Berberine

Name	AC	CK
Insulin Resistance	23	92
Obesity	24	89
Diabetes Mellitus: Type 2	33	77
Inflammation	24	71
Hyperlipidemia	14	58
Dyslipidemias	3	41
C-Reactive Protein	2	40
Polycystic Ovary Syndrome	9	40
Breast Cancer	19	39
Cancers: All	18	38
Alzheimer's Disease	25	37
Helicobacter Pylori Infection	6	37
Lung Cancer	10	33
Nonalcoholic fatty liver disease (NAFLD)	17	31
Liver Cancer	20	25
Colorectal Cancer	10	24
Diabetic Complications	8	24
High Cholesterol	2	22
Hypercholesterolemia	3	22
Triglycerides: Elevated	2	22
Lipopolysaccharide-Induced Toxicity	14	21
Myocardial Ischemia	7	20
Colon Cancer	13	18
Osteoporosis	6	18
Rheumatoid Arthritis	8	18
Metabolic Diseases	6	17
Colitis	8	15
Diabetic Nephropathy	7	14
Atherosclerosis	8	13
Breast Cancer: Triple Negative	11	13
Cerebral Ischemia	7	13
High Fat Diet	7	13
Hyperglycemia	8	13
Ulcerative Colitis	8	13
Brain Inflammation	6	12
Depression	6	12
Endothelial Dysfunction	2	12
Fatty Liver	2	12
Kidney Diseases	2	12
Oxidative Stress	8	12
Diarrhea	2	11
Gastric Cancer	9	11
Glioblastoma	8	11
Atrial Fibrillation	1	10
Bacterial Vaginosis	1	10
Cognitive Decline/Dysfunction	5	10
Gastrointestinal Diseases	1	10
Osteosarcoma	5	10
Pancreatitis	6	10
Radiation Induced Illness	1	10
Sepsis	5	9
Cancers: Drug Resistant	7	8
Chemically-Induced Liver Damage	4	8
Heart Failure	5	8
Hypertension	5	8
Ischemia	5	8
Metabolic Syndrome X	4	8
Arthritis	4	7
Diabetes Mellitus: Type 1	4	7
Diabetes: Cognitive Dysfunction	4	7
Diabetic Neuropathy	4	7
Neurodegenerative Diseases	6	7
Carcinoma: Non-Small-Cell Lung	5	6
Cardiomyopathy	3	6
Cardiovascular Diseases	5	6
Epilepsy	3	6
Hypoxia	4	6
Melanoma	6	6
Ovarian Cancer	6	6
Autoimmune Diseases	3	5
Candida Albicans	5	5
Cervical Cancer	5	5
Chemotherapy-Induced Toxicity: Doxorubicin	3	5
Glioma	4	5
Influenza	3	5
Peripheral Neuropathies	3	5
Psoriasis	1	5
Acetaminophen (Tylenol) Toxicity	2	4
Advanced Glycation End products (AGE)	3	4
Alcohol Toxicity	2	4
Allergic Rhinitis	2	4
Asthma	3	4
Chemotherapy-Induced Toxicity: Paclitaxel	2	4
Chikungunya Virus	3	4
Enterocolitis: Necrotiziing	2	4
Fibrosis	2	4
Fructose-Induced Toxicity	2	4
Gastritis	2	4
Kidney Damage: Drug-Induced	2	4
Myocardial Infarction	2	4
Nasopharyngeal Cancer	3	4
Periodontitis	2	4
Prostatic Hyperplasia: Benign	2	4
Pseudomonas aeruginosa	3	4
Traumatic Brain Injury	2	4
Acute T cell Leukemias	3	3
Brain Ischemia	2	3
Brain: Oxidative Stress	2	3
Cancer Metastasis	3	3
Coxsackievirus Infections	2	3
Dementia	2	3
Diabetes: Oxidative Stress	2	3
Diabetic Retinopathy	3	3
Endometrial Cancer	2	3
Escherichia coli Infections	2	3
