Black Pepper

Name	AC	CK
Oxidative Stress	18	79
Inflammation	21	67
Diabetes Mellitus: Type 2	7	37
C-Reactive Protein	3	30
Coronavirus Infection	10	30
Depression	8	26
Vitiligo	6	26
Breast Cancer	16	24
Inflammatory Bowel Diseases	3	22
Hypertension	2	20
Smoking Cessation: Nicotine Addiction	2	20
Alzheimer's Disease	12	17
Neurodegenerative Diseases	10	17
Cancers: All	12	15
Lipopolysaccharide-Induced Toxicity	8	15
Multiple Myeloma	1	15
Rheumatoid Arthritis	1	15
Allergic Rhinitis	3	14
Anxiety	3	14
Lung Cancer	7	14
Liver Cancer	7	13
Obesity	7	13
Fibrosis	2	12
High Fat Diet	6	12
Parkinson's Disease	8	12
Stroke: Ischemic	2	12
Adrenaline: Elevated	1	10
Adrenaline: Low	1	10
Allergies	1	10
Catecholamines: Elevated	1	10
Catecholamines: Low	1	10
Cognitive Decline/Dysfunction	4	10
Colorectal Cancer	9	10
Diabetic Retinopathy	1	10
Dysmenorrhea	1	10
Hemodialysis	1	10
Lupus Erythematosus: Cutaneous	1	10
Metabolic Diseases	1	10
Muscle Damage: Exercise-Induced	1	10
Neck Pain	1	10
Nonalcoholic fatty liver disease (NAFLD)	1	10
Osteoarthritis: Knee	1	10
Premenstrual syndrome	1	10
Smoking Cessation	1	10
Stroke: Attenuation/Recovery	1	10
Sympathetic Nervous System Diseases	1	10
Ultraviolet Radiation Induced Damage	2	10
Cadmium Poisoning	3	9
Colon Cancer	7	8
Osteosarcoma	2	8
Candida Albicans	7	7
Cervical Cancer	3	7
Staphylococcus aureus infection	6	7
Brain Inflammation	4	6
Cerebral Ischemia	3	6
Chemically-Induced Liver Damage	3	6
Colitis	3	6
Hyperlipidemia	3	6
Leishmaniasis	3	6
Liver Fibrosis	3	6
Memory Disorders	3	6
Chemotherapy-Induced Toxicity: Doxorubicin	3	5
Insulin Resistance	3	5
Malaria	4	5
Radiation	3	5
Chemotherapy-Induced Toxicity: Cyclophosphamide	2	4
Diabetes: Cognitive Dysfunction	2	4
Diabetic Complications	2	4
Endotoxemia	1	4
Epilepsy	2	4
Escherichia coli Infections	4	4
Gastrointestinal Diseases	2	4
Kidney Damage	2	4
Liver Damage: Drug-Induced	2	4
Malabsorption Syndrome	1	4
Microvilli atrophy	1	4
Sepsis	3	4
Wound Healing	3	4
Arthritis	2	3
Breast Cancer: Triple Negative	3	3
Chronic Pain	1	3
Diarrhea	2	3
Gastritis	2	3
Helicobacter Pylori Infection	2	3
Hepatitis C	1	3
Lung Inflammation	1	3
Myocardial Fibrosis	2	3
Oral Cancer	2	3
Pancreatitis	2	3
Prostate Cancer	3	3
Pseudomonas aeruginosa	3	3
Salmonella Infections	3	3
Smoking	1	3
Squamous cell carcinoma	2	3
Toxoplasma gondii Infection	2	3
Triglycerides: Elevated	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Aging	1	2
Alcohol Toxicity	1	2
Alloxan toxicity	1	2
Aluminum Toxicity	1	2
Amnesia: Drug-Induced	1	2
Anxiety Disorders	1	2
Asthma	1	2
Atopic Dermatitis	1	2
Bacterial Infections	1	2
Bacterial Infections and Mycoses	2	2
Benzo[a]pyrene-induced Toxicity	1	2
