Bacopa

Name	AC	CK
Cognitive Decline/Dysfunction	22	97
Alzheimer's Disease	33	52
Attention Deficit Hyperactivity Disorder	2	30
Oxidative Stress	13	30
Aging: Brain	6	26
Memory Disorders	10	25
Parkinson's Disease	12	25
Neurodegenerative Diseases	15	20
Depression	10	17
Brain: Oxidative Stress	6	16
Schizophrenia	8	13
Learning disorders	2	12
Aging	1	10
Sleep Disorders	1	10
Aluminum Toxicity	4	8
Lipid Peroxidation	4	8
Anxiety	4	7
Brain Inflammation	6	7
Dementia	4	7
Epilepsy	5	7
Pesticide Toxicity	4	7
Chronic Pain	3	6
Memory Loss	3	6
Breast Cancer	4	5
Diabetes Mellitus: Type 2	3	5
Hyperglycemia	3	5
Inflammation	4	5
Amnesia	2	4
Amnesia: Drug-Induced	2	4
Chemotherapy-Induced Toxicity: Cisplatin	2	4
Diabetic Nephropathy	2	4
Hepatic Encephalopathy	2	4
Liver Damage: Drug-Induced	2	4
Myocardial Infarction	2	4
Skin Cancer	2	4
Stress	2	4
Autism Spectrum Disorders	2	3
Breast Cancer: Triple Negative	3	3
Cerebral Ischemia	2	3
Colon Cancer	2	3
Hydrogen Peroxide Induced Toxicity	3	3
Infertility: Male	2	3
Advanced Glycation End products (AGE)	1	2
Aflatoxicosis	1	2
Alcohol Withdrawal	1	2
Allodynia	1	2
Amyloidosis	1	2
Brain Hypoxia	1	2
Cancers: All	2	2
Central Nervous System Diseases	2	2
Cervical Cancer	1	2
Childhood Stress	1	2
Duchenne's Muscular Dystrophy	1	2
Emesis	1	2
Glioblastoma	2	2
Heart Failure	1	2
Hyperalgesia	1	2
Hypercholesterolemia	1	2
Hypertension	1	2
Hypertension: Pulmonary	1	2
Hypothyroidism	1	2
Hypoxia: Brain	1	2
Kidney Damage: Drug-Induced	1	2
Lead Poisoning	1	2
Liver Cancer	2	2
Liver Damage: Aflatoxin-Induced	1	2
Liver Failure: Acute	1	2
Lung Cancer	1	2
Memory Disorders: Drug-Induced	1	2
Neuropathic Pain	1	2
Parkinsonian Disorders	1	2
Psychiatric Disorders	1	2
Psychoses	1	2
Stroke	2	2
Arthritis	1	1
Benzo[a]pyrene-induced Toxicity	1	1
Brain Damage	1	1
Cancers: Drug Resistant	1	1
Colorectal Cancer	1	1
Diabetes: Cognitive Dysfunction	1	1
Fungus Diseases	1	1
Glioma	1	1
Huntington Disease	1	1
Intima Media Thickening	1	1
Mitochondrial Dysfunction	1	1
Neuroblastoma	1	1
Obesity	1	1
Oral Cancer	1	1
Pseudomonas aeruginosa	1	1
Rheumatoid Arthritis	1	1
Squamous cell carcinoma	1	1
Staphylococcus aureus infection	1	1
Tumors	1	1
Wound Healing	1	1

