Astragalus

Name	AC	CK
Diabetic Nephropathy	29	85
Diabetes Mellitus: Type 2	21	55
Heart Failure	12	54
Inflammation	28	45
Cerebral Ischemia	20	35
Liver Fibrosis	10	34
Colorectal Cancer	11	32
Myocarditis: Viral	3	32
Myocardial Ischemia	7	31
Oxidative Stress	19	30
Lipopolysaccharide-Induced Toxicity	20	29
Liver Cirrhosis	4	24
Liver Cancer	17	23
Cardiovascular Diseases	10	21
Endothelial Dysfunction	12	18
Nonalcoholic fatty liver disease (NAFLD)	8	17
Lung Cancer	6	16
Pulmonary Fibrosis	8	16
Brain Inflammation	8	15
Myasthenia Gravis	4	15
Myocardial Infarction	8	15
Kidney Damage	8	14
Kidney Fibrosis	8	14
Obesity	7	14
Stroke: Ischemic	8	14
Aging	8	13
Alzheimer's Disease	8	13
Brain Ischemia	8	13
Hypoxia	11	13
Sepsis	8	13
Breast Cancer	8	12
Chemotherapy-Induced Toxicity: Doxorubicin	7	12
Chronic Fatigue Syndrome	2	12
Coronavirus Disease (Covid-19)	2	12
Diabetic Complications	9	12
Water Retention	2	12
Atherosclerosis	7	11
Escherichia coli Infections	2	11
Leukemia	2	11
Parkinson's Disease	8	11
Stroke	8	11
Urinary Tract Infections	2	11
Air Pollution Linked Toxicity	5	10
Anemia: Aplastic	1	10
Anorexia: Cancer-Associated	1	10
Chemotherapy	1	10
Chemotherapy-Induced Toxicity	1	10
Chemotherapy-Induced Toxicity: Cisplatin	5	10
Edema	1	10
Encephalomyocarditis Virus	1	10
Fatigue	1	10
Herpes family viruses	1	10
Herpes: Keratitis	1	10
Hypertension	5	10
Hypertension: Pulmonary	5	10
Immune Dysregulation: TH1/TH2 imbalance	1	10
Keratitis	1	10
Leukopenia	1	10
Lupus Erythematosus: Systemic	1	10
Muscle Damage: Exercise-Induced	1	10
Myocarditis	1	10
Nephritis	1	10
Nephropathy:Membranous, Idiopathic	1	10
Osteoporosis	4	10
Tonsillitis	1	10
Hyperglycemia	5	9
Radiation	6	9
Bisphenol Toxicity	2	8
Colitis	4	8
Diabetes Mellitus: Type 1	5	8
Lipid Peroxidation	6	8
Liver Damage	5	8
Myocardial Fibrosis	4	8
Ulcerative Colitis	5	8
Cardiomyopathy	5	7
DNA damage	3	7
Fibrosis	3	7
Insulin Resistance	5	7
Osteoarthritis	3	7
Ovarian Cancer	3	7
Asthma	4	6
Carcinoma: Non-Small-Cell Lung	6	6
Cardiac Hypertrophy	3	6
Chemotherapy-Induced Toxicity: Cyclophosphamide	3	6
Chronic Obstructive Pulmonary Disease	3	6
Cognitive Decline/Dysfunction	3	6
Coxsackievirus Infections	3	6
Depression	2	6
Diabetes: Cognitive Dysfunction	3	6
Lung Injury: Acute	3	6
Wound Healing	4	6
Alcoholic Liver Disease	3	5
Cancers: All	5	5
Cancers: Drug Resistant	5	5
Chemotherapy-Induced Kidney Damage	3	5
Chronic Kidney Disease (CKD)	3	5
Colon Cancer	3	5
Constipation	2	5
Coronary Artery Disease	3	5
Diabetic Retinopathy	4	5
Gastric Cancer	4	5
Iron Overload	3	5
Kidney Stones	1	5
Memory Disorders	3	5
Alcohol Toxicity	2	4
Allergic Rhinitis	2	4
Anxiety	1	4
Brain: Oxidative Stress	3	4
Chemically-Induced Liver Damage	3	4
Endothelial Damage	2	4
Gastric Ulcer	2	4
Gestational Diabetes	2	4
Heart Disease	2	4
High Fat Diet	2	4
Intracerebral Hemorrhage	2	4
Ischemia	3	4
Kidney Damage: Chemically-Induced	3	4
Liver Steatosis	2	4
Lung Damage	2	4
Multiple Sclerosis	3	4
Periodontitis	3	4
Pre-Eclampsia	2	4
Prostate Cancer	3	4
Pulmonary Hypertension	2	4
Retinal Degeneration: Light-Induced	2	4
Schizophrenia	1	4
Subarachnoid hemorrhage	2	4
Aging: Brain	2	3
Amyotrophic Lateral Sclerosis	2	3
Cervical Cancer	2	3
Chemotherapy-Induced Toxicity: Bleomycin	2	3