Bisphenol Toxicity	1	2
Bladder Cancer	1	2
Brain Injury: Traumatic	1	2
Brain: Oxidative Stress	1	2
Breast Cancer: Chemically-Induced	1	2
Cataract	1	2
Chemobrain	1	2
Chronic Myeloid Leukemia	2	2
Copper Toxicity	1	2
DNA damage	1	2
Depressive Disorder	1	2
Diabetes Mellitus: Type 1	1	2
Encephalomyelitis	1	2
Encephalopathy	1	2
Endometritis	1	2
Epilepsy: Drug-Induced	1	2
Fat Malabsorption	1	2
Food Allergies	1	2
Gallstones	1	2
Gastric Cancer	2	2
Gastric Ulcer	1	2
HPA Axis Dysregulation	1	2
Heavy Metal Toxicity	1	2
Hepatic Steatosis	1	2
High Cholesterol	1	2
Huntington Disease	2	2
Hyperglycemia	1	2
Hyperthyroidism	1	2
Hypothyroidism	1	2
IgE-Mediated Hypersensitivity	1	2
Indigestion: Fats	1	2
Ischemia	1	2
Klebsiella Infections	2	2
Lead Poisoning	1	2
Leptin Resistance	1	2
Lichen Planus	1	2
Liver Cancer: Prevention	1	2
Liver Damage	1	2
Low Immune Function: Natural Killer Cells	1	2
Lung Damage	1	2
Lupus Nephritis	1	2
Lupus-Like Syndrome	1	2
Mastitis	1	2
Melanoma	1	2
Metabolic Syndrome X	1	2
Multiple Sclerosis	1	2
Myelotoxicity	1	2
Myocardial Ischemia	1	2
Nephropathy	1	2
Ovarian Cancer	2	2
Periodontitis	1	2
Pesticide Toxicity	1	2
Pyelonephritis	1	2
Sciatica	1	2
Sleep Disorders	1	2
Steatorrhea	1	2
Stress	1	2
Stroke	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Thyroid Diseases	1	2
Toxoplasmosis	1	2
Tumors	2	2
Advanced Glycation End products (AGE)	1	1
Aflatoxicosis	1	1
Aspergillosis	1	1
Atherosclerosis	1	1
Autism	1	1
Autoimmune Diseases	1	1
Bacillus Cereus infection	1	1
Bronchitis	1	1
Cancer Stem Cells	1	1
Cancers: Drug Resistant	1	1
Cancers: Radiation-Resistant	1	1
Candida Glabrata	1	1
Cardiovascular Diseases	1	1
Chemotherapy and Radiation Toxicity	1	1
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	1
Cholangiocarcinoma	1	1
Cholera	1	1
Coronary Artery Disease	1	1
Coronavirus Disease (Covid-19)	1	1
Coxsackievirus Infections	1	1
Dental Implantation	1	1
Drug-Induced Toxicity: Gastrointestinal	1	1
Drug-Induced Toxicity: Indomethacin	1	1
Foodborne Pathogens: Prevention/Food Preservation	1	1
Glioblastoma	1	1
Glioblastoma Multiforme	1	1
Glioma	1	1
Head and Neck Cancer	1	1
Infection: Antibiotic Resistant	1	1
Influenza	1	1
Listeria Infections	1	1
Liver Injury: Ischemia/reperfusion	1	1
Methicillin-resistant Staphylococcus aureus	1	1
Micrococcus luteus infections	1	1
Myocardial Infarction	1	1
Organ Transplantation	1	1
Osteoclastoma	1	1
Polycystic Ovary Syndrome	1	1
Psoriasis	1	1
Respiratory Infections	1	1
Rhinovirus Infection	1	1
Seizures	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Steroid-Induced Toxicity	1	1
Systemic Lupus Erythematosus	1	1
Thyroid Cancer	1	1
Traumatic Brain Injury	1	1
Alopecia: Androgenic	1	0

