vitamin B2, feverfew, Andrographis Paniculata and coenzyme Q10 for episodic migraine prophylaxis. Dec 26, 2020

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Pubmed Data : J Ethnopharmacol. 2016 Nov 4 ;192:170-177. Epub 2016 Jul 9. PMID: 27401291

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Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:8848797. Epub 2021 Mar 8. PMID: 33747115

Article Published Date : Dec 31, 2020

Study Type : Animal Study

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Substances : Andrographis

Diseases : Chronic Pain, Fever

Pharmacological Actions : Analgesics, Anti-pyretic

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Andrographis paniculata ameliorates carbon tetrachloride (CCl(4))-dependent hepatic damage and toxicity.Dec 31, 2010

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Pubmed Data : Biochim Biophys Acta. 2015 Apr ;1850(4):824-31. Epub 2015 Jan 29. PMID: 25641276

Article Published Date : Mar 31, 2015

Study Type : Animal Study

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Substances : Andrographis

Diseases : Diabetic Retinopathy

Pharmacological Actions : Anti-Angiogenic, Anti-Inflammatory Agents, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors

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Andrographolide ameliorates rheumatoid arthritis.Oct 10, 2019

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Pubmed Data : Int J Mol Sci. 2019 Oct 11 ;20(20). Epub 2019 Oct 11. PMID: 31614480

Article Published Date : Oct 10, 2019

Study Type : Animal Study

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Substances : Andrographis, Andrographolide

Diseases : Lipopolysaccharide-Induced Toxicity, Rheumatoid Arthritis

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents

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Andrographolide benefits rheumatoid arthritis via inhibiting MAPK pathways. Sep 30, 2017

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Pubmed Data : Inflammation. 2017 Oct ;40(5):1599-1605. PMID: 28584977

Article Published Date : Sep 30, 2017

Study Type : Animal Study

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Substances : Andrographis

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Andrographolide inhibits inflammatory responses in LPS-stimulated macrophages and murine acute colitis.Jan 11, 2019

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Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage.Sep 30, 2014

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Pubmed Data : Toxicol Appl Pharmacol. 2014 Oct 1 ;280(1):1-9. Epub 2014 Aug 7. PMID: 25110055

Article Published Date : Sep 30, 2014

Study Type : Animal Study

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Substances : Andrographis

Diseases : Chemically-Induced Liver Damage, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

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Chemopreventive efficacy of Andrographis paniculata on azoxymethane-induced aberrant colon crypt foci in vivo.Dec 31, 2013

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Pubmed Data : Biomed Pharmacother. 2017 Nov ;95:402-411. Epub 2017 Sep 12. PMID: 28863380

Article Published Date : Oct 31, 2017

Study Type : Animal Study, In Vitro Study

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Substances : Andrographis, Andrographolide

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

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Hepatoprotective activity of Andrographis paniculata and Swertia chirayita.Nov 30, 2011

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Pubmed Data : Food Chem Toxicol. 2011 Dec ;49(12):3367-73. Epub 2011 Sep 29. PMID: 21983487

Article Published Date : Nov 30, 2011

Study Type : Animal Study

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Pubmed Data : J Exp Ther Oncol. 2003 May-Jun;3(3):147-58. PMID: 14641821

Article Published Date : May 01, 2003

Study Type : In Vitro Study

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Substances : Andrographis

Diseases : Cancers: All

Pharmacological Actions : Cell cycle arrest, Immunomodulatory, Tumor Necrosis Factor (TNF) Alpha Enhancer

Additional Keywords : Plant Extracts

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Andrographis contains a compound which enhances chemosensitivity of cancer cells to doxorubicin.May 01, 2010

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Pubmed Data : Biochem Pharmacol. 2010 May 1;79(9):1242-50. Epub 2009 Dec 21. PMID: 20026083

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Pubmed Data : Evid Based Complement Alternat Med. 2009 Sep 14. Epub 2009 Sep 14. PMID: 19752167