Coronavirus Infection	2	3
Diabetes	2	3
Glomerulonephritis	2	3
Hepatic Steatosis	2	3
Influenza	3	3
Necrotising enterocolitis	2	3
Peritonitis	2	3
Ultraviolet Radiation Induced Damage	3	3
Acetaminophen (Tylenol) Toxicity	1	2
Adiponectin: Low Levels	1	2
Aging: Liver	1	2
Altitude Sickness	1	2
Anoxia	1	2
Aortic Aneurysm	1	2
Arthritis	1	2
Aspirin-Induced Toxicity	1	2
Autoimmune Diseases	2	2
Breast Cancer: Triple Negative	2	2
Bronchitis	1	2
Cachexia	1	2
Cachexia: Cancer	1	2
Cardiovascular Disease	1	2
Cerebral Stroke	1	2
Chemotherapy-Induced Toxicity: Adriamycin	1	2
Chemotherapy-Induced Toxicity: Peripheral Neuropathy	1	2
Cytomegalovirus Infections	1	2
Depressive Disorder	1	2
Diabetes: Oxidative Stress	1	2
Diabetic Ketoacidosis	1	2
Diarrhea: Antibiotic-Associated	1	2
Dry Eye Syndromes	1	2
Endometritis	1	2
Enterovirus 71	2	2
Eye Damage	1	2
Gastric Cancer: Prevention	1	2
Glaucoma	1	2
Glioma	2	2
Hepatitis B	1	2
High Fructose Diet	1	2
High Homocysteine	1	2
Homocysteine: Elevated	1	2
Hydrogen Peroxide Induced Toxicity	2	2
Hyperlipidemia	1	2
Hypertrophy: Right Ventricular	1	2
Hypoglycemia	1	2
Hypoxia: Brain	1	2
IgA Nephropathy	1	2
Infertility: Male	1	2
Inflammatory Bowel Diseases	1	2
Irritable Bowel Syndrome	1	2
Ischemia: Myocardial	1	2
Jaundice: Post-Hepatic/Obstructive	1	2
Kidney Diseases	1	2
Lead Poisoning	1	2
Liver Damage: Drug-Induced	1	2
Lung Injury: Smoke-Induced	1	2
Lupus Nephritis	1	2
Macular Degeneration	1	2
Metabolic Diseases	1	2
Metabolic Syndrome X	1	2
Mitochondrial Dysfunction	2	2
Neurodegenerative Diseases	1	2
Neurological Disorders	1	2
Obstructive uropathy	1	2
Peripheral Neuropathies	1	2
Photooxidative Stress	1	2
Pregnancy Complications	1	2
Proteinuria	1	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Radiation Induced Illness	1	2
Renal tubulointerstitial fibrosis	1	2
Skin Cancer	1	2
Sleep Apnea: Obstructive	1	2
Spinal Cord Injuries	1	2
Squamous cell carcinoma	2	2
Stroke: Attenuation/Recovery	1	2
Surgery: Anesthesiology	1	2
Systemic Lupus Erythematosus	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Thrombocytopenia	1	2
Acute Respiratory Distress Syndrome	1	1
Advanced Glycation End products (AGE)	1	1
Aging Skin	1	1
Allergies	1	1
Animal Diseases: Porcine Circovirus Type 2 (PCV2)	1	1
Bone Diseases	1	1
Brain Hypoxia	1	1
Brain Injury: Hippocampal Damage	1	1
Cancer Metastasis	1	1
Cardiomegaly	1	1
Cataract	1	1
Chemotherapy Induced Myelotoxicity	1	1
Common Cold	1	1
Degenerative Disk Disease	1	1
Dementia	1	1
Dengue	1	1
Diabetic Ulcer	1	1
Endometrial Cancer	1	1
Endometriosis	1	1
Fatty Liver	1	1
HIV Infections	1	1
Hepatoma: Multidrug Resistant	1	1
Hyperpigmentation	1	1
Influenza A	1	1
Klebsiella Infections	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Lyme Disease	1	1
Melasma	1	1
Middle Cerebral Artery Occlusion (MCAO)	1	1
Myelodysplastic Syndromes	1	1
Myelotoxicity	1	1
Nephropathy	1	1
Nephropathy: Diabetic	1	1
Neurodevelopmental Disorders	1	1
Neurological Conditions	1	1
Neutropenia: Chemotherapy Induced	1	1
Psoriasis	1	1
Respiratory Diseases	1	1
Silicosis	1	1
Statin-Induced Pathologies	1	1
Testosterone: Too Low	1	1
Toxoplasma gondii Infection	1	1
Toxoplasmosis	1	1
Triglycerides: Elevated	1	1
Tuberculosis	1	1