Name	AC	CK
Anti-Inflammatory Agents	69	190
Antioxidants	57	165
Neuroprotective Agents	45	89
Antiproliferative	42	69
Apoptotic	33	48
Tumor Necrosis Factor (TNF) Alpha Inhibitor	19	43
Interleukin-1 beta downregulation	14	37
Interleukin-6 Downregulation	14	35
Gastrointestinal Agents	6	34
NF-kappaB Inhibitor	13	34
Antidepressive Agents	9	28
Hepatoprotective	11	28
Hypoglycemic Agents	7	28
Hypolipidemic	7	28
Cell cycle arrest	11	21
Anti-metastatic	12	18
Cardioprotective	11	18
Cyclooxygenase 2 Inhibitors	4	18
Anti-Apoptotic	10	17
Chemosensitizer	10	17
Immunomodulatory	11	17
Anti-Anxiety Agents	4	16
Anti-Fibrotic	4	15
Anticarcinogenic Agents	9	15
Chemopreventive	11	15
Chemotherapeutic	8	15
Antiviral Agents	10	14
Superoxide Dismutase Up-regulation	3	13
Analgesics	2	12
Anti-Bacterial Agents	12	12
Nrf2 activation	7	12
Postaglandin PGE2 downregulation	2	11
Adiponectin upregulation	1	10
Appetite Suppresant	1	10
Bcl-2 protein down-regulation	2	10
Chemoprotective Agents	6	10
Photoprotective	2	10
Gastroprotective	5	9
Matrix metalloproteinase-9 (MMP-9) inhibitor	4	9
Matrix metalloproteinase-2 (MMP-2) inhibitor	3	8
MicroRNA modulator	4	7
Tumor Suppressor Protein p53 Upregulation	2	7
Anticonvulsants	3	6
Antimicrobial	5	6
Leishmanicidal	3	6
Renoprotective	3	6
Acetylcholinesterase Inhibitor	3	5
Angiogenesis Inhibitors	4	5
Antimalarials	4	5
Bax/Bcl2 ratio: Increase	1	5
Caspase-3 Activation	1	5
Caspase-9 Activation	1	5
Pancreato Protective Agents	3	5
Radioprotective	3	5
Anticholesteremic Agents	2	4
Antifungal Agents	4	4
Antispasmodic	2	4
Heme oxygenase-1 up-regulation	2	4
Immunostimulatory	1	4
Insecticides	1	4
Prophylactic Agents	2	4
Serotonergic	1	4
Transforming growth factor beta (TGF-β) inhibitor	3	4
Antimutagenic Agents	2	3
Antineoplastic Agents	2	3
Antinoceceptive	1	3
Antiparasitic Agents	2	3
Cytotoxic	1	3
Interleukin-10 upregulation	2	3
Multidrug Resistance Gene Modulators	3	3
Vascular Endothelial Growth Factor Inhibitors	2	3
Alpha-amylase inhibitor	1	2
Alpha-glucosidase inhibitor	1	2
Anti-pyretic	1	2
Antidiarrheals	1	2
Antihypertensive Agents	1	2
Antiprotozoal Agents	1	2
Anxiolytic	1	2
Autophagy Inhibitors	1	2
Brain-derived neurotrophic factor modulator	1	2
Detoxifier	1	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Genoprotective	1	2
Immunomodulatory: Th17 downregulation	1	2
Immunosuppressive Agents	1	2
Insecticidal	1	2
Interleukin-4 downregulation	1	2
Interleukin-8 downregulation	2	2
Monoamine Oxidase Inhibitors	1	2
Neuritogenic	1	2
Radiosensitizer	2	2
STAT3 Inhibitor	1	2
Wnt/β-catenin signaling pathway modulation	2	2
Anti-Glycation Agents	1	1
Anti-atherogenic	1	1
Anti-fungal effects	1	1
Autophagy Up-regulation	1	1
Cyclooxygenase 1 Inhibitor	1	1
Cyclooxygenase Inhibitors	1	1
Endocannabinoid Modulator	1	1
Heme oxygenase-1 inducer	1	1
Insulin Sensitizers	1	1
Nitric Oxide Inhibitor	1	1
Prostaglandin PGE2 downregulation	1	1
STAT3 Activation	1	1
Survivin Down-Regulation	1	1
Tumor Necrosis Factor (TNF) Alpha Enhancer	1	1
Wnt/β-catenin pathway down-regulation	1	1

