Betulinic acid

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20 Diseases Researched for Betulinic acid
NameACCKFocus
Chemotherapy-Induced Toxicity: Doxorubicin15Locked
Inflammation15Locked
Osteoarthritis15Locked
HIV Infections22Locked
Influenza A12Locked
Oxidative Stress12Locked
Prostate Cancer22Locked
Bladder Cancer11Locked
Breast Cancer11Locked
Breast Cancer: estrogen receptor alpha-positive11Locked
Cancers: All11Locked
Cancers: Drug Resistant11Locked
Colon Cancer11Locked
Diabetic Nephropathy11Locked
Hepatitis C11Locked
Leukemia: Chronic myelogenous leukemia (CML) 11Locked
Lung Cancer11Locked
Lung Cancer: Metastatic11Locked
Ovarian Cancer11Locked
Promyelocytic leukemia 11Locked
20 Pharmacological Actions Researched for Betulinic acid
NameACCKFocus
Anti-Inflammatory Agents38Locked
Anti-Apoptotic15Locked
Chemoprotective Agents15Locked
Interleukin-1 beta downregulation15Locked
Apoptotic44Locked
Antiproliferative 33Locked
Antiviral Agents23Locked
Anti-HIV Agents22Locked
Anti-metastatic22Locked
Antioxidants12Locked
Chemopreventive22Locked
Antimutagenic Agents11Locked
Antineoplastic Agents11Locked
Chemosensitizer11Locked
Cyclooxygenase 2 Inhibitors11Locked
Enzyme Inhibitors11Locked
Epidermal growth factor receptor (EGFR) inhibitor11Locked
Estrogen Receptor Modulators11Locked
NF-kappaB Inhibitor11Locked
Radiosensitizer11Locked

View the Evidence:
133 Abstracts with Betulinic acid Research

[+]

Betulinic acid inhibited IL-1β-induced inflammation in osteoarthritis chondrocytes by activating PPAR-γ.Sep 17, 2015

Pubmed Data : Int Immunopharmacol. 2015 Sep 18. Epub 2015 Sep 18. PMID: 26391061
Article Published Date : Sep 17, 2015
Study Type : Human In Vitro
Additional Links
Substances : Betulinic acid
Diseases : Inflammation, Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

Self-assembled betulinic acid can be used to ameliorate the cytotoxic effects of Doxorubicin.Apr 30, 2015

Pubmed Data : Biomed Pharmacother. 2015 May ;72:144-57. Epub 2015 Apr 24. PMID: 26054689
Article Published Date : Apr 30, 2015
Study Type : Human In Vitro
Additional Links
Substances : Betulinic acid
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Anti-Apoptotic, Chemoprotective Agents
[+]

The data presented here provide strong evidence supporting the use of betulinic acid to prevent endothelial dysfunction.Dec 08, 2020

Pubmed Data : J Agric Food Chem. 2020 Dec 9 ;68(49):14523-14530. Epub 2020 Nov 24. PMID: 33232606
Article Published Date : Dec 08, 2020
Study Type : Human In Vitro
Additional Links
Substances : Betulinic acid
Diseases : Atherosclerosis, Endothelial Dysfunction, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 in liposome systems for lung cancer treatment.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nanomedicine (Lond). 2020 Jan ;15(1):41-54. PMID: 31868113
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Betulinic acid, Ginsenosides, Honokiol, Parthenolide
Diseases : Lung Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Natural Substance Synergy
[+]

A combination therapy of betulinic acid and fluvastatin that reduces the risk of both rheumatoid arthritis and CVD.Aug 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Sep ;93:681-694. Epub 2017 Jul 8. PMID: 28692940
Article Published Date : Aug 31, 2017
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Arthritis, Cardiovascular Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Anti-inflammatory effect and potential mechanism of betulinic acid on λ-carrageenan-induced paw edema in mice.Sep 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Oct ;118:109347. Epub 2019 Aug 16. PMID: 31545273
Article Published Date : Sep 30, 2019
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-5 downregulation, Interleukin-6 Downregulation
[+]

Antiinflammatory properties of betulinic acid and xylopic acid in the carrageenan-induced pleurisy model of lung inflammation.Feb 28, 2018

Pubmed Data : Phytother Res. 2018 Mar ;32(3):480-487. Epub 2017 Dec 15. PMID: 29243291
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Lung Inflammation, Pleurisy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

BA may be an effective agent for the prevention and treatment of cadmium-induced diseases in humans.Dec 14, 2018

Pubmed Data : Toxicol Lett. 2018 Dec 15 ;299:56-66. Epub 2018 Sep 16. PMID: 30232032
Article Published Date : Dec 14, 2018
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Cadmium Poisoning
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Cadmium
[+]

Beneficial effect of betulinic acid on hyperglycemia via suppression of hepatic glucose production.Jan 14, 2014

Pubmed Data : J Agric Food Chem. 2014 Jan 15 ;62(2):434-42. Epub 2013 Dec 30. PMID: 24354358
Article Published Date : Jan 14, 2014
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Diabetes Mellitus: Type 2, Hyperglycemia
Pharmacological Actions : Enzyme Inhibitors, Hypoglycemic Agents
[+]

Betulinic acid alleviates dextran sulfate sodium-induced colitis and visceral pain.Feb 28, 2018

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2018 Mar ;391(3):285-297. Epub 2017 Dec 26. PMID: 29279966
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive , Antioxidants
[+]

Betulinic acid alleviates endoplasmic reticulum stress-mediated NAFLD.Jan 10, 2019

Pubmed Data : Br J Pharmacol. 2019 Jan 11. Epub 2019 Jan 11. PMID: 30635917
Article Published Date : Jan 10, 2019
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
[+]

