Bacopa

Name	AC	CK
Cognitive Decline/Dysfunction	17	65
Oxidative Stress	9	24
Alzheimer's Disease	16	23
Memory Disorders	8	23
Attention Deficit Hyperactivity Disorder	1	20
Aging: Brain	5	16
Neurodegenerative Diseases	10	15
Depression	7	12
Schizophrenia	6	11
Aging	1	10
Aluminum Toxicity	4	8
Parkinson's Disease	5	7
Brain: Oxidative Stress	5	6
Dementia	3	6
Lipid Peroxidation	3	6
Memory Loss	3	6
Pesticide Toxicity	3	6
Amnesia	2	4
Amnesia: Drug-Induced	2	4
Anxiety	2	4
Brain Inflammation	3	4
Breast Cancer	3	4
Chemotherapy-Induced Toxicity: Cisplatin	2	4
Epilepsy	3	4
Hyperglycemia	2	4
Myocardial Infarction	2	4
Skin Cancer	2	4
Stress	2	4
Cerebral Ischemia	2	3
Colon Cancer	2	3
Hydrogen Peroxide Induced Toxicity	3	3
Infertility: Male	2	3
Inflammation	2	3
Advanced Glycation End products (AGE)	1	2
Alcohol Withdrawal	1	2
Allodynia	1	2
Amyloidosis	1	2
Brain Hypoxia	1	2
Breast Cancer: Triple Negative	2	2
Cancers: All	2	2
Central Nervous System Diseases	2	2
Cervical Cancer	1	2
Childhood Stress	1	2
Chronic Pain	1	2
Diabetes Mellitus: Type 2	1	2
Diabetic Nephropathy	1	2
Duchenne's Muscular Dystrophy	1	2
Emesis	1	2
Glioblastoma	2	2
Heart Failure	1	2
Hepatic Encephalopathy	1	2
Hyperalgesia	1	2
Hypercholesterolemia	1	2
Hypertension	1	2
Hypertension: Pulmonary	1	2
Hypoxia: Brain	1	2
Kidney Damage: Drug-Induced	1	2
Learning disorders	1	2
Liver Damage: Drug-Induced	1	2
Liver Failure: Acute	1	2
Lung Cancer	1	2
Memory Disorders: Drug-Induced	1	2
Neuropathic Pain	1	2
Psychiatric Disorders	1	2
Psychoses	1	2
Benzo[a]pyrene-induced Toxicity	1	1
Brain Damage	1	1
Huntington Disease	1	1
Intima Media Thickening	1	1
Mitochondrial Dysfunction	1	1
Neuroblastoma	1	1
Pseudomonas aeruginosa	1	1
Staphylococcus aureus infection	1	1
Stroke	1	1
Tumors	1	1

Name	AC	CK
Neuroprotective Agents	51	107
Antioxidants	29	55
Superoxide Dismutase Up-regulation	6	19
Catalase Up-Regulation	3	13
Antidepressive Agents	7	12
Anti-Inflammatory Agents	8	10
Neurogenesis	4	8
Antiproliferative	6	6
Apoptotic	5	6
Renoprotective	3	6
Tumor Necrosis Factor (TNF) Alpha Inhibitor	4	6
Anti-Anxiety Agents	3	5
Antinoceceptive	2	4
Chemopreventive	2	4
Hypoglycemic Agents	2	4
Tumor Suppressor Protein p53 Upregulation	2	4
Anti-Apoptotic	3	3
Anticonvulsants	2	3
Brain-derived neurotrophic factor modulator	2	3
Cell cycle arrest	3	3
Cytoprotective	3	3
Fertility Agents: Male	2	3
Interleukin-6 Downregulation	2	3
Anti-Angiogenic	2	2
Anti-Fibrotic	1	2
Anti-Glycation Agents	1	2
Anti-metastatic	2	2
Antioxidant Effects	1	2
Antipsychotic Agents	1	2
Cardioprotective	1	2
Chemoprotective Agents	1	2
Chemotherapeutic	1	2
Cholinesterase Inhibitors	1	2
Cyclooxygenase Inhibitors	1	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Glutathione Upregulation	1	2
Heme oxygenase-1 up-regulation	1	2
Hepatoprotective	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	2
Lipoxygenase Inhibitors	1	2
Malondialdehyde Down-regulation	1	2
NF-kappa-B-inducing kinase (NIK) modulator	1	2
Neuroplasticity enhancement	1	2
Neurorestorative	1	2
Nrf2 activation	1	2
Vascular Cell Adhesion Molecule-1 Inhibitor	1	2
Vascular Endothelial Growth Factor A Inhibitor	1	2
Acetylcholinesterase Inhibitor	1	1
Anti-Tumor	1	1
Antimicrobial	1	1
Autophagy Up-regulation	1	1
Enzyme Inhibitors	1	1
Interferon Gamma Reducer	1	1
Nitric Oxide Inhibitor	1	1
Nootropic Agents	1	1