Hepatic Steatosis	2	3
Hydrogen Peroxide Induced Toxicity	3	3
Hypoglycemia	2	3
Leishmaniasis	2	3
Liver Fibrosis	2	3
Spinal Cord Injuries	2	3
Uveitis	2	3
Acute Respiratory Distress Syndrome	1	2
Adenomyosis	2	2
Aging	1	2
Aging: Brain	1	2
Alcoholic Liver Disease	1	2
Aluminum Toxicity	1	2
Aneurysm: Cerebral	1	2
Anxiety	1	2
Arsenic Poisoning	1	2
Arterial Hardening: Elasticity	1	2
Atopic Dermatitis	1	2
Autism	1	2
Bladder Dysfunction	1	2
Blood-Brain-Barrier Disorders	1	2
Bone Diseases	1	2
Brain Injury: Traumatic	1	2
Breast Cancer: Chemically-Induced	1	2
Bubonic Plague	1	2
Candida Infection	2	2
Cardiac Hypertrophy	1	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Chronic Myeloid Leukemia	1	2
Cocaine Withdrawal	1	2
Colon Cancer: Prevention	1	2
Colorectal Cancer: Prevention	1	2
Colorectal Tumors	1	2
Congestive Heart Failure	1	2
Convulsions	1	2
Coronavirus Infection	2	2
Cytomegalovirus Infections	2	2
Degenerative Disk Disease	2	2
Demyelinating Diseases	1	2
Diabesity	1	2
Diabetic Neuropathies	1	2
Diarrhea: Drug-Associated	1	2
Drug-Induced Toxicity: Gastrointestinal	1	2
Drug-Induced Toxicity: L-Thyroxine	1	2
Drug-Induced Toxicity: Methotrexate	1	2
Endothelial Damage	1	2
Erectile Dysfunction	1	2
Fetal Origin of Adult Disease	1	2
Gastric Polyposis	1	2
Gastrointestinal Inflammation	1	2
Graft vs Host Disease	1	2
HIV Infections	2	2
Heavy Metal Toxicity	1	2
Hepatitis: Autoimmune	1	2
High Homocysteine	1	2
Huntington Disease	1	2
Hyperalgesia	1	2
Hypersensitivity: Type IV	1	2
Hypertension: Pulmonary	1	2
Hypertension: Renal	1	2
Hyperuricemia	1	2
Immune Dysregulation: TH1 dominance	1	2
Immune Dysregulation: TH17 over-expression	1	2
Infertility: Male	1	2
Insomnia	1	2
Intestinal Permeability	1	2
Intestinal Polyps	1	2
Intima Media Thickening	1	2
Iron Overload	1	2
Irritable Bowel Syndrome	1	2
Kidney Fibrosis	1	2
Lead Poisoning	1	2
Learning disorders	1	2
Leukemia	2	2
Lipid Peroxidation	1	2
Liver Steatosis	1	2
Liver Stress: Fructose-Induced	1	2
Lung Cancer: Prevention	1	2
Malignant Melanoma	2	2
Mastitis	1	2
Memory Disorders: Drug-Induced	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Miscarriage	1	2
Morphine Tolerance/Dependence	1	2
Mucositis	1	2
Multiple Myeloma	2	2
Multiple Sclerosis	1	2
Muscle Damage: Exercise-Induced	1	2
Myocardial Fibrosis	1	2
Myocarditis: Viral	1	2
Nerve Injuries	1	2
Neuroblastoma	2	2
Neuropathic Pain	1	2
Non-Small-Cell Lung Carcinoma	2	2
Osteoarthritis	2	2
Pancreatic Cancer	2	2
Parkinson's Disease	1	2
Peripheral Nerve Diseases	1	2
Pesticide Toxicity	1	2
Post-Traumatic Stress Disorders (PTSD)	1	2
Postmenopausal Disorders	1	2
