Apple Polyphenols

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63 Diseases Researched for Apple Polyphenols
NameACCKFocus
Hyperglycemia220Locked
Endothelial Dysfunction416Locked
Hair Loss312Locked
Athletic Performance110Locked
Hyperuricemia110Locked
Overweight 110Locked
Peripheral Arterial Disease110Locked
Prediabetes110Locked
Skin Diseases: Photo-Aging110Locked
Ultraviolet Radiation Induced Damage110Locked
Colorectal Cancer49Locked
Oxidative Stress47Locked
Insulin Resistance36Locked
Anti-gliadin Antibodies: Elevated15Locked
Cancers: All15Locked
Food Allergies: Wheat15Locked
Inflammatory Bowel Diseases35Locked
Aluminum Toxicity 24Locked
Atherosclerosis24Locked
Cholera24Locked
Hepatic Steatosis24Locked
Hypertension: Pulmonary24Locked
Obesity24Locked
Ulcerative Colitis24Locked
Breast Cancer33Locked
Breast Cancer: Triple Negative 33Locked
Cardiovascular Diseases23Locked
Colon Cancer33Locked
Diabetes Mellitus: Type 223Locked
Aging12Locked
Alcohol Toxicity 12Locked
Aspirin-Induced Toxicity 12Locked
Brain: Oxidative Stress12Locked
Chemically-Induced Liver Damage12Locked
Colitis12Locked
Colon Polyps12Locked
Colorectal Cancer: Prevention 12Locked
Drug-Induced Toxicity: Indomethacin12Locked
Dysbiosis12Locked
High Fat Diet12Locked
Hypoxia12Locked
Liver Damage: Drug-Induced12Locked
Mitochondrial Dysfunction 12Locked
Muscle Fatigue12Locked
Osteoarthritis12Locked
Vaccine-induced Toxicity 12Locked
Advanced Glycation End products (AGE)11Locked
Aging: Brain 11Locked
Allergic Rhinitis11Locked
Cardiovascular Disease: Prevention11Locked
Chemotherapy and Radiation Toxicity11Locked
Diabetic Complications11Locked
Escherichia coli Infections11Locked
Gastrointestinal Inflammation11Locked
Hypercholesterolemia11Locked
Listeria Infections11Locked
Liver Cancer11Locked
Neurodegenerative Diseases11Locked
Nonalcoholic fatty liver disease (NAFLD)11Locked
Oral Cancer11Locked
Periodontal Diseases11Locked
Squamous cell carcinoma11Locked
Staphylococcus aureus infection11Locked
55 Pharmacological Actions Researched for Apple Polyphenols
NameACCKFocus
Hypoglycemic Agents440Locked
Antioxidants1736Locked
Anti-Inflammatory Agents917Locked
Hepatoprotective815Locked
Antiproliferative 610Locked
Photoprotective110Locked
Uricosuric Agents110Locked
Anti-metastatic48Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor47Locked
Tumor Suppressor Protein p53 Upregulation37Locked
Anti-Allergic Agents26Locked
Chemopreventive56Locked
Angiogenesis Inhibitors15Locked
Apoptotic55Locked
Neuroprotective Agents35Locked
Vascular Endothelial Growth Factor Inhibitors15Locked
Anti-Apoptotic24Locked
Anti-atherogenic24Locked
Cyclooxygenase 2 Inhibitors24Locked
Gastroprotective24Locked
Cardioprotective23Locked
Cell cycle arrest33Locked
Enzyme Inhibitors23Locked
NF-kappaB Inhibitor23Locked
Antidiarrheals12Locked
Antihypertensive Agents12Locked
Antimicrobial12Locked
Autophagy Up-regulation22Locked
Catalase Up-Regulation12Locked
Chelating Agents12Locked
Chondroprotective12Locked
Gastrointestinal Agents12Locked
Insulin Sensitizers12Locked
Interferon Gamma Reducer12Locked
Malondialdehyde Down-regulation12Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor22Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor22Locked
MicroRNA modulator12Locked
Superoxide Dismutase Up-regulation12Locked
Vasodilator Agents12Locked
Acetylcholinesterase Inhibitor11Locked
Alpha-glucosidase inhibitor 11Locked
Anti-Bacterial Agents11Locked
Anti-Glycation Agents11Locked
Anticholesteremic Agents11Locked
Caspase-3 Activation11Locked
Chemoprotective Agents11Locked
Cyclin D1 Down-Regulation11Locked
Glutathione Upregulation 11Locked
Hypolipidemic11Locked
Interleukin-1 beta downregulation11Locked
Nrf2 activation11Locked
P21 Activation11Locked
Topoisomerase II Inhibitor11Locked
Wnt/β-catenin pathway down-regulation11Locked
Related Topics

