Black Pepper

Name	AC	CK
Oxidative Stress	10	29
Diabetes Mellitus: Type 2	6	27
Smoking Cessation: Nicotine Addiction	2	20
Vitiligo	5	16
Inflammation	11	15
Alzheimer's Disease	9	14
Lung Cancer	6	13
Fibrosis	2	12
Cancers: All	9	11
Adrenaline: Elevated	1	10
Adrenaline: Low	1	10
Breast Cancer	7	10
Catecholamines: Elevated	1	10
Catecholamines: Low	1	10
Cognitive Decline/Dysfunction	4	10
Depression	4	10
High Fat Diet	5	10
Hypertension	1	10
Lipopolysaccharide-Induced Toxicity	5	10
Metabolic Diseases	1	10
Muscle Damage: Exercise-Induced	1	10
Neck Pain	1	10
Nonalcoholic fatty liver disease (NAFLD)	1	10
Osteoarthritis: Knee	1	10
Smoking Cessation	1	10
Stroke: Attenuation/Recovery	1	10
Sympathetic Nervous System Diseases	1	10
Ultraviolet Radiation Induced Damage	2	10
Cadmium Poisoning	3	9
Neurodegenerative Diseases	4	8
Obesity	4	8
Parkinson's Disease	5	8
Cerebral Ischemia	3	6
Cervical Cancer	2	6
Colon Cancer	5	6
Colorectal Cancer	5	6
Coronavirus Infection	4	6
Hyperlipidemia	3	6
Liver Cancer	4	6
Staphylococcus aureus infection	5	6
Brain Inflammation	3	5
Leishmaniasis	2	5
Osteosarcoma	1	5
Allergic Rhinitis	2	4
Candida Albicans	4	4
Diabetes: Cognitive Dysfunction	2	4
Endotoxemia	1	4
Epilepsy	2	4
Gastrointestinal Diseases	2	4
Kidney Damage	2	4
Malabsorption Syndrome	1	4
Memory Disorders	2	4
Microvilli atrophy	1	4
Breast Cancer: Triple Negative	3	3
Escherichia coli Infections	3	3
Helicobacter Pylori Infection	2	3
Myocardial Fibrosis	2	3
Pancreatitis	2	3
Triglycerides: Elevated	2	3
Alloxan toxicity	1	2
Aluminum Toxicity	1	2
Anxiety Disorders	1	2
Asthma	1	2
Atopic Dermatitis	1	2
Bacterial Infections	1	2
Bacterial Infections and Mycoses	2	2
Benzo[a]pyrene-induced Toxicity	1	2
Breast Cancer: Chemically-Induced	1	2
Cataract	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Chronic Myeloid Leukemia	2	2
Colitis	1	2
Copper Toxicity	1	2
DNA damage	1	2
Depressive Disorder	1	2
Diabetes Mellitus: Type 1	1	2
Diabetic Complications	1	2
Encephalomyelitis	1	2
Endometritis	1	2
Epilepsy: Drug-Induced	1	2
Fat Malabsorption	1	2
Gallstones	1	2
Gastritis	1	2
HPA Axis Dysregulation	1	2
Heavy Metal Toxicity	1	2
High Cholesterol	1	2
Hyperglycemia	1	2
Hyperthyroidism	1	2
Hypothyroidism	1	2
Indigestion: Fats	1	2
Inflammatory Bowel Diseases	1	2
Insulin Resistance	1	2
Ischemia	1	2
Lead Poisoning	1	2
Leptin Resistance	1	2
Lichen Planus	1	2
Liver Cancer: Prevention	1	2
Liver Damage	1	2
Liver Fibrosis	1	2
Low Immune Function: Natural Killer Cells	1	2
Lupus Nephritis	1	2
Lupus-Like Syndrome	1	2
Mastitis	1	2
Metabolic Syndrome X	1	2
Multiple Sclerosis	1	2
Myelotoxicity	1	2
Myocardial Ischemia	1	2
Ovarian Cancer	2	2
Periodontitis	1	2
Prostate Cancer	2	2
Pyelonephritis	1	2
Sepsis	2	2
Steatorrhea	1	2
Stress	1	2
Stroke: Ischemic	1	2
Thyroid Diseases	1	2
Toxoplasma gondii Infection	1	2
Toxoplasmosis	1	2
Tumors	2	2
Advanced Glycation End products (AGE)	1	1
Aspergillosis	1	1
Atherosclerosis	1	1
Autism	1	1
Autoimmune Diseases	1	1
Bacillus Cereus infection	1	1
Cancer Stem Cells	1	1
Cancers: Drug Resistant	1	1
Cancers: Radiation-Resistant	1	1
Coxsackievirus Infections	1	1
Dental Implantation	1	1
Drug-Induced Toxicity: Gastrointestinal	1	1
Drug-Induced Toxicity: Indomethacin	1	1
Foodborne Pathogens: Prevention/Food Preservation	1	1
Gastric Cancer	1	1
Glioma	1	1
Huntington Disease	1	1
Influenza	1	1
Klebsiella Infections	1	1
Listeria Infections	1	1
Malaria	1	1
Micrococcus luteus infections	1	1
Oral Cancer	1	1
Organ Transplantation	1	1
Osteoclastoma	1	1
Pseudomonas aeruginosa	1	1
Radiation	1	1
Respiratory Infections	1	1
Rhinovirus Infection	1	1
Salmonella Infections	1	1
Seizures	1	1
Squamous cell carcinoma	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Systemic Lupus Erythematosus	1	1
Thyroid Cancer	1	1
Traumatic Brain Injury	1	1
Wound Healing	1	1
Alopecia: Androgenic	1	0

