Asiatic Acid

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2 Diseases Researched for Asiatic Acid
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2 Pharmacological Actions Researched for Asiatic Acid
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View the Evidence:
110 Abstracts with Asiatic Acid Research

[+]

Antidiabetic and antihyperlipidemic activity of asiatic acid in diabetic rats.Feb 14, 2014

Pubmed Data : Phytomedicine. 2014 Feb 15 ;21(3):225-32. Epub 2013 Sep 24. PMID: 24075211
Article Published Date : Feb 14, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Diabetes Mellitus: Type 2, Hyperlipidemia
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Natural Substances Versus Drugs
[+]

Antiobesity efficacy of asiatic acid.Feb 09, 2019

Pubmed Data : Arch Physiol Biochem. 2019 Feb 10:1-10. Epub 2019 Feb 10. PMID: 30739501
Article Published Date : Feb 09, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Obesity Agents
[+]

Asiatic acid alleviates cardiovascular remodelling in rats with L-NAME-induced hypertension.Oct 31, 2015

Pubmed Data : Clin Exp Pharmacol Physiol. 2015 Nov ;42(11):1189-97. PMID: 26234646
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents, Cardioprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Sodium Nitrate
[+]

Asiatic acid alleviates non-alcoholic fatty liver.Nov 30, 2018

Pubmed Data : Int Immunopharmacol. 2018 Dec ;65:256-267. Epub 2018 Oct 17. PMID: 30340105
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor
[+]

Asiatic acid ameliorates doxorubicin-induced cardiac and hepato-renal toxicities.Mar 31, 2018

Pubmed Data : Cardiovasc Toxicol. 2018 Apr ;18(2):131-141. PMID: 28856520
Article Published Date : Mar 31, 2018
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents, Hepatoprotective, Nrf2 activation
[+]

Asiatic acid ameliorates hepatic ischemia-reperfusion injury.Dec 31, 2017

Pubmed Data : Toxicol Appl Pharmacol. 2018 01 1 ;338:214-223. Epub 2017 Nov 28. PMID: 29196105
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation
[+]

Asiatic acid ameliorates obesity-related osteoarthritis by inhibiting myeloid differentiation protein-2.Jun 23, 2020

Pubmed Data : Food Funct. 2020 Jun 24 ;11(6):5513-5524. PMID: 32514515
Article Published Date : Jun 23, 2020
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Obesity, Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, NF-kappaB Inhibitor
[+]

Asiatic acid and maslinic acid protected heart via anti-glycative and anti-coagulatory activities in diabetic mice.Aug 31, 2015

Pubmed Data : Food Funct. 2015 Sep ;6(9):2967-74. PMID: 26190771
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Diabetes: Cardiovascular Illness
Pharmacological Actions : Cardioprotective, NF-kappaB Inhibitor
[+]

Asiatic acid and naringenin may represent as a novel and effective therapy for chronic kidney disease associated with fibrosis.Nov 09, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Nov 10 ;6(35):36984-97. PMID: 26474462
Article Published Date : Nov 09, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid, Naringenin
Diseases : Chronic Kidney Disease (CKD), Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Asiatic acid attenuates cardiac hypertrophy.Jul 31, 2014

Pubmed Data : Int J Mol Med. 2014 Aug ;34(2):499-506. Epub 2014 May 14. PMID: 24827470
Article Published Date : Jul 31, 2014
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective, Transforming growth factor beta (TGF-β) inhibitor
[+]

Asiatic acid attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells.Apr 30, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharmacol Sin. 2012 May ;33(5):578-87. Epub 2012 Mar 26. PMID: 22447225
Article Published Date : Apr 30, 2012
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Cognitive Decline/Dysfunction, Dementia, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Apoptotic, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

Asiatic acid attenuates high-fat diet-induced impaired spermatogenesis.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Mar ;15(3):2397-2403. Epub 2017 Dec 22. PMID: 29467846
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : High Fat Diet, Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Anti-Apoptotic
[+]

Asiatic acid attenuates pressure overload-induced cardiac fibrosis.Jun 25, 2019

Pubmed Data : Int Immunopharmacol. 2019 Jun 26 ;74:105712. Epub 2019 Jun 26. PMID: 31254954
Article Published Date : Jun 25, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Hypertension, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Asiatic acid attenuates renin-angiotensin system activation and improves vascular function.Apr 26, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2016 Apr 27 ;16:123. Epub 2016 Apr 27. PMID: 27121076
Article Published Date : Apr 26, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : High Fat Diet, Metabolic Syndrome X
Pharmacological Actions : Antihypertensive Agents
[+]

