Astragalus

Name	AC	CK
Diabetic Nephropathy	17	66
Myocarditis: Viral	3	32
Colorectal Cancer	8	28
Heart Failure	7	28
Myocardial Ischemia	4	26
Inflammation	14	21
Cerebral Ischemia	11	19
Lipopolysaccharide-Induced Toxicity	13	18
Cardiovascular Diseases	7	17
Oxidative Stress	9	17
Diabetes Mellitus: Type 2	7	14
Endothelial Dysfunction	9	14
Chronic Fatigue Syndrome	2	12
Liver Cancer	10	12
Lung Cancer	3	12
Water Retention	2	12
Aging	7	11
Hypoxia	9	11
Leukemia	2	11
Myasthenia Gravis	2	11
Anemia: Aplastic	1	10
Anorexia: Cancer-Associated	1	10
Chemotherapy	1	10
Chemotherapy-Induced Toxicity	1	10
Diabetic Complications	7	10
Edema	1	10
Encephalomyocarditis Virus	1	10
Herpes family viruses	1	10
Herpes: Keratitis	1	10
Immune Dysregulation: TH1/TH2 imbalance	1	10
Keratitis	1	10
Leukopenia	1	10
Lupus Erythematosus: Systemic	1	10
Myocarditis	1	10
Nephritis	1	10
Nephropathy:Membranous, Idiopathic	1	10
Tonsillitis	1	10
Liver Fibrosis	6	9
Osteoporosis	3	9
Brain Ischemia	5	8
Breast Cancer	6	8
Chemotherapy-Induced Toxicity: Cisplatin	4	8
Kidney Fibrosis	4	8
Parkinson's Disease	6	8
Chemotherapy-Induced Toxicity: Doxorubicin	4	7
Brain Inflammation	3	6
Coxsackievirus Infections	3	6
Diabetes Mellitus: Type 1	3	6
Hypertension: Pulmonary	3	6
Kidney Damage	3	6
Myocardial Fibrosis	3	6
Myocardial Infarction	3	6
Nonalcoholic fatty liver disease (NAFLD)	2	6
Obesity	3	6
Osteoarthritis	2	6
Ovarian Cancer	2	6
Alzheimer's Disease	4	5
Iron Overload	3	5
Kidney Stones	1	5
Lipid Peroxidation	4	5
Stroke	4	5
Stroke: Ischemic	3	5
Alcohol Toxicity	2	4
Anxiety	1	4
Bisphenol Toxicity	1	4
Cancers: Drug Resistant	4	4
Carcinoma: Non-Small-Cell Lung	4	4
Cardiac Hypertrophy	2	4
Cardiomyopathy	3	4
Chemotherapy-Induced Kidney Damage	2	4
Cognitive Decline/Dysfunction	2	4
Colitis	2	4
Depression	1	4
Gastric Ulcer	2	4
Gestational Diabetes	2	4
Hypertension	2	4
Lung Injury: Acute	2	4
Pre-Eclampsia	2	4
Pulmonary Hypertension	2	4
Radiation	3	4
Schizophrenia	1	4
Subarachnoid hemorrhage	2	4
Ulcerative Colitis	2	4
DNA damage	2	3
Diabetes	2	3
Diabetic Retinopathy	2	3
Influenza	3	3
Insulin Resistance	2	3
Kidney Damage: Chemically-Induced	2	3
Liver Cirrhosis	2	3
Liver Damage	2	3
Multiple Sclerosis	2	3
Sepsis	2	3
Wound Healing	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Adiponectin: Low Levels	1	2
Air Pollution Linked Toxicity	1	2
Allergic Rhinitis	1	2
Anoxia	1	2
Aortic Aneurysm	1	2
Arthritis	1	2
Aspirin-Induced Toxicity	1	2
Asthma	2	2
Atherosclerosis	2	2
Brain: Oxidative Stress	1	2
Bronchitis	1	2
Cachexia: Cancer	1	2
Cancers: All	2	2
Cardiovascular Disease	1	2
Cerebral Stroke	1	2
Cervical Cancer	1	2