Apple Polyphenols is a Sub of the following Topic

View the Evidence:
75 Abstracts with Apple Polyphenols Research

[+]

Apple or apple polyphenol consumption improves cardiovascular disease risk factors.Sep 23, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Rev Cardiovasc Med. 2021 Sep 24 ;22(3):835-843. PMID: 34565081
Article Published Date : Sep 23, 2021
Study Type : Meta Analysis, Review
Additional Links
Substances : Apple Polyphenols
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective
[+]

An acute dose of specific grape and apple polyphenols improves endurance performance.Aug 21, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Aug 22 ;9(8). Epub 2017 Aug 22. PMID: 28829368
Article Published Date : Aug 21, 2017
Study Type : Human Study
Additional Links
Substances : Apple Polyphenols, Grapes
Diseases : Athletic Performance
Therapeutic Actions : Exercise: Endurance
[+]

Annurca apple polyphenolic extract could be a promising natural and safe tool for treatment of symptoms related to peripheral arterial disease.Dec 02, 2018

Pubmed Data : Am J Cardiol. 2018 Dec 3. Epub 2018 Dec 3. PMID: 30573159
Article Published Date : Dec 02, 2018
Study Type : Human Study
Additional Links
Substances : Apple Polyphenols
Diseases : Peripheral Arterial Disease
[+]

Apple and blackcurrant polyphenol-rich drinks decrease postprandial glucose, insulin and incretin response to a high-carbohydrate meal in healthy men and women.Jul 26, 2017

Pubmed Data : J Nutr Biochem. 2017 Jul 27 ;49:53-62. Epub 2017 Jul 27. PMID: 28886437
Article Published Date : Jul 26, 2017
Study Type : Human Study
Additional Links
Substances : Apple Polyphenols, Black Currant
Pharmacological Actions : Hypoglycemic Agents
[+]

Apple polyphenol-rich drinks dose-dependently decrease early-phase postprandial glucose concentrations following a high-carbohydrate meal.Jul 29, 2020

Pubmed Data : J Nutr Biochem. 2020 Jul 30:108466. Epub 2020 Jul 30. PMID: 32739411
Article Published Date : Jul 29, 2020
Study Type : Human Study
Additional Links
Substances : Apple Polyphenols
Diseases : Hyperglycemia
Pharmacological Actions : Hypoglycemic Agents
[+]

Apple polyphenols extract has a positive effect on vascular oxidative stress and endothelium function.Jul 28, 2017

Pubmed Data : Mol Nutr Food Res. 2017 Jul 29. Epub 2017 Jul 29. PMID: 28755406
Article Published Date : Jul 28, 2017
Study Type : Human Study
Additional Links
Substances : Apple Polyphenols
Diseases : Endothelial Dysfunction, Hyperuricemia, Overweight
Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Uricosuric Agents
[+]

Apple procyanidin B2 on keratin biosynthesis in vitro, and highlights its effect as a nutraceutical on human hair growth and tropism.Sep 27, 2017

Pubmed Data : J Med Food. 2017 Sep 28. Epub 2017 Sep 28. PMID: 28956697
Article Published Date : Sep 27, 2017
Study Type : Human In Vitro, Human Study
Additional Links
Substances : Apple Polyphenols, Procyanidin B2
Diseases : Hair Loss
Additional Keywords : Hair Regeneration, Procyanidins
[+]

Chronic apple polyphenols administration significantly improved impaired glucose tolerance in high-normal and borderline subjects.May 01, 2017

Pubmed Data : Diabetes Res Clin Pract. 2017 May 2 ;129:43-51. Epub 2017 May 2. PMID: 28505543
Article Published Date : May 01, 2017
Study Type : Human Study
Additional Links
Substances : Apple Polyphenols
Diseases : Hyperglycemia, Prediabetes
Pharmacological Actions : Hypoglycemic Agents
[+]