Postoperative Recovery	1	2
Prehypertension	1	2
Promyelocytic leukemia	2	2
Prostate Cancer	2	2
Psychiatric Disorders	1	2
Retinal Diseases	1	2
Schizophrenia	1	2
Seizures	1	2
Seizures: Drug-Induced	1	2
Smoking Cessation: Nicotine Addiction	1	2
Staphylococcal Infections	1	2
Staphylococcus aureus infection	2	2
Staphylococcus aureus: Methicillin-resistant (MRSA)	2	2
Stroke: Ischemic	1	2
Tongue Cancer	1	2
Uremia	1	2
Uveoretinitis	1	2
Varicocele	1	2
Acute Myeloid Leukemia	1	1
Acute lymphoblastic leukemia (ALL)	1	1
Allergic Airway Diseases	1	1
Allergies	1	1
Alphavirus Infections	1	1
Arthritis: Rheumatoid	1	1
Bacillus Cereus infection	1	1
Bacterial Infections and Mycoses	1	1
Bladder Cancer	1	1
Breast Cancer Stem Cells	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Cancer: Virus-Induced	1	1
Cancers: Multi-Drug Resistant	1	1
Cardiac Arrhythmias	1	1
Chemotherapy-Induced Kidney Damage	1	1
Chemotherapy-Induced Toxicity: Cisplatin	1	1
Cholangiocarcinoma	1	1
Cholesterol: Oxidation	1	1
Chondrosarcoma	1	1
Chronic Disease	1	1
Chronic Kidney Disease (CKD)	1	1
Chronic Lymphocytic Leukemia	1	1
Chronic Obstructive Pulmonary Disease	1	1
Clostridium Infections	1	1
Corticosteroid-Induced Toxicity	1	1
Dementia: Senile	1	1
Dental Caries	1	1
Diabetes Mellitus: Type 2: Prevention	1	1
Diabetes: Glycation/A1C	1	1
Diabetes: Kidney Function	1	1
Diarrhea: in Children	1	1
Dysbiosis	1	1
Echinococcosis	1	1
Enterococcus Infections	1	1
Enterovirus 71	1	1
Enterovirus: Type 71	1	1
Esophageal Cancer	1	1
Eye Diseases	1	1
Friend Virus	1	1
Fungal Infection	1	1
Gastrointestinal Cancer	1	1
HIV Drug-Induced Toxicity	1	1
Head and Neck Cancer	1	1
Herpes Simplex Virus Type 1	1	1
Herpes Simplex Virus Type 2	1	1
High Sugar Diet	1	1
Human Papillomavirus (HPV)	1	1
Hydatid Cyst	1	1
Inflammatory Bowel Diseases	1	1
Kawasaki Disease	1	1
Kidney Cancer	1	1
Kidney Damage	1	1
Laryngeal Cancer	1	1
Leaky Gut Syndrome	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Leukemia: Chronic Lymphocytic Leukemia (CLL)	1	1
Leukemia: Virus-Induced	1	1
Liver Damage	1	1
Lower Respiratory Infections	1	1
Lung Injury: Acute	1	1
Lymphangioendothelioma	1	1
Macular Degeneration	1	1
Mesothelioma	1	1
Microcystis aeruginosa	1	1
Myocarditis: Autoimmune	1	1
Oral Cancer	1	1
Overweight	1	1
Periodontal Diseases	1	1
Pulmonary Fibrosis	1	1
Respiratory Syncytial Virus Infections	1	1
Retinoblastoma	1	1
Rhabdomyosarcoma	1	1
Salmonella Infections	1	1
Skin Cancer: Squamous Cell	1	1
Squamous cell carcinoma	1	1
Streptococcus pyogenes	1	1
Subarachnoid hemorrhage	1	1
Thrombocytopenia	1	1
Thyroid Cancer	1	1

