Asiatic Acid

Views 103
Jump to
Abstracts Focused Research Topics
Your Token Count0

Sign in to Purchase/Download Documents

Sign in / Register

Focus Your Research

Click any topic below to filter + focus research
2 Diseases Researched for Asiatic Acid
NameACCKFocus
Lung Cancer11Locked
Melanoma11Locked
2 Pharmacological Actions Researched for Asiatic Acid
NameACCKFocus
Antiproliferative 11Locked
Immunomodulatory11Locked

View the Evidence:
110 Abstracts with Asiatic Acid Research

[+]

Antidiabetic and antihyperlipidemic activity of asiatic acid in diabetic rats.Feb 14, 2014

Pubmed Data : Phytomedicine. 2014 Feb 15 ;21(3):225-32. Epub 2013 Sep 24. PMID: 24075211
Article Published Date : Feb 14, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Diabetes Mellitus: Type 2, Hyperlipidemia
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Natural Substances Versus Drugs
[+]

Antiobesity efficacy of asiatic acid.Feb 09, 2019

Pubmed Data : Arch Physiol Biochem. 2019 Feb 10:1-10. Epub 2019 Feb 10. PMID: 30739501
Article Published Date : Feb 09, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Obesity Agents
[+]

Asiatic acid alleviates cardiovascular remodelling in rats with L-NAME-induced hypertension.Oct 31, 2015

Pubmed Data : Clin Exp Pharmacol Physiol. 2015 Nov ;42(11):1189-97. PMID: 26234646
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents, Cardioprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Sodium Nitrate
[+]

Asiatic acid alleviates non-alcoholic fatty liver.Nov 30, 2018

Pubmed Data : Int Immunopharmacol. 2018 Dec ;65:256-267. Epub 2018 Oct 17. PMID: 30340105
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor
[+]

Asiatic acid ameliorates doxorubicin-induced cardiac and hepato-renal toxicities.Mar 31, 2018

Pubmed Data : Cardiovasc Toxicol. 2018 Apr ;18(2):131-141. PMID: 28856520
Article Published Date : Mar 31, 2018
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents, Hepatoprotective, Nrf2 activation
[+]

Asiatic acid ameliorates hepatic ischemia-reperfusion injury.Dec 31, 2017

Pubmed Data : Toxicol Appl Pharmacol. 2018 01 1 ;338:214-223. Epub 2017 Nov 28. PMID: 29196105
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation
[+]

Asiatic acid ameliorates obesity-related osteoarthritis by inhibiting myeloid differentiation protein-2.Jun 23, 2020

Pubmed Data : Food Funct. 2020 Jun 24 ;11(6):5513-5524. PMID: 32514515
Article Published Date : Jun 23, 2020
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Obesity, Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, NF-kappaB Inhibitor
[+]

Asiatic acid and maslinic acid protected heart via anti-glycative and anti-coagulatory activities in diabetic mice.Aug 31, 2015

Pubmed Data : Food Funct. 2015 Sep ;6(9):2967-74. PMID: 26190771
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Diabetes: Cardiovascular Illness
Pharmacological Actions : Cardioprotective, NF-kappaB Inhibitor
[+]

Asiatic acid and naringenin may represent as a novel and effective therapy for chronic kidney disease associated with fibrosis.Nov 09, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Nov 10 ;6(35):36984-97. PMID: 26474462
Article Published Date : Nov 09, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid, Naringenin
Diseases : Chronic Kidney Disease (CKD), Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Asiatic acid attenuates cardiac hypertrophy.Jul 31, 2014

Pubmed Data : Int J Mol Med. 2014 Aug ;34(2):499-506. Epub 2014 May 14. PMID: 24827470
Article Published Date : Jul 31, 2014
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective, Transforming growth factor beta (TGF-β) inhibitor
[+]

Asiatic acid attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells.Apr 30, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharmacol Sin. 2012 May ;33(5):578-87. Epub 2012 Mar 26. PMID: 22447225
Article Published Date : Apr 30, 2012
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Cognitive Decline/Dysfunction, Dementia, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Apoptotic, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

Asiatic acid attenuates high-fat diet-induced impaired spermatogenesis.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Mar ;15(3):2397-2403. Epub 2017 Dec 22. PMID: 29467846
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : High Fat Diet, Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Anti-Apoptotic
[+]