Betulinic acid alleviates non-alcoholic fatty liver.Apr 30, 2013

Pubmed Data : Biochem Pharmacol. 2013 May 1 ;85(9):1330-40. Epub 2013 Feb 19. PMID: 23435355
Article Published Date : Apr 30, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Fatty Liver, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective, Hypolipidemic
[+]

Betulinic acid ameliorates cerebral injury in middle cerebral artery occlusion.Jul 22, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ACS Chem Neurosci. 2021 Jul 23. Epub 2021 Jul 23. PMID: 34296845
Article Published Date : Jul 22, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions : Autophagy Inhibitors, Neuroprotective Agents
[+]

Betulinic acid ameliorates the severity of acute pancreatitis.Jun 25, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2021 Jun 26 ;22(13). Epub 2021 Jun 26. PMID: 34206763
Article Published Date : Jun 25, 2021
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Pancreatitis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Betulinic acid and betulin ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro.Sep 30, 2013

Pubmed Data : Int Immunopharmacol. 2013 Oct ;17(2):184-90. Epub 2013 Jun 28. PMID: 23816536
Article Published Date : Sep 30, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Alcoholic Liver Disease, Fatty Liver
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
[+]

Betulinic acid attenuated bleomycin-induced pulmonary fibrosis by effectively intervening Wnt/β-catenin signaling.Dec 31, 2020

Pubmed Data : Phytomedicine. 2021 Jan ;81:153428. Epub 2020 Dec 1. PMID: 33341025
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents, Wnt/β-catenin signaling pathway modulation
[+]

Betulinic acid attenuates dexamethasone-induced oxidative damage.Apr 16, 2018

Pubmed Data : Biomed Pharmacother. 2018 Apr 17 ;103:499-508. Epub 2018 Apr 17. PMID: 29677535
Article Published Date : Apr 16, 2018
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
Problem Substances : Dexamethasone
[+]

Betulinic acid attenuates lipopolysaccharide-induced vascular hyporeactivity.Jul 26, 2019

Pubmed Data : Inflammopharmacology. 2019 Jul 27. Epub 2019 Jul 27. PMID: 31352642
Article Published Date : Jul 26, 2019
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Sepsis
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation, Vasodilator Agents
[+]

Betulinic acid attenuates T-2-toxin-induced testis oxidative damage.Nov 25, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2019 Nov 26 ;9(12). Epub 2019 Nov 26. PMID: 31779213
Article Published Date : Nov 25, 2019
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants
[+]

Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells.Apr 18, 2004

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Cancer. 2004 Apr 19 ;90(8):1672-8. PMID: 15083202
Article Published Date : Apr 18, 2004
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Cancer Metastasis, Melanoma, Skin Cancer
Pharmacological Actions : Anti-metastatic, Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Betulinic acid can be the potential therapeutic agent for virus infection via anti-inflammatory activity.Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2015 Jul ;23(4):345-9. Epub 2015 Jul 1. PMID: 26157551
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Influenza A
Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents
Additional Keywords : Dose Response
[+]

Betulinic acid chemosensitizes breast cancer cells.May 24, 2018

Pubmed Data : Cell Death Dis. 2018 May 25 ;9(6):636. Epub 2018 May 25. PMID: 29802332
Article Published Date : May 24, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer
[+]

Betulinic acid could have a role in Alzheimer's disease through protecting microcirculation, alleviating inflammation, and up-regulating BDNF expression.Jan 10, 2018

Pubmed Data : Microcirculation. 2018 11 ;25(8):e12503. Epub 2018 Oct 8. PMID: 30178892
Article Published Date : Jan 10, 2018
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Brain-derived neurotrophic factor modulator, Neuroprotective Agents
[+]

Betulinic acid derivative BA5 had a potent anti-inflammatory activity on a model of parasite-driven heart disease.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2019 ;10:1257. Epub 2019 Jun 11. PMID: 31244833
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Chagas Disease, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, Interferon Gamma Reducer, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Betulinic acid improves insulin sensitivity, hyperglycemia, inflammation and oxidative stress in metabolic syndrome.Oct 04, 2018

Pubmed Data : Arch Physiol Biochem. 2018 Oct 5:1-9. Epub 2018 Oct 5. PMID: 30288995
Article Published Date : Oct 04, 2018
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : High Fructose Diet, Metabolic Syndrome X
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Insulin Sensitizers, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Betulinic acid induces apoptosis and inhibits metastasis of human colorectal cancer cells in vitro and in vivo.Mar 18, 2019

Pubmed Data : Bioorg Med Chem. 2019 Mar 19. Epub 2019 Mar 19. PMID: 30910472
Article Published Date : Mar 18, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic
[+]

Betulinic acid induces apoptosis and inhibits metastasis of human renal carcinoma cells in vitro and in vivo.Jan 10, 2018

Pubmed Data : J Cell Biochem. 2018 11 ;119(10):8611-8622. Epub 2018 Jun 20. PMID: 29923216
Article Published Date : Jan 10, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Kidney Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic
[+]

Betulinic acid induces apoptosis and suppresses metastasis in hepatocellular carcinoma cell lines.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2019 Jan ;23(1):586-595. Epub 2018 Nov 12. PMID: 30417527
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic
[+]

Betulinic acid induces apoptosis of gallbladder cancer cells via repressing SCD1.Jan 07, 2020

Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2020 Jan 8. Epub 2020 Jan 8. PMID: 31915810
Article Published Date : Jan 07, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Gallbladder Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Betulinic acid inhibits cell proliferation and migration in gastric cancer.Dec 14, 2020

