Berberine

Name	AC	CK
Insulin Resistance	23	92
Obesity	24	89
Diabetes Mellitus: Type 2	33	77
Inflammation	24	71
Hyperlipidemia	14	58
Dyslipidemias	3	41
C-Reactive Protein	2	40
Polycystic Ovary Syndrome	9	40
Breast Cancer	19	39
Cancers: All	18	38
Alzheimer's Disease	25	37
Helicobacter Pylori Infection	6	37
Lung Cancer	10	33
Nonalcoholic fatty liver disease (NAFLD)	17	31
Liver Cancer	20	25
Colorectal Cancer	10	24
Diabetic Complications	8	24
High Cholesterol	2	22
Hypercholesterolemia	3	22
Triglycerides: Elevated	2	22
Lipopolysaccharide-Induced Toxicity	14	21
Myocardial Ischemia	7	20
Colon Cancer	13	18
Osteoporosis	6	18
Rheumatoid Arthritis	8	18
Metabolic Diseases	6	17
Colitis	8	15
Diabetic Nephropathy	7	14
Atherosclerosis	8	13
Breast Cancer: Triple Negative	11	13
Cerebral Ischemia	7	13
High Fat Diet	7	13
Hyperglycemia	8	13
Ulcerative Colitis	8	13
Brain Inflammation	6	12
Depression	6	12
Endothelial Dysfunction	2	12
Fatty Liver	2	12
Kidney Diseases	2	12
Oxidative Stress	8	12
Diarrhea	2	11
Gastric Cancer	9	11
Glioblastoma	8	11
Atrial Fibrillation	1	10
Bacterial Vaginosis	1	10
Cognitive Decline/Dysfunction	5	10
Gastrointestinal Diseases	1	10
Osteosarcoma	5	10
Pancreatitis	6	10
Radiation Induced Illness	1	10
Sepsis	5	9
Cancers: Drug Resistant	7	8
Chemically-Induced Liver Damage	4	8
Heart Failure	5	8
Hypertension	5	8
Ischemia	5	8
Metabolic Syndrome X	4	8
Arthritis	4	7
Diabetes Mellitus: Type 1	4	7
Diabetes: Cognitive Dysfunction	4	7
Diabetic Neuropathy	4	7
Neurodegenerative Diseases	6	7
Carcinoma: Non-Small-Cell Lung	5	6
Cardiomyopathy	3	6
Cardiovascular Diseases	5	6
Epilepsy	3	6
Hypoxia	4	6
Melanoma	6	6
Ovarian Cancer	6	6
Autoimmune Diseases	3	5
Candida Albicans	5	5
Cervical Cancer	5	5
Chemotherapy-Induced Toxicity: Doxorubicin	3	5
Glioma	4	5
Influenza	3	5
Peripheral Neuropathies	3	5
Psoriasis	1	5
Acetaminophen (Tylenol) Toxicity	2	4
Advanced Glycation End products (AGE)	3	4
Alcohol Toxicity	2	4
Allergic Rhinitis	2	4
Asthma	3	4
Chemotherapy-Induced Toxicity: Paclitaxel	2	4
Chikungunya Virus	3	4
Enterocolitis: Necrotiziing	2	4
Fibrosis	2	4
Fructose-Induced Toxicity	2	4
Gastritis	2	4
Kidney Damage: Drug-Induced	2	4
Myocardial Infarction	2	4
Nasopharyngeal Cancer	3	4
Periodontitis	2	4
Prostatic Hyperplasia: Benign	2	4
Pseudomonas aeruginosa	3	4
Traumatic Brain Injury	2	4
Acute T cell Leukemias	3	3
Brain Ischemia	2	3
Brain: Oxidative Stress	2	3
Cancer Metastasis	3	3
Coxsackievirus Infections	2	3
Dementia	2	3
Diabetes: Oxidative Stress	2	3
Diabetic Retinopathy	3	3
Endometrial Cancer	2	3
Escherichia coli Infections	2	3
Hepatic Steatosis	2	3
Hydrogen Peroxide Induced Toxicity	3	3
Hypoglycemia	2	3
Leishmaniasis	2	3
Liver Fibrosis	2	3
Spinal Cord Injuries	2	3
Uveitis	2	3
Acute Respiratory Distress Syndrome	1	2
Adenomyosis	2	2
Aging	1	2
Aging: Brain	1	2
Alcoholic Liver Disease	1	2
Aluminum Toxicity	1	2
Aneurysm: Cerebral	1	2
Anxiety	1	2
Arsenic Poisoning	1	2
Arterial Hardening: Elasticity	1	2
Atopic Dermatitis	1	2
Autism	1	2
Bladder Dysfunction	1	2
Blood-Brain-Barrier Disorders	1	2
Bone Diseases	1	2
Brain Injury: Traumatic	1	2
Breast Cancer: Chemically-Induced	1	2
Bubonic Plague	1	2
Candida Infection	2	2
Cardiac Hypertrophy	1	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Chronic Myeloid Leukemia	1	2
Cocaine Withdrawal	1	2
Colon Cancer: Prevention	1	2
Colorectal Cancer: Prevention	1	2
Colorectal Tumors	1	2
Congestive Heart Failure	1	2
Convulsions	1	2
Coronavirus Infection	2	2
Cytomegalovirus Infections	2	2
Degenerative Disk Disease	2	2
Demyelinating Diseases	1	2
Diabesity	1	2
Diabetic Neuropathies	1	2
Diarrhea: Drug-Associated	1	2
Drug-Induced Toxicity: Gastrointestinal	1	2
Drug-Induced Toxicity: L-Thyroxine	1	2
Drug-Induced Toxicity: Methotrexate	1	2
Endothelial Damage	1	2
Erectile Dysfunction	1	2
Fetal Origin of Adult Disease	1	2
Gastric Polyposis	1	2
Gastrointestinal Inflammation	1	2
