Black Pepper

Name	AC	CK
Oxidative Stress	10	29
Smoking Cessation: Nicotine Addiction	2	20
Diabetes Mellitus: Type 2	5	17
Vitiligo	5	16
Inflammation	9	13
Lung Cancer	5	12
Adrenaline: Elevated	1	10
Adrenaline: Low	1	10
Catecholamines: Elevated	1	10
Catecholamines: Low	1	10
Depression	4	10
Hypertension	1	10
Metabolic Diseases	1	10
Muscle Damage: Exercise-Induced	1	10
Neck Pain	1	10
Smoking Cessation	1	10
Stroke: Attenuation/Recovery	1	10
Sympathetic Nervous System Diseases	1	10
Ultraviolet Radiation Induced Damage	2	10
Alzheimer's Disease	5	9
Breast Cancer	6	9
Cadmium Poisoning	3	9
Cancers: All	7	9
High Fat Diet	4	8
Lipopolysaccharide-Induced Toxicity	4	8
Neurodegenerative Diseases	3	7
Cognitive Decline/Dysfunction	2	6
Hyperlipidemia	3	6
Obesity	3	6
Staphylococcus aureus infection	5	6
Brain Inflammation	3	5
Cervical Cancer	1	5
Colon Cancer	4	5
Leishmaniasis	2	5
Osteosarcoma	1	5
Parkinson's Disease	3	5
Cerebral Ischemia	2	4
Diabetes: Cognitive Dysfunction	2	4
Endotoxemia	1	4
Gastrointestinal Diseases	2	4
Liver Cancer	2	4
Malabsorption Syndrome	1	4
Microvilli atrophy	1	4
Escherichia coli Infections	3	3
Helicobacter Pylori Infection	2	3
Triglycerides: Elevated	2	3
Allergic Rhinitis	1	2
Alloxan toxicity	1	2
Aluminum Toxicity	1	2
Anxiety Disorders	1	2
Asthma	1	2
Bacterial Infections	1	2
Bacterial Infections and Mycoses	2	2
Benzo[a]pyrene-induced Toxicity	1	2
Breast Cancer: Chemically-Induced	1	2
Cataract	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Colorectal Cancer	2	2
Copper Toxicity	1	2
DNA damage	1	2
Depressive Disorder	1	2
Diabetes Mellitus: Type 1	1	2
Diabetic Complications	1	2
Endometritis	1	2
Epilepsy	1	2
Epilepsy: Drug-Induced	1	2
Fat Malabsorption	1	2
Gallstones	1	2
Gastritis	1	2
HPA Axis Dysregulation	1	2
Heavy Metal Toxicity	1	2
High Cholesterol	1	2
Hyperthyroidism	1	2
Indigestion: Fats	1	2
Inflammatory Bowel Diseases	1	2
Insulin Resistance	1	2
Kidney Damage	1	2
Lead Poisoning	1	2
Leptin Resistance	1	2
Lichen Planus	1	2
Liver Cancer: Prevention	1	2
Liver Fibrosis	1	2
Low Immune Function: Natural Killer Cells	1	2
Lupus Nephritis	1	2
Memory Disorders	1	2
Metabolic Syndrome X	1	2
Myelotoxicity	1	2
Myocardial Fibrosis	1	2
Periodontitis	1	2
Pyelonephritis	1	2
Sepsis	2	2
Steatorrhea	1	2
Stress	1	2
Thyroid Diseases	1	2
Toxoplasma gondii Infection	1	2
Toxoplasmosis	1	2
Tumors	2	2
Aspergillosis	1	1
Atherosclerosis	1	1
Autism	1	1
Autoimmune Diseases	1	1
Bacillus Cereus infection	1	1
Breast Cancer: Triple Negative	1	1
Cancer Stem Cells	1	1
Cancers: Radiation-Resistant	1	1
Candida Albicans	1	1
Dental Implantation	1	1
Foodborne Pathogens: Prevention/Food Preservation	1	1
Klebsiella Infections	1	1
Listeria Infections	1	1
Malaria	1	1
Micrococcus luteus infections	1	1
Oral Cancer	1	1
Organ Transplantation	1	1
Osteoclastoma	1	1
Ovarian Cancer	1	1
Pancreatitis	1	1
Prostate Cancer	1	1
Pseudomonas aeruginosa	1	1
Salmonella Infections	1	1
Squamous cell carcinoma	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Thyroid Cancer	1	1
Wound Healing	1	1
Alopecia: Androgenic	1	0