Name	AC	CK
Anti-Inflammatory Agents	39	83
Antioxidants	33	68
Neuroprotective Agents	32	59
Antiproliferative	28	38
Apoptotic	23	35
Cell cycle arrest	9	19
Tumor Necrosis Factor (TNF) Alpha Inhibitor	13	19
Hypoglycemic Agents	5	17
Hepatoprotective	4	16
Interleukin-1 beta downregulation	10	16
Anti-metastatic	10	15
Hypolipidemic	4	15
NF-kappaB Inhibitor	10	15
Anti-Fibrotic	3	13
Cardioprotective	7	13
Chemopreventive	9	13
Analgesics	2	12
Anti-Apoptotic	7	12
Anticarcinogenic Agents	7	12
Antidepressive Agents	5	12
Postaglandin PGE2 downregulation	2	11
Adiponectin upregulation	1	10
Appetite Suppresant	1	10
Bcl-2 protein down-regulation	2	10
Gastrointestinal Agents	1	10
Interleukin-6 Downregulation	7	10
Photoprotective	2	10
Chemosensitizer	4	8
Immunomodulatory	5	8
Matrix metalloproteinase-2 (MMP-2) inhibitor	3	8
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	8
Antiviral Agents	5	7
Tumor Suppressor Protein p53 Upregulation	2	7
Anticonvulsants	3	6
Chemotherapeutic	4	6
Anti-Bacterial Agents	5	5
Antimicrobial	4	5
Bax/Bcl2 ratio: Increase	1	5
Caspase-3 Activation	1	5
Caspase-9 Activation	1	5
Leishmanicidal	2	5
Pancreato Protective Agents	3	5
Angiogenesis Inhibitors	3	4
Anticholesteremic Agents	2	4
Antispasmodic	2	4
Chemoprotective Agents	2	4
Immunostimulatory	1	4
Insecticides	1	4
Nrf2 activation	3	4
Renoprotective	2	4
Serotonergic	1	4
Acetylcholinesterase Inhibitor	2	3
Antineoplastic Agents	2	3
Gastroprotective	2	3
Multidrug Resistance Gene Modulators	3	3
Vascular Endothelial Growth Factor Inhibitors	2	3
Alpha-amylase inhibitor	1	2
Alpha-glucosidase inhibitor	1	2
Antihypertensive Agents	1	2
Antimutagenic Agents	1	2
Antiparasitic Agents	1	2
Antiprotozoal Agents	1	2
Anxiolytic	1	2
Autophagy Inhibitors	1	2
Cyclooxygenase 2 Inhibitors	2	2
Detoxifier	1	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Genoprotective	1	2
Heme oxygenase-1 up-regulation	1	2
Immunomodulatory: Th17 downregulation	1	2
Insecticidal	1	2
Monoamine Oxidase Inhibitors	1	2
Prophylactic Agents	1	2
STAT3 Inhibitor	1	2
Wnt/β-catenin signaling pathway modulation	2	2
Anti-Glycation Agents	1	1
Anti-atherogenic	1	1
Antifungal Agents	1	1
Antimalarials	1	1
Cyclooxygenase 1 Inhibitor	1	1
Cyclooxygenase Inhibitors	1	1
Endocannabinoid Modulator	1	1
Heme oxygenase-1 inducer	1	1
Interleukin-8 downregulation	1	1
MicroRNA modulator	1	1
Nitric Oxide Inhibitor	1	1
Prostaglandin PGE2 downregulation	1	1
Radioprotective	1	1
Radiosensitizer	1	1
STAT3 Activation	1	1
Transforming growth factor beta (TGF-β) inhibitor	1	1
Wnt/β-catenin pathway down-regulation	1	1