Chemically-Induced Liver Damage	2	2
Chemotherapy-Induced Toxicity: Adriamycin	1	2
Chemotherapy-Induced Toxicity: Bleomycin	1	2
Chronic Kidney Disease (CKD)	1	2
Chronic Obstructive Pulmonary Disease	1	2
Constipation	1	2
Coronavirus Disease	1	2
Coronavirus Infection	1	2
Cytomegalovirus Infections	1	2
Depressive Disorder	1	2
Diabetes: Oxidative Stress	1	2
Diabetic Ketoacidosis	1	2
Diarrhea: Antibiotic-Associated	1	2
Endometritis	1	2
Endothelial Damage	1	2
Gastric Cancer	1	2
Gastric Cancer: Prevention	1	2
Glioma	2	2
Heart Disease	1	2
Hepatitis B	1	2
High Fat Diet	1	2
High Fructose Diet	1	2
High Homocysteine	1	2
Homocysteine: Elevated	1	2
Hydrogen Peroxide Induced Toxicity	2	2
Hyperglycemia	1	2
Hypertrophy: Right Ventricular	1	2
Hypoglycemia	1	2
IgA Nephropathy	1	2
Infertility: Male	1	2
Irritable Bowel Syndrome	1	2
Jaundice: Post-Hepatic/Obstructive	1	2
Kidney Diseases	1	2
Lead Poisoning	1	2
Lung Injury: Smoke-Induced	1	2
Lupus Nephritis	1	2
Macular Degeneration	1	2
Metabolic Syndrome X	1	2
Obstructive uropathy	1	2
Periodontitis	1	2
Prostate Cancer	2	2
Proteinuria	1	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Radiation Induced Illness	1	2
Renal tubulointerstitial fibrosis	1	2
Sleep Apnea: Obstructive	1	2
Stroke: Attenuation/Recovery	1	2
Surgery: Anesthesiology	1	2
Thrombocytopenia	1	2
Ultraviolet Radiation Induced Damage	2	2
Acute Respiratory Distress Syndrome	1	1
Advanced Glycation End products (AGE)	1	1
Aging Skin	1	1
Aging: Brain	1	1
Allergies	1	1
Amyotrophic Lateral Sclerosis	1	1
Autoimmune Diseases	1	1
Brain Hypoxia	1	1
Brain Injury: Hippocampal Damage	1	1
Breast Cancer: Triple Negative	1	1
Cancer Metastasis	1	1
Chemotherapy Induced Myelotoxicity	1	1
Colon Cancer	1	1
Common Cold	1	1
Coronary Artery Disease	1	1
Dengue	1	1
Diabetic Ulcer	1	1
Endometriosis	1	1
Escherichia coli Infections	1	1
Fibrosis	1	1
Glomerulonephritis	1	1
HIV Infections	1	1
Hepatic Steatosis	1	1
Hepatoma: Multidrug Resistant	1	1
Hyperpigmentation	1	1
Ischemia	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Melasma	1	1
Memory Disorders	1	1
Middle Cerebral Artery Occlusion (MCAO)	1	1
Mitochondrial Dysfunction	1	1
Myelodysplastic Syndromes	1	1
Myelotoxicity	1	1
Necrotising enterocolitis	1	1
Neurodevelopmental Disorders	1	1
Neurological Conditions	1	1
Neutropenia: Chemotherapy Induced	1	1
Peritonitis	1	1
Pulmonary Fibrosis	1	1
Silicosis	1	1
Squamous cell carcinoma	1	1
Statin-Induced Pathologies	1	1
Testosterone: Too Low	1	1
Toxoplasma gondii Infection	1	1
Toxoplasmosis	1	1
Triglycerides: Elevated	1	1
Tuberculosis	1	1
Urinary Tract Infections	1	1

