Betulinic acid

Name	AC	CK
Chemotherapy-Induced Toxicity: Doxorubicin	1	5
Inflammation	1	5
Osteoarthritis	1	5
HIV Infections	2	2
Influenza A	1	2
Oxidative Stress	1	2
Prostate Cancer	2	2
Bladder Cancer	1	1
Breast Cancer	1	1
Breast Cancer: estrogen receptor alpha-positive	1	1
Cancers: All	1	1
Cancers: Drug Resistant	1	1
Colon Cancer	1	1
Diabetic Nephropathy	1	1
Hepatitis C	1	1
Leukemia: Chronic myelogenous leukemia (CML)	1	1
Lung Cancer	1	1
Lung Cancer: Metastatic	1	1
Ovarian Cancer	1	1
Promyelocytic leukemia	1	1

Name	AC	CK
Anti-Inflammatory Agents	3	8
Anti-Apoptotic	1	5
Chemoprotective Agents	1	5
Interleukin-1 beta downregulation	1	5
Apoptotic	4	4
Antiproliferative	3	3
Antiviral Agents	2	3
Anti-HIV Agents	2	2
Anti-metastatic	2	2
Antioxidants	1	2
Chemopreventive	2	2
Antimutagenic Agents	1	1
Antineoplastic Agents	1	1
Chemosensitizer	1	1
Cyclooxygenase 2 Inhibitors	1	1
Enzyme Inhibitors	1	1
Epidermal growth factor receptor (EGFR) inhibitor	1	1
Estrogen Receptor Modulators	1	1
NF-kappaB Inhibitor	1	1
Radiosensitizer	1	1

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Natural Substance Synergy

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A combination therapy of betulinic acid and fluvastatin that reduces the risk of both rheumatoid arthritis and CVD.Aug 31, 2017

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Pubmed Data : Biomed Pharmacother. 2017 Sep ;93:681-694. Epub 2017 Jul 8. PMID: 28692940

Article Published Date : Aug 31, 2017

Study Type : Animal Study

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Substances : Betulinic acid

Diseases : Arthritis, Cardiovascular Disease

Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Anti-inflammatory effect and potential mechanism of betulinic acid on λ-carrageenan-induced paw edema in mice.Sep 30, 2019

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Pubmed Data : Inflammopharmacology. 2019 Jul 27. Epub 2019 Jul 27. PMID: 31352642

Article Published Date : Jul 26, 2019

Study Type : Animal Study

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Substances : Betulinic acid

Diseases : Sepsis

Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation, Vasodilator Agents

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Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2020 Jan 8. Epub 2020 Jan 8. PMID: 31915810

Article Published Date : Jan 07, 2020

Study Type : Animal Study, In Vitro Study

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Substances : Betulinic acid

Diseases : Gallbladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

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Betulinic acid inhibits high-fat diet-induced obesity and improves energy balance by activating AMPK.Mar 31, 2019

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Pubmed Data : Nutr Metab Cardiovasc Dis. 2019 Apr ;29(4):409-420. Epub 2019 Jan 8. PMID: 30799179

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Pubmed Data : Nitric Oxide. 2011 Apr 30 ;24(3):132-8. Epub 2011 Feb 1. PMID: 21292018

Article Published Date : Apr 29, 2011

Study Type : Animal Study

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Substances : Betulinic acid

Diseases : Brain: Oxidative Stress, Brain Ischemia

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nitric Oxide Inhibitor

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Betulinic acid protects against cerebral ischemia-reperfusion injury.Sep 30, 2017

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Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2017 Oct ;37(5):744-749. Epub 2017 Oct 20. PMID: 29058289

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Pubmed Data : Open Access Maced J Med Sci. 2018 May 20 ;6(5):757-766. Epub 2018 May 15. PMID: 29875842

Article Published Date : May 19, 2018

Study Type : Animal Study

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Substances : Betulinic acid, Jujube

Diseases : Diarrhea

Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Antidiarrheals

Additional Keywords : Dose Response

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A derivative of betulinic acid may be a viable treatment for lung cancer metastasis, either alone or in combination, without causing damage to normal cells.May 29, 2015

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Pubmed Data : Med Res Rev. 2015 Jun 2. Epub 2015 Jun 2. PMID: 26032847