[+]

An essential oil cream made from marjoram, black pepper, lavender, peppermint developed in this study can be used to improve neck pain.Sep 30, 2014

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Pubmed Data : J Altern Complement Med. 2014 Oct ;20(10):771-9. Epub 2014 Sep 5. PMID: 25192562

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Pubmed Data : J Cell Biochem. 2019 Sep ;120(9):15989-15996. Epub 2019 Jun 6. PMID: 31168845

Article Published Date : Aug 31, 2019

Study Type : Human Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective, Hypolipidemic

[+]

Antioxidative effects of piperine against cadmium-induced oxidative stress.Oct 08, 2018

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Pubmed Data : J Diet Suppl. 2018 Oct 9:1-12. Epub 2018 Oct 9. PMID: 30299203

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Pubmed Data : Behav Brain Funct. 2015 ;11:13. Epub 2015 Mar 29. PMID: 25880991

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Black Pepper

Diseases : Alzheimer's Disease, Anxiety Disorders, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Anxiolytic, Neuroprotective Agents

Additional Keywords : Plant Extracts

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A plant extract of Piper nigrum L. fruits ameliorates amyloid beta(1-42)-induced spatial memory impairment by attenuation of the oxidative stress in the rat hippocampus.Mar 31, 2014

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Pubmed Data : Cell Mol Neurobiol. 2014 Apr ;34(3):437-49. Epub 2014 Jan 19. PMID: 24442916

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Pubmed Data : J Family Community Med. 2009 May ;16(2):59-65. PMID: 23012192

Article Published Date : Apr 30, 2009

Study Type : Animal Study

Additional Links

Substances : Black Pepper, Cayenne, Cinnamon Cassia, Turmeric

Diseases : Toxoplasma gondii Infection, Toxoplasmosis

Pharmacological Actions : Antiparasitic Agents, Antiprotozoal Agents

[+]

Antidepressant, anxiolytic, antipyretic, and thrombolytic profiling of methanol extract of the aerial part of Piper nigrum.Jan 31, 2021

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Pubmed Data : Chem Cent J. 2018 Aug 20 ;12(1):94. Epub 2018 Aug 20. PMID: 30123925

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Pubmed Data : Pak J Biol Sci. 2008 Jun 1;11(11):1492-6. PMID: 18817253

Pubmed Data : Curr Pharm Biotechnol. 2016;17(11):962-73. PMID: 27396401

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Pubmed Data : Toxicol Mech Methods. 2008 Jan;18(9):691-6. PMID: 20020926

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : DNA damage, Myelotoxicity

Pharmacological Actions : Genoprotective

Additional Keywords : Natural Substance Synergy

[+]

Cumin and black pepper prevent chemically-induced rat colon carcinogenesis.Jan 01, 2006