Asiatic acid attenuates the progression of left ventricular hypertrophy and heart failure induced by pressure overload.Nov 30, 2015

Pubmed Data : J Cardiovasc Pharmacol. 2015 Dec ;66(6):558-68. PMID: 26647013
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Cardiac Hypertrophy, Heart Failure
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-6 Downregulation
[+]

Asiatic acid can enhance spatial memory after administration for 28 days.Oct 04, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2015 Oct 5 ;7(10):8413-23. Epub 2015 Oct 5. PMID: 26445061
Article Published Date : Oct 04, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Memory Disorders
Pharmacological Actions : Antioxidants, Neurogenesis, Neuroprotective Agents
[+]

Asiatic acid could be able to modulate various pathological features of Alzheimer's disease and could hold promise in its treatment.Jan 21, 2019

Pubmed Data : Neurotox Res. 2019 Jan 22. Epub 2019 Jan 22. PMID: 30671870
Article Published Date : Jan 21, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Aluminum Toxicity , Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
Problem Substances : Aluminum Chloride
[+]

Asiatic acid could be used as an effective chemopreventive agent against 1,2-dimethylhydrazine induced colon carcinogenesis.Dec 24, 2017

Pubmed Data : Chem Biol Interact. 2017 Dec 25 ;278:197-211. Epub 2017 Nov 6. PMID: 29108773
Article Published Date : Dec 24, 2017
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Colon Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemopreventive
[+]

Asiatic acid has neuroprotective properties against 5-fluorouracil chemotherapy.Aug 08, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Aug 9 ;10(8). Epub 2018 Aug 9. PMID: 30096914
Article Published Date : Aug 08, 2018
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Chemotherapy-Induced Toxicity: 5-fluorouracil
Pharmacological Actions : Chemoprotective Agents, Neuroprotective Agents
[+]

Asiatic acid has the potential to treat inflammatory disease such as COPD.Sep 30, 2016

Pubmed Data : Int Immunopharmacol. 2016 Oct ;39:208-217. Epub 2016 Aug 3. PMID: 27494684
Article Published Date : Sep 30, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Chronic Obstructive Pulmonary Disease, Smoking
Pharmacological Actions : Superoxide Dismutase Up-regulation
[+]

Asiatic acid improved metabolic, hemodynamic abnormalities in metabolic syndrome rats.Jan 15, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2014 Jan 16 ;6(1):355-70. Epub 2014 Jan 16. PMID: 24441717
Article Published Date : Jan 15, 2014
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Inflammation, Insulin Resistance, Metabolic Syndrome X, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cellsOct 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Carcinog. 2015 Nov ;54(11):1417-29. Epub 2014 Sep 22. PMID: 25252179
Article Published Date : Oct 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Glioblastoma
Pharmacological Actions : Apoptotic
[+]

Asiatic acid inhibits lipopolysaccharide-induced acute lung injury in mice.Sep 30, 2016

Pubmed Data : Inflammation. 2016 Oct ;39(5):1642-8. PMID: 27395046
Article Published Date : Sep 30, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Asiatic acid inhibits lliver fibrosis.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(2):e31350. Epub 2012 Feb 7. PMID: 22363627
Article Published Date : Dec 31, 2011
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Liver Cirrhosis
Pharmacological Actions : Anti-Fibrotic
[+]

Asiatic acid inhibits OVX-induced osteoporosis and osteoclastogenesis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:331. Epub 2020 Mar 27. PMID: 32292339
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
[+]

Asiatic acid is a potent nutraceutical agent against the progression of Parkinson's disease.Mar 31, 2016

Pubmed Data : Food Funct. 2016 Apr ;7(4):1999-2005. PMID: 26999333
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Asiatic acid is neuroprotective in a mouse model of focal cerebral ischemia.Aug 14, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neurosci Res. 2009 Aug 15 ;87(11):2541-50. PMID: 19382233
Article Published Date : Aug 14, 2009
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Cerebral Ischemia
Pharmacological Actions : Neuroprotective Agents
[+]