Graft vs Host Disease	1	2
HIV Infections	2	2
Heavy Metal Toxicity	1	2
Hepatitis: Autoimmune	1	2
High Homocysteine	1	2
Huntington Disease	1	2
Hyperalgesia	1	2
Hypersensitivity: Type IV	1	2
Hypertension: Pulmonary	1	2
Hypertension: Renal	1	2
Hyperuricemia	1	2
Immune Dysregulation: TH1 dominance	1	2
Immune Dysregulation: TH17 over-expression	1	2
Infertility: Male	1	2
Insomnia	1	2
Intestinal Permeability	1	2
Intestinal Polyps	1	2
Intima Media Thickening	1	2
Iron Overload	1	2
Irritable Bowel Syndrome	1	2
Kidney Fibrosis	1	2
Lead Poisoning	1	2
Learning disorders	1	2
Leukemia	2	2
Lipid Peroxidation	1	2
Liver Steatosis	1	2
Liver Stress: Fructose-Induced	1	2
Lung Cancer: Prevention	1	2
Malignant Melanoma	2	2
Mastitis	1	2
Memory Disorders: Drug-Induced	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Miscarriage	1	2
Morphine Tolerance/Dependence	1	2
Mucositis	1	2
Multiple Myeloma	2	2
Multiple Sclerosis	1	2
Muscle Damage: Exercise-Induced	1	2
Myocardial Fibrosis	1	2
Myocarditis: Viral	1	2
Nerve Injuries	1	2
Neuroblastoma	2	2
Neuropathic Pain	1	2
Non-Small-Cell Lung Carcinoma	2	2
Osteoarthritis	2	2
Pancreatic Cancer	2	2
Parkinson's Disease	1	2
Peripheral Nerve Diseases	1	2
Pesticide Toxicity	1	2
Post-Traumatic Stress Disorders (PTSD)	1	2
Postmenopausal Disorders	1	2
Postoperative Recovery	1	2
Prehypertension	1	2
Promyelocytic leukemia	2	2
Prostate Cancer	2	2
Psychiatric Disorders	1	2
Retinal Diseases	1	2
Schizophrenia	1	2
Seizures	1	2
Seizures: Drug-Induced	1	2
Smoking Cessation: Nicotine Addiction	1	2
Staphylococcal Infections	1	2
Staphylococcus aureus infection	2	2
Staphylococcus aureus: Methicillin-resistant (MRSA)	2	2
Stroke: Ischemic	1	2
Tongue Cancer	1	2
Uremia	1	2
Uveoretinitis	1	2
Varicocele	1	2
Acute Myeloid Leukemia	1	1
Acute lymphoblastic leukemia (ALL)	1	1
Allergic Airway Diseases	1	1
Allergies	1	1
Alphavirus Infections	1	1
Arthritis: Rheumatoid	1	1
Bacillus Cereus infection	1	1
Bacterial Infections and Mycoses	1	1
Bladder Cancer	1	1
Breast Cancer Stem Cells	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Cancer: Virus-Induced	1	1
Cancers: Multi-Drug Resistant	1	1
Cardiac Arrhythmias	1	1
Chemotherapy-Induced Kidney Damage	1	1
Chemotherapy-Induced Toxicity: Cisplatin	1	1
Cholangiocarcinoma	1	1
Cholesterol: Oxidation	1	1
Chondrosarcoma	1	1
Chronic Disease	1	1
Chronic Kidney Disease (CKD)	1	1
Chronic Lymphocytic Leukemia	1	1
Chronic Obstructive Pulmonary Disease	1	1
Clostridium Infections	1	1
Corticosteroid-Induced Toxicity	1	1
Dementia: Senile	1	1
Dental Caries	1	1
Diabetes Mellitus: Type 2: Prevention	1	1
Diabetes: Glycation/A1C	1	1
Diabetes: Kidney Function	1	1
Diarrhea: in Children	1	1
Dysbiosis	1	1
Echinococcosis	1	1
Enterococcus Infections	1	1
Enterovirus 71	1	1
Enterovirus: Type 71	1	1
Esophageal Cancer	1	1
Eye Diseases	1	1
Friend Virus	1	1
Fungal Infection	1	1
Gastrointestinal Cancer	1	1
HIV Drug-Induced Toxicity	1	1
Head and Neck Cancer	1	1
Herpes Simplex Virus Type 1	1	1
Herpes Simplex Virus Type 2	1	1
High Sugar Diet	1	1
Human Papillomavirus (HPV)	1	1
Hydatid Cyst	1	1
Inflammatory Bowel Diseases	1	1
Kawasaki Disease	1	1
Kidney Cancer	1	1
Kidney Damage	1	1
Laryngeal Cancer	1	1
Leaky Gut Syndrome	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Leukemia: Chronic Lymphocytic Leukemia (CLL)	1	1
Leukemia: Virus-Induced	1	1
Liver Damage	1	1
Lower Respiratory Infections	1	1
Lung Injury: Acute	1	1
Lymphangioendothelioma	1	1
Macular Degeneration	1	1
Mesothelioma	1	1
Microcystis aeruginosa	1	1
Myocarditis: Autoimmune	1	1
Oral Cancer	1	1
Overweight	1	1
Periodontal Diseases	1	1
Pulmonary Fibrosis	1	1
Respiratory Syncytial Virus Infections	1	1
Retinoblastoma	1	1
Rhabdomyosarcoma	1	1
Salmonella Infections	1	1
Skin Cancer: Squamous Cell	1	1
Squamous cell carcinoma	1	1
Streptococcus pyogenes	1	1
Subarachnoid hemorrhage	1	1
Thrombocytopenia	1	1
Thyroid Cancer	1	1