[+]

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Funct. 2018 May 23 ;9(5):2774-2786. PMID: 29691526

Article Published Date : May 22, 2018

Study Type : Human Study

Additional Links

Substances : Black Pepper

Pharmacological Actions : Appetite Suppresant

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Curcumin and piperine supplementation before and after exercise can attenuate some, but not all, aspects of muscle damage.Feb 28, 2017

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Curcuminoid-piperine combination improves radical scavenging activity in women with premenstrual syndrome and dysmenorrhea.Apr 30, 2024

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Pubmed Data : J Altern Complement Med. 2013 Aug ;19(8):709-13. Epub 2013 Mar 28. PMID: 23536963

Article Published Date : Jul 31, 2013

Study Type : Human Study

Additional Links

Substances : Angelica, Black Pepper

Diseases : Smoking Cessation: Nicotine Addiction

Therapeutic Actions : Aromatherapy

Additional Keywords : Natural Substance Synergy

[+]

Evaluation of efficacy of curcumin along with lycopene and piperine in the management of oral submucous fibrosis.Jun 30, 2019

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Antioxidative effects of piperine against cadmium-induced oxidative stress.Oct 08, 2018

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Pubmed Data : J Diet Suppl. 2018 Oct 9:1-12. Epub 2018 Oct 9. PMID: 30299203

Article Published Date : Oct 08, 2018

Study Type : Human In Vitro

Additional Links

Substances : Piperine

Diseases : Cadmium Poisoning

Pharmacological Actions : Antioxidants

Problem Substances : Cadmium

[+]

Curcumin, piperine and taurine combination enhances the efficacy of transarterial chemoembolization therapy.Apr 30, 2024

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Pubmed Data : Behav Brain Funct. 2015 ;11:13. Epub 2015 Mar 29. PMID: 25880991

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Black Pepper

Diseases : Alzheimer's Disease, Anxiety Disorders, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Anxiolytic, Neuroprotective Agents

Additional Keywords : Plant Extracts

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A plant extract of Piper nigrum L. fruits ameliorates amyloid beta(1-42)-induced spatial memory impairment by attenuation of the oxidative stress in the rat hippocampus.Mar 31, 2014

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Pubmed Data : Cell Mol Neurobiol. 2014 Apr ;34(3):437-49. Epub 2014 Jan 19. PMID: 24442916

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Pubmed Data : Cutan Ocul Toxicol. 2019 Mar 1:1-8. Epub 2019 Mar 1. PMID: 30678496

Article Published Date : Feb 28, 2019

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Cataract

Pharmacological Actions : Antioxidants

[+]

Anxiolytic and antidepressant-like effects of essential oil from the fruits of Piper nigrum.Mar 31, 2021

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Pubmed Data : Heliyon. 2021 Apr ;7(4):e06884. Epub 2021 Apr 25. PMID: 33997409

Article Published Date : Mar 31, 2021

Study Type : Animal Study

Additional Links

Substances : Black Pepper

Diseases : Anxiety, Depression

Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents

[+]

Augmentation of hepatoprotective potential of Aegle marmelos in combination with piperine.Aug 19, 2018

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Pubmed Data : Chem Cent J. 2018 Aug 20 ;12(1):94. Epub 2018 Aug 20. PMID: 30123925

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Pubmed Data : Pak J Biol Sci. 2008 Jun 1;11(11):1492-6. PMID: 18817253

Pubmed Data : Curr Pharm Biotechnol. 2016;17(11):962-73. PMID: 27396401

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Pubmed Data : Toxicol Mech Methods. 2008 Jan;18(9):691-6. PMID: 20020926

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : DNA damage, Myelotoxicity

Pharmacological Actions : Genoprotective

Additional Keywords : Natural Substance Synergy

[+]

Cumin and black pepper prevent chemically-induced rat colon carcinogenesis.Jan 01, 2006

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Pubmed Data : J Med Food. 2006;9(2):237-45. PMID: 16822210

Article Published Date : Jan 01, 2006

Study Type : Animal Study

Additional Links

Substances : Black Pepper, Cumin

Diseases : Colon Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

[+]

Curcumin (from Turmeric) in combination with Piperine may attenuate stress-induced depression. Oct 25, 2008

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Pubmed Data : Neurotox Res. 2019 Oct 25. Epub 2019 Oct 25. PMID: 31654381

Article Published Date : Oct 24, 2019

Study Type : Animal Study

Additional Links

Substances : Piperine, Quercetin

Diseases : Parkinson's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

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Pubmed Data : Pharmaceutics. 2022 Aug 26 ;14(9). Epub 2022 Aug 26. PMID: 36145547

Article Published Date : Aug 25, 2022

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Piperine attenuated cardiac fibrosis in mice.Mar 31, 2017