Pubmed Data : Eur J Pharmacol. 2020 Dec 15 ;889:173493. Epub 2020 Aug 26. PMID: 32860808
Article Published Date : Dec 14, 2020
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Gastric Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , NF-kappaB Inhibitor
[+]

Betulinic acid inhibits high-fat diet-induced obesity and improves energy balance by activating AMPK.Mar 31, 2019

Pubmed Data : Nutr Metab Cardiovasc Dis. 2019 Apr ;29(4):409-420. Epub 2019 Jan 8. PMID: 30799179
Article Published Date : Mar 31, 2019
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Nonalcoholic fatty liver disease (NAFLD), Obesity
Pharmacological Actions : Hepatoprotective
Additional Keywords : Anti-Obesity Agents
[+]

Betulinic acid pretreatment was able to prevent Alzheimer's disease induced neurobehavioral deficits.Jan 29, 2018

Pubmed Data : Behav Brain Res. 2018 Jan 30 ;337:99-106. Epub 2017 Oct 3. PMID: 28986104
Article Published Date : Jan 29, 2018
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Betulinic acid prevents alcohol-induced liver damage by improving the antioxidant system.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Vet Sci. 2014 ;15(1):141-8. Epub 2013 Dec 27. PMID: 24378582
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Alcohol Toxicity , Lipid Peroxidation
Pharmacological Actions : Antioxidants, Hepatoprotective
[+]

Betulinic acid protects against cerebral ischemia-reperfusion injury.Sep 30, 2017

Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2017 Oct ;37(5):744-749. Epub 2017 Oct 20. PMID: 29058289
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Cerebral Ischemia
Pharmacological Actions : Neuroprotective Agents
[+]

Betulinic acid protects against cerebral ischemia-reperfusion injury.Apr 29, 2011

Pubmed Data : Nitric Oxide. 2011 Apr 30 ;24(3):132-8. Epub 2011 Feb 1. PMID: 21292018
Article Published Date : Apr 29, 2011
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Brain: Oxidative Stress, Brain Ischemia
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nitric Oxide Inhibitor
[+]

Betulinic acid protects the neuronal damage in new born rats from isoflurane-induced apoptosis in the developing brain.Oct 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Nov ;95:1631-1635. Epub 2017 Oct 6. PMID: 28950663
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Betulinic acid restores hippocampal cAMP/cGMP and BDNF, improves cerebral blood flow and recovers memory deficits. May 16, 2018

Pubmed Data : Eur J Pharmacol. 2018 May 17 ;832:56-66. Epub 2018 May 17. PMID: 29778746
Article Published Date : May 16, 2018
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Brain Inflammation , Cognitive Decline/Dysfunction, Dementia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Brain-derived neurotrophic factor modulator, Neuroprotective Agents
[+]

Betulinic acid suppresses breast cancer aerobic glycolysis.Dec 31, 2018

Pubmed Data : Biochem Pharmacol. 2019 03 ;161:149-162. Epub 2019 Jan 24. PMID: 30684465
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative
Additional Keywords : Cancer Glycolysis
[+]

Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress.Apr 12, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Biochem Funct. 2020 Apr 13. Epub 2020 Apr 13. PMID: 32283563
Article Published Date : Apr 12, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Gastric Cancer
Pharmacological Actions : Anti-Apoptotic, Anti-metastatic, Antiproliferative
[+]

Betulinic acid was able to mitigate dexamethasone -induced oxidative stress and might play an important role in repairs of oxidative damage in immunological system.Jun 30, 2015

Pubmed Data : Int Immunopharmacol. 2015 Jul ;27(1):85-94. Epub 2015 May 7. PMID: 25959028
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Dose Response
Problem Substances : Dexamethasone
[+]

Effect of betulinic acid and its ionic derivatives on M-MuLV replication.Apr 12, 2018

Pubmed Data : Biochem Biophys Res Commun. 2018 Apr 13. Epub 2018 Apr 13. PMID: 29660337
Article Published Date : Apr 12, 2018
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Murine Leukemia Virus
Pharmacological Actions : Anti-Retroviral Agents
[+]

Protective effect of betulinic acid against intracerebroventricular streptozotocin induced cognitive impairment and neuronal damage.May 31, 2018

Pubmed Data : Pharmacol Rep. 2018 Jun ;70(3):540-548. Epub 2017 Dec 6. PMID: 29674241
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Brain Inflammation , Diabetes: Cognitive Dysfunction, Memory Disorders, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Protective effect of betulinic acid on early atherosclerosis.Feb 04, 2017

Pubmed Data : Eur J Pharmacol. 2017 Feb 5 ;796:224-232. Epub 2016 Nov 26. PMID: 27894808
Article Published Date : Feb 04, 2017
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Atherosclerosis, Diabetic Complications, Endothelial Dysfunction
Pharmacological Actions : Anti-atherogenic, Vasoprotective
[+]

Protective effect of betulinic acid on Freund's complete adjuvant-induced arthritis in rats.Jul 30, 2019

Pubmed Data : J Biochem Mol Toxicol. 2019 Jul 31:e22373. Epub 2019 Jul 31. PMID: 31364231
Article Published Date : Jul 30, 2019
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Protective effects of betulinic acid on intestinal mucosal injury induced by cyclophosphamide in mice.Sep 30, 2019

Pubmed Data : Pharmacol Rep. 2019 Oct ;71(5):929-939. Epub 2019 May 7. PMID: 31450028
Article Published Date : Sep 30, 2019
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Chemoprotective Agents, Gastroprotective
[+]

Synergistic effect of betulinic acid, apigenin and skimmianine (BASk) in high cholesterol diet.May 31, 2021