Continuous administration of apple polyphenol for 12 weeks alleviated ultraviolet irradiation induced skin pigmentation.Apr 12, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Apr 13 ;12(4). Epub 2020 Apr 13. PMID: 32294883
Article Published Date : Apr 12, 2020
Study Type : Human Study
Additional Links
Substances : Apple Polyphenols
Diseases : Skin Diseases: Photo-Aging, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Photoprotective
[+]

Polyphenol interactions mitigate the immunogenicity and allergenicity of gliadins.Feb 12, 2017

Pubmed Data : J Agric Food Chem. 2017 Feb 13. Epub 2017 Feb 13. PMID: 28190352
Article Published Date : Feb 12, 2017
Study Type : Human In Vitro
Additional Links
Substances : Apple Polyphenols, Artichoke, Cranberry, Green Tea, Polyphenols
Diseases : Anti-gliadin Antibodies: Elevated, Food Allergies: Wheat
Pharmacological Actions : Anti-Allergic Agents
Additional Keywords : Plant Extracts
[+]

The apple polyphenol phloretin inhibits colorectal cancer cell growth.Sep 13, 2016

Pubmed Data : J Agric Food Chem. 2016 Sep 14 ;64(36):6826-37. Epub 2016 Sep 2. PMID: 27538679
Article Published Date : Sep 13, 2016
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Apple Polyphenols, Phloretin
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Tumor Suppressor Protein p53 Upregulation
[+]

VEGF is a key molecular target for specific polyphenols found in tea, apples and cocoa which potently inhibit VEGF signalling and angiogenesis at physiological concentrations.Feb 28, 2015

Pubmed Data : Mol Nutr Food Res. 2015 Mar ;59(3):401-12. Epub 2015 Jan 22. PMID: 25546248
Article Published Date : Feb 28, 2015
Study Type : Human In Vitro
Additional Links
Substances : Apple Polyphenols, EGCG (Epigallocatechin gallate), Polyphenols
Diseases : Cancers: All
Pharmacological Actions : Angiogenesis Inhibitors, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Diet
[+]

A mixture of phytochemicals naturally present in foods represents a plausible chemopreventive agent for colorectal cancer.May 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Prev Res (Phila). 2011 Jun ;4(6):907-15. Epub 2011 Mar 7. PMID: 21383028
Article Published Date : May 31, 2011
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols, Apples, Flavonoids
Diseases : Colon Polyps, Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Antioxidants, Chemopreventive
Additional Keywords : Dietary Concentrations
[+]

A quercetin, EGCG and apple polyphenol concentrate improved disorders of lipid metabolism and pro-oxidant-antioxidant homeostasis.Dec 31, 2016

Pubmed Data : Wiad Lek. 2017;70(2):200-204. PMID: 28511159
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols, Catechin , EGCG (Epigallocatechin gallate), Quercetin
Diseases : Insulin Resistance
Pharmacological Actions : Antioxidants
Additional Keywords : Natural Substance Synergy, Plant Extracts
[+]

Administered apple procyanidins ameliorate insulin resistance by improving hepatic insulin signalling through suppression of hepatic inflammation.Nov 22, 2016

Pubmed Data : J Agric Food Chem. 2016 Nov 23 ;64(46):8857-8865. Epub 2016 Nov 10. PMID: 27792335
Article Published Date : Nov 22, 2016
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Diabetes Mellitus: Type 2, Insulin Resistance
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
Additional Keywords : Procyanidins
[+]

Administration of apple procyanidins led to the regression of atherosclerosis.Jan 26, 2017

Pubmed Data : Atherosclerosis. 2017 Jan 27 ;258:56-64. Epub 2017 Jan 27. PMID: 28196336
Article Published Date : Jan 26, 2017
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Atherosclerosis
Pharmacological Actions : Anti-atherogenic
[+]

An apple polyphenol extract plays a role in the reduction of the toxic effects from aluminum chloride in rats.Jan 31, 2014

Pubmed Data : Can J Physiol Pharmacol. 2014 Feb ;92(2):109-16. Epub 2014 Jan 29. PMID: 24502633
Article Published Date : Jan 31, 2014
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Aluminum Toxicity , Oxidative Stress
Pharmacological Actions : Hepatoprotective
Problem Substances : Aluminum Chloride
[+]

Apple and especially apple peel may be excellent preventive agents against cardiovascular disorders.Nov 05, 2017

