Berberine

Name	AC	CK
Insulin Resistance	15	63
Diabetes Mellitus: Type 2	20	55
Hyperlipidemia	8	40
Diabetic Complications	7	22
High Cholesterol	2	22
Hypercholesterolemia	3	22
Triglycerides: Elevated	2	22
Polycystic Ovary Syndrome	2	21
Alzheimer's Disease	13	18
Myocardial Ischemia	6	18
Nonalcoholic fatty liver disease (NAFLD)	9	18
Osteoporosis	6	18
Liver Cancer	14	16
Inflammation	10	15
Metabolic Diseases	4	14
Obesity	10	14
Breast Cancer	12	13
Colon Cancer	9	13
Helicobacter Pylori Infection	3	13
Kidney Diseases	2	12
Cerebral Ischemia	6	11
Lipopolysaccharide-Induced Toxicity	7	11
Atrial Fibrillation	1	10
Depression	5	10
Endothelial Dysfunction	1	10
Oxidative Stress	6	10
Radiation Induced Illness	1	10
Breast Cancer: Triple Negative	7	9
Colorectal Cancer	5	9
Glioblastoma	6	9
High Fat Diet	5	9
Lung Cancer	5	9
Osteosarcoma	4	9
Brain Inflammation	4	8
Cancers: All	8	8
Cognitive Decline/Dysfunction	4	8
Colitis	4	8
Diabetic Nephropathy	4	8
Metabolic Syndrome X	4	8
Diabetes Mellitus: Type 1	4	7
Heart Failure	4	7
Hyperglycemia	4	7
Ischemia	4	7
Pancreatitis	4	7
Atherosclerosis	3	6
Hypoxia	4	6
Gastric Cancer	5	5
Hypertension	3	5
Psoriasis	1	5
Rheumatoid Arthritis	4	5
Acetaminophen (Tylenol) Toxicity	2	4
Advanced Glycation End products (AGE)	3	4
Alcohol Toxicity	2	4
Allergic Rhinitis	2	4
Arthritis	2	4
Autoimmune Diseases	2	4
Cancers: Drug Resistant	4	4
Cardiomyopathy	2	4
Cardiovascular Diseases	4	4
Chemically-Induced Liver Damage	2	4
Chemotherapy-Induced Toxicity: Doxorubicin	2	4
Diabetic Neuropathy	2	4
Enterocolitis: Necrotiziing	2	4
Epilepsy	2	4
Fructose-Induced Toxicity	2	4
Melanoma	4	4
Myocardial Infarction	2	4
Nasopharyngeal Cancer	3	4
Peripheral Neuropathies	2	4
Sepsis	2	4
Traumatic Brain Injury	2	4
Ulcerative Colitis	2	4
Brain Ischemia	2	3
Cancer Metastasis	3	3
Carcinoma: Non-Small-Cell Lung	3	3
Chikungunya Virus	2	3
Diabetes: Oxidative Stress	2	3
Hepatic Steatosis	2	3
Hydrogen Peroxide Induced Toxicity	3	3
Liver Fibrosis	2	3
Neurodegenerative Diseases	2	3
Ovarian Cancer	3	3
Pseudomonas aeruginosa	2	3
Acute Respiratory Distress Syndrome	1	2
Acute T cell Leukemias	2	2
Adenomyosis	2	2
Aging: Brain	1	2
Aluminum Toxicity	1	2
Aneurysm: Cerebral	1	2
Arsenic Poisoning	1	2
Asthma	1	2
Atopic Dermatitis	1	2
Blood-Brain-Barrier Disorders	1	2
Bone Diseases	1	2
Brain Injury: Traumatic	1	2
Breast Cancer: Chemically-Induced	1	2
Bubonic Plague	1	2
Candida Albicans	2	2
Chemotherapy-Induced Toxicity: Paclitaxel	1	2
Cocaine Withdrawal	1	2
Colon Cancer: Prevention	1	2
Colorectal Cancer: Prevention	1	2
Congestive Heart Failure	1	2
Convulsions	1	2
Degenerative Disk Disease	2	2
Dementia	1	2
Demyelinating Diseases	1	2
Diabesity	1	2
Diabetic Neuropathies	1	2
Diabetic Retinopathy	2	2
Diarrhea: Drug-Associated	1	2
Drug-Induced Toxicity: L-Thyroxine	1	2
Drug-Induced Toxicity: Methotrexate	1	2
Endometrial Cancer	1	2
Fatty Liver	1	2
Fibrosis	1	2
Gastric Polyposis	1	2
Glioma	2	2
Heavy Metal Toxicity	1	2
Hepatitis: Autoimmune	1	2
High Homocysteine	1	2
Huntington Disease	1	2