Pubmed Data : Cytokine. 2021 Jun ;142:155475. Epub 2021 Mar 2. PMID: 33667961
Article Published Date : May 31, 2021
Study Type : Animal Study
Additional Links
Substances : Apigenin, Betulinic acid
Diseases : Atherosclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
Additional Keywords : Natural Substance Synergy
[+]

The antitumor activity of betulinic acid-loaded nanoliposomes against colorectal cancer.Jan 31, 2020

Pubmed Data : J Biomed Nanotechnol. 2020 Feb 1 ;16(2):235-251. PMID: 32252884
Article Published Date : Jan 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Z. jujuba fruit ethanolic extract possesses antidiarrhoeal and antibacterial activity in a dose depending manner.May 19, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Open Access Maced J Med Sci. 2018 May 20 ;6(5):757-766. Epub 2018 May 15. PMID: 29875842
Article Published Date : May 19, 2018
Study Type : Animal Study
Additional Links
Substances : Betulinic acid, Jujube
Diseases : Diarrhea
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Antidiarrheals
Additional Keywords : Dose Response
[+]

A derivative of betulinic acid may be a viable treatment for lung cancer metastasis, either alone or in combination, without causing damage to normal cells.May 29, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 May 30 ;6(15):13671-87. PMID: 25909174
Article Published Date : May 29, 2015
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

A number of plant polyphenols have chemosensitizing and radiosensitizing activity. Nov 01, 2005

Pubmed Data : Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1630-47. PMID: 16356126
Article Published Date : Nov 01, 2005
Study Type : Review
Additional Links
Substances : Betulinic acid, Caffeic acid phenethyl ester, Curcumin, Emodin, Flavonoids, Genistein, Green Tea, Polyphenols, Resveratrol, Silymarin, Ursolic Acid
Diseases : Cancers: Drug Resistant
Pharmacological Actions : Chemosensitizer, Radiosensitizer
[+]

Antidiabetic effects of betulinic acid mediated by the activation of the AMP-activated protein kinase pathway.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2021 ;16(4):e0249109. Epub 2021 Apr 5. PMID: 33819291
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents
[+]

Betulin and betulinic acid can serve as potential anti-infectives in the controlling chronic infection of P. aeruginosa.Mar 07, 2018

Pubmed Data : Microb Pathog. 2018 Mar 8 ;118:48-60. Epub 2018 Mar 8. PMID: 29526565
Article Published Date : Mar 07, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Pseudomonas aeruginosa
Pharmacological Actions : Anti-Infective Agents, Quorum Sensing Inhibition
[+]

Betulinic acid a radiosensitizer in head and neck squamous cell carcinoma cell lines.Feb 28, 2010

Pubmed Data : Strahlenther Onkol. 2010 Mar ;186(3):143-8. Epub 2010 Feb 22. PMID: 20339825
Article Published Date : Feb 28, 2010
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Head and Neck Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Radiosensitizer
[+]

Betulinic acid alleviates myocardial hypoxia/reoxygenation injury.Nov 04, 2018

Pubmed Data : Eur J Pharmacol. 2018 Nov 5 ;838:53-59. Epub 2018 Aug 17. PMID: 30125567
Article Published Date : Nov 04, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Hypoxia, Myocardial Ischemia, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Betulinic acid ameliorates experimental diabetic-induced renal inflammation and fibrosis.Jan 14, 2016

Pubmed Data : Mol Cell Endocrinol. 2016 10 15 ;434:135-43. Epub 2016 Jun 27. PMID: 27364889
Article Published Date : Jan 14, 2016
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor, Renoprotective
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Betulinic Acid and its derivatives could be potential antitumor agents against human ovarian cancer. Jun 01, 2015

Pubmed Data : Med Res Rev. 2015 Jun 2. Epub 2015 Jun 2. PMID: 26032847
Article Published Date : Jun 01, 2015
Study Type : Review
Additional Links
Substances : Betulinic acid
Diseases : Ovarian Cancer
Pharmacological Actions : Chemopreventive
[+]

Betulinic acid and the pharmacological effects of tumor suppression.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2016 Nov ;14(5):4489-4495. Epub 2016 Oct 4. PMID: 27748864
Article Published Date : Oct 31, 2016
Study Type : Review
Additional Links
Substances : Betulinic acid
Diseases : Cancers: All
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

Betulinic acid and ursolic acid have potential use as therapeutic agents against estrogen-dependent tumors.Aug 21, 2014

Pubmed Data : Biochem Biophys Res Commun. 2014 Aug 22 ;451(2):282-7. Epub 2014 Aug 1. PMID: 25088993
Article Published Date : Aug 21, 2014
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid, Prunella vulgaris, Ursolic Acid
Diseases : Breast Cancer, Breast Cancer: estrogen receptor alpha-positive, Prostate Cancer
Pharmacological Actions : Estrogen Receptor Modulators
[+]

Betulinic acid appears to be the predominant anti-HIV-1 constituent of Peltophorum africanum.Feb 01, 2009

Pubmed Data : Tohoku J Exp Med. 2009 Feb;217(2):93-9. PMID: 19212101
Article Published Date : Feb 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid, Peltophorum africanum
Diseases : HIV Infections
Pharmacological Actions : Anti-HIV Agents
Additional Keywords : Plant Extracts
[+]

Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications.Sep 14, 2018

Pubmed Data : Life Sci. 2018 Sep 15 ;209:24-33. Epub 2018 Aug 1. PMID: 30076920
Article Published Date : Sep 14, 2018
Study Type : Review
Additional Links
Substances : Betulinic acid
Diseases : Cancers: All
Pharmacological Actions : Apoptotic
[+]

Betulinic acid could be an interesting and safe candidate for the treatment of type 2 diabetes and bone diseases.Jul 17, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Jul 18 ;7(1):5777. Epub 2017 Jul 18. PMID: 28720829
Article Published Date : Jul 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Osteogenic
[+]