Pubmed Data : Clin Exp Hypertens. 2017 Nov 6:1-8. Epub 2017 Nov 6. PMID: 29106302
Article Published Date : Nov 05, 2017
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Cardiovascular Diseases, Endothelial Dysfunction
Pharmacological Actions : Cardioprotective
Additional Keywords : Risk Reduction
[+]

Apple extracts assisted in protecting the gastric mucosa following acute aspirin administrationJul 27, 2014

Pubmed Data : Phytother Res. 2014 Jul 28. Epub 2014 Jul 28. PMID: 25069887
Article Published Date : Jul 27, 2014
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols, Apples
Diseases : Aspirin-Induced Toxicity
Pharmacological Actions : Gastroprotective
Additional Keywords : Plant Extracts
[+]

Apple extracts can extend cellular lifespan by lowering the level of intracellular ROS and by the activation of cellular signalling pathways.Apr 04, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2017 Apr 5 ;17(1):200. Epub 2017 Apr 5. PMID: 28381226
Article Published Date : Apr 04, 2017
Study Type : Animal Study
Additional Links
Substances : Apple, Apple Polyphenols
Diseases : Aging, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants
Additional Keywords : Plant Extracts
[+]

Apple peel might be regarded as a preventive and therapeutic product for the amelioration of HC diet-induced vascular dysfunction and hepatic injury.Feb 26, 2017

Pubmed Data : Food Funct. 2017 Feb 27. Epub 2017 Feb 27. PMID: 28239698
Article Published Date : Feb 26, 2017
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Endothelial Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Cholinesterase Inhibitor Drugs
[+]

Apple peel polyphenols reduce mitochondrial dysfunction in mice with DSS-induced ulcerative colitis.Mar 20, 2018

Pubmed Data : J Nutr Biochem. 2018 Mar 21 ;57:56-66. Epub 2018 Mar 21. PMID: 29674247
Article Published Date : Mar 20, 2018
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Inflammatory Bowel Diseases, Mitochondrial Dysfunction , Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Apple polyphenol extract alleviates high-fat-diet-induced hepatic steatosis.Oct 22, 2019

Pubmed Data : J Agric Food Chem. 2019 Oct 23. Epub 2019 Oct 23. PMID: 31608624
Article Published Date : Oct 22, 2019
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Hepatic Steatosis, High Fat Diet
Pharmacological Actions : Hepatoprotective, MicroRNA modulator
[+]

Apple polyphenol extract improves high-fat diet-induced hepatic steatosis.Jun 22, 2021

Pubmed Data : J Agric Food Chem. 2021 Jun 23 ;69(24):6829-6841. Epub 2021 Jun 14. PMID: 34124904
Article Published Date : Jun 22, 2021
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Hepatic Steatosis, High Fat Diet
Pharmacological Actions : Gastrointestinal Agents, Hepatoprotective
[+]

Apple polyphenol extract modulates bile acid metabolism and gut microbiota.Feb 16, 2022

Pubmed Data : Food Funct. 2022 Feb 17. Epub 2022 Feb 17. PMID: 35174840
Article Published Date : Feb 16, 2022
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Circadian Dysregulation, High Fat Diet
Pharmacological Actions : Gastrointestinal Agents
[+]

Apple polyphenol extract suppresses Clostridioides difficile infection in a mouse model.Oct 29, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Metabolites. 2022 Oct 30 ;12(11). Epub 2022 Oct 30. PMID: 36355125
Article Published Date : Oct 29, 2022
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Clostridium Infections
Pharmacological Actions : Gastrointestinal Agents
[+]

Apple polyphenol extracts have neuroprotective effects against Aluminum induced biotoxicity.Nov 30, 2014

Pubmed Data : Neurotoxicology. 2014 Dec ;45:111-20. Epub 2014 Oct 17. PMID: 25445564
Article Published Date : Nov 30, 2014
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols, Polyphenols
Diseases : Aluminum Toxicity , Oxidative Stress
Pharmacological Actions : Chelating Agents, Neuroprotective Agents
Additional Keywords : Chelation, Plant Extracts
[+]

Apple polyphenol extracts might emerge as a promising nutritional ingredient in the management of chronic diseases such as diabetes.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Metab (Lond). 2016 ;13:32. Epub 2016 Apr 30. PMID: 27141227
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Insulin Resistance
Pharmacological Actions : Insulin Sensitizers
Additional Keywords : Natural Substance Synergy, Plant Extracts
[+]