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Pubmed Data : Brain Res. 2012 Dec 7 ;1488:38-50. Epub 2012 Oct 23. PMID: 23099054

Article Published Date : Dec 06, 2012

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Cognitive Decline/Dysfunction, Oxidative Stress, Stress

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Increased Bioavailability, Natural Substance Synergy

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Piperine enhanced the neuroprotective effect of curcumin against LPS-induced neurobehavioral and neurochemical deficits.May 31, 2016

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Pubmed Data : J Cardiovasc Pharmacol. 2008 Nov;52(5):452-458. PMID: 19033825

Article Published Date : Nov 01, 2008

Study Type : Animal Study

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Substances : Piperine

Pharmacological Actions : Antihypertensive Agents

[+]

Piperine has anticonvulsant effects in-vivo and in-vitro.Sep 02, 2015

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Pubmed Data : Channels (Austin). 2015 Sep 3 ;9(5):317-23. PMID: 26542628

Article Published Date : Sep 02, 2015

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Epilepsy

Pharmacological Actions : Anticonvulsants

[+]

Piperine has protective effects on lead acetate induced-nephrotoxicity in rats.Oct 31, 2017

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Pubmed Data : Iran J Basic Med Sci. 2017 Nov ;20(11):1227-1231. PMID: 29299200

Article Published Date : Oct 31, 2017

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Kidney Damage, Lead Poisoning

Pharmacological Actions : Renoprotective

[+]

Piperine has the potential to be used as a bio-enhancing agent in combination with metformin.Dec 31, 2015

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Pubmed Data : Pharmacognosy Res. 2016 Jan-Mar;8(1):56-60. PMID: 26941537

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Bioenhancer, Medication Reduction, Natural Substance Synergy

[+]

Additional Keywords : Dose Response

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[+]

Piperine pretreatment attenuates renal ischemia-reperfusion induced liver injury.Jul 31, 2019

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Pubmed Data : Chin J Nat Med. 2021 Jun ;19(6):412-421. PMID: 34092292

Article Published Date : May 31, 2021

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Inflammation, Sciatica

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-1 beta downregulation, MicroRNA modulator, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Piperine's mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle.Nov 14, 2016

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Protective effects of piperine on ethanol-induced gastric mucosa injury by oxidative stress inhibition.Nov 09, 2022

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Pubmed Data : Ann Med. 2021 Dec ;53(1):2009-2017. PMID: 34751064

Article Published Date : Nov 30, 2021

Study Type : Animal Study

Additional Links

Substances : Piperine, Ursolic Acid

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Additional Keywords : Natural Substance Synergy

[+]

Synergistic effects of curcumin and piperine in cocrystal form: a breakthrough in bladder cancer therapy.Apr 23, 2025

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Pubmed Data : J Biomater Sci Polym Ed. 2025 Apr 24:1-28. Epub 2025 Apr 24. PMID: 40270345

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Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 6. Epub 2011 Apr 6. PMID: 21477634

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Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:1915-1923. Epub 2018 Nov 26. PMID: 30551446

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Black Pepper

Diseases : Allergic Rhinitis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Immunomodulatory: Th17 downregulation, STAT3 Inhibitor

[+]

These results suggest that piperine free P. nigrum extracts can enhance breast cancer cell response to phytochemicals.May 03, 2016

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Pubmed Data : J Ethnopharmacol. 2016 May 4. Epub 2016 May 4. PMID: 27155135

Article Published Date : May 03, 2016

Pubmed Data : J Complement Integr Med. 2016 Jun 25. Epub 2016 Jun 25. PMID: 27343476

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Pubmed Data : J Pharm Sci. 2024 Jul 14. Epub 2024 Jul 14. PMID: 39004416

Article Published Date : Jul 13, 2024

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Candida Albicans, Candida Glabrata

Pharmacological Actions : Antifungal Agents, Antimicrobial

[+]

Antifungal efficacy of spice extracts against Candida albicans.Sep 30, 2019

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Pubmed Data : Indian J Community Med. 2019 Oct ;44(Suppl 1):S77-S80. PMID: 31728098

Article Published Date : Sep 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Bay leaf, Black Pepper, Cinnamon, Cumin

Diseases : Candida Albicans

Pharmacological Actions : Antifungal Agents

[+]

Antimicrobial and synergistic effects of commercial piperine and piperlongumine in combination with conventional antimicrobials.May 03, 2019

