Apigenin

Name	AC	CK
Inflammation	24	65
Cancers: All	29	49
Colorectal Cancer	11	39
Lipopolysaccharide-Induced Toxicity	16	29
Lung Injury: Acute	2	23
Prostate Cancer	14	23
Breast Cancer	18	22
Oxidative Stress	13	22
Rectal Cancer	1	20
Alzheimer's Disease	12	16
Pancreatic Cancer	10	16
Brain Inflammation	8	15
Melanoma	7	15
Obesity	7	11
Arsenic Poisoning	1	10
Breast Cancer: Triple Negative	9	10
Depression	5	10
Liver Cancer	9	10
Neurodegenerative Diseases	7	10
Renal Fibrosis	1	10
Cancers: Drug Resistant	7	9
High Fat Diet	5	9
Atherosclerosis	5	8
Colon Cancer	6	8
Liver Damage: Drug-Induced	4	8
Pesticide-Induced Toxicity: Organophosphates	3	8
Bladder Cancer	3	7
Cervical Cancer	6	7
Insulin Resistance	4	7
Kidney Damage: Chemically-Induced	3	7
Acetaminophen (Tylenol) Toxicity	3	6
Asthma	3	6
Cancer Metastasis	5	6
Cardiovascular Diseases	5	6
Chemotherapy-Induced Toxicity: Doxorubicin	4	6
DNA damage	2	6
Hyperuricemia	3	6
Lipid Peroxidation	2	6
Osteosarcoma	2	6
Ovarian Cancer	6	6
Parkinson's Disease	4	6
Ultraviolet Radiation Induced Damage	4	6
Atopic Dermatitis	3	5
Autoimmune Diseases	3	5
Bladder Cancer: Prevention	1	5
Diabetes Mellitus: Type 2	4	5
Diabetic Nephropathy	4	5
Lung Cancer	5	5
Multiple Sclerosis	1	5
Nonalcoholic fatty liver disease (NAFLD)	3	5
Pancreatitis	3	5
Pneumococcal Infections	1	5
Prostate Cancer Stem Cells	1	5
Rhinosinusitis	1	5
Streptococcus pneumoniae infection	1	5
Vitiligo	1	5
Allergic Rhinitis	2	4
Cerebral Ischemia	2	4
Chemically-Induced Liver Damage	3	4
Chemotherapy and Radiation Toxicity	2	4
Chemotherapy-Induced Toxicity: Cisplatin	3	4
Diabetic Complications	2	4
Drug Toxicity: Methotrexate	2	4
Endothelial Dysfunction	4	4
High Fructose Diet	2	4
Ischemia	2	4
Leishmaniasis	3	4
Liver Damage	3	4
Muscle Atrophy	2	4
Osteoarthritis	2	4
Radiation	2	4
Radiotherapy	2	4
Ulcerative Colitis	2	4
Wound Healing	3	4
Aging	2	3
Brain Ischemia	2	3
Carcinoma: Non-Small-Cell Lung	3	3
Chronic Kidney Disease (CKD)	1	3
Diabetes Mellitus: Type 1	2	3
Esophageal Cancer	3	3
Glioblastoma	3	3
Hypertension	2	3
Hypoxia	2	3
Intestinal Ischemia	1	3
Metabolic Syndrome X	2	3
Mitochondrial Dysfunction	2	3
Myocardial Ischemia	2	3
Myocarditis: Autoimmune	2	3
Oral Cancer	2	3
Pesticide Toxicity	2	3
Psoriasis	1	3
Sepsis	2	3
Skin Cancer	2	3
Stroke: Attenuation/Recovery	2	3
Thyroid Cancer	3	3
Aging Skin	1	2
Allodynia	1	2
Aluminum Toxicity	1	2
Animal Diseases: Infectious	1	2
Arthritis	1	2
Bisphenol Toxicity	1	2
Breast Cancer: Metastatic	2	2
Cardiac Hypertrophy	1	2
Cardiomyopathy	1	2
Chemical Exposure: Acrylonitrile	1	2
Chemotherapy-Induced Toxicity: Adriamycin	1	2