Name	AC	CK
Anti-Inflammatory Agents	70	149
Cardioprotective	33	98
Antioxidants	50	97
Renoprotective	22	81
Tumor Necrosis Factor (TNF) Alpha Inhibitor	31	81
Anti-Apoptotic	37	77
Neuroprotective Agents	40	65
Interleukin-6 Downregulation	27	49
Interleukin-1 beta downregulation	26	46
NF-kappaB Inhibitor	15	29
Anti-Fibrotic	17	28
Immunomodulatory	14	28
Nrf2 activation	16	26
Antiproliferative	22	25
Chemoprotective Agents	10	18
MicroRNA modulator	13	18
Apoptotic	16	17
Hepatoprotective	11	16
Natriuretic Agents	2	12
Antiviral Agents	7	10
Diuretics	1	10
Neurogenesis	5	10
Anti-metastatic	7	9
Chemosensitizer	9	9
Heme oxygenase-1 up-regulation	6	9
Hypoglycemic Agents	5	9
Angiogenesis Inducing Agents	5	8
Chemopreventive	4	8
Gastroprotective	4	7
Hypolipidemic	2	7
Nitric Oxide Inhibitor	2	7
Anticarcinogenic Agents	3	6
Antidepressive Agents	2	6
Chemotherapeutic	6	6
Radioprotective	4	6
Gastrointestinal Agents	3	5
Malondialdehyde Down-regulation	4	5
Osteogenic	1	5
Postaglandin PGE2 downregulation	1	5
Transforming growth factor beta (TGF-β) inhibitor	5	5
Vascular Endothelial Growth Factor Inhibitors	3	5
Angiotensin-Converting Enzyme Inhibitors	2	4
Anti-Anxiety Agents	1	4
Autophagy Inhibitors	4	4
Autophagy Up-regulation	4	4
Cyclooxygenase 2 Inhibitors	2	4
Cytoprotective	2	4
Interleukin-17 downregulation	2	4
Interleukin-18 down-regulation	2	4
Matrix metalloproteinase-2 (MMP-2) inhibitor	3	4
Superoxide Dismutase Up-regulation	3	4
Telomerase Upregulation	3	4
Vasodilator Agents	2	4
Wnt/β-catenin signaling pathway modulation	2	4
Antihypertensive Agents	2	3
Immunomodulatory: Th17 downregulation	2	3
Immunostimulatory	2	3
Anti-Cachexic Agents	1	2
Antidiarrheals	1	2
Antineoplastic Agents	2	2
Atrial Natriuretic Factor Modulation	1	2
Brain-derived neurotrophic factor modulator	1	2
Cell cycle arrest	2	2
Cyclooxygenase 1 Inhibitor	1	2
Fertility Agents: Male	1	2
Gluconeogenesis Inhibitor	1	2
Heat Shock Protein Inducer	1	2
Histone deacetylase inhibitor	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	2
Interferon Gamma Reducer	1	2
Interleukin-2 Downregulation	1	2
Interleukin-8 downregulation	2	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	2
Neuritogenic	2	2
Osteoprotective	1	2
Photoprotective	2	2
STAT3 Inhibitor	1	2
Angiogenesis Modulating Agents	1	1
Anti-Bacterial Agents	1	1
Antiparasitic Agents	1	1
Antiprotozoal Agents	1	1
Cyclin-Dependent Kinase Inhibitor: P16	1	1
Enzyme Inhibitors	1	1
Hematopoietic	1	1
Insulin Sensitizers	1	1
Interleukin-10 downregulation	1	1
Interleukin-10 upregulation	1	1
Nitric Oxide Enhancer	1	1
Protein Kinase Inhibitors	1	1
RANTES (CCL5) Inhibitor	1	1
Vascular Endothelial Growth Factor A Inhibitor	1	1