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Natural Substances Versus Drugs

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Improvement of executive function after short-term administration of an antioxidants mix.Dec 26, 2020

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Pubmed Data : Nutrients. 2020 Dec 27 ;13(1). Epub 2020 Dec 27. PMID: 33375429

Article Published Date : Dec 26, 2020

Study Type : Human Study

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Substances : Astaxanthin, Bacopa, Lycopene, Vitamin B-12

Diseases : Aging: Brain , Brain: Oxidative Stress, Cognitive Decline/Dysfunction

Pharmacological Actions : Antioxidants, Neuroprotective Agents

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This is the first study to test the efficacy of Cognition Support Formula® on cognition in older adults with subjective cognitive impairment.Jun 09, 2019

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Pubmed Data : BMC Complement Altern Med. 2015 ;15:337. Epub 2015 Sep 25. PMID: 26407565

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Pubmed Data : BMC Complement Altern Med. 2017 Feb 20 ;17(1):117. Epub 2017 Feb 20. PMID: 28219356

Article Published Date : Feb 19, 2017

Study Type : Animal Study

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Substances : Bacopa

Diseases : Myocardial Infarction

Pharmacological Actions : Cardioprotective

Additional Keywords : Phytotherapy, Plant Extracts

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B. monnieri reduces alpha synuclein aggregation, prevents dopaminergic neurodegeneration and restores the lipid content in nematodes.Oct 06, 2011

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Pubmed Data : Biochem Biophys Res Commun. 2011 Oct 7 ;413(4):605-10. Epub 2011 Sep 8. PMID: 21925152

Article Published Date : Oct 06, 2011

Study Type : Transgenic Animal Study

Additional Links

Substances : Bacopa

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts

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B. monnieri treatments could be effective in managing the neurotransmitter balance in the cerebral cortex.Dec 31, 2014

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Pubmed Data : Neurochem Res. 2015 Jan ;40(1):216-25. Epub 2014 Dec 13. PMID: 25503823

Article Published Date : Dec 31, 2014

Pubmed Data : Neurochem Res. 2016 May ;41(5):985-99. Epub 2015 Dec 16. PMID: 26677075

Article Published Date : Apr 30, 2016

Study Type : Animal Study

Additional Links

Substances : Bacopa

Diseases : Cognitive Decline/Dysfunction, Memory Disorders: Drug-Induced

Pharmacological Actions : Antioxidants, Neuroprotective Agents

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Bacopa Monniera extract alleviates depression induced by chronic unpredictable stress.Jun 30, 2014

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Pubmed Data : Metab Brain Dis. 2015 Feb ;30(1):115-27. Epub 2014 Jul 19. PMID: 25037167

Bacopa monnieri extracts have memory enhancing and anti-diabetic properties.Dec 31, 2014

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Pubmed Data : J Ethnopharmacol. 2015 Apr 22 ;164:37-45. Epub 2015 Feb 7. PMID: 25660331

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Pubmed Data : Int Immunopharmacol. 2013 Feb ;15(2):260-74. Epub 2012 Dec 17. PMID: 23257614

Article Published Date : Jan 31, 2013

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Bacopa

Diseases : Aging: Brain , Neurodegenerative Diseases

Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Neuroprotective Agents

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Brahmi is a potential cognitive enhancer against schizophrenia.Feb 28, 2015

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Pubmed Data : J Med Assoc Thai. 2015 Mar ;98 Suppl 2:S56-63. PMID: 26211105

Article Published Date : Feb 28, 2015

Study Type : Animal Study

Additional Links

Substances : Bacopa

Diseases : Schizophrenia

Pharmacological Actions : Neurogenesis, Neuroprotective Agents

Additional Keywords : Plant Extracts

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Brahmi promises to be a novel agent in Alzheimer's disease.Apr 30, 2017