Name	AC	CK
Antioxidants	26	57
Anti-Inflammatory Agents	24	49
Neuroprotective Agents	20	40
Antiproliferative	20	29
Apoptotic	16	28
Cell cycle arrest	5	14
Analgesics	2	12
Anticarcinogenic Agents	7	12
Antidepressive Agents	5	12
Chemopreventive	7	11
Adiponectin upregulation	1	10
Appetite Suppresant	1	10
Bcl-2 protein down-regulation	2	10
Photoprotective	2	10
Anti-metastatic	4	9
Tumor Necrosis Factor (TNF) Alpha Inhibitor	6	9
Cardioprotective	4	8
Matrix metalloproteinase-2 (MMP-2) inhibitor	3	8
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	8
NF-kappaB Inhibitor	6	8
Tumor Suppressor Protein p53 Upregulation	2	7
Anti-Apoptotic	4	6
Chemosensitizer	2	6
Immunomodulatory	4	6
Interleukin-1 beta downregulation	4	6
Antimicrobial	4	5
Bax/Bcl2 ratio: Increase	1	5
Caspase-3 Activation	1	5
Caspase-9 Activation	1	5
Hypoglycemic Agents	3	5
Interleukin-6 Downregulation	3	5
Leishmanicidal	2	5
Angiogenesis Inhibitors	3	4
Anticholesteremic Agents	2	4
Anticonvulsants	2	4
Antispasmodic	2	4
Hepatoprotective	2	4
Immunostimulatory	1	4
Insecticides	1	4
Serotonergic	1	4
Anti-Bacterial Agents	3	3
Antineoplastic Agents	2	3
Chemotherapeutic	2	3
Hypolipidemic	2	3
Vascular Endothelial Growth Factor Inhibitors	2	3
Acetylcholinesterase Inhibitor	1	2
Anti-Fibrotic	1	2
Antihypertensive Agents	1	2
Antimutagenic Agents	1	2
Antiparasitic Agents	1	2
Antiprotozoal Agents	1	2
Anxiolytic	1	2
Chemoprotective Agents	1	2
Cyclooxygenase 2 Inhibitors	2	2
Detoxifier	1	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Gastroprotective	1	2
Genoprotective	1	2
Immunomodulatory: Th17 downregulation	1	2
Insecticidal	1	2
Monoamine Oxidase Inhibitors	1	2
Multidrug Resistance Gene Modulators	2	2
Nrf2 activation	2	2
Renoprotective	1	2
STAT3 Inhibitor	1	2
Anti-atherogenic	1	1
Antimalarials	1	1
Cyclooxygenase 1 Inhibitor	1	1
Cyclooxygenase Inhibitors	1	1
Endocannabinoid Modulator	1	1
Heme oxygenase-1 inducer	1	1
Interleukin-8 downregulation	1	1
MicroRNA modulator	1	1
Nitric Oxide Inhibitor	1	1
Pancreato Protective Agents	1	1
Prostaglandin PGE2 downregulation	1	1
Radiosensitizer	1	1
Wnt/β-catenin pathway down-regulation	1	1

[+]

An essential oil cream made from marjoram, black pepper, lavender, peppermint developed in this study can be used to improve neck pain.Sep 30, 2014

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Pubmed Data : J Altern Complement Med. 2014 Oct ;20(10):771-9. Epub 2014 Sep 5. PMID: 25192562