Asiatic acid may be a novel candidate for development as a therapy for myocardial infarction.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Jan ;11(1):57-64. Epub 2015 Nov 17. PMID: 26889217
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Myocardial Infarction
Pharmacological Actions : Cardioprotective
[+]

Asiatic acid may be a novel therapeutic agent for cardiac hypertrophy.Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Thorac Dis. 2015 Oct ;7(10):1787-97. PMID: 26623102
Article Published Date : Sep 30, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
[+]

Asiatic acid may be a potential anti-resorptive agent for postmenopausal osteoporosis.Aug 20, 2019

Pubmed Data : Calcif Tissue Int. 2019 Aug 21. Epub 2019 Aug 21. PMID: 31435709
Article Published Date : Aug 20, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Osteoporosis, Postmenopausal Disorders
Pharmacological Actions : Osteoprotective
[+]

Asiatic acid may be a potential therapeutic agent for glaucoma.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurosci. 2018 ;12:489. Epub 2018 Jul 20. PMID: 30079010
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Glaucoma
Pharmacological Actions : Anti-Apoptotic
[+]

Asiatic acid may be a replacement alternative for chloroquine treatment with concomitant amelioration of malaria pathophysiology. Sep 12, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2016 Sep 13 ;16:357. Epub 2016 Sep 13. PMID: 27618936
Article Published Date : Sep 12, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Anemia, Malaria
Pharmacological Actions : Anti-Inflammatory Agents, Antiparasitic Agents
[+]

Asiatic acid mitigates hyperglycemia and reduces islet fibrosis in a spontaneous type 2 diabetic animal model.Jun 30, 2015

Pubmed Data : Chin J Nat Med. 2015 Jul ;13(7):529-34. PMID: 26233843
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Diabetes Mellitus: Type 2, Insulin Resistance
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Asiatic acid possesses significant anti-obesity potential.Apr 30, 2018

Pubmed Data : Mol Cell Biochem. 2018 May ;442(1-2):143-154. Epub 2017 Oct 9. PMID: 28993954
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Obesity
Pharmacological Actions : Antioxidants, Hypolipidemic, MicroRNA modulator
Additional Keywords : Anti-Obesity Agents
[+]

Asiatic acid prevents oxidative stress and apoptosis by inhibiting the translocation of α-synuclein into mitochondria.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurosci. 2018 ;12:431. Epub 2018 Jun 28. PMID: 30002614
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Parkinson's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Asiatic acid prevents the development of interstitial lung disease in a hypochlorous acid-induced mouse model of scleroderma.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Jun ;15(6):8711-8716. Epub 2018 Apr 2. PMID: 29805609
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Scleroderma
Pharmacological Actions : Antioxidants
[+]

Asiatic acid prevents the quinolinic acid-induced oxidative stress and cognitive impairment.Jan 31, 2018

Pubmed Data : Metab Brain Dis. 2018 Feb ;33(1):151-159. Epub 2017 Oct 31. PMID: 29086235
Article Published Date : Jan 31, 2018
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Cognitive Decline/Dysfunction
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Asiatic acid protects against cardiac hypertrophy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Sci. 2016 ;12(7):861-71. Epub 2016 May 25. PMID: 27313499
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Cardiac Hypertrophy, Heart Failure
Pharmacological Actions : Cardioprotective
[+]

Asiatic acid protects against cisplatin-induced acute kidney injury via anti-apoptosis and anti-inflammation.Oct 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Nov ;107:1354-1362. Epub 2018 Aug 30. PMID: 30257350
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Chemoprotective Agents
[+]

Asiatic acid protects against doxorubicin-induced cardiotoxicity.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:5347204. Epub 2020 May 15. PMID: 32509145
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Cardioprotective, Chemoprotective Agents
[+]

Asiatic acid reduces blood pressure by enhancing nitric oxide bioavailability.Sep 30, 2014

Pubmed Data : Phytother Res. 2014 Oct ;28(10):1506-12. Epub 2014 Apr 11. PMID: 24723332
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Hypertension, Oxidative Stress
Pharmacological Actions : Antihypertensive Agents, Malondialdehyde Down-regulation, Nitric Oxide Enhancer
[+]

Combination of carnosine and asiatic acid provided greater anti-inflammatory protection for HUVE cells and diabetic mice.Feb 21, 2019