Article Published Date : Sep 14, 2009

Study Type : Review

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Substances : Andrographis

Diseases : Cancers: All

Pharmacological Actions : Anti-Angiogenic, Immunomodulatory

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Andrographis may provide therapeutic activity in the treatment of Multiple Sclerosis. Jan 01, 2005

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Pubmed Data : J Pharmacol Exp Ther. 2005 Jan;312(1):366-72. Epub 2004 Aug 26 PMID: 15331658

Article Published Date : Jan 01, 2005

Study Type : In Vitro Study

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Substances : Andrographis

Diseases : Multiple Sclerosis

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Pubmed Data : Planta Med. 2014 May ;80(7):533-43. Epub 2014 Apr 29. PMID: 24782229

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Pubmed Data : Biochem Biophys Res Commun. 2020 Dec 10 ;533(3):467-473. Epub 2020 Aug 25. PMID: 32977949

Article Published Date : Dec 09, 2020

Study Type : In Vitro Study

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Substances : Andrographis

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

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Andrographolide as a potential inhibitor of SARS-CoV-2 main protease.Dec 31, 2020

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Pubmed Data : Proc Natl Acad Sci U S A. 2013 Jun 18 ;110(25):10201-6. Epub 2013 Jun 4. PMID: 23737504

Article Published Date : Jun 17, 2013

Study Type : In Vitro Study

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Substances : Andrographis

Diseases : Cancers: All

Pharmacological Actions : Anti-Inflammatory Agents

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Andrographolide effectively inhibits Epstein-barr virus.Nov 01, 2008

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Pubmed Data : Anticancer Drugs. 2019 08 ;30(7):e0774. PMID: 31306153

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

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Substances : Andrographis

Diseases : Cancers: Drug Resistant, Laryngeal Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Antineoplastic Agents, Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Drug Synergy

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Anti-SARS-CoV-2 activity of Andrographis paniculata extract.Jan 22, 2021

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Pubmed Data : Anticancer Agents Med Chem. 2019 ;19(14):1728-1736. PMID: 31284872

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

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Substances : Andrographis

Diseases : Osteosarcoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Cell cycle arrest

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Effect of Andrographis paniculata polysaccharide on human retinoblastoma Y79 cell proliferation and apoptosis.Dec 31, 2020

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Pubmed Data : Int J Ophthalmol. 2021 ;14(4):497-503. Epub 2021 Apr 18. PMID: 33875938

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

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Substances : Andrographis

Diseases : Retinoblastoma

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Polysaccharides

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Evaluation of anti-bacterial and anti-oxidant potential of andrographolide and echiodinin.Jul 31, 2013

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Pubmed Data : Pharm Biol. 2016 Nov ;54(11):2629-2635. Epub 2016 May 9. PMID: 27159496

Article Published Date : Oct 31, 2016

Study Type : In Vitro Study

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Substances : Andrographis

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

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The adjuvant value of Andrographis paniculata in metastatic esophageal cancer treatment - from preclinical perspectives.Jan 11, 2017

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Pubmed Data : Pharm Biol. 2012 Jul ;50(7):850-6. Epub 2012 May 16. PMID: 22587518

Article Published Date : Jun 30, 2012

Study Type : In Vitro Study

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Substances : Andrographis

Diseases : Aspergillosis, Candida Infection

Pharmacological Actions : Antifungal Agents

Additional Keywords : Plant Extracts

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This study illustrates the antiviral property of these Asian medicinal plants against the highly pathogenic avian H5N1 influenza virus.Aug 31, 2017

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Pubmed Data : Asian Pac J Trop Med. 2017 Sep ;10(9):871-876. Epub 2017 Sep 14. PMID: 29080615

Article Published Date : Aug 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Andrographis, Guava, Gynostemma, Kaempferia parviflora, Turmeric

Diseases : H5N1 Infection, Influenza

Pharmacological Actions : Antiviral Agents

Additional Keywords : Plant Extracts

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View the Evidence: 142 Abstracts with Andrographis Research

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A. paniculata significantly reduces fatigue in patients with relapsing-remitting multiple sclerosis receiving interferon beta.May 22, 2016