Name	AC	CK
Anti-Inflammatory Agents	134	266
Antiproliferative	79	116
Hypolipidemic	28	114
Antioxidants	64	107
Tumor Necrosis Factor (TNF) Alpha Inhibitor	45	99
Interleukin-6 Downregulation	43	93
Neuroprotective Agents	54	87
Apoptotic	62	72
Gastrointestinal Agents	25	71
Cardioprotective	28	64
Anticholesteremic Agents	9	60
Chemopreventive	23	59
Interleukin-1 beta downregulation	33	56
Hepatoprotective	29	54
Anti-Apoptotic	29	53
Hypoglycemic Agents	21	53
Anti-Bacterial Agents	12	42
NF-kappaB Inhibitor	28	41
MicroRNA modulator	27	39
Anti-metastatic	27	30
Renoprotective	16	27
Cell cycle arrest	23	26
Chemotherapeutic	22	24
Insulin Sensitizers	7	21
Chemosensitizer	18	19
Cyclooxygenase 2 Inhibitors	11	18
Autophagy Up-regulation	11	17
Gastroprotective	8	16
Immunomodulatory	12	16
Nrf2 activation	11	16
Antidiarrheals	4	14
Antineoplastic Agents	5	13
Antiviral Agents	11	13
Chemoprotective Agents	8	13
Anti-Fibrotic	7	12
Anticarcinogenic Agents	7	12
Matrix metalloproteinase-2 (MMP-2) inhibitor	10	12
Matrix metalloproteinase-9 (MMP-9) inhibitor	8	11
Antihypertensive Agents	6	10
Osteoprotective	6	10
Radioprotective	1	10
Antidepressive Agents	4	8
Antimicrobial	7	8
Interleukin-10 upregulation	4	8
Malondialdehyde Down-regulation	4	8
Pancreato Protective Agents	5	8
Tumor Suppressor Protein p53 Upregulation	7	8
Wnt/β-catenin signaling pathway modulation	7	8
Angiogenesis Inhibitors	5	7
Angiogenesis Inducing Agents	3	6
Anti-Adipogenic	5	6
Anti-Anxiety Agents	3	6
Anticonvulsants	3	6
Cytoprotective	4	6
Enzyme Inhibitors	2	6
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	5	6
Immunomodulatory: Th17 downregulation	3	6
STAT3 Inhibitor	4	5
Analgesics	2	4
Antifungal Agents	4	4
Bcl-2 protein down-regulation	4	4
Brain-derived neurotrophic factor modulator	2	4
Glucagon Like peptide 1 (GLP-1) Up-regulation	2	4
Heme oxygenase-1 up-regulation	3	4
Interleukin-10 downregulation	2	4
Interleukin-17 downregulation	2	4
Prostaglandin PGE2 downregulation	2	4
Radiosensitizer	3	4
Regenerative	3	4
Transforming growth factor beta (TGF-β) inhibitor	2	4
Vasoprotective	2	4
Anti-Glycation Agents	2	3
Anti-atherogenic	2	3
Caspase-3 Activation	2	3
Interleukin-8 downregulation	3	3
Matrix metalloproteinase-3 (MMP-3) inhibitor	2	3
Vascular Endothelial Growth Factor Inhibitors	3	3
Alpha-glucosidase inhibitor	2	2
Anti-Tumor	1	2
Bax/Bcl2 Ratio: Decrease	1	2
Caspase-9 Activation	1	2
Cholinesterase Inhibitors	1	2
Cytotoxic	2	2
Enzyme Inhibitors: Pancreatic Amylase	1	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Fertility Agents: Male	1	2
Fibroblast growth factor 21 upregulation	1	2
Immunosuppressive Agents	1	2
Interferon Gamma Reducer	1	2
Interleukin-1 alpha downregulation	2	2
Interleukin-4 downregulation	1	2
Interleukin-4 upregulation	1	2
Iron Chelating Agents	1	2
Leishmanicidal	1	2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	2	2
Neuritogenic	1	2
Nitric Oxide Inhibitor	1	2
P21 Activation	2	2
Photosensitizing Agents	2	2
SIRT1 Activator	1	2
Uricosuric Agents	1	2
Wnt/β-catenin pathway down-regulation	1	2
interleukin-13 down-regulation	1	2
AMP-activated protein kinase modulation	1	1
Acetylcholinesterase Inhibitor	1	1
Alpha-amylase inhibitor	1	1
Anti-Allergic Agents	1	1
Anti-Androgen	1	1
Anti-Proliferative	1	1
Antioxidant Effects	1	1
Autophagy Inhibitors	1	1
Cyclin D1 Down-Regulation	1	1
Cyclin-dependent kinase inhibitor: P16INK4	1	1
Expectorants	1	1
Gluconeogenesis Inhibitor	1	1
HIV Protease Inhibitors	1	1
Interleukin-18 down-regulation	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
Multidrug Resistance Gene Modulators	1	1
Osteogenic	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
Prophylactic Agents	1	1
RANK Downregulation	1	1
Scolicidal	1	1
Survivin Down-Regulation	1	1
Telomerase Inhibitor	1	1