Pubmed Data : Food Chem Toxicol. 2019 Feb 22. Epub 2019 Feb 22. PMID: 30802477
Article Published Date : Feb 21, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid, Carnosine
Diseases : Diabetic Complications, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substance Synergy
[+]

Effect and mechanism of asiatic acid on autophagy in myocardial ischemia-reperfusion injury in vivo and in vitro.Oct 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2020 Nov ;20(5):54. Epub 2020 Sep 4. PMID: 32952644
Article Published Date : Oct 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Myocardial Ischemia
Pharmacological Actions : Autophagy Inhibitors, Cardioprotective
[+]

Evaluation of the anxiolytic and antidepressant effects of asiatic acid.Mar 31, 2015

Pubmed Data : AANA J. 2015 Apr ;83(2):91-8. PMID: 26016167
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid, Gotu Kola
Diseases : Anxiety Disorders, Depression
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
Additional Keywords : Phytotherapy
[+]

Mechanism underlying mitochondrial protection of asiatic acid against hepatotoxicity in mice.Jan 31, 2006

Pubmed Data : J Pharm Pharmacol. 2006 Feb ;58(2):227-33. PMID: 16451751
Article Published Date : Jan 31, 2006
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Lipopolysaccharide-Induced Toxicity, Liver Damage
Pharmacological Actions : Hepatoprotective
[+]

Neuroprotective effect of asiatic acid against spinal cord injury in rats.Jul 14, 2016

Pubmed Data : Life Sci. 2016 Jul 15 ;157:45-51. Epub 2016 May 3. PMID: 27153777
Article Published Date : Jul 14, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Neuroprotective effect of asiatic acid in rat model of focal embolic stroke.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2014 ;37(8):1397-401. PMID: 25087961
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions : Neuroprotective Agents
[+]

Protective effect of asiatic acid from Potentilla chinensis on alcohol hepatic injury.Jun 30, 2015

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2015 Jul ;40(14):2866-70. PMID: 26666041
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Protective effect of asiatic acid in an experimental cerulein-induced model of acute pancreatitis in miceDec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2017 ;9(8):3842-3852. Epub 2017 Aug 15. PMID: 28861174
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Pancreatitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Protective effects of asiatic acid against pelvic inflammatory disease in rats.May 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2019 Jun ;17(6):4687-4692. Epub 2019 Apr 17. PMID: 31086602
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Pelvic Inflammatory Disease
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Protective effects of asiatic acid in a spontaneous type 2 diabetic mouse model.Jul 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2017 Aug ;16(2):1333-1339. Epub 2017 Jun 2. PMID: 28586016
Article Published Date : Jul 31, 2017
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents, MicroRNA modulator
[+]

The use of asiatic acid may be a potential efficient therapeutic strategy for the treatment of spinal cord injury-induced acute lung injury.Nov 30, 2016

Pubmed Data : Inflammation. 2016 Dec ;39(6):1853-1861. PMID: 27605220
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Inflammation, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation
[+]

There is an excellent prospect of using asiatic acid to treat diabetic nephropathy.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2018 ;10(11):3733-3741. Epub 2018 Nov 15. PMID: 30662623
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Diabetic Nephropathy
Pharmacological Actions : Renoprotective
[+]

These findings demonstrated that asiatic acid exerts beneficial effects on myocardial ischemia/reperfusion injury.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2018 ;12:3573-3582. Epub 2018 Oct 25. PMID: 30498333
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

These findings indicate that asiatic acid is an antihypertensive agent that ameliorates hemodynamic alterations in 2K-1C hypertensive rats.Sep 30, 2017

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2017 Oct ;390(10):1073-1083. Epub 2017 Jul 21. PMID: 28733880
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Hypertension
Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Antioxidants, NF-kappaB Inhibitor
[+]

These findings indicated that the supplement of asiatic acid might be beneficial to the prevention or alleviation of brain aging.Jan 31, 2015

Pubmed Data : Food Funct. 2015 Feb ;6(2):542-8. PMID: 25504333
Article Published Date : Jan 31, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Aging, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These findings suggest that asiatic acid prevents the progression of liver fibrosis.Jun 30, 2018

Pubmed Data : Int Immunopharmacol. 2018 Jul ;60:1-8. Epub 2018 Apr 24. PMID: 29702278
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