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Pubmed Data : J Histotechnol. 2019 09 ;42(3):128-136. Epub 2019 Aug 4. PMID: 31379302

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Bacopa, Silibinin

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Isoniazid

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The inhibitory effects of B. monniera and its constituents on pancreatic lipase activity and plasma triglyceride level are reported for the first time.Nov 30, 2016

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Pubmed Data : Nat Prod Commun. 2016 Dec ;11(12):1855-1858. PMID: 30508350

Article Published Date : Nov 30, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Bacopa, Caffeic Acid

Pharmacological Actions : Enzyme Inhibitors: Pancreatic Lipase

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This study provides the evidence for the mechanism underlying role of the Bacopa monnieri extract (CDRI-08) in restoring spatial memory in amnesic miceDec 31, 2014

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Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:254303. Epub 2015 Aug 27. PMID: 26413117

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Bacopa

Diseases : Amnesia, Memory Loss

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Gene Expression Regulation, Plant Extracts

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Bio-Computational Evaluation of Compounds of Bacopa monnieri as a potential treatment for schizophrenia Oct 18, 2022

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Pubmed Data : Molecules. 2022 Oct 19 ;27(20). Epub 2022 Oct 19. PMID: 36296643

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Pubmed Data : Cytotechnology. 2016 Jan ;68(1):157-72. Epub 2014 Jul 26. PMID: 25062987

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Bacopa

Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress

Pharmacological Actions : Cytoprotective

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Bacopa monnieri and their bioactive compounds inferred multi-target treatment strategy for neurological diseases.Apr 01, 2020

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Pubmed Data : Biomolecules. 2020 Apr 2 ;10(4). Epub 2020 Apr 2. PMID: 32252235

Article Published Date : Apr 01, 2020

Study Type : In Vitro Study

Additional Links

Substances : Bacopa

Diseases : Alzheimer's Disease, Neurodegenerative Diseases

Pharmacological Actions : Neuroprotective Agents

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Pubmed Data : Molecules. 2019 Sep 30 ;24(19). Epub 2019 Sep 30. PMID: 31574930

Article Published Date : Sep 29, 2019

Study Type : In Vitro Study

Additional Links

Substances : Bacopa

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Natural Substance Synergy

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Pubmed Data : Crit Rev Food Sci Nutr. 2022 Jan 3:1-25. Epub 2022 Jan 3. PMID: 34978226

Article Published Date : Jan 02, 2022

Study Type : Review

Additional Links

Substances : Ashwagandha, Bacopa, Caffeine, Ginkgo biloba

Diseases : Alzheimer's Disease, Anxiety, Dementia, Parkinson's Disease

Pharmacological Actions : Nootropic Agents

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Plantainoside B in Bacopa monniera binds to Aβ aggregates attenuating neuronal damage and memory deficits.Dec 31, 2022

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Pubmed Data : Front Pharmacol. 2016 ;7:44. Epub 2016 Mar 4. PMID: 26973531

Article Published Date : Dec 31, 2015

Study Type : Review

Additional Links

Substances : Bacopa

Diseases : Alzheimer's Disease, Depression, Parkinson's Disease, Schizophrenia, Stroke

Pharmacological Actions : Anti-Anxiety Agents, Anti-Inflammatory Agents, Anticonvulsants, Antidepressive Agents, Antioxidants, Cytoprotective, Neuroprotective Agents

Additional Keywords : Risk Reduction

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This review presents the findings on bacosides in therapeutic plants and their impact on Alzheimer disease pathology. Dec 31, 2018

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Pubmed Data : Planta Med. 2015 Nov 6. Epub 2015 Nov 6. PMID: 26544120

Article Published Date : Nov 05, 2015

Study Type : In Vitro Study

Additional Links

Substances : Bacopa

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

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This supports the idea that the cytotoxicity of bac I and II combined is mediated through their action on the plasma membrane.May 05, 2021

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Pubmed Data : Pharmaceuticals (Basel). 2021 May 6 ;14(5). Epub 2021 May 6. PMID: 34066415

Article Published Date : May 05, 2021

Study Type : In Vitro Study

Additional Links

Substances : Bacopa

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

Additional Keywords : Natural Substance Synergy

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Transthyretin anti-amyloidogenic and fibril disrupting activities of Bacopa monnieri extract.Dec 08, 2019