[+]

Astragaloside IV exerted potential cardioprotective function in acute myocardial ischemia/reperfusion injury.Dec 31, 2017

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Pubmed Data : Front Physiol. 2018 ;9:795. Epub 2018 Jul 3. PMID: 30018562

Article Published Date : Dec 31, 2017

Study Type : Meta Analysis, Review

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Substances : Astragaloside

Diseases : Myocardial Ischemia

Pharmacological Actions : Cardioprotective

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Astragaloside IV exerts cardioprotection in animal models of viral myocarditis.Dec 31, 2018

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Pubmed Data : Nutrients. 2022 Oct 17 ;14(20). Epub 2022 Oct 17. PMID: 36297022

Article Published Date : Oct 16, 2022

Study Type : Human Study

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Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Apr;29(4):305-8. PMID: 19526753

Astralagus and Red Sage (Salvia miltiorrhiza) significantly decreased fatigue in Chronic Fatigue Syndrome. Jun 01, 2009

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Pubmed Data : Complement Ther Med. 2009 Jun;17(3):141-6. Epub 2009 Jan 23. PMID: 19398067

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Pubmed Data : Mater Sci Eng C Mater Biol Appl. 2020 May ;110:110732. Epub 2020 Feb 6. PMID: 32204043

Article Published Date : May 01, 2020

Study Type : Human In Vitro

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Substances : Astragalus, Selenium

Diseases : Kidney Stones

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Astragaloside IV in hypoxic pulmonary hypertension.Aug 01, 2022

Article Published Date : Jun 30, 2017

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Renoprotective

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Astragaloside attenuates myocardial injury.May 31, 2017

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Pubmed Data : Mol Med Rep. 2017 Jun ;15(6):4015-4020. Epub 2017 Apr 27. PMID: 28487976

Article Published Date : May 31, 2017

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Myocardial Infarction

Pharmacological Actions : Cardioprotective

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Astragaloside could efficiently improve lipid metabolism in obese mice.Jul 21, 2016

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Pubmed Data : Pharmacology. 2019 Dec 11:1-9. Epub 2019 Dec 11. PMID: 31825924

Article Published Date : Dec 10, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Cerebral Ischemia

Pharmacological Actions : Neuroprotective Agents

[+]

Astragaloside IV alleviates cerebral ischemia-reperfusion injury. Dec 31, 2020

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Pubmed Data : Am J Transl Res. 2020 ;12(7):3512-3521. Epub 2020 Jul 15. PMID: 32774716

Article Published Date : Dec 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Proteinuria

Pharmacological Actions : Cytoprotective, Wnt/β-catenin signaling pathway modulation

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Astragaloside IV alleviates renal tubular EMT through the CX3CL1-RAF/MEK/ERK signaling pathway.Dec 31, 2021

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Pubmed Data : Molecules. 2018 Aug 14 ;23(8). Epub 2018 Aug 14. PMID: 30110942

Article Published Date : Aug 13, 2018

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Astragaloside IV attenuates cerebral ischemia‑reperfusion injury.Dec 31, 2020

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Pubmed Data : Mol Med Rep. 2021 Jan ;23(1). Epub 2020 Nov 25. PMID: 33236156

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Pulmonary Hypertension

Pharmacological Actions : Cytoprotective

[+]

Astragaloside IV attenuates indoxyl sulfate-induced injury of renal tubular epithelial cells.Feb 07, 2023

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Astragaloside IV inhibits hepatocellular carcinoma by continually suppressing the development of fibrosis and regulating pSmad3C/3L and Nrf2/HO-1 pathways.Jun 18, 2021

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Pubmed Data : J Ethnopharmacol. 2021 Jun 19 ;279:114350. Epub 2021 Jun 19. PMID: 34157326

Article Published Date : Jun 18, 2021

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Liver Cancer

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Chemopreventive, Heme oxygenase-1 up-regulation, Nrf2 activation

[+]

Astragaloside IV inhibits mitochondrial-dependent apoptosis of the dorsal root ganglion in diabetic peripheral neuropathy.Dec 31, 2020

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Pubmed Data : Mol Neurobiol. 2017 May ;54(4):2939-2949. Epub 2016 Mar 29. PMID: 27023226

Article Published Date : Apr 30, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Astragaloside

Pharmacological Actions : Neuroprotective Agents

[+]

Astragaloside IV may be a promising agent for the treatment of uremia toxin-induced injury. Sep 02, 2018

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Pubmed Data : BMC Pharmacol Toxicol. 2018 Sep 3 ;19(1):53. Epub 2018 Sep 3. PMID: 30176914

Article Published Date : Sep 02, 2018

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Antioxidants, Renoprotective

[+]

Astragaloside IV may reduce liver steatosis, hepatocyte oxidative stress and apoptosis, and decrease liver inflammation.Dec 31, 2020

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Pubmed Data : Int Immunopharmacol. 2021 Feb ;91:107290. Epub 2020 Dec 29. PMID: 33383446

Article Published Date : Jan 31, 2021

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Air Pollution Linked Toxicity, Lung Injury: Acute

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor

[+]

Astragaloside IV modulates TGF‐β1‐dependent epithelial‐mesenchymal transition in bleomycin‐induced pulmonary fibrosisAug 31, 2018

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Astragaloside IV protects against ischemia/reperfusion (I/R)-induced kidney injury based on the Keap1-Nrf2/ARE signaling pathway.Jul 31, 2022

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Pubmed Data : J Inflamm Res. 2021 ;14:4707-4721. Epub 2021 Sep 16. PMID: 34557015