Pharmacological Actions : Hypolipidemic

Additional Keywords : Anti-Obesity Agents

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Berberine exerted anti-tumor effects in a variety of tumors in vivo.Jun 16, 2019

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Berberine exhibits antioxidative effects and reduces apoptosis of the vaginal epithelium in bacterial vaginosis.Aug 31, 2019

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Pubmed Data : Exp Ther Med. 2019 Sep ;18(3):2122-2130. Epub 2019 Jul 12. PMID: 31410167

Article Published Date : Aug 31, 2019

Study Type : Human Study

Additional Links

Substances : Berberine

Diseases : Bacterial Vaginosis

Pharmacological Actions : Anti-Apoptotic, Antioxidants

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Berberine improves diabetic kidney disease by reducing UACR and serum Cys C in T2DM patients.Dec 10, 2018

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 2018 Dec 11 ;98(46):3756-3761. PMID: 30541217

Article Published Date : Dec 10, 2018

Study Type : Human Study

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Substances : Berberine

Diseases : Diabetic Complications, Kidney Diseases

[+]

Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy.Feb 01, 2007

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Pubmed Data : J Forensic Leg Med. 2007 Feb;14(2):87-91. PMID: 19757213

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Pubmed Data : Evid Based Complement Alternat Med. 2009 Oct 6; PMID: 19800084

Article Published Date : Oct 06, 2009

Study Type : Human Study

Additional Links

Substances : Berberine

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Drug: Metformin, Drug: Rosiglitazone, Insulin Receptor Upregulation, Natural Substances Versus Drugs

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Berberine possesses potential lipid-regulating, antiarthritis, and synovial hyperplasia inhibition activities against rheumatoid arthritis.Dec 31, 2018

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The role of serum inflammatory cytokines and berberine in the insulin signaling pathway among women with polycystic ovary syndrome.Dec 31, 2019

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Pubmed Data : PLoS One. 2020 ;15(8):e0235404. Epub 2020 Aug 12. PMID: 32785222

Article Published Date : Dec 31, 2019

Study Type : Human Study

Additional Links

Substances : Berberine

Diseases : Insulin Resistance, Polycystic Ovary Syndrome

Pharmacological Actions : Anti-Inflammatory Agents, Insulin Sensitizers

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Berberine can significantly inhibit the activity of N-acetyltransferase in human lung cancer cell line A549.May 31, 2014

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Pubmed Data : PLoS One. 2015 ;10(5):e0123478. Epub 2015 May 8. PMID: 25954974

Article Published Date : Dec 31, 2014

Study Type : Animal Study, In Vitro Study

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Substances : Berberine

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Prostaglandin PGE2 downregulation

[+]

Berberine attenuates the abnormal ectopic lipid deposition in skeletal muscle.Jul 30, 2020

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Pubmed Data : Free Radic Biol Med. 2020 Jul 31. Epub 2020 Jul 31. PMID: 32745766