Chemotherapy-Induced Toxicity: Peripheral Neuropathy	1	2
Chikungunya Virus	2	2
Cognitive Decline/Dysfunction	1	2
Coronavirus Infection	2	2
Dysbiosis	1	2
Dyslipidemias	1	2
Encephalomyelitis	1	2
Enterovirus 71	1	2
Escherichia coli Infections	2	2
Excitotoxicity	1	2
Gastric Cancer	2	2
Gastric Spasm	1	2
Glioma	2	2
Gout	1	2
Hepatic Steatosis	1	2
Herbicide Toxicity	1	2
High Cholesterol	1	2
Hydrogen Peroxide Induced Toxicity	2	2
Hyperalgesia	1	2
Hypercholesterolemia	1	2
Hyperlipidemia	1	2
Immune Dysregulation: TH1/TH2 imbalance	1	2
Kidney Cancer	1	2
Kidney Damage	1	2
Kidney Damage: Drug-Induced	1	2
Kidney Stones	1	2
Laryngeal Cancer	1	2
Lead Poisoning	1	2
Liver Failure: Acute	1	2
Lung Damage	1	2
Lupus Erythematosus: Systemic	1	2
Malaria	1	2
Mesothelioma	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Multiple Sclerosis: Relapsing-Remitting	1	2
Myocardial Fibrosis	1	2
Nephropathy	1	2
Neuroblastoma	2	2
Neurologic Disorders	1	2
Osteoporosis: Age-Related	1	2
Pancreatitis: Chronic	1	2
Polycystic Ovary Syndrome	1	2
Pulmonary Hypertension	1	2
Rheumatoid Arthritis	2	2
Skin Diseases	1	2
Steptococcus Mutans Infections	2	2
Subarachnoid hemorrhage	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Tumors	2	2
Urolithiasis	1	2
Uveitis	1	2
Xerostomia	1	2
Acute T cell Leukemias	1	1
Acute lymphoblastic leukemia (ALL)	1	1
Alopecia: Androgenic	1	1
Aortic Aneurysm	1	1
Benzene Toxicity	1	1
Brain: Microglial Activation	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Breast Cancer: estrogen receptor alpha-positive	1	1
Cancers: Multi-Drug Resistant	1	1
Chemotherapy-Induced Kidney Damage	1	1
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	1
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	1
Choriocarcinoma	1	1
Chronic Obstructive Pulmonary Disease	1	1
Clotting	1	1
Colitis	1	1
Coronavirus Disease (Covid-19)	1	1
Dengue	1	1
Diabetes: Cataract	1	1
Diabetic Retinopathy	1	1
Endometriosis	1	1
Endometritis	1	1
Endothelial Damage	1	1
Fibrosis	1	1
H1N1 Infection	1	1
Hair Loss	1	1
Hepatitis A	1	1
Hepatitis B	1	1
Hepatitis C	1	1
Herpes Simplex Virus Type 1	1	1
Human Papillomavirus (HPV)	1	1
Hyperglycemia	1	1
Hyperinsulinism	1	1
Inflammatory Bowel Diseases	1	1
Influenza	1	1
Influenza A	1	1
Intervertebral Disk Displacement	1	1
Irritable Bowel Syndrome	1	1
Klebsiella Infections	1	1
Leukemia	1	1
Lipotoxicity	1	1
Lymphoma	1	1
Myelofibrosis	1	1
Pseudomonas aeruginosa	1	1
Rhabdoid Tumor	1	1
Rotavirus Infections	1	1
Scars	1	1
Sleep Disorders	1	1
Smoking	1	1
Staphylococcus aureus infection	1	1
Stroke: Ischemic	1	1
Thrombosis	1	1
Tongue Cancer	1	1
Toxoplasma gondii Infection	1	1
Weight Problems	1	1