Name	AC	CK
Neuroprotective Agents	84	193
Antioxidants	45	87
Superoxide Dismutase Up-regulation	7	21
Anti-Inflammatory Agents	15	17
Antidepressive Agents	9	16
Catalase Up-Regulation	3	13
Apoptotic	11	12
Neurogenesis	6	11
Antiproliferative	10	10
Antinoceceptive	4	8
Renoprotective	4	8
Tumor Necrosis Factor (TNF) Alpha Inhibitor	6	8
Anti-Apoptotic	7	7
Anticonvulsants	4	6
Hepatoprotective	3	6
Hypoglycemic Agents	3	6
Anti-Anxiety Agents	3	5
Nootropic Agents	4	5
Chemopreventive	2	4
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	4
Interleukin-6 Downregulation	3	4
Tumor Suppressor Protein p53 Upregulation	2	4
Anti-metastatic	3	3
Brain-derived neurotrophic factor modulator	2	3
Cell cycle arrest	3	3
Cytoprotective	3	3
Fertility Agents: Male	2	3
Glutathione Upregulation	2	3
Hypolipidemic	2	3
Malondialdehyde Down-regulation	2	3
Nrf2 activation	2	3
Anti-Angiogenic	2	2
Anti-Fibrotic	1	2
Anti-Glycation Agents	1	2
Antioxidant Effects	1	2
Antipsychotic Agents	1	2
Autophagy Up-regulation	2	2
Cardioprotective	1	2
Chemoprotective Agents	1	2
Chemotherapeutic	1	2
Cholinesterase Inhibitors	1	2
Cyclooxygenase Inhibitors	1	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Heme oxygenase-1 up-regulation	1	2
Lipoxygenase Inhibitors	1	2
NF-kappa-B-inducing kinase (NIK) modulator	1	2
Neuroplasticity enhancement	1	2
Neurorestorative	1	2
Vascular Cell Adhesion Molecule-1 Inhibitor	1	2
Vascular Endothelial Growth Factor A Inhibitor	1	2
Acetylcholinesterase Down-Regulation	1	1
Acetylcholinesterase Inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Anti-Tumor	1	1
Antifungal Agents	1	1
Antimicrobial	1	1
Cyclooxygenase 2 Inhibitors	1	1
Enzyme Inhibitors	1	1
Immunomodulatory	1	1
Interferon Gamma Reducer	1	1
Nitric Oxide Inhibitor	1	1

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Pubmed Data : Phytother Res. 2022 Feb ;36(2):996-1012. Epub 2022 Jan 18. PMID: 35041248

Article Published Date : Jan 31, 2022

Study Type : Human Study

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Substances : Bacopa

Diseases : Attention Deficit Hyperactivity Disorder

Additional Keywords : Plant Extracts

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Efficacy of Bacopa monnieri and donepezil in Alzheimer's disease and mild cognitive impairment.Oct 31, 2020

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Pubmed Data : BMC Complement Altern Med. 2015 ;15:337. Epub 2015 Sep 25. PMID: 26407565

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Pubmed Data : BMC Complement Altern Med. 2017 Feb 20 ;17(1):117. Epub 2017 Feb 20. PMID: 28219356

Article Published Date : Feb 19, 2017

Study Type : Animal Study

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Substances : Bacopa

Diseases : Myocardial Infarction

Pharmacological Actions : Cardioprotective

Additional Keywords : Phytotherapy, Plant Extracts

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B. monnieri reduces alpha synuclein aggregation, prevents dopaminergic neurodegeneration and restores the lipid content in nematodes.Oct 06, 2011

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Pubmed Data : Biochem Biophys Res Commun. 2011 Oct 7 ;413(4):605-10. Epub 2011 Sep 8. PMID: 21925152

Article Published Date : Oct 06, 2011

Study Type : Transgenic Animal Study

Additional Links

Substances : Bacopa

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts

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B. monnieri treatments could be effective in managing the neurotransmitter balance in the cerebral cortex.Dec 31, 2014

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Pubmed Data : Neurochem Res. 2015 Jan ;40(1):216-25. Epub 2014 Dec 13. PMID: 25503823

Article Published Date : Dec 31, 2014

Pubmed Data : Neurochem Res. 2016 May ;41(5):985-99. Epub 2015 Dec 16. PMID: 26677075

Article Published Date : Apr 30, 2016

Study Type : Animal Study

Additional Links

Substances : Bacopa

Diseases : Cognitive Decline/Dysfunction, Memory Disorders: Drug-Induced

Pharmacological Actions : Antioxidants, Neuroprotective Agents

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Bacopa Monniera extract alleviates depression induced by chronic unpredictable stress.Jun 30, 2014

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Pubmed Data : Metab Brain Dis. 2015 Feb ;30(1):115-27. Epub 2014 Jul 19. PMID: 25037167

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Pubmed Data : J Tradit Complement Med. 2021 Mar ;11(2):137-143. Epub 2020 Mar 4. PMID: 33728274

Article Published Date : Feb 28, 2021

Study Type : Animal Study

Additional Links

Substances : Bacopa

Diseases : Epilepsy

Pharmacological Actions : Anticonvulsants, Neuroprotective Agents

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Bacopa monnieri extract ameliorates chronic unpredictable stress induced behavioural depression in rats.Dec 31, 2016

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Pubmed Data : Psychiatry Investig. 2017 Jan ;14(1):74-80. Epub 2016 Dec 29. PMID: 28096878

Article Published Date : Dec 31, 2016

Study Type : Animal Study

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Substances : Bacopa

Diseases : Depression, Stress

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Plant Extracts

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Bacopa monnieri extract diminish hypoxia-induced anxiety.Jan 23, 2025

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Pubmed Data : Neuromolecular Med. 2025 Jan 24 ;27(1):11. Epub 2025 Jan 24. PMID: 39853472