Article Published Date : Dec 31, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Air Pollution Linked Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Astragaloside IV protects rat gastric mucosa against aspirin-induced damage.Nov 30, 2016

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Pubmed Data : Int Immunopharmacol. 2016 Dec ;41:47-55. Epub 2016 Nov 2. PMID: 27816726

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Pubmed Data : Iran J Basic Med Sci. 2022 Jul ;25(7):882-889. PMID: 36033957

Article Published Date : Jun 30, 2022

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Pharmacological Actions : Antiproliferative , Apoptotic

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Astragaloside IV relieves atherosclerosis and hepatic steatosis.Dec 31, 2021

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Pubmed Data : Biochim Biophys Acta Mol Cell Res. 2020 Sep 15 ;1868(1):118853. Epub 2020 Sep 15. PMID: 32941941

Pubmed Data : Nutr J. 2008;7:11. Epub 2008 Apr 21. PMID: 11189248

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Astragalus

Diseases : Hypertrophy: Right Ventricular, Pulmonary Hypertension

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Astragalus contains a compound called astragaloside IV which improves homocysteine-induced acute phase endothelial dysfunction via antioxidation.Jan 01, 2010

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Pubmed Data : Biol Pharm Bull. 2010;33(4):641-6. PMID: 20410599

Article Published Date : Jan 01, 2010

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Astragalus membranaceus and Salvia miltiorrhiza ameliorate hypertensive renal damage.Dec 31, 2021

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Pubmed Data : Food Funct. 2022 Jun 21. Epub 2022 Jun 21. PMID: 35726797

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Pubmed Data : Lipids Health Dis. 2023 Jan 21 ;22(1):9. Epub 2023 Jan 21. PMID: 36670439

Article Published Date : Jan 20, 2023

Study Type : Animal Study

Additional Links

Substances : Astragalus

Diseases : Cachexia, Heart Failure, Inflammation, Obesity

Additional Keywords : Polysaccharides

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Astragalus polysaccharide protects sepsis model rats after cecum ligation and puncture.Dec 31, 2021

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Pubmed Data : Front Pharmacol. 2022 ;13:1103557. Epub 2023 Jan 9. PMID: 36699092

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Astragalus

Diseases : Myocardial Ischemia

Pharmacological Actions : Angiogenesis Inducing Agents, Cardioprotective

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Astragalus saponins and glycyrrhizic acid synergistically alleviated hepatic fibrosis.Jun 05, 2016

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Pubmed Data : J Ethnopharmacol. 2016 Jun 6 ;190:83-90. Epub 2016 Jun 6. PMID: 27282665

Article Published Date : Jun 05, 2016

Study Type : Animal Study

Additional Links

Substances : Astragalus, Licorice

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective

Additional Keywords : Natural Substance Synergy

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Astragalus saponins and its main constituents ameliorate ductular reaction and liver fibrosis.Dec 31, 2021

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Pubmed Data : Am J Chin Med. 2015 ;43(7):1419-38. Epub 2015 Oct 18. PMID: 26477799

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Astragalus, Ginsenosides, Panax Notoginseng

Diseases : Brain Ischemia, Inflammation

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Phytotherapy

[+]

Compounds found within Astragalus elevate circulating adiponectin levels resulting in the amelioration of insulin resistance and glucose intolerance in obese mice. Feb 01, 2009

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Pubmed Data : Endocrinology. 2009 Feb;150(2):625-33. Epub 2008 Oct 16. PMID: 18927219

Article Published Date : Feb 01, 2009

Study Type : Animal Study

Additional Links

Substances : Astragalus

Diseases : Adiponectin: Low Levels, Insulin Resistance, Obesity

[+]

Compounds in Astragalus protect against homocysteine-induced injury to the lining of the arteries.Apr 01, 2007

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Pubmed Data : Vascul Pharmacol. 2007 Apr;46(4):278-85. Epub 2006 Nov 10. PMID: 17196887

Intake of flavonoids from Astragalus membranaceus ameliorated brain impairment in diabetic mice.Feb 11, 2022

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Pubmed Data : Chin Med. 2022 Feb 12 ;17(1):22. Epub 2022 Feb 12. PMID: 35151348