Name	AC	CK
Anti-Inflammatory Agents	92	173
Antioxidants	58	119
Antiproliferative	76	108
Apoptotic	65	88
Chemopreventive	18	69
Neuroprotective Agents	33	55
Immunomodulatory	22	53
Anti-Apoptotic	24	46
NF-kappaB Inhibitor	22	46
Tumor Necrosis Factor (TNF) Alpha Inhibitor	28	44
Hepatoprotective	18	33
Renoprotective	18	33
Anti-metastatic	21	32
Interleukin-6 Downregulation	20	31
Cell cycle arrest	16	29
Chemotherapeutic	17	27
Interleukin-1 beta downregulation	16	27
Nrf2 activation	12	26
Cardioprotective	14	19
Chemoprotective Agents	12	18
Anti-Fibrotic	6	17
Chemosensitizer	15	16
MicroRNA modulator	11	14
Anticarcinogenic Agents	6	12
Radioprotective	6	11
Tumor Suppressor Protein p53 Upregulation	5	11
Antidepressive Agents	5	10
Antineoplastic Agents	8	10
Antiviral Agents	8	10
Detoxifier	1	10
Hypoglycemic Agents	7	10
Anti-Bacterial Agents	5	9
Enzyme Inhibitors	6	9
Bcl-2 protein down-regulation	4	8
Gastrointestinal Agents	5	8
Heme oxygenase-1 up-regulation	5	8
Interleukin-10 upregulation	4	7
Vascular Endothelial Growth Factor Inhibitors	6	7
Cyclooxygenase 2 Inhibitors	4	6
Gastroprotective	3	6
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	4	6
Interleukin-18 down-regulation	3	6
Matrix metalloproteinase-2 (MMP-2) inhibitor	4	6
P21 Activation	2	6
STAT3 Inhibitor	4	6
Wnt/β-catenin pathway down-regulation	2	6
Anti Inflammatory	1	5
Autophagy Up-regulation	3	5
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor	1	5
Immunomodulatory: Th17 downregulation	1	5
Malondialdehyde Down-regulation	3	5
Matrix metalloproteinase-9 (MMP-9) inhibitor	4	5
Pancreato Protective Agents	4	5
Angiogenesis Inhibitors	4	4
Brain-derived neurotrophic factor modulator	2	4
Chondroprotective	2	4
Interferon Gamma Reducer	2	4
Interleukin-2 Downregulation	2	4
Interleukin-4 downregulation	2	4
Leishmanicidal	3	4
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	2	4
Matrix metalloproteinase-1 (MMP-1) inhibitor	2	4
Matrix metalloproteinase-3 (MMP-3) inhibitor	2	4
Photoprotective	3	4
Superoxide Dismutase Up-regulation	2	4
Anti-Angiogenic	2	3
Antihypertensive Agents	2	3
Antiparasitic Agents	2	3
Hypolipidemic	2	3
Interleukin-23 Downregulation	1	3
Radiosensitizer	2	3
Wnt/β-catenin signaling pathway modulation	3	3
Anti-Asthmatic Agents	1	2
Anti-atherogenic	1	2
Anticholesteremic Agents	1	2
Antimalarials	1	2
Antispasmodic	1	2
Calcium Channel Blockers	1	2
Cyclooxygenase 1 Inhibitor	1	2
Cytoprotective	1	2
Excitatory Amino Acid Agonists	1	2
Hypoxia-inducible factor-1 (HIF-1) inhibitor	2	2
Interleukin-10 downregulation	1	2
Interleukin-4 upregulation	1	2
Interleukin-5 downregulation	1	2
Neuritogenic	1	2
Prophylactic Agents	1	2
Proteasome Inhibitors	2	2
SIRT1 Activator	1	2
Transforming growth factor beta (TGF-β) inhibitor	2	2
Transforming growth factor beta (TGF-β) upregulation	1	2
Uricosuric Agents	1	2
Vascular Endothelial Growth Factor A Inhibitor	1	2
Xanthine oxidase inhibitor	1	2
Acetylcholinesterase Inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Anti-thrombotic	1	1
Antimicrobial	1	1
Autophagy Inhibitors	1	1
Bcl-xL down-regulation	1	1
Cardiovascular Agents	1	1
Caspase-3 Activation	1	1
Caspase-8 activation	1	1
Cell Differentiation Inducer	1	1
Cytotoxic	1	1
Cytotoxicity	1	1
Dermatologic Agents	1	1
Estrogen Receptor Modulators	1	1
Genoprotective	1	1
Hepatocyte growth factor (HGF) inhibitor	1	1
Insulin Sensitizers	1	1
Insulin-Like Growth Factor Inhibition/Downregulation	1	1
Interferon Inducers	1	1
Interleukin-8 downregulation	1	1
Mitogen-activated protein kinase inhibitors	1	1
Paraptosis	1	1
Platelet Aggregation Inhibitors	1	1
Selective estrogen enzyme modulator (SEEM)	1	1
Topoisomerase I inhibitor	1	1
Vascular Endothelial Growth Factor Regulator	1	1
Vasodilator Agents	1	1
anti-inflammatory	1	1