Apple polyphenol may reduce the adverse effects of the immunization adjuvant cholera toxin. Jul 30, 2009

Pubmed Data : Vaccine. 2009 Jul 30;27(35):4808-17. Epub 2009 Jun 17. PMID: 19539583
Article Published Date : Jul 30, 2009
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols, Apples, Polyphenols
Diseases : Cholera, Vaccine-induced Toxicity
Additional Keywords : Drug Side Effect Attenuation
[+]

Apple polyphenol relieves hypoxia-induced pulmonary arterial hypertension.Oct 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Nov ;107:937-944. Epub 2018 Aug 23. PMID: 30257406
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Hypertension: Pulmonary, Hypoxia
Pharmacological Actions : Antihypertensive Agents, Vasodilator Agents
[+]

Apple polyphenols exert protective effects against Con A-induced immunological liver injury.Aug 23, 2016

Pubmed Data : Chem Biol Interact. 2016 Aug 24. Epub 2016 Aug 24. PMID: 27567545
Article Published Date : Aug 23, 2016
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interferon Gamma Reducer, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Concanavalin A
[+]

Apple polyphenols exhibits chondroprotective changes of synovium and prevents knee osteoarthritis.May 06, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochem Biophys Res Commun. 2022 May 7 ;614:120-124. Epub 2022 May 7. PMID: 35580540
Article Published Date : May 06, 2022
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chondroprotective
[+]

Apple polyphenols extract (APE) improves colon damage in a rat model of colitis.Feb 28, 2012

Pubmed Data : Dig Liver Dis. 2012 Feb 28. Epub 2012 Feb 28. PMID: 22381211
Article Published Date : Feb 28, 2012
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Apple polyphenols extract alleviated dextran sulfate sodium induced acute ulcerative colitis.Nov 04, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2021 Nov 5 ;10(11). Epub 2021 Nov 5. PMID: 34828992
Article Published Date : Nov 04, 2021
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Brain Inflammation , Ulcerative Colitis
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents
[+]

Apple polyphenols extract alleviated dextran sulfate sodium-induced ulcerative colitis.Nov 19, 2020

Pubmed Data : Phytother Res. 2020 Nov 20. Epub 2020 Nov 20. PMID: 33215776
Article Published Date : Nov 19, 2020
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Dysbiosis, Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents, NF-kappaB Inhibitor
[+]

Apple polyphenols extracts ameliorate high carbohydrate diet-induced body weight gain.Dec 21, 2021

Pubmed Data : J Agric Food Chem. 2021 Dec 22. Epub 2021 Dec 22. PMID: 34935369
Article Published Date : Dec 21, 2021
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : High Fat Diet, Obesity
Additional Keywords : Anti-Obesity Agents
[+]

Apple polyphenols induce browning of white adipose tissue.Nov 22, 2019

Pubmed Data : J Nutr Biochem. 2019 Nov 23 ;77:108299. Epub 2019 Nov 23. PMID: 31841959
Article Published Date : Nov 22, 2019
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents
[+]

Apple polyphenols suppresses indomethacin-induced gastric damage.Oct 31, 2017

Pubmed Data : J Med Food. 2017 Nov ;20(11):1113-1120. PMID: 29120271
Article Published Date : Oct 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Drug-Induced Toxicity: Indomethacin
Pharmacological Actions : Antioxidants, Gastroprotective
Problem Substances : Indomethacin
[+]

Apple procyanidins are promising food components that inhibit osteoarthritis progression.May 07, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2018 May 8 ;8(1):7229. Epub 2018 May 8. PMID: 29739985
Article Published Date : May 07, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective
[+]

Dietary apple polyphenols intake increased endurance based on fiber-type composition in rat muscle.Dec 31, 2014

Pubmed Data : PLoS One. 2015;10(7):e0134303. Epub 2015 Jul 29. PMID: 26222548
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Muscle Fatigue
[+]

Dietary apple polyphenols promote fat browning in high-fat diet-induced obese mice.Jan 08, 2020

Pubmed Data : J Sci Food Agric. 2020 Jan 9. Epub 2020 Jan 9. PMID: 31916584
Article Published Date : Jan 08, 2020
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents
[+]

