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Berberine
Views 36597
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Focused Research Topics
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Click any topic below to filter + focus research
303 Diseases Researched for Berberine
Name
AC
CK
Focus
Insulin Resistance
23
92
Obesity
24
89
Diabetes Mellitus: Type 2
33
77
Inflammation
24
71
Hyperlipidemia
14
58
Dyslipidemias
3
41
C-Reactive Protein
2
40
Polycystic Ovary Syndrome
9
40
Breast Cancer
19
39
Cancers: All
18
38
Alzheimer's Disease
25
37
Helicobacter Pylori Infection
6
37
Lung Cancer
10
33
Nonalcoholic fatty liver disease (NAFLD)
17
31
Liver Cancer
20
25
Colorectal Cancer
10
24
Diabetic Complications
8
24
High Cholesterol
2
22
Hypercholesterolemia
3
22
Triglycerides: Elevated
2
22
Lipopolysaccharide-Induced Toxicity
14
21
Myocardial Ischemia
7
20
Colon Cancer
13
18
Osteoporosis
6
18
Rheumatoid Arthritis
8
18
Metabolic Diseases
6
17
Colitis
8
15
Diabetic Nephropathy
7
14
Atherosclerosis
8
13
Breast Cancer: Triple Negative
11
13
Cerebral Ischemia
7
13
High Fat Diet
7
13
Hyperglycemia
8
13
Ulcerative Colitis
8
13
Brain Inflammation
6
12
Depression
6
12
Endothelial Dysfunction
2
12
Fatty Liver
2
12
Kidney Diseases
2
12
Oxidative Stress
8
12
Diarrhea
2
11
Gastric Cancer
9
11
Glioblastoma
8
11
Atrial Fibrillation
1
10
Bacterial Vaginosis
1
10
Cognitive Decline/Dysfunction
5
10
Gastrointestinal Diseases
1
10
Osteosarcoma
5
10
Pancreatitis
6
10
Radiation Induced Illness
1
10
Sepsis
5
9
Cancers: Drug Resistant
7
8
Chemically-Induced Liver Damage
4
8
Heart Failure
5
8
Hypertension
5
8
Ischemia
5
8
Metabolic Syndrome X
4
8
Arthritis
4
7
Diabetes Mellitus: Type 1
4
7
Diabetes: Cognitive Dysfunction
4
7
Diabetic Neuropathy
4
7
Neurodegenerative Diseases
6
7
Carcinoma: Non-Small-Cell Lung
5
6
Cardiomyopathy
3
6
Cardiovascular Diseases
5
6
Epilepsy
3
6
Hypoxia
4
6
Melanoma
6
6
Ovarian Cancer
6
6
Autoimmune Diseases
3
5
Candida Albicans
5
5
Cervical Cancer
5
5
Chemotherapy-Induced Toxicity: Doxorubicin
3
5
Glioma
4
5
Influenza
3
5
Peripheral Neuropathies
3
5
Psoriasis
1
5
Acetaminophen (Tylenol) Toxicity
2
4
Advanced Glycation End products (AGE)
3
4
Alcohol Toxicity
2
4
Allergic Rhinitis
2
4
Asthma
3
4
Chemotherapy-Induced Toxicity: Paclitaxel
2
4
Chikungunya Virus
3
4
Enterocolitis: Necrotiziing
2
4
Fibrosis
2
4
Fructose-Induced Toxicity
2
4
Gastritis
2
4
Kidney Damage: Drug-Induced
2
4
Myocardial Infarction
2
4
Nasopharyngeal Cancer
3
4
Periodontitis
2
4
Prostatic Hyperplasia: Benign
2
4
Pseudomonas aeruginosa
3
4
Traumatic Brain Injury
2
4
Acute T cell Leukemias
3
3
Brain Ischemia
2
3
Brain: Oxidative Stress
2
3
Cancer Metastasis
3
3
Coxsackievirus Infections
2
3
Dementia
2
3
Diabetes: Oxidative Stress
2
3
Diabetic Retinopathy
3
3
Endometrial Cancer
2
3
Escherichia coli Infections
2
3
Hepatic Steatosis
2
3
Hydrogen Peroxide Induced Toxicity
3
3
Hypoglycemia
2
3
Leishmaniasis
2
3
Liver Fibrosis
2
3
Spinal Cord Injuries
2
3
Uveitis
2
3
Acute Respiratory Distress Syndrome
1
2
Adenomyosis
2
2
Aging
1
2
Aging: Brain
1
2
Alcoholic Liver Disease
1
2
Aluminum Toxicity
1
2
Aneurysm: Cerebral
1
2
Anxiety
1
2
Arsenic Poisoning
1
2
Arterial Hardening: Elasticity
1
2
Atopic Dermatitis
1
2
Autism
1
2
Bladder Dysfunction
1
2
Blood-Brain-Barrier Disorders
1
2
Bone Diseases
1
2
Brain Injury: Traumatic
1
2
Breast Cancer: Chemically-Induced
1
2
Bubonic Plague
1
2
Candida Infection
2
2
Cardiac Hypertrophy
1
2
Chemotherapy-Induced Toxicity: 5-fluorouracil
1
2
Chronic Myeloid Leukemia
1
2
Cocaine Withdrawal
1
2
Colon Cancer: Prevention
1
2
Colorectal Cancer: Prevention
1
2
Colorectal Tumors
1
2
Congestive Heart Failure
1
2
Convulsions
1
2
Coronavirus Infection
2
2
Cytomegalovirus Infections
2
2
Degenerative Disk Disease
2
2
Demyelinating Diseases
1
2
Diabesity
1
2
Diabetic Neuropathies
1
2
Diarrhea: Drug-Associated
1
2
Drug-Induced Toxicity: Gastrointestinal
1
2
Drug-Induced Toxicity: L-Thyroxine
1
2
Drug-Induced Toxicity: Methotrexate
1
2
Endothelial Damage
1
2
Erectile Dysfunction
1
2
Fetal Origin of Adult Disease
1
2
Gastric Polyposis
1
2
Gastrointestinal Inflammation
1
2
Graft vs Host Disease
1
2
HIV Infections
2
2
Heavy Metal Toxicity
1
2
Hepatitis: Autoimmune
1
2
High Homocysteine
1
2
Huntington Disease
1
2
Hyperalgesia
1
2
Hypersensitivity: Type IV
1
2
Hypertension: Pulmonary
1
2
Hypertension: Renal
1
2
Hyperuricemia
1
2
Immune Dysregulation: TH1 dominance
1
2
Immune Dysregulation: TH17 over-expression
1
2
Infertility: Male
1
2
Insomnia
1
2
Intestinal Permeability
1
2
Intestinal Polyps
1
2
Intima Media Thickening
1
2
Iron Overload
1
2
Irritable Bowel Syndrome
1
2
Kidney Fibrosis
1
2
Lead Poisoning
1
2
Learning disorders
1
2
Leukemia
2
2
Lipid Peroxidation
1
2
Liver Steatosis
1
2
Liver Stress: Fructose-Induced
1
2
Lung Cancer: Prevention
1
2
Malignant Melanoma
2
2
Mastitis
1
2
Memory Disorders: Drug-Induced
1
2
Middle Cerebral Artery Occlusion (MCAO)
1
2
Miscarriage
1
2
Morphine Tolerance/Dependence
1
2
Mucositis
1
2
Multiple Myeloma
2
2
Multiple Sclerosis
1
2
Muscle Damage: Exercise-Induced
1
2
Myocardial Fibrosis
1
2
Myocarditis: Viral
1
2
Nerve Injuries
1
2
Neuroblastoma
2
2
Neuropathic Pain
1
2
Non-Small-Cell Lung Carcinoma
2
2
Osteoarthritis
2
2
Pancreatic Cancer
2
2
Parkinson's Disease
1
2
Peripheral Nerve Diseases
1
2
Pesticide Toxicity
1
2
Post-Traumatic Stress Disorders (PTSD)
1
2
Postmenopausal Disorders
1
2
Postoperative Recovery
1
2
Prehypertension
1
2
Promyelocytic leukemia
2
2
Prostate Cancer
2
2
Psychiatric Disorders
1
2
Retinal Diseases
1
2
Schizophrenia
1
2
Seizures
1
2
Seizures: Drug-Induced
1
2
Smoking Cessation: Nicotine Addiction
1
2
Staphylococcal Infections
1
2
Staphylococcus aureus infection
2
2
Staphylococcus aureus: Methicillin-resistant (MRSA)
2
2
Stroke: Ischemic
1
2
Tongue Cancer
1
2
Uremia
1
2
Uveoretinitis
1
2
Varicocele
1
2
Acute Myeloid Leukemia
1
1
Acute lymphoblastic leukemia (ALL)
1
1
Allergic Airway Diseases
1
1
Allergies
1
1
Alphavirus Infections
1
1
Arthritis: Rheumatoid
1
1
Bacillus Cereus infection
1
1
Bacterial Infections and Mycoses
1
1
Bladder Cancer
1
1
Breast Cancer Stem Cells
1
1
Breast Cancer: HER-2 Overexpressed
1
1
Cancer: Virus-Induced
1
1
Cancers: Multi-Drug Resistant
1
1
Cardiac Arrhythmias
1
1
Chemotherapy-Induced Kidney Damage
1
1
Chemotherapy-Induced Toxicity: Cisplatin
1
1
Cholangiocarcinoma
1
1
Cholesterol: Oxidation
1
1
Chondrosarcoma
1
1
Chronic Disease
1
1
Chronic Kidney Disease (CKD)
1
1
Chronic Lymphocytic Leukemia
1
1
Chronic Obstructive Pulmonary Disease
1
1
Clostridium Infections
1
1
Corticosteroid-Induced Toxicity
1
1
Dementia: Senile
1
1
Dental Caries
1
1
Diabetes Mellitus: Type 2: Prevention
1
1
Diabetes: Glycation/A1C
1
1
Diabetes: Kidney Function
1
1
Diarrhea: in Children
1
1
Dysbiosis
1
1
Echinococcosis
1
1
Enterococcus Infections
1
1
Enterovirus 71
1
1
Enterovirus: Type 71
1
1
Esophageal Cancer
1
1
Eye Diseases
1
1
Friend Virus
1
1
Fungal Infection
1
1
Gastrointestinal Cancer
1
1
HIV Drug-Induced Toxicity
1
1
Head and Neck Cancer
1
1
Herpes Simplex Virus Type 1
1
1
Herpes Simplex Virus Type 2
1
1
High Sugar Diet
1
1
Human Papillomavirus (HPV)
1
1
Hydatid Cyst
1
1
Inflammatory Bowel Diseases
1
1
Kawasaki Disease
1
1
Kidney Cancer
1
1
Kidney Damage
1
1
Laryngeal Cancer
1
1
Leaky Gut Syndrome
1
1
Leukemia: Acute promyelocytic leukemia
1
1
Leukemia: Chronic Lymphocytic Leukemia (CLL)
1
1
Leukemia: Virus-Induced
1
1
Liver Damage
1
1
Lower Respiratory Infections
1
1
Lung Injury: Acute
1
1
Lymphangioendothelioma
1
1
Macular Degeneration
1
1
Mesothelioma
1
1
Microcystis aeruginosa
1
1
Myocarditis: Autoimmune
1
1
Oral Cancer
1
1
Overweight
1
1
Periodontal Diseases
1
1
Pulmonary Fibrosis
1
1
Respiratory Syncytial Virus Infections
1
1
Retinoblastoma
1
1
Rhabdomyosarcoma
1
1
Salmonella Infections
1
1
Skin Cancer: Squamous Cell
1
1
Squamous cell carcinoma
1
1
Streptococcus pyogenes
1
1
Subarachnoid hemorrhage
1
1
Thrombocytopenia
1
1
Thyroid Cancer
1
1
127 Pharmacological Actions Researched for Berberine
Name
AC
CK
Focus
Anti-Inflammatory Agents
134
266
Antiproliferative
79
116
Hypolipidemic
28
114
Antioxidants
64
107
Tumor Necrosis Factor (TNF) Alpha Inhibitor
45
99
Interleukin-6 Downregulation
43
93
Neuroprotective Agents
54
87
Apoptotic
62
72
Gastrointestinal Agents
25
71
Cardioprotective
28
64
Anticholesteremic Agents
9
60
Chemopreventive
23
59
Interleukin-1 beta downregulation
33
56
Hepatoprotective
29
54
Anti-Apoptotic
29
53
Hypoglycemic Agents
21
53
Anti-Bacterial Agents
12
42
NF-kappaB Inhibitor
28
41
MicroRNA modulator
27
39
Anti-metastatic
27
30
Renoprotective
16
27
Cell cycle arrest
23
26
Chemotherapeutic
22
24
Insulin Sensitizers
7
21
Chemosensitizer
18
19
Cyclooxygenase 2 Inhibitors
11
18
Autophagy Up-regulation
11
17
Gastroprotective
8
16
Immunomodulatory
12
16
Nrf2 activation
11
16
Antidiarrheals
4
14
Antineoplastic Agents
5
13
Antiviral Agents
11
13
Chemoprotective Agents
8
13
Anti-Fibrotic
7
12
Anticarcinogenic Agents
7
12
Matrix metalloproteinase-2 (MMP-2) inhibitor
10
12
Matrix metalloproteinase-9 (MMP-9) inhibitor
8
11
Antihypertensive Agents
6
10
Osteoprotective
6
10
Radioprotective
1
10
Antidepressive Agents
4
8
Antimicrobial
7
8
Interleukin-10 upregulation
4
8
Malondialdehyde Down-regulation
4
8
Pancreato Protective Agents
5
8
Tumor Suppressor Protein p53 Upregulation
7
8
Wnt/β-catenin signaling pathway modulation
7
8
Angiogenesis Inhibitors
5
7
Angiogenesis Inducing Agents
3
6
Anti-Adipogenic
5
6
Anti-Anxiety Agents
3
6
Anticonvulsants
3
6
Cytoprotective
4
6
Enzyme Inhibitors
2
6
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
5
6
Immunomodulatory: Th17 downregulation
3
6
STAT3 Inhibitor
4
5
Analgesics
2
4
Antifungal Agents
4
4
Bcl-2 protein down-regulation
4
4
Brain-derived neurotrophic factor modulator
2
4
Glucagon Like peptide 1 (GLP-1) Up-regulation
2
4
Heme oxygenase-1 up-regulation
3
4
Interleukin-10 downregulation
2
4
Interleukin-17 downregulation
2
4
Prostaglandin PGE2 downregulation
2
4
Radiosensitizer
3
4
Regenerative
3
4
Transforming growth factor beta (TGF-β) inhibitor
2
4
Vasoprotective
2
4
Anti-Glycation Agents
2
3
Anti-atherogenic
2
3
Caspase-3 Activation
2
3
Interleukin-8 downregulation
3
3
Matrix metalloproteinase-3 (MMP-3) inhibitor
2
3
Vascular Endothelial Growth Factor Inhibitors
3
3
Alpha-glucosidase inhibitor
2
2
Anti-Tumor
1
2
Bax/Bcl2 Ratio: Decrease
1
2
Caspase-9 Activation
1
2
Cholinesterase Inhibitors
1
2
Cytotoxic
2
2
Enzyme Inhibitors: Pancreatic Amylase
1
2
Enzyme Inhibitors: Pancreatic Lipase
1
2
Epidermal growth factor receptor (EGFR) inhibitor
1
2
Fertility Agents: Male
1
2
Fibroblast growth factor 21 upregulation
1
2
Immunosuppressive Agents
1
2
Interferon Gamma Reducer
1
2
Interleukin-1 alpha downregulation
2
2
Interleukin-4 downregulation
1
2
Interleukin-4 upregulation
1
2
Iron Chelating Agents
1
2
Leishmanicidal
1
2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
2
2
Neuritogenic
1
2
Nitric Oxide Inhibitor
1
2
P21 Activation
2
2
Photosensitizing Agents
2
2
SIRT1 Activator
1
2
Uricosuric Agents
1
2
Wnt/β-catenin pathway down-regulation
1
2
interleukin-13 down-regulation
1
2
AMP-activated protein kinase modulation
1
1
Acetylcholinesterase Inhibitor
1
1
Alpha-amylase inhibitor
1
1
Anti-Allergic Agents
1
1
Anti-Androgen
1
1
Anti-Proliferative
1
1
Antioxidant Effects
1
1
Autophagy Inhibitors
1
1
Cyclin D1 Down-Regulation
1
1
Cyclin-dependent kinase inhibitor: P16INK4
1
1
Expectorants
1
1
Gluconeogenesis Inhibitor
1
1
HIV Protease Inhibitors
1
1
Interleukin-18 down-regulation
1
1
Matrix metalloproteinase-1 (MMP-1) inhibitor
1
1
Multidrug Resistance Gene Modulators
1
1
Osteogenic
1
1
P38 Mitogen-Activated Protein Kinase Modulator
1
1
Prophylactic Agents
1
1
RANK Downregulation
1
1
Scolicidal
1
1
Survivin Down-Regulation
1
1
Telomerase Inhibitor
1
1
Research Articles
627
Cumulative Knowledge Score
1014
Overall Research Rating
EXCELLENT
View the Evidence:
827 Abstracts with Berberine Research
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[+]
Neuroprotective effect and possible mechanisms of berberine in diabetes-related cognitive impairment.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2022 ;13:917375. Epub 2022 Jun 6. PMID:
35734409
Article Published Date
: Dec 31, 2021
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes: Cognitive Dysfunction
Pharmacological Actions
:
Acetylcholinesterase Inhibitor
,
Anti-Inflammatory Agents
,
Antioxidants
,
Hypoglycemic Agents
,
Hypolipidemic
,
Neuroprotective Agents
[+]
A nutraceutical combination has shown to be an effective product for the improvement of the lipid profile.