Pharmacological Actions : Chemopreventive

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A combination of apigenin and EGCG prevent colorectal cancer recurrence. Apr 14, 2008

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Pubmed Data : World J Gastroenterol. 2008 Apr 14;14(14):2187-93. PMID: 18407592

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Pubmed Data : Immunol Invest. 2020 Feb 26:1-14. Epub 2020 Feb 26. PMID: 32100582

Article Published Date : Feb 25, 2020

Study Type : Human In Vitro

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Substances : Apigenin

Diseases : Multiple Sclerosis

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation

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The present study results indicated that human bladder cancer T-24 cells are highly sensitive to growth inhibition by apigenin.Dec 31, 2014

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Pubmed Data : Life Sci. 2023 Sep 1 ;328:121909. Epub 2023 Jul 4. PMID: 37414141

Article Published Date : Aug 31, 2023

Study Type : Animal Study, In Vitro Study

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Substances : Apigenin

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Psoriasis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-23 Downregulation, NF-kappaB Inhibitor

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Pubmed Data : Viruses. 2019 Jul 7 ;11(7). Epub 2019 Jul 7. PMID: 31284698

Article Published Date : Jul 06, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Apigenin, Flavonoids, Kaempferol, Luteolin

Diseases : Enterovirus 71

Pharmacological Actions : Antiviral Agents

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Apigenin accelerates wound healing in diabetic mice.Jan 22, 2024

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Pubmed Data : Mol Cell Biochem. 2024 Jan 23. Epub 2024 Jan 23. PMID: 38261238

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Pubmed Data : Invest Ophthalmol Vis Sci. 2023 May 1 ;64(5):21. PMID: 37219511

Article Published Date : Apr 30, 2023

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Lipopolysaccharide-Induced Toxicity, Uveitis

Pharmacological Actions : Anti-Inflammatory Agents

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Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

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Apigenin attenuates atherosclerosis and non-alcoholic fatty liver disease.May 16, 2023

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Pubmed Data : Chem Biol Interact. 2020 Jan 10 ;317:108942. Epub 2020 Jan 10. PMID: 31930969

Article Published Date : Jan 09, 2020

Study Type : Animal Study, In Vitro Study

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Substances : Apigenin

Diseases : Pulmonary Hypertension

Pharmacological Actions : Antihypertensive Agents, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor

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Apigenin can ameliorate HFD-induced comorbidities via metabolic and transcriptional modulations in the liver.Dec 31, 2015

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Pubmed Data : Avicenna J Phytomed. 2024 ;14(4):415-421. PMID: 38952770

Article Published Date : Dec 31, 2023

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substances Versus Drugs

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Apigenin could attenuate early brain injury after subarachnoid hemorrhage in rats by suppressing TLR4-mediated inflammation and protecting against BBB disruption.May 27, 2015

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Pubmed Data : Int Immunopharmacol. 2015 May 28 ;28(1):79-87. Epub 2015 May 28. PMID: 26028151

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Pubmed Data : Mol Med Rep. 2020 Dec ;22(6):4877-4889. Epub 2020 Oct 8. PMID: 33174048

Article Published Date : Nov 30, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Melanoma

Pharmacological Actions : Antiproliferative , Apoptotic

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Apigenin inhibited in vitro and in vivo malignant mesothelioma cells growth by targeting different signaling pathways.Dec 31, 2016

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Pubmed Data : Pharmacol Res. 2019 Dec 23 ;152:104586. Epub 2019 Dec 23. PMID: 31877350

Article Published Date : Dec 22, 2019

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Obesity

Pharmacological Actions : STAT3 Inhibitor

Additional Keywords : Anti-Obesity Agents

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Apigenin inhibits the progression of osteoarthritis.Mar 23, 2023

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Pubmed Data : Cancers (Basel). 2022 Apr 4 ;14(7). Epub 2022 Apr 4. PMID: 35406599

Article Published Date : Apr 03, 2022

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Cervical Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

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Apigenin may attenuate atherogenesis through up-regulating ABCA1-mediated cholesterol efflux and inhibiting inflammation.Jul 04, 2018