Article Published Date : Feb 11, 2022

Study Type : Animal Study

Additional Links

Substances : Astragalus, Flavonoids

Diseases : Diabetes: Cognitive Dysfunction

Pharmacological Actions : Gastrointestinal Agents, Neuroprotective Agents

Additional Keywords : Gut-brain Axis

[+]

Investigation on the potential targets of Astragaloside IV against intracerebral hemorrhage.Jun 16, 2022

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Pubmed Data : Bioorg Chem. 2022 Jun 17 ;127:105975. Epub 2022 Jun 17. PMID: 35728292

Article Published Date : Jun 16, 2022

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Intracerebral Hemorrhage

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor

[+]

Mechanism of Astragalus membranaceus alleviating acquired hyperlipidemia induced by high-fat diet.Feb 22, 2022

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Pubmed Data : Nutrients. 2022 Feb 23 ;14(5). Epub 2022 Feb 23. PMID: 35267929

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Pubmed Data : Phytother Res. 2017 Sep ;31(9):1410-1418. Epub 2017 Jul 28. PMID: 28752625

Article Published Date : Aug 31, 2017

Study Type : Animal Study

Additional Links

Substances : Astragaloside, Paeoniflorin

Diseases : Brain Ischemia

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Natural Substance Synergy

[+]

Photoreceptor and vision protective effects of astragaloside IV in mice model with light-evoked retinal damage.Aug 31, 2022

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Pubmed Data : Front Pharmacol. 2021 ;12:714322. Epub 2021 Aug 31. PMID: 34531745

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Astragalus, Turmeric

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Gastrointestinal Agents

[+]

Suppressing NK cells by astragaloside IV protects against acute ischemic stroke.Dec 31, 2020

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Pubmed Data : Int Immunopharmacol. 2017 Jan ;42:18-24. Epub 2016 Nov 14. PMID: 27855303

Article Published Date : Dec 31, 2016

Study Type : Animal Study

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Substances : Astragaloside

Diseases : Inflammation, Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor

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Pubmed Data : Pharm Biol. 2020 Dec ;58(1):328-332. PMID: 32356474

Article Published Date : Nov 30, 2020

Study Type : In Vitro Study

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Substances : Astragaloside, Puerarin

Additional Keywords : Food Bioavailability Enhancers

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Positive effect of Astragaloside IV on neurite outgrowth via talin-dependent integrin signaling and microfilament force.Aug 26, 2020

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Pubmed Data : J Cell Physiol. 2020 Aug 27. Epub 2020 Aug 27. PMID: 32853433

Article Published Date : Aug 26, 2020

Study Type : In Vitro Study

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Substances : Astragaloside

Pharmacological Actions : Neuritogenic, Neuroprotective Agents

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Protective role of Astragaloside IV in chronic glomerulonephritis by activating autophagy through PI3K/AKT/AS160 pathway.Jul 28, 2020

Pubmed Data : Toxicol Appl Pharmacol. 2018 Oct 29 ;362:105-115. Epub 2018 Oct 29. PMID: 30385269

Article Published Date : Oct 28, 2018

Study Type : In Vitro Study

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Substances : Astragaloside

Diseases : Autoimmune Diseases, Multiple Sclerosis

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation

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Astragaloside exerts anti-photoaging effects in UVB-induced premature senescence of rat dermal fibroblasts.Sep 13, 2018

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Pubmed Data : Arch Biochem Biophys. 2018 Sep 14 ;657:31-40. Epub 2018 Sep 14. PMID: 30222953

Article Published Date : Sep 13, 2018

Study Type : In Vitro Study

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Substances : Astragaloside

Diseases : Ultraviolet Radiation Induced Damage

Pharmacological Actions : Autophagy Inhibitors, Photoprotective

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Astragaloside II sensitizes human hepatocellular carcinoma cells to 5-fluorouracil.May 31, 2017

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Pubmed Data : Exp Ther Med. 2021 Oct ;22(4):1076. Epub 2021 Jul 28. PMID: 34447469

Article Published Date : Sep 30, 2021

Study Type : In Vitro Study

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Substances : Astragaloside

Diseases : Heart Failure

Pharmacological Actions : Cardioprotective

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Astragaloside IV alleviates heart failure via activating PPARα to switch glycolysis to fatty acid β-oxidation.Jun 01, 2017

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Pubmed Data : Exp Ther Med. 2019 Jun ;17(6):4409-4416. Epub 2019 Apr 17. PMID: 31086575