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Pubmed Data : J Med Food. 2006;9(2):237-45. PMID: 16822210

Article Published Date : Jan 01, 2006

Study Type : Animal Study

Additional Links

Substances : Black Pepper, Cumin

Diseases : Colon Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

[+]

Curcumin (from Turmeric) in combination with Piperine may attenuate stress-induced depression. Oct 25, 2008

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Pubmed Data : Neurotox Res. 2019 Oct 25. Epub 2019 Oct 25. PMID: 31654381

Article Published Date : Oct 24, 2019

Study Type : Animal Study

Additional Links

Substances : Piperine, Quercetin

Diseases : Parkinson's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Problem Substances : Aluminum Chloride

[+]

Piperine alleviates doxorubicin-induced cardiotoxicity.Dec 31, 2018

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Pubmed Data : Brain Res. 2012 Dec 7 ;1488:38-50. Epub 2012 Oct 23. PMID: 23099054

Article Published Date : Dec 06, 2012

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Cognitive Decline/Dysfunction, Oxidative Stress, Stress

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Increased Bioavailability, Natural Substance Synergy

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Piperine enhanced the neuroprotective effect of curcumin against LPS-induced neurobehavioral and neurochemical deficits.May 31, 2016

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Pubmed Data : Inflammation. 2016 Jun ;39(3):1025-38. PMID: 26970969

Article Published Date : May 31, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Neuroprotective Agents

[+]

Piperine enhances the antioxidant and anti-Inflammatory activities of thymoquinone against microcystin-LR-induced hepatotoxicity and neurotoxicity.Dec 31, 2018

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Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:1309175. Epub 2019 Apr 16. PMID: 31178949

Article Published Date : Dec 31, 2018

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Pubmed Data : J Cardiovasc Pharmacol. 2008 Nov;52(5):452-458. PMID: 19033825

Article Published Date : Nov 01, 2008

Study Type : Animal Study

Additional Links

Substances : Piperine

Pharmacological Actions : Antihypertensive Agents

[+]

Piperine has anticonvulsant effects in-vivo and in-vitro.Sep 02, 2015

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Pubmed Data : Channels (Austin). 2015 Sep 3 ;9(5):317-23. PMID: 26542628

Article Published Date : Sep 02, 2015

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Epilepsy

Pharmacological Actions : Anticonvulsants

[+]

Piperine has protective effects on lead acetate induced-nephrotoxicity in rats.Oct 31, 2017

Pubmed Data : Inflammopharmacology. 2018 Oct 20. Epub 2018 Oct 20. PMID: 30343451

Article Published Date : Oct 19, 2018

Study Type : Animal Study

Additional Links

Substances : Black Pepper

Diseases : Lichen Planus

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Piperine may be a potential anti-inflammatory treatment both in endometritis and in other S. aureus-induced diseases.Dec 31, 2015

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Pubmed Data : Evid Based Complement Alternat Med. 2016 ;2016:8597208. Epub 2016 May 12. PMID: 27293467

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Endometritis, Staphylococcus aureus infection

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

Additional Keywords : Dose Response

[+]

[+]

Piperine pretreatment attenuates renal ischemia-reperfusion induced liver injury.Jul 31, 2019

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Pubmed Data : Life Sci. 2021 Mar 2 ;274:119312. Epub 2021 Mar 2. PMID: 33667521

Article Published Date : Mar 01, 2021

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Pancreato Protective Agents

[+]

Piperine protects lipopolysaccharide-induced mastitis by inhibiting inflammatory response.Jul 20, 2020

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Pubmed Data : Int Immunopharmacol. 2020 Jul 21 ;87:106804. Epub 2020 Jul 21. PMID: 32707496

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Pubmed Data : J Nutr Biochem. 2020 Jan ;75:108261. Epub 2019 Oct 27. PMID: 31710934

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

[+]

Piperine restores streptozotocin-induced cognitive impairments.Jan 29, 2018

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Pubmed Data : Behav Brain Res. 2018 Jan 30 ;337:131-138. Epub 2017 Sep 20. PMID: 28939403