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Pubmed Data : Immunopharmacol Immunotoxicol. 2016 Jun ;38(3):228-237. PMID: 27144896

Article Published Date : May 31, 2016

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Sepsis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-10 upregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Apigenin may have a protective effect against Adriamycin induced cardiotoxicity.Dec 31, 2016

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Pubmed Data : Front Pharmacol. 2020 ;11:514. Epub 2020 Apr 24. PMID: 32425778

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Pubmed Data : Front Pharmacol. 2024 ;15:1362301. Epub 2024 Apr 30. PMID: 38746012

Article Published Date : Dec 31, 2023

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Stroke: Ischemic

Pharmacological Actions : Antioxidants, DNA Repair Up-regulation, Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation

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Pubmed Data : J Pharm Pharmacol. 2018 Sep ;70(9):1253-1261. Epub 2018 Jun 25. PMID: 29943490

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Pubmed Data : J Exp Clin Cancer Res. 2018 Oct 29 ;37(1):261. Epub 2018 Oct 29. PMID: 30373602

Pubmed Data : Mol Neurobiol. 2024 Jan 8. Epub 2024 Jan 8. PMID: 38191695

Article Published Date : Jan 07, 2024

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Pubmed Data : Environ Sci Pollut Res Int. 2022 Nov 5. Epub 2022 Nov 5. PMID: 36334201

Article Published Date : Nov 04, 2022

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

Problem Substances : Monosodium Glutamate (MSG)

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Naringenin and apigenin ameliorates corticosterone-induced depressive behaviors.Apr 30, 2023

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Pubmed Data : Biochem Pharmacol. 2015 Jun 17. Epub 2015 Jun 17. PMID: 26093063

Article Published Date : Jun 16, 2015

Study Type : Animal Study

Additional Links

Substances : Apigenin, Flavonoids, Kaempferol

Diseases : Cardiovascular Diseases, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator, NF-kappaB Inhibitor

Additional Keywords : Senescence-associated Secretory Phenotype

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Potential antioxidant activity of apigenin in the obviating stress-mediated depressive symptoms.Dec 18, 2022

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Pubmed Data : Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221084276. PMID: 35373622

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Pubmed Data : BMC Pharmacol Toxicol. 2019 May 3 ;20(1):22. Epub 2019 May 3. PMID: 31053173

Article Published Date : May 02, 2019

Study Type : In Vitro Study

Additional Links

Substances : Apigenin, Hesperidin

Diseases : Liver Cancer

Pharmacological Actions : Chemosensitizer, Chemotherapeutic

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

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Apigenin and hesperidin downregulate DNA repair genes in MCF-7 breast cancer cells and augment doxorubicin toxicity. Sep 25, 2020

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Pubmed Data : Molecules. 2020 Sep 26 ;25(19). Epub 2020 Sep 26. PMID: 32993087

Apigenin as an ideal therapeutic for ameliorating doxorubicin resistance in breast cancer. Jul 07, 2022

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Pubmed Data : Mol Biol Rep. 2022 Jul 8. Epub 2022 Jul 8. PMID: 35804214

Article Published Date : Jul 07, 2022

Study Type : In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Breast Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

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Apigenin as tumor suppressor in cancers: biotherapeutic activity, nanodelivery, and mechanisms with emphasis on pancreatic cancer.Dec 31, 2019

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Pubmed Data : Oncol Rep. 2009 Dec;22(6):1533-7. PMID: 19885610

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Pubmed Data : Anticancer Agents Med Chem. 2016 Apr 25. Epub 2016 Apr 25. PMID: 27109019

Article Published Date : Apr 24, 2016

Study Type : In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic, Chemotherapeutic

Additional Keywords : Selective Cytotoxicity

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Apigenin could be used to potentially increase the effects of cisplatin by targeting cancer stem cells subset in prostate cancer.Mar 31, 2017

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Pubmed Data : Biomed Pharmacother. 2017 Apr ;88:210-217. Epub 2017 Jan 17. PMID: 28107698

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Pubmed Data : Redox Biol. 2021 11 ;47:102144. Epub 2021 Sep 21. PMID: 34562873

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Pubmed Data : Phytother Res. 2019 Aug 30. Epub 2019 Aug 30. PMID: 31468624

Article Published Date : Aug 29, 2019

Study Type : In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Glioma

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interleukin-6 Downregulation