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Pubmed Data : J Cell Biochem. 2019 Sep ;120(9):15989-15996. Epub 2019 Jun 6. PMID: 31168845

Article Published Date : Aug 31, 2019

Study Type : Human Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective, Hypolipidemic

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Antioxidative effects of piperine against cadmium-induced oxidative stress.Oct 08, 2018

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Pubmed Data : J Diet Suppl. 2018 Oct 9:1-12. Epub 2018 Oct 9. PMID: 30299203

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Pubmed Data : Int Immunopharmacol. 2015 Jan ;24(1):50-8. Epub 2014 Nov 20. PMID: 25479727

Article Published Date : Dec 31, 2014

Study Type : Human In Vitro

Additional Links

Substances : Piperine

Diseases : Osteosarcoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Cell cycle arrest, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

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Pubmed Data : Tumour Biol. 2014 Apr ;35(4):3305-10. Epub 2013 Nov 24. PMID: 24272201

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Pubmed Data : Cutan Ocul Toxicol. 2019 Mar 1:1-8. Epub 2019 Mar 1. PMID: 30678496

Article Published Date : Feb 28, 2019

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Cataract

Pharmacological Actions : Antioxidants

[+]

Augmentation of hepatoprotective potential of Aegle marmelos in combination with piperine.Aug 19, 2018

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Pubmed Data : Chem Cent J. 2018 Aug 20 ;12(1):94. Epub 2018 Aug 20. PMID: 30123925

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Pubmed Data : Pak J Biol Sci. 2008 Jun 1;11(11):1492-6. PMID: 18817253

Pubmed Data : Curr Pharm Biotechnol. 2016;17(11):962-73. PMID: 27396401

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Pubmed Data : Toxicol Mech Methods. 2008 Jan;18(9):691-6. PMID: 20020926

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : DNA damage, Myelotoxicity

Pharmacological Actions : Genoprotective

Additional Keywords : Natural Substance Synergy

[+]

Cumin and black pepper prevent chemically-induced rat colon carcinogenesis.Jan 01, 2006

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Pubmed Data : J Med Food. 2006;9(2):237-45. PMID: 16822210

Article Published Date : Jan 01, 2006

Study Type : Animal Study

Additional Links

Substances : Black Pepper, Cumin

Diseases : Colon Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

[+]

Curcumin (from Turmeric) in combination with Piperine may attenuate stress-induced depression. Oct 25, 2008

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2013 ;8(11):e81252. Epub 2013 Nov 19. PMID: 24260564

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine, White Pepper

Diseases : High Fat Diet, Inflammation, Obesity

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

Additional Keywords : Dietary Concentrations, Increased Bioavailability, Plant Extracts

[+]

Problem Substances : Aluminum Chloride

[+]

Piperine alleviates doxorubicin-induced cardiotoxicity.Dec 31, 2018

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Pubmed Data : Brain Res. 2012 Dec 7 ;1488:38-50. Epub 2012 Oct 23. PMID: 23099054

Article Published Date : Dec 06, 2012

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Cognitive Decline/Dysfunction, Oxidative Stress, Stress

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Increased Bioavailability, Natural Substance Synergy

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Piperine enhanced the neuroprotective effect of curcumin against LPS-induced neurobehavioral and neurochemical deficits.May 31, 2016

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Pubmed Data : Inflammation. 2016 Jun ;39(3):1025-38. PMID: 26970969

Article Published Date : May 31, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Neuroprotective Agents

[+]

Piperine enhances the antioxidant and anti-Inflammatory activities of thymoquinone against microcystin-LR-induced hepatotoxicity and neurotoxicity.Dec 31, 2018

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Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:1309175. Epub 2019 Apr 16. PMID: 31178949

Article Published Date : Dec 31, 2018

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Pubmed Data : J Cardiovasc Pharmacol. 2008 Nov;52(5):452-458. PMID: 19033825

Article Published Date : Nov 01, 2008

Study Type : Animal Study

Additional Links

Substances : Piperine

Pharmacological Actions : Antihypertensive Agents

[+]