Article Published Date : Jan 29, 2018

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Diabetes: Cognitive Dysfunction, Diabetic Complications

[+]

Piperine supplementation markedly protects erythrocytes from oxidative stress by improving the antioxidant status in high fat fed antithyroid drug treated rats.Nov 01, 2006

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Pubmed Data : Cell Biochem Funct. 2006 Nov-Dec;24(6):491-8. PMID: 16927417

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Pubmed Data : Biochem Pharmacol. 2006 Aug 14;72(4):486-97. Epub 2006 Jun 14. PMID: 16780805

Article Published Date : Aug 14, 2006

Study Type : Animal Study

Additional Links

Substances : Black Pepper, Piperidines

Diseases : Cadmium Poisoning , Heavy Metal Toxicity, Oxidative Stress

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Piperine, a major component of black pepper, inhibits lipopolysaccharide-induced inflammation.Sep 10, 2010

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Pubmed Data : Eur J Pharmacol. 2010 Sep 10;642(1-3):154-62. Epub 2010 Jun 8. PMID: 20621590

Article Published Date : Sep 10, 2010

Study Type : Animal Study

Additional Links

Substances : Black Pepper, Piperine

Diseases : Endotoxemia, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Ann Med. 2021 Dec ;53(1):2009-2017. PMID: 34751064

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Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 6. Epub 2011 Apr 6. PMID: 21477634

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Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:1915-1923. Epub 2018 Nov 26. PMID: 30551446

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Black Pepper

Diseases : Allergic Rhinitis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Immunomodulatory: Th17 downregulation, STAT3 Inhibitor

[+]

These results suggest that piperine free P. nigrum extracts can enhance breast cancer cell response to phytochemicals.May 03, 2016

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Pubmed Data : J Ethnopharmacol. 2016 May 4. Epub 2016 May 4. PMID: 27155135

Article Published Date : May 03, 2016

Pubmed Data : J Complement Integr Med. 2016 Jun 25. Epub 2016 Jun 25. PMID: 27343476

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Pubmed Data : J Pharm Pharmacol. 2019 Jul ;71(7):1162-1171. Epub 2019 May 3. PMID: 31049982

Article Published Date : Jun 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Black Pepper

Diseases : Cancers: All, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Apoptotic

[+]

Antifungal efficacy of spice extracts against Candida albicans.Sep 30, 2019

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Pubmed Data : Indian J Community Med. 2019 Oct ;44(Suppl 1):S77-S80. PMID: 31728098

Article Published Date : Sep 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Bay leaf, Black Pepper, Cinnamon, Cumin

Diseases : Candida Albicans

Pharmacological Actions : Antifungal Agents

[+]

Antimicrobial and synergistic effects of commercial piperine and piperlongumine in combination with conventional antimicrobials.May 03, 2019

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Pubmed Data : Antibiotics (Basel). 2019 May 4 ;8(2). Epub 2019 May 4. PMID: 31060239

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Pubmed Data : J Nat Med. 2013 Apr ;67(2):303-10. Epub 2012 Jun 27. PMID: 22736065

Article Published Date : Mar 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Black Pepper, Piperine

Diseases : High Cholesterol

Pharmacological Actions : Anticholesteremic Agents

Additional Keywords : Plant Extracts

[+]

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2018 Mar 2 ;23(3). Epub 2018 Mar 2. PMID: 29498663

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Pubmed Data : PLoS One. 2015;10(7):e0131321. Epub 2015 Jul 1. PMID: 26132146

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Bay leaf, Black Pepper, Coriandor, Cumin, Garlic, Ginger, Mustard Oil, Onions, Turmeric

Diseases : Bacillus Cereus infection, Escherichia coli Infections, Listeria Infections, Micrococcus luteus infections, Salmonella Infections, Staphylococcus aureus infection

Pharmacological Actions : Anti-Bacterial Agents, Antimicrobial, Antioxidants

Additional Keywords : Essential Oils, Natural Substance Synergy

[+]