Name	AC	CK
Anti-Inflammatory Agents	150	294
Antioxidants	98	167
Cardioprotective	58	157
Neuroprotective Agents	84	147
Tumor Necrosis Factor (TNF) Alpha Inhibitor	60	140
Renoprotective	45	114
Anti-Apoptotic	59	110
Interleukin-6 Downregulation	51	98
Anti-Fibrotic	38	87
Interleukin-1 beta downregulation	43	75
Hepatoprotective	27	63
Nrf2 activation	36	55
NF-kappaB Inhibitor	28	51
Antiproliferative	36	46
Immunomodulatory	27	45
Hypoglycemic Agents	10	37
Gastrointestinal Agents	17	33
Apoptotic	23	28
MicroRNA modulator	21	28
Chemoprotective Agents	15	26
Heme oxygenase-1 up-regulation	15	22
Anti-metastatic	15	18
Angiogenesis Inducing Agents	9	16
Hypolipidemic	7	16
Chemosensitizer	13	15
Antihypertensive Agents	7	14
Antiviral Agents	11	14
Autophagy Inhibitors	10	14
Chemopreventive	7	13
Autophagy Up-regulation	9	12
Natriuretic Agents	2	12
Anti-Bacterial Agents	2	11
Chemotherapeutic	10	11
Radioprotective	7	11
Diuretics	1	10
Interleukin-17 downregulation	6	10
Malondialdehyde Down-regulation	7	10
Neurogenesis	5	10
Gastroprotective	5	9
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	4	9
Anticarcinogenic Agents	4	8
Antidepressive Agents	3	8
Interleukin-18 down-regulation	5	8
Transforming growth factor beta (TGF-β) inhibitor	8	8
Cyclooxygenase 2 Inhibitors	3	7
Nitric Oxide Inhibitor	2	7
Immunomodulatory: Th17 downregulation	4	6
Immunostimulatory	4	6
Interleukin-8 downregulation	4	6
Osteogenic	2	6
Photoprotective	4	5
Postaglandin PGE2 downregulation	1	5
Superoxide Dismutase Up-regulation	4	5
Vascular Endothelial Growth Factor Inhibitors	3	5
Angiotensin-Converting Enzyme Inhibitors	2	4
Anti-Anxiety Agents	1	4
Brain-derived neurotrophic factor modulator	2	4
Cytoprotective	2	4
Genoprotective	1	4
Matrix metalloproteinase-2 (MMP-2) inhibitor	3	4
Osteoprotective	3	4
Telomerase Upregulation	3	4
Vasodilator Agents	2	4
Wnt/β-catenin signaling pathway modulation	2	4
Angiogenesis Inhibitors	2	3
Antineoplastic Agents	3	3
Interferon Gamma Reducer	2	3
Interleukin-10 upregulation	2	3
SIRT1 Activator	3	3
Anti-Cachexic Agents	1	2
Antidiarrheals	1	2
Antiparasitic Agents	2	2
Atrial Natriuretic Factor Modulation	1	2
Bcl-2 protein down-regulation	1	2
Catalase Up-Regulation	1	2
Cell cycle arrest	2	2
Cyclooxygenase 1 Inhibitor	1	2
Fertility Agents: Male	1	2
Gluconeogenesis Inhibitor	1	2
Heat Shock Protein Inducer	1	2
Histone deacetylase inhibitor	1	2
Insulin Sensitizers	2	2
Interleukin-2 Downregulation	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	2
Neuritogenic	2	2
Pancreato Protective Agents	2	2
STAT3 Inhibitor	1	2
Angiogenesis Modulating Agents	1	1
Antiprotozoal Agents	1	1
Chondroprotective	1	1
Cyclin-Dependent Kinase Inhibitor: P16	1	1
Enzyme Inhibitors	1	1
Hematopoietic	1	1
Interleukin-10 downregulation	1	1
Nitric Oxide Enhancer	1	1
Protein Kinase Inhibitors	1	1
RANTES (CCL5) Inhibitor	1	1
Transforming growth factor beta (TGF-β) upregulation	1	1
Tumor Suppressor Protein p53 Upregulation	1	1
Vascular Endothelial Growth Factor A Inhibitor	1	1
Vasoprotective	1	1