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Pubmed Data : Biochem Biophys Res Commun. 2017 12 9 ;494(1-2):34-41. Epub 2017 Oct 18. PMID: 29054405

Article Published Date : Jan 08, 2017

Study Type : Animal Study

Additional Links

Substances : Bacopa

Diseases : Infertility: Male, Lipid Peroxidation

Pharmacological Actions : Antioxidants, Fertility Agents: Male

Additional Keywords : Plant Extracts

[+]

Bacopa monnieri may provide a beneficial herbal remedy for the efficient management of opioid related hepatotoxicity and nephrotoxicity.Jan 31, 2016

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Pubmed Data : Heliyon. 2016 Feb ;2(2):e00068. Epub 2016 Feb 15. PMID: 27441247

Article Published Date : Jan 31, 2016

Study Type : Animal Study

Additional Links

Substances : Bacopa

Diseases : Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Morphine

[+]

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Unveiling the intriguing potential of Bacopa monnieri extract in alleviating cypermethrin-induced hypothyroidism.Oct 31, 2025

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Pubmed Data : Toxicol Res. 2025 Nov ;41(6):649-661. Epub 2025 Aug 4. PMID: 41169277

Article Published Date : Oct 31, 2025

Study Type : Animal Study

Additional Links

Substances : Bacopa

Diseases : Hypothyroidism

Pharmacological Actions : Antioxidants

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Bio-Computational Evaluation of Compounds of Bacopa monnieri as a potential treatment for schizophrenia Oct 18, 2022

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Pubmed Data : Molecules. 2022 Oct 19 ;27(20). Epub 2022 Oct 19. PMID: 36296643

Article Published Date : Oct 18, 2022

Study Type : In Vitro Study

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Substances : Bacopa

Diseases : Schizophrenia

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Investigating Bacopa monnieri therapeutic potential for the treatment of neurological diseases.Dec 31, 2023

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Pubmed Data : Curr Pharm Des. 2024 ;30(13):1016-1030. PMID: 38500283

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Pubmed Data : Phytomedicine. 2025 Mar ;138:156444. Epub 2025 Jan 29. PMID: 39892307

Article Published Date : Feb 28, 2025

Study Type : In Vitro Study

Additional Links

Substances : Bacopa

Diseases : Arthritis, Rheumatoid Arthritis

Pharmacological Actions : Antiproliferative , Apoptotic, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Bacopaside II enhances doxorubicin efficacy in triple-negative breast cancer.Jan 02, 2025

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Pubmed Data : Biomed Pharmacother. 2025 Oct ;191:118466. Epub 2025 Aug 14. PMID: 40816035

Article Published Date : Sep 30, 2025

Study Type : Review

Additional Links

Substances : Bacopa

Diseases : Diabetes: Cognitive Dysfunction, Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

Additional Keywords : Plant Extracts

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Bacoside-A might be considered as a potent therapeutic agent for alleviating obesity and hyperlipidemia.Jul 31, 2024

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Pubmed Data : Biotechnol Appl Biochem. 2024 Aug ;71(4):741-752. Epub 2024 Feb 28. PMID: 38419375

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Pubmed Data : Sci Rep. 2020 12 3 ;10(1):21127. Epub 2020 Dec 3. PMID: 33273550

Article Published Date : Jan 02, 2020

Study Type : In Vitro Study

Additional Links

Substances : Bacopa, Bee Propolis

Diseases : Glioblastoma

Pharmacological Actions : Antiproliferative

Additional Keywords : Natural Substance Synergy

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Comparative metabolomics and network pharmacology analysis reveal shared neuroprotective mechanisms of Bacopa monnieri and Centella asiatica.May 29, 2024

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Pubmed Data : Arch Biochem Biophys. 2019 Nov 15 ;676:108153. Epub 2019 Oct 14. PMID: 31622587

Article Published Date : Nov 14, 2019

Study Type : Review

Additional Links

Substances : Bacopa

Diseases : Alzheimer's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

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This review presents the findings on bacosides in therapeutic plants and their impact on Alzheimer disease pathology. Dec 31, 2018

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Pubmed Data : Planta Med. 2015 Nov 6. Epub 2015 Nov 6. PMID: 26544120

Article Published Date : Nov 05, 2015

Study Type : In Vitro Study

Additional Links

Substances : Bacopa

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

[+]

This supports the idea that the cytotoxicity of bac I and II combined is mediated through their action on the plasma membrane.May 05, 2021

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Pubmed Data : Pharmaceuticals (Basel). 2021 May 6 ;14(5). Epub 2021 May 6. PMID: 34066415