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Pubmed Data : Antibiotics (Basel). 2019 May 4 ;8(2). Epub 2019 May 4. PMID: 31060239

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Pubmed Data : Front Pharmacol. 2023 ;14:1145666. Epub 2023 Apr 26. PMID: 37180710

Article Published Date : Dec 31, 2022

Study Type : In Vitro Study

Additional Links

Substances : Cannabinoids , Curcumin, Piperine

Diseases : Colon Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

Additional Keywords : Natural Substance Synergy

[+]

Capsaicin and piperine can overcome multidrug resistance in cancer cells to doxorubicin.Mar 01, 2018

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Pubmed Data : Molecules. 2018 Mar 2 ;23(3). Epub 2018 Mar 2. PMID: 29498663

Article Published Date : Mar 01, 2018

Study Type : In Vitro Study

Additional Links

Substances : Capsaicin, Piperine

Diseases : Cancers: All

Pharmacological Actions : Chemosensitizer, Multidrug Resistance Gene Modulators

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

[+]

Chemoprevention of prostate cancer by natural agents: evidence from molecular and epidemiological studies.Sep 30, 2019

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Pubmed Data : Anticancer Res. 2019 Oct ;39(10):5231-5259. PMID: 31570421

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Pubmed Data : Front Aging Neurosci. 2019 ;11:206. Epub 2019 Aug 27. PMID: 31507403

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Pubmed Data : J Herb Med. 2021 Aug 5:100501. Epub 2021 Aug 5. PMID: 34377631

Article Published Date : Aug 04, 2021

Study Type : Review

Additional Links

Substances : Aloe Vera, Ashwagandha, Black Pepper, Broccoli, Cinnamon, Ginger, Holy Basil, Licorice, Moringa oleifera, Neem, Turmeric

Diseases : Coronavirus Infection

Pharmacological Actions : Immunomodulatory

[+]

Herbal-based nano systems have promising proficiency in treatment of neurodegenerative disorders.Dec 31, 2019

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Pubmed Data : Comput Biol Med. 2021 Aug 28 ;137:104818. Epub 2021 Aug 28. PMID: 34481181

Article Published Date : Aug 27, 2021

Study Type : In Vitro Study

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Substances : Curcumin, Piperine

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

[+]

In this review, they have summarized the recent progress on dietary nutraceuticals in reversing multidrug resistance.Dec 31, 2014

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Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(16):6831-9. PMID: 26514453

Article Published Date : Dec 31, 2014

Study Type : Review

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Substances : beta-Carotene, Bitter Melon, Capsaicin, Curcumin, EGCG (Epigallocatechin gallate), Fruit: All, Fucoxanthin , Gingerol , Grape Seed Extract, Indole-3-Carbinol, Piperine, Quercetin, Resveratrol, Vegetables: All

Diseases : Cancers: All

Pharmacological Actions : Multidrug Resistance Gene Modulators

Additional Keywords : Multidrug Resistance, Natural Substance/Drug Synergy

[+]

In vitro anti-parasitic effect of the alkaloids harmaline and piperine on Toxoplasma gondii.Dec 31, 2023

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Pubmed Data : Phytomedicine. 2018 Sep 28 ;54:98-108. Epub 2018 Sep 28. PMID: 30668388

Article Published Date : Sep 27, 2018

Study Type : In Vitro Study

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Substances : Piperine, Silymarin

Additional Keywords : Food Bioavailability Enhancers

[+]

Piperine exhibits potential antibiofilm activity against Pseudomonas aeruginosa.Dec 28, 2022

Piperine increases pentagamavunon-1 anti-cancer activity on 4T1 breast cancer.Nov 30, 2022

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Pubmed Data : Iran J Pharm Res. 2022 Dec ;21(1):e123820. Epub 2022 Feb 4. PMID: 35765510

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Pubmed Data : Fungal Genet Biol. 2017 Aug 19. Epub 2017 Aug 19. PMID: 28830793

Article Published Date : Aug 18, 2017

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Aspergillosis

Pharmacological Actions : Antioxidants

Problem Substances : Aflatoxin

[+]

Piperine inhibits cell proliferation and induces apoptosis of human gastric cancer cells.Dec 30, 2020