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Pubmed Data : Biomolecules. 2019 Dec 9 ;9(12). Epub 2019 Dec 9. PMID: 31835306

Article Published Date : Dec 08, 2019

Study Type : In Vitro Study

Additional Links

Substances : Bacopa

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

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View the Evidence: 140 Abstracts with Bacopa Research

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Bacopa monnieri has the potential to improve cognition.Dec 31, 2013

A multi-herbal product called Protandim has significant antioxidant properties in human subjects. Jan 01, 2006

Acute effects of combined Bacopa, American ginseng and whole coffee fruit on working memory and cerebral haemodynamic response of the prefrontal cortex.Nov 17, 2019

B. monnieri extract can improve emotional function in Parkinson's disease patients.Jan 31, 2023

Bacopa enhances cognitive performance in the aging.Jul 01, 2008

Effects of Bacopa monnieri in a population of males exhibiting inattention and hyperactivity aged 6 to 14 years.Jan 31, 2022

Efficacy of Bacopa monnieri and donepezil in Alzheimer's disease and mild cognitive impairment.Oct 31, 2020

Improvement of executive function after short-term administration of an antioxidants mix.Dec 26, 2020

This is the first study to test the efficacy of Cognition Support Formula® on cognition in older adults with subjective cognitive impairment.Jun 09, 2019

This study further adds to the increasing scientific evidence supporting cognitive enhancement effects of Bacopa monnieri in humans.Dec 31, 2015

A combination of Bacopa, Amla (E. officinalis), Licorice (G. glabra), Indian mango (M. indica) and Clove (S. aromaticum) protect against experimentally-induced cardiac and renal damage. Mar 01, 2005

A methanolic extract of B. monniera possesses antidepressant-like activity in the animal behavioural models.Dec 31, 2014

A multi-herbal product called Protandim exhibits chemopreventive properties in a mouse model of skin cancer. Jan 01, 2010

A multi-herbal product called Protandim has chemopreventive properties against skin cancer. Jan 01, 2009

A multi-herbal product called Protandim prevents fibrosis and capillary loss and preserves right ventricular function in rats.Nov 17, 2009

A poly-herbal formula named Protandim reduces oxidative stress in a mouse model of Duchenne muscular dystrophy. Jun 01, 2010

An extract of B. monniera ameliorated the amnesic effect of scopolamine in mice. Dec 31, 2014

An extract of Bacopa monniera effectively protects the kidney from hypercholesterolemia-mediated oxido-lipidemic damage.Sep 30, 2014

An extract of Bacopa monnieri restored the memory in CoCl2-hypoxia mimetic mice.Dec 31, 2014

Antihyperglycemic activity of bacosine.Apr 30, 2011

Antinociceptive activity of standardized extract of Bacopa monnieri in different pain models of zebrafish.Jan 09, 2022

B. monniera whole-plant extracts can be considered as a possible remedy to counteract aluminum-associated neurological disorders.Oct 30, 2014

B. monnieri and its isolate stigmasterol might inhibit the progression of diabetic nephropathy.Sep 30, 2016

B. monnieri having strong antioxidant activity exerted a protective effect against morphine induced cerebellar toxicity.Oct 31, 2017

B. monnieri improves myocardial function following ischemia and reperfusion injury.Feb 19, 2017

B. monnieri reduces alpha synuclein aggregation, prevents dopaminergic neurodegeneration and restores the lipid content in nematodes.Oct 06, 2011

B. monnieri treatments could be effective in managing the neurotransmitter balance in the cerebral cortex.Dec 31, 2014

Bacopa amelioriates hypoxia-induced cognitive impairment. Apr 01, 2009

Bacopa enhances cognitive function and protects against neurodegeneration in an Alzheimer's disease model. Oct 04, 2009

Bacopa extract reduces brain amyloid levels in mice by as much as 60%. Aug 01, 2006

Bacopa has a neuroprotective effect against rotenone-induced oxidative stress adn neurotoxicity.Nov 01, 2009

Bacopa monieri has great potential for development of anticancer treatments.Sep 30, 2017

Bacopa monnier ameliorated trimethyltin-induced cognitive disturbances.Dec 31, 2018

Bacopa monniera extract administration showed significant protection against scopolamine-induced toxicity.Apr 30, 2016

Bacopa Monniera extract alleviates depression induced by chronic unpredictable stress.Jun 30, 2014