Asiatic acid attenuates pressure overload-induced cardiac fibrosis.Jun 25, 2019

Pubmed Data : Int Immunopharmacol. 2019 Jun 26 ;74:105712. Epub 2019 Jun 26. PMID: 31254954
Article Published Date : Jun 25, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Hypertension, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Asiatic acid attenuates renin-angiotensin system activation and improves vascular function.Apr 26, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2016 Apr 27 ;16:123. Epub 2016 Apr 27. PMID: 27121076
Article Published Date : Apr 26, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : High Fat Diet, Metabolic Syndrome X
Pharmacological Actions : Antihypertensive Agents
[+]

Asiatic acid attenuates the progression of left ventricular hypertrophy and heart failure induced by pressure overload.Nov 30, 2015

Pubmed Data : J Cardiovasc Pharmacol. 2015 Dec ;66(6):558-68. PMID: 26647013
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Cardiac Hypertrophy, Heart Failure
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-6 Downregulation
[+]

Asiatic acid can enhance spatial memory after administration for 28 days.Oct 04, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2015 Oct 5 ;7(10):8413-23. Epub 2015 Oct 5. PMID: 26445061
Article Published Date : Oct 04, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Memory Disorders
Pharmacological Actions : Antioxidants, Neurogenesis, Neuroprotective Agents
[+]

Asiatic acid could be able to modulate various pathological features of Alzheimer's disease and could hold promise in its treatment.Jan 21, 2019

Pubmed Data : Neurotox Res. 2019 Jan 22. Epub 2019 Jan 22. PMID: 30671870
Article Published Date : Jan 21, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Aluminum Toxicity , Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
Problem Substances : Aluminum Chloride
[+]

Asiatic acid could be used as an effective chemopreventive agent against 1,2-dimethylhydrazine induced colon carcinogenesis.Dec 24, 2017

Pubmed Data : Chem Biol Interact. 2017 Dec 25 ;278:197-211. Epub 2017 Nov 6. PMID: 29108773
Article Published Date : Dec 24, 2017
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Colon Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemopreventive
[+]

Asiatic acid has neuroprotective properties against 5-fluorouracil chemotherapy.Aug 08, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Aug 9 ;10(8). Epub 2018 Aug 9. PMID: 30096914
Article Published Date : Aug 08, 2018
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Chemotherapy-Induced Toxicity: 5-fluorouracil
Pharmacological Actions : Chemoprotective Agents, Neuroprotective Agents
[+]

Asiatic acid has the potential to treat inflammatory disease such as COPD.Sep 30, 2016

Pubmed Data : Int Immunopharmacol. 2016 Oct ;39:208-217. Epub 2016 Aug 3. PMID: 27494684
Article Published Date : Sep 30, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Chronic Obstructive Pulmonary Disease, Smoking
Pharmacological Actions : Superoxide Dismutase Up-regulation
[+]

Asiatic acid improved metabolic, hemodynamic abnormalities in metabolic syndrome rats.Jan 15, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2014 Jan 16 ;6(1):355-70. Epub 2014 Jan 16. PMID: 24441717
Article Published Date : Jan 15, 2014
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Inflammation, Insulin Resistance, Metabolic Syndrome X, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cellsOct 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Carcinog. 2015 Nov ;54(11):1417-29. Epub 2014 Sep 22. PMID: 25252179
Article Published Date : Oct 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Glioblastoma
Pharmacological Actions : Apoptotic
[+]

Asiatic acid inhibits lipopolysaccharide-induced acute lung injury in mice.Sep 30, 2016

Pubmed Data : Inflammation. 2016 Oct ;39(5):1642-8. PMID: 27395046
Article Published Date : Sep 30, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Asiatic acid inhibits lliver fibrosis.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(2):e31350. Epub 2012 Feb 7. PMID: 22363627
Article Published Date : Dec 31, 2011
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Liver Cirrhosis
Pharmacological Actions : Anti-Fibrotic
[+]

Asiatic acid inhibits OVX-induced osteoporosis and osteoclastogenesis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:331. Epub 2020 Mar 27. PMID: 32292339
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
[+]

Asiatic acid is a potent nutraceutical agent against the progression of Parkinson's disease.Mar 31, 2016

Pubmed Data : Food Funct. 2016 Apr ;7(4):1999-2005. PMID: 26999333
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Asiatic acid is neuroprotective in a mouse model of focal cerebral ischemia.Aug 14, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neurosci Res. 2009 Aug 15 ;87(11):2541-50. PMID: 19382233
Article Published Date : Aug 14, 2009
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Cerebral Ischemia
Pharmacological Actions : Neuroprotective Agents
[+]