Apr 26, 2016
Click here to read the entire abstract
Pubmed Data
: Clin Investig Arterioscler. 2016 Apr 27. Epub 2016 Apr 27. PMID:
27131395
Article Published Date
: Apr 26, 2016
Study Type
: Meta Analysis
Additional Links
Substances
:
Berberine
,
Policosanol
,
Red Yeast Rice
Diseases
:
High Cholesterol
,
Hyperlipidemia
,
Triglycerides: Elevated
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
[+]
Berberine and dyslipidemia: different applications and biopharmaceutical formulations without statin-like molecules.
Aug 22, 2019
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2019 Aug 23. Epub 2019 Aug 23. PMID:
31441678
Article Published Date
: Aug 22, 2019
Study Type
: Meta Analysis
Additional Links
Substances
:
Berberine
Diseases
:
Dyslipidemias
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
[+]
Berberine can improve obesity and hyperlipidemia
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2021 ;12:653887. Epub 2021 Apr 26. PMID:
33981233
Article Published Date
: Dec 31, 2020
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Berberine
Diseases
:
Hyperlipidemia
,
Obesity
Pharmacological Actions
:
Hypolipidemic
Additional Keywords
:
Anti-Obesity Agents
[+]
Berberine exerted anti-tumor effects in a variety of tumors in vivo.
Jun 16, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Cancer. 2019 Jun 17 ;19(1):589. Epub 2019 Jun 17. PMID:
31208348
Article Published Date
: Jun 16, 2019
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Berberine
Diseases
:
Breast Cancer
,
Cancers: All
,
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Chemopreventive
[+]
Berberine showed a promising prospect in treating polycystic ovary syndrome patients with insulin resistance.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2018 ;2018:2532935. Epub 2018 Nov 14. PMID:
30538756
Article Published Date
: Dec 31, 2017
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Berberine
Diseases
:
Insulin Resistance
,
Polycystic Ovary Syndrome
[+]
Berberine supplementation may ameliorate the state of chronic inflammation.
Sep 30, 2019
Click here to read the entire abstract
Pubmed Data
: Complement Ther Med. 2019 Oct ;46:81-86. Epub 2019 Aug 4. PMID:
31519292
Article Published Date
: Sep 30, 2019
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Berberine
Diseases
:
C-Reactive Protein
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Efficacy and safety of berberine in preventing recurrence of colorectal adenomas.
Sep 09, 2021
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2021 Sep 10 ;282:114617. Epub 2021 Sep 10. PMID:
34509605
Article Published Date
: Sep 09, 2021
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Chemopreventive
[+]
Systematic review and meta-analysis on efficacy and safety of berberine for dyslipidemia
Jan 31, 2020
Click here to read the entire abstract
Pubmed Data
: Zhongguo Zhong Yao Za Zhi. 2020 Feb ;45(3):664-673. PMID:
32237527
Article Published Date
: Jan 31, 2020
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Berberine
Diseases
:
Dyslipidemias
Pharmacological Actions
:
Gastrointestinal Agents
[+]
The addition of berberine in standard triple therapy could improve Helicobacter pylori eradication rate and clinical symptom remission rate.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2019 ;10:1694. Epub 2020 Feb 4. PMID:
32116685
Article Published Date
: Dec 31, 2018
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Berberine
Diseases
:
Helicobacter Pylori Infection
Pharmacological Actions
:
Anti-Bacterial Agents
[+]
The effect of berberine on metabolic profiles in type 2 diabetic patients.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2021 ;2021:2074610. Epub 2021 Dec 15. PMID:
34956436
Article Published Date
: Dec 31, 2020
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hypolipidemic
[+]
The effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders.
Mar 28, 2022
Click here to read the entire abstract
Pubmed Data
: Inflammopharmacology. 2022 Mar 29. Epub 2022 Mar 29. PMID:
35352233
Article Published Date
: Mar 28, 2022
Study Type
: Meta Analysis
Additional Links
Substances
:
Berberine
Diseases
:
Metabolic Syndrome X
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
The results of the current study support the use of berberine supplementation for the improvement of obesity indices.
Apr 30, 2020
Click here to read the entire abstract
Pubmed Data
: Complement Ther Clin Pract. 2020 May ;39:101113. Epub 2020 Feb 1. PMID:
32379652
Article Published Date
: Apr 30, 2020
Study Type
: Meta Analysis
Additional Links
Substances
:
Berberine
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
These results found a significant reduction in waist-hip ratio following berberine consumption in adults.
Feb 29, 2020
Click here to read the entire abstract
Pubmed Data
: Complement Ther Med. 2020 Mar ;49:102337. Epub 2020 Feb 3. PMID:
32147051
Article Published Date
: Feb 29, 2020
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Barberry
,
Berberine
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
This meta-analysis found a significant reduction of body weight, BMI, WC and CRP levels associated with berberine intake.
Jul 31, 2020
Click here to read the entire abstract
Pubmed Data
: Clin Nutr ESPEN. 2020 Aug ;38:43-49. Epub 2020 May 6. PMID:
32690176
Article Published Date
: Jul 31, 2020
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Berberine
Diseases
:
C-Reactive Protein
,
Inflammation
,
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
Berberine treats atherosclerosis via a vitamin-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota.
Jan 06, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Signal Transduct Target Ther. 2022 07 7 ;7(1):207. Epub 2022 Jul 7. PMID:
35794102
Article Published Date
: Jan 06, 2022
Study Type
: Animal Study, Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Gastrointestinal Agents
[+]
A combination of berberine, red yeast rice and policosanol lowers lipid levels and improves endothelial function and insulin sensitivity in hypercholesterolemic patients.
Aug 19, 2009
Click here to read the entire abstract
Pubmed Data
: Nutr Metab Cardiovasc Dis. 2009 Aug 19. Epub 2009 Aug 19. PMID:
19699071
Article Published Date
: Aug 19, 2009
Study Type
: Human Study
Additional Links
Substances
:
Berberine
,
Policosanol
,
Red Yeast Rice
Diseases
:
Endothelial Dysfunction
,
Hypercholesterolemia
,
Insulin Resistance
[+]
A nutraceutical formula containing berberine, chlorogenic acid, and tocotrienols was found to improve a large number of metabolic and liver parameters in overweight subjects.
Mar 28, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Nutr J. 2015 Mar 28 ;14:30. Epub 2015 Mar 28. PMID:
25886384
Article Published Date
: Mar 28, 2015
Study Type
: Human Study
Additional Links
Substances
:
Berberine
,
Chlorogenic Acid
,
Tocotrienols
Diseases
:
Fatty Liver
,
Hyperlipidemia
,
Insulin Resistance
Problem Substances
:
Insulin
[+]
Berberine can represent a safe novel dietary supplement, helpful in treatment strategy for PCOS.
Oct 18, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2021 Oct 19 ;13(10). Epub 2021 Oct 19. PMID:
34684666
Article Published Date
: Oct 18, 2021
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Polycystic Ovary Syndrome
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Insulin Sensitizers
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine Capsule was effective in improving blood lipid level in mild hyperlipidemia patients.
May 31, 2016
Click here to read the entire abstract
Pubmed Data
: Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Jun ;36(6):681-4. PMID:
27491226
Article Published Date
: May 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Hyperlipidemia
Pharmacological Actions
:
Hypolipidemic
[+]
Berberine containing quadruple therapy could be used for Helicobacter pylori eradication.
Jul 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Medicine (Baltimore). 2017 Aug ;96(32):e7697. PMID:
28796053
Article Published Date
: Jul 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Helicobacter Pylori Infection
Pharmacological Actions
:
Anti-Bacterial Agents
[+]
Berberine exhibits antioxidative effects and reduces apoptosis of the vaginal epithelium in bacterial vaginosis.
Aug 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2019 Sep ;18(3):2122-2130. Epub 2019 Jul 12. PMID:
31410167
Article Published Date
: Aug 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Bacterial Vaginosis
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
[+]
Berberine improves diabetic kidney disease by reducing UACR and serum Cys C in T2DM patients.
Dec 10, 2018
Click here to read the entire abstract
Pubmed Data
: Zhonghua Yi Xue Za Zhi. 2018 Dec 11 ;98(46):3756-3761. PMID:
30541217
Article Published Date
: Dec 10, 2018
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Complications
,
Kidney Diseases
[+]
Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy.
Feb 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Forensic Leg Med. 2007 Feb;14(2):87-91. PMID:
19757213
Article Published Date
: Feb 01, 2007
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Radiation Induced Illness
Pharmacological Actions
:
Radioprotective
Anti Therapeutic Actions
:
Radiotherapy
[+]
Berberine is a potent oral hypoglycemic agent with benefical effects on lipid metabolism, comparable in efficacy to metformin.
May 01, 2008
Click here to read the entire abstract
Pubmed Data
: Metabolism. 2008 May;57(5):712-7. PMID:
18442638
Article Published Date
: May 01, 2008
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Additional Keywords
:
Drug: Metformin
,
Metformin Alternatives
,
Natural Substances Versus Drugs
[+]
Berberine is a promising treatment for lowering cholesterol.
Jul 25, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2021 Jul 26 ;13(8). Epub 2021 Jul 26. PMID:
34444711
Article Published Date
: Jul 25, 2021
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Cardiovascular Diseases
Pharmacological Actions
:
Anticholesteremic Agents
[+]
Berberine is efficacious for the treatment of atrial fibrillation.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2017 ;2017:3146791. Epub 2017 Dec 17. PMID:
29392132
Article Published Date
: Dec 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Atrial Fibrillation
Pharmacological Actions
:
Cardioprotective
[+]
Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.
Oct 06, 2009
Click here to read the entire abstract
Pubmed Data
: Evid Based Complement Alternat Med. 2009 Oct 6; PMID:
19800084
Article Published Date
: Oct 06, 2009
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Hypoglycemic Agents
Additional Keywords
:
Drug: Metformin
,
Drug: Rosiglitazone
,
Insulin Receptor Upregulation
,
Natural Substances Versus Drugs
[+]
Berberine possesses potential lipid-regulating, antiarthritis, and synovial hyperplasia inhibition activities against rheumatoid arthritis.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2019 ;2019:2580207. Epub 2019 Nov 3. PMID:
31781264
Article Published Date
: Dec 31, 2018
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hypolipidemic
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine promoted myocardial protection of postoperative patients through regulating myocardial autophagy.