Hyperalgesia	1	2
Hypersensitivity: Type IV	1	2
Hypertension: Pulmonary	1	2
Hypertension: Renal	1	2
Immune Dysregulation: TH1 dominance	1	2
Immune Dysregulation: TH17 over-expression	1	2
Influenza	1	2
Intestinal Permeability	1	2
Intestinal Polyps	1	2
Intima Media Thickening	1	2
Iron Overload	1	2
Irritable Bowel Syndrome	1	2
Kidney Fibrosis	1	2
Lead Poisoning	1	2
Learning disorders	1	2
Leukemia	2	2
Lipid Peroxidation	1	2
Liver Steatosis	1	2
Liver Stress: Fructose-Induced	1	2
Lung Cancer: Prevention	1	2
Mastitis	1	2
Memory Disorders: Drug-Induced	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Miscarriage	1	2
Morphine Tolerance/Dependence	1	2
Multiple Sclerosis	1	2
Myocardial Fibrosis	1	2
Neuroblastoma	2	2
Neuropathic Pain	1	2
Non-Small-Cell Lung Carcinoma	2	2
Pancreatic Cancer	2	2
Parkinson's Disease	1	2
Periodontitis	1	2
Peripheral Nerve Diseases	1	2
Post-Traumatic Stress Disorders (PTSD)	1	2
Postmenopausal Disorders	1	2
Postoperative Recovery	1	2
Prehypertension	1	2
Prostate Cancer	2	2
Prostatic Hyperplasia: Benign	1	2
Retinal Diseases	1	2
Schizophrenia	1	2
Seizures	1	2
Smoking Cessation: Nicotine Addiction	1	2
Staphylococcal Infections	1	2
Staphylococcus aureus: Methicillin-resistant (MRSA)	2	2
Stroke: Ischemic	1	2
Tongue Cancer	1	2
Uremia	1	2
Uveoretinitis	1	2
Varicocele	1	2
Acute Myeloid Leukemia	1	1
Allergic Airway Diseases	1	1
Allergies	1	1
Alphavirus Infections	1	1
Arthritis: Rheumatoid	1	1
Bacillus Cereus infection	1	1
Bacterial Infections and Mycoses	1	1
Breast Cancer Stem Cells	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Cancer: Virus-Induced	1	1
Cancers: Multi-Drug Resistant	1	1
Candida Infection	1	1
Cardiac Arrhythmias	1	1
Cervical Cancer	1	1
Cholangiocarcinoma	1	1
Cholesterol: Oxidation	1	1
Chondrosarcoma	1	1
Clostridium Infections	1	1
Coxsackievirus Infections	1	1
Cytomegalovirus Infections	1	1
Dementia: Senile	1	1
Dental Caries	1	1
Diabetes Mellitus: Type 2: Prevention	1	1
Diabetes: Glycation/A1C	1	1
Diarrhea	1	1
Dyslipidemias	1	1
Echinococcosis	1	1
Enterovirus: Type 71	1	1
Esophageal Cancer	1	1
Eye Diseases	1	1
Friend Virus	1	1
Fungal Infection	1	1
HIV Drug-Induced Toxicity	1	1
HIV Infections	1	1
Head and Neck Cancer	1	1
High Sugar Diet	1	1
Human Papillomavirus (HPV)	1	1
Hydatid Cyst	1	1
Inflammatory Bowel Diseases	1	1
Kidney Damage	1	1
Laryngeal Cancer	1	1
Leaky Gut Syndrome	1	1
Leishmaniasis	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Leukemia: Virus-Induced	1	1
Lower Respiratory Infections	1	1
Lung Injury: Acute	1	1
Lymphangioendothelioma	1	1
Macular Degeneration	1	1
Malignant Melanoma	1	1
Mesothelioma	1	1
Microcystis aeruginosa	1	1
Multiple Myeloma	1	1
Myocarditis: Autoimmune	1	1
Oral Cancer	1	1
Osteoarthritis	1	1
Overweight	1	1
Periodontal Diseases	1	1
Promyelocytic leukemia	1	1
Respiratory Syncytial Virus Infections	1	1
Retinoblastoma	1	1
Salmonella Infections	1	1
Skin Cancer: Squamous Cell	1	1
Squamous cell carcinoma	1	1
Streptococcus pyogenes	1	1
Thrombocytopenia	1	1
Thyroid Cancer	1	1
Uveitis	1	1