Asiatic acid may be a novel candidate for development as a therapy for myocardial infarction.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Jan ;11(1):57-64. Epub 2015 Nov 17. PMID: 26889217
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Myocardial Infarction
Pharmacological Actions : Cardioprotective
[+]

Asiatic acid may be a novel therapeutic agent for cardiac hypertrophy.Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Thorac Dis. 2015 Oct ;7(10):1787-97. PMID: 26623102
Article Published Date : Sep 30, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
[+]

Asiatic acid may be a potential anti-resorptive agent for postmenopausal osteoporosis.Aug 20, 2019

Pubmed Data : Calcif Tissue Int. 2019 Aug 21. Epub 2019 Aug 21. PMID: 31435709
Article Published Date : Aug 20, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Osteoporosis, Postmenopausal Disorders
Pharmacological Actions : Osteoprotective
[+]

Asiatic acid may be a potential therapeutic agent for glaucoma.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurosci. 2018 ;12:489. Epub 2018 Jul 20. PMID: 30079010
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Glaucoma
Pharmacological Actions : Anti-Apoptotic
[+]

Asiatic acid may be a replacement alternative for chloroquine treatment with concomitant amelioration of malaria pathophysiology. Sep 12, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2016 Sep 13 ;16:357. Epub 2016 Sep 13. PMID: 27618936
Article Published Date : Sep 12, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Anemia, Malaria
Pharmacological Actions : Anti-Inflammatory Agents, Antiparasitic Agents
[+]

Asiatic acid mitigates hyperglycemia and reduces islet fibrosis in a spontaneous type 2 diabetic animal model.Jun 30, 2015

Pubmed Data : Chin J Nat Med. 2015 Jul ;13(7):529-34. PMID: 26233843
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Diabetes Mellitus: Type 2, Insulin Resistance
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Asiatic acid possesses significant anti-obesity potential.Apr 30, 2018

Pubmed Data : Mol Cell Biochem. 2018 May ;442(1-2):143-154. Epub 2017 Oct 9. PMID: 28993954
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Obesity
Pharmacological Actions : Antioxidants, Hypolipidemic, MicroRNA modulator
Additional Keywords : Anti-Obesity Agents
[+]

Asiatic acid prevents oxidative stress and apoptosis by inhibiting the translocation of α-synuclein into mitochondria.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurosci. 2018 ;12:431. Epub 2018 Jun 28. PMID: 30002614
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Parkinson's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Asiatic acid prevents the development of interstitial lung disease in a hypochlorous acid-induced mouse model of scleroderma.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Jun ;15(6):8711-8716. Epub 2018 Apr 2. PMID: 29805609
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Scleroderma
Pharmacological Actions : Antioxidants
[+]

Asiatic acid prevents the quinolinic acid-induced oxidative stress and cognitive impairment.Jan 31, 2018

Pubmed Data : Metab Brain Dis. 2018 Feb ;33(1):151-159. Epub 2017 Oct 31. PMID: 29086235
Article Published Date : Jan 31, 2018
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Cognitive Decline/Dysfunction
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Asiatic acid protects against cardiac hypertrophy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Sci. 2016 ;12(7):861-71. Epub 2016 May 25. PMID: 27313499
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Cardiac Hypertrophy, Heart Failure
Pharmacological Actions : Cardioprotective
[+]

Asiatic acid protects against cisplatin-induced acute kidney injury via anti-apoptosis and anti-inflammation.Oct 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Nov ;107:1354-1362. Epub 2018 Aug 30. PMID: 30257350
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Chemoprotective Agents
[+]

Asiatic acid protects against doxorubicin-induced cardiotoxicity.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:5347204. Epub 2020 May 15. PMID: 32509145
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Cardioprotective, Chemoprotective Agents
[+]

Asiatic acid reduces blood pressure by enhancing nitric oxide bioavailability.Sep 30, 2014

Pubmed Data : Phytother Res. 2014 Oct ;28(10):1506-12. Epub 2014 Apr 11. PMID: 24723332
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Hypertension, Oxidative Stress
Pharmacological Actions : Antihypertensive Agents, Malondialdehyde Down-regulation, Nitric Oxide Enhancer
[+]