Aug 31, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Sep ;105:1050-1053. Epub 2018 Jun 19. PMID:
30021340
Article Published Date
: Aug 31, 2018
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine was safe and effective in reducing the risk of recurrence of colorectal adenoma.
Jan 07, 2020
Click here to read the entire abstract
Pubmed Data
: Lancet Gastroenterol Hepatol. 2020 Jan 8. Epub 2020 Jan 8. PMID:
31926918
Article Published Date
: Jan 07, 2020
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Risk Reduction
[+]
Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Gut Microbes. 2022 Jan-Dec;14(1):2003176. PMID:
34923903
Article Published Date
: Dec 31, 2021
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Gastrointestinal Agents
,
Hypolipidemic
[+]
Dry extracts of artichoke and berberine have beneficial effects in hypercholesterolemic patients.
Feb 14, 2019
Click here to read the entire abstract
Pubmed Data
: Am J Cardiol. 2019 Feb 15 ;123(4):588-591. Epub 2018 Nov 23. PMID:
30528419
Article Published Date
: Feb 14, 2019
Study Type
: Human Study
Additional Links
Substances
:
Artichoke
,
Berberine
Diseases
:
Hypercholesterolemia
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
[+]
Effect of berberine hydrochloride on the diversity of intestinal flora in Parkinson's disease patients.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Contrast Media Mol Imaging. 2022 ;2022:8381870. Epub 2022 May 30. PMID:
35685661
Article Published Date
: Dec 31, 2021
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Parkinson's Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Gastrointestinal Agents
,
Interleukin-6 Downregulation
,
Interleukin-8 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Findings suggest that berberine is effective in attenuating antipsychotic-associated weight gain and MetS.
Dec 20, 2021
Click here to read the entire abstract
Pubmed Data
: Psychiatry Clin Neurosci. 2021 Dec 21. Epub 2021 Dec 21. PMID:
34931749
Article Published Date
: Dec 20, 2021
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Schizophrenia
,
Weight Gain: Drug-Induced
Additional Keywords
:
Anti-Obesity Agents
[+]
Gut microbiota specifically mediates the anti-hypercholesterolemic effect of berberine.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Adv Res. 2022 03 ;37:197-208. Epub 2021 Jul 30. PMID:
35499044
Article Published Date
: Dec 31, 2021
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Hypercholesterolemia
,
Hyperlipidemia
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
[+]
Hop rho iso-alpha acids, berberine, vitamin D(3) and vitamin K (1) favorably impact biomarkers of bone turnover in postmenopausal women.
Dec 19, 2009
Click here to read the entire abstract
Pubmed Data
: J Bone Miner Metab. 2009 Dec 19. Epub 2009 Dec 19. PMID:
20024591
Article Published Date
: Dec 19, 2009
Study Type
: Human Study
Additional Links
Substances
:
Berberine
,
Hops
,
Vitamin D
,
Vitamin K
Diseases
:
Osteoporosis
[+]
Improvement of adjunctive berberine treatment on negative symptoms in patients with schizophrenia.
Jan 16, 2022
Click here to read the entire abstract
Pubmed Data
: Eur Arch Psychiatry Clin Neurosci. 2022 Jan 17. Epub 2022 Jan 17. PMID:
35037116
Article Published Date
: Jan 16, 2022
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Schizophrenia
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Role of a berberine-based nutritional supplement in reducing diarrhea in subjects with functional gastrointestinal disorders.
Feb 29, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Minerva Gastroenterol Dietol. 2020 Mar ;66(1):29-34. PMID:
32283882
Article Published Date
: Feb 29, 2020
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Diarrhea
,
Gastrointestinal Diseases
Pharmacological Actions
:
Antidiarrheals
,
Gastrointestinal Agents
[+]
The combined application of berberine in patients with metabolic syndrome can effectively regulate blood glucose and blood lipid of patients.
Mar 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2019 Apr ;17(4):3009-3014. Epub 2019 Feb 22. PMID:
30936971
Article Published Date
: Mar 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
,
Insulin Resistance
,
Metabolic Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hypoglycemic Agents
,
Hypolipidemic
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
The effect of berberine and fenugreek seed co-supplementation on inflammatory factor, lipid and glycemic profile in patients with type 2 diabetes mellitus.
Aug 22, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Diabetol Metab Syndr. 2022 Aug 23 ;14(1):120. Epub 2022 Aug 23. PMID:
35999562
Article Published Date
: Aug 22, 2022
Study Type
: Human Study
Additional Links
Substances
:
Berberine
,
Fenugreek
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hypolipidemic
[+]
The potential prebiotic berberine combined with methimazole improved the therapeutic effect of Graves' disease patients.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Front Immunol. 2021 ;12:826067. Epub 2022 Jan 10. PMID:
35082799
Article Published Date
: Dec 31, 2020
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Graves Disease
Pharmacological Actions
:
Gastrointestinal Agents
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
The role of serum inflammatory cytokines and berberine in the insulin signaling pathway among women with polycystic ovary syndrome.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: PLoS One. 2020 ;15(8):e0235404. Epub 2020 Aug 12. PMID:
32785222
Article Published Date
: Dec 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Insulin Resistance
,
Polycystic Ovary Syndrome
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Insulin Sensitizers
[+]
This study suggests that berberine is a potential weight loss and weight maintenance drug for patients with schizophrenia.
Dec 31, 2021
Click here to read the entire abstract
Pubmed Data
: Asian J Psychiatr. 2022 Jan ;67:102896. Epub 2021 Nov 1. PMID:
34773803
Article Published Date
: Dec 31, 2021
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Schizophrenia
,
Weight Gain: Drug-Induced
Additional Keywords
:
Anti-Obesity Agents
[+]
Berberine alleviates myocardial ischemia-reperfusion injury.
Nov 30, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharm Biol. 2022 Dec ;60(1):652-663. PMID:
35311466
Article Published Date
: Nov 30, 2022
Study Type
: Human In Vitro
Additional Links
Substances
:
Berberine
Diseases
:
Inflammation
,
Myocardial Ischemia
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Cardioprotective
,
Cyclooxygenase 2 Inhibitors
[+]
Berberine can significantly inhibit the activity of N-acetyltransferase in human lung cancer cell line A549.
May 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: J Tradit Chin Med. 2014 Jun ;34(3):302-8. PMID:
24992757
Article Published Date
: May 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Berberine
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Enzyme Inhibitors
,
MicroRNA modulator
Additional Keywords
:
Chinese Herbs
,
Gene Expression Regulation
[+]
Berberine induced apoptosis and DNA damage in human osteosarcoma lines that were treated.
Sep 30, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Mol Med Rep. 2014 Oct ;10(4):1734-8. Epub 2014 Jul 21. PMID:
25050485
Article Published Date
: Sep 30, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Berberine
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
[+]
Berberine may serve as a potential therapeutic option for patients with psoriasis.
Mar 19, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Death Dis. 2019 Mar 20 ;10(4):274. Epub 2019 Mar 20. PMID:
30894513
Article Published Date
: Mar 19, 2019
Study Type
: Human In Vitro
Additional Links
Substances
:
Berberine
Diseases
:
Psoriasis
Pharmacological Actions
:
Antiproliferative
[+]
Metabolomics profiling reveals berberine-inhibited inflammatory response in human gingival fibroblasts.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Front Pharmacol. 2022 ;13:940224. Epub 2022 Aug 22. PMID:
36071855
Article Published Date
: Dec 31, 2021
Study Type
: Human In Vitro
Additional Links
Substances
:
Berberine
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
These findings indicate that the protective effects of low-dose BBR against DOX-induced cardiotoxicity are mediated by Bcl-xL.
Apr 29, 2022
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2022 Apr 30 ;101:154130. Epub 2022 Apr 30. PMID:
35526324
Article Published Date
: Apr 29, 2022
Study Type
: Human In Vitro
Additional Links
Substances
:
Berberine
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Cardioprotective
,
Chemoprotective Agents
[+]
These results suggest that berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokine profile in human preadipocytes and metabolic syndrome patients.
Mar 07, 2012
Click here to read the entire abstract
Pubmed Data
: Evid Based Complement Alternat Med. 2012 ;2012:363845. Epub 2012 Mar 8. PMID:
22474499
Article Published Date
: Mar 07, 2012
Study Type
: Human In Vitro
Additional Links
Substances
:
Berberine
Diseases
:
Insulin Resistance
,
Metabolic Syndrome X
Pharmacological Actions
:
Insulin Sensitizers
[+]
Berberine protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition.
Nov 30, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Ren Fail. 2022 Dec ;44(1):923-932. PMID:
35618411
Article Published Date
: Nov 30, 2022
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Immunomodulatory and anti-inflammatory effects of berberine in lung tissue and its potential application in prophylaxis and treatment of COVID-19.
May 19, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Front Biosci (Landmark Ed). 2022 May 20 ;27(5):166. PMID:
35638433
Article Published Date
: May 19, 2022
Study Type
: Review
Additional Links
Substances
:
Berberine
Diseases
:
Coronavirus Infection
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Immunomodulatory
,
Prophylactic Agents
Additional Keywords
:
Cytokine Storm
[+]
Remission of new-onset type 2 diabetes mellitus in an adolescent using an integrative medicine approach.
Oct 21, 2020
Click here to read the entire abstract
Pubmed Data
: J Integr Med. 2020 Oct 22. Epub 2020 Oct 22. PMID:
33162376
Article Published Date
: Oct 21, 2020
Study Type
: Human: Case Report
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Therapeutic Actions
:
Exercise
Additional Keywords
:
Risk Reduction
[+]
The ameliorative effect of berberine on vascular calcification by inhibiting endoplasmic reticulum stress.
May 15, 2022
Click here to read the entire abstract
Pubmed Data
: J Cardiovasc Pharmacol. 2022 May 16. Epub 2022 May 16. PMID:
35580317
Article Published Date
: May 15, 2022
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Vascular Calcification
Pharmacological Actions
:
Vasoprotective
[+]
Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(5):e0123478. Epub 2015 May 8. PMID:
25954974
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Prostaglandin PGE2 downregulation
[+]
Berberine attenuates the abnormal ectopic lipid deposition in skeletal muscle.
Jul 30, 2020
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2020 Jul 31. Epub 2020 Jul 31. PMID:
32745766
Article Published Date
: Jul 30, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hyperlipidemia
,
Obesity
Pharmacological Actions
:
Hypolipidemic
[+]
Berberine improves neointima formation in a rat model.
May 01, 2006
Click here to read the entire abstract
Pubmed Data
: Atherosclerosis. 2006 May;186(1):29-37. Epub 2005 Aug 10. PMID:
16098530
Article Published Date
: May 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Atherosclerosis
,
Intima Media Thickening
[+]
Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3
Aug 19, 2021
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2021 Aug 20. Epub 2021 Aug 20. PMID:
34417576
Article Published Date
: Aug 19, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Metabolic Diseases
,
Obesity
Pharmacological Actions
:
Hepatoprotective
,
Hypoglycemic Agents
,
Hypolipidemic
Additional Keywords
:
Anti-Obesity Agents
[+]
A berberine derivative attenuates cardiac failure.
Feb 01, 2010
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2010 Feb;31(2):165-74. PMID:
20139899
Article Published Date
: Feb 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Heart Failure
,
Myocardial Infarction
Pharmacological Actions
:
Antioxidants
[+]
A combination of baicalin and berberine hydrochloride ameliorates dextran sulfate sodium-induced colitis.
Jul 31, 2022
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2022 Aug ;25(8):853-862. PMID:
35980327
Article Published Date
: Jul 31, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Flavonoids
Diseases
:
Colitis
,
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Gastrointestinal Agents
,
Interleukin-6 Downregulation
,
Interleukin-8 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
A holistic view of berberine inhibiting intestinal carcinogenesis.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Immunol. 2020 ;11:588079. Epub 2020 Sep 24. PMID:
33072135
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
[+]
A relatively low dose berberine exhibited strong neuroprotective activity against 6-OHDA-induced neurotoxicity in PC12 cells.
Nov 03, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Redox Biol. 2016 Nov 4 ;11:1-11. Epub 2016 Aug 4. PMID:
27835779
Article Published Date
: Nov 03, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Parkinson's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Administration of Berberis vulgaris could ameliorate neurotoxicity induced by beta amyloid.
Jul 04, 2015
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2015 Jul 5 ;758:82-8. Epub 2015 Apr 8. PMID:
25861937
Article Published Date
: Jul 04, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Barberry
,
Berberine
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Ameliorating effects of berberine on MK-801-induced cognitive and motor impairments in a neonatal rat model of schizophrenia.
May 15, 2019
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2019 May 16. Epub 2019 May 16. PMID:
31103726
Article Published Date
: May 15, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Schizophrenia
Pharmacological Actions
:
Neuroprotective Agents
[+]
Ameliorating ribosylation-induced amyloid-β pathology by berberine.
Dec 22, 2020
Click here to read the entire abstract
Pubmed Data
: J Alzheimers Dis. 2020 Dec 23. Epub 2020 Dec 23. PMID:
33361598
Article Published Date
: Dec 22, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Ameliorative effect of berberine on neonatally induced type 2 diabetic neuropathy.
Jun 30, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Dose Response. 2019 Jul-Sep;17(3):1559325819862449. Epub 2019 Jul 16. PMID:
31360147
Article Published Date
: Jun 30, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Neuropathy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
An inhibitory effect of Berberine from herbal Coptis chinensis Franch on rat detrusor contraction in benign prostatic hyperplasia associated with lower urinary tract symptoms.