Article Published Date : May 05, 2021

Study Type : In Vitro Study

Additional Links

Substances : Bacopa

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

Additional Keywords : Natural Substance Synergy

[+]

Transthyretin anti-amyloidogenic and fibril disrupting activities of Bacopa monnieri extract.Dec 08, 2019

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Pubmed Data : Biomolecules. 2019 Dec 9 ;9(12). Epub 2019 Dec 9. PMID: 31835306

Article Published Date : Dec 08, 2019

Study Type : In Vitro Study

Additional Links

Substances : Bacopa

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

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View the Evidence: 175 Abstracts with Bacopa Research

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Bacopa monnieri has the potential to improve cognition.Dec 31, 2013

A multi-herbal product called Protandim has significant antioxidant properties in human subjects. Jan 01, 2006

Acute effects of combined Bacopa, American ginseng and whole coffee fruit on working memory and cerebral haemodynamic response of the prefrontal cortex.Nov 17, 2019

B. monnieri extract can improve emotional function in Parkinson's disease patients.Jan 31, 2023

Bacopa enhances cognitive performance in the aging.Jul 01, 2008

Bacopa monnieri can improve the cognitive performance overall.Mar 02, 2024

Comparative efficacy of Medhya Rasayana, Bacopa monnieri, and Centella asiatica in enhancing memory and IQ of 8–10 year-old healthy boys: A prakriti-based double-blind, randomized controlled trial.Jul 01, 2025

Effects of Bacopa monnieri in a population of males exhibiting inattention and hyperactivity aged 6 to 14 years.Jan 31, 2022

Efficacy of Bacopa monnieri and donepezil in Alzheimer's disease and mild cognitive impairment.Oct 31, 2020

Improvement of executive function after short-term administration of an antioxidants mix.Dec 26, 2020

This is the first study to test the efficacy of Cognition Support Formula® on cognition in older adults with subjective cognitive impairment.Jun 09, 2019

This study further adds to the increasing scientific evidence supporting cognitive enhancement effects of Bacopa monnieri in humans.Dec 31, 2015

A combination of Bacopa, Amla (E. officinalis), Licorice (G. glabra), Indian mango (M. indica) and Clove (S. aromaticum) protect against experimentally-induced cardiac and renal damage. Mar 01, 2005

A methanolic extract of B. monniera possesses antidepressant-like activity in the animal behavioural models.Dec 31, 2014

A multi-herbal product called Protandim exhibits chemopreventive properties in a mouse model of skin cancer. Jan 01, 2010

A multi-herbal product called Protandim has chemopreventive properties against skin cancer. Jan 01, 2009

A multi-herbal product called Protandim prevents fibrosis and capillary loss and preserves right ventricular function in rats.Nov 17, 2009

A poly-herbal formula named Protandim reduces oxidative stress in a mouse model of Duchenne muscular dystrophy. Jun 01, 2010

Amelioration of amyloid-β induced Alzheimer's disease by Bacopa monnieri.Dec 23, 2023

An extract of B. monniera ameliorated the amnesic effect of scopolamine in mice. Dec 31, 2014

An extract of Bacopa monniera effectively protects the kidney from hypercholesterolemia-mediated oxido-lipidemic damage.Sep 30, 2014

An extract of Bacopa monnieri restored the memory in CoCl2-hypoxia mimetic mice.Dec 31, 2014

Antihyperglycemic activity of bacosine.Apr 30, 2011

Antinociceptive activity of standardized extract of Bacopa monnieri in different pain models of zebrafish.Jan 09, 2022

B. monniera whole-plant extracts can be considered as a possible remedy to counteract aluminum-associated neurological disorders.Oct 30, 2014

B. monnieri and its isolate stigmasterol might inhibit the progression of diabetic nephropathy.Sep 30, 2016

B. monnieri having strong antioxidant activity exerted a protective effect against morphine induced cerebellar toxicity.Oct 31, 2017

B. monnieri improves myocardial function following ischemia and reperfusion injury.Feb 19, 2017

B. monnieri reduces alpha synuclein aggregation, prevents dopaminergic neurodegeneration and restores the lipid content in nematodes.Oct 06, 2011

B. monnieri treatments could be effective in managing the neurotransmitter balance in the cerebral cortex.Dec 31, 2014

Bacopa amelioriates hypoxia-induced cognitive impairment. Apr 01, 2009

Bacopa enhances cognitive function and protects against neurodegeneration in an Alzheimer's disease model. Oct 04, 2009

Bacopa extract reduces brain amyloid levels in mice by as much as 60%. Aug 01, 2006