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Apigenin impedes cell cycle progression at G 2 phase in prostate cancer cells.Jun 06, 2022

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Pubmed Data : BMC Ophthalmol. 2023 Jul 6 ;23(1):302. Epub 2023 Jul 6. PMID: 37415101

Article Published Date : Jul 05, 2023

Study Type : In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Diabetic Retinopathy

Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative

Additional Keywords : MicroRNA-140

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Apigenin inhibits antiestrogen-resistant breast cancer cell growth. Nov 01, 2006

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Pubmed Data : J Pineal Res. 2006 Nov;41(4):358-62. PMID: 18645020

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Apigenin inhibits the histamine-induced proliferation of ovarian cancer cells.Dec 31, 2020

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Pubmed Data : J Cell Physiol. 2016 Mar 11. Epub 2016 Mar 11. PMID: 26970256

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Pubmed Data : Food Nutr Res. 2016 ;60:31288. Epub 2016 Jun 28. PMID: 27356910

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Cervical Cancer

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Gene Expression Regulation

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Apigenin pretreatment enhances growth and salinity tolerance of rice seedlings.Jun 29, 2018

Pubmed Data : World J Surg Oncol. 2023 Mar 14 ;21(1):95. Epub 2023 Mar 14. PMID: 36915121

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Pubmed Data : Oncol Lett. 2016 May ;11(5):3075-3080. Epub 2016 Mar 16. PMID: 27123066

Article Published Date : Apr 30, 2016

Study Type : In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Wnt/β-catenin pathway down-regulation

Additional Keywords : Dose Response

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Apigenin simulates hair growth in an in vitro model. Nov 01, 2009

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Pubmed Data : Br J Sports Med. 2009 Nov;43(11):840-4. Epub 2008 Apr 2. PMID: 19277688

Article Published Date : Nov 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Alopecia: Androgenic, Hair Loss

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Apigenin suppresses cancer invasion by inhibiting EMT by suppressing NF-κB-Snail signaling. May 16, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2024 Jun 1 ;29(11). Epub 2024 Jun 1. PMID: 38893482

Article Published Date : May 31, 2024

Study Type : In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

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Apigenin, chrysin, and luteolin may inhibit tumor cells via proteasome inhibitory activity. Feb 01, 2010

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Pubmed Data : Planta Med. 2010 Feb;76(2):128-32. Epub 2009 Aug 3. PMID: 19653143

Pubmed Data : Anticancer Agents Med Chem. 2022 May 16. Epub 2022 May 16. PMID: 35578854

Article Published Date : May 15, 2022

Study Type : Review

Additional Links

Substances : Apigenin, Eugenol, Ferulic acid, Quercetin

Diseases : Cancers: All

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

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Chrysin combined with apigenin can reduce HepG2 and MDA-MB-231 proliferation, cell motility and induce apoptosis.May 02, 2016

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Pubmed Data : J Agric Food Chem. 2016 May 3. Epub 2016 May 3. PMID: 27137679

Article Published Date : May 02, 2016

Study Type : In Vitro Study

Additional Links

Substances : Apigenin, Chrysin, Noni

Diseases : Breast Cancer, Breast Cancer: Triple Negative , Liver Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Natural Substance Synergy, Plant Extracts

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Clarifying the mechanism of apigenin against blood-brain barrier disruption in ischemic stroke using systems pharmacology.Mar 21, 2023

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Pubmed Data : Mol Divers. 2023 Mar 22. Epub 2023 Mar 22. PMID: 36949297

Article Published Date : Mar 21, 2023

Study Type : In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Stroke: Ischemic

Pharmacological Actions : Neuroprotective Agents

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Co-administration of apigenin with doxorubicin enhances anti-migration and antiproliferative effects.Dec 31, 2020

Pubmed Data : J Cardiovasc Pharmacol. 2019 Oct 7. Epub 2019 Oct 7. PMID: 31517778

Article Published Date : Oct 06, 2019

Study Type : In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Endothelial Dysfunction

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Differential effects of cisplatin combined with the flavonoid apigenin on HepG2, Hep3B, and Huh7 liver cancer cell lines.May 31, 2021

Click here to read the entire abstract

Pubmed Data : Mutat Res. 2021 Jun ;866:503352. Epub 2021 Mar 24. PMID: 33985696

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View the Evidence: 391 Abstracts with Apigenin Research