Piperine has anticonvulsant effects in-vivo and in-vitro.Sep 02, 2015

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Pubmed Data : Channels (Austin). 2015 Sep 3 ;9(5):317-23. PMID: 26542628

Article Published Date : Sep 02, 2015

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Epilepsy

Pharmacological Actions : Anticonvulsants

[+]

Piperine has protective effects on lead acetate induced-nephrotoxicity in rats.Oct 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2017 Nov ;20(11):1227-1231. PMID: 29299200

Article Published Date : Oct 31, 2017

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Kidney Damage, Lead Poisoning

Pharmacological Actions : Renoprotective

[+]

Piperine has the potential to be used as a bio-enhancing agent in combination with metformin.Dec 31, 2015

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Pubmed Data : Pharmacognosy Res. 2016 Jan-Mar;8(1):56-60. PMID: 26941537

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Bioenhancer, Medication Reduction, Natural Substance Synergy

[+]

[+]

Piperine pretreatment attenuates renal ischemia-reperfusion induced liver injury.Jul 31, 2019

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Pubmed Data : J Nutr Biochem. 2020 Jan ;75:108261. Epub 2019 Oct 27. PMID: 31710934

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

[+]

Piperine restores streptozotocin-induced cognitive impairments.Jan 29, 2018

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Pubmed Data : Behav Brain Res. 2018 Jan 30 ;337:131-138. Epub 2017 Sep 20. PMID: 28939403

Article Published Date : Jan 29, 2018

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Diabetes: Cognitive Dysfunction, Diabetic Complications

[+]

Piperine supplementation markedly protects erythrocytes from oxidative stress by improving the antioxidant status in high fat fed antithyroid drug treated rats.Nov 01, 2006

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Pubmed Data : Cell Biochem Funct. 2006 Nov-Dec;24(6):491-8. PMID: 16927417

Article Published Date : Nov 01, 2006

Study Type : Animal Study

Additional Links

Substances : Black Pepper, Piperidines

Diseases : Hyperlipidemia, Hyperthyroidism, Thyroid Diseases

Pharmacological Actions : Antioxidants

Additional Keywords : Antithyroid Drugs

[+]

Piperine's mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle.Nov 14, 2016

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Pubmed Data : Exp Ther Med. 2017 Feb ;13(2):695-700. Epub 2016 Dec 27. PMID: 28352353

Article Published Date : Jan 31, 2017

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Epilepsy: Drug-Induced

Pharmacological Actions : Anticonvulsants, Antioxidants

[+]

The antidepressant-like effect of piperine involves the serotonergic system. Apr 06, 2011

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Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 6. Epub 2011 Apr 6. PMID: 21477634

Pubmed Data : J Complement Integr Med. 2016 Jun 25. Epub 2016 Jun 25. PMID: 27343476

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Pubmed Data : J Pharm Pharmacol. 2019 Jul ;71(7):1162-1171. Epub 2019 May 3. PMID: 31049982

Article Published Date : Jun 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Black Pepper

Diseases : Cancers: All, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Apoptotic

[+]

Antifungal efficacy of spice extracts against Candida albicans.Sep 30, 2019

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Pubmed Data : Indian J Community Med. 2019 Oct ;44(Suppl 1):S77-S80. PMID: 31728098

Article Published Date : Sep 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Bay leaf, Black Pepper, Cinnamon, Cumin

Diseases : Candida Albicans

Pharmacological Actions : Antifungal Agents

[+]

Antimicrobial and synergistic effects of commercial piperine and piperlongumine in combination with conventional antimicrobials.May 03, 2019

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Pubmed Data : Antibiotics (Basel). 2019 May 4 ;8(2). Epub 2019 May 4. PMID: 31060239

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Pubmed Data : Molecules. 2018 Mar 2 ;23(3). Epub 2018 Mar 2. PMID: 29498663