Betulinic acid could induce colorectal cancer cell death by inducing apoptosis.Oct 04, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2017 Oct 5 ;8(10):e3087. Epub 2017 Oct 5. PMID: 28981110
Article Published Date : Oct 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer
[+]

Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells.Sep 30, 2006

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2006 Oct ;374(1):11-20. Epub 2006 Sep 9. PMID: 16964520
Article Published Date : Sep 30, 2006
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Breast Cancer, Colon Cancer, Glioma, Lung Cancer, Neuroblastoma, Rhabdomyosarcoma, Thyroid Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cyclin D1 Down-Regulation
[+]

Betulinic acid derivatives can protect human Müller cells from glutamate-induced oxidative stress.Jul 21, 2019

Pubmed Data : Exp Cell Res. 2019 Jul 22:111509. Epub 2019 Jul 22. PMID: 31344390
Article Published Date : Jul 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Oxidative Stress, Retinal Diseases
Pharmacological Actions : Antioxidants
[+]

Betulinic acid enhances vitamin D3-induced differentiation in human promyelocytic leukemia cells. Jul 01, 2004

Pubmed Data : Anticancer Drugs. 2004 Jul;15(6):619-24. PMID: 15205607
Article Published Date : Jul 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid, Vitamin D
Diseases : Promyelocytic leukemia
Additional Keywords : Natural Substance Synergy
[+]

Betulinic acid exerts cytotoxic activity against multidrug-resistant tumor cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:481. Epub 2018 May 15. PMID: 29867487
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Cancers: All, Cancers: Multi-Drug Resistant
Pharmacological Actions : Antiproliferative , Cytotoxic
[+]

Betulinic acid exerts potent antitumor effects on paclitaxel-resistant human lung carcinoma cells.Aug 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Sep ;16(3):3628-3634. Epub 2018 Jul 6. PMID: 30127971
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Cancers: Drug Resistant, Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Betulinic acid exhibits anti-cancer properties in U937 leukemia cellsDec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anim Cells Syst (Seoul). 2021 ;25(2):119-127. Epub 2021 Apr 23. PMID: 34234893
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Myeloid Leukemia: Acute
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Betulinic acid exhibits antiviral effects against dengue virus infection.Jan 11, 2020

Pubmed Data : Antiviral Res. 2020 12 ;184:104954. Epub 2020 Oct 17. PMID: 33080251
Article Published Date : Jan 11, 2020
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Dengue
Pharmacological Actions : Antiviral Agents
[+]

Betulinic acid has anti-proliferative effects on canine cancers. Aug 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : In Vivo. 2018 Sep-Oct;32(5):1081-1088. PMID: 30150429
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Cancers: Canine
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Betulinic acid has apoptotic activity against head and neck squamous cell carcinoma.Aug 31, 2003

Pubmed Data : Head Neck. 2003 Sep ;25(9):732-40. PMID: 12953308
Article Published Date : Aug 31, 2003
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Head and Neck Cancer, Squamous cell carcinoma
Pharmacological Actions : Apoptotic
[+]

Betulinic acid has therapeutic potential in the prevention and treatment of cancer and HIV infection. Jan 01, 2004

Pubmed Data : Med Res Rev. 2004 Jan;24(1):90-114. PMID: 14595673
Article Published Date : Jan 01, 2004
Study Type : Commentary
Additional Links
Substances : Betulinic acid
Diseases : Cancers: All, HIV Infections
Pharmacological Actions : Anti-HIV Agents, Apoptotic
Additional Keywords : Selective Cytotoxicity
[+]

Betulinic acid increases radiosensitization of oral squamous cell carcinoma.Sep 30, 2017

Pubmed Data : Oncol Rep. 2017 Oct ;38(4):2360-2368. Epub 2017 Aug 3. PMID: 28791404
Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Oral Cancer
Pharmacological Actions : Radiosensitizer
[+]

Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma.Jun 28, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Cancer. 2010 Jun 29 ;103(1):43-51. Epub 2010 Jun 1. PMID: 20517313
Article Published Date : Jun 28, 2010
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Rhabdomyosarcoma
Pharmacological Actions : Apoptotic
[+]

Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells.Dec 31, 2017

Pubmed Data : Ultrastruct Pathol. 2018 Jan-Feb;42(1):49-54. Epub 2017 Dec 1. PMID: 29192840
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic
[+]

Betulinic acid induces apoptosis in human cervical cancer cells.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2017 Dec ;40(6):1669-1678. Epub 2017 Sep 28. PMID: 29039440
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Cervical Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
[+]

Betulinic acid induces apoptosis in human neuroblastoma cell lines.Sep 30, 1997

Pubmed Data : Eur J Cancer. 1997 Oct ;33(12):2007-10. PMID: 9516843
Article Published Date : Sep 30, 1997
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Neuroblastoma
Pharmacological Actions : Apoptotic
[+]

Betulinic acid induces cell death by necrosis in Trypanosoma cruzi.Sep 30, 2017

Pubmed Data : Acta Trop. 2017 Oct ;174:72-75. Epub 2017 Jul 6. PMID: 28690148
Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Trypanosomiasis
Pharmacological Actions : Trypanocidal Agents
[+]

Betulinic acid induces DNA damage and apoptosis in SiHa cells.Mar 31, 2018

Pubmed Data : Mutat Res. 2018 Apr ;828:1-9. Epub 2018 Feb 10. PMID: 29555058
Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest
[+]

Betulinic acid induces programmed cell death in human chronic myelogenous leukemia (CML) cells. Mar 15, 2005