Article Published Date : May 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Nrf2 activation

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Astragaloside IV ameliorates high glucose‑induced renal tubular epithelial‑mesenchymal transition.Nov 25, 2018

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Pubmed Data : Int J Mol Med. 2018 Nov 26. Epub 2018 Nov 26. PMID: 30483732

Article Published Date : Nov 25, 2018

Study Type : In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Fibrotic, Renoprotective

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View the Evidence: 455 Abstracts with Astragalus Research

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Astragaloside IV exerted potential cardioprotective function in acute myocardial ischemia/reperfusion injury.Dec 31, 2017

Astragaloside IV exerts cardioprotection in animal models of viral myocarditis.Dec 31, 2018

Astragaloside IV exerts renal protective effects in animals with diabetes mellitus through multiple signalling pathways.Sep 14, 2020

Effectiveness of medicinal plants for glycaemic control in type 2 diabetes.Dec 31, 2020

Evaluation of astragaloside IV in hepatic fibrosis: A meta-analysis. Apr 01, 2021

Specific combinations of traditional medicines appeared to produce higher contributions to tumor response rate than the TMs individually.Aug 05, 2015

These findings suggest that astragaloside IV is a multifaceted renoprotective candidate drug for diabetic nephropathy.Dec 31, 2019

An herbal decoction that includes Astragalus shows potential for management of cancer-related anorexia.Feb 11, 2010

Astragalosides supplementation enhances intrinsic muscle repair capacity following eccentric exercise-induced injury.Oct 16, 2022

Astragalus combined with chemotherapy can significantly improve the quality of life and the mean survival time in non-small cell lung cancer patients.Oct 01, 2003

Astragalus has a diuretic/natruiretic effect.Mar 28, 2008

Astragalus has a positive immunomodulatory effect in patients with myasthenia gravia. Apr 01, 2009

Astragalus has a significant effect on improving heart function in patients with congestive heart failure.Oct 01, 2001

Astragalus improves cardiac function in aged patients with Chronic Heart Failure.Sep 01, 2005

Astragalus improves cell immunity in viral myocarditis.Jun 01, 1995

Astragalus improves immune function in Herpes Simplex Keratitis.Jun 01, 2007

Astragalus increases the dentritic cell induction of Peripheral Mononuclearcells in Acute LeukemiaOct 01, 2005

Astragalus injection may be a useful approach for enhancing the efficacy of system lupus erythematoosus treatment. May 01, 2006

Astragalus may be an effective treatment against leukopenia. Aug 01, 1995

Astragalus may have a therapeutic effect in modulating immune function in children with recurrent tonsilitis.Jun 01, 1999

Astragalus may provide an ideal complementary treatment to chemotherapy.Mar 01, 2008

Astragalus may significantly improve Chronic Aplastic Anemia via recovery of hemopoietic function.May 01, 2004

Astralagus and Red Sage (Salvia miltiorrhiza) significantly decreased fatigue in Chronic Fatigue Syndrome. Jun 01, 2009

Astralagus may provide a safe and effective treatment ofr idiopathic membranous nephropathy. Dec 01, 2007

TA-65 improved key markers of cardiovascular disease risk.Dec 31, 2017

The new Chinese herbal preparation, Man-Shen-Ling (consisting of medicinal herbs such as Astragalus and Rehmannia) is safe and effective in treating chronic nephritis. May 01, 1993

Angelica and Astragalus could protect against oxidative stress-induced apoptosis in kidney epithelium.Feb 16, 2016

Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes.Jun 30, 2017

Astragaloside potentially serve as a promising and effective therapeutic agent for treating osteoarthritis patients.Jul 31, 2019

Astragalus polysaccharides inhibits ovarian cancer cell growth via microRNA-27a/FBXW7 signaling pathway.Mar 11, 2020

Radix astragalus isoflavones exhibit osteogenic activity.Jan 01, 2018

Selenized astragalus polysaccharide may be a candidate drug for the treatment and prevention of kidney stones.May 01, 2020

Astragaloside IV in hypoxic pulmonary hypertension.Aug 01, 2022

Astragaloside protects rat brain from microwave-induced functional injuries via restoring acetylcholine and normalizing electroencephalogram.Jul 15, 2020