Article Published Date : Mar 01, 2018

Study Type : In Vitro Study

Additional Links

Substances : Capsaicin, Piperine

Diseases : Cancers: All

Pharmacological Actions : Chemosensitizer, Multidrug Resistance Gene Modulators

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

[+]

Chemoprevention of prostate cancer by natural agents: evidence from molecular and epidemiological studies.Sep 30, 2019

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Pubmed Data : Anticancer Res. 2019 Oct ;39(10):5231-5259. PMID: 31570421

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Pubmed Data : Chem Biol Interact. 2019 Mar 29. Epub 2019 Mar 29. PMID: 30935902

Article Published Date : Mar 28, 2019

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Piperine, Vitamin E

Diseases : Thyroid Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Herbal-based nano systems have promising proficiency in treatment of neurodegenerative disorders.Dec 31, 2019

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Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(16):6831-9. PMID: 26514453

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Substances : beta-Carotene, Bitter Melon, Capsaicin, Curcumin, EGCG (Epigallocatechin gallate), Fruit: All, Fucoxanthin , Gingerol , Grape Seed Extract, Indole-3-Carbinol, Piperine, Quercetin, Resveratrol, Vegetables: All

Diseases : Cancers: All

Pharmacological Actions : Multidrug Resistance Gene Modulators

Additional Keywords : Multidrug Resistance, Natural Substance/Drug Synergy

[+]

Additional Keywords : Plant Extracts

[+]

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:947-954. Epub 2018 Apr 24. PMID: 29710511

Article Published Date : Jun 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator, NF-kappaB Inhibitor

[+]

Piperine and phenylamide acted synergistically on the leishmania amazonensis parasites.Nov 30, 2011

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Pubmed Data : Sci Rep. 2016 Dec 20 ;6:39239. Epub 2016 Dec 20. PMID: 27995955

Article Published Date : Dec 19, 2016

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Antiproliferative, Apoptotic, lung cancer, Piperine

[+]

Piperine may become a potential therapeutic agent against bacterial sepsis.Dec 31, 2015

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Pubmed Data : Front Pharmacol. 2016 ;7:390. Epub 2016 Oct 20. PMID: 27812336

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Pubmed Data : Sci Pharm. 2017 Jul 3 ;85(3). Epub 2017 Jul 3. PMID: 28671634

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Pubmed Data : Int J Mol Sci. 2020 Jul 24 ;21(15). Epub 2020 Jul 24. PMID: 32721999

Article Published Date : Jul 23, 2020

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Piperine, Resveratrol

Diseases : Breast Cancer

Pharmacological Actions : Chemotherapeutic

[+]

The influence of piperine on the radioprotective effect of curcumin in irradiated human lymphocytes.Aug 31, 2019

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Pubmed Data : Turk J Pharm Sci. 2019 Sep ;16(3):366-370. Epub 2019 Jul 10. PMID: 32454737

Article Published Date : Aug 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Radiation

Pharmacological Actions : Radioprotective

Additional Keywords : Natural Substance Synergy

[+]

The present study provides useful insight into the apoptotic potential of piperine.Dec 31, 2018

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Pubmed Data : Int J Mol Sci. 2015 ;16(7):15727-42. Epub 2015 Jul 10. PMID: 26184171

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View the Evidence: 204 Abstracts with Black Pepper Research

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An essential oil cream made from marjoram, black pepper, lavender, peppermint developed in this study can be used to improve neck pain.Sep 30, 2014

Black pepper-based beverage induced appetite-suppressing effects.May 22, 2018

Curcumin and piperine supplementation before and after exercise can attenuate some, but not all, aspects of muscle damage.Feb 28, 2017

Curcuminoids plus piperine modulate adipokines in type 2 diabetes mellitus.Jan 02, 2018

Essential oils of black pepper and angelica reduced the level of nicotine craving and allowed a longer delay before next use of tobacco.Jul 31, 2013

Evaluation of efficacy of curcumin along with lycopene and piperine in the management of oral submucous fibrosis.Jun 30, 2019

