Asiatic Acid

Name	AC	CK
Inflammation	7	10
Lipopolysaccharide-Induced Toxicity	8	10
Oxidative Stress	5	10
Cardiac Hypertrophy	4	8
Hypertension	4	8
Cognitive Decline/Dysfunction	3	6
Colon Cancer	5	6
Diabetes Mellitus: Type 2	3	6
Insulin Resistance	3	6
Myocardial Ischemia	4	6
Obesity	3	6
Parkinson's Disease	4	6
Alzheimer's Disease	4	5
Chemotherapy-Induced Toxicity: Doxorubicin	3	5
Liver Damage	3	5
Osteoporosis	3	5
Chemically-Induced Liver Damage	2	4
Diabetic Nephropathy	2	4
Glioblastoma	3	4
Heart Failure	2	4
High Fat Diet	2	4
Kidney Fibrosis	2	4
Liver Fibrosis	2	4
Metabolic Syndrome X	2	4
Spinal Cord Injuries	2	4
Dementia	2	3
Glioma	2	3
Liver Injury: Ischemia/reperfusion	2	3
Lung Cancer	3	3
Memory Disorders	2	3
Stroke	2	3
Aging	1	2
Alcoholic Liver Disease	1	2
Aluminum Toxicity	1	2
Anemia	1	2
Anxiety Disorders	1	2
Brain Inflammation	2	2
Breast Cancer	2	2
Cerebral Ischemia	1	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Chronic Kidney Disease (CKD)	1	2
Chronic Obstructive Pulmonary Disease	1	2
Depression	1	2
Diabetes: Cardiovascular Illness	1	2
Diabetic Complications	1	2
Endothelial Dysfunction	2	2
Epilepsy	1	2
Fatty Liver	1	2
Glaucoma	1	2
Hyperlipidemia	1	2
Hypoxia	2	2
Lipid Peroxidation	1	2
Liver Cancer	2	2
Liver Cirrhosis	1	2
Malaria	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Myocardial Fibrosis	1	2
Myocardial Infarction	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Osteoarthritis	1	2
Pancreatitis	1	2
Pelvic Inflammatory Disease	1	2
Postmenopausal Disorders	1	2
Scleroderma	1	2
Smoking	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Advanced Glycation End products (AGE)	1	1
Atherosclerosis	1	1
Bacillus Cereus infection	1	1
Cancers: All	1	1
Cancers: Drug Resistant	1	1
Cancers: Multi-Drug Resistant	1	1
Candida Albicans	1	1
Cardiovascular Diseases	1	1
Cholangiocarcinoma	1	1
Chronic Disease	1	1
Clostridium Infections	1	1
Colitis	1	1
Enterococcus Infections	1	1
Enterovirus 71	1	1
Escherichia coli Infections	1	1
Inflammatory Bowel Diseases	1	1
Keloid	1	1
Keratitis	1	1
Leukemia	1	1
Listeria Infections	1	1
Liver Failure: Acute	1	1
Melanoma	1	1
Multiple Myeloma	1	1
Nasopharyngeal Cancer	1	1
Neurodegenerative Diseases	1	1
Periodontitis	1	1
Pesticide Toxicity	1	1
Promyelocytic leukemia	1	1
Pseudomonas aeruginosa	1	1
Salmonella Infections	1	1
Staphylococcus aureus infection	1	1