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Pubmed Data : Front Pharmacol. 2024 ;15:1394810. Epub 2024 Jun 20. PMID: 38966550

Article Published Date : Dec 31, 2023

Study Type : Human Study

Additional Links

Substances : Astragalus, Salvia miltiorrhiza

Diseases : Coronavirus Disease (Covid-19), Fatigue

Additional Keywords : Long Covid

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An herbal decoction that includes Astragalus shows potential for management of cancer-related anorexia.Feb 11, 2010

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Pubmed Data : Integr Cancer Ther. 2010 Feb 11. Epub 2010 Feb 11. PMID: 20150220

Article Published Date : Feb 11, 2010

Study Type : Human Study

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Substances : Astragalus

Diseases : Anorexia: Cancer-Associated

[+]

Astragalosides supplementation enhances intrinsic muscle repair capacity following eccentric exercise-induced injury.Oct 16, 2022

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Pubmed Data : Nutrients. 2022 Oct 17 ;14(20). Epub 2022 Oct 17. PMID: 36297022

Article Published Date : Oct 16, 2022

Study Type : Human Study

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Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Apr;29(4):305-8. PMID: 19526753

Astralagus and Red Sage (Salvia miltiorrhiza) significantly decreased fatigue in Chronic Fatigue Syndrome. Jun 01, 2009

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Pubmed Data : Complement Ther Med. 2009 Jun;17(3):141-6. Epub 2009 Jan 23. PMID: 19398067

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Pubmed Data : Curr Pharm Des. 2018 ;24(17):1905-1911. PMID: 29546832

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Pubmed Data : Acta Pharmacol Sin. 2017 Jul ;38(7):998-1008. Epub 2017 Mar 27. PMID: 28344322

Article Published Date : Jun 30, 2017

Study Type : Human In Vitro

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Substances : Astragaloside

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hypolipidemic

[+]

Astragaloside potentially serve as a promising and effective therapeutic agent for treating osteoarthritis patients.Jul 31, 2019

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Pubmed Data : Immunopharmacol Immunotoxicol. 2019 Aug ;41(4):497-503. Epub 2019 Jul 11. PMID: 31293216

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Pubmed Data : Mater Sci Eng C Mater Biol Appl. 2020 May ;110:110732. Epub 2020 Feb 6. PMID: 32204043

Article Published Date : May 01, 2020

Study Type : Human In Vitro

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Substances : Astragalus, Selenium

Diseases : Kidney Stones

[+]

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Pubmed Data : Transl Cancer Res. 2023 Dec 31 ;12(12):3703-3717. Epub 2023 Dec 21. PMID: 38193000