Name	AC	CK
Anti-Inflammatory Agents	71	134
Antioxidants	42	69
Hypolipidemic	14	67
Tumor Necrosis Factor (TNF) Alpha Inhibitor	27	62
Antiproliferative	48	59
Interleukin-6 Downregulation	25	56
Neuroprotective Agents	30	52
Apoptotic	40	49
Cardioprotective	19	49
Hypoglycemic Agents	14	42
Hepatoprotective	18	36
Anticholesteremic Agents	4	34
Anti-Apoptotic	20	32
Interleukin-1 beta downregulation	18	30
MicroRNA modulator	14	24
NF-kappaB Inhibitor	16	23
Chemopreventive	15	21
Anti-metastatic	17	20
Cell cycle arrest	18	20
Anti-Bacterial Agents	6	16
Renoprotective	9	16
Chemotherapeutic	12	14
Cyclooxygenase 2 Inhibitors	9	14
Gastrointestinal Agents	7	14
Antineoplastic Agents	5	13
Nrf2 activation	8	13
Matrix metalloproteinase-2 (MMP-2) inhibitor	9	11
Anti-Fibrotic	5	10
Anticarcinogenic Agents	6	10
Matrix metalloproteinase-9 (MMP-9) inhibitor	7	10
Radioprotective	1	10
Antiviral Agents	7	9
Chemosensitizer	9	9
Osteoprotective	5	9
Gastroprotective	4	8
Malondialdehyde Down-regulation	4	8
Antihypertensive Agents	4	7
Chemoprotective Agents	4	7
Tumor Suppressor Protein p53 Upregulation	6	7
Angiogenesis Inducing Agents	3	6
Antidepressive Agents	3	6
Autophagy Up-regulation	3	6
Enzyme Inhibitors	2	6
Immunomodulatory	4	6
Immunomodulatory: Th17 downregulation	3	6
Insulin Sensitizers	2	6
Anti-Adipogenic	4	5
Antimicrobial	4	5
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	4	5
Pancreato Protective Agents	3	5
Wnt/β-catenin signaling pathway modulation	4	5
Analgesics	2	4
Angiogenesis Inhibitors	3	4
Anti-Anxiety Agents	2	4
Anticonvulsants	2	4
Glucagon Like peptide 1 (GLP-1) Up-regulation	2	4
Interleukin-10 downregulation	2	4
Interleukin-10 upregulation	2	4
Interleukin-17 downregulation	2	4
Prostaglandin PGE2 downregulation	2	4
Anti-Glycation Agents	2	3
Bcl-2 protein down-regulation	3	3
Caspase-3 Activation	2	3
Heme oxygenase-1 up-regulation	2	3
Matrix metalloproteinase-3 (MMP-3) inhibitor	2	3
STAT3 Inhibitor	3	3
Vascular Endothelial Growth Factor Inhibitors	3	3
Anti-Tumor	1	2
Anti-atherogenic	1	2
Antidiarrheals	1	2
Antifungal Agents	2	2
Bax/Bcl2 Ratio: Decrease	1	2
Brain-derived neurotrophic factor modulator	1	2
Caspase-9 Activation	1	2
Cholinesterase Inhibitors	1	2
Enzyme Inhibitors: Pancreatic Amylase	1	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Fibroblast growth factor 21 upregulation	1	2
Interferon Gamma Reducer	1	2
Interleukin-4 downregulation	1	2
Interleukin-8 downregulation	2	2
Iron Chelating Agents	1	2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	2	2
Neuritogenic	1	2
Nitric Oxide Inhibitor	1	2
P21 Activation	2	2
Radiosensitizer	2	2
SIRT1 Activator	1	2
Wnt/β-catenin pathway down-regulation	1	2
interleukin-13 down-regulation	1	2
AMP-activated protein kinase modulation	1	1
Alpha-amylase inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Anti-Allergic Agents	1	1
Anti-Androgen	1	1
Anti-Proliferative	1	1
Autophagy Inhibitors	1	1
Cyclin D1 Down-Regulation	1	1
Cyclin-dependent kinase inhibitor: P16INK4	1	1
Cytoprotective	1	1
Cytotoxic	1	1
Expectorants	1	1
Gluconeogenesis Inhibitor	1	1
HIV Protease Inhibitors	1	1
Interleukin-18 down-regulation	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
Multidrug Resistance Gene Modulators	1	1
Osteogenic	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
Prophylactic Agents	1	1
RANK Downregulation	1	1
Regenerative	1	1
Scolicidal	1	1
Survivin Down-Regulation	1	1
Telomerase Inhibitor	1	1