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Apigenin in cancer prevention and therapy.Jul 31, 2022

The effects of apigenin administration on the inhibition of inflammatory responses and oxidative stress in the lung injury models.Jun 03, 2022

High intake of flavonols may reduce the risk of colon cancer and high intake of flavones may reduce the risk of rectal cancer.Jul 22, 2018

A combination of apigenin and EGCG prevent colorectal cancer recurrence. Apr 14, 2008

Apigenin could be an attractive therapeutic potential for the treatment of renal fibrosis.Mar 20, 2020

Dietary flavonoids improve urinary arsenic elimination among Mexican women.Jun 30, 2018

Apigenin and Luteolin significantly activate the PI3K/Nrf2/ARE system, and this activation may be responsible for their anti-inflammatory effects.Apr 21, 2015

Apigenin could be a potent dietary anti-oxidant regimen against edifenphos-induced toxicity on human health.Apr 30, 2019

Apigenin could be a useful compound to prevent proliferation and migration of cancer cells as well as cancer stem cells.Aug 24, 2016

Apigenin could directly interact with pneumolysin to decrease the pathogenicity of S. pneumoniae.Sep 27, 2016

Apigenin highly upregulated the expression of cytokine genes and induced apoptosis in human pancreatic cancer cells.Nov 30, 2013

Apigenin is a novel therapeutic candidate for melanoma.Feb 13, 2017

Apigenin is a promising chemotherapeutic agent that may be used in the treatment of human osteosarcoma.Jul 31, 2015

Apigenin protects human melanocytes against oxidative damage by activation of the Nrf2 pathway.Jan 17, 2020

Apigenin reduces proteasome inhibition-induced neuronal apoptosis.Oct 31, 2016

Luteolin and apigenin derived glycosides from Alphonsea elliptica abrogate LPS-induced inflammatory responses in human plasma.Apr 19, 2021

Modulation of Th17 proliferation and IL-17A gene expression by acetylated form of apigenin in patients with multiple sclerosis.Feb 25, 2020

The present study results indicated that human bladder cancer T-24 cells are highly sensitive to growth inhibition by apigenin.Dec 31, 2014

These results suggests the possible use of apigenin as a chronic rhinosinusitis therapeutic agent which can suppress tissue remodelling in nasal mucosa.Dec 31, 2017

This demonstrates the broad neuroprotective action of apigenin against AD pathogenesis in a human disease model.Dec 31, 2015

Ameliorative effect of traditional polyherbal formulation on TNF-α, IL-1β and Caspase-3 expression in kidneys.Jul 10, 2023

Apigenin promotes apoptosis of 4T1 cells through PI3K/AKT/Nrf2 pathway and improves tumor immune microenvironment.Jan 31, 2024

Apigenin was found effective against psoriasis in both in-vitro and in-vivo models.Aug 31, 2023

Apigenin-7-glucoside-loaded nanoparticle alleviates intestinal ischemia-reperfusion.Jan 01, 2024

Neuroprotective effects of apigenin on retinal ganglion cells in ischemia/reperfusion.May 12, 2024

Neuroprotective effect of apigenin against cerebral ischemia/reperfusion injury.Aug 31, 2020

Anti-atopic dermatitis effects of hydrolyzed celery extract. Mar 22, 2020

Antioxidant apigenin relieves age-related muscle atrophy.Aug 27, 2020

Antiviral efficacy of flavonoids against enterovirus 71 infection.Jul 06, 2019

Apigenin accelerates wound healing in diabetic mice.Jan 22, 2024

Apigenin administration effectively ameliorated autoimmune myocarditis-induced cardiac hypertrophy and cardiac dysfunctionDec 10, 2015

Apigenin alleviates allodynia and hyperalgesia in a mouse model of chemotherapy-induced peripheral neuropathy.May 07, 2023

Apigenin alleviates autoimmune uveitis.Apr 30, 2023

Apigenin alleviates cancer drug Sorafenib induced multiple toxic effects in Swiss albino mice via anti-oxidative stress.Jul 14, 2022

Apigenin alleviates methotrexate-induced liver and kidney injury in mice.Apr 11, 2021

Apigenin ameliorated the obesity-induced skeletal muscle atrophy by attenuating mitochondrial dysfunction.Oct 01, 2017