Combination of carnosine and asiatic acid provided greater anti-inflammatory protection for HUVE cells and diabetic mice.Feb 21, 2019

Pubmed Data : Food Chem Toxicol. 2019 Feb 22. Epub 2019 Feb 22. PMID: 30802477
Article Published Date : Feb 21, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid, Carnosine
Diseases : Diabetic Complications, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substance Synergy
[+]

Effect and mechanism of asiatic acid on autophagy in myocardial ischemia-reperfusion injury in vivo and in vitro.Oct 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2020 Nov ;20(5):54. Epub 2020 Sep 4. PMID: 32952644
Article Published Date : Oct 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Myocardial Ischemia
Pharmacological Actions : Autophagy Inhibitors, Cardioprotective
[+]

Evaluation of the anxiolytic and antidepressant effects of asiatic acid.Mar 31, 2015

Pubmed Data : AANA J. 2015 Apr ;83(2):91-8. PMID: 26016167
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid, Gotu Kola
Diseases : Anxiety Disorders, Depression
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
Additional Keywords : Phytotherapy
[+]

Mechanism underlying mitochondrial protection of asiatic acid against hepatotoxicity in mice.Jan 31, 2006

Pubmed Data : J Pharm Pharmacol. 2006 Feb ;58(2):227-33. PMID: 16451751
Article Published Date : Jan 31, 2006
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Lipopolysaccharide-Induced Toxicity, Liver Damage
Pharmacological Actions : Hepatoprotective
[+]

Neuroprotective effect of asiatic acid against spinal cord injury in rats.Jul 14, 2016

Pubmed Data : Life Sci. 2016 Jul 15 ;157:45-51. Epub 2016 May 3. PMID: 27153777
Article Published Date : Jul 14, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Neuroprotective effect of asiatic acid in rat model of focal embolic stroke.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2014 ;37(8):1397-401. PMID: 25087961
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions : Neuroprotective Agents
[+]

Protective effect of asiatic acid from Potentilla chinensis on alcohol hepatic injury.Jun 30, 2015

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2015 Jul ;40(14):2866-70. PMID: 26666041
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Protective effect of asiatic acid in an experimental cerulein-induced model of acute pancreatitis in miceDec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2017 ;9(8):3842-3852. Epub 2017 Aug 15. PMID: 28861174
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Pancreatitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Protective effects of asiatic acid against pelvic inflammatory disease in rats.May 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2019 Jun ;17(6):4687-4692. Epub 2019 Apr 17. PMID: 31086602
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Pelvic Inflammatory Disease
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Protective effects of asiatic acid in a spontaneous type 2 diabetic mouse model.Jul 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2017 Aug ;16(2):1333-1339. Epub 2017 Jun 2. PMID: 28586016
Article Published Date : Jul 31, 2017
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents, MicroRNA modulator
[+]

The use of asiatic acid may be a potential efficient therapeutic strategy for the treatment of spinal cord injury-induced acute lung injury.Nov 30, 2016

Pubmed Data : Inflammation. 2016 Dec ;39(6):1853-1861. PMID: 27605220
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Inflammation, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation
[+]

There is an excellent prospect of using asiatic acid to treat diabetic nephropathy.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2018 ;10(11):3733-3741. Epub 2018 Nov 15. PMID: 30662623
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Diabetic Nephropathy
Pharmacological Actions : Renoprotective
[+]

These findings demonstrated that asiatic acid exerts beneficial effects on myocardial ischemia/reperfusion injury.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2018 ;12:3573-3582. Epub 2018 Oct 25. PMID: 30498333
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

These findings indicate that asiatic acid is an antihypertensive agent that ameliorates hemodynamic alterations in 2K-1C hypertensive rats.Sep 30, 2017

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2017 Oct ;390(10):1073-1083. Epub 2017 Jul 21. PMID: 28733880
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Hypertension
Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Antioxidants, NF-kappaB Inhibitor
[+]

These findings indicated that the supplement of asiatic acid might be beneficial to the prevention or alleviation of brain aging.Jan 31, 2015

Pubmed Data : Food Funct. 2015 Feb ;6(2):542-8. PMID: 25504333
Article Published Date : Jan 31, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Aging, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These findings suggest that asiatic acid prevents the progression of liver fibrosis.Jun 30, 2018

Pubmed Data : Int Immunopharmacol. 2018 Jul ;60:1-8. Epub 2018 Apr 24. PMID: 29702278
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