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Pubmed Data : Front Immunol. 2020 ;11:588079. Epub 2020 Sep 24. PMID: 33072135

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Colorectal Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

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A relatively low dose berberine exhibited strong neuroprotective activity against 6-OHDA-induced neurotoxicity in PC12 cells.Nov 03, 2016

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Pubmed Data : Chem Biol Interact. 2018 Aug 21 ;294:91-100. Epub 2018 Aug 21. PMID: 30138605

Article Published Date : Aug 20, 2018

Study Type : Animal Study

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Substances : Berberine

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective

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Autologous erythrocytes delivery of berberine hydrochloride with long-acting effect for hypolipidemia treatment.Nov 30, 2020

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Pubmed Data : Drug Deliv. 2020 Dec ;27(1):283-291. PMID: 32013620

Article Published Date : Nov 30, 2020

Study Type : Animal Study

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Substances : Berberine

Diseases : Hyperlipidemia

Pharmacological Actions : Hypolipidemic

[+]

Berbamine induces programmed cell death in human liver cancer cells and inhibits tumor growth in mice. Jan 01, 2009

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Pubmed Data : J Asian Nat Prod Res. 2009;11(3):219-28. PMID: 19408145

Article Published Date : Jan 01, 2009

Study Type : Animal Study

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Substances : Berberine

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation

[+]

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Pubmed Data : Andrologia. 2018 Oct 17:e13179. Epub 2018 Oct 17. PMID: 30334274

Article Published Date : Oct 16, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Varicocele

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Berberine ameliorates hepatic insulin resistance by regulating microRNA-146b/SIRT1 pathway.Dec 31, 2020

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Pubmed Data : PLoS One. 2015 ;10(8):e0134172. Epub 2015 Aug 7. PMID: 26252777

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Metabolic Diseases, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

Additional Keywords : Gene Expression Regulation

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Berberine ameliorates NSAIDs-induced intestinal injury by the repair of enteric nervous system.Sep 12, 2019

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Pubmed Data : Fundam Clin Pharmacol. 2019 Sep 13. Epub 2019 Sep 13. PMID: 31520444

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Pubmed Data : Front Cell Neurosci. 2020 ;14:87. Epub 2020 Apr 9. PMID: 32327976

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Pubmed Data : Ann Hepatobiliary Pancreat Surg. 2021 Jun 30 ;25(Suppl 1):S399. PMID: 34230296

Article Published Date : Jun 29, 2021

Study Type : Animal Study

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Substances : Berberine

Diseases : Colorectal Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

[+]

Berberine attenuates arterial plaque formation.Dec 31, 2019

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Pubmed Data : J Cell Physiol. 2019 Feb 20. Epub 2019 Feb 20. PMID: 30786011

Article Published Date : Feb 19, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Hypertension, Hypoxia

Pharmacological Actions : Antihypertensive Agents

[+]

Berberine attenuates intestinal tumorigenesis by inhibiting the migration and invasion of colorectal tumor cells.Dec 31, 2015

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Pubmed Data : Free Radic Biol Med. 2019 Jun 18 ;141:192-204. Epub 2019 Jun 18. PMID: 31226399

Article Published Date : Jun 17, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

[+]

Berberine attenuates olanzapine induced-metabolic syndrome.Jul 31, 2019

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Pubmed Data : J Pak Med Assoc. 2019 Aug ;69(Suppl 3)(8):S88-S92. PMID: 31603885

Article Published Date : Jul 31, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Metabolic Diseases

Pharmacological Actions : Hypolipidemic

Problem Substances : Olanzapine

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Berberine can improve insulin resistance of skeletal muscle in rats. Oct 31, 2015

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Pubmed Data : Sichuan Da Xue Xue Bao Yi Xue Ban. 2015 Nov ;46(6):827-31. PMID: 26867315

Article Published Date : Oct 31, 2015

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Insulin Resistance

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Berberine can improve myocardial injury and cardiac function in sepsis.Sep 21, 2020

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 2020 Sep 22 ;100(35):2779-2784. PMID: 32972060

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Pubmed Data : Avicenna J Phytomed. 2016 Mar-Apr;6(2):198-204. PMID: 27222833

Article Published Date : Feb 29, 2016

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Morphine Tolerance/Dependence

[+]

Berberine can reverse chronic inflammatory pain induced by complete freund's adjuvant and alleviated the comorbid depression.Apr 09, 2018

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 2018 Apr 10 ;98(14):1103-1108. PMID: 29690724

Article Published Date : Apr 09, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Depression, Hyperalgesia, Inflammation

Pharmacological Actions : Analgesics, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Berberine can suppress the proliferation of liver cancer cells by reducing SLC1A5 expression.Dec 31, 2018

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Pubmed Data : Cancer Chemother Pharmacol. 2020 Jul ;86(1):151-161. Epub 2020 Jun 30. PMID: 32607786

Article Published Date : Jun 30, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Antiproliferative