Dec 06, 2020
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2020 Dec 7 ;268:113666. Epub 2020 Dec 7. PMID:
33301912
Article Published Date
: Dec 06, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Bladder Dysfunction
,
Prostatic Hyperplasia: Benign
[+]
Anti-inflammation associated protective mechanism of berberine and its derivatives on attenuating pentylenetetrazole-induced seizures.
Jan 05, 2020
Click here to read the entire abstract
Pubmed Data
: J Neuroimmune Pharmacol. 2020 Jan 6. Epub 2020 Jan 6. PMID:
31909440
Article Published Date
: Jan 05, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Epilepsy
,
Seizures: Drug-Induced
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticonvulsants
[+]
Anti-inflammatory efficacy of berberine nanomicelle for improvement of cerebral ischemia.
Jan 02, 2021
Click here to read the entire abstract
Pubmed Data
: BMC Pharmacol Toxicol. 2021 10 3 ;22(1):54. Epub 2021 Oct 3. PMID:
34600570
Article Published Date
: Jan 02, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
Anti-influenza activity of berberine improves prognosis by reducing viral replication in mice.
Oct 10, 2018
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2018 Oct 11. Epub 2018 Oct 11. PMID:
30306659
Article Published Date
: Oct 10, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Influenza
Pharmacological Actions
:
Antiviral Agents
[+]
Anticolitic effect of berberine in rat experimental model.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mediators Inflamm. 2020 ;2020:9419085. Epub 2020 Sep 29. PMID:
33061833
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis.
Aug 20, 2018
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2018 Aug 21 ;294:91-100. Epub 2018 Aug 21. PMID:
30138605
Article Published Date
: Aug 20, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Liver Fibrosis
Pharmacological Actions
:
Anti-Fibrotic
,
Hepatoprotective
[+]
Autologous erythrocytes delivery of berberine hydrochloride with long-acting effect for hypolipidemia treatment.
Nov 30, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Deliv. 2020 Dec ;27(1):283-291. PMID:
32013620
Article Published Date
: Nov 30, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hyperlipidemia
Pharmacological Actions
:
Hypolipidemic
[+]
Berbamine and thymoquinone exert protective effects against immune-mediated liver injury.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Vet Sci. 2022 ;9:960981. Epub 2022 Jul 26. PMID:
35958317
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Thymoquinone
Diseases
:
Hepatitis: Lectin-Induced (concanavalin)
,
Liver Damage
Pharmacological Actions
:
Hepatoprotective
Problem Substances
:
Concanavalin A
[+]
Berbamine induces programmed cell death in human liver cancer cells and inhibits tumor growth in mice.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Asian Nat Prod Res. 2009;11(3):219-28. PMID:
19408145
Article Published Date
: Jan 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Liver Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Berberine (a major constituent of goldenseal) has significant cholesterol-lowering action
Dec 01, 2004
Click here to read the entire abstract
Pubmed Data
: Nat Med. 2004 Dec;10(12):1344-51. Epub 2004 Nov 7. PMID:
15531889
Article Published Date
: Dec 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hypercholesterolemia
[+]
Berberine activates apoptosis to suppress triple-negative breast cancer cells.
Aug 17, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Aug 18 ;95:18-24. Epub 2017 Aug 18. PMID:
28826092
Article Published Date
: Aug 17, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Breast Cancer: Triple Negative
Pharmacological Actions
:
Apoptotic
,
Caspase-3 Activation
,
Caspase-9 Activation
[+]
Berberine alleviated doxorubicin induced cardiotoxicity via inhibition of the metabolism of doxorubicin and reduced accumulation of doxorubicinol selectively in hearts.
May 12, 2015
Click here to read the entire abstract
Pubmed Data
: Xenobiotica. 2015 May 13:1-6. Epub 2015 May 13. PMID:
25970816
Article Published Date
: May 12, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Cardioprotective
,
Chemoprotective Agents
[+]
Berberine alleviates adipose tissue fibrosis.
May 27, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 May 28 ;105:121-129. Epub 2018 May 28. PMID:
29852389
Article Published Date
: May 27, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Fibrosis
,
Obesity
Pharmacological Actions
:
Anti-Fibrotic
[+]
Berberine alleviates amyloid-beta pathogenesis.
Mar 14, 2019
Click here to read the entire abstract
Pubmed Data
: Curr Mol Med. 2019 Mar 15. Epub 2019 Mar 15. PMID:
30873920
Article Published Date
: Mar 14, 2019
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine alleviates amyloid-beta pathology in the brain of APP/PS1 transgenic mice.
Jun 30, 2018
Click here to read the entire abstract
Pubmed Data
: Curr Alzheimer Res. 2018 Jul 1. Epub 2018 Jul 1. PMID:
29962345
Article Published Date
: Jun 30, 2018
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine alleviates dextran sodium sulfate-induced colitis.
May 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2017 Jun ;13(6):3374-3382. Epub 2017 Apr 28. PMID:
28587416
Article Published Date
: May 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
Berberine alleviates disease symptoms in mouse models mimicking the symptoms of IBS-D.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(12):e0145556. Epub 2015 Dec 23. PMID:
26700862
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Irritable Bowel Syndrome
Pharmacological Actions
:
Analgesics
,
MicroRNA modulator
[+]
Berberine alleviates endothelial glycocalyx degradation and promotes glycocalyx restoration in LPS-induced ARDS.
Oct 07, 2018
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2018 Oct 8 ;65:96-107. Epub 2018 Oct 8. PMID:
30308440
Article Published Date
: Oct 07, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Acute Respiratory Distress Syndrome
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine alleviates hepatic lipid accumulation.
Mar 01, 2018
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2018 Mar 2. Epub 2018 Mar 2. PMID:
29505790
Article Published Date
: Mar 01, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
,
Hypolipidemic
[+]
Berberine alleviates hyperglycemia by targeting hepatic glucokinase.
May 28, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2019 May 29 ;9(1):8003. Epub 2019 May 29. PMID:
31142783
Article Published Date
: May 28, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hyperglycemia
Pharmacological Actions
:
Hypoglycemic Agents
[+]
Berberine alleviates lipid metabolism disorders via inhibition of mitochondrial complex I in gut and liver.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Biol Sci. 2021 ;17(7):1693-1707. Epub 2021 Apr 12. PMID:
33994854
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hyperlipidemia
Pharmacological Actions
:
Hypolipidemic
[+]
Berberine alleviates monosodium glutamate induced postnatal metabolic disorders associated vascular endothelial dysfunction.
Feb 18, 2020
Click here to read the entire abstract
Pubmed Data
: Arch Physiol Biochem. 2020 Feb 19:1-12. Epub 2020 Feb 19. PMID:
32072839
Article Published Date
: Feb 18, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Endothelial Dysfunction
,
Inflammation
Pharmacological Actions
:
Vasoprotective
Problem Substances
:
Monosodium Glutamate (MSG)
[+]
Berberine alleviates NASH and its predisposing factors.
Feb 29, 2016
Click here to read the entire abstract
Pubmed Data
: Arch Iran Med. 2016 Mar ;19(3):197-203. PMID:
26923892
Article Published Date
: Feb 29, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hypoglycemic Agents
,
Hypolipidemic
Additional Keywords
:
Microbiota
[+]
Berberine alleviates NLRP3 inflammasome induced endothelial junction dysfunction.
Apr 25, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Phytomedicine. 2022 Apr 26 ;101:154131. Epub 2022 Apr 26. PMID:
35533609
Article Published Date
: Apr 25, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cardiovascular Diseases
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Berberine alleviates non-alcoholic steatohepatitis through modulating gut microbiota mediated intestinal FXR activation.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2021 ;12:750826. Epub 2021 Sep 17. PMID:
34603061
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Gastrointestinal Agents
[+]
Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3.
Mar 07, 2019
Click here to read the entire abstract
Pubmed Data
: FASEB J. 2019 Mar 8:fj201802316R. Epub 2019 Mar 8. PMID:
30848932
Article Published Date
: Mar 07, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
[+]
Berberine alleviates oxidative stress in islets of diabetic mice.
Apr 23, 2017
Click here to read the entire abstract
Pubmed Data
: J Cell Biochem. 2017 Apr 24. Epub 2017 Apr 24. PMID:
28436095
Article Published Date
: Apr 23, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes: Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
MicroRNA modulator
,
SIRT1 Activator
[+]
Berberine alleviates oxidative stress in rats with osteoporosis.
Oct 21, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Bosn J Basic Med Sci. 2017 Oct 22. Epub 2017 Oct 22. PMID:
29055350
Article Published Date
: Oct 21, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Osteoporosis
Pharmacological Actions
:
Antioxidants
,
Osteoprotective
[+]
Berberine alleviates paclitaxel-induced neuropathy.
May 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Pharmacopuncture. 2019 Jun ;22(2):90-94. Epub 2019 Jun 30. PMID:
31338248
Article Published Date
: May 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Chemotherapy-Induced Toxicity: Paclitaxel
Pharmacological Actions
:
Chemoprotective Agents
[+]
Berberine alleviates programmed necrosis of metabolic-associated fatty liver disease.
Feb 19, 2022
Click here to read the entire abstract
Pubmed Data
: Zhonghua Gan Zang Bing Za Zhi. 2022 Feb 20 ;30(2):224-229. PMID:
35359076
Article Published Date
: Feb 19, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
,
Nrf2 activation
[+]
Berberine alleviates symptoms of anxiety by enhancing dopamine expression in rats with post-traumatic stress disorder.
Feb 28, 2018
Click here to read the entire abstract
Pubmed Data
: Korean J Physiol Pharmacol. 2018 Mar ;22(2):183-192. Epub 2018 Feb 23. PMID:
29520171
Article Published Date
: Feb 28, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Post-Traumatic Stress Disorders (PTSD)
Pharmacological Actions
:
Anti-Anxiety Agents
Additional Keywords
:
Anti-Anxiety Agents
,
Berberine
,
Post-Traumatic Stress Disorders (PTSD)
[+]
Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression.
Nov 25, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Aging Cell. 2019 Nov 26:e13060. Epub 2019 Nov 26. PMID:
31773901
Article Published Date
: Nov 25, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Aging
Pharmacological Actions
:
Cytoprotective
[+]
Berberine ameliorates cognitive disorder.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Nutr Sci Vitaminol (Tokyo). 2022 ;68(3):228-235. PMID:
35768254
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine ameliorates collagen-induced arthritis in rats by facilitating the generation of butyrate and adjusting the intestinal hypoxia and nitrate supply.
Aug 18, 2019
Click here to read the entire abstract
Pubmed Data
: FASEB J. 2019 Aug 19:fj201900425RR. Epub 2019 Aug 19. PMID:
31425655
Article Published Date
: Aug 18, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Arthritis
Pharmacological Actions
:
Gastrointestinal Agents
[+]
Berberine ameliorates colonic damage accompanied with the modulation of dysfunctional bacteria and functions in ulcerative colitis rats.
Jan 31, 2020
Click here to read the entire abstract
Pubmed Data
: Appl Microbiol Biotechnol. 2020 Feb ;104(4):1737-1749. Epub 2019 Dec 23. PMID:
31867696
Article Published Date
: Jan 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Gastroprotective
[+]
Berberine ameliorates depression-like behavior.
Sep 10, 2022
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2022 Sep 11. Epub 2022 Sep 11. PMID:
36089660
Article Published Date
: Sep 10, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Depression
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antidepressive Agents
,
Interleukin-10 upregulation
,
Interleukin-1 beta downregulation
,
Interleukin-4 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine ameliorates dextran sulfate sodium-induced ulcerative colitis.
Jul 22, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Metabolites. 2022 Jul 23 ;12(8). Epub 2022 Jul 23. PMID:
35893243
Article Published Date
: Jul 22, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Gastrointestinal Agents
[+]
Berberine ameliorates diabetic nephropathy.
Mar 30, 2018
Click here to read the entire abstract
Pubmed Data
: Biol Res. 2018 Mar 31 ;51(1):9. Epub 2018 Mar 31. PMID:
29604956
Article Published Date
: Mar 30, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
[+]
Berberine ameliorates diabetic neuropathy.
Nov 08, 2017
Click here to read the entire abstract
Pubmed Data
: Am J Chin Med. 2017 Nov 9:1-15. Epub 2017 Nov 9. PMID:
29121795
Article Published Date
: Nov 08, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Neuropathies
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Berberine
,
Berberine ameliorates diabetic neuropathy
,
berberine substance
,
gmi berberine
,
gmi berberine substance
,
GreenMedInfo Berberine
,
GreenMedInfo Berberine ameliorates diabetic neuropathy
[+]
Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus.
Oct 20, 2021
Click here to read the entire abstract
Pubmed Data
: Andrology. 2021 Oct 21. Epub 2021 Oct 21. PMID:
34674380
Article Published Date
: Oct 20, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Complications
,
Erectile Dysfunction
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Fibrotic
[+]
Berberine ameliorates experimental varicocele-induced damages at testis and sperm levels.
Oct 16, 2018
Click here to read the entire abstract
Pubmed Data
: Andrologia. 2018 Oct 17:e13179. Epub 2018 Oct 17. PMID:
30334274
Article Published Date
: Oct 16, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Varicocele
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine ameliorates hepatic insulin resistance by regulating microRNA-146b/SIRT1 pathway.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Diabetes Metab Syndr Obes. 2021 ;14:2525-2537. Epub 2021 Jun 4. PMID:
34113144
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Hepatoprotective
,
MicroRNA modulator
[+]
Berberine ameliorates high-fat diet-induced non-alcoholic fatty liver disease.
Jan 31, 2019
Click here to read the entire abstract
Pubmed Data
: Curr Med Sci. 2019 Feb ;39(1):37-43. Epub 2019 Mar 13. PMID:
30868489
Article Published Date
: Jan 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
[+]
Berberine ameliorates insulin resistance.
Jul 20, 2022
Click here to read the entire abstract
Pubmed Data
: Metab Syndr Relat Disord. 2022 Jul 21. Epub 2022 Jul 21. PMID:
35862014
Article Published Date
: Jul 20, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Gestational Diabetes
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process.