Name	AC	CK
Anti-Inflammatory Agents	134	266
Antiproliferative	79	116
Hypolipidemic	28	114
Antioxidants	64	107
Tumor Necrosis Factor (TNF) Alpha Inhibitor	45	99
Interleukin-6 Downregulation	43	93
Neuroprotective Agents	54	87
Apoptotic	62	72
Gastrointestinal Agents	25	71
Cardioprotective	28	64
Anticholesteremic Agents	9	60
Chemopreventive	23	59
Interleukin-1 beta downregulation	33	56
Hepatoprotective	29	54
Anti-Apoptotic	29	53
Hypoglycemic Agents	21	53
Anti-Bacterial Agents	12	42
NF-kappaB Inhibitor	28	41
MicroRNA modulator	27	39
Anti-metastatic	27	30
Renoprotective	16	27
Cell cycle arrest	23	26
Chemotherapeutic	22	24
Insulin Sensitizers	7	21
Chemosensitizer	18	19
Cyclooxygenase 2 Inhibitors	11	18
Autophagy Up-regulation	11	17
Gastroprotective	8	16
Immunomodulatory	12	16
Nrf2 activation	11	16
Antidiarrheals	4	14
Antineoplastic Agents	5	13
Antiviral Agents	11	13
Chemoprotective Agents	8	13
Anti-Fibrotic	7	12
Anticarcinogenic Agents	7	12
Matrix metalloproteinase-2 (MMP-2) inhibitor	10	12
Matrix metalloproteinase-9 (MMP-9) inhibitor	8	11
Antihypertensive Agents	6	10
Osteoprotective	6	10
Radioprotective	1	10
Antidepressive Agents	4	8
Antimicrobial	7	8
Interleukin-10 upregulation	4	8
Malondialdehyde Down-regulation	4	8
Pancreato Protective Agents	5	8
Tumor Suppressor Protein p53 Upregulation	7	8
Wnt/β-catenin signaling pathway modulation	7	8
Angiogenesis Inhibitors	5	7
Angiogenesis Inducing Agents	3	6
Anti-Adipogenic	5	6
Anti-Anxiety Agents	3	6
Anticonvulsants	3	6
Cytoprotective	4	6
Enzyme Inhibitors	2	6
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	5	6
Immunomodulatory: Th17 downregulation	3	6
STAT3 Inhibitor	4	5
Analgesics	2	4
Antifungal Agents	4	4
Bcl-2 protein down-regulation	4	4
Brain-derived neurotrophic factor modulator	2	4
Glucagon Like peptide 1 (GLP-1) Up-regulation	2	4
Heme oxygenase-1 up-regulation	3	4
Interleukin-10 downregulation	2	4
Interleukin-17 downregulation	2	4
Prostaglandin PGE2 downregulation	2	4
Radiosensitizer	3	4
Regenerative	3	4
Transforming growth factor beta (TGF-β) inhibitor	2	4
Vasoprotective	2	4
Anti-Glycation Agents	2	3
Anti-atherogenic	2	3
Caspase-3 Activation	2	3
Interleukin-8 downregulation	3	3
Matrix metalloproteinase-3 (MMP-3) inhibitor	2	3
Vascular Endothelial Growth Factor Inhibitors	3	3
Alpha-glucosidase inhibitor	2	2
Anti-Tumor	1	2
Bax/Bcl2 Ratio: Decrease	1	2
Caspase-9 Activation	1	2
Cholinesterase Inhibitors	1	2
Cytotoxic	2	2
Enzyme Inhibitors: Pancreatic Amylase	1	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Fertility Agents: Male	1	2
Fibroblast growth factor 21 upregulation	1	2
Immunosuppressive Agents	1	2
Interferon Gamma Reducer	1	2
Interleukin-1 alpha downregulation	2	2
Interleukin-4 downregulation	1	2
Interleukin-4 upregulation	1	2
Iron Chelating Agents	1	2
Leishmanicidal	1	2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	2	2
Neuritogenic	1	2
Nitric Oxide Inhibitor	1	2
P21 Activation	2	2
Photosensitizing Agents	2	2
SIRT1 Activator	1	2
Uricosuric Agents	1	2
Wnt/β-catenin pathway down-regulation	1	2
interleukin-13 down-regulation	1	2
AMP-activated protein kinase modulation	1	1
Acetylcholinesterase Inhibitor	1	1
Alpha-amylase inhibitor	1	1
Anti-Allergic Agents	1	1
Anti-Androgen	1	1
Anti-Proliferative	1	1
Antioxidant Effects	1	1
Autophagy Inhibitors	1	1
Cyclin D1 Down-Regulation	1	1
Cyclin-dependent kinase inhibitor: P16INK4	1	1
Expectorants	1	1
Gluconeogenesis Inhibitor	1	1
HIV Protease Inhibitors	1	1
Interleukin-18 down-regulation	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
Multidrug Resistance Gene Modulators	1	1
Osteogenic	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
Prophylactic Agents	1	1
RANK Downregulation	1	1
Scolicidal	1	1
Survivin Down-Regulation	1	1
Telomerase Inhibitor	1	1