Curcumin and piperine demonstrated promising neuroprotective effects.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Aging Neurosci. 2019 ;11:206. Epub 2019 Aug 27. PMID: 31507403

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Pubmed Data : Anticancer Res. 2020 Feb ;40(2):689-694. PMID: 32014909

Article Published Date : Jan 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Pubmed Data : Pestic Biochem Physiol. 2015 Mar ;119:16-27. Epub 2015 Mar 10. PMID: 25868812

Article Published Date : Feb 28, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants

Problem Substances : Deltamethrin

[+]

Piperine enhances the bioavailability of silybin.Sep 27, 2018

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Pubmed Data : Phytomedicine. 2018 Sep 28 ;54:98-108. Epub 2018 Sep 28. PMID: 30668388

Article Published Date : Sep 27, 2018

Study Type : In Vitro Study

Additional Links

Substances : Piperine, Silymarin

Additional Keywords : Food Bioavailability Enhancers

[+]

Piperine exhibits promising antibiofilm activity against Staphylococcus aureus.Dec 22, 2021

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Pubmed Data : Arch Microbiol. 2021 Dec 23 ;204(1):59. Epub 2021 Dec 23. PMID: 34940904

Article Published Date : Dec 22, 2021

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Staphylococcus aureus infection

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation

[+]

Piperine functions as a tumor suppressor for human ovarian tumor growth.Jun 28, 2018

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Pubmed Data : Biosci Rep. 2018 Jun 29 ;38(3). Epub 2018 May 31. PMID: 29717031

Article Published Date : Jun 28, 2018

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Piperine has the capacity to metabolically reprogram peritoneal resident macrophages to fortify their innate functions against bacterial infection.Oct 19, 2015

Pubmed Data : Sci Rep. 2016 Dec 20 ;6:39239. Epub 2016 Dec 20. PMID: 27995955

Article Published Date : Dec 19, 2016

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Antiproliferative, Apoptotic, lung cancer, Piperine

[+]

Piperine may become a potential therapeutic agent against bacterial sepsis.Dec 31, 2015

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Pubmed Data : Front Pharmacol. 2016 ;7:390. Epub 2016 Oct 20. PMID: 27812336

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Pubmed Data : Sci Pharm. 2017 Jul 3 ;85(3). Epub 2017 Jul 3. PMID: 28671634

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Pubmed Data : J Trop Med. 2021 ;2021:9135617. Epub 2021 Oct 11. PMID: 34671402

Article Published Date : Dec 31, 2020

Study Type : Review

Additional Links

Substances : Curcumin, Piperine

Diseases : Malaria

Pharmacological Actions : Anti-Inflammatory Agents, Antimalarials, Antioxidants

[+]

The present study provides useful insight into the apoptotic potential of piperine.Dec 31, 2018

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Pubmed Data : Iran J Public Health. 2021 May ;50(5):1037-1047. PMID: 34183962

Article Published Date : Apr 30, 2021

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

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The use of phytochemicals may be a true therapeutic strategy for eradicating cancer through the elimination of CSCs.Dec 31, 2014

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Pubmed Data : Int J Mol Sci. 2015 ;16(7):15727-42. Epub 2015 Jul 10. PMID: 26184171

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An essential oil cream made from marjoram, black pepper, lavender, peppermint developed in this study can be used to improve neck pain.Sep 30, 2014

Black pepper-based beverage induced appetite-suppressing effects.May 22, 2018

Curcumin and piperine supplementation before and after exercise can attenuate some, but not all, aspects of muscle damage.Feb 28, 2017

Curcuminoids plus piperine modulate adipokines in type 2 diabetes mellitus.Jan 02, 2018

Essential oils of black pepper and angelica reduced the level of nicotine craving and allowed a longer delay before next use of tobacco.Jul 31, 2013

Evaluation of efficacy of curcumin along with lycopene and piperine in the management of oral submucous fibrosis.Jun 30, 2019

Fragrance inhalation of patchouli and rose oil reduce sympathetic nervous system activity by 40%; rose oil reduces adrenaline concentrations by 30%. Nov 