Pubmed Data : Toxicol Lett. 2005 Mar 15;155(3):343-51. PMID: 15649617
Article Published Date : Mar 15, 2005
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic
[+]

Betulinic acid induces ROS-dependent apoptosis and S-Phase arrest in human multiple myeloma.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:5083158. Epub 2019 Jun 9. PMID: 31281581
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Multiple Myeloma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, NF-kappaB Inhibitor
[+]

Betulinic acid Inhibits cell proliferation in human oral squamous cell carcinoma.Aug 06, 2017

Pubmed Data : Oncol Res. 2017 Aug 7 ;25(7):1141-1152. Epub 2017 Jan 20. PMID: 28109089
Article Published Date : Aug 06, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Tumor Suppressor Protein p53 Upregulation
[+]

Betulinic acid inhibits endometriosis through specific suppression of the ERβ signalling pathway.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Endocrinol (Lausanne). 2020 ;11:604648. Epub 2020 Dec 10. PMID: 33362719
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Endometriosis
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-1 (MMP-1) inhibitor
[+]

Betulinic acid inhibits hepatitis C virus replication by suppressing the NF-κB- and ERK1/2-mediated COX-2 pathway.Jun 22, 2015

Pubmed Data : Br J Pharmacol. 2015 Jun 23. Epub 2015 Jun 23. PMID: 26102077
Article Published Date : Jun 22, 2015
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Hepatitis C
Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors.Mar 14, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Res. 2007 Mar 15 ;67(6):2816-23. PMID: 17363604
Article Published Date : Mar 14, 2007
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Prostate Cancer
Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Apoptotic, Vascular Endothelial Growth Factor Inhibitors
[+]

Betulinic acid inhibits pyroptosis in spinal cord injury.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Sci. 2021 ;17(4):1138-1152. Epub 2021 Mar 11. PMID: 33867836
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

Betulinic acid inhibits stemness and EMT of pancreatic cancer cells via activation of AMPK signalingDec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2019 Jan ;54(1):98-110. Epub 2018 Oct 24. PMID: 30365057
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Chemosensitizer
Additional Keywords : Cancer Stem Cells, Chemotherapeutic Synergy: Gemcitabine
[+]

Betulinic acid inhibits the migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.Jan 31, 2019

Pubmed Data : Int Immunopharmacol. 2019 Feb ;67:186-193. Epub 2018 Dec 13. PMID: 30553912
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation
[+]

Betulinic acid is a safe and effective herbal medicine compound that can be used for the prevention of hepatocellular carcinoma growth.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2019 ;11(11):6952-6964. Epub 2019 Nov 15. PMID: 31814899
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Betulinic acid lowers lipid accumulation in adipocytes through enhanced NCoA1-PPARγ interaction.May 23, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Infect Public Health. 2019 May 24. Epub 2019 May 24. PMID: 31133421
Article Published Date : May 23, 2019
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Obesity
Pharmacological Actions : Hypolipidemic
Additional Keywords : Anti-Obesity Agents
[+]

Betulinic acid may offer therapeutic potential towards the treatment of cardiac fibrosis.Oct 31, 2017

Pubmed Data : Mol Med Rep. 2017 Nov ;16(5):6320-6325. Epub 2017 Aug 22. PMID: 28849070
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Betulinic acid may serve as a potential treatment of diabetic nephropathy.Apr 30, 2016

Pubmed Data : Biomed Pharmacother. 2016 May ;80:338-42. Epub 2016 Apr 6. PMID: 27133074
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Diabetic Nephropathy
Pharmacological Actions : Antiproliferative
Additional Keywords : Fibronectin
[+]

Betulinic acid might be a potential therapeutic agent for the treatment of rheumatoid arthritis.Oct 25, 2018

Pubmed Data : J Cell Biochem. 2018 Oct 26. Epub 2018 Oct 26. PMID: 30367550
Article Published Date : Oct 25, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Betulinic acid prevents the acquisition of ciprofloxacin-mediated mutagenesis in Staphylococcus aureus.May 06, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 May 7 ;24(9). Epub 2019 May 7. PMID: 31067626
Article Published Date : May 06, 2019
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Antimutagenic Agents
Problem Substances : Antibiotics
[+]

Betulinic acid promotes TRAIL function on liver cancer progression inhibition through p53/Caspase-3 signaling activation.Mar 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Apr ;88:349-358. Epub 2017 Jan 21. PMID: 28119237
Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Betulinic acid protects against cerebral ischemia/reperfusion injury by activating the PI3K/Akt signaling pathway.Nov 30, 2016

Pubmed Data : Biomed Pharmacother. 2016 Dec ;84:1533-1537. Epub 2016 Nov 18. PMID: 27876208
Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Brain Ischemia, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Betulinic acid protects DOX-triggered cardiomyocyte hypertrophy.Dec 23, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Dec 24 ;26(1). Epub 2020 Dec 24. PMID: 33374365
Article Published Date : Dec 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Cardiac Hypertrophy, Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective, Chemoprotective Agents
[+]

Betulinic acid regulates the proliferation of SGC-7901 cells.Oct 31, 2020

Pubmed Data : Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2020 Nov ;36(6):628-632. PMID: 33719271
Article Published Date : Oct 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation
[+]

Betulinic acid restores imatinib sensitivity in BCR-ABL1 kinase-independent, imatinib-resistant chronic myeloid leukemia.Jan 12, 2020

Pubmed Data : Ann N Y Acad Sci. 2020 Jan 13. Epub 2020 Jan 13. PMID: 31930541
Article Published Date : Jan 12, 2020
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Cancers: Drug Resistant, Chronic Myeloid Leukemia
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Betulinic acid restricts human bladder cancer cell proliferation in vitro.Mar 03, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Mar 4 ;26(5). Epub 2021 Mar 4. PMID: 33806566
Article Published Date : Mar 03, 2021
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Bladder Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