Effects of apple polyphenols on monocrotaline-induced pulmonary vascular remodeling in rats and its mechanism.May 27, 2019

Pubmed Data : Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2019 May 28 ;35(3):209-214. PMID: 31257800
Article Published Date : May 27, 2019
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Hypertension: Pulmonary
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Polymerized catechin compounds in apple polyphenol extracts inhibit the biological and enzymatic activities of cholera toxin.Dec 31, 2001

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Microbiol Immunol. 2002 ;46(4):249-55. PMID: 12061627
Article Published Date : Dec 31, 2001
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols, Catechin , Flavonoids
Diseases : Cholera
Pharmacological Actions : Antidiarrheals, Antimicrobial, Enzyme Inhibitors
Additional Keywords : Dose Response, Plant Extracts
[+]

Preventive effect of apple polyphenol extract on high-fat diet-induced hepatic steatosis.Feb 28, 2022

Pubmed Data : J Agric Food Chem. 2022 Mar 1. Epub 2022 Mar 1. PMID: 35227062
Article Published Date : Feb 28, 2022
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Hepatic Steatosis, High Fat Diet
Pharmacological Actions : Hepatoprotective, Hypolipidemic
[+]

Protective effect of Apple polyphenols on chronic ethanol exposure.Apr 27, 2020

Pubmed Data : Chem Biol Interact. 2020 Apr 28 ;326:109113. Epub 2020 Apr 28. PMID: 32360496
Article Published Date : Apr 27, 2020
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Alcohol Toxicity , Brain: Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Protective effects of apple polyphenols on bone loss in mice with high fat diet-induced obesity.Jul 04, 2022

Pubmed Data : Food Funct. 2022 Jul 5. Epub 2022 Jul 5. PMID: 35788787
Article Published Date : Jul 04, 2022
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : High Fat Diet, Obesity, Osteoporosis
Pharmacological Actions : Osteoprotective
[+]

The ameliorating effects of apple polyphenol extract on high-fat-diet-induced hepatic steatosis Are SIRT1-dependent.May 10, 2022

Pubmed Data : J Agric Food Chem. 2022 May 11 ;70(18):5579-5594. Epub 2022 Apr 29. PMID: 35485931
Article Published Date : May 10, 2022
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Hepatic Steatosis, High Fat Diet
Pharmacological Actions : Gastrointestinal Agents, Hepatoprotective, SIRT1 Activator
[+]

The preventive and therapeutic effects of DAPP may be clinically feasible in individuals with intestinal inflammatory bowel diseases.Sep 13, 2016

Pubmed Data : Clin Sci (Lond). 2016 Sep 14. Epub 2016 Sep 14. PMID: 27630205
Article Published Date : Sep 13, 2016
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

The results of the present study revealed the hepatoprotective efficacy of APE by inhibiting carbon tetrachloride induced apoptosis.Jan 24, 2016

Pubmed Data : Hum Exp Toxicol. 2016 Jan 25. Epub 2016 Jan 25. PMID: 26811344
Article Published Date : Jan 24, 2016
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols, Apples
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective
Additional Keywords : Dose Response
[+]

These results proved this ancient Italian apple is a source of nutraceuticals able to protect/prevent damage from brain ischemia.Oct 28, 2021

Pubmed Data : Pharmaceuticals (Basel). 2021 Oct 29 ;14(11). Epub 2021 Oct 29. PMID: 34832888
Article Published Date : Oct 28, 2021
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Brain Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results suggest that the apple polyphenols are a beneficial nutritional supplement for the attenuation of atherosclerosis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2015 ;7(8):7085-105. Epub 2015 Aug 24. PMID: 26305254
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Atherosclerosis, Endothelial Dysfunction, Hepatic Steatosis
Pharmacological Actions : Anti-atherogenic, Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Hepatoprotective, Superoxide Dismutase Up-regulation
[+]

A boost in mitochondrial activity underpins the cholesterol-lowering effect of apple polyphenols on hepatic cells.Jan 13, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Jan 14 ;11(1). Epub 2019 Jan 14. PMID: 30646510
Article Published Date : Jan 13, 2019
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols, Procyanidin B2
Diseases : Hypercholesterolemia
Pharmacological Actions : Anticholesteremic Agents
[+]