Article Published Date : Jun 01, 2015

Study Type : Review

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Substances : Betulinic acid

Diseases : Ovarian Cancer

Pharmacological Actions : Chemopreventive

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Betulinic acid and the pharmacological effects of tumor suppression.Oct 31, 2016

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Pubmed Data : Oncol Lett. 2018 Sep ;16(3):3628-3634. Epub 2018 Jul 6. PMID: 30127971

Article Published Date : Aug 31, 2018

Study Type : In Vitro Study

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Substances : Betulinic acid

Diseases : Cancers: Drug Resistant, Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

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Betulinic acid has anti-proliferative effects on canine cancers. Aug 31, 2018

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Pubmed Data : Oncol Rep. 2017 Oct ;38(4):2360-2368. Epub 2017 Aug 3. PMID: 28791404

Article Published Date : Sep 30, 2017

Study Type : In Vitro Study

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Substances : Betulinic acid

Diseases : Oral Cancer

Pharmacological Actions : Radiosensitizer

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Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma.Jun 28, 2010

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Pubmed Data : Oncol Res. 2017 Aug 7 ;25(7):1141-1152. Epub 2017 Jan 20. PMID: 28109089

Article Published Date : Aug 06, 2017

Study Type : In Vitro Study

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Substances : Betulinic acid

Diseases : Oral Cancer, Squamous cell carcinoma

Pharmacological Actions : Antiproliferative , Tumor Suppressor Protein p53 Upregulation

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Betulinic acid inhibits hepatitis C virus replication by suppressing the NF-κB- and ERK1/2-mediated COX-2 pathway.Jun 22, 2015

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Pubmed Data : Br J Pharmacol. 2015 Jun 23. Epub 2015 Jun 23. PMID: 26102077

Article Published Date : Jun 22, 2015

Study Type : In Vitro Study

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Substances : Betulinic acid

Diseases : Hepatitis C

Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

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Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors.Mar 14, 2007

Pubmed Data : Biomed Pharmacother. 2016 Dec ;84:1533-1537. Epub 2016 Nov 18. PMID: 27876208

Article Published Date : Nov 30, 2016

Study Type : In Vitro Study

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Substances : Betulinic acid

Diseases : Brain Ischemia, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

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Betulinic acid restores imatinib sensitivity in BCR-ABL1 kinase-independent, imatinib-resistant chronic myeloid leukemia.Jan 12, 2020

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Pubmed Data : Ann N Y Acad Sci. 2020 Jan 13. Epub 2020 Jan 13. PMID: 31930541

Article Published Date : Jan 12, 2020

Study Type : In Vitro Study

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Substances : Betulinic acid

Diseases : Cancers: Drug Resistant, Chronic Myeloid Leukemia

Pharmacological Actions : Chemosensitizer, Chemotherapeutic

Additional Keywords : Chemothapeutic Synergy: Imatinib

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Betulinic acid selectively increases protein degradation and enhances prostate cancer-specific apoptosis.Dec 31, 2012

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Betulinic acid-induced cytotoxicity in human breast tumor cell lines MCF-7 and T47D and its modification by tocopherol.Sep 30, 2014

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Pubmed Data : Cancer Invest. 2014 Oct ;32(8):402-8. Epub 2014 Jul 14. PMID: 25019212

Article Published Date : Sep 30, 2014

Study Type : In Vitro Study

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Substances : Betulinic acid, Vitamin E

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Tumor Suppressor Protein p53 Upregulation

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Pubmed Data : Int J Pharm. 2019 Nov 25 ;571:118751. Epub 2019 Oct 9. PMID: 31605722

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Pubmed Data : J Med Chem. 2007 Aug 23;50(17):4087-95. Epub 2007 Jul 31.PMID:17663539

Article Published Date : Aug 23, 2007

Study Type : In Vitro Study

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Substances : Betulinic acid, Curcumin

Diseases : Coronavirus Infection, Severe Acute Respiratory Syndrome

Pharmacological Actions : Antiviral Agents

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Sorafenib and betulinic acid synergistically induces cell cycle arrest and inhibits clonogenic activity in pancreatic ductal adenocarcinoma cells.Oct 18, 2018

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Pubmed Data : Int J Mol Sci. 2018 Oct 19 ;19(10). Epub 2018 Oct 19. PMID: 30347681

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Pubmed Data : Oncotarget. 2018 Jan 9 ;9(3):3794-3804. Epub 2017 Dec 17. PMID: 29423083