[+]

Berberine clears Aβ deposit and consequently ameliorates spatial learning memory impairment.Dec 31, 2018

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Pubmed Data : Diabetes Metab Syndr Obes. 2020 ;13:4561-4569. Epub 2020 Nov 23. PMID: 33262628

Article Published Date : Dec 31, 2019

Study Type : Animal Study

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Substances : Berberine

Diseases : Insulin Resistance

Pharmacological Actions : Anti-Inflammatory Agents

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Berberine enhances L1 expression and axonal remyelination in rats after brachial plexus root avulsion.Aug 06, 2020

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Pubmed Data : Brain Behav. 2020 Aug 7:e01792. Epub 2020 Aug 7. PMID: 32770668

Article Published Date : Aug 06, 2020

Study Type : Animal Study

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Substances : Berberine

Diseases : Nerve Injuries

Pharmacological Actions : Regenerative

Additional Keywords : Nerve Regeneration

[+]

Berberine exerted a protective effect on gut-vascular barrier function in sepsis.Sep 10, 2018

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Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:1319-1326. Epub 2018 May 7. PMID: 29864914

Berberine impairs coxsackievirus B3-induced myocarditis through the inhibition of virus replication and host pro-inflammatory response.Dec 17, 2020

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Pubmed Data : J Med Virol. 2020 Dec 18. Epub 2020 Dec 18. PMID: 33336842

Article Published Date : Dec 17, 2020

Study Type : Animal Study

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Substances : Berberine

Diseases : Coxsackievirus Infections, Myocarditis: Viral

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective

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Pharmacological Actions : Anti-Tumor, Apoptotic, Cell cycle arrest, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Berberine inhibited angiogenesis in glioblastoma xenografts.Nov 30, 2018

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Pubmed Data : Sci Rep. 2016 ;6:20848. Epub 2016 Feb 9. PMID: 26857750

Article Published Date : Dec 31, 2015

Study Type : Animal Study, In Vitro Study

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Substances : Berberine

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

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Berberine may be a potential therapeutic agent for the treatment of patients with neonatal necrotizing enterocolitis.Mar 31, 2018

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Pubmed Data : Mol Med Rep. 2017 May ;15(5):2765-2787. Epub 2017 Mar 14. PMID: 28447763

Article Published Date : Apr 30, 2017

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Insulin Resistance, Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Gastrointestinal Agents

Additional Keywords : Microbiota

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Pubmed Data : J Altern Complement Med. 1995 Winter;1(4):361-9. PMID: 19945441

Article Published Date : Dec 01, 1995

Study Type : Animal Study

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Substances : Berberine

Pharmacological Actions : Glucagon Like peptide 1 (GLP-1) Up-regulation

[+]

Berberine modulates hyper-inflammation.May 27, 2021

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Pubmed Data : Sci Rep. 2021 May 28 ;11(1):11298. Epub 2021 May 28. PMID: 34050236

Article Published Date : May 27, 2021

Study Type : Animal Study

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Substances : Berberine

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Berberine nanoencapsulation attenuates hallmarks of scoplomine induced Alzheimer's-like disease.Jun 27, 2020

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Pubmed Data : Curr Clin Pharmacol. 2020 Jun 28. Epub 2020 Jun 28. PMID: 32598269

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Pubmed Data : World J Gastroenterol. 2019 Aug 7 ;25(29):3956-3971. PMID: 31413530

Article Published Date : Aug 06, 2019

Study Type : Animal Study

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Substances : Berberine

Diseases : Gastrointestinal Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor

[+]

Berberine prevents the progression of type 1 diabetes in mice through decreased Th17 and Th1 cytokine secretion. Oct 09, 2009

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Pubmed Data : Zhong Yao Cai. 2011 Mar ;34(3):412-5. PMID: 21823461

Pubmed Data : Am J Chin Med. 2021 Jun 16:1-17. Epub 2021 Jun 16. PMID: 34137676

Article Published Date : Jun 15, 2021

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Diabetes: Cognitive Dysfunction

Pharmacological Actions : Neuroprotective Agents

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Pharmacological Actions : Anti-metastatic, Antiproliferative , Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation

[+]

Berberine suppresses influenza virus-triggered NLRP3 inflammasome activation in macrophages.Apr 08, 2020

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Pubmed Data : J Leukoc Biol. 2020 Apr 9. Epub 2020 Apr 9. PMID: 32272506

Article Published Date : Apr 08, 2020

Study Type : Animal Study, In Vitro Study

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Substances : Berberine

Diseases : Inflammation, Influenza

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Berberine treatment improved short-term memory in hyperlipidemia.Oct 31, 2019

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Pubmed Data : Int Neurourol J. 2019 Nov ;23(Suppl 2):S102-110. Epub 2019 Nov 30. PMID: 31795609

Article Published Date : Oct 31, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Brain Inflammation , Hyperlipidemia