These results demonstrate that asiatic acid ameliorates carbon tetrachloride-induced liver fibrosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2018 ;12:3595-3605. Epub 2018 Oct 26. PMID: 30464391
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, NF-kappaB Inhibitor, Nrf2 activation
[+]

These results provide new insight into the anti-fibrotic mechanism of asiatic acid.Nov 07, 2019

Pubmed Data : Acta Pharmacol Sin. 2019 Nov 8. Epub 2019 Nov 8. PMID: 31705123
Article Published Date : Nov 07, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

These results suggest that asiatic acid is a potent hepatic protective agent against high-fat diet-induced hepatic injury.May 20, 2014

Pubmed Data : J Agric Food Chem. 2014 May 21 ;62(20):4625-31. Epub 2014 May 6. PMID: 24779966
Article Published Date : May 20, 2014
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Fatty Liver, Insulin Resistance, Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

This study concluded that asiatic acid can protect against renal dysfunction.Jan 30, 2020

Pubmed Data : Cardiovasc Hematol Agents Med Chem. 2020 Jan 31. Epub 2020 Jan 31. PMID: 32003703
Article Published Date : Jan 30, 2020
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Diabetic Nephropathy
Pharmacological Actions : Renoprotective
[+]

This study shows asiatic acid is effective against multiple models of focal ischemia.May 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Stroke. 2012 Jun ;43(6):1632-8. Epub 2012 Apr 17. PMID: 22511009
Article Published Date : May 31, 2012
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Stroke
Pharmacological Actions : Matrix metalloproteinase-9 (MMP-9) inhibitor, Neuroprotective Agents
[+]

A pharmacological review on asiatic acid and its derivatives.Mar 31, 2018

Pubmed Data : SLAS Technol. 2018 Apr ;23(2):111-127. Epub 2018 Jan 23. PMID: 29361877
Article Published Date : Mar 31, 2018
Study Type : Review
Additional Links
Substances : Asiatic Acid, Gotu Kola
Diseases : Chronic Disease
[+]

Anti-glioma activity and the mechanism of cellular uptake of asiatic acid-loaded solid lipid nanoparticles.Mar 15, 2016

Pubmed Data : Int J Pharm. 2016 Mar 16 ;500(1-2):305-15. Epub 2016 Jan 13. PMID: 26775062
Article Published Date : Mar 15, 2016
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Glioma
Pharmacological Actions : Antineoplastic Agents, Apoptotic
[+]

Anti-glycative effects of asiatic acid in human keratinocyte cells.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicine (Taipei). 2014 ;4:19. Epub 2014 Aug 13. PMID: 25520932
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Advanced Glycation End products (AGE)
Pharmacological Actions : Antioxidants
[+]

Antimicrobial effect of asiatic acid against Clostridium difficile is associated with disruption of membrane permeability.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Microbiol. 2018 ;9:2125. Epub 2018 Sep 7. PMID: 30245677
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Clostridium Infections
Pharmacological Actions : Anti-Bacterial Agents
[+]

Asiatic acid ameliorates acute hepatic injury by reducing endoplasmic reticulum stress and triggering hepatocyte autophagy.Aug 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Sep ;129:110375. Epub 2020 Jun 12. PMID: 32540645
Article Published Date : Aug 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Lipopolysaccharide-Induced Toxicity, Liver Damage
Pharmacological Actions : Autophagy Up-regulation, Hepatoprotective
[+]

Asiatic acid attenuates lipopolysaccharide-induced injury by suppressing activation of the Notch signaling pathwayMar 12, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2018 Mar 13 ;9(19):15036-15046. Epub 2018 Jan 23. PMID: 29599924
Article Published Date : Mar 12, 2018
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Asiatic acid attenuates myocardial ischemia/reperfusion injury. Sep 18, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2016 Sep 19 ;21(9). Epub 2016 Sep 19. PMID: 27657024
Article Published Date : Sep 18, 2016
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Myocardial Ischemia
Pharmacological Actions : Cardioprotective
[+]

Asiatic acid could be a potential candidate for a novel treatment against osteoporosis.Feb 28, 2014

Pubmed Data : Cell Biochem Biophys. 2014 Mar ;68(2):437-42. PMID: 23934183
Article Published Date : Feb 28, 2014
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Osteoporosis
Pharmacological Actions : Osteogenic
[+]