[+]

Protective effect of berberine in diabetic nephropathy.Oct 02, 2022

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Pubmed Data : Pharmacol Res. 2022 Oct 3 ;185:106481. Epub 2022 Oct 3. PMID: 36195307

Article Published Date : Oct 02, 2022

Study Type : Meta Analysis, Review

Additional Links

Substances : Berberine

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

The effects of berberine supplementation on cardiovascular risk factors in adults.Dec 31, 2021

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Pubmed Data : Front Nutr. 2022 ;9:1013055. Epub 2022 Oct 14. PMID: 36313096

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Pubmed Data : Front Pharmacol. 2021 ;12:653887. Epub 2021 Apr 26. PMID: 33981233

Article Published Date : Dec 31, 2020

Study Type : Meta Analysis, Review

Additional Links

Substances : Berberine

Diseases : Hyperlipidemia, Obesity

Pharmacological Actions : Hypolipidemic

Additional Keywords : Anti-Obesity Agents

[+]

Berberine exerted anti-tumor effects in a variety of tumors in vivo.Jun 16, 2019

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Pubmed Data : Exp Ther Med. 2019 Sep ;18(3):2122-2130. Epub 2019 Jul 12. PMID: 31410167

Article Published Date : Aug 31, 2019

Study Type : Human Study

Additional Links

Substances : Berberine

Diseases : Bacterial Vaginosis

Pharmacological Actions : Anti-Apoptotic, Antioxidants

[+]

Berberine improves diabetic kidney disease by reducing UACR and serum Cys C in T2DM patients.Dec 10, 2018

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 2018 Dec 11 ;98(46):3756-3761. PMID: 30541217

Article Published Date : Dec 10, 2018

Study Type : Human Study

Additional Links

Substances : Berberine

Diseases : Diabetic Complications, Kidney Diseases

[+]

Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy.Feb 01, 2007

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Pubmed Data : J Forensic Leg Med. 2007 Feb;14(2):87-91. PMID: 19757213

Article Published Date : Feb 01, 2007

Study Type : Human Study

Additional Links

Substances : Berberine

Diseases : Radiation Induced Illness

Pharmacological Actions : Radioprotective

Anti Therapeutic Actions : Radiotherapy

[+]

The role of serum inflammatory cytokines and berberine in the insulin signaling pathway among women with polycystic ovary syndrome.Dec 31, 2019

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Pubmed Data : PLoS One. 2015 ;10(5):e0123478. Epub 2015 May 8. PMID: 25954974

Article Published Date : Dec 31, 2014

Study Type : Animal Study, In Vitro Study

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Substances : Berberine

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Prostaglandin PGE2 downregulation

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[+]

A relatively low dose berberine exhibited strong neuroprotective activity against 6-OHDA-induced neurotoxicity in PC12 cells.Nov 03, 2016

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Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis.Aug 20, 2018

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Pubmed Data : Chem Biol Interact. 2018 Aug 21 ;294:91-100. Epub 2018 Aug 21. PMID: 30138605

Article Published Date : Aug 20, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective

[+]

Autologous erythrocytes delivery of berberine hydrochloride with long-acting effect for hypolipidemia treatment.Nov 30, 2020

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Pubmed Data : Exp Ther Med. 2017 Jun ;13(6):3374-3382. Epub 2017 Apr 28. PMID: 28587416

Article Published Date : May 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Berberine alleviates disease symptoms in mouse models mimicking the symptoms of IBS-D. Dec 31, 2014

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Pubmed Data : Aging Cell. 2019 Nov 26:e13060. Epub 2019 Nov 26. PMID: 31773901

Article Published Date : Nov 25, 2019

Study Type : Animal Study

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Substances : Berberine

Diseases : Aging

Pharmacological Actions : Cytoprotective

[+]

Berberine ameliorates cognitive disorder.Dec 31, 2021

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Pubmed Data : Biol Res. 2018 Mar 31 ;51(1):9. Epub 2018 Mar 31. PMID: 29604956

Article Published Date : Mar 30, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Berberine ameliorates diabetic neuropathy.Nov 08, 2017

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Pubmed Data : Am J Chin Med. 2017 Nov 9:1-15. Epub 2017 Nov 9. PMID: 29121795

[+]

Berberine ameliorates nonalcoholic fatty liver disease by decreasing the liver lipid content.Sep 30, 2021

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Pubmed Data : Exp Ther Med. 2021 Oct ;22(4):1109. Epub 2021 Aug 3. PMID: 34504563

Article Published Date : Sep 30, 2021

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective, Hypolipidemic

[+]

Berberine ameliorates NSAIDs-induced intestinal injury by the repair of enteric nervous system.Sep 12, 2019

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Pubmed Data : Fundam Clin Pharmacol. 2019 Sep 13. Epub 2019 Sep 13. PMID: 31520444

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Pubmed Data : Front Cell Neurosci. 2020 ;14:87. Epub 2020 Apr 9. PMID: 32327976

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Pubmed Data : Inflammation. 2021 Sep 14. Epub 2021 Sep 14. PMID: 34523052

Article Published Date : Sep 13, 2021

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Sepsis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Berberine attenuate staphylococcal enterotoxin B-mediated acute liver injury via regulating HDAC expression.Sep 30, 2018

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Berberine attenuates ischemia-reperfusion injury.Sep 27, 2018

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Pubmed Data : Acta Pharmacol Sin. 2018 Sep 28. Epub 2018 Sep 28. PMID: 30266998

Article Published Date : Sep 27, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Cerebral Ischemia

Pharmacological Actions : Neuroprotective Agents

[+]

Berberine attenuates macrophages infiltration in intracranial aneurysms. Dec 31, 2017