Pharmacological Actions : Anti-Inflammatory Agents, Anticholesteremic Agents, Hypolipidemic

[+]

Berberine treatment reduced hepatic injury caused by concanavalin A.Dec 27, 2017

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Pubmed Data : Med Sci Monit. 2017 Dec 28 ;23:6150-6161. Epub 2017 Dec 28. PMID: 29283990

Article Published Date : Dec 27, 2017

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Pubmed Data : Rhinology. 2015 Aug 15. Epub 2015 Aug 15. PMID: 26275466

Article Published Date : Aug 14, 2015

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Allergic Rhinitis, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation, MicroRNA modulator

[+]

Berberine-loaded carboxylmethyl chitosan nanoparticles ameliorate DSS-induced colitis.Dec 31, 2020

Pubmed Data : Mol Med Rep. 2018 Sep ;18(3):3437-3444. Epub 2018 Jul 24. PMID: 30066867

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Cognitive Decline/Dysfunction, Pancreatitis

Pharmacological Actions : Neuroprotective Agents

[+]

Combination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced acute kidney injury.Mar 31, 2019

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Pubmed Data : Int J Crit Illn Inj Sci. 2019 Apr-Jun;9(2):69-74. PMID: 31334048

Article Published Date : Mar 31, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Diclofenac

[+]

Combination of berberine with resveratrol improves the lipid-lowering efficacy.Dec 05, 2018

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Pubmed Data : Int J Mol Sci. 2018 Dec 6 ;19(12). Epub 2018 Dec 6. PMID: 30563192

Article Published Date : Dec 05, 2018

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Pubmed Data : Iran J Basic Med Sci. 2020 Nov ;23(11):1480-1488. PMID: 33235706

Article Published Date : Oct 31, 2020

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Anxiety

Pharmacological Actions : Anti-Anxiety Agents

Problem Substances : Amphetamine

[+]

Enhancement of berberine hypoglycemic activity by oligomeric proanthocyanidins.Dec 13, 2018

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View the Evidence: 654 Abstracts with Berberine Research

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A nutraceutical combination has shown to be an effective product for the improvement of the lipid profile.Apr 26, 2016

Berberine and dyslipidemia: different applications and biopharmaceutical formulations without statin-like molecules.Aug 22, 2019

Berberine can improve obesity and hyperlipidemiaDec 31, 2020

Berberine exerted anti-tumor effects in a variety of tumors in vivo.Jun 16, 2019

Berberine showed a promising prospect in treating polycystic ovary syndrome patients with insulin resistance.Dec 31, 2017

Berberine supplementation may ameliorate the state of chronic inflammation.Sep 30, 2019

Systematic review and meta-analysis on efficacy and safety of berberine for dyslipidemiaJan 31, 2020

The addition of berberine in standard triple therapy could improve Helicobacter pylori eradication rate and clinical symptom remission rate.Dec 31, 2018

The results of the current study support the use of berberine supplementation for the improvement of obesity indices.Apr 30, 2020

These results found a significant reduction in waist-hip ratio following berberine consumption in adults.Feb 29, 2020

This meta-analysis found a significant reduction of body weight, BMI, WC and CRP levels associated with berberine intake.Jul 31, 2020

A combination of berberine, red yeast rice and policosanol lowers lipid levels and improves endothelial function and insulin sensitivity in hypercholesterolemic patients. Aug 19, 2009

A nutraceutical formula containing berberine, chlorogenic acid, and tocotrienols was found to improve a large number of metabolic and liver parameters in overweight subjects.Mar 28, 2015

Berberine Capsule was effective in improving blood lipid level in mild hyperlipidemia patients.May 31, 2016

Berberine containing quadruple therapy could be used for Helicobacter pylori eradication.Jul 31, 2017

Berberine exhibits antioxidative effects and reduces apoptosis of the vaginal epithelium in bacterial vaginosis.Aug 31, 2019

Berberine improves diabetic kidney disease by reducing UACR and serum Cys C in T2DM patients.Dec 10, 2018

Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy.Feb 01, 2007

Berberine is a potent oral hypoglycemic agent with benefical effects on lipid metabolism, comparable in efficacy to metformin. May 01, 2008

Berberine is efficacious for the treatment of atrial fibrillation.Dec 31, 2016

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.Oct 06, 2009

Berberine possesses potential lipid-regulating, antiarthritis, and synovial hyperplasia inhibition activities against rheumatoid arthritis.Dec 31, 2018

Berberine promoted myocardial protection of postoperative patients through regulating myocardial autophagy.Aug 31, 2018

Berberine was safe and effective in reducing the risk of recurrence of colorectal adenoma.Jan 07, 2020

Dry extracts of artichoke and berberine have beneficial effects in hypercholesterolemic patients.Feb 14, 2019

Hop rho iso-alpha acids, berberine, vitamin D(3) and vitamin K (1) favorably impact biomarkers of bone turnover in postmenopausal women. Dec 19, 2009