A review of the health supplements for allergic rhinitis.May 31, 2020

Pubmed Data : Complement Ther Med. 2020 Jun ;51:102425. Epub 2020 May 17. PMID: 32507438
Article Published Date : May 31, 2020
Study Type : Review
Additional Links
Substances : Apple Polyphenols, Chlorophyll, Honey, Perillaldehyde, Quercetin, Spirulina, Tomato, Vitamin C, Vitamin D, Vitamin E
Diseases : Allergic Rhinitis
Pharmacological Actions : Anti-Allergic Agents
[+]

An apple flavonoid enriched fraction possessed a significantly stronger antiproliferative and specific action than Sorafenib in vitro.Sep 24, 2014

Pubmed Data : Nutr Cancer. 2014 Sep 25:1-10. Epub 2014 Sep 25. PMID: 25256427
Article Published Date : Sep 24, 2014
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols, Flavonoids
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Cell cycle arrest, Chemopreventive, Topoisomerase II Inhibitor
Additional Keywords : Northern Spy Apples, Plant Extracts, Selective Cytotoxicity
[+]

Annurca apple polyphenol extract affects acetyl-cholinesterase and mono-amine oxidase in vitro enzyme activity.Jan 13, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2021 Jan 14 ;14(1). Epub 2021 Jan 14. PMID: 33466604
Article Published Date : Jan 13, 2021
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Aging: Brain , Neurodegenerative Diseases
Pharmacological Actions : Acetylcholinesterase Inhibitor, Enzyme Inhibitors, Neuroprotective Agents
[+]

Annurca apple polyphenol extract promotes mesenchymal-to-epithelial transition and inhibits migration in triple-negative breast cancer cells.Sep 27, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2020 Sep 28 ;10(1):15921. Epub 2020 Sep 28. PMID: 32985606
Article Published Date : Sep 27, 2020
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Annurca apple polyphenol extract selectively kills MDA-MB-231 cells.Sep 09, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 Sep 10 ;9(1):13045. Epub 2019 Sep 10. PMID: 31506575
Article Published Date : Sep 09, 2019
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation, Cell cycle arrest
Additional Keywords : Selective Cytotoxicity
[+]

Annurca apple polyphenol extract strongly inhibits the proliferation of MCF-7 cells by inducing G2/M cell cycle arrest and apoptosis.Aug 31, 2017

Pubmed Data : Int J Oncol. 2017 Sep ;51(3):939-948. Epub 2017 Jul 31. PMID: 28766690
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

Annurca apple polyphenols ignite keratin production in hair follicles.Oct 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Oct 2 ;10(10). Epub 2018 Oct 2. PMID: 30279339
Article Published Date : Oct 01, 2018
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Hair Loss
[+]

Annurca apple polyphenols protect murine hair follicles from taxane induced dystrophy.Nov 19, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Nov 20 ;10(11). Epub 2018 Nov 20. PMID: 30463345
Article Published Date : Nov 19, 2018
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Chemotherapy and Radiation Toxicity
Pharmacological Actions : Chemoprotective Agents
[+]

Apple and Hop-polyphenols inhibit P. gingivalis-mediated precursor of MMP-9 activation and invasion of oral squamous cell carcinoma cells.May 12, 2016

Pubmed Data : J Periodontol. 2016 May 13:1-21. Epub 2016 May 13. PMID: 27177287
Article Published Date : May 12, 2016
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols, Hops
Diseases : Oral Cancer, Periodontal Diseases, Squamous cell carcinoma
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Apple extracts inhibit the WNT pathway in colon cells carrying familial adenomatous polyposismutations.Nov 17, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Nov 18 ;9(11). Epub 2017 Nov 18. PMID: 29156563
Article Published Date : Nov 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Colon Cancer
Pharmacological Actions : Chemopreventive, Wnt/β-catenin pathway down-regulation
[+]

Apple polyphenol extract alleviates lipid accumulation in free-fatty-acid-exposed HepG2 cells.Oct 08, 2020

Pubmed Data : Phytother Res. 2020 Oct 9. Epub 2020 Oct 9. PMID: 33037751
Article Published Date : Oct 08, 2020
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Autophagy Up-regulation, Hepatoprotective, Hypolipidemic
[+]

Apple polyphenol inhibited the vitality, cell growth and proliferation, and migration of breast cancer cells MDA-MB-231Oct 31, 2017