Jan 02, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Jan 3 ;87:200-208. Epub 2017 Jan 3. PMID:
28061403
Article Published Date
: Jan 02, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Brain Inflammation
,
Epilepsy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
Berberine ameliorates MCAO induced cerebral ischemia-reperfusion injury.
Jan 21, 2018
Click here to read the entire abstract
Pubmed Data
: Neurochem Res. 2018 Jan 22. Epub 2018 Jan 22. PMID:
29357017
Article Published Date
: Jan 21, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Brain-derived neurotrophic factor modulator
,
Neuroprotective Agents
[+]
Berberine ameliorates mesenteric vascular dysfunction by modulating perivascular adipose tissue in diet-induced obese in rats.
Jul 24, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Med Ther. 2022 Jul 25 ;22(1):198. Epub 2022 Jul 25. PMID:
35879716
Article Published Date
: Jul 24, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hypoglycemic Agents
,
Hypolipidemic
[+]
Berberine ameliorates myocardial ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis.
Jan 24, 2016
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2016 Jan 25. Epub 2016 Jan 25. PMID:
26806299
Article Published Date
: Jan 24, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Berberine ameliorates neuronal AD-like change via activating Pi3k/PGCε pathway.
Mar 18, 2021
Click here to read the entire abstract
Pubmed Data
: Biofactors. 2021 Mar 19. Epub 2021 Mar 19. PMID:
33740285
Article Published Date
: Mar 18, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine ameliorates non alcoholic fatty liver disease and related metabolic disorders.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(8):e0134172. Epub 2015 Aug 7. PMID:
26252777
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Metabolic Diseases
,
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Gene Expression Regulation
[+]
Berberine ameliorates nonalcoholic fatty liver disease by decreasing the liver lipid content.
Sep 30, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2021 Oct ;22(4):1109. Epub 2021 Aug 3. PMID:
34504563
Article Published Date
: Sep 30, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
,
Hypolipidemic
[+]
Berberine ameliorates NSAIDs-induced intestinal injury by the repair of enteric nervous system.
Sep 12, 2019
Click here to read the entire abstract
Pubmed Data
: Fundam Clin Pharmacol. 2019 Sep 13. Epub 2019 Sep 13. PMID:
31520444
Article Published Date
: Sep 12, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Drug-Induced Toxicity: Gastrointestinal
Pharmacological Actions
:
Gastroprotective
Problem Substances
:
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]
Berberine ameliorates obesity-induced chronic inflammation.
Jul 06, 2020
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2020 Jul 7 ;86:106741. Epub 2020 Jul 7. PMID:
32650294
Article Published Date
: Jul 06, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Inflammation
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Berberine ameliorates periodontal bone loss by regulating gut microbiota.
Sep 09, 2018
Click here to read the entire abstract
Pubmed Data
: J Dent Res. 2018 Sep 10:22034518797275. Epub 2018 Sep 10. PMID:
30199654
Article Published Date
: Sep 09, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Osteoporosis
,
Periodontitis
,
Postmenopausal Disorders
Pharmacological Actions
:
Gastrointestinal Agents
,
Osteoprotective
[+]
Berberine ameliorates prenatal dihydrotestosterone exposure-induced autism-like behaviour by suppression of androgen receptor.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Cell Neurosci. 2020 ;14:87. Epub 2020 Apr 9. PMID:
32327976
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Autism
,
Fetal Origin of Adult Disease
,
Polycystic Ovary Syndrome
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Risk Reduction
[+]
Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation.
Sep 15, 2022
Click here to read the entire abstract
Pubmed Data
: Drug Dev Res. 2022 Sep 16. Epub 2022 Sep 16. PMID:
36112730
Article Published Date
: Sep 15, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Influenza
,
Lung Inflammation
,
Pneumonia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-18 down-regulation
,
Interleukin-1 beta downregulation
[+]
Berberine ameliorates rats model of combined Alzheimer's disease and type 2 diabetes mellitus via the suppression of endoplasmic reticulum stress.
Jul 31, 2020
Click here to read the entire abstract
Pubmed Data
: 3 Biotech. 2020 Aug ;10(8):359. Epub 2020 Jul 29. PMID:
32832321
Article Published Date
: Jul 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
,
Diabetes: Cognitive Dysfunction
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine ameliorates testosterone-induced benign prostate hyperplasia in rats.
Dec 19, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Med Ther. 2021 Dec 20 ;21(1):301. Epub 2021 Dec 20. PMID:
34930229
Article Published Date
: Dec 19, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Prostatic Hyperplasia: Benign
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
Berberine and cinnamaldehyde together prevent lung carcinogenesis.
Sep 28, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2017 Sep 29 ;8(44):76385-76397. Epub 2017 Aug 7. PMID:
29100319
Article Published Date
: Sep 28, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Cinnamaldehyde
Diseases
:
Lung Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
[+]
Berberine and coptis chinesis (goldenthread) extract prevents neurodegeneration induced by aluminum overload in rats.
Jun 01, 2009
Click here to read the entire abstract
Pubmed Data
: Saudi Med J. 2009 Jun;30(6):760-6. PMID:
19526156
Article Published Date
: Jun 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Goldenthread
Diseases
:
Aluminum Toxicity
[+]
Berberine and evodiamine regulate the expression of important genes that could be beneficial in colon cancer treatments.
Feb 28, 2017
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2017 Mar ;37(3):1637-1645. Epub 2017 Jan 17. PMID:
28098901
Article Published Date
: Feb 28, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
,
Evodiamine
Diseases
:
Colon Cancer
Pharmacological Actions
:
Chemopreventive
,
Chemotherapeutic
,
MicroRNA modulator
[+]
Berberine and ginsenoside Rb1 ameliorate depression-like behavior.
May 26, 2021
Click here to read the entire abstract
Pubmed Data
: Am J Chin Med. 2021 May 27:1-19. Epub 2021 May 27. PMID:
34049474
Article Published Date
: May 26, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Ginsenosides
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
[+]
Berberine as a promising natural compound for the treatment of periodontal disease.
Oct 29, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cell Mol Med. 2021 Oct 30. Epub 2021 Oct 30. PMID:
34719112
Article Published Date
: Oct 29, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Periodontal Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-17 downregulation
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine atenuates neonatal sepsis in mice
Sep 13, 2021
Click here to read the entire abstract
Pubmed Data
: Inflammation. 2021 Sep 14. Epub 2021 Sep 14. PMID:
34523052
Article Published Date
: Sep 13, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Sepsis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine attenuate staphylococcal enterotoxin B-mediated acute liver injury via regulating HDAC expression.
Sep 30, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: AMB Express. 2018 Oct 1 ;8(1):158. Epub 2018 Oct 1. PMID:
30276552
Article Published Date
: Sep 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Staphylococcal Infections
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
[+]
Berberine attenuates 1,2-dimethylhydrazine dihydrochloride-(DMH-) induced cororectal cancer.
Jun 29, 2021
Click here to read the entire abstract
Pubmed Data
: Ann Hepatobiliary Pancreat Surg. 2021 Jun 30 ;25(Suppl 1):S399. PMID:
34230296
Article Published Date
: Jun 29, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
[+]
Berberine attenuates arterial plaque formation.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Des Devel Ther. 2020 ;14:2449-2460. Epub 2020 Jun 23. PMID:
32606611
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Berberine attenuates arthritis in adjuvant-induced arthritis.
Feb 19, 2019
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2019 Feb 20. Epub 2019 Feb 20. PMID:
30796904
Article Published Date
: Feb 19, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-17 downregulation
,
NF-kappaB Inhibitor
[+]
Berberine attenuates atherosclerotic lesions and hepatic steatosis.
Sep 30, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Ann Transl Med. 2021 Oct ;9(20):1517. PMID:
34790723
Article Published Date
: Sep 30, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Atherosclerosis
,
Hepatic Steatosis
Pharmacological Actions
:
Hepatoprotective
,
Hypolipidemic
[+]
Berberine attenuates cerebral ischemia-reperfusion injury induced neuronal apoptosis.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2021 ;12:609693. Epub 2021 Apr 28. PMID:
33995012
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Berberine attenuates diabetic atherosclerosis.
Jan 07, 2022
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2022 10 8 ;624:59-67. Epub 2022 Jul 31. PMID:
35933927
Article Published Date
: Jan 07, 2022
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Atherosclerosis
,
Inflammation
Pharmacological Actions
:
Hypoglycemic Agents
,
Hypolipidemic
[+]
Berberine attenuates experimental autoimmune encephalomyelitis in mice.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: PLoS One. 2010;5(10):e13489. Epub 2010 Oct 19. PMID:
20976070
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Blood-Brain-Barrier Disorders
,
Brain Inflammation
,
Multiple Sclerosis
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Berberine attenuates hepatic oxidative stress in rats with non-alcoholic fatty liver disease.
Feb 28, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2019 Mar ;17(3):2091-2098. Epub 2019 Jan 28. PMID:
30867696
Article Published Date
: Feb 28, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
,
Nrf2 activation
[+]
Berberine attenuates hepatic steatosis and enhances energy expenditure.
Oct 23, 2017
Click here to read the entire abstract
Pubmed Data
: Br J Pharmacol. 2017 Oct 24. Epub 2017 Oct 24. PMID:
29065221
Article Published Date
: Oct 23, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Fatty Liver
,
Liver Steatosis
,
Obesity
Pharmacological Actions
:
Autophagy Up-regulation
,
Fibroblast growth factor 21 upregulation
,
Hepatoprotective
[+]
Berberine attenuates hyperglycemia by inhibiting the hepatic glucagon pathway in diabetic mice
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2020 ;2020:6210526. Epub 2020 Jan 3. PMID:
31976031
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hyperglycemia
Pharmacological Actions
:
Antihypertensive Agents
[+]
Berberine attenuates hypoxia-induced pulmonary arterial hypertension.
Feb 19, 2019
Click here to read the entire abstract
Pubmed Data
: J Cell Physiol. 2019 Feb 20. Epub 2019 Feb 20. PMID:
30786011
Article Published Date
: Feb 19, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hypertension
,
Hypoxia
Pharmacological Actions
:
Antihypertensive Agents
[+]
Berberine attenuates intestinal tumorigenesis by inhibiting the migration and invasion of colorectal tumor cells.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2016 ;2016:5137505. Epub 2016 Jul 17. PMID:
27493671
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Colon Cancer: Prevention
,
Gastric Polyposis
,
Intestinal Polyps
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
[+]
Berberine attenuates ischemia-reperfusion injury.
Sep 27, 2018
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2018 Sep 28. Epub 2018 Sep 28. PMID:
30266998
Article Published Date
: Sep 27, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine attenuates macrophages infiltration in intracranial aneurysms.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2018 ;9:565. Epub 2018 May 30. PMID:
29899701
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Aneurysm: Cerebral
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway.
Jun 17, 2019
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2019 Jun 18 ;141:192-204. Epub 2019 Jun 18. PMID:
31226399
Article Published Date
: Jun 17, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
[+]
Berberine attenuates olanzapine induced-metabolic syndrome.
Jul 31, 2019
Click here to read the entire abstract
Pubmed Data
: J Pak Med Assoc. 2019 Aug ;69(Suppl 3)(8):S88-S92. PMID:
31603885
Article Published Date
: Jul 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Metabolic Diseases
Pharmacological Actions
:
Hypolipidemic
Problem Substances
:
Olanzapine
[+]
Berberine attenuates pulmonary arterial hypertension.
Aug 04, 2018
Click here to read the entire abstract
Pubmed Data
: J Cell Physiol. 2018 Aug 5. Epub 2018 Aug 5. PMID:
30078229
Article Published Date
: Aug 04, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Hypertension: Pulmonary
Pharmacological Actions
:
Antihypertensive Agents
[+]
Berberine attenuates sepsis-induced cardiac dysfunction by upregulating the Akt/eNOS pathway in mice.
May 31, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2022 Jun ;23(6):371. Epub 2022 Apr 5. PMID:
35495613
Article Published Date
: May 31, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Sepsis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cardioprotective
[+]
Berberine attenuates severity of chronic pancreatitis and fibrosis.
Jul 24, 2020
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2020 Jul 25 ;403:115162. Epub 2020 Jul 25. PMID:
32721432
Article Published Date
: Jul 24, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Fibrosis
,
Pancreatitis
Pharmacological Actions
:
Pancreato Protective Agents
,
Transforming growth factor beta (TGF-β) inhibitor
[+]
Berberine can ameliorate pro-inflammatory cytokines induced intestinal permeability in vitro,
Feb 08, 2010
Click here to read the entire abstract
Pubmed Data
: Eur J Pharm Sci. 2010 Feb 8. Epub 2010 Feb 8. PMID:
20149867
Article Published Date
: Feb 08, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Intestinal Permeability
[+]
Berberine can ameliorate tubulointerstitial fibrosis in diabetic nephropathy.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2016 ;17(8). Epub 2016 Aug 12. PMID:
27529235
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 1
,
Diabetic Nephropathy
,
Kidney Fibrosis
Pharmacological Actions
:
Anti-Fibrotic
,
Heme oxygenase-1 up-regulation
,
Nrf2 activation
,
Renoprotective
[+]
Berberine can be a potential therapeutic agent for osteoclast-related bone diseases.
Mar 03, 2019
Click here to read the entire abstract
Pubmed Data
: Am J Chin Med. 2019 Mar 4:1-17. Epub 2019 Mar 4. PMID:
30827151
Article Published Date
: Mar 03, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Bone Diseases
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Osteoprotective
[+]
Berberine can be used as a regulator of the intestinal microbiome similar to the probiotics.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Microbiol. 2022 ;13:869931. Epub 2022 Apr 28. PMID:
35572672
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Probiotics
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Gastrointestinal Agents
[+]
Berberine can effectively improve renal function in rats with renal ischemia-reperfusion injury.