Article Published Date : Dec 30, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Cancer Stem Cells, Chemothapeutic Synergy: Paclitaxel

[+]

Astragaloside IV improves slow transit constipation by regulating gut microbiota and enterochromaffin cells.Dec 31, 2022

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Pubmed Data : Biomed Pharmacother. 2022 Oct ;154:113603. Epub 2022 Sep 7. PMID: 36942596

Article Published Date : Sep 30, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Inflammation, Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Autophagy Up-regulation

[+]

Astragaloside protects rat brain from microwave-induced functional injuries via restoring acetylcholine and normalizing electroencephalogram.Jul 15, 2020

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Pubmed Data : Environ Sci Pollut Res Int. 2020 Jul 16. Epub 2020 Jul 16. PMID: 32677014

Article Published Date : Jul 15, 2020

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Pubmed Data : Chin Med. 2023 Aug 4 ;18(1):97. Epub 2023 Aug 4. PMID: 37542273

Article Published Date : Aug 03, 2023

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Myasthenia Gravis

Pharmacological Actions : Gastrointestinal Agents, Interleukin-17 downregulation

[+]

Astragaloside IV ameliorates fat metabolism in the liver of ageing mice through targeting mitochondrial activity.Aug 16, 2021

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Pubmed Data : Mol Med Rep. 2021 Jan ;23(1). Epub 2020 Nov 25. PMID: 33236156

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Pulmonary Hypertension

Pharmacological Actions : Cytoprotective

[+]

Astragaloside IV attenuates indoxyl sulfate-induced injury of renal tubular epithelial cells.Feb 07, 2023

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Pubmed Data : Phytother Res. 2023 Mar 7. Epub 2023 Mar 7. PMID: 36882189

Article Published Date : Mar 06, 2023

Study Type : Animal Study

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Substances : Astragaloside

Diseases : Cardiomyopathy, Diabetes Mellitus: Type 2

Pharmacological Actions : Cardioprotective

[+]

Astragaloside IV attenuates myocardial ischemia-reperfusion injury.Dec 31, 2018

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Pubmed Data : Front Pharmacol. 2016 ;7:500. Epub 2016 Dec 21. PMID: 28066247

Article Published Date : Dec 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Apoptotic, Renoprotective

[+]

[+]

Astragaloside IV improves neurobehavior and promotes hippocampal neurogenesis.Jul 15, 2020

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Pubmed Data : Gene. 2024 Mar 1 ;897:148040. Epub 2023 Dec 6. PMID: 38065426

Article Published Date : Feb 29, 2024

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic

[+]

Pubmed Data : Mol Neurobiol. 2017 May ;54(4):2939-2949. Epub 2016 Mar 29. PMID: 27023226

Article Published Date : Apr 30, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Astragaloside

Pharmacological Actions : Neuroprotective Agents

[+]

Astragaloside IV may be a promising agent for the treatment of uremia toxin-induced injury. Sep 02, 2018

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Pubmed Data : BMC Pharmacol Toxicol. 2018 Sep 3 ;19(1):53. Epub 2018 Sep 3. PMID: 30176914

Article Published Date : Sep 02, 2018

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Antioxidants, Renoprotective

[+]

Astragaloside IV may reduce liver steatosis, hepatocyte oxidative stress and apoptosis, and decrease liver inflammation.Dec 31, 2020

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Pubmed Data : FEBS Open Bio. 2021 Jan 14. Epub 2021 Jan 14. PMID: 33445204

Article Published Date : Jan 13, 2021

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Iron Overload, Osteoporosis

Pharmacological Actions : Osteoprotective

Additional Keywords : Mesenchymal Stem Cells

[+]

Astragaloside IV protects against ischemia/reperfusion (I/R)-induced kidney injury based on the Keap1-Nrf2/ARE signaling pathway.Jul 31, 2022

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Pubmed Data : Biochim Biophys Acta Mol Cell Res. 2020 Sep 15 ;1868(1):118853. Epub 2020 Sep 15. PMID: 32941941

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Pubmed Data : Life Sci. 2021 Jun 15 ;275:119414. Epub 2021 Mar 24. PMID: 33774032