Name	AC	CK
Anti-Inflammatory Agents	29	47
Antioxidants	18	31
Neuroprotective Agents	19	31
Cardioprotective	16	28
NF-kappaB Inhibitor	13	23
Tumor Necrosis Factor (TNF) Alpha Inhibitor	14	23
Anti-Apoptotic	12	19
Apoptotic	15	18
Antiproliferative	15	17
Interleukin-6 Downregulation	11	17
Hepatoprotective	9	16
Interleukin-1 beta downregulation	9	13
Anti-Fibrotic	6	12
Chemoprotective Agents	5	9
Nrf2 activation	5	9
Antihypertensive Agents	4	8
Renoprotective	4	8
Malondialdehyde Down-regulation	4	7
Hypoglycemic Agents	3	6
MicroRNA modulator	3	5
Superoxide Dismutase Up-regulation	3	5
Osteoprotective	2	4
Anti-Bacterial Agents	3	3
Antineoplastic Agents	3	3
Bcl-2 protein down-regulation	2	3
Cell cycle arrest	3	3
Chemotherapeutic	3	3
Cyclooxygenase 2 Inhibitors	2	3
Transforming growth factor beta (TGF-β) inhibitor	2	3
Anti-Anxiety Agents	1	2
Anticarcinogenic Agents	1	2
Anticonvulsants	1	2
Antidepressive Agents	1	2
Antiparasitic Agents	1	2
Autophagy Inhibitors	1	2
Chemopreventive	1	2
Chondroprotective	1	2
Heme oxygenase-1 up-regulation	1	2
Hypolipidemic	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	2
Neurogenesis	1	2
Nitric Oxide Enhancer	1	2
Postaglandin PGE2 downregulation	2	2
Acetylcholinesterase Inhibitor	1	1
Angiogenesis Inhibitors	1	1
Anti-metastatic	1	1
Antiviral Agents	1	1
Autophagy Up-regulation	1	1
Chemosensitizer	1	1
Immunomodulatory	1	1
Interferon Gamma Reducer	1	1
Interleukin-8 downregulation	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Multidrug Resistance Gene Modulators	1	1
Nootropic Agents	1	1
Osteogenic	1	1
P21 Activation	1	1
Tumor Suppressor Protein p53 Upregulation	1	1

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Pubmed Data : Exp Ther Med. 2016 Jan ;11(1):57-64. Epub 2015 Nov 17. PMID: 26889217

Article Published Date : Dec 31, 2015

Study Type : Animal Study

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Substances : Asiatic Acid

Diseases : Myocardial Infarction

Pharmacological Actions : Cardioprotective

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Asiatic acid may be a novel therapeutic agent for cardiac hypertrophy.Sep 30, 2015

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Pubmed Data : J Thorac Dis. 2015 Oct ;7(10):1787-97. PMID: 26623102

Article Published Date : Sep 30, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Asiatic Acid

Diseases : Cardiac Hypertrophy

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 beta downregulation, NF-kappaB Inhibitor

[+]

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Pubmed Data : Metab Brain Dis. 2018 Feb ;33(1):151-159. Epub 2017 Oct 31. PMID: 29086235

Article Published Date : Jan 31, 2018

Study Type : Animal Study

Additional Links

Substances : Asiatic Acid

Diseases : Cognitive Decline/Dysfunction

Pharmacological Actions : Antioxidants, Neuroprotective Agents

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Asiatic acid protects against cardiac hypertrophy.Dec 31, 2015

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Antifungal activity and potential mechanism of Asiatic acid alone and in combination with fluconazole against Candida albicans.Apr 09, 2021

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Asiatic acid interferes with the ability of breast cancer cells to invade and proliferate.Dec 31, 2019

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Pubmed Data : Biomed Res Int. 2020 ;2020:1874387. Epub 2020 Feb 10. PMID: 32104680

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

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Substances : Asiatic Acid

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative

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Asiatic acid is a promising candidate for an anti-neurotoxic agent.Dec 10, 2017

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Pubmed Data : J Neuroinflammation. 2017 Dec 11 ;14(1):240. Epub 2017 Dec 11. PMID: 29228978

Article Published Date : Dec 10, 2017

Study Type : In Vitro Study

Additional Links

Substances : Asiatic Acid

Diseases : Brain Inflammation

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Neuroprotective Agents

Problem Substances : Amphetamine

[+]

Asiatic acid may be a valuable agent for molecular targeted therapy of human acute leukemia.Jun 30, 2015

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Pubmed Data : Neurochem Res. 2009 Apr;34(4):746-54. Epub 2008 Sep 19. PMID: 18802751

Article Published Date : Apr 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Asiatic Acid, Gotu Kola

Diseases : Parkinson's Disease, Pesticide Toxicity

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

Asiatic acid-induced apoptosis in human cisplatin-resistant nasopharyngeal carcinoma.Jan 24, 2020

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Pubmed Data : Chem Pharm Bull (Tokyo). 2014 ;62(8):764-71. PMID: 25087628

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Asiatic Acid, Oleanolic acid, Ursolic Acid

Diseases : Enterovirus 71

Pharmacological Actions : Antiviral Agents

[+]