Apigenin ameliorates genitourinary dysfunction in a type 1 diabetic rat model via Drp1 modulation.Mar 07, 2024

Apigenin ameliorates HFD-induced NAFLD through regulation of the XO/NLRP3 pathways.Jun 13, 2019

Apigenin ameliorates hypercholesterolemic-induced kidney injury.Jan 31, 2023

Apigenin ameliorates hyperuricemia and renal injury.Nov 20, 2022

Apigenin ameliorates hyperuricemic nephropathy.May 22, 2021

Apigenin and myricetin exhibited a protective and promising preventive strategy against cisplatin-induced nephrotoxicity.Nov 30, 2017

Apigenin and naringenin can ameliorate glucose and lipid metabolism, as well as endothelial dysfunction in T2D ratsJan 19, 2016

Apigenin and quercetin may have a therapeutic role in preventing and treating gastric spasm. Jul 03, 2009

Apigenin and resveratrol could prevent tissue damage induced by radiation effects.Oct 30, 2023

Apigenin attenuates acetaminophen-induced hepatotoxicity. Dec 31, 2019

Apigenin attenuates atherosclerosis and non-alcoholic fatty liver disease.May 16, 2023

Apigenin attenuates doxorubicin induced cardiotoxicity via reducing oxidative stress and apoptosis.Jul 03, 2019

Apigenin attenuates edifenphos-induced toxicity.Aug 31, 2019

Apigenin attenuates hippocampal microglial activation and restores cognitive function in methotrexate-treated rats.Jun 30, 2023

Apigenin attenuates inflammatory response in allergic rhinitis.Jan 31, 2023

Apigenin attenuates LPS-induced neurotoxicity and cognitive impairment.Nov 30, 2022

Apigenin attenuates pulmonary hypertension.Jan 09, 2020

Apigenin can ameliorate HFD-induced comorbidities via metabolic and transcriptional modulations in the liver.Dec 31, 2015

Apigenin can be used as a promising agent to reduce the renal adverse reaction of Imipenem in clinic.May 27, 2020

Apigenin can regulate the gene expression, secretion, and activity of MMP-3, by directly acting on articular chondrocytes.Feb 29, 2016

Apigenin can suppress serum inflammatory cytokines, similar to dexamethasone.Dec 31, 2023

Apigenin could attenuate early brain injury after subarachnoid hemorrhage in rats by suppressing TLR4-mediated inflammation and protecting against BBB disruption.May 27, 2015

Apigenin could be explored as a new dietary strategy to combat obesity and related insulin resistance.Oct 31, 2019

Apigenin could improve hypertensive cardiac hypertrophy and abnormal myocardial glucolipid metabolism in rats.Mar 17, 2016

Apigenin could inhibit the growth of cisplatin-resistant colon cancer cells in vitro and in vivo.Feb 28, 2019

Apigenin demonstrates growth inhibitory activity in cultured breast cells and xenografts, without toxicity. Aug 15, 2009

Apigenin enhances the anti-tumor effect of gemcitabine. Jan 18, 2008

Apigenin exhibits leishmanicidal effects against L. amazonensis-infected macrophages. Jan 31, 2016

Apigenin exposure induces DNA damage, G2/M phase cell cycle arrest, p53 accumulation and apoptosis in kidney cancer cells.Mar 20, 2017

Apigenin has a protective effect against ovariectomy-induced bone loss in rats.Jun 20, 2008

Apigenin has a protective role against lipid peroxidation and oxidative stress associated with the development of liver cancer in rats. Dec 01, 2009

Apigenin has good hepatoprotective effects and potential as a promising therapeutic agent for acute liver failure in clinical application.Jan 10, 2019

Apigenin increased the expression of Bcl-2 and reduced Fas/FasL expression in renal ischemia-reperfusion injury.Nov 30, 2017

Apigenin induces apoptosis by regulating Akt and MAPK pathways in human melanoma cell A375SM.Nov 30, 2020

Apigenin inhibited in vitro and in vivo malignant mesothelioma cells growth by targeting different signaling pathways.Dec 31, 2016

Apigenin inhibits growth of the Plasmodium berghei and disrupts some metabolic pathways in mice.Aug 31, 2018

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View the Evidence:
391 Abstracts with Apigenin Research