Asiatic acid could inhibit NLRP3 inflammasome activation and has potential usage in the treatment of inflammatory bowel diseases.Jan 31, 2015

Pubmed Data : Int Immunopharmacol. 2015 Feb ;24(2):232-238. Epub 2014 Dec 15. PMID: 25523461
Article Published Date : Jan 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Colitis, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Asiatic acid enhances intratumor delivery and the antitumor effect of pegylated liposomal doxorubicin.Jun 18, 2018

Pubmed Data : Acta Pharmacol Sin. 2018 Jun 19. Epub 2018 Jun 19. PMID: 29921887
Article Published Date : Jun 18, 2018
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Colon Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Asiatic acid enhances survival of human AC16 cardiomyocytes under hypoxia by upregulating miR-1290.Dec 31, 2016

Pubmed Data : IUBMB Life. 2017 09 ;69(9):660-667. Epub 2017 Jul 7. PMID: 28686797
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Hypoxia, Myocardial Ischemia
Pharmacological Actions : Cardioprotective, MicroRNA modulator
[+]

Asiatic acid exhibits anti-inflammatory and antioxidant activities against lipopolysaccharide and d-galactosamine-induced fulminant hepatic failure.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2017 ;8:785. Epub 2017 Jul 7. PMID: 28736552
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Liver Failure: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Asiatic acid induces apoptosis and cell cycle arrest in human breast cancer cells.Mar 31, 2005

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Exp Ther. 2005 Apr ;313(1):333-44. Epub 2004 Dec 30. PMID: 15626723
Article Published Date : Mar 31, 2005
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Asiatic acid induces colon cancer cell growth inhibition and apoptosis.Jul 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2009 Aug ;32(8):1399-405. PMID: 19652380
Article Published Date : Jul 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Asiatic acid inhibits cell proliferation through regulating the expression of focal adhesion kinase in multiple myeloma cells.Nov 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2013 Dec ;6(6):1762-1766. Epub 2013 Oct 1. PMID: 24260073
Article Published Date : Nov 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Multiple Myeloma
Pharmacological Actions : Antiproliferative
[+]

Asiatic acid inhibits lactate-induced cardiomyocyte apoptosis through the regulation of the lactate signaling cascade.Nov 30, 2016

Pubmed Data : Int J Mol Med. 2016 Dec ;38(6):1823-1830. Epub 2016 Oct 20. PMID: 27779647
Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Cardiovascular Diseases
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective
[+]

Asiatic acid inhibits LPS-induced inflammatory response in endometrial epithelial cells.Feb 28, 2018

Pubmed Data : Microb Pathog. 2018 Mar ;116:195-199. Epub 2018 Jan 31. PMID: 29369796
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid, Gotu Kola
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Asiatic acid inhibits TGF-β1-induced collagen expression in human keloid fibroblasts.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Sci. 2013 ;9(10):1032-42. Epub 2013 Oct 25. PMID: 24250248
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Keloid
Pharmacological Actions : Antiproliferative
[+]

Asiatic acid interferes with the ability of breast cancer cells to invade and proliferate.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2020 ;2020:1874387. Epub 2020 Feb 10. PMID: 32104680
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative
[+]

Asiatic acid is a promising candidate for an anti-neurotoxic agent.Dec 10, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neuroinflammation. 2017 Dec 11 ;14(1):240. Epub 2017 Dec 11. PMID: 29228978
Article Published Date : Dec 10, 2017
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Brain Inflammation
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Neuroprotective Agents
Problem Substances : Amphetamine
[+]

Asiatic acid may be a valuable agent for molecular targeted therapy of human acute leukemia.Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2015 Jul ;12(1):1429-34. Epub 2015 Mar 24. PMID: 25815462
Article Published Date : Jun 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Leukemia, Promyelocytic leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Asiatic acid may be a valuable agent for the therapeutic intervention of human hepatomas.Nov 30, 2002

Pubmed Data : Cancer Lett. 2002 Dec 1 ;186(1):83-91. PMID: 12183079
Article Published Date : Nov 30, 2002
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Asiatic acid may be an effective plant-based cancer chemotherapeutic agent.Dec 09, 2019

Pubmed Data : Anticancer Agents Med Chem. 2019 Dec 10. Epub 2019 Dec 10. PMID: 31823705
Article Published Date : Dec 09, 2019
Study Type : Review
Additional Links
Substances : Asiatic Acid
Diseases : Cancers: All
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Chemotherapeutic
[+]