Bacopa monniera extract mitigates isoproterenol-induced cardiac stress.Nov 21, 2019

Bacopa monniera extracts administered orally produce neuroprotective effect in cold stress induced hippocampal neurodegeneration of rats.Dec 31, 2014

Bacopa monniera may have therapeutic value for the treatment of cognitive impairment.Jan 31, 2015

Bacopa monniera possesses antipsychotic properties in animals. Dec 31, 2014

Bacopa monniera silver nanoparticles are able to eradicate the oxidative stress and prevent the tissue damage in aluminum exposed mice.Jan 31, 2015

Bacopa monnieri abrogates alcohol abstinence-induced anxiety-like behaviour.Feb 28, 2019

Bacopa monnieri alleviates aluminium chloride-induced anxiety.Jul 12, 2020

Bacopa monnieri alleviates paraquat induced toxicity in Drosophila.Nov 30, 2018

Bacopa monnieri attenuates glutamate-induced nociception and brain mitochondrial toxicity in Zebrafish.Dec 31, 2021

Bacopa monnieri can be used as adjuvant therapy for neuropathic pain conditions afflicted with allodynia and hyperalgesia.Jun 04, 2017

Bacopa monnieri exhibited anti-seizure activity.Feb 28, 2021

Bacopa monnieri extract ameliorates chronic unpredictable stress induced behavioural depression in rats.Dec 31, 2016

Bacopa monnieri extract enhances learning-dependent hippocampal long-term synaptic potentiation.Nov 07, 2017

Bacopa monnieri extract exerted neuroprotective effects possibly by promoting hippocampal neurogenesis with elevation of BDNF level.Oct 31, 2016

Bacopa monnieri extract improves memory performance.May 08, 2020

Bacopa monnieri extract prevents the neurochemical alterations associated with hepatic encephalopathy.Dec 31, 2014

Bacopa monnieri extracts have memory enhancing and anti-diabetic properties.Dec 31, 2014

Bacopa monnieri extracts have significant anti-hyperglycemic and anti-nociceptive potential.Oct 31, 2015

Bacopa monnieri has therapeutic potential in the treatment of Alzheimer disease associated cognitive decline.Aug 31, 2012

Bacopa monnieri may be useful alone or in combination with other anti-emetic drugs for the treatment of chemotherapy-induced emesis in man.Mar 31, 2017

Bacopa monnieri may prove useful in improving reproductive health in males.Jan 08, 2017

Bacopa monnieri may provide a beneficial herbal remedy for the efficient management of opioid related hepatotoxicity and nephrotoxicity.Jan 31, 2016

Bacopa monnieri prevents colchicine-induced dementia by anti-inflammatory action.Jan 01, 2019

Bacopa monnieri supplements offset paraquat-induced behavioural phenotype and brain oxidative pathways in mice.Jan 14, 2019

Bacopa monnieri was beneficial for the prevention of cognitive deficits related to cerebral ischemia.Apr 21, 2015

Bacopa prevents aluminium neurotoxicity in the rat brain. Apr 20, 2007

Bacopa reduces inflammation by positively modulating COX and LOX enzyme pathways and Tumor Necrosis Factor.Jul 23, 2008

Bacopaside I can reduce the beta amyloid levels in the brains of mice in an Alzheimer's disease model.Mar 01, 2016

Bacopaside I displayed antidepressant-like activity in animals. Oct 31, 2017

Bacosides encapsulated in lactoferrin conjugated PEG-PLA-PCL-OH based polymersomes act as epigenetic modulator in chemically induced amnesia.Mar 31, 2020

Brahmi could be a new frontier of restoration and prevention of cognitive deficit in schizophrenia.Nov 30, 2016

Brahmi could be a new frontier of restoration and prevention of cognitive deficit in schizophrenia.Mar 31, 2015

Brahmi could be a novel neuroprotective agent for the prevention of cognitive deficit in schizophrenia.Jul 31, 2014

Brahmi exerts distinct age-related effects on the cell-mediated immune responses through selective modulation of antioxidant enzyme activities.Jan 31, 2013

Brahmi is a potential cognitive enhancer against schizophrenia.Feb 28, 2015

Brahmi promises to be a novel agent in Alzheimer's disease.Apr 30, 2017

Brahmi vati may be used to treat seizures associated with schizophrenia and related memory loss.Feb 28, 2018

Bacopa

View the Evidence:
140 Abstracts with Bacopa Research