A combination of Astagalus, Rhodiola Rosea and Sophora flavenscens ameliorates coxsackievirus B3 induced myocarditis in mice. Dec 01, 2007

A herbal decoction of astragalus and angelica promotes thrombopoiesis in the mouse model. Jul 06, 2009

Aastragaloside IV can alleviate inflammation and enhance immunity in rats with experimental periodontitis.Apr 24, 2019

Administration of astragaloside containing fluid led to a dramatic improvement in survival following crush syndrome.Sep 03, 2017

Alleviative effects of astragaloside IV on cyclophosphamide-induced oxidative damage and immunosuppression.Nov 07, 2022

Angiogenic function of astragaloside IV in rats with myocardial infarction occurs via the PKD1-HDAC5-VEGF pathway.Mar 31, 2019

Anti-anxiety and antidepressant-like effects of astragaloside IV and saponins extracted from Astragalus spinosus.Mar 04, 2021

Anti-inflammatory effects of a novel herbal extract in the muscle and spinal cord of an Amyotrophic lateral sclerosis.Dec 31, 2020

Antihypertension effect of astragaloside IV during cerebral ischemia reperfusion.Dec 31, 2022

AS IV is able to protect developing brain from anesthesia-induced neuroapoptosisAug 31, 2016

Astragaloside -IV prevents dopaminergic neurodegeneration in Parkinson's disease.Apr 05, 2020

Astragaloside A protects against photoreceptor degeneration.Dec 31, 2021

Astragaloside alleviates alcoholic fatty liver disease by suppressing oxidative stress.May 10, 2021

Astragaloside attenuated cisplatin-mediated renal injury.Jun 30, 2017

Astragaloside attenuates myocardial injury.May 31, 2017

Astragaloside could efficiently improve lipid metabolism in obese mice.Jul 21, 2016

Astragaloside exerts its protective effect against sepsis-induced acute lung injury in rats.Apr 30, 2016

Astragaloside has potential in reversing intestinal metaplasia and dysplasia of gastric precancerous lesions and protecting the gastric mucosa.Jul 31, 2018

Astragaloside II alleviates the symptoms of experimental ulcerative colitis in vitro and in vivo.Dec 31, 2018

Astragaloside II ameliorated podocyte injury and mitochondrial dysfunction in streptozotocin-induced diabetic rats.Dec 31, 2020

Astragaloside II promotes intestinal epithelial repair.Sep 25, 2017

Astragaloside inhibits hepatic fibrosis by modulation of TGF-β1/Smad signalling pathway.Dec 31, 2017

Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy.Apr 23, 2020

Astragaloside IV alleviated heart failure by promoting angiogenesis through JAK-STAT3 pathway.Nov 30, 2019

Astragaloside IV alleviates cerebral ischemia-reperfusion injury.Dec 10, 2019

Astragaloside IV alleviates cerebral ischemia-reperfusion injury. Dec 31, 2020

Astragaloside IV alleviates doxorubicin induced cardiomyopathy by inhibiting NADPH oxidase derived oxidative stress.Sep 14, 2019

Astragaloside IV alleviates infarction induced cardiomyocyte injury.Dec 31, 2021

Astragaloside IV alleviates intestinal barrier dysfunction. Dec 31, 2021

Astragaloside IV alleviates lipopolysaccharide-induced acute kidney injury.Mar 21, 2017

Astragaloside IV alleviates lipopolysaccharide‐induced preeclampsia‐like phenotypes via suppressing the inflammatory responses.Oct 21, 2020

Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy.May 31, 2021

Astragaloside IV alleviates mouse slow transit constipation.Jul 05, 2020

Astragaloside IV alleviates myocardial damage induced by type 2 diabetes via improving energy metabolism.Oct 31, 2019

Astragaloside IV alleviates myocardial ischemia-reperfusion injury.Sep 11, 2019

Astragaloside IV alleviates placental oxidative stress and inflammation in GDM mice.Sep 30, 2020

Astragaloside IV alleviates PM2.5-caused lung toxicity by inhibiting inflammasome-mediated pyroptosis.Apr 20, 2022

Astragaloside IV alleviates puromycin aminonucleoside-induced podocyte cytoskeleton injury through the Wnt/PCP pathway.Dec 31, 2019

Astragalus

View the Evidence:
455 Abstracts with Astragalus Research