Berberine exhibits antioxidative effects and reduces apoptosis of the vaginal epithelium in bacterial vaginosis.Aug 31, 2019

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Pubmed Data : Exp Ther Med. 2019 Sep ;18(3):2122-2130. Epub 2019 Jul 12. PMID: 31410167

Article Published Date : Aug 31, 2019

Study Type : Human Study

Additional Links

Substances : Berberine

Diseases : Bacterial Vaginosis

Pharmacological Actions : Anti-Apoptotic, Antioxidants

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Berberine improves diabetic kidney disease by reducing UACR and serum Cys C in T2DM patients.Dec 10, 2018

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 2018 Dec 11 ;98(46):3756-3761. PMID: 30541217

Article Published Date : Dec 10, 2018

Study Type : Human Study

Additional Links

Substances : Berberine

Diseases : Diabetic Complications, Kidney Diseases

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Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy.Feb 01, 2007

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Pubmed Data : J Forensic Leg Med. 2007 Feb;14(2):87-91. PMID: 19757213

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Pubmed Data : Evid Based Complement Alternat Med. 2009 Oct 6; PMID: 19800084

Article Published Date : Oct 06, 2009

Study Type : Human Study

Additional Links

Substances : Berberine

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Drug: Metformin, Drug: Rosiglitazone, Insulin Receptor Upregulation, Natural Substances Versus Drugs

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Berberine possesses potential lipid-regulating, antiarthritis, and synovial hyperplasia inhibition activities against rheumatoid arthritis.Dec 31, 2018

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The role of serum inflammatory cytokines and berberine in the insulin signaling pathway among women with polycystic ovary syndrome.Dec 31, 2019

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Pubmed Data : PLoS One. 2020 ;15(8):e0235404. Epub 2020 Aug 12. PMID: 32785222

Article Published Date : Dec 31, 2019

Study Type : Human Study

Additional Links

Substances : Berberine

Diseases : Insulin Resistance, Polycystic Ovary Syndrome

Pharmacological Actions : Anti-Inflammatory Agents, Insulin Sensitizers

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Berberine can significantly inhibit the activity of N-acetyltransferase in human lung cancer cell line A549.May 31, 2014

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Pubmed Data : PLoS One. 2015 ;10(5):e0123478. Epub 2015 May 8. PMID: 25954974

Article Published Date : Dec 31, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Prostaglandin PGE2 downregulation

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Berberine attenuates the abnormal ectopic lipid deposition in skeletal muscle.Jul 30, 2020

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Pubmed Data : Free Radic Biol Med. 2020 Jul 31. Epub 2020 Jul 31. PMID: 32745766

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Pubmed Data : Front Immunol. 2020 ;11:588079. Epub 2020 Sep 24. PMID: 33072135

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Colorectal Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

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A relatively low dose berberine exhibited strong neuroprotective activity against 6-OHDA-induced neurotoxicity in PC12 cells.Nov 03, 2016

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Pubmed Data : Chem Biol Interact. 2018 Aug 21 ;294:91-100. Epub 2018 Aug 21. PMID: 30138605

Article Published Date : Aug 20, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective

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Autologous erythrocytes delivery of berberine hydrochloride with long-acting effect for hypolipidemia treatment.Nov 30, 2020

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Pubmed Data : Drug Deliv. 2020 Dec ;27(1):283-291. PMID: 32013620

Article Published Date : Nov 30, 2020

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Hyperlipidemia

Pharmacological Actions : Hypolipidemic

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Berbamine induces programmed cell death in human liver cancer cells and inhibits tumor growth in mice. Jan 01, 2009

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Pubmed Data : J Asian Nat Prod Res. 2009;11(3):219-28. PMID: 19408145

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation

[+]

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Pubmed Data : Exp Ther Med. 2017 Jun ;13(6):3374-3382. Epub 2017 Apr 28. PMID: 28587416

Article Published Date : May 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

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Berberine alleviates disease symptoms in mouse models mimicking the symptoms of IBS-D. Dec 31, 2014

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Pubmed Data : Arch Physiol Biochem. 2020 Feb 19:1-12. Epub 2020 Feb 19. PMID: 32072839

Article Published Date : Feb 18, 2020

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Endothelial Dysfunction, Inflammation

Pharmacological Actions : Vasoprotective

Problem Substances : Monosodium Glutamate (MSG)

[+]

Berberine alleviates NASH and its predisposing factors.Feb 29, 2016

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Pubmed Data : Arch Iran Med. 2016 Mar ;19(3):197-203. PMID: 26923892

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Berberine ameliorates NSAIDs-induced intestinal injury by the repair of enteric nervous system.Sep 12, 2019

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Pubmed Data : Fundam Clin Pharmacol. 2019 Sep 13. Epub 2019 Sep 13. PMID: 31520444

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Pubmed Data : Front Cell Neurosci. 2020 ;14:87. Epub 2020 Apr 9. PMID: 32327976

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Pubmed Data : J Cell Physiol. 2019 Feb 20. Epub 2019 Feb 20. PMID: 30786011