Aug 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Sep ;16(3):2008-2012. Epub 2018 Jul 4. PMID:
30186432
Article Published Date
: Aug 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Ischemia
Pharmacological Actions
:
Renoprotective
[+]
Berberine can improve insulin resistance of skeletal muscle in rats.
Oct 31, 2015
Click here to read the entire abstract
Pubmed Data
: Sichuan Da Xue Xue Bao Yi Xue Ban. 2015 Nov ;46(6):827-31. PMID:
26867315
Article Published Date
: Oct 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Berberine can improve myocardial injury and cardiac function in sepsis.
Sep 21, 2020
Click here to read the entire abstract
Pubmed Data
: Zhonghua Yi Xue Za Zhi. 2020 Sep 22 ;100(35):2779-2784. PMID:
32972060
Article Published Date
: Sep 21, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cardiomyopathy
,
Lipopolysaccharide-Induced Toxicity
,
Sepsis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine can prevent fructose-induced insulin resistance in rats
Oct 01, 2006
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2006 Oct 1;216(1):11-9. Epub 2006 May 17. PMID:
18563319
Article Published Date
: Oct 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Fructose-Induced Toxicity
,
Insulin Resistance
,
Liver Stress: Fructose-Induced
[+]
Berberine can promote angiogenesis in the rat with cerebral ischemia-reperfusion injury.
Sep 30, 2018
Click here to read the entire abstract
Pubmed Data
: J Coll Physicians Surg Pak. 2018 Oct ;28(10):753-757. PMID:
30266118
Article Published Date
: Sep 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Angiogenesis Inducing Agents
[+]
Berberine can reduce the acquisition and reinstatement of morphine-induced conditioned place preference.
Feb 29, 2016
Click here to read the entire abstract
Pubmed Data
: Avicenna J Phytomed. 2016 Mar-Apr;6(2):198-204. PMID:
27222833
Article Published Date
: Feb 29, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Morphine Tolerance/Dependence
[+]
Berberine can reverse chronic inflammatory pain induced by complete freund's adjuvant and alleviated the comorbid depression.
Apr 09, 2018
Click here to read the entire abstract
Pubmed Data
: Zhonghua Yi Xue Za Zhi. 2018 Apr 10 ;98(14):1103-1108. PMID:
29690724
Article Published Date
: Apr 09, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Depression
,
Hyperalgesia
,
Inflammation
Pharmacological Actions
:
Analgesics
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine can suppress the proliferation of liver cancer cells by reducing SLC1A5 expression.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Onco Targets Ther. 2019 ;12:11751-11763. Epub 2019 Dec 31. PMID:
32021249
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
[+]
Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of Streptozotocin induced diabetic rats.
Aug 22, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Aug 23 ;95:175-185. Epub 2017 Aug 23. PMID:
28843149
Article Published Date
: Aug 22, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Hypoglycemic Agents
,
NF-kappaB Inhibitor
,
Pancreato Protective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Diabetes Mellitus: Type 1
[+]
Berberine chloride may be considered as a potential treatment for cognitive deficits and neuronal injury.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran J Basic Med Sci. 2018 Jan ;21(1):53-58. PMID:
29372037
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Dementia
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine chloride suppresses non-small cell lung cancer.
Jun 30, 2020
Click here to read the entire abstract
Pubmed Data
: Cancer Chemother Pharmacol. 2020 Jul ;86(1):151-161. Epub 2020 Jun 30. PMID:
32607786
Article Published Date
: Jun 30, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Carcinoma: Non-Small-Cell Lung
Pharmacological Actions
:
Antiproliferative
[+]
Berberine clears Aβ deposit and consequently ameliorates spatial learning memory impairment.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2019 ;10:1003. Epub 2019 Sep 6. PMID:
31551793
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
,
Diabetes: Cognitive Dysfunction
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
Berberine combined with cyclosporine A alleviates acute graft-versus-host disease in murine models.
Feb 08, 2020
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2020 Feb 9 ;81:106205. Epub 2020 Feb 9. PMID:
32050154
Article Published Date
: Feb 08, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Graft vs Host Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
NF-kappaB Inhibitor
[+]
Berberine combined with HMQ1611 exhibited potential antitumor activities against human liver cancer in vitro and in vivo.
Dec 17, 2018
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2018 Dec 18. Epub 2018 Dec 18. PMID:
30565332
Article Published Date
: Dec 17, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Wnt/β-catenin signaling pathway modulation
[+]
Berberine confers neuroprotection in coping with focal cerebral ischemia.
May 07, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Chem Neuroanat. 2017 May 8. Epub 2017 May 8. PMID:
28495517
Article Published Date
: May 07, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
Berberine could alleviate postoperative cognitive dysfunction by suppressing neuroinflammation in aged mice.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2016 Jul 1 ;38:426-433. Epub 2016 Jul 1. PMID:
27376853
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Brain Inflammation
,
Cognitive Decline/Dysfunction
,
Postoperative Recovery
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine could ameliorate cardiac dysfunction in a model of diabetic cardiomyopathy.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Physiol. 2018 ;9:1042. Epub 2018 Aug 2. PMID:
30131709
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cardiomyopathy
,
Diabetic Complications
Pharmacological Actions
:
Cardioprotective
[+]
Berberine could ameliorate the renal impairment and inhibit the podocyte dysfunction in diabetic rat.
Jul 22, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Diabetes Investig. 2019 Jul 23. Epub 2019 Jul 23. PMID:
31336024
Article Published Date
: Jul 22, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Renoprotective
[+]
Berberine could attenuate liver damage induced by a high fat mainly via the protection for mitochondria.
Aug 05, 2016
Click here to read the entire abstract
Pubmed Data
: Fish Physiol Biochem. 2016 Aug 6. Epub 2016 Aug 6. PMID:
27497985
Article Published Date
: Aug 05, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
High Fat Diet
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
[+]
Berberine could be a promising anti-diabetic nephropathy medicine in the future.
Apr 20, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cell Mol Med. 2016 Apr 21. Epub 2016 Apr 21. PMID:
27098986
Article Published Date
: Apr 20, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Complications
,
Diabetic Nephropathy
Pharmacological Actions
:
Renoprotective
[+]
Berberine could be used in the treatment or prevention of obesity-associated NAFLD.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 ;6:22612. Epub 2016 Mar 3. PMID:
26936230
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hepatic Steatosis
,
Inflammation
,
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Berberine could effectively alleviate motor dysfunction and prolong the survival of transgenic N171-82Q HD mice.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(7):e0134142. Epub 2015 Jul 30. PMID:
26225560
Article Published Date
: Dec 31, 2014
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Huntington Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine could generate an anti-osteosarcoma property through downregulating caspase-1/IL-1β inflammatory signaling axis.
Jan 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Rep. 2017 Feb ;37(2):729-736. Epub 2016 Dec 16. PMID:
28000894
Article Published Date
: Jan 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Antiproliferative
,
Interleukin-1 beta downregulation
[+]
Berberine could significantly improve the spatial learning and memory abilities of rats with vascular cognitive impairment.
Jul 27, 2019
Click here to read the entire abstract
Pubmed Data
: Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2019 Jul 28 ;35(4):359-362. PMID:
31701723
Article Published Date
: Jul 27, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Brain: Oxidative Stress
,
Brain Inflammation
,
Cognitive Decline/Dysfunction
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine decreased serum levels of glycosylated hemoglobin, total cholesterol and triglyceride and increase the secretion of insulin.
Feb 15, 2016
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2016 Feb 16. Epub 2016 Feb 16. PMID:
26888689
Article Published Date
: Feb 15, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
[+]
Berberine decreases insulin resistance in a polycystic ovarian syndrome model.
Nov 24, 2019
Click here to read the entire abstract
Pubmed Data
: Regul Toxicol Pharmacol. 2019 Nov 25:104544. Epub 2019 Nov 25. PMID:
31778716
Article Published Date
: Nov 24, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Insulin Resistance
,
Polycystic Ovary Syndrome
Pharmacological Actions
:
Insulin Sensitizers
[+]
Berberine decreases intestinal GLUT2 translocation and reduces intestinal glucose absorption.
Dec 27, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2021 Dec 28 ;23(1). Epub 2021 Dec 28. PMID:
35008753
Article Published Date
: Dec 27, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Hypoglycemic Agents
[+]
Berberine decreases the expression of EBNA1 and exhibits an antitumor effects against nasopharyngeal carcinoma.
Mar 31, 2017
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2017 Apr ;37(4):2109-2120. Epub 2017 Mar 2. PMID:
28259949
Article Published Date
: Mar 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Nasopharyngeal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5.
Nov 30, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Acta Pharm Sin B. 2020 Dec ;10(12):2299-2312. Epub 2020 Jun 30. PMID:
33354502
Article Published Date
: Nov 30, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cancers: All
Pharmacological Actions
:
Immunomodulatory
[+]
Berberine down-regulated myostatin rxpression and facilitated metabolism via smad pathway in insulin resistance.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Diabetes Metab Syndr Obes. 2020 ;13:4561-4569. Epub 2020 Nov 23. PMID:
33262628
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Berberine enhances gemcitabine‑induced cytotoxicity in bladder cancer.
Jan 31, 2022
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2022 Feb ;47(2). Epub 2021 Dec 22. PMID:
34935059
Article Published Date
: Jan 31, 2022
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Antiproliferative
Additional Keywords
:
Chemotherapeutic Synergy: Gemcitabine
[+]
Berberine enhances L1 expression and axonal remyelination in rats after brachial plexus root avulsion.
Aug 06, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Brain Behav. 2020 Aug 7:e01792. Epub 2020 Aug 7. PMID:
32770668
Article Published Date
: Aug 06, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nerve Injuries
Pharmacological Actions
:
Regenerative
Additional Keywords
:
Nerve Regeneration
[+]
Berberine exerted a protective effect on gut-vascular barrier function in sepsis.
Sep 10, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2018 Sep 11 ;49(4):1342-1351. Epub 2018 Sep 11. PMID:
30205381
Article Published Date
: Sep 10, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Sepsis
Pharmacological Actions
:
Gastroprotective
[+]
Berberine exerted a superior anti-arthritic effect and the mechanism maybe involve the balance between Treg and Th17 cells.
Mar 05, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Mar 6 ;89:887-893. Epub 2017 Mar 6. PMID:
28282791
Article Published Date
: Mar 05, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-10 upregulation
,
Interleukin-17 downregulation
,
Interleukin-6 Downregulation
[+]
Berberine exerted anticancer effects on human gastric cancer both in vitro and in vivo.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2020 ;2020:6195050. Epub 2020 Apr 8. PMID:
32328135
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
[+]
Berberine exerted protective effects on lead-induced oxidative stress and hepatotoxicity in rats.
Feb 11, 2016
Click here to read the entire abstract
Pubmed Data
: Redox Rep. 2016 Feb 12. Epub 2016 Feb 12. PMID:
26871196
Article Published Date
: Feb 11, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Lead Poisoning
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
[+]
Berberine exerts a protective action against carbon tetrachloride induced acute liver injury.
Aug 05, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2019 Aug 6. Epub 2019 Aug 6. PMID:
31432116
Article Published Date
: Aug 05, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Hepatoprotective
[+]
Berberine exerts a protective effect on rats with polycystic ovary syndrome.
Jan 06, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Reprod Biol Endocrinol. 2021 Jan 7 ;19(1):3. Epub 2021 Jan 7. PMID:
33407557
Article Published Date
: Jan 06, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Polycystic Ovary Syndrome
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine exerts neuroprotective activities against cerebral ischemia/reperfusion injury.
Sep 10, 2021
Click here to read the entire abstract
Pubmed Data
: Brain Res Bull. 2021 Sep 11 ;177:22-30. Epub 2021 Sep 11. PMID:
34517069
Article Published Date
: Sep 10, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine exerts protective effects on cardiac senescence by regulating the Klotho/SIRT1 signaling pathway.
Jun 30, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Pharmacother. 2022 Jul ;151:113097. Epub 2022 May 24. PMID:
35609366
Article Published Date
: Jun 30, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Cardioprotective
,
SIRT1 Activator
[+]
Berberine exhibited protective effects against doxorubicin induced heart tissue free radical injury.
Mar 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2018 Apr ;15(4):5721-5729. Epub 2018 Feb 9. PMID:
29552206
Article Published Date
: Mar 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Cardioprotective
,
Chemoprotective Agents
[+]
Berberine exhibited renoprotective effects in diabetic nephropathy.
Jan 09, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Cell Endocrinol. 2017 Jan 10. Epub 2017 Jan 10. PMID:
28087385
Article Published Date
: Jan 09, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Advanced Glycation End products (AGE)
,
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Glycation Agents
,
Renoprotective
[+]
Berberine exhibits neuroprotective qualities against ischemic brain damage in stroke models
Dec 05, 2008
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2008 Dec 5 ;447(1):31-6. Epub 2008 Sep 30. PMID:
18838103
Article Published Date
: Dec 05, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Brain Ischemia
,
Hypoxia
,
Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Ischemia Reperfusion Injury
[+]
Berberine exhibits notable preventive effects on acetaminophen induced hepatotoxicity.
Jun 30, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Jul ;103:1319-1326. Epub 2018 May 7. PMID:
29864914
Article Published Date
: Jun 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Chemically-Induced Liver Damage
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
,
Nrf2 activation
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Berberine facilitates angiogenesis against ischemic stroke.
Apr 23, 2019
Click here to read the entire abstract
Pubmed Data
: Cell Mol Neurobiol. 2019 Apr 24. Epub 2019 Apr 24. PMID:
31020571
Article Published Date
: Apr 23, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Stroke: Ischemic
Pharmacological Actions
:
Angiogenesis Inducing Agents
[+]
Berberine functions as a negative regulator in lipopolysaccharide -induced sepsis.
Oct 06, 2020
Click here to read the entire abstract
Pubmed Data
: Pathog Dis. 2020 Oct 7 ;78(7). PMID:
32857851
Article Published Date
: Oct 06, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Lipopolysaccharide-Induced Toxicity
,
Sepsis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine had suppressive effects on atherosclerosis.