Article Published Date : Jan 08, 2018

Study Type : In Vitro Study

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Substances : Betulinic acid

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor

Additional Keywords : Anti-metastatic, Betulinic acid, Breast Cancer, Matrix metalloproteinase-9 (MMP-9) inhibitor

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This review emphasizes the potential application of some of the well-researched natural compounds that target AR for prevention and therapy of PCa.Jun 27, 2016

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Pubmed Data : Semin Cancer Biol. 2016 Jun 28. Epub 2016 Jun 28. PMID: 27370570

Article Published Date : Jun 27, 2016

Study Type : Review

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Substances : Betulinic acid, Capsaicin, Curcumin, EGCG (Epigallocatechin gallate), Silibinin

Diseases : Prostate Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemopreventive

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View the Evidence: 116 Abstracts with Betulinic acid Research

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Betulinic acid inhibited IL-1β-induced inflammation in osteoarthritis chondrocytes by activating PPAR-γ.Sep 17, 2015

Self-assembled betulinic acid can be used to ameliorate the cytotoxic effects of Doxorubicin.Apr 30, 2015

A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 in liposome systems for lung cancer treatment.Dec 31, 2019

A combination therapy of betulinic acid and fluvastatin that reduces the risk of both rheumatoid arthritis and CVD.Aug 31, 2017

Anti-inflammatory effect and potential mechanism of betulinic acid on λ-carrageenan-induced paw edema in mice.Sep 30, 2019

Antiinflammatory properties of betulinic acid and xylopic acid in the carrageenan-induced pleurisy model of lung inflammation.Feb 28, 2018

BA may be an effective agent for the prevention and treatment of cadmium-induced diseases in humans.Dec 14, 2018

Beneficial effect of betulinic acid on hyperglycemia via suppression of hepatic glucose production.Jan 14, 2014

Betulinic acid alleviates dextran sulfate sodium-induced colitis and visceral pain.Feb 28, 2018

Betulinic acid alleviates endoplasmic reticulum stress-mediated NAFLD.Jan 10, 2019

Betulinic acid alleviates non-alcoholic fatty liver.Apr 30, 2013

Betulinic acid and betulin ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro.Sep 30, 2013

Betulinic acid attenuates dexamethasone-induced oxidative damage.Apr 16, 2018

Betulinic acid attenuates lipopolysaccharide-induced vascular hyporeactivity.Jul 26, 2019

Betulinic acid attenuates T-2-toxin-induced testis oxidative damage.Nov 25, 2019

Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells.Apr 18, 2004

Betulinic acid can be the potential therapeutic agent for virus infection via anti-inflammatory activity.Jun 30, 2015

Betulinic acid chemosensitizes breast cancer cells.May 24, 2018

Betulinic acid could have a role in Alzheimer's disease through protecting microcirculation, alleviating inflammation, and up-regulating BDNF expression.Jan 10, 2018

Betulinic acid derivative BA5 had a potent anti-inflammatory activity on a model of parasite-driven heart disease.Dec 31, 2018

Betulinic acid improves insulin sensitivity, hyperglycemia, inflammation and oxidative stress in metabolic syndrome.Oct 04, 2018

Betulinic acid induces apoptosis and inhibits metastasis of human colorectal cancer cells in vitro and in vivo.Mar 18, 2019

Betulinic acid induces apoptosis and inhibits metastasis of human renal carcinoma cells in vitro and in vivo.Jan 10, 2018

Betulinic acid induces apoptosis and suppresses metastasis in hepatocellular carcinoma cell lines.Dec 31, 2018

Betulinic acid induces apoptosis of gallbladder cancer cells via repressing SCD1.Jan 07, 2020

Betulinic acid inhibits high-fat diet-induced obesity and improves energy balance by activating AMPK.Mar 31, 2019

Betulinic acid pretreatment was able to prevent Alzheimer's disease induced neurobehavioral deficits.Jan 29, 2018

Betulinic acid prevents alcohol-induced liver damage by improving the antioxidant system.Dec 31, 2013

Betulinic acid protects against cerebral ischemia-reperfusion injury.Apr 29, 2011

Betulinic acid protects against cerebral ischemia-reperfusion injury.Sep 30, 2017

Betulinic acid protects the neuronal damage in new born rats from isoflurane-induced apoptosis in the developing brain.Oct 31, 2017