These results demonstrate that asiatic acid ameliorates carbon tetrachloride-induced liver fibrosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2018 ;12:3595-3605. Epub 2018 Oct 26. PMID: 30464391
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, NF-kappaB Inhibitor, Nrf2 activation
[+]

These results provide new insight into the anti-fibrotic mechanism of asiatic acid.Nov 07, 2019

Pubmed Data : Acta Pharmacol Sin. 2019 Nov 8. Epub 2019 Nov 8. PMID: 31705123
Article Published Date : Nov 07, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

These results suggest that asiatic acid is a potent hepatic protective agent against high-fat diet-induced hepatic injury.May 20, 2014

Pubmed Data : J Agric Food Chem. 2014 May 21 ;62(20):4625-31. Epub 2014 May 6. PMID: 24779966
Article Published Date : May 20, 2014
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Fatty Liver, Insulin Resistance, Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

This study concluded that asiatic acid can protect against renal dysfunction.Jan 30, 2020

Pubmed Data : Cardiovasc Hematol Agents Med Chem. 2020 Jan 31. Epub 2020 Jan 31. PMID: 32003703
Article Published Date : Jan 30, 2020
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Diabetic Nephropathy
Pharmacological Actions : Renoprotective
[+]

This study shows asiatic acid is effective against multiple models of focal ischemia.May 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Stroke. 2012 Jun ;43(6):1632-8. Epub 2012 Apr 17. PMID: 22511009
Article Published Date : May 31, 2012
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Stroke
Pharmacological Actions : Matrix metalloproteinase-9 (MMP-9) inhibitor, Neuroprotective Agents
[+]

A pharmacological review on asiatic acid and its derivatives.Mar 31, 2018

Pubmed Data : SLAS Technol. 2018 Apr ;23(2):111-127. Epub 2018 Jan 23. PMID: 29361877
Article Published Date : Mar 31, 2018
Study Type : Review
Additional Links
Substances : Asiatic Acid, Gotu Kola
Diseases : Chronic Disease
[+]

Anti-glioma activity and the mechanism of cellular uptake of asiatic acid-loaded solid lipid nanoparticles.Mar 15, 2016

Pubmed Data : Int J Pharm. 2016 Mar 16 ;500(1-2):305-15. Epub 2016 Jan 13. PMID: 26775062
Article Published Date : Mar 15, 2016
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Glioma
Pharmacological Actions : Antineoplastic Agents, Apoptotic
[+]

Anti-glycative effects of asiatic acid in human keratinocyte cells.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicine (Taipei). 2014 ;4:19. Epub 2014 Aug 13. PMID: 25520932
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Advanced Glycation End products (AGE)
Pharmacological Actions : Antioxidants
[+]

Antimicrobial effect of asiatic acid against Clostridium difficile is associated with disruption of membrane permeability.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Microbiol. 2018 ;9:2125. Epub 2018 Sep 7. PMID: 30245677
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Clostridium Infections
Pharmacological Actions : Anti-Bacterial Agents
[+]

Asiatic acid ameliorates acute hepatic injury by reducing endoplasmic reticulum stress and triggering hepatocyte autophagy.Aug 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Sep ;129:110375. Epub 2020 Jun 12. PMID: 32540645
Article Published Date : Aug 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Lipopolysaccharide-Induced Toxicity, Liver Damage
Pharmacological Actions : Autophagy Up-regulation, Hepatoprotective
[+]

Asiatic acid attenuates lipopolysaccharide-induced injury by suppressing activation of the Notch signaling pathwayMar 12, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2018 Mar 13 ;9(19):15036-15046. Epub 2018 Jan 23. PMID: 29599924
Article Published Date : Mar 12, 2018
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Asiatic acid attenuates myocardial ischemia/reperfusion injury. Sep 18, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2016 Sep 19 ;21(9). Epub 2016 Sep 19. PMID: 27657024
Article Published Date : Sep 18, 2016
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Myocardial Ischemia
Pharmacological Actions : Cardioprotective
[+]

Asiatic acid could be a potential candidate for a novel treatment against osteoporosis.Feb 28, 2014

Pubmed Data : Cell Biochem Biophys. 2014 Mar ;68(2):437-42. PMID: 23934183
Article Published Date : Feb 28, 2014
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Osteoporosis
Pharmacological Actions : Osteogenic
[+]