Andrographis extract was found to be effective and safe in reducing pain in individuals suffering from mild to moderate knee osteoarthritis.Apr 09, 2019

Andrographis has a positive effect in the treatment of acute upper respiratory tract infections and also relieves the inflammatory symptoms of sinusitis.Oct 01, 2002

Andrographis has therapeutic activity against upper respiratory tract infections.Mar 01, 2010

Andrographis reduces subjective and objective symptoms of rheumatoid arthritis. Aug 01, 2009

Andrographis, Eleutherococcus (Siberian Ginseng), Schisandra and Glycyrrhiza (Licorice) is safe and efficacious in the management of Familial Mediterranean Fever.Aug 01, 2008

Effect of Andrographis paniculata extract on triglyceride levels of the patients with hypertriglyceridemia.Jun 30, 2015

Immunomodulatory effects of Andrographis paniculata extract in healthy adults.Jun 30, 2021

Supplementation with a fixed combination of magnesium, vitamin B2, feverfew, Andrographis Paniculata and coenzyme Q10 for episodic migraine prophylaxis. Dec 26, 2020

A compound within Andrographis prevent diabetic nephropathy in an animal model. Aug 30, 2010

A standardised Andrographis paniculata Burm. Nees aqueous extract prevents Lipopolysaccharide-induced cognitive deficits.Feb 28, 2019

A. paniculata extract can be used for prevention and treatment of cardiovascular disease in obese patients.Nov 03, 2016

A. paniculata extracts significantly enhanced rate of wound healing.Dec 31, 2011

Activities of Andrographis paniculata tablet on Cox-2 and prostaglandin expression of placental of Plasmodium berghei infection.Dec 31, 2020

Analgesic and antipyretic activities of ethyl acetate fraction tablet of Andrographis paniculata.Dec 31, 2020

Andrographis and Hedyotis corymbosa in combination with curcumin have anti-malaria action.Feb 01, 2004

Andrographis does not appear to have any adverse effects on reproduction and fertility in male rats.Jul 01, 2009

Andrographis has a prophylactic effect against Streptococcus agalactiae infection in Nile tilapia.May 01, 2009

Andrographis has antioxidant, antioedema and analgesic activities.Jul 01, 2009

Andrographis has immunomodulatory activity. Jun 01, 2009

Andrographis may be more effective an anticancer agent than Doxorubicin in lymphoma. Dec 01, 2008

Andrographis paniculata ameliorates carbon tetrachloride (CCl(4))-dependent hepatic damage and toxicity.Dec 31, 2010

Andrographis paniculata extract prevents development of murine colitis.Dec 31, 2012

Andrographis paniculata extract protect against isoproterenol-induced myocardial injury.Feb 29, 2012

Andrographis paniculata improves insulin resistance in high-fat diet-induced obesity.Dec 31, 2019

Andrographis paniculata leaf extract prevents thioacetamide-induced liver cirrhosis in rats.Dec 31, 2013

Andrographis Paniculata shows anti-nociceptive effects in an animal model of sensory hypersensitivity associated with migraine.Dec 31, 2015

Andrographis paniculata was shown to possess anti-tumor, anti-metastatic and immunomodulatory activities in esophageal cancer cell.Mar 11, 2019

Andrographis paniculate could be used to improve PM2.5-induced lung injury by modulating the NF-κB pathway.Jul 12, 2021

Andrographolide ameliorates atherosclerosis by suppressing pro-inflammation and ROS generation-mediated foam cell formation.Sep 30, 2018

Andrographolide ameliorates d-galactosamine/lipopolysaccharide-induced acute liver injury by activating Nrf2 signaling pathway.Jun 19, 2017

Andrographolide ameliorates diabetic retinopathy by inhibiting retinal angiogenesis and inflammation.Mar 31, 2015

Andrographolide ameliorates rheumatoid arthritis.Oct 10, 2019

Andrographolide benefits rheumatoid arthritis via inhibiting MAPK pathways. Sep 30, 2017

Andrographolide inhibits inflammatory responses in LPS-stimulated macrophages and murine acute colitis.Jan 11, 2019