Bacopa has a neuroprotective effect against rotenone-induced oxidative stress adn neurotoxicity.Nov 01, 2009

Bacopa monieri has great potential for development of anticancer treatments.Sep 30, 2017

Bacopa monnier ameliorated trimethyltin-induced cognitive disturbances.Dec 31, 2018

Bacopa monniera extract administration showed significant protection against scopolamine-induced toxicity.Apr 30, 2016

Bacopa Monniera extract alleviates depression induced by chronic unpredictable stress.Jun 30, 2014

Bacopa monniera extract mitigates isoproterenol-induced cardiac stress.Nov 21, 2019

Bacopa monniera extracts administered orally produce neuroprotective effect in cold stress induced hippocampal neurodegeneration of rats.Dec 31, 2014

Bacopa monniera may have therapeutic value for the treatment of cognitive impairment.Jan 31, 2015

Bacopa monniera possesses antipsychotic properties in animals. Dec 31, 2014

Bacopa monniera silver nanoparticles are able to eradicate the oxidative stress and prevent the tissue damage in aluminum exposed mice.Jan 31, 2015

Bacopa monnieri abrogates alcohol abstinence-induced anxiety-like behaviour.Feb 28, 2019

Bacopa monnieri alleviates aluminium chloride-induced anxiety.Jul 12, 2020

Bacopa monnieri alleviates paraquat induced toxicity in Drosophila.Nov 30, 2018

Bacopa monnieri attenuates glutamate-induced nociception and brain mitochondrial toxicity in Zebrafish.Dec 31, 2021

Bacopa monnieri can be used as adjuvant therapy for neuropathic pain conditions afflicted with allodynia and hyperalgesia.Jun 04, 2017

Bacopa monnieri exhibited anti-seizure activity.Feb 28, 2021

Bacopa monnieri extract ameliorates chronic unpredictable stress induced behavioural depression in rats.Dec 31, 2016

Bacopa monnieri extract diminish hypoxia-induced anxiety.Jan 23, 2025

Bacopa monnieri extract enhances learning-dependent hippocampal long-term synaptic potentiation.Nov 07, 2017

Bacopa monnieri extract exerted neuroprotective effects possibly by promoting hippocampal neurogenesis with elevation of BDNF level.Oct 31, 2016

Bacopa monnieri extract improves memory performance.May 08, 2020

Bacopa monnieri extract prevents the neurochemical alterations associated with hepatic encephalopathy.Dec 31, 2014

Bacopa monnieri extracts have memory enhancing and anti-diabetic properties.Dec 31, 2014

Bacopa monnieri extracts have significant anti-hyperglycemic and anti-nociceptive potential.Oct 31, 2015

Bacopa monnieri has therapeutic potential in the treatment of Alzheimer disease associated cognitive decline.Aug 31, 2012

Bacopa monnieri may be useful alone or in combination with other anti-emetic drugs for the treatment of chemotherapy-induced emesis in man.Mar 31, 2017

Bacopa monnieri may prove useful in improving reproductive health in males.Jan 08, 2017

Bacopa monnieri may provide a beneficial herbal remedy for the efficient management of opioid related hepatotoxicity and nephrotoxicity.Jan 31, 2016

Bacopa monnieri phytochemicals as promising BACE1 inhibitors for Alzheimer's disease therapy.Apr 17, 2025

Bacopa monnieri prevents colchicine-induced dementia by anti-inflammatory action.Jan 01, 2019

Bacopa monnieri supplements offset paraquat-induced behavioural phenotype and brain oxidative pathways in mice.Jan 14, 2019

Bacopa monnieri was beneficial for the prevention of cognitive deficits related to cerebral ischemia.Apr 21, 2015

Bacopa prevents aluminium neurotoxicity in the rat brain. Apr 20, 2007

Bacopa reduces inflammation by positively modulating COX and LOX enzyme pathways and Tumor Necrosis Factor.Jul 23, 2008

Bacopaside I alleviates depressive-like behaviors by modulating the gut microbiome and host metabolism in CUMS-induced mice.Dec 31, 2023

Bacopaside I can reduce the beta amyloid levels in the brains of mice in an Alzheimer's disease model.Mar 01, 2016

Bacopaside I displayed antidepressant-like activity in animals. Oct 31, 2017

Bacopaside-I ameliorates motor dysfunction and neurodegeneration in rat model of Parkinson's disease.Apr 30, 2025

Bacoside-A offers a higher renoprotective effect to counter abnormal parameters of renal function in diabetes-induced renal injury.Oct 31, 2023

Bacopa

View the Evidence:
175 Abstracts with Bacopa Research