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Pubmed Data : Mol Carcinog. 2014 May 13. Epub 2014 May 13. PMID: 24819444

Article Published Date : May 12, 2014

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Selective Cytotoxicity

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Effects of curcuminoids plus piperine co-supplementation on liver enzymes and inflammation in adults.Jun 30, 2025

The effects of curcumin plus piperine co-administration on inflammation and oxidative stress.Mar 28, 2024

Cancer stem cells as a prognostic biomarker and therapeutic target using curcumin/ piperine extract for multiple myeloma.Sep 30, 2022

Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients.Dec 31, 2022

A standardized Withania somniferra root extract with piperine alleviates the symptoms of anxiety and depression.Oct 24, 2023

An essential oil cream made from marjoram, black pepper, lavender, peppermint developed in this study can be used to improve neck pain.Sep 30, 2014

Black pepper-based beverage induced appetite-suppressing effects.May 22, 2018

Curcumin and piperine supplementation before and after exercise can attenuate some, but not all, aspects of muscle damage.Feb 28, 2017

Curcumin appears to be a complementary treatment option for COVID-19 patients.Dec 31, 2022

Curcumin plus piperine improve body composition in patients with inflammatory bowel disease.Feb 10, 2025

Curcumin-piperine is effective in improving oxidative stress and reducing creatinine in diabetic retinopathy.Dec 31, 2023

Curcumin-piperine might synergise with vitamin D to induce clinical remission in patients with systemic lupus erythematosus.Jan 30, 2024

Curcumin-piperine supplementation can improve serum CRP, triglycerides, and glucose concentrations in patients with T2DM and hypertriglyceridemia.Oct 31, 2024

Curcumin-piperine supplementation over a short period had beneficial effects on some inflammatory and laboratory indices in critically ill patients with sepsis.Jun 13, 2025

Curcuminoid-piperine combination improves radical scavenging activity in women with premenstrual syndrome and dysmenorrhea.Apr 30, 2024

Curcuminoids plus piperine modulate adipokines in type 2 diabetes mellitus.Jan 02, 2018

Effect of curcumin plus Piperine on redox imbalance, fecal calprotectin and cytokine levels in inflammatory bowel disease patients.Jun 27, 2024

Essential oils of black pepper and angelica reduced the level of nicotine craving and allowed a longer delay before next use of tobacco.Jul 31, 2013

Evaluation of efficacy of curcumin along with lycopene and piperine in the management of oral submucous fibrosis.Jun 30, 2019

Fragrance inhalation of patchouli and rose oil reduce sympathetic nervous system activity by 40%; rose oil reduces adrenaline concentrations by 30%. Nov 01, 2002

Herbal formulation turmeric extract, black pepper, and ginger versus naproxen for chronic knee osteoarthritis.Jul 31, 2020

Inhalation of vapor from black pepper reduces smoking withdrawal symptoms.Feb 01, 1994

Oral curcumin with piperine as adjuvant therapy for the treatment of COVID-19.Dec 31, 2020

Prebiotic potential of culinary spices used to support digestion and bioabsorption.Dec 31, 2018

Short term supplementation with curcuminoid and piperine combination significantly improves oxidative and inflammatory status in patients with MetS.Jan 06, 2015

Simultaneous use of narrowband ultraviolet B and topical piperine has a remarkable effect on treatment of vitiligo.May 20, 2018

The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke.Dec 10, 2023

The result of the study demonstrates that NSO 250 mg with 2.5 mg piperine is an effective and well-tolerated supplement for the management of AR symptoms.Aug 08, 2024

The use of piperine-added Curcuma longa L. was effective in the glycaemic and TG control of patients with type 2 diabetes.Feb 13, 2021

This study found that an olfactory stimulus led to improvement of balance ability in the stroke patients.Dec 31, 2014

This study suggested beneficial effects of combined curcuminoids and piperine supplementation on disease severity in patients with NAFLD.Aug 31, 2019

Turmeric supplementation with piperine is more effective than turmeric alone in attenuating oxidative stress and inflammation in hemodialysis.Nov 19, 2022

Vitiligo treated with combined piperine-based topical treatment and narrowband ultraviolet B therapyFeb 24, 2024

Antioxidative effects of piperine against cadmium-induced oxidative stress.Oct 08, 2018