Jan 29, 2018
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2018 Jan 30. Epub 2018 Jan 30. PMID:
29393413
Article Published Date
: Jan 29, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Anti-atherogenic
,
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine has a beneficial effect against diabetic neuropathy by improving micropathology and increasing neuritin expression.
Feb 02, 2016
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2016 Feb 3. Epub 2016 Feb 3. PMID:
26849937
Article Published Date
: Feb 02, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Neuropathy
Pharmacological Actions
:
MicroRNA modulator
,
Neuroprotective Agents
[+]
Berberine has a preventive effect on experimental colon cancer.
Oct 01, 2010
Click here to read the entire abstract
Pubmed Data
: Zhongguo Zhong Yao Za Zhi. 2010 Oct;35(20):2768-73. PMID:
21246838
Article Published Date
: Oct 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Colon Cancer
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
[+]
Berberine has a substantial effect in improving metabolic parameters and modulating the gut microbiota composition in T2DM.
Feb 27, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: World J Gastroenterol. 2021 Feb 28 ;27(8):708-724. PMID:
33716449
Article Published Date
: Feb 27, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Gastrointestinal Agents
,
Hypoglycemic Agents
[+]
Berberine has an anti-tumor effect on colitis-associated colorectal cancer.
Jul 30, 2017
Click here to read the entire abstract
Pubmed Data
: Lab Invest. 2017 Jul 31. Epub 2017 Jul 31. PMID:
28759012
Article Published Date
: Jul 30, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Colitis
,
Colon Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
[+]
Berberine has anti-inflammatory effects on H. pylori-induced chronic gastritis.
Jan 17, 2018
Click here to read the entire abstract
Pubmed Data
: J Cell Biochem. 2018 Jan 18. Epub 2018 Jan 18. PMID:
29345340
Article Published Date
: Jan 17, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Helicobacter Pylori Infection
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Immunomodulatory: Th17 downregulation
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
[+]
Berberine has anticonvulsant activity in mice.
Jul 01, 2010
Click here to read the entire abstract
Pubmed Data
: Epilepsy Behav. 2010 Jul;18(3):207-10. PMID:
20638957
Article Published Date
: Jul 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Convulsions
,
Seizures
Pharmacological Actions
:
Anticonvulsants
[+]
Berberine has protective effect for diabetes through increasing insulin expression, beta cell regeneration, antioxidant enzyme activity and decreasing lipid peroxidation.
Mar 15, 2009
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2009 Mar 15;606(1-3):262-8. Epub 2009 Jan 19. PMID:
19374872
Article Published Date
: Mar 15, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 1
Additional Keywords
:
Beta Cell Regeneration
[+]
Berberine has protective effects against macrovascular complications induced by diabetes mellitus.
Sep 03, 2020
Click here to read the entire abstract
Pubmed Data
: Endocr Metab Immune Disord Drug Targets. 2020 Sep 4. Epub 2020 Sep 4. PMID:
32888284
Article Published Date
: Sep 03, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cytoprotective
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Transforming growth factor beta (TGF-β) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine hydrochloride attenuates liver injury induced by acute hypoxic exposure.
Dec 31, 2021
Click here to read the entire abstract
Pubmed Data
: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2022 Jan ;38(1):48-53. PMID:
35078575
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine hydrochloride can provide mice robust protection from LPS-induced mastitis.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2018 ;2018:5164314. Epub 2018 Apr 15. PMID:
29849710
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Lipopolysaccharide-Induced Toxicity
,
Mastitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine impairs coxsackievirus B3-induced myocarditis through the inhibition of virus replication and host pro-inflammatory response.
Dec 17, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Med Virol. 2020 Dec 18. Epub 2020 Dec 18. PMID:
33336842
Article Published Date
: Dec 17, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Coxsackievirus Infections
,
Myocarditis: Viral
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
[+]
Berberine improved metabolic function in a mouse model fed a high-fat diet.
Jan 03, 2019
Click here to read the entire abstract
Pubmed Data
: Med Sci Monit. 2019 Jan 4 ;25:87-97. Epub 2019 Jan 4. PMID:
30606998
Article Published Date
: Jan 03, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
High Fat Diet
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Berberine Improves behavioral and cognitive deficits in a mouse model of Alzheimer's disease.
May 12, 2021
Click here to read the entire abstract
Pubmed Data
: ACS Chem Neurosci. 2021 May 13. Epub 2021 May 13. PMID:
33983710
Article Published Date
: May 12, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine improves benign prostatic hyperplasia.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Front Pharmacol. 2018 ;9:773. Epub 2018 Jul 16. PMID:
30061836
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Prostatic Hyperplasia: Benign
[+]
Berberine improves cognitive impairment by simultaneously impacting cerebral blood flow and β-amyloid accumulation.
May 10, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cells. 2021 May 11 ;10(5). Epub 2021 May 11. PMID:
34064687
Article Published Date
: May 10, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites.
Dec 03, 2020
Click here to read the entire abstract
Pubmed Data
: Pharmacol Res. 2020 Dec 4:105358. Epub 2020 Dec 4. PMID:
33285228
Article Published Date
: Dec 03, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Colitis
Pharmacological Actions
:
Gastrointestinal Agents
[+]
Berberine improves free-fatty-acid-induced insulin resistance.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: Metabolism. 2009 Dec;58(12):1694-702. Epub 2009 Sep 19. PMID:
19767038
Article Published Date
: Dec 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Hypoglycemic Agents
[+]
Berberine improves inflammatory responses of diabetes mellitus.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Immunol Res. 2020 ;2020:2141508. Epub 2020 Aug 18. PMID:
32908938
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine improves insulin-induced diabetic retinopathy in type I and II diabetes.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Biol Sci. 2021 ;17(15):4316-4326. Epub 2021 Oct 20. PMID:
34803500
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Retinopathy
Pharmacological Actions
:
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Berberine improves intestinal barrier function and reduces inflammation, immunosuppression, and oxidative stress.
Nov 14, 2021
Click here to read the entire abstract
Pubmed Data
: Environ Pollut. 2021 Nov 15 ;289:117865. Epub 2021 Jul 31. PMID:
34358871
Article Published Date
: Nov 14, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Gastroprotective
,
NF-kappaB Inhibitor
[+]
Berberine improves intralipid-induced insulin resistance in murine.
Aug 06, 2020
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2020 Aug 7. Epub 2020 Aug 7. PMID:
32770172
Article Published Date
: Aug 06, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hyperglycemia
,
Insulin Resistance
[+]
Berberine improves irinotecan-induced intestinal mucositis without impairing the anti-colorectal cancer efficacy of irinotecan.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2021 ;12:774560. Epub 2021 Nov 2. PMID:
34795594
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Chemotherapy-Induced Toxicity: Irinotecan
Pharmacological Actions
:
Chemoprotective Agents
,
Gastrointestinal Agents
,
Gastroprotective
[+]
Berberine improves liver injury induced glucose and lipid metabolic disorders.
Dec 29, 2021
Click here to read the entire abstract
Pubmed Data
: Bioorg Med Chem. 2021 Dec 30 ;55:116598. Epub 2021 Dec 30. PMID:
34979291
Article Published Date
: Dec 29, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Liver Damage
Pharmacological Actions
:
Gastrointestinal Agents
,
Hepatoprotective
[+]
Berberine improves the protective effects of metformin on diabetic nephropathy.
Oct 31, 2021
Click here to read the entire abstract
Pubmed Data
: Pharm Res. 2021 Nov ;38(11):1807-1820. Epub 2021 Nov 12. PMID:
34773184
Article Published Date
: Oct 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Berberine Improves the Symptoms of DHEA-Induced PCOS.
Dec 31, 2020
Click here to read the entire abstract
Pubmed Data
: Gynecol Obstet Invest. 2021 ;86(4):388-397. Epub 2021 Aug 18. PMID:
34515131
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Polycystic Ovary Syndrome
Pharmacological Actions
:
Gastrointestinal Agents
[+]
Berberine in combination with yohimbine therapy attenuates neutrophil tissue infiltration and multiple organ injury in septic mice.
Apr 11, 2016
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2016 Apr 12 ;35:217-225. Epub 2016 Apr 12. PMID:
27082997
Article Published Date
: Apr 11, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Sepsis
[+]
Berberine induced senescence of human glioblastoma cells.
Jan 31, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Cancer Ther. 2015 Feb ;14(2):355-63. Epub 2014 Dec 12. PMID:
25504754
Article Published Date
: Jan 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Glioblastoma
Pharmacological Actions
:
Anti-Tumor
,
Apoptotic
,
Cell cycle arrest
,
Epidermal growth factor receptor (EGFR) inhibitor
[+]
Berberine inhibited angiogenesis in glioblastoma xenografts.
Nov 30, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharm Biol. 2018 Dec ;56(1):665-671. PMID:
31070539
Article Published Date
: Nov 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Glioblastoma
Pharmacological Actions
:
Angiogenesis Inhibitors
[+]
Berberine inhibits adipogenesis in high-fat diet-induced obesity mice.
Oct 25, 2009
Click here to read the entire abstract
Pubmed Data
: Fitoterapia. 2009 Oct 25. Epub 2009 Oct 25. PMID:
19861153
Article Published Date
: Oct 25, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Obesity
Pharmacological Actions
:
Anti-Adipogenic
[+]
Berberine inhibits carcinogenesis through antagonizing the ATX-LPA-LPAR2-p38-leptin axis in a mouse hepatoma model.
Sep 14, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Ther Oncolytics. 2022 Sep 15 ;26:372-386. Epub 2022 Aug 5. PMID:
36090480
Article Published Date
: Sep 14, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Liver Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemopreventive
,
Interleukin-1 beta downregulation
,
Interleukin-4 downregulation
[+]
Berberine inhibits cardiac remodeling of heart failure after myocardial infarction.
Aug 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Sep ;16(3):2499-2505. Epub 2018 Jul 11. PMID:
30186485
Article Published Date
: Aug 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Myocardial Infarction
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Berberine inhibits colorectal tumor growth by suppressing SHH secretion.
Sep 20, 2020
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2020 Sep 21. Epub 2020 Sep 21. PMID:
32958873
Article Published Date
: Sep 20, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Tumors
Pharmacological Actions
:
Antiproliferative
[+]
Berberine inhibits dendritic cells differentiation in DSS-induced colitis by promoting Bacteroides fragilis.
Nov 30, 2021
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2021 Dec ;101(Pt A):108329. Epub 2021 Nov 5. PMID:
34749293
Article Published Date
: Nov 30, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Gastrointestinal Agents
,
Interleukin-6 Downregulation
[+]
Berberine inhibits free fatty acid and LPS-induced inflammation via modulating ER stress response in macrophages and hepatocytes.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2020 ;15(5):e0232630. Epub 2020 May 1. PMID:
32357187
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
,
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
[+]
Berberine inhibits human tongue cancer growth in an animal xenograft model.
Mar 19, 2009
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2009 Mar 19. PMID:
19303753
Article Published Date
: Mar 19, 2009
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Tongue Cancer
[+]
Berberine inhibits IFN-γ signaling pathway in DSS-induced ulcerative colitis.
May 31, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Saudi Pharm J. 2022 Jun ;30(6):764-778. Epub 2022 Apr 1. PMID:
35812150
Article Published Date
: May 31, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Gastrointestinal Agents
,
Interferon Gamma Reducer
[+]
Berberine inhibits inflammatory mediators and attenuates acute pancreatitis in animals.
May 01, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Immunol. 2016 May 2 ;74:27-38. Epub 2016 May 2. PMID:
27148818
Article Published Date
: May 01, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Pancreatitis
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Berberine inhibits intestinal carcinogenesis by suppressing intestinal pro-inflammatory genes and oncogenic factors through modulating gut microbiota.
May 19, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Cancer. 2022 May 20 ;22(1):566. Epub 2022 May 20. PMID:
35596224
Article Published Date
: May 19, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Colitis
,
Colorectal Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemopreventive
,
Gastrointestinal Agents
,
NF-kappaB Inhibitor
[+]
Berberine inhibits macrophage M1 polarization to protect against DSS-induced colitis.
Feb 22, 2018
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2018 Feb 23 ;57:121-131. Epub 2018 Feb 23. PMID:
29482156
Article Published Date
: Feb 22, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
[+]
Berberine inhibits the ischemia-reperfusion induced testicular injury through decreasing oxidative stress.
Apr 01, 2019
Click here to read the entire abstract
Pubmed Data
: Am J Emerg Med. 2019 Apr 2. Epub 2019 Apr 2. PMID:
30971358
Article Published Date
: Apr 01, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Ischemia
Pharmacological Actions
:
Antioxidants
[+]
Berberine is a key component in Coptis chinensis with anti-plague activity.
Mar 01, 2009
Click here to read the entire abstract
Pubmed Data
: Planta Med. 2009 Mar;75(4):396-8. Epub 2008 Dec 3. PMID:
19053015
Article Published Date
: Mar 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Coptis chinensis
Diseases
:
Bubonic Plague
Pharmacological Actions
:
Anti-Bacterial Agents
[+]
Berberine is a potential candidate for the treatment of NASH.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2020 ;11:185. Epub 2020 Mar 3. PMID:
32194416
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
[+]
Berberine is a potential drug for the treatment of patients with ischemia-reperfusion injury.
Jan 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Feb ;15(2):1225-1232. Epub 2017 Nov 27. PMID:
29403554
Article Published Date
: Jan 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
,
NF-kappaB Inhibitor
[+]
Berberine is a potential therapeutic alleviating diabetes and diabetic neuropathic pain
May 11, 2019
Click here to read the entire abstract
Pubmed Data
: Naunyn Schmiedebergs Arch Pharmacol. 2019 May 12. Epub 2019 May 12. PMID:
31079200
Article Published Date
: May 11, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Neuropathy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine is a promising therapeutic agent for myocardial ischemia/reperfusion injury.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Cardiovasc Med. 2021 ;8:646306. Epub 2021 May 26. PMID:
34124190
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Myocardial Ischemia
[+]
Berberine markedly ameliorates aging-related reductions in cognitive ability and muscular function.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Nutr Health Aging. 2018 ;22(6):710-717. PMID:
29806860
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Aging: Brain
,
Cognitive Decline/Dysfunction
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine may act as a potential neuroprotective agent.