Betulinic acid selectively increases protein degradation and enhances prostate cancer-specific apoptosis.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(2):e56234. Epub 2013 Feb 12. PMID: 23424652
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Selective Cytotoxicity
[+]

Betulinic acid sensitization of low pH adapted human melanoma cells to hyperthermia.Feb 28, 2002

Pubmed Data : Int J Hyperthermia. 2002 Mar-Apr;18(2):153-64. PMID: 11911485
Article Published Date : Feb 28, 2002
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Melanoma
Therapeutic Actions : Heat Therapy
Pharmacological Actions : Apoptotic, Chemosensitizer
[+]

Betulinic acid shows anticancer activity against equine melanoma cells and permeates isolated equine skin in vitro.Feb 04, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Vet Res. 2020 Feb 5 ;16(1):44. Epub 2020 Feb 5. PMID: 32024502
Article Published Date : Feb 04, 2020
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Melanoma
Pharmacological Actions : Antiproliferative
Additional Keywords : Dose Response
[+]

Betulinic acid suppresses breast cancer metastasis by targeting GRP78-mediated glycolysis and ER stress apoptotic pathway.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:8781690. Epub 2019 Aug 19. PMID: 31531187
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic
Additional Keywords : Cancer Glycolysis
[+]

Betulinic acid suppresses ovarian cancer cell proliferation through induction of apoptosis.Jul 02, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2019 Jul 3 ;9(7). Epub 2019 Jul 3. PMID: 31277238
Article Published Date : Jul 02, 2019
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells.Jul 14, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Cancer. 2010 Jul 15 ;127(2):282-92. PMID: 19937797
Article Published Date : Jul 14, 2010
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Multiple Myeloma
Pharmacological Actions : Antiproliferative , Apoptotic, Interleukin-6 Downregulation, STAT3 Inhibitor
[+]

Betulinic acid suppresses Th17 response and ameliorates psoriasis-like murine skin inflammation.Jul 31, 2019

Pubmed Data : Int Immunopharmacol. 2019 Aug ;73:343-352. Epub 2019 May 23. PMID: 31129421
Article Published Date : Jul 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Psoriasis
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory: Th17 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Betulinic acid was able to induce rapid cell death in all colon cancer stem cells.Dec 02, 2015

Pubmed Data : Curr Stem Cell Res Ther. 2015 Dec 3. Epub 2015 Dec 3. PMID: 26647913
Article Published Date : Dec 02, 2015
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Enzyme Inhibitors
Additional Keywords : Cancer Stem Cells
[+]

Betulinic acid was found to have antimutagenic activity in this study. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Genet Mol Res. 2015 ;14(3):9745-52. Epub 2015 Aug 19. PMID: 26345907
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Pharmacological Actions : Antimutagenic Agents
[+]

Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathyDec 31, 2018

Pubmed Data : Pain. 2019 Jan ;160(1):117-135. PMID: 30169422
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Chemotherapy-Induced Toxicity: Paclitaxel, Chemotherapy-Induced Toxicity: Peripheral Neuropathy, HIV Infections
Pharmacological Actions : Neuroprotective Agents
[+]

Betulinic acid-induced apoptosis in leukemia cells.Jul 31, 2004

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Leukemia. 2004 Aug ;18(8):1406-12. PMID: 15201849
Article Published Date : Jul 31, 2004
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Leukemia
Pharmacological Actions : Apoptotic
[+]

Betulinic acid-induced cytotoxicity in human breast tumor cell lines MCF-7 and T47D and its modification by tocopherol.Sep 30, 2014

Pubmed Data : Cancer Invest. 2014 Oct ;32(8):402-8. Epub 2014 Jul 14. PMID: 25019212
Article Published Date : Sep 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid, Vitamin E
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation.Jun 30, 2003

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Cancer Res. 2003 Jul ;9(7):2866-75. PMID: 12855667
Article Published Date : Jun 30, 2003
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Melanoma
Pharmacological Actions : Antioxidants, Apoptotic
[+]

Betulinic acid-mediated apoptosis in human prostate cancer cells involves p53 and NF-κB pathways.Feb 09, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2017 Feb 10 ;22(2). Epub 2017 Feb 10. PMID: 28208611
Article Published Date : Feb 09, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemopreventive, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Betulinic acid-mediated tuning of PERK/CHOP signalling by Sp1 inhibition as a novel therapeutic strategy for glioblastoma.Apr 14, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancers (Basel). 2020 Apr 15 ;12(4). Epub 2020 Apr 15. PMID: 32326583
Article Published Date : Apr 14, 2020
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Glioblastoma
Pharmacological Actions : Chemotherapeutic
[+]

Betulinic acid: a natural product with anticancer activity.Dec 31, 2008

Pubmed Data : Mol Nutr Food Res. 2009 Jan ;53(1):140-6. PMID: 19065582
Article Published Date : Dec 31, 2008
Study Type : Review
Additional Links
Substances : Betulinic acid
Diseases : Cancers: All
Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor
[+]

Combination therapy with low concentrations of sorafenib and betulinic acid had the capacity to induce high levels of cell death.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Sci. 2017 Nov ;108(11):2265-2272. Epub 2017 Sep 19. PMID: 28846180
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Antiproliferative, Apoptotic, Betulinic acid, Carcinoma: Non-Small-Cell Lung, Natural Substance/Drug Synergy
[+]

Curcumin and betulinic acid downregulate epidermal growth factor receptor in bladder cancer cells.May 01, 2010