Asiatic acid could inhibit NLRP3 inflammasome activation and has potential usage in the treatment of inflammatory bowel diseases.Jan 31, 2015

Pubmed Data : Int Immunopharmacol. 2015 Feb ;24(2):232-238. Epub 2014 Dec 15. PMID: 25523461
Article Published Date : Jan 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Colitis, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Asiatic acid enhances intratumor delivery and the antitumor effect of pegylated liposomal doxorubicin.Jun 18, 2018

Pubmed Data : Acta Pharmacol Sin. 2018 Jun 19. Epub 2018 Jun 19. PMID: 29921887
Article Published Date : Jun 18, 2018
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Colon Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Asiatic acid enhances survival of human AC16 cardiomyocytes under hypoxia by upregulating miR-1290.Dec 31, 2016

Pubmed Data : IUBMB Life. 2017 09 ;69(9):660-667. Epub 2017 Jul 7. PMID: 28686797
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Hypoxia, Myocardial Ischemia
Pharmacological Actions : Cardioprotective, MicroRNA modulator
[+]

Asiatic acid exhibits anti-inflammatory and antioxidant activities against lipopolysaccharide and d-galactosamine-induced fulminant hepatic failure.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2017 ;8:785. Epub 2017 Jul 7. PMID: 28736552
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Liver Failure: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Asiatic acid induces apoptosis and cell cycle arrest in human breast cancer cells.Mar 31, 2005

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Exp Ther. 2005 Apr ;313(1):333-44. Epub 2004 Dec 30. PMID: 15626723
Article Published Date : Mar 31, 2005
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Asiatic acid induces colon cancer cell growth inhibition and apoptosis.Jul 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2009 Aug ;32(8):1399-405. PMID: 19652380
Article Published Date : Jul 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Asiatic acid inhibits cell proliferation through regulating the expression of focal adhesion kinase in multiple myeloma cells.Nov 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2013 Dec ;6(6):1762-1766. Epub 2013 Oct 1. PMID: 24260073
Article Published Date : Nov 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Multiple Myeloma
Pharmacological Actions : Antiproliferative
[+]

Asiatic acid inhibits lactate-induced cardiomyocyte apoptosis through the regulation of the lactate signaling cascade.Nov 30, 2016

Pubmed Data : Int J Mol Med. 2016 Dec ;38(6):1823-1830. Epub 2016 Oct 20. PMID: 27779647
Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Cardiovascular Diseases
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective
[+]

Asiatic acid inhibits LPS-induced inflammatory response in endometrial epithelial cells.Feb 28, 2018

Pubmed Data : Microb Pathog. 2018 Mar ;116:195-199. Epub 2018 Jan 31. PMID: 29369796
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid, Gotu Kola
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Asiatic acid inhibits TGF-β1-induced collagen expression in human keloid fibroblasts.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Sci. 2013 ;9(10):1032-42. Epub 2013 Oct 25. PMID: 24250248
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Keloid
Pharmacological Actions : Antiproliferative
[+]

Asiatic acid interferes with the ability of breast cancer cells to invade and proliferate.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2020 ;2020:1874387. Epub 2020 Feb 10. PMID: 32104680
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative
[+]

Asiatic acid is a promising candidate for an anti-neurotoxic agent.Dec 10, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neuroinflammation. 2017 Dec 11 ;14(1):240. Epub 2017 Dec 11. PMID: 29228978
Article Published Date : Dec 10, 2017
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Brain Inflammation
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Neuroprotective Agents
Problem Substances : Amphetamine
[+]

Asiatic acid may be a valuable agent for molecular targeted therapy of human acute leukemia.Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2015 Jul ;12(1):1429-34. Epub 2015 Mar 24. PMID: 25815462
Article Published Date : Jun 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Leukemia, Promyelocytic leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Asiatic acid may be a valuable agent for the therapeutic intervention of human hepatomas.Nov 30, 2002

Pubmed Data : Cancer Lett. 2002 Dec 1 ;186(1):83-91. PMID: 12183079
Article Published Date : Nov 30, 2002
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Asiatic acid may be an effective plant-based cancer chemotherapeutic agent.Dec 09, 2019

Pubmed Data : Anticancer Agents Med Chem. 2019 Dec 10. Epub 2019 Dec 10. PMID: 31823705
Article Published Date : Dec 09, 2019
Study Type : Review
Additional Links
Substances : Asiatic Acid
Diseases : Cancers: All
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Chemotherapeutic
[+]