Article Published Date : Jun 14, 2021

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Apoptotic, Autophagy Inhibitors, Cardioprotective

[+]

Astragaloside IV: A promising natural neuroprotective agent for neurological disorders.Feb 28, 2023

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Pubmed Data : Front Pharmacol. 2018 ;9:496. Epub 2018 May 22. PMID: 29872394

Pubmed Data : Nutr J. 2008;7:11. Epub 2008 Apr 21. PMID: 11189248

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Astragalus

Diseases : Hypertrophy: Right Ventricular, Pulmonary Hypertension

[+]

Astragalus contains a compound called astragaloside IV which improves homocysteine-induced acute phase endothelial dysfunction via antioxidation.Jan 01, 2010

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Pubmed Data : Biol Pharm Bull. 2010;33(4):641-6. PMID: 20410599

Article Published Date : Jan 01, 2010

[+]

Astragalus membranaceus and Salvia miltiorrhiza ameliorate hypertensive renal damage.Dec 31, 2021

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Pubmed Data : J Ethnopharmacol. 2024 Jul 9:118554. Epub 2024 Jul 9. PMID: 38992398

Article Published Date : Jul 08, 2024

Study Type : Animal Study

Additional Links

Substances : Astragalus

Diseases : Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Astragalus mongholicus polysaccharides ameliorate hepatic lipid accumulation and inflammation as well as modulate gut microbiota in NAFLD.Jun 20, 2022

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Pubmed Data : Food Funct. 2022 Jun 21. Epub 2022 Jun 21. PMID: 35726797

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Pubmed Data : Lipids Health Dis. 2023 Jan 21 ;22(1):9. Epub 2023 Jan 21. PMID: 36670439

Article Published Date : Jan 20, 2023

Study Type : Animal Study

Additional Links

Substances : Astragalus

Diseases : Cachexia, Heart Failure, Inflammation, Obesity

Additional Keywords : Polysaccharides

[+]

Astragalus polysaccharide protects sepsis model rats after cecum ligation and puncture.Dec 31, 2021

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Pubmed Data : Front Pharmacol. 2022 ;13:1103557. Epub 2023 Jan 9. PMID: 36699092

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Astragalus

Diseases : Myocardial Ischemia

Pharmacological Actions : Angiogenesis Inducing Agents, Cardioprotective

[+]

Astragalus saponins and glycyrrhizic acid synergistically alleviated hepatic fibrosis.Jun 05, 2016

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Pubmed Data : J Ethnopharmacol. 2016 Jun 6 ;190:83-90. Epub 2016 Jun 6. PMID: 27282665

Article Published Date : Jun 05, 2016

Study Type : Animal Study

Additional Links

Substances : Astragalus, Licorice

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective

Additional Keywords : Natural Substance Synergy

[+]

Astragalus saponins and its main constituents ameliorate ductular reaction and liver fibrosis.Dec 31, 2021

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Pubmed Data : Am J Chin Med. 2015 ;43(7):1419-38. Epub 2015 Oct 18. PMID: 26477799

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Astragalus, Ginsenosides, Panax Notoginseng

Diseases : Brain Ischemia, Inflammation

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Phytotherapy

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Compounds found within Astragalus elevate circulating adiponectin levels resulting in the amelioration of insulin resistance and glucose intolerance in obese mice. Feb 01, 2009

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Pubmed Data : Endocrinology. 2009 Feb;150(2):625-33. Epub 2008 Oct 16. PMID: 18927219

Article Published Date : Feb 01, 2009

Study Type : Animal Study

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Substances : Astragalus

Diseases : Adiponectin: Low Levels, Insulin Resistance, Obesity

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Compounds in Astragalus protect against homocysteine-induced injury to the lining of the arteries.Apr 01, 2007

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Pubmed Data : Vascul Pharmacol. 2007 Apr;46(4):278-85. Epub 2006 Nov 10. PMID: 17196887

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Feb 23 ;14(5). Epub 2022 Feb 23. PMID: 35267929

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:5070415. Epub 2020 Sep 14. PMID: 33014270

Article Published Date : Dec 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Endothelial Dysfunction