Article Published Date : Feb 19, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Hypertension, Hypoxia

Pharmacological Actions : Antihypertensive Agents

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Berberine attenuates intestinal tumorigenesis by inhibiting the migration and invasion of colorectal tumor cells.Dec 31, 2015

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Pubmed Data : Free Radic Biol Med. 2019 Jun 18 ;141:192-204. Epub 2019 Jun 18. PMID: 31226399

Article Published Date : Jun 17, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

[+]

Berberine attenuates olanzapine induced-metabolic syndrome.Jul 31, 2019

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Pubmed Data : J Pak Med Assoc. 2019 Aug ;69(Suppl 3)(8):S88-S92. PMID: 31603885

Article Published Date : Jul 31, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Metabolic Diseases

Pharmacological Actions : Hypolipidemic

Problem Substances : Olanzapine

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Berberine can improve insulin resistance of skeletal muscle in rats. Oct 31, 2015

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Pubmed Data : Sichuan Da Xue Xue Bao Yi Xue Ban. 2015 Nov ;46(6):827-31. PMID: 26867315

Article Published Date : Oct 31, 2015

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Insulin Resistance

Pharmacological Actions : Anti-Inflammatory Agents

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Berberine can improve myocardial injury and cardiac function in sepsis.Sep 21, 2020

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 2020 Sep 22 ;100(35):2779-2784. PMID: 32972060

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Pubmed Data : Avicenna J Phytomed. 2016 Mar-Apr;6(2):198-204. PMID: 27222833

Article Published Date : Feb 29, 2016

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Morphine Tolerance/Dependence

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Berberine can reverse chronic inflammatory pain induced by complete freund's adjuvant and alleviated the comorbid depression.Apr 09, 2018

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 2018 Apr 10 ;98(14):1103-1108. PMID: 29690724

Article Published Date : Apr 09, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Depression, Hyperalgesia, Inflammation

Pharmacological Actions : Analgesics, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Berberine can suppress the proliferation of liver cancer cells by reducing SLC1A5 expression.Dec 31, 2018

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Pubmed Data : Cancer Chemother Pharmacol. 2020 Jul ;86(1):151-161. Epub 2020 Jun 30. PMID: 32607786

Article Published Date : Jun 30, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Antiproliferative

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Berberine clears Aβ deposit and consequently ameliorates spatial learning memory impairment.Dec 31, 2018

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Pubmed Data : Diabetes Metab Syndr Obes. 2020 ;13:4561-4569. Epub 2020 Nov 23. PMID: 33262628

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Insulin Resistance

Pharmacological Actions : Anti-Inflammatory Agents

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Berberine enhances L1 expression and axonal remyelination in rats after brachial plexus root avulsion.Aug 06, 2020

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Pubmed Data : Brain Behav. 2020 Aug 7:e01792. Epub 2020 Aug 7. PMID: 32770668

Article Published Date : Aug 06, 2020

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Nerve Injuries

Pharmacological Actions : Regenerative

Additional Keywords : Nerve Regeneration

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Berberine exerted a protective effect on gut-vascular barrier function in sepsis.Sep 10, 2018

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Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:1319-1326. Epub 2018 May 7. PMID: 29864914

Berberine impairs coxsackievirus B3-induced myocarditis through the inhibition of virus replication and host pro-inflammatory response.Dec 17, 2020

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Pubmed Data : J Med Virol. 2020 Dec 18. Epub 2020 Dec 18. PMID: 33336842

Article Published Date : Dec 17, 2020

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Coxsackievirus Infections, Myocarditis: Viral

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective

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Berberine improved metabolic function in a mouse model fed a high-fat diet.Jan 03, 2019

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Pubmed Data : Med Sci Monit. 2019 Jan 4 ;25:87-97. Epub 2019 Jan 4. PMID: 30606998

Article Published Date : Jan 03, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : High Fat Diet

Pharmacological Actions : Anti-Inflammatory Agents

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Berberine improves benign prostatic hyperplasia.Dec 31, 2017

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Pubmed Data : Front Pharmacol. 2018 ;9:773. Epub 2018 Jul 16. PMID: 30061836

Article Published Date : Dec 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Prostatic Hyperplasia: Benign

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Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites.Dec 03, 2020

Pubmed Data : Mol Cancer Ther. 2015 Feb ;14(2):355-63. Epub 2014 Dec 12. PMID: 25504754

Article Published Date : Jan 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Glioblastoma

Pharmacological Actions : Anti-Tumor, Apoptotic, Cell cycle arrest, Epidermal growth factor receptor (EGFR) inhibitor

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Berberine inhibited angiogenesis in glioblastoma xenografts.Nov 30, 2018