Asiatic acid may offer therapeutic potential for the treatment of periodontitis.Aug 31, 2017

Pubmed Data : Int Immunopharmacol. 2017 Sep ;50:313-318. Epub 2017 Jul 21. PMID: 28738247
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Lipopolysaccharide-Induced Toxicity, Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor
[+]

Asiatic acid might be a potent antibacterial agent to prevent food contamination.Jul 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicine (Taipei). 2015 Aug ;5(3):16. Epub 2015 Aug 18. PMID: 26280399
Article Published Date : Jul 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Bacillus Cereus infection, Enterococcus Infections, Escherichia coli Infections, Listeria Infections, Pseudomonas aeruginosa, Salmonella Infections, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
[+]

Asiatic acid protects against hepatic ischemia/reperfusion injury.Oct 16, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Oct 17 ;8(49):86339-86355. Epub 2017 Sep 21. PMID: 29156799
Article Published Date : Oct 16, 2017
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
[+]

Asiatic acid protects differentiated PC12 cells from Aβ25-35-induced apoptosis and tau hyperphosphorylation.Jul 10, 2018

Pubmed Data : Life Sci. 2018 Jul 11. Epub 2018 Jul 11. PMID: 30017668
Article Published Date : Jul 10, 2018
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Asiatic acid protects dopaminergic neurons from neuroinflammation.Apr 09, 2019

Pubmed Data : Biomol Ther (Seoul). 2019 Apr 10. Epub 2019 Apr 10. PMID: 30971058
Article Published Date : Apr 09, 2019
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Brain Inflammation , Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis.Mar 14, 2012

Pubmed Data : Eur J Pharmacol. 2012 Mar 15 ;679(1-3):51-9. Epub 2012 Jan 24. PMID: 22296759
Article Published Date : Mar 14, 2012
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Alzheimer's Disease, Neurodegenerative Diseases
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Asiatic acid sensitizes multidrug-resistant human lung adenocarcinoma A549/DDP cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;47(1):279-292. Epub 2018 May 11. PMID: 29768255
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Cancers: Multi-Drug Resistant, Lung Cancer
Pharmacological Actions : Chemosensitizer, Multidrug Resistance Gene Modulators
[+]

Asiatic acid, a compound found within Gotu Kola, protects against pesticide and H202-induced cytotoxicity. Apr 01, 2009

Pubmed Data : Neurochem Res. 2009 Apr;34(4):746-54. Epub 2008 Sep 19. PMID: 18802751
Article Published Date : Apr 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid, Gotu Kola
Diseases : Parkinson's Disease, Pesticide Toxicity
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Asiatic acid-induced apoptosis in human cisplatin-resistant nasopharyngeal carcinoma.Jan 24, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2020 Jan 25 ;10(2). Epub 2020 Jan 25. PMID: 31991751
Article Published Date : Jan 24, 2020
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid, Gotu Kola
Diseases : Cancers: Drug Resistant, Nasopharyngeal Cancer
Pharmacological Actions : Apoptotic
[+]

Centella asiatica promotes early differentiation, axodendritic maturation and synaptic formation in primary hippocampal neurons.Jan 10, 2021

Pubmed Data : Neurochem Int. 2021 Jan 11:104957. Epub 2021 Jan 11. PMID: 33444677
Article Published Date : Jan 10, 2021
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid, Gotu Kola
Diseases : Dementia, Memory Disorders
Pharmacological Actions : Neuroprotective Agents, Nootropic Agents
[+]

Combination of asiatic acid and naringenin modulates NK cell anti-cancer immunity.Jun 21, 2018

Pubmed Data : Mol Ther. 2018 Jun 22. Epub 2018 Jun 22. PMID: 30017880
Article Published Date : Jun 21, 2018
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid, Naringenin
Diseases : Lung Cancer, Melanoma
Pharmacological Actions : Antiproliferative , Immunomodulatory
[+]

Glioblastoma cell death was induced by asiatic acid.Oct 31, 2006

Pubmed Data : Cell Biol Toxicol. 2006 Nov ;22(6):393-408. Epub 2006 Aug 1. PMID: 16897440
Article Published Date : Oct 31, 2006
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Glioblastoma
Pharmacological Actions : Antineoplastic Agents, Apoptotic
[+]