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Pubmed Data : J Cell Physiol. 2018 Aug 5. Epub 2018 Aug 5. PMID: 30078229

Article Published Date : Aug 04, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

[+]

Berberine attenuates sepsis-induced cardiac dysfunction by upregulating the Akt/eNOS pathway in mice.May 31, 2022

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Pubmed Data : Exp Ther Med. 2022 Jun ;23(6):371. Epub 2022 Apr 5. PMID: 35495613

Article Published Date : May 31, 2022

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Sepsis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective

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[+]

Berberine can effectively improve renal function in rats with renal ischemia-reperfusion injury.Aug 31, 2018

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Pubmed Data : Avicenna J Phytomed. 2016 Mar-Apr;6(2):198-204. PMID: 27222833

Article Published Date : Feb 29, 2016

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Morphine Tolerance/Dependence

[+]

Berberine can reverse chronic inflammatory pain induced by complete freund's adjuvant and alleviated the comorbid depression.Apr 09, 2018

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 2018 Apr 10 ;98(14):1103-1108. PMID: 29690724

Article Published Date : Apr 09, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Depression, Hyperalgesia, Inflammation

Pharmacological Actions : Analgesics, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Berberine can suppress the proliferation of liver cancer cells by reducing SLC1A5 expression.Dec 31, 2018

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Pubmed Data : Cancer Chemother Pharmacol. 2020 Jul ;86(1):151-161. Epub 2020 Jun 30. PMID: 32607786

Article Published Date : Jun 30, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Antiproliferative

[+]

Berberine clears Aβ deposit and consequently ameliorates spatial learning memory impairment.Dec 31, 2018

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Pubmed Data : Brain Behav. 2020 Aug 7:e01792. Epub 2020 Aug 7. PMID: 32770668

Article Published Date : Aug 06, 2020

Study Type : Animal Study

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Substances : Berberine

Diseases : Nerve Injuries

Pharmacological Actions : Regenerative

Additional Keywords : Nerve Regeneration

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Berberine exerted a protective effect on gut-vascular barrier function in sepsis.Sep 10, 2018

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Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:1319-1326. Epub 2018 May 7. PMID: 29864914

Berberine impairs coxsackievirus B3-induced myocarditis through the inhibition of virus replication and host pro-inflammatory response.Dec 17, 2020

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Pubmed Data : J Med Virol. 2020 Dec 18. Epub 2020 Dec 18. PMID: 33336842

Article Published Date : Dec 17, 2020

Study Type : Animal Study

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Substances : Berberine

Diseases : Coxsackievirus Infections, Myocarditis: Viral

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective

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Berberine improves insulin-induced diabetic retinopathy in type I and II diabetes.Dec 31, 2020

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Pubmed Data : Int J Biol Sci. 2021 ;17(15):4316-4326. Epub 2021 Oct 20. PMID: 34803500

Article Published Date : Dec 31, 2020

Study Type : Animal Study, In Vitro Study

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Substances : Berberine

Diseases : Diabetic Retinopathy

Pharmacological Actions : Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Vascular Endothelial Growth Factor Inhibitors

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Pubmed Data : Mol Cancer Ther. 2015 Feb ;14(2):355-63. Epub 2014 Dec 12. PMID: 25504754

Article Published Date : Jan 31, 2015

Study Type : Animal Study, In Vitro Study

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Substances : Berberine

Diseases : Glioblastoma

Pharmacological Actions : Anti-Tumor, Apoptotic, Cell cycle arrest, Epidermal growth factor receptor (EGFR) inhibitor

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Berberine inhibited angiogenesis in glioblastoma xenografts.Nov 30, 2018

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Pubmed Data : Mol Immunol. 2016 May 2 ;74:27-38. Epub 2016 May 2. PMID: 27148818

Article Published Date : May 01, 2016

Study Type : Animal Study

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Substances : Berberine

Diseases : Pancreatitis

Pharmacological Actions : Anti-Inflammatory Agents

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Berberine inhibits intestinal carcinogenesis by suppressing intestinal pro-inflammatory genes and oncogenic factors through modulating gut microbiota.May 19, 2022

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Pubmed Data : Sci Rep. 2016 ;6:20848. Epub 2016 Feb 9. PMID: 26857750

Article Published Date : Dec 31, 2015

Study Type : Animal Study, In Vitro Study

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Substances : Berberine

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

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Berberine may be a potential therapeutic agent for the treatment of patients with neonatal necrotizing enterocolitis.Mar 31, 2018