Pubmed Data : Wei Sheng Yan Jiu. 2017 Nov ;46(6):960-964. PMID: 29903207
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Bioactive compounds isolated from apple, tea, and ginger protect against dicarbonyl induced stress in cultured human retinal epithelial cells.Feb 14, 2016

Pubmed Data : Phytomedicine. 2016 Feb 15 ;23(2):200-13. Epub 2016 Jan 5. PMID: 26926182
Article Published Date : Feb 14, 2016
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols, EGCG (Epigallocatechin gallate), Ginger
Diseases : Advanced Glycation End products (AGE), Diabetic Complications
Pharmacological Actions : Anti-Glycation Agents, Antioxidants, Nrf2 activation
[+]

Effects of Annurca flesh apple polyphenols in human thyroid cancer cell lines.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:6268755. Epub 2022 Feb 17. PMID: 35222800
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Thyroid Cancer
Pharmacological Actions : Antioxidants, Chemotherapeutic, MicroRNA modulator
[+]

Flavonoids from Pink Lady apples can inhibit cancer cell growth in human colon cancer LoVo cells and breast cancer MCF-7 cells.Sep 28, 2015

Pubmed Data : Food Funct. 2015 Sep 29. Epub 2015 Sep 29. PMID: 26416794
Article Published Date : Sep 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Breast Cancer, Colon Cancer
Pharmacological Actions : Antioxidants, Apoptotic
Additional Keywords : Dose Response
[+]

Induction of hair keratins expression by an Annurca apple-based nutraceutical formulation in human follicular cells.Dec 12, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Dec 13 ;11(12). Epub 2019 Dec 13. PMID: 31847069
Article Published Date : Dec 12, 2019
Study Type : In Vitro Study
Additional Links
Substances : Apple, Apple Polyphenols, Procyanidin B2
Diseases : Hair Loss
Pharmacological Actions : Antioxidants
[+]

Influence of apple polyphenols on inflammatory gene expression.Sep 30, 2009

Pubmed Data : Mol Nutr Food Res. 2009 Oct ;53(10):1263-80. PMID: 19764067
Article Published Date : Sep 30, 2009
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Gastrointestinal Inflammation, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Inhibitory properties of polyphenols in Malus "Winter Red" crabapple fruit on α-glucosidase and α-amylase using improved methods.Sep 17, 2021

Pubmed Data : J Food Biochem. 2021 Sep 18:e13942. Epub 2021 Sep 18. PMID: 34535900
Article Published Date : Sep 17, 2021
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Hyperglycemia
Pharmacological Actions : Alpha-amylase inhibitor, Alpha-glucosidase inhibitor , Hypoglycemic Agents
[+]

Phenolics from Fuji apple showed good antioxidant, antibacterial, and antiproliferative activities.Jun 05, 2016

Pubmed Data : J Food Sci. 2016 Jun 6. Epub 2016 Jun 6. PMID: 27272442
Article Published Date : Jun 05, 2016
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Colon Cancer, Escherichia coli Infections, Listeria Infections, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents, Antioxidants, Antiproliferative
[+]

Protection of polyphenols against glyco-oxidative stress.Oct 15, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Oct 16 ;9(10). Epub 2020 Oct 16. PMID: 33081239
Article Published Date : Oct 15, 2020
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Glutathione Upregulation
[+]

The chemo-preventive effects of apple extracts in human pathologies may act similarly to some classes of anticancer drugs.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 ;6:32516. Epub 2016 Sep 2. PMID: 27587238
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols, Apples
Diseases : Colorectal Cancer
Pharmacological Actions : Antioxidants, Chemopreventive
[+]

This review will focus on the reciprocal interaction between apple components and the gut microbiota and the potential link to cardiovascular health and the possible mechanisms of action.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2015;7(6):3959-3998. Epub 2015 May 26. PMID: 26016654
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Apple Polyphenols, Apples
Diseases : Cardiovascular Disease: Prevention, Cardiovascular Diseases
Pharmacological Actions : Cardioprotective
Additional Keywords : Microbiota
[+]

Young apple polyphenols as natural α-glucosidase inhibitors.Jan 27, 2020

Pubmed Data : Bioorg Chem. 2020 Jan 28 ;96:103625. Epub 2020 Jan 28. PMID: 32028059
Article Published Date : Jan 27, 2020
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Alpha-glucosidase inhibitor

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