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

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View the Evidence: 577 Abstracts with Astragalus Research

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Effect of Astragaloside IV on improving cardiac function in rats with heart failure.Dec 31, 2022

Astragaloside IV exerted potential cardioprotective function in acute myocardial ischemia/reperfusion injury.Dec 31, 2017

Astragaloside IV exerts cardioprotection in animal models of viral myocarditis.Dec 31, 2018

Astragaloside IV exerts renal protective effects in animals with diabetes mellitus through multiple signalling pathways.Sep 14, 2020

Effectiveness of medicinal plants for glycaemic control in type 2 diabetes.Dec 31, 2020

Evaluation of astragaloside IV in hepatic fibrosis: A meta-analysis. Apr 01, 2021

Specific combinations of traditional medicines appeared to produce higher contributions to tumor response rate than the TMs individually.Aug 05, 2015

These findings suggest that astragaloside IV is a multifaceted renoprotective candidate drug for diabetic nephropathy.Dec 31, 2019

A 30% ethanol extract of Astragalus membranaceus and Salvia miltiorrhiza, for alleviating fatigue in long COVID.Dec 31, 2023

An herbal decoction that includes Astragalus shows potential for management of cancer-related anorexia.Feb 11, 2010

Astragalosides supplementation enhances intrinsic muscle repair capacity following eccentric exercise-induced injury.Oct 16, 2022

Astragalus combined with chemotherapy can significantly improve the quality of life and the mean survival time in non-small cell lung cancer patients.Oct 01, 2003

Astragalus has a diuretic/natruiretic effect.Mar 28, 2008

Astragalus has a positive immunomodulatory effect in patients with myasthenia gravia. Apr 01, 2009

Astragalus has a significant effect on improving heart function in patients with congestive heart failure.Oct 01, 2001

Astragalus improves cardiac function in aged patients with Chronic Heart Failure.Sep 01, 2005

Astragalus improves cell immunity in viral myocarditis.Jun 01, 1995

Astragalus improves immune function in Herpes Simplex Keratitis.Jun 01, 2007

Astragalus increases the dentritic cell induction of Peripheral Mononuclearcells in Acute LeukemiaOct 01, 2005

Astragalus injection may be a useful approach for enhancing the efficacy of system lupus erythematoosus treatment. May 01, 2006

Astragalus may be an effective treatment against leukopenia. Aug 01, 1995

Astragalus may have a therapeutic effect in modulating immune function in children with recurrent tonsilitis.Jun 01, 1999

Astragalus may provide an ideal complementary treatment to chemotherapy.Mar 01, 2008

Astragalus may significantly improve Chronic Aplastic Anemia via recovery of hemopoietic function.May 01, 2004

Astralagus and Red Sage (Salvia miltiorrhiza) significantly decreased fatigue in Chronic Fatigue Syndrome. Jun 01, 2009

Astralagus may provide a safe and effective treatment ofr idiopathic membranous nephropathy. Dec 01, 2007

D-mannose-based dietary supplement to placebo for the treatment of uncomplicated Escherichia coli urinary tract infections.Jun 30, 2023

TA-65 improved key markers of cardiovascular disease risk.Dec 31, 2017

The new Chinese herbal preparation, Man-Shen-Ling (consisting of medicinal herbs such as Astragalus and Rehmannia) is safe and effective in treating chronic nephritis. May 01, 1993

Angelica and Astragalus could protect against oxidative stress-induced apoptosis in kidney epithelium.Feb 16, 2016

Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes.Jun 30, 2017

Astragaloside potentially serve as a promising and effective therapeutic agent for treating osteoarthritis patients.Jul 31, 2019

Astragalus polysaccharides inhibits ovarian cancer cell growth via microRNA-27a/FBXW7 signaling pathway.Mar 11, 2020

Radix astragalus isoflavones exhibit osteogenic activity.Jan 01, 2018

Selenized astragalus polysaccharide may be a candidate drug for the treatment and prevention of kidney stones.May 01, 2020