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Pubmed Data : Mol Med Rep. 2017 May ;15(5):2765-2787. Epub 2017 Mar 14. PMID: 28447763

Article Published Date : Apr 30, 2017

Study Type : Animal Study

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Substances : Berberine

Diseases : Insulin Resistance, Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Gastrointestinal Agents

Additional Keywords : Microbiota

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Pubmed Data : Curr Clin Pharmacol. 2020 Jun 28. Epub 2020 Jun 28. PMID: 32598269

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Pubmed Data : J Basic Clin Physiol Pharmacol. 2021 Mar 16. Epub 2021 Mar 16. PMID: 33725758

Article Published Date : Mar 15, 2021

Study Type : Animal Study

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Substances : Berberine

Diseases : Diabetes: Cognitive Dysfunction

Pharmacological Actions : Antioxidants, Neuroprotective Agents

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Berberine prevents non-alcoholic steatohepatitis-derived hepatocellular carcinoma.Dec 31, 2018

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Pubmed Data : Am J Transl Res. 2019 ;11(5):2668-2682. Epub 2019 May 15. PMID: 31217846

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Berberine

Diseases : Liver Cancer, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors

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View the Evidence: 864 Abstracts with Berberine Research

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Neuroprotective effect and possible mechanisms of berberine in diabetes-related cognitive impairment.Dec 31, 2021

Pharmacological effects of berberine on models of ulcerative colitis.Dec 31, 2021

Protective effect of berberine in diabetic nephropathy.Oct 02, 2022

The effects of berberine supplementation on cardiovascular risk factors in adults.Dec 31, 2021

A nutraceutical combination has shown to be an effective product for the improvement of the lipid profile.Apr 26, 2016

Berberine and dyslipidemia: different applications and biopharmaceutical formulations without statin-like molecules.Aug 22, 2019

Berberine can improve obesity and hyperlipidemiaDec 31, 2020

Berberine exerted anti-tumor effects in a variety of tumors in vivo.Jun 16, 2019

Berberine showed a promising prospect in treating polycystic ovary syndrome patients with insulin resistance.Dec 31, 2017

Berberine supplementation may ameliorate the state of chronic inflammation.Sep 30, 2019

Efficacy and safety of berberine in preventing recurrence of colorectal adenomas.Sep 09, 2021

Systematic review and meta-analysis on efficacy and safety of berberine for dyslipidemiaJan 31, 2020

The addition of berberine in standard triple therapy could improve Helicobacter pylori eradication rate and clinical symptom remission rate.Dec 31, 2018

The effect of berberine on metabolic profiles in type 2 diabetic patients.Dec 31, 2020

The effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders.Mar 28, 2022

The results of the current study support the use of berberine supplementation for the improvement of obesity indices.Apr 30, 2020

These results found a significant reduction in waist-hip ratio following berberine consumption in adults.Feb 29, 2020

This meta-analysis found a significant reduction of body weight, BMI, WC and CRP levels associated with berberine intake.Jul 31, 2020

Berberine treats atherosclerosis via a vitamin-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota.Jan 06, 2022

A combination of berberine, red yeast rice and policosanol lowers lipid levels and improves endothelial function and insulin sensitivity in hypercholesterolemic patients. Aug 19, 2009

A nutraceutical formula containing berberine, chlorogenic acid, and tocotrienols was found to improve a large number of metabolic and liver parameters in overweight subjects.Mar 28, 2015

Berberine can represent a safe novel dietary supplement, helpful in treatment strategy for PCOS.Oct 18, 2021

Berberine Capsule was effective in improving blood lipid level in mild hyperlipidemia patients.May 31, 2016

Berberine containing quadruple therapy could be used for Helicobacter pylori eradication.Jul 31, 2017

Berberine exhibits antioxidative effects and reduces apoptosis of the vaginal epithelium in bacterial vaginosis.Aug 31, 2019

Berberine improves diabetic kidney disease by reducing UACR and serum Cys C in T2DM patients.Dec 10, 2018

Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy.Feb 01, 2007

Berberine is a potent oral hypoglycemic agent with benefical effects on lipid metabolism, comparable in efficacy to metformin. May 01, 2008

Berberine is a promising treatment for lowering cholesterol.Jul 25, 2021

Berberine is efficacious for the treatment of atrial fibrillation.Dec 31, 2016

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.Oct 06, 2009

Berberine possesses potential lipid-regulating, antiarthritis, and synovial hyperplasia inhibition activities against rheumatoid arthritis.Dec 31, 2018