Oct 12, 2016
Click here to read the entire abstract
Pubmed Data
: Neurotoxicology. 2016 Oct 13 ;57:241-250. Epub 2016 Aug 13. PMID:
27746125
Article Published Date
: Oct 12, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
,
Neurodegenerative Diseases
Pharmacological Actions
:
Anti-Anxiety Agents
,
Neuroprotective Agents
[+]
Berberine may be a candidate therapeutic agent for the treatment of NASH.
Oct 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2017 Nov ;14(5):4134-4140. Epub 2017 Aug 28. PMID:
29075339
Article Published Date
: Oct 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
[+]
Berberine may be a new therapeutic strategy against hepatic steatosis and non-alcoholic steatohepatitis.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 ;6:20848. Epub 2016 Feb 9. PMID:
26857750
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
[+]
Berberine may be a potential therapeutic agent for the treatment of patients with neonatal necrotizing enterocolitis.
Mar 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Apr ;15(4):3530-3536. Epub 2018 Feb 12. PMID:
29545879
Article Published Date
: Mar 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Enterocolitis: Necrotiziing
Pharmacological Actions
:
Anti-Apoptotic
[+]
Berberine may be a potential treatment for controlling bone loss in diabetic osteoporosis.
Sep 13, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Sep 14 ;108:280-287. Epub 2018 Sep 14. PMID:
30223099
Article Published Date
: Sep 13, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Complications
,
Osteoporosis
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Osteoprotective
[+]
Berberine may be a promising treatment for obesity and related metabolic disorders.
Jun 12, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Death Dis. 2019 Jun 13 ;10(6):468. Epub 2019 Jun 13. PMID:
31197160
Article Published Date
: Jun 12, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
Berberine may be an effective therapeutic strategy for the treatment of obesity and insulin resistance.
Apr 30, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2017 May ;15(5):2765-2787. Epub 2017 Mar 14. PMID:
28447763
Article Published Date
: Apr 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Insulin Resistance
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Gastrointestinal Agents
Additional Keywords
:
Microbiota
[+]
Berberine may be protective against retinal diseases involving oxidative stress.
Oct 13, 2015
Click here to read the entire abstract
Pubmed Data
: Exp Eye Res. 2015 Oct 14. Epub 2015 Oct 14. PMID:
26475979
Article Published Date
: Oct 13, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Retinal Diseases
Pharmacological Actions
:
Antioxidants
[+]
Berberine may be used as a novel potential primary prevention means against prehypertension-related atherosclerotic cardiovascular disease.
Oct 18, 2018
Click here to read the entire abstract
Pubmed Data
: Chin J Integr Med. 2018 Oct 19. Epub 2018 Oct 19. PMID:
30341486
Article Published Date
: Oct 18, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Prehypertension
Pharmacological Actions
:
Cardioprotective
[+]
Berberine may exert antitumor effects by suppressing tumor growth and elevating the intestinal mucosal permeability.
Oct 31, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Nov ;107:1447-1453. Epub 2018 Sep 3. PMID:
30257361
Article Published Date
: Oct 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Chemotherapeutic
,
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]
Berberine may have therapeutic value in those with high homocysteine by regulating liver cholesterol synthesis.
Dec 22, 2010
Click here to read the entire abstract
Pubmed Data
: Am J Physiol Regul Integr Comp Physiol. 2010 Dec 22. Epub 2010 Dec 22. PMID:
21178122
Article Published Date
: Dec 22, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
High Cholesterol
,
High Homocysteine
[+]
Berberine mediates tumor cell death by skewing tumor-associated immunosuppressive macrophages to inflammatory macrophages.
Dec 21, 2021
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2021 Dec 22 ;99:153904. Epub 2021 Dec 22. PMID:
35231825
Article Published Date
: Dec 21, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cancers: All
,
Melanoma
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Immunomodulatory
Additional Keywords
:
Tumor Microenvironment
[+]
Berberine might attenuate the liver inflammatory response in the livers of rats with high-fat diet-induced NAFLD.
May 18, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Immunol. 2020 May 19 ;21(1):28. Epub 2020 May 19. PMID:
32429849
Article Published Date
: May 18, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
High Fat Diet
,
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
[+]
Berberine might be a preferable and rational therapeutic approach to ameliorate neuronal injury from hypoxia/ischemia.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Am J Transl Res. 2016 ;8(2):1197-207. Epub 2016 Feb 15. PMID:
27158406
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Autophagy Up-regulation
,
Neuroprotective Agents
[+]
Berberine might be a promising synergist to enhance the antimicrobial activity of azithromycin in vitro and in vivo.
Jul 23, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2017 Jul 24 ;42(4):1657-1669. Epub 2017 Jul 24. PMID:
28738346
Article Published Date
: Jul 23, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Pseudomonas aeruginosa
Pharmacological Actions
:
Antimicrobial
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Berberine might be useful for prevention of the hepatotoxicity induced by methotrexate.
Oct 25, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Oct 26 ;97:233-239. Epub 2017 Oct 26. PMID:
29091871
Article Published Date
: Oct 25, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Drug-Induced Toxicity: Methotrexate
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
,
Malondialdehyde Down-regulation
[+]
Berberine might become a new strategy for treating cardiac fibrosis in the future.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Clin Exp Pathol. 2015 ;8(10):12509-16. Epub 2015 Oct 1. PMID:
26722438
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Myocardial Fibrosis
Pharmacological Actions
:
Cardioprotective
[+]
Berberine might inhibit the progression of depression disorder by regulating the miR-34b-5p/miR-470-5p/BDNF axis.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Neuropsychiatr Dis Treat. 2021 ;17:613-626. Epub 2021 Feb 22. PMID:
33654403
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
,
Brain-derived neurotrophic factor modulator
,
MicroRNA modulator
[+]
Berberine might provide a combinational therapy for controlling hyperglycemia and blood pressure in diabetes.
May 16, 2017
Click here to read the entire abstract
Pubmed Data
: J Mol Endocrinol. 2017 May 17. Epub 2017 May 17. PMID:
28515053
Article Published Date
: May 16, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hyperglycemia
,
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
,
Hypoglycemic Agents
[+]
Berberine mitigates nonalcoholic hepatic steatosis.
Sep 01, 2021
Click here to read the entire abstract
Pubmed Data
: J Integr Med. 2021 Sep 2. Epub 2021 Sep 2. PMID:
34686466
Article Published Date
: Sep 01, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
,
SIRT1 Activator
[+]
Berberine modulates deacetylation of PPARγ to promote adipose tissue remodeling and thermogenesis.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Biol Sci. 2021 ;17(12):3173-3187. Epub 2021 Jul 25. PMID:
34421358
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
Berberine modulates GLP-1 via promoting GLP-1 secretion and GLP-1 biosynthesis.
Dec 01, 1995
Click here to read the entire abstract
Pubmed Data
: J Altern Complement Med. 1995 Winter;1(4):361-9. PMID:
19945441
Article Published Date
: Dec 01, 1995
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Pharmacological Actions
:
Glucagon Like peptide 1 (GLP-1) Up-regulation
[+]
Berberine modulates hyper-inflammation.
May 27, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2021 May 28 ;11(1):11298. Epub 2021 May 28. PMID:
34050236
Article Published Date
: May 27, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Berberine nanoencapsulation attenuates hallmarks of scoplomine induced Alzheimer's-like disease.
Jun 27, 2020
Click here to read the entire abstract
Pubmed Data
: Curr Clin Pharmacol. 2020 Jun 28. Epub 2020 Jun 28. PMID:
32598269
Article Published Date
: Jun 27, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Berberine or zinc protect against methotrexate-induced intestinal damage.
Jun 23, 2021
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2021 Jun 24 ;281:119754. Epub 2021 Jun 24. PMID:
34174323
Article Published Date
: Jun 23, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Zinc
Diseases
:
Drug Toxicity: Methotrexate
Pharmacological Actions
:
Gastroprotective
[+]
Berberine possesses neuro-protective and antioxidative potentials and normalize neurochemical impairment distort by diabetes.
Mar 15, 2021
Click here to read the entire abstract
Pubmed Data
: J Basic Clin Physiol Pharmacol. 2021 Mar 16. Epub 2021 Mar 16. PMID:
33725758
Article Published Date
: Mar 15, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes: Cognitive Dysfunction
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
Berberine prevents non-alcoholic steatohepatitis-derived hepatocellular carcinoma.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Am J Transl Res. 2019 ;11(5):2668-2682. Epub 2019 May 15. PMID:
31217846
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Liver Cancer
,
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-Inflammatory Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
[+]
Berberine prevents stress-induced gut inflammation and visceral hypersensitivity and reduces intestinal motility in rats.
Aug 06, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: World J Gastroenterol. 2019 Aug 7 ;25(29):3956-3971. PMID:
31413530
Article Published Date
: Aug 06, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Gastrointestinal Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-10 upregulation
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
[+]
Berberine prevents the progression of type 1 diabetes in mice through decreased Th17 and Th1 cytokine secretion.
Oct 09, 2009
Click here to read the entire abstract
Pubmed Data
: J Biol Chem. 2009 Oct 9;284(41):28420-9. Epub 2009 Aug 6. PMID:
19661066
Article Published Date
: Oct 09, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Autoimmune Diseases
,
Immune Dysregulation: TH17 over-expression
,
Immune Dysregulation: TH1 dominance
[+]
Berberine prevents ulcerative colitis by modifying gut microbiota and regulating the balance of Treg/Th17.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Front Pharmacol. 2018 ;9:571. Epub 2018 May 31. PMID:
29904348
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Immunomodulatory: Th17 downregulation
Additional Keywords
:
Microbiota
[+]
Berberine produced myocardial salvaging effects in the setting of diabetes challenged with ISP induced myocardial necrosis.
Feb 29, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Clin Diagn Res. 2016 Mar ;10(3):FF13-8. Epub 2016 Mar 1. PMID:
27134894
Article Published Date
: Feb 29, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
,
Diabetic Complications
,
Heart Failure
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
[+]
Berberine produces antidepressant-like effects in ovariectomized mice.
May 01, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2017 May 2 ;7(1):1310. Epub 2017 May 2. PMID:
28465511
Article Published Date
: May 01, 2017
Study Type
: Insect Study
Additional Links
Substances
:
Berberine
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
[+]
Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats.
Feb 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Endocrinol. 2009 Feb;200(2):159-65. Epub 2008 Nov 7. PMID:
18996945
Article Published Date
: Feb 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Glucagon Like peptide 1 (GLP-1) Up-regulation
,
Hypoglycemic Agents
[+]
Berberine promotes glucose uptake and inhibits gluconeogenesis by inhibiting deacetylase SIRT3.
Aug 15, 2018
Click here to read the entire abstract
Pubmed Data
: Endocrine. 2018 Aug 16. Epub 2018 Aug 16. PMID:
30117113
Article Published Date
: Aug 15, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Hypoglycemic Agents
[+]
Berberine promotes neurite extension and axonal regeneration in injured nerves of the peripheral nervous system
Apr 01, 2012
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2012 Apr ;15(4):413-7. Epub 2012 Feb 8. PMID:
22316297
Article Published Date
: Apr 01, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Goldenthread
Diseases
:
Demyelinating Diseases
,
Peripheral Nerve Diseases
,
Peripheral Neuropathies
Pharmacological Actions
:
Neuritogenic
Additional Keywords
:
Nerve Regeneration
,
Remyelination
,
Sciatic Nerve
[+]
Berberine protects against chronic cerebral hypoperfusion-induced cognitive impairment and hippocampal damage.
Jun 09, 2022
Click here to read the entire abstract
Pubmed Data
: J Chem Neuroanat. 2022 Jun 10:102119. Epub 2022 Jun 10. PMID:
35697268
Article Published Date
: Jun 09, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cerebral Hypoperfusion
Pharmacological Actions
:
Antioxidants
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Neuroprotective Agents
,
Nrf2 activation
,
Vascular Endothelial Growth Factor A Inhibitor
[+]
Berberine protects against diclofenac sodium-induced testicular impairment.
May 31, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran J Basic Med Sci. 2022 Jun ;25(6):767-774. PMID:
35949309
Article Published Date
: May 31, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
Problem Substances
:
Diclofenac
[+]
Berberine protects against fructose-and-salt induced hypertensive renal injury.
Mar 01, 2011
Click here to read the entire abstract
Pubmed Data
: Zhong Yao Cai. 2011 Mar ;34(3):412-5. PMID:
21823461
Article Published Date
: Mar 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Fructose-Induced Toxicity
,
Hypertension: Renal
,
Kidney Diseases
Pharmacological Actions
:
Renoprotective
Problem Substances
:
Fructose
,
Sodium Chloride
Adverse Pharmacological Actions
:
Nephrotoxic
[+]
Berberine protects against gastrointestinal injuries from alcohol stress.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(7):e0134044. Epub 2015 Jul 30. PMID:
26226164
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alcohol Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Gastroprotective
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine protects against neurological impairments and blood-brain barrier injury.
Dec 22, 2021
Click here to read the entire abstract
Pubmed Data
: Neuroimmunomodulation. 2021 Dec 23:1-10. Epub 2021 Dec 23. PMID:
34942622
Article Published Date
: Dec 22, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cerebral Hemorrhage
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine protects against simulated ischemia/reperfusion injury-induced H9C2 cardiomyocytes apoptosis.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2020 ;11:367. Epub 2020 Mar 27. PMID:
32292345
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Cardioprotective