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Pubmed Data : Sci Rep. 2016 ;6:20848. Epub 2016 Feb 9. PMID: 26857750

Article Published Date : Dec 31, 2015

Study Type : Animal Study, In Vitro Study

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Substances : Berberine

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

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Berberine may be a potential therapeutic agent for the treatment of patients with neonatal necrotizing enterocolitis.Mar 31, 2018

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Pubmed Data : Mol Med Rep. 2017 May ;15(5):2765-2787. Epub 2017 Mar 14. PMID: 28447763

Article Published Date : Apr 30, 2017

Study Type : Animal Study

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Substances : Berberine

Diseases : Insulin Resistance, Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Gastrointestinal Agents

Additional Keywords : Microbiota

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Berberine prevents stress-induced gut inflammation and visceral hypersensitivity and reduces intestinal motility in rats.Aug 06, 2019

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Pubmed Data : World J Gastroenterol. 2019 Aug 7 ;25(29):3956-3971. PMID: 31413530

Article Published Date : Aug 06, 2019

Study Type : Animal Study

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Substances : Berberine

Diseases : Gastrointestinal Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor

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Berberine prevents the progression of type 1 diabetes in mice through decreased Th17 and Th1 cytokine secretion. Oct 09, 2009

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Pubmed Data : Zhong Yao Cai. 2011 Mar ;34(3):412-5. PMID: 21823461

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Pubmed Data : Life Sci. 2020 Dec 16 ;266:118903. Epub 2020 Dec 16. PMID: 33340526

Article Published Date : Dec 15, 2020

Study Type : Animal Study

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Substances : Berberine

Diseases : Gastritis, Helicobacter Pylori Infection

Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents, Interleukin-4 upregulation

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Pharmacological Actions : Anti-metastatic, Antiproliferative , Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation

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Berberine suppresses influenza virus-triggered NLRP3 inflammasome activation in macrophages.Apr 08, 2020

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Pubmed Data : J Leukoc Biol. 2020 Apr 9. Epub 2020 Apr 9. PMID: 32272506

Article Published Date : Apr 08, 2020

Study Type : Animal Study, In Vitro Study

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Substances : Berberine

Diseases : Inflammation, Influenza

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

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Berberine treatment improved short-term memory in hyperlipidemia.Oct 31, 2019

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Pubmed Data : Int Neurourol J. 2019 Nov ;23(Suppl 2):S102-110. Epub 2019 Nov 30. PMID: 31795609

Article Published Date : Oct 31, 2019

Study Type : Animal Study

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Substances : Berberine

Diseases : Brain Inflammation , Hyperlipidemia

Pharmacological Actions : Anti-Inflammatory Agents, Anticholesteremic Agents, Hypolipidemic

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Berberine treatment reduced hepatic injury caused by concanavalin A.Dec 27, 2017

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Pubmed Data : Med Sci Monit. 2017 Dec 28 ;23:6150-6161. Epub 2017 Dec 28. PMID: 29283990

Article Published Date : Dec 27, 2017

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Pubmed Data : Rhinology. 2015 Aug 15. Epub 2015 Aug 15. PMID: 26275466

Article Published Date : Aug 14, 2015

Study Type : Animal Study

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Substances : Berberine

Diseases : Allergic Rhinitis, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation, MicroRNA modulator

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Berberine-loaded liposomes for the treatment of Leishmania infantum.Sep 08, 2020

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Pubmed Data : Pharmaceutics. 2020 Sep 9 ;12(9). Epub 2020 Sep 9. PMID: 32916948

Article Published Date : Sep 08, 2020

Study Type : Animal Study

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Substances : Berberine

Diseases : Leishmaniasis

Pharmacological Actions : Leishmanicidal

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Berberine-loaded M2 macrophage-derived exosomes for spinal cord injury therapy.Mar 11, 2021

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Pubmed Data : Acta Biomater. 2021 Mar 12. Epub 2021 Mar 12. PMID: 33722788

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Pubmed Data : Int J Crit Illn Inj Sci. 2019 Apr-Jun;9(2):69-74. PMID: 31334048

Article Published Date : Mar 31, 2019

Study Type : Animal Study

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Substances : Berberine

Diseases : Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Diclofenac

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Combination of berberine with resveratrol improves the lipid-lowering efficacy.Dec 05, 2018

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Pubmed Data : Int J Mol Sci. 2018 Dec 6 ;19(12). Epub 2018 Dec 6. PMID: 30563192

Article Published Date : Dec 05, 2018

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Pubmed Data : Environ Sci Pollut Res Int. 2019 Dec 16. Epub 2019 Dec 16. PMID: 31845254

Article Published Date : Dec 15, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Chemically-Induced Liver Damage, Pesticide Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Paraquat