Pubmed Data : Mol Cancer Res. 2010 May;8(5):739-50. Epub 2010 Apr 20. PMID: 20407012
Article Published Date : May 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid, Curcumin
Diseases : Bladder Cancer
Pharmacological Actions : Antineoplastic Agents, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Doxorubicin combined with betulinic acid or lonidamine in RGD ligand-targeted pH-sensitive micellar system for ovarian cancer treatment.Nov 24, 2019

Pubmed Data : Int J Pharm. 2019 Nov 25 ;571:118751. Epub 2019 Oct 9. PMID: 31605722
Article Published Date : Nov 24, 2019
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Ovarian Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

French Chaga contains betulin and betulinic acid at higher levels than in other Chaga.Jan 31, 2018

Pubmed Data : Integr Cancer Ther. 2018 Feb 1:1534735418757912. Epub 2018 Feb 1. PMID: 29484963
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid, Chaga Mushroom (Inonotus obliquus)
Diseases : Lung Cancer
Pharmacological Actions : Cytotoxic
[+]

Gemcitabine and betulinic acid co-encapsulated PLGA-PEG polymer nanoparticles for improved efficacy of cancer chemotherapy.Apr 30, 2019

Pubmed Data : Mater Sci Eng C Mater Biol Appl. 2019 May ;98:764-771. Epub 2019 Jan 8. PMID: 30813082
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Cancers: All
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Hypoxia increases the apoptotic response to betulinic acid and betulin in human non-small cell lung cancer cells.Jan 04, 2021

Pubmed Data : Chem Biol Interact. 2021 Jan 5 ;333:109320. Epub 2020 Nov 9. PMID: 33181113
Article Published Date : Jan 04, 2021
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
[+]

Inhibitory effects of betulinic acid on LPS-induced neuroinflammation involve M2 microglial polarization.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Mol Neurosci. 2018 ;11:98. Epub 2018 Apr 3. PMID: 29666569
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Mechanism of natural drugs on nonalcoholic fatty liver disease.Apr 04, 2021

Pubmed Data : Mini Rev Med Chem. 2021 Apr 5. Epub 2021 Apr 5. PMID: 33820503
Article Published Date : Apr 04, 2021
Study Type : Review
Additional Links
Substances : Berberine, Betulinic acid, Curcumin, Ginsenosides, Silibinin, Wormwood
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
[+]

Naturally occurring immunomodulators with antitumor activity.Aug 31, 2017

Pubmed Data : Int Immunopharmacol. 2017 Sep ;50:291-304. PMID: 28734166
Article Published Date : Aug 31, 2017
Study Type : Review
Additional Links
Substances : Betulinic acid, Bromelain, Curcumin, Genistein, Resveratrol, Zerumbone
Diseases : Cancers: All
Pharmacological Actions : Antineoplastic Agents, Immunomodulatory
[+]

Paclitaxel-betulinic acid hybrid nanosuspensions for enhanced anti-breast cancer activity.Jan 31, 2019

Pubmed Data : Colloids Surf B Biointerfaces. 2019 Feb 1 ;174:270-279. Epub 2018 Nov 14. PMID: 30469048
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Breast Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Phytocompounds exhibit strong anti-viral activity against SARSsAug 23, 2007

Pubmed Data : J Med Chem. 2007 Aug 23;50(17):4087-95. Epub 2007 Jul 31.PMID:17663539
Article Published Date : Aug 23, 2007
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid, Curcumin
Diseases : Coronavirus Infection, Severe Acute Respiratory Syndrome
Pharmacological Actions : Antiviral Agents
[+]

Sorafenib and betulinic acid synergistically induces cell cycle arrest and inhibits clonogenic activity in pancreatic ductal adenocarcinoma cells.Oct 18, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2018 Oct 19 ;19(10). Epub 2018 Oct 19. PMID: 30347681
Article Published Date : Oct 18, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Pancreatic Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Chemothapeutic Synergy: Sorafenib
[+]

Suppression of HIF-1α accumulation by betulinic acid through proteasome activation in hypoxic cervical cancer.Jan 12, 2020

Pubmed Data : Biochem Biophys Res Commun. 2020 Jan 13. Epub 2020 Jan 13. PMID: 31948750
Article Published Date : Jan 12, 2020
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Cervical Cancer
Pharmacological Actions : Chemotherapeutic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]

Suppression of lncRNA MALAT1 by betulinic acid inhibits hepatocellular carcinoma progression.Sep 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Transl Med. 2020 Oct ;10(6):e190. PMID: 33135336
Article Published Date : Sep 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , MicroRNA modulator
[+]

The present study suggests that betulinic acid has anti-hepatic fibrosis activity.Dec 31, 2018

Pubmed Data : J Nat Med. 2019 Jan ;73(1):179-189. Epub 2018 Oct 30. PMID: 30377904
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Liver Fibrosis
Pharmacological Actions : Autophagy Up-regulation, Hepatoprotective
[+]

These findings suggested that betulinic acid might be a potential agent for inhibiting the growth and metastasis of breast cancer.Jan 08, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2018 Jan 9 ;9(3):3794-3804. Epub 2017 Dec 17. PMID: 29423083
Article Published Date : Jan 08, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Anti-metastatic, Betulinic acid, Breast Cancer, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

This review emphasizes the potential application of some of the well-researched natural compounds that target AR for prevention and therapy of PCa.Jun 27, 2016

Pubmed Data : Semin Cancer Biol. 2016 Jun 28. Epub 2016 Jun 28. PMID: 27370570
Article Published Date : Jun 27, 2016
Study Type : Review
Additional Links
Substances : Betulinic acid, Capsaicin, Curcumin, EGCG (Epigallocatechin gallate), Silibinin
Diseases : Prostate Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemopreventive

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