Fragrance inhalation of patchouli and rose oil reduce sympathetic nervous system activity by 40%; rose oil reduces adrenaline concentrations by 30%. Nov 01, 2002

Herbal formulation turmeric extract, black pepper, and ginger versus naproxen for chronic knee osteoarthritis.Jul 31, 2020

Inhalation of vapor from black pepper reduces smoking withdrawal symptoms.Feb 01, 1994

Prebiotic potential of culinary spices used to support digestion and bioabsorption.Dec 31, 2018

Short term supplementation with curcuminoid and piperine combination significantly improves oxidative and inflammatory status in patients with MetS.Jan 06, 2015

Simultaneous use of narrowband ultraviolet B and topical piperine has a remarkable effect on treatment of vitiligo.May 20, 2018

This study found that an olfactory stimulus led to improvement of balance ability in the stroke patients.Dec 31, 2014

This study suggested beneficial effects of combined curcuminoids and piperine supplementation on disease severity in patients with NAFLD.Aug 31, 2019

Antioxidative effects of piperine against cadmium-induced oxidative stress.Oct 08, 2018

Piperine attenuates UV-R induced cell damage in human keratinocytes.Jun 30, 2017

Piperine attenuates UV-R induced cell damage in human keratinocytes.Jun 30, 2017

Piperine enhanced mitomycin-C therapy in human cervical cancer cells.Nov 19, 2017

Piperine inhibits the proliferation of human osteosarcoma cells via G2/M phase arrest and prevents metastasis.Dec 31, 2014

Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase.Jun 30, 2020

Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination.Jul 14, 2020

Prophylactic effect of resveratrol and piperine on pristane-induced murine model of lupus-like disease.May 31, 2020

A combination of curcumin with piperine exhibited profound cardioprotection compared to curcumin alone-treated group.Dec 31, 2016

A combination of nutrients improves cognitive functioning while decreasing Alzheimer disease neuropathology in an animal model.Jan 01, 2010

A combination of piperine and ferulic acid might be an alternative therapy in the treatment of psychiatric disorders with high efficacy and low side effects.Jul 29, 2015

A methanolic extract of Piper nigrum ameliorates beta-amyloid (1–42)-induced anxiety and depression by attenuation of the oxidative stress in the rat amygdala.Dec 31, 2014

A plant extract of Piper nigrum L. fruits ameliorates amyloid beta(1-42)-induced spatial memory impairment by attenuation of the oxidative stress in the rat hippocampus.Mar 31, 2014

A traditionally used herbal combination could potentially use as a treatment of cognitive impairment induced by thyroid hormone deficiency.Jul 20, 2020

An extract of curcuma longa showed a 98.6% and 99.2% inhibition of the growth of toxoplasma tachyzoites in 100mg and 200mg doses.Apr 30, 2009

Antioxidant effects of piperine in in-vivo cataract model induced by steroids.Feb 28, 2019

Augmentation of hepatoprotective potential of Aegle marmelos in combination with piperine.Aug 19, 2018

Black pepper and cardamom have immunomodulatory and anti-cancer Apr 01, 2010

Black pepper and Vinca rosea protect against alloxan induced diabetes.Jan 01, 2005

Black pepper extract has therapeutic potential for treating allergic asthma through inhibiting Th2/Th17 responses and mast cells activation.Nov 30, 2017

Black pepper has antispasmodic properties.Jun 01, 2008

Black pepper is a potential inducer of detoxification, indicating its role as a chemopreventive in chemical carcinogenesis.Aug 16, 1993

Black pepper may have a therapeutic role in the treatment of gastrointestinal disorders.Dec 01, 2009

Black Pepper reduces high-fat diet induced oxidative stress.Jan 01, 2004

Black pepper shows potential as a larvicide for the control of certain malaria vector species.Dec 31, 2015

Black pepper significantly improved memory in aluminum chloride induced neurotoxicity mouse model.Dec 31, 2015

Both in vivo and in vitro results confirm the efficacy of black pepper, ginger and thyme extracts extracts as natural antimicrobials and suggests the possibility of using them in treatment procedures.Sep 30, 2014