Role of a berberine-based nutritional supplement in reducing diarrhea in subjects with functional gastrointestinal disorders.Feb 29, 2020

The combined application of berberine in patients with metabolic syndrome can effectively regulate blood glucose and blood lipid of patients.Mar 31, 2019

The role of serum inflammatory cytokines and berberine in the insulin signaling pathway among women with polycystic ovary syndrome.Dec 31, 2019

Berberine can significantly inhibit the activity of N-acetyltransferase in human lung cancer cell line A549.May 31, 2014

Berberine induced apoptosis and DNA damage in human osteosarcoma lines that were treated.Sep 30, 2014

Berberine may serve as a potential therapeutic option for patients with psoriasis.Mar 19, 2019

These results suggest that berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokine profile in human preadipocytes and metabolic syndrome patients.Mar 07, 2012

Remission of new-onset type 2 diabetes mellitus in an adolescent using an integrative medicine approach.Oct 21, 2020

Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.Dec 31, 2014

Berberine attenuates the abnormal ectopic lipid deposition in skeletal muscle.Jul 30, 2020

Berberine improves neointima formation in a rat model.May 01, 2006

A berberine derivative attenuates cardiac failure. Feb 01, 2010

A holistic view of berberine inhibiting intestinal carcinogenesis.Dec 31, 2019

A relatively low dose berberine exhibited strong neuroprotective activity against 6-OHDA-induced neurotoxicity in PC12 cells.Nov 03, 2016

Administration of Berberis vulgaris could ameliorate neurotoxicity induced by beta amyloid. Jul 04, 2015

Ameliorating effects of berberine on MK-801-induced cognitive and motor impairments in a neonatal rat model of schizophrenia.May 15, 2019

Ameliorating ribosylation-induced amyloid-β pathology by berberine.Dec 22, 2020

Ameliorative effect of berberine on neonatally induced type 2 diabetic neuropathy.Jun 30, 2019

An inhibitory effect of Berberine from herbal Coptis chinensis Franch on rat detrusor contraction in benign prostatic hyperplasia associated with lower urinary tract symptoms.Dec 06, 2020

Anti-inflammation associated protective mechanism of berberine and its derivatives on attenuating pentylenetetrazole-induced seizures.Jan 05, 2020

Anti-influenza activity of berberine improves prognosis by reducing viral replication in mice.Oct 10, 2018

Anticolitic effect of berberine in rat experimental model.Dec 31, 2019

Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis.Aug 20, 2018

Autologous erythrocytes delivery of berberine hydrochloride with long-acting effect for hypolipidemia treatment.Nov 30, 2020

Berbamine induces programmed cell death in human liver cancer cells and inhibits tumor growth in mice. Jan 01, 2009

Berberine (a major constituent of goldenseal) has significant cholesterol-lowering action Dec 01, 2004

Berberine activates apoptosis to suppress triple-negative breast cancer cells.Aug 17, 2017

Berberine alleviated doxorubicin induced cardiotoxicity via inhibition of the metabolism of doxorubicin and reduced accumulation of doxorubicinol selectively in hearts.May 12, 2015

Berberine alleviates adipose tissue fibrosis.May 27, 2018

Berberine alleviates amyloid-beta pathogenesis.Mar 14, 2019

Berberine alleviates amyloid-beta pathology in the brain of APP/PS1 transgenic mice.Jun 30, 2018

Berberine alleviates dextran sodium sulfate-induced colitis.May 31, 2017

Berberine alleviates disease symptoms in mouse models mimicking the symptoms of IBS-D. Dec 31, 2014

Berberine alleviates endothelial glycocalyx degradation and promotes glycocalyx restoration in LPS-induced ARDS.Oct 07, 2018

Berberine alleviates hepatic lipid accumulation.Mar 01, 2018

Berberine alleviates hyperglycemia by targeting hepatic glucokinase.May 28, 2019

Berberine alleviates lipid metabolism disorders via inhibition of mitochondrial complex I in gut and liver.Dec 31, 2020

Berberine alleviates monosodium glutamate induced postnatal metabolic disorders associated vascular endothelial dysfunction.Feb 18, 2020

Berberine alleviates NASH and its predisposing factors.Feb 29, 2016

Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3.Mar 07, 2019

Berberine alleviates oxidative stress in islets of diabetic mice.Apr 23, 2017

Berberine alleviates oxidative stress in rats with osteoporosis.Oct 21, 2017

Berberine alleviates paclitaxel-induced neuropathy.May 31, 2019

Berberine alleviates symptoms of anxiety by enhancing dopamine expression in rats with post-traumatic stress disorder.Feb 28, 2018

Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression.Nov 25, 2019

Berberine ameliorates collagen-induced arthritis in rats by facilitating the generation of butyrate and adjusting the intestinal hypoxia and nitrate supply.Aug 18, 2019

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View the Evidence:
654 Abstracts with Berberine Research