Asiatic acid may offer therapeutic potential for the treatment of periodontitis.Aug 31, 2017

Pubmed Data : Int Immunopharmacol. 2017 Sep ;50:313-318. Epub 2017 Jul 21. PMID: 28738247
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Lipopolysaccharide-Induced Toxicity, Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor
[+]

Asiatic acid might be a potent antibacterial agent to prevent food contamination.Jul 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicine (Taipei). 2015 Aug ;5(3):16. Epub 2015 Aug 18. PMID: 26280399
Article Published Date : Jul 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Bacillus Cereus infection, Enterococcus Infections, Escherichia coli Infections, Listeria Infections, Pseudomonas aeruginosa, Salmonella Infections, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
[+]

Asiatic acid protects against hepatic ischemia/reperfusion injury.Oct 16, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Oct 17 ;8(49):86339-86355. Epub 2017 Sep 21. PMID: 29156799
Article Published Date : Oct 16, 2017
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
[+]

Asiatic acid protects differentiated PC12 cells from Aβ25-35-induced apoptosis and tau hyperphosphorylation.Jul 10, 2018

Pubmed Data : Life Sci. 2018 Jul 11. Epub 2018 Jul 11. PMID: 30017668
Article Published Date : Jul 10, 2018
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Asiatic acid protects dopaminergic neurons from neuroinflammation.Apr 09, 2019

Pubmed Data : Biomol Ther (Seoul). 2019 Apr 10. Epub 2019 Apr 10. PMID: 30971058
Article Published Date : Apr 09, 2019
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Brain Inflammation , Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis.Mar 14, 2012

Pubmed Data : Eur J Pharmacol. 2012 Mar 15 ;679(1-3):51-9. Epub 2012 Jan 24. PMID: 22296759
Article Published Date : Mar 14, 2012
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Alzheimer's Disease, Neurodegenerative Diseases
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Asiatic acid sensitizes multidrug-resistant human lung adenocarcinoma A549/DDP cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;47(1):279-292. Epub 2018 May 11. PMID: 29768255
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Cancers: Multi-Drug Resistant, Lung Cancer
Pharmacological Actions : Chemosensitizer, Multidrug Resistance Gene Modulators
[+]

Asiatic acid, a compound found within Gotu Kola, protects against pesticide and H202-induced cytotoxicity. Apr 01, 2009

Pubmed Data : Neurochem Res. 2009 Apr;34(4):746-54. Epub 2008 Sep 19. PMID: 18802751
Article Published Date : Apr 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid, Gotu Kola
Diseases : Parkinson's Disease, Pesticide Toxicity
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Asiatic acid-induced apoptosis in human cisplatin-resistant nasopharyngeal carcinoma.Jan 24, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2020 Jan 25 ;10(2). Epub 2020 Jan 25. PMID: 31991751
Article Published Date : Jan 24, 2020
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid, Gotu Kola
Diseases : Cancers: Drug Resistant, Nasopharyngeal Cancer
Pharmacological Actions : Apoptotic
[+]

Centella asiatica promotes early differentiation, axodendritic maturation and synaptic formation in primary hippocampal neurons.Jan 10, 2021

Pubmed Data : Neurochem Int. 2021 Jan 11:104957. Epub 2021 Jan 11. PMID: 33444677
Article Published Date : Jan 10, 2021
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid, Gotu Kola
Diseases : Dementia, Memory Disorders
Pharmacological Actions : Neuroprotective Agents, Nootropic Agents
[+]

Combination of asiatic acid and naringenin modulates NK cell anti-cancer immunity.Jun 21, 2018

Pubmed Data : Mol Ther. 2018 Jun 22. Epub 2018 Jun 22. PMID: 30017880
Article Published Date : Jun 21, 2018
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid, Naringenin
Diseases : Lung Cancer, Melanoma
Pharmacological Actions : Antiproliferative , Immunomodulatory
[+]

Glioblastoma cell death was induced by asiatic acid.Oct 31, 2006

Pubmed Data : Cell Biol Toxicol. 2006 Nov ;22(6):393-408. Epub 2006 Aug 1. PMID: 16897440
Article Published Date : Oct 31, 2006
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Glioblastoma
Pharmacological Actions : Antineoplastic Agents, Apoptotic
[+]