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High concentrations of berberine markedly protects rats from various symptoms of chronic stress and depression.Mar 21, 2017

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Pubmed Data : Mol Med Rep. 2017 Mar 22. Epub 2017 Mar 22. PMID: 28339024

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Pharmacological Actions : Anti-Apoptotic, Anticonvulsants, Antioxidants

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The present study determined the anti-hyperlipidemia effect of berberine compounds on diet-induced hyperlipidemic rats.Dec 31, 2015

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Pubmed Data : J Transl Med. 2016 ;14(1):237. Epub 2016 Aug 5. PMID: 27495782

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : High Fat Diet, Hyperlipidemia

Pharmacological Actions : Gastrointestinal Agents

Additional Keywords : Microbiota

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The protective effect of berberine against lipopolysaccharide-induced abortion.Jul 12, 2018

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Pubmed Data : Immunopharmacol Immunotoxicol. 2018 Jul 13:1-5. Epub 2018 Jul 13. PMID: 30003821

Article Published Date : Jul 12, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Lipopolysaccharide-Induced Toxicity, Miscarriage

Pharmacological Actions : Anti-Inflammatory Agents

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The protective effects of berberine and hesperidin on inflammatory factor-stimulating cardiac fibroblasts.May 31, 2019

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Pubmed Data : Eur Rev Med Pharmacol Sci. 2019 Jun ;23(12):5468-5476. PMID: 31298400

Article Published Date : May 31, 20

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View the Evidence: 626 Abstracts with Berberine Research

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A nutraceutical combination has shown to be an effective product for the improvement of the lipid profile.Apr 26, 2016

Berberine and dyslipidemia: different applications and biopharmaceutical formulations without statin-like molecules.Aug 22, 2019

Berberine exerted anti-tumor effects in a variety of tumors in vivo.Jun 16, 2019

Berberine showed a promising prospect in treating polycystic ovary syndrome patients with insulin resistance.Dec 31, 2017

Berberine supplementation may ameliorate the state of chronic inflammation.Sep 30, 2019

Systematic review and meta-analysis on efficacy and safety of berberine for dyslipidemiaJan 31, 2020

The addition of berberine in standard triple therapy could improve Helicobacter pylori eradication rate and clinical symptom remission rate.Dec 31, 2018

The results of the current study support the use of berberine supplementation for the improvement of obesity indices.Apr 30, 2020

These results found a significant reduction in waist-hip ratio following berberine consumption in adults.Feb 29, 2020

This meta-analysis found a significant reduction of body weight, BMI, WC and CRP levels associated with berberine intake.Jul 31, 2020

A combination of berberine, red yeast rice and policosanol lowers lipid levels and improves endothelial function and insulin sensitivity in hypercholesterolemic patients. Aug 19, 2009

A nutraceutical formula containing berberine, chlorogenic acid, and tocotrienols was found to improve a large number of metabolic and liver parameters in overweight subjects.Mar 28, 2015

Berberine Capsule was effective in improving blood lipid level in mild hyperlipidemia patients.May 31, 2016

Berberine containing quadruple therapy could be used for Helicobacter pylori eradication.Jul 31, 2017

Berberine exhibits antioxidative effects and reduces apoptosis of the vaginal epithelium in bacterial vaginosis.Aug 31, 2019

Berberine improves diabetic kidney disease by reducing UACR and serum Cys C in T2DM patients.Dec 10, 2018

Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy.Feb 01, 2007

Berberine is a potent oral hypoglycemic agent with benefical effects on lipid metabolism, comparable in efficacy to metformin. May 01, 2008

Berberine is efficacious for the treatment of atrial fibrillation.Dec 31, 2016

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.Oct 06, 2009

Berberine possesses potential lipid-regulating, antiarthritis, and synovial hyperplasia inhibition activities against rheumatoid arthritis.Dec 31, 2018

Berberine promoted myocardial protection of postoperative patients through regulating myocardial autophagy.Aug 31, 2018

Berberine was safe and effective in reducing the risk of recurrence of colorectal adenoma.Jan 07, 2020

Dry extracts of artichoke and berberine have beneficial effects in hypercholesterolemic patients.Feb 14, 2019

Hop rho iso-alpha acids, berberine, vitamin D(3) and vitamin K (1) favorably impact biomarkers of bone turnover in postmenopausal women. Dec 19, 2009

Role of a berberine-based nutritional supplement in reducing diarrhea in subjects with functional gastrointestinal disorders.Feb 29, 2020

The combined application of berberine in patients with metabolic syndrome can effectively regulate blood glucose and blood lipid of patients.Mar 31, 2019