Betulinic acid restores hippocampal cAMP/cGMP and BDNF, improves cerebral blood flow and recovers memory deficits. May 16, 2018

Betulinic acid suppresses breast cancer aerobic glycolysis.Dec 31, 2018

Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress.Apr 12, 2020

Betulinic acid was able to mitigate dexamethasone -induced oxidative stress and might play an important role in repairs of oxidative damage in immunological system.Jun 30, 2015

Effect of betulinic acid and its ionic derivatives on M-MuLV replication.Apr 12, 2018

Protective effect of betulinic acid against intracerebroventricular streptozotocin induced cognitive impairment and neuronal damage.May 31, 2018

Protective effect of betulinic acid on early atherosclerosis.Feb 04, 2017

Protective effect of betulinic acid on Freund's complete adjuvant-induced arthritis in rats.Jul 30, 2019

Protective effects of betulinic acid on intestinal mucosal injury induced by cyclophosphamide in mice.Sep 30, 2019

The antitumor activity of betulinic acid-loaded nanoliposomes against colorectal cancer.Jan 31, 2020

Z. jujuba fruit ethanolic extract possesses antidiarrhoeal and antibacterial activity in a dose depending manner.May 19, 2018

A derivative of betulinic acid may be a viable treatment for lung cancer metastasis, either alone or in combination, without causing damage to normal cells.May 29, 2015

A number of plant polyphenols have chemosensitizing and radiosensitizing activity. Nov 01, 2005

Betulin and betulinic acid can serve as potential anti-infectives in the controlling chronic infection of P. aeruginosa.Mar 07, 2018

Betulinic acid a radiosensitizer in head and neck squamous cell carcinoma cell lines.Feb 28, 2010

Betulinic acid alleviates myocardial hypoxia/reoxygenation injury.Nov 04, 2018

Betulinic acid ameliorates experimental diabetic-induced renal inflammation and fibrosis.Jan 14, 2016

Betulinic Acid and its derivatives could be potential antitumor agents against human ovarian cancer. Jun 01, 2015

Betulinic acid and the pharmacological effects of tumor suppression.Oct 31, 2016

Betulinic acid and ursolic acid have potential use as therapeutic agents against estrogen-dependent tumors.Aug 21, 2014

Betulinic acid appears to be the predominant anti-HIV-1 constituent of Peltophorum africanum.Feb 01, 2009

Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications.Sep 14, 2018

Betulinic acid could be an interesting and safe candidate for the treatment of type 2 diabetes and bone diseases.Jul 17, 2017

Betulinic acid could induce colorectal cancer cell death by inducing apoptosis.Oct 04, 2017

Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells.Sep 30, 2006

Betulinic acid derivatives can protect human Müller cells from glutamate-induced oxidative stress.Jul 21, 2019

Betulinic acid enhances vitamin D3-induced differentiation in human promyelocytic leukemia cells. Jul 01, 2004

Betulinic acid exerts cytotoxic activity against multidrug-resistant tumor cells.Dec 31, 2017

Betulinic acid exerts potent antitumor effects on paclitaxel-resistant human lung carcinoma cells.Aug 31, 2018

Betulinic acid has anti-proliferative effects on canine cancers. Aug 31, 2018

Betulinic acid has apoptotic activity against head and neck squamous cell carcinoma.Aug 31, 2003

Betulinic acid has therapeutic potential in the prevention and treatment of cancer and HIV infection. Jan 01, 2004

Betulinic acid increases radiosensitization of oral squamous cell carcinoma.Sep 30, 2017

Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma.Jun 28, 2010

Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells.Dec 31, 2017

Betulinic acid induces apoptosis in human cervical cancer cells.Nov 30, 2017

Betulinic acid induces apoptosis in human neuroblastoma cell lines.Sep 30, 1997

Betulinic acid induces cell death by necrosis in Trypanosoma cruzi.Sep 30, 2017

Betulinic acid induces DNA damage and apoptosis in SiHa cells.Mar 31, 2018

Betulinic acid induces programmed cell death in human chronic myelogenous leukemia (CML) cells. Mar 15, 2005

Betulinic acid induces ROS-dependent apoptosis and S-Phase arrest in human multiple myeloma.Dec 31, 2018

Betulinic acid

View the Evidence:
116 Abstracts with Betulinic acid Research