Astragaloside IV alleviates podocyte injury in diabetic nephropathy.Jul 22, 2024

Astragaloside IV ameliorates peritoneal fibrosis.Jul 25, 2023

Astragaloside IV attenuates high-glucose-induced impairment in diabetic nephropathy.Dec 31, 2022

Astragaloside IV attenuates neuroinflammation and ameliorates cognitive impairment in Alzheimer's disease.Jan 31, 2023

Astragaloside IV enhances the sensitivity of breast cancer stem cells to paclitaxel by inhibiting stemness.Dec 30, 2023

Astragaloside IV improves slow transit constipation by regulating gut microbiota and enterochromaffin cells.Dec 31, 2022

Astragaloside IV in hypoxic pulmonary hypertension.Aug 01, 2022

Astragaloside IV induces the protective effect of bone marrow mesenchymal stem cells derived exosomes in acute myocardial infarction.Mar 26, 2023

Astragaloside IV protects against lung injury and pulmonary fibrosis in COPD.Sep 07, 2023

Astragaloside IV protects renal tubular epithelial cells against oxidative stress-induced injury.Jul 21, 2024

Astragaloside IV targeting autophagy of T cells improves inflammation of asthma.Jan 10, 2024

The role of macrophage-derived Exosomes in reversing peritoneal fibrosis: Insights from Astragaloside IV.Apr 24, 2024

These findings suggest that astragaloside might treat pulmonary fibrosis.Sep 30, 2022

Astragaloside protects rat brain from microwave-induced functional injuries via restoring acetylcholine and normalizing electroencephalogram.Jul 15, 2020

A combination of Astagalus, Rhodiola Rosea and Sophora flavenscens ameliorates coxsackievirus B3 induced myocarditis in mice. Dec 01, 2007

A herbal decoction of astragalus and angelica promotes thrombopoiesis in the mouse model. Jul 06, 2009

Aastragaloside IV can alleviate inflammation and enhance immunity in rats with experimental periodontitis.Apr 24, 2019

Administration of astragaloside containing fluid led to a dramatic improvement in survival following crush syndrome.Sep 03, 2017

Alleviative effects of astragaloside IV on cyclophosphamide-induced oxidative damage and immunosuppression.Nov 07, 2022

Amelioratory effects of astragaloside IV on hepatocarcinogenesis.Jul 31, 2023

Angiogenic function of astragaloside IV in rats with myocardial infarction occurs via the PKD1-HDAC5-VEGF pathway.Mar 31, 2019

Anti-anxiety and antidepressant-like effects of astragaloside IV and saponins extracted from Astragalus spinosus.Mar 04, 2021

Anti-inflammatory effects of a novel herbal extract in the muscle and spinal cord of an Amyotrophic lateral sclerosis.Dec 31, 2020

Antihypertension effect of astragaloside IV during cerebral ischemia reperfusion.Dec 31, 2022

Antioxidative effect of astragalosides on acute pancreatitis.Dec 31, 2023

AS IV is able to protect developing brain from anesthesia-induced neuroapoptosisAug 31, 2016

Astragaloside -IV prevents dopaminergic neurodegeneration in Parkinson's disease.Apr 05, 2020

Astragaloside A protects against photoreceptor degeneration.Dec 31, 2021

Astragaloside alleviates alcoholic fatty liver disease by suppressing oxidative stress.May 10, 2021

Astragaloside attenuated cisplatin-mediated renal injury.Jun 30, 2017

Astragaloside attenuates myocardial injury.May 31, 2017

Astragaloside could efficiently improve lipid metabolism in obese mice.Jul 21, 2016

Astragaloside exerts its protective effect against sepsis-induced acute lung injury in rats.Apr 30, 2016

Astragaloside has potential in reversing intestinal metaplasia and dysplasia of gastric precancerous lesions and protecting the gastric mucosa.Jul 31, 2018

Astragaloside II alleviates the symptoms of experimental ulcerative colitis in vitro and in vivo.Dec 31, 2018

Astragaloside II ameliorated podocyte injury and mitochondrial dysfunction in streptozotocin-induced diabetic rats.Dec 31, 2020

Astragaloside II promotes intestinal epithelial repair.Sep 25, 2017

Astragalus

View the Evidence:
577 Abstracts with Astragalus Research