Inhibitory effect of asiatic acid on acetylcholinesterase.Feb 14, 2012

Pubmed Data : Phytomedicine. 2012 Feb 15 ;19(3-4):311-6. Epub 2011 Nov 23. PMID: 22112723
Article Published Date : Feb 14, 2012
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Alzheimer's Disease
Pharmacological Actions : Acetylcholinesterase Inhibitor
[+]

Inhibitory effects of asiatic acid and CPT-11 on growth of HT-29 cells.Jan 31, 2005

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Invest. 2005 Feb ;52(1-2):65-73. PMID: 15751275
Article Published Date : Jan 31, 2005
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Natural compounds against doxorubicin-induced cardiotoxicity.Sep 27, 2020

Pubmed Data : Phytother Res. 2020 Sep 28. Epub 2020 Sep 28. PMID: 32985744
Article Published Date : Sep 27, 2020
Study Type : In Vitro Study
Additional Links
Substances : Alpha Linolenic Acid, Apigenin, Asiatic Acid, Ferulic acid, Genistein, Ginsenosides, Indole-3-Carbinol, Naringenin , P-Coumaric Acid, Punicalagin, Quercetin, Reishi Mushroom, Sulforaphane, Tanshinone IIA
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents, Nrf2 activation
Additional Keywords : Polysaccharides
[+]

The anti-inflammatory effects of asiatic acid in lipopolysaccharide-stimulated human corneal epithelial cells.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Ophthalmol. 2017 ;10(2):179-185. Epub 2017 Feb 18. PMID: 28251074
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Inflammation, Keratitis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The protective effect of asiatic acid against oxygen-glucose deprivation/reoxygenation injury of PC12 cells.Oct 31, 2013

Pubmed Data : Yao Xue Xue Bao. 2013 Nov ;48(11):1738-42. PMID: 24475715
Article Published Date : Oct 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Stroke
Pharmacological Actions : Anti-Apoptotic, Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

The results of this study show that asiatic acid has cytotoxic effects on glioma cell lines.May 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Cell Biochem. 2017 Jun ;430(1-2):179-190. Epub 2017 Feb 15. PMID: 28205096
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Glioblastoma, Hypoxia
Pharmacological Actions : Antiproliferative , Cell cycle arrest
[+]

The results suggest these compounds show potential for further optimization as antiviral candidates for treatment of EV71 infections.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Chem Pharm Bull (Tokyo). 2014 ;62(8):764-71. PMID: 25087628
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid, Oleanolic acid, Ursolic Acid
Diseases : Enterovirus 71
Pharmacological Actions : Antiviral Agents
[+]

These observations suggest that asiatic acid may be a potential therapeutic agent for the treatment of colon carcinoma.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Jun ;15(6):8223-8230. Epub 2018 Apr 4. PMID: 29805556
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Dose Response
[+]

These results reveal that asiatic acid enhances the stability of p21.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2014 ;15(2):963-7. PMID: 24568526
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, P21 Activation
[+]

These results showed the chemotherapeutic activities of asiatic acid against Cholangiocarcinoma.Jul 29, 2018

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2018 Jul 30 ;64(10):28-33. Epub 2018 Jul 30. PMID: 30084792
Article Published Date : Jul 29, 2018
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Cholangiocarcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic
[+]

These results suggest that asiatic acid inhibited of iNOS, COX-2, IL-6, IL-1 beta, and TNF-alpha expressions.Feb 29, 2008

Pubmed Data : Int Immunopharmacol. 2008 Mar ;8(3):431-41. Epub 2007 Dec 3. PMID: 18279797
Article Published Date : Feb 29, 2008
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results suggest that asiatic acid protects against endothelial barrier disruption.Feb 14, 2016

Pubmed Data : Phytomedicine. 2016 Feb 15 ;23(2):191-9. Epub 2016 Jan 5. PMID: 26926181
Article Published Date : Feb 14, 2016
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Endothelial Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

This study provides evidence to support the potential use of asiatic acid in the prevention of early atherosclerosis.Aug 12, 2018

Pubmed Data : Vascul Pharmacol. 2018 Aug 13. Epub 2018 Aug 13. PMID: 30114509
Article Published Date : Aug 12, 2018
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Atherosclerosis, Endothelial Dysfunction

Print Options

Some features are currently member only features. If you are already a member, please login. Otherwise, click here to become a member.

Connect with GreenMedInfo

MeWe

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.