Curcumin, piperine and taurine combination enhances the efficacy of transarterial chemoembolization therapy.Apr 30, 2024

Piperine attenuates UV-R induced cell damage in human keratinocytes.Jun 30, 2017

Piperine attenuates UV-R induced cell damage in human keratinocytes.Jun 30, 2017

Piperine enhanced mitomycin-C therapy in human cervical cancer cells.Nov 19, 2017

Piperine inhibits the proliferation of human osteosarcoma cells via G2/M phase arrest and prevents metastasis.Dec 31, 2014

Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

Alpha-mangostin, piperine and beta-sitosterol as hepatitis C antivirus.Aug 31, 2023

Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain.Oct 22, 2022

Formulation of piperine nanoparticles: in vitro breast cancer cell line and in vivo evaluation.Mar 25, 2022

Herbal supplement (Combi-5) in the management of COVID 19 individual with mild to moderate symptoms: a case report.May 06, 2021

Piperine attenuates cigarette smoke-induced oxidative stress, lung inflammation, and epithelial-mesenchymal transition.Nov 24, 2022

Piperine improves the sensitivity of osteosarcoma cells to doxorubicin.Mar 08, 2023

Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase.Jun 30, 2020

Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination.Jul 14, 2020

Prophylactic effect of resveratrol and piperine on pristane-induced murine model of lupus-like disease.May 31, 2020

A combination of curcumin with piperine exhibited profound cardioprotection compared to curcumin alone-treated group.Dec 31, 2016

A combination of nutrients improves cognitive functioning while decreasing Alzheimer disease neuropathology in an animal model.Jan 01, 2010

A combination of piperine and ferulic acid might be an alternative therapy in the treatment of psychiatric disorders with high efficacy and low side effects.Jul 29, 2015

A methanolic extract of Piper nigrum ameliorates beta-amyloid (1–42)-induced anxiety and depression by attenuation of the oxidative stress in the rat amygdala.Dec 31, 2014

A plant extract of Piper nigrum L. fruits ameliorates amyloid beta(1-42)-induced spatial memory impairment by attenuation of the oxidative stress in the rat hippocampus.Mar 31, 2014

A standardized black pepper seed extract containing β-caryophyllene improves cognitive function in scopolamine-induced amnesia mode.Nov 30, 2021

A traditionally used herbal combination could potentially use as a treatment of cognitive impairment induced by thyroid hormone deficiency.Jul 20, 2020

An extract of curcuma longa showed a 98.6% and 99.2% inhibition of the growth of toxoplasma tachyzoites in 100mg and 200mg doses.Apr 30, 2009

Anti-diarrheal effect of piperine possibly through the interaction with inflammation inducing enzymes.Feb 14, 2024

Antidepressant, anxiolytic, antipyretic, and thrombolytic profiling of methanol extract of the aerial part of Piper nigrum.Jan 31, 2021

Antioxidant effects of piperine in in-vivo cataract model induced by steroids.Feb 28, 2019

Anxiolytic and antidepressant-like effects of essential oil from the fruits of Piper nigrum.Mar 31, 2021

Augmentation of hepatoprotective potential of Aegle marmelos in combination with piperine.Aug 19, 2018

Black pepper and cardamom have immunomodulatory and anti-cancer Apr 01, 2010

Black pepper and Vinca rosea protect against alloxan induced diabetes.Jan 01, 2005

Black pepper extract has therapeutic potential for treating allergic asthma through inhibiting Th2/Th17 responses and mast cells activation.Nov 30, 2017

Black pepper has antispasmodic properties.Jun 01, 2008

Black pepper is a potential inducer of detoxification, indicating its role as a chemopreventive in chemical carcinogenesis.Aug 16, 1993

Black pepper may have a therapeutic role in the treatment of gastrointestinal disorders.Dec 01, 2009

Black Pepper reduces high-fat diet induced oxidative stress.Jan 01, 2004

Black pepper shows potential as a larvicide for the control of certain malaria vector species.Dec 31, 2015

Black pepper significantly improved memory in aluminum chloride induced neurotoxicity mouse model.Dec 31, 2015

Both in vivo and in vitro results confirm the efficacy of black pepper, ginger and thyme extracts extracts as natural antimicrobials and suggests the possibility of using them in treatment procedures.Sep 30, 2014

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344 Abstracts with Black Pepper Research