Inhibitory effect of asiatic acid on acetylcholinesterase.Feb 14, 2012

Pubmed Data : Phytomedicine. 2012 Feb 15 ;19(3-4):311-6. Epub 2011 Nov 23. PMID: 22112723
Article Published Date : Feb 14, 2012
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Alzheimer's Disease
Pharmacological Actions : Acetylcholinesterase Inhibitor
[+]

Inhibitory effects of asiatic acid and CPT-11 on growth of HT-29 cells.Jan 31, 2005

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Invest. 2005 Feb ;52(1-2):65-73. PMID: 15751275
Article Published Date : Jan 31, 2005
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Natural compounds against doxorubicin-induced cardiotoxicity.Sep 27, 2020

Pubmed Data : Phytother Res. 2020 Sep 28. Epub 2020 Sep 28. PMID: 32985744
Article Published Date : Sep 27, 2020
Study Type : In Vitro Study
Additional Links
Substances : Alpha Linolenic Acid, Apigenin, Asiatic Acid, Ferulic acid, Genistein, Ginsenosides, Indole-3-Carbinol, Naringenin , P-Coumaric Acid, Punicalagin, Quercetin, Reishi Mushroom, Sulforaphane, Tanshinone IIA
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents, Nrf2 activation
Additional Keywords : Polysaccharides
[+]

The anti-inflammatory effects of asiatic acid in lipopolysaccharide-stimulated human corneal epithelial cells.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Ophthalmol. 2017 ;10(2):179-185. Epub 2017 Feb 18. PMID: 28251074
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Inflammation, Keratitis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The protective effect of asiatic acid against oxygen-glucose deprivation/reoxygenation injury of PC12 cells.Oct 31, 2013

Pubmed Data : Yao Xue Xue Bao. 2013 Nov ;48(11):1738-42. PMID: 24475715
Article Published Date : Oct 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Stroke
Pharmacological Actions : Anti-Apoptotic, Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

The results of this study show that asiatic acid has cytotoxic effects on glioma cell lines.May 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Cell Biochem. 2017 Jun ;430(1-2):179-190. Epub 2017 Feb 15. PMID: 28205096
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Glioblastoma, Hypoxia
Pharmacological Actions : Antiproliferative , Cell cycle arrest
[+]

The results suggest these compounds show potential for further optimization as antiviral candidates for treatment of EV71 infections.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Chem Pharm Bull (Tokyo). 2014 ;62(8):764-71. PMID: 25087628
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid, Oleanolic acid, Ursolic Acid
Diseases : Enterovirus 71
Pharmacological Actions : Antiviral Agents
[+]

These observations suggest that asiatic acid may be a potential therapeutic agent for the treatment of colon carcinoma.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Jun ;15(6):8223-8230. Epub 2018 Apr 4. PMID: 29805556
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Dose Response
[+]

These results reveal that asiatic acid enhances the stability of p21.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2014 ;15(2):963-7. PMID: 24568526
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, P21 Activation
[+]

These results showed the chemotherapeutic activities of asiatic acid against Cholangiocarcinoma.Jul 29, 2018

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2018 Jul 30 ;64(10):28-33. Epub 2018 Jul 30. PMID: 30084792
Article Published Date : Jul 29, 2018
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Cholangiocarcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic
[+]

These results suggest that asiatic acid inhibited of iNOS, COX-2, IL-6, IL-1 beta, and TNF-alpha expressions.Feb 29, 2008

Pubmed Data : Int Immunopharmacol. 2008 Mar ;8(3):431-41. Epub 2007 Dec 3. PMID: 18279797
Article Published Date : Feb 29, 2008
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results suggest that asiatic acid protects against endothelial barrier disruption.Feb 14, 2016

Pubmed Data : Phytomedicine. 2016 Feb 15 ;23(2):191-9. Epub 2016 Jan 5. PMID: 26926181
Article Published Date : Feb 14, 2016
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Endothelial Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

This study provides evidence to support the potential use of asiatic acid in the prevention of early atherosclerosis.Aug 12, 2018

Pubmed Data : Vascul Pharmacol. 2018 Aug 13. Epub 2018 Aug 13. PMID: 30114509
Article Published Date : Aug 12, 2018
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Atherosclerosis, Endothelial Dysfunction

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