Andrographolide inhibits ovariectomy-induced bone loss.Nov 16, 2015

Andrographolide inhibits tumor angiogenesis via blocking VEGFA/VEGFR2-MAPKs signaling cascade.Jul 24, 2014

Andrographolide may have therapeutic value in the treatment of stroke.Sep 30, 2010

Andrographolide mitigates cardiac apoptosis to provide cardio-protection in high-fat-diet-induced obesity.May 31, 2020

Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB.Dec 31, 2012

Andrographolide radiosensitizes human ovarian cancer SKOV3 xenografts due to an enhanced apoptosis and autophagy.Oct 31, 2015

Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease.Jan 09, 2016

Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice.Dec 17, 2014

Andrographolide relieved pathological pain generated by spared nerve injury model.Nov 30, 2018

Andrographolide sensitizes the cytotoxicity of human colorectal carcinoma cells toward cisplatin.Apr 30, 2014

Andrographolide suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo.Jan 31, 2014

Andrographolide, a compound found within andrographis, has anti-tumor activity in chemically-induced liver damage.Jun 01, 2005

Anti-diabetic activity and metabolic changes induced by Andrographis paniculata plant extract.Aug 08, 2016

Antioxidant and gastroprotective activities of Andrographis paniculata in Sprague Dawley rats.Sep 30, 2011

Antioxidant, antinociceptive and anti-inflammatory properties of the aqueous and ethanolic leaf extracts of Andrographis paniculata in some laboratory animals.Jun 30, 2015

Beneficial effects of an Andrographis paniculata extract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats.Aug 31, 2016

Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage.Sep 30, 2014

Chemopreventive efficacy of Andrographis paniculata on azoxymethane-induced aberrant colon crypt foci in vivo.Dec 31, 2013

Compounds found within Andrographis have potent anti-influenza activity against H1N1 and Avian Flu. Jan 01, 2009

Effect of Andrographis paniculata leaves extract on neurobehavioral and biochemical indices in scopolamine-induced amnesic rats.Dec 31, 2020

Effect of andrographolide on cysteamine-induced duodenal ulcer.Aug 31, 2011

Effect of two andrographolide derivatives on cellular and rodent models of non-alcoholic fatty liver disease.Oct 31, 2017

Hepatoprotective activity of Andrographis paniculata and Swertia chirayita.Nov 30, 2011

Oral bioavailability enhancement and anti-fatigue assessment of the andrographolide loaded solid dispersion.Apr 03, 2020

Polyphenolic-rich extracts of Andrographis paniculata mitigate hyperglycemia.Nov 30, 2020

Protective effect of hydroalcoholic extract of Andrographis paniculata on ischaemia-reperfusion induced myocardial injury in rats.Feb 29, 2012

Synergetic effect of Andrographis paniculata polysaccharide on diabetic nephropathy with andrographolide.Nov 30, 2012

The anti-inflammatory effect of Andrographis paniculata on pelvic inflammatory disease.Nov 24, 2016

The ethanol leaf extract of Andrographis paniculata blunts acute renal failure in cisplatin-induced injury.Nov 29, 2018

The present study established that bioactive andrographolide served as a potential useful for dengue vector management.Oct 31, 2016

Vasorelaxant effect of diterpenoid lactones from Andrographis paniculata chloroform extract on rat aortic rings.Jun 30, 2010

"The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma."Jun 01, 2011

A novel microwave-assisted extraction for the isolation of andrographolide from Andrographis paniculata and its in vitro antioxidant activity.Sep 30, 2010

A polysaccharide from Andrographis paniculata induces mitochondrial-mediated apoptosis in human hepatoma cell line.Jun 30, 2015

A review for the neuroprotective effects of andrographolide in the central nervous system.Aug 31, 2019

Activity of phytochemical constituents of Curcuma longa and Andrographis paniculata against coronavirus COVID-19.Dec 31, 2019

An in vitro study of anti-inflammatory activity of standardised Andrographis paniculata extracts and pure andrographolide.Feb 06, 2015

Andrographis

View the Evidence:
142 Abstracts with Andrographis Research