Co-administration of curcumin and piperine may provide a useful natural adjuvant in the antidepressant therapy.Dec 31, 2012

Co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression.Jun 30, 2014

Cucumin and piperine in combination have a potent antigenotoxic effect as compared to either agent alone in DMBA-induced genotoxicity in golden Syrian hamsters.Jan 01, 2008

Cumin and black pepper prevent chemically-induced rat colon carcinogenesis.Jan 01, 2006

Curcumin (from Turmeric) in combination with Piperine may attenuate stress-induced depression. Oct 25, 2008

Curcumin and piperine afforded a better neuroprotective effect compared to each of them alone.Nov 15, 2016

Curcumin and piperine showed strong antioxidant and protective effect against QA-induced behavioural and neurological alteration.Jan 29, 2016

Curcumin and piperine-loaded emulsomes as combinational treatment approach enhance the anticancer activity of curcumin on HCT116 colorectal cancer model.Dec 31, 2019

Curcumin can prevent the formation of cholesterol gallstones induced by high fat diet in mice.Dec 31, 2014

Curcumin in combination with piperine shows better suppression of DENA-induced hepatocellular carcinoma in contrast to curcumin on its own. Jul 25, 2015

Curcumin, capsaicin and piperine have anti-inflammatory effects on H. pylori-induced gastritis in gerbils and may have potential chemoprevention of H. pylori-associated gastric carcinogenesis.Jul 02, 2015

Dichloromethane extraction from Piper nigrum L. and P. longum L. to mitigate ischemic stroke.Aug 07, 2020

Dietary ginger and other spice compounds enhance fat digestion and absorption in high-fat fed situation through enhanced secretion of bile salts and a stimulation of the activity pancreatic lipase.Sep 13, 2011

Dietary spices have a beneficial effect on intestinal villi by increasing the absorptive surface of the small intestine, providing for an increased bioavailability of micronutrients.Feb 24, 2010

Neuroprotective Effect of Dichloromethane Extraction From Piper nigrum L. and Piper longum L.Feb 28, 2019

Neuroprotective effect of quercetin in combination with piperine against rotenone-and iron supplement-induced Parkinson's disease.Oct 24, 2019

New insights in vitiligo treatments using bioactive compounds from Piper nigrum.Jan 31, 2019

Oral administration of Curcuma longa associated with white pepper at doses that can be extrapolated to human exposure upon supplementation improves pro-inflammatory disorders.Dec 31, 2012

P. nigrum is a source of potent and safe antileishmanial compounds.Dec 31, 2014

Piper nigrum extract had a low toxicity and a potent anti-tumor effect on mammary tumorigenesis in rats.Oct 27, 2015

Piper Nigrum extract improves OVA-induced nasal epithelial barrier dysfunction via activating Nrf2/HO-1 signaling.Dec 29, 2019

Piper nigrum L possesses potent analgesic and anti-inflammatory activities.Aug 31, 2014

Piper nigrum significantly improved learning and memory deficits associated with aluminium chloride and also showed the anticholinesterase activity with prevention of nerve degeneration.Mar 31, 2015

Piperine alleviates doxorubicin-induced cardiotoxicity.Dec 31, 2018

Piperine ameliorated lupus nephritis by targeting AMPK-mediated activation of NLRP3 inflammasome.Nov 30, 2018

Piperine ameliorated the progression of TNBS-induced colitis.Dec 12, 2019

Piperine ameliorates trimellitic anhydride-induced atopic dermatitis-like symptoms.May 06, 2020

Piperine and Curcumin (from Turmeric) attenuates Cadmium induced immunotoxicity.Dec 01, 2008

Piperine as a neuroprotective functional component in rats with cerebral ischemic injury.Oct 31, 2019

Piperine attenuated cardiac fibrosis in mice.Mar 31, 2017

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View the Evidence:
204 Abstracts with Black Pepper Research