These observations suggest that asiatic acid may be a potential therapeutic agent for the treatment of colon carcinoma.May 31, 2018

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Pubmed Data : Oncol Lett. 2018 Jun ;15(6):8223-8230. Epub 2018 Apr 4. PMID: 29805556

Article Published Date : May 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Asiatic Acid

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Dose Response

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These results reveal that asiatic acid enhances the stability of p21.Dec 31, 2013

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View the Evidence: 114 Abstracts with Asiatic Acid Research

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Antidiabetic and antihyperlipidemic activity of asiatic acid in diabetic rats.Feb 14, 2014

Antiobesity efficacy of asiatic acid.Feb 09, 2019

Asiatic acid alleviates cardiovascular remodelling in rats with L-NAME-induced hypertension.Oct 31, 2015

Asiatic acid alleviates non-alcoholic fatty liver.Nov 30, 2018

Asiatic acid ameliorates doxorubicin-induced cardiac and hepato-renal toxicities.Mar 31, 2018

Asiatic acid ameliorates hepatic ischemia-reperfusion injury.Dec 31, 2017

Asiatic acid ameliorates obesity-related osteoarthritis by inhibiting myeloid differentiation protein-2.Jun 23, 2020

Asiatic acid and maslinic acid protected heart via anti-glycative and anti-coagulatory activities in diabetic mice.Aug 31, 2015

Asiatic acid and naringenin may represent as a novel and effective therapy for chronic kidney disease associated with fibrosis.Nov 09, 2015

Asiatic acid attenuates cardiac hypertrophy.Jul 31, 2014

Asiatic acid attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells.Apr 30, 2012

Asiatic acid attenuates high-fat diet-induced impaired spermatogenesis.Feb 28, 2018

Asiatic acid attenuates pressure overload-induced cardiac fibrosis.Jun 25, 2019

Asiatic acid attenuates renin-angiotensin system activation and improves vascular function.Apr 26, 2016

Asiatic acid attenuates the progression of left ventricular hypertrophy and heart failure induced by pressure overload.Nov 30, 2015

Asiatic acid can enhance spatial memory after administration for 28 days.Oct 04, 2015

Asiatic acid can prevent seizures and improve cognitive impairment.Mar 09, 2021

Asiatic acid could be able to modulate various pathological features of Alzheimer's disease and could hold promise in its treatment.Jan 21, 2019

Asiatic acid could be used as an effective chemopreventive agent against 1,2-dimethylhydrazine induced colon carcinogenesis.Dec 24, 2017

Asiatic acid has neuroprotective properties against 5-fluorouracil chemotherapy.Aug 08, 2018

Asiatic acid has the potential to treat inflammatory disease such as COPD.Sep 30, 2016

Asiatic acid improved metabolic, hemodynamic abnormalities in metabolic syndrome rats.Jan 15, 2014

Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cellsOct 31, 2015

Asiatic acid inhibits lipopolysaccharide-induced acute lung injury in mice.Sep 30, 2016

Asiatic acid inhibits lliver fibrosis.Dec 31, 2011

Asiatic acid inhibits OVX-induced osteoporosis and osteoclastogenesis.Dec 31, 2019

Asiatic acid is a potent nutraceutical agent against the progression of Parkinson's disease.Mar 31, 2016

Asiatic acid is neuroprotective in a mouse model of focal cerebral ischemia.Aug 14, 2009

Asiatic acid may be a novel candidate for development as a therapy for myocardial infarction.Dec 31, 2015

Asiatic acid may be a novel therapeutic agent for cardiac hypertrophy.Sep 30, 2015

Asiatic acid may be a potential anti-resorptive agent for postmenopausal osteoporosis.Aug 20, 2019

Asiatic acid may be a potential therapeutic agent for glaucoma.Dec 31, 2017

Asiatic acid may be a replacement alternative for chloroquine treatment with concomitant amelioration of malaria pathophysiology. Sep 12, 2016

Asiatic acid mitigates hyperglycemia and reduces islet fibrosis in a spontaneous type 2 diabetic animal model.Jun 30, 2015

Asiatic acid possesses significant anti-obesity potential.Apr 30, 2018

Asiatic acid prevents oxidative stress and apoptosis by inhibiting the translocation of α-synuclein into mitochondria.Dec 31, 2017