Berberine promoted myocardial protection of postoperative patients through regulating myocardial autophagy.Aug 31, 2018

Berberine was safe and effective in reducing the risk of recurrence of colorectal adenoma.Jan 07, 2020

Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients.Dec 31, 2021

Dry extracts of artichoke and berberine have beneficial effects in hypercholesterolemic patients.Feb 14, 2019

Effect of berberine hydrochloride on the diversity of intestinal flora in Parkinson's disease patients.Dec 31, 2021

Effect of berberine on activation of TLR4-NFκB signaling pathway and NLRP3 inflammasome in patients with gout.Sep 19, 2022

Findings suggest that berberine is effective in attenuating antipsychotic-associated weight gain and MetS.Dec 20, 2021

Gut microbiota specifically mediates the anti-hypercholesterolemic effect of berberine.Dec 31, 2021

Hop rho iso-alpha acids, berberine, vitamin D(3) and vitamin K (1) favorably impact biomarkers of bone turnover in postmenopausal women. Dec 19, 2009

Improvement of adjunctive berberine treatment on negative symptoms in patients with schizophrenia.Jan 16, 2022

Role of a berberine-based nutritional supplement in reducing diarrhea in subjects with functional gastrointestinal disorders.Feb 29, 2020

The combined application of berberine in patients with metabolic syndrome can effectively regulate blood glucose and blood lipid of patients.Mar 31, 2019

The effect of berberine and fenugreek seed co-supplementation on inflammatory factor, lipid and glycemic profile in patients with type 2 diabetes mellitus.Aug 22, 2022

The potential prebiotic berberine combined with methimazole improved the therapeutic effect of Graves' disease patients.Dec 31, 2020

The role of serum inflammatory cytokines and berberine in the insulin signaling pathway among women with polycystic ovary syndrome.Dec 31, 2019

This study suggests that berberine is a potential weight loss and weight maintenance drug for patients with schizophrenia.Dec 31, 2021

Berberine alleviates myocardial ischemia-reperfusion injury.Nov 30, 2022

Berberine can significantly inhibit the activity of N-acetyltransferase in human lung cancer cell line A549.May 31, 2014

Berberine induced apoptosis and DNA damage in human osteosarcoma lines that were treated.Sep 30, 2014

Berberine may serve as a potential therapeutic option for patients with psoriasis.Mar 19, 2019

Berberine suppressed the progression of human glioma cells.Dec 31, 2021

Metabolomics profiling reveals berberine-inhibited inflammatory response in human gingival fibroblasts.Dec 31, 2021

These findings indicate that the protective effects of low-dose BBR against DOX-induced cardiotoxicity are mediated by Bcl-xL.Apr 29, 2022

These results suggest that berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokine profile in human preadipocytes and metabolic syndrome patients.Mar 07, 2012

Berberine inhibits tumour growth in vivo and in vitro through suppressing the lincROR-Wnt/β-catenin regulatory axis in colorectal cancer.Sep 20, 2022

Berberine protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition.Nov 30, 2022

Berberine up-regulates miR-340-5p to protect myocardial ischaemia/reperfusion.Nov 30, 2022

Immunomodulatory and anti-inflammatory effects of berberine in lung tissue and its potential application in prophylaxis and treatment of COVID-19.May 19, 2022

Macrophage-targeted berberine-loaded β-glucan nanoparticles enhance the treatment of ulcerative colitis.Dec 31, 2021

Remission of new-onset type 2 diabetes mellitus in an adolescent using an integrative medicine approach.Oct 21, 2020

The ameliorative effect of berberine on vascular calcification by inhibiting endoplasmic reticulum stress.May 15, 2022

Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.Dec 31, 2014

Berberine attenuates the abnormal ectopic lipid deposition in skeletal muscle.Jul 30, 2020

Berberine improves neointima formation in a rat model.May 01, 2006

Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3 Aug 19, 2021

A berberine derivative attenuates cardiac failure. Feb 01, 2010

A combination of baicalin and berberine hydrochloride ameliorates dextran sulfate sodium-induced colitis.Jul 31, 2022

A holistic view of berberine inhibiting intestinal carcinogenesis.Dec 31, 2019

A relatively low dose berberine exhibited strong neuroprotective activity against 6-OHDA-induced neurotoxicity in PC12 cells.Nov 03, 2016

Administration of Berberis vulgaris could ameliorate neurotoxicity induced by beta amyloid. Jul 04, 2015

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View the Evidence:
864 Abstracts with Berberine Research