The role of serum inflammatory cytokines and berberine in the insulin signaling pathway among women with polycystic ovary syndrome.Dec 31, 2019

Berberine can significantly inhibit the activity of N-acetyltransferase in human lung cancer cell line A549.May 31, 2014

Berberine induced apoptosis and DNA damage in human osteosarcoma lines that were treated.Sep 30, 2014

Berberine may serve as a potential therapeutic option for patients with psoriasis.Mar 19, 2019

These results suggest that berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokine profile in human preadipocytes and metabolic syndrome patients.Mar 07, 2012

Remission of new-onset type 2 diabetes mellitus in an adolescent using an integrative medicine approach.Oct 21, 2020

Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.Dec 31, 2014

Berberine attenuates the abnormal ectopic lipid deposition in skeletal muscle.Jul 30, 2020

Berberine improves neointima formation in a rat model.May 01, 2006

A berberine derivative attenuates cardiac failure. Feb 01, 2010

A holistic view of berberine inhibiting intestinal carcinogenesis.Dec 31, 2019

A relatively low dose berberine exhibited strong neuroprotective activity against 6-OHDA-induced neurotoxicity in PC12 cells.Nov 03, 2016

Administration of Berberis vulgaris could ameliorate neurotoxicity induced by beta amyloid. Jul 04, 2015

Ameliorating effects of berberine on MK-801-induced cognitive and motor impairments in a neonatal rat model of schizophrenia.May 15, 2019

Ameliorating ribosylation-induced amyloid-β pathology by berberine.Dec 22, 2020

Ameliorative effect of berberine on neonatally induced type 2 diabetic neuropathy.Jun 30, 2019

An inhibitory effect of Berberine from herbal Coptis chinensis Franch on rat detrusor contraction in benign prostatic hyperplasia associated with lower urinary tract symptoms.Dec 06, 2020

Anti-inflammation associated protective mechanism of berberine and its derivatives on attenuating pentylenetetrazole-induced seizures.Jan 05, 2020

Anti-influenza activity of berberine improves prognosis by reducing viral replication in mice.Oct 10, 2018

Anticolitic effect of berberine in rat experimental model.Dec 31, 2019

Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis.Aug 20, 2018

Autologous erythrocytes delivery of berberine hydrochloride with long-acting effect for hypolipidemia treatment.Nov 30, 2020

Berbamine induces programmed cell death in human liver cancer cells and inhibits tumor growth in mice. Jan 01, 2009

Berberine (a major constituent of goldenseal) has significant cholesterol-lowering action Dec 01, 2004

Berberine activates apoptosis to suppress triple-negative breast cancer cells.Aug 17, 2017

Berberine alleviated doxorubicin induced cardiotoxicity via inhibition of the metabolism of doxorubicin and reduced accumulation of doxorubicinol selectively in hearts.May 12, 2015

Berberine alleviates adipose tissue fibrosis.May 27, 2018

Berberine alleviates amyloid-beta pathogenesis.Mar 14, 2019

Berberine alleviates amyloid-beta pathology in the brain of APP/PS1 transgenic mice.Jun 30, 2018

Berberine alleviates dextran sodium sulfate-induced colitis.May 31, 2017

Berberine alleviates disease symptoms in mouse models mimicking the symptoms of IBS-D. Dec 31, 2014

Berberine alleviates endothelial glycocalyx degradation and promotes glycocalyx restoration in LPS-induced ARDS.Oct 07, 2018

Berberine alleviates hepatic lipid accumulation.Mar 01, 2018

Berberine alleviates hyperglycemia by targeting hepatic glucokinase.May 28, 2019

Berberine alleviates monosodium glutamate induced postnatal metabolic disorders associated vascular endothelial dysfunction.Feb 18, 2020

Berberine alleviates NASH and its predisposing factors.Feb 29, 2016

Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3.Mar 07, 2019

Berberine alleviates oxidative stress in islets of diabetic mice.Apr 23, 2017

Berberine alleviates oxidative stress in rats with osteoporosis.Oct 21, 2017

Berberine alleviates paclitaxel-induced neuropathy.May 31, 2019

Berberine alleviates symptoms of anxiety by enhancing dopamine expression in rats with post-traumatic stress disorder.Feb 28, 2018

Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression.Nov 25, 2019

Berberine ameliorates collagen-induced arthritis in rats by facilitating the generation of butyrate and adjusting the intestinal hypoxia and nitrate supply.Aug 18, 2019

Berberine ameliorates colonic damage accompanied with the modulation of dysfunctional bacteria and functions in ulcerative colitis rats.Jan 31, 2020

Berberine ameliorates diabetic nephropathy.Mar 30, 2018

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View the Evidence:
626 Abstracts with Berberine Research