Asiatic acid prevents the development of interstitial lung disease in a hypochlorous acid-induced mouse model of scleroderma.May 31, 2018

Asiatic acid prevents the quinolinic acid-induced oxidative stress and cognitive impairment.Jan 31, 2018

Asiatic acid protects against cardiac hypertrophy.Dec 31, 2015

Asiatic acid protects against cisplatin-induced acute kidney injury via anti-apoptosis and anti-inflammation.Oct 31, 2018

Asiatic acid protects against doxorubicin-induced cardiotoxicity.Dec 31, 2019

Asiatic acid reduces blood pressure by enhancing nitric oxide bioavailability.Sep 30, 2014

Combination of carnosine and asiatic acid provided greater anti-inflammatory protection for HUVE cells and diabetic mice.Feb 21, 2019

Effect and mechanism of asiatic acid on autophagy in myocardial ischemia-reperfusion injury in vivo and in vitro.Oct 31, 2020

Evaluation of the anxiolytic and antidepressant effects of asiatic acid.Mar 31, 2015

Influence of asiatic acid on cell proliferation and DNA damage in vitro and in vivo systems.Mar 31, 2021

Mechanism underlying mitochondrial protection of asiatic acid against hepatotoxicity in mice.Jan 31, 2006

Neuroprotective effect of asiatic acid against spinal cord injury in rats.Jul 14, 2016

Neuroprotective effect of asiatic acid in rat model of focal embolic stroke.Dec 31, 2013

Protective effect of asiatic acid from Potentilla chinensis on alcohol hepatic injury.Jun 30, 2015

Protective effect of asiatic acid in an experimental cerulein-induced model of acute pancreatitis in miceDec 31, 2016

Protective effects of asiatic acid against pelvic inflammatory disease in rats.May 31, 2019

Protective effects of asiatic acid in a spontaneous type 2 diabetic mouse model.Jul 31, 2017

The use of asiatic acid may be a potential efficient therapeutic strategy for the treatment of spinal cord injury-induced acute lung injury.Nov 30, 2016

There is an excellent prospect of using asiatic acid to treat diabetic nephropathy.Dec 31, 2017

These findings demonstrated that asiatic acid exerts beneficial effects on myocardial ischemia/reperfusion injury.Dec 31, 2017

These findings indicate that asiatic acid is an antihypertensive agent that ameliorates hemodynamic alterations in 2K-1C hypertensive rats.Sep 30, 2017

These findings indicated that the supplement of asiatic acid might be beneficial to the prevention or alleviation of brain aging.Jan 31, 2015

These findings suggest that asiatic acid prevents the progression of liver fibrosis.Jun 30, 2018

These results demonstrate that asiatic acid ameliorates carbon tetrachloride-induced liver fibrosis.Dec 31, 2017

These results provide new insight into the anti-fibrotic mechanism of asiatic acid.Nov 07, 2019

These results suggest that asiatic acid is a potent hepatic protective agent against high-fat diet-induced hepatic injury.May 20, 2014

This study concluded that asiatic acid can protect against renal dysfunction.Jan 30, 2020

This study shows asiatic acid is effective against multiple models of focal ischemia.May 31, 2012

A pharmacological review on asiatic acid and its derivatives.Mar 31, 2018

Anti-glioma activity and the mechanism of cellular uptake of asiatic acid-loaded solid lipid nanoparticles.Mar 15, 2016

Anti-glycative effects of asiatic acid in human keratinocyte cells.Dec 31, 2013

Antifungal activity and potential mechanism of Asiatic acid alone and in combination with fluconazole against Candida albicans.Apr 09, 2021

Antimicrobial effect of asiatic acid against Clostridium difficile is associated with disruption of membrane permeability.Dec 31, 2017

Asiatic acid ameliorates acute hepatic injury by reducing endoplasmic reticulum stress and triggering hepatocyte autophagy.Aug 31, 2020

Asiatic acid attenuates lipopolysaccharide-induced injury by suppressing activation of the Notch signaling pathwayMar 12, 2018

Asiatic acid attenuates myocardial ischemia/reperfusion injury. Sep 18, 2016

Asiatic Acid

View the Evidence:
114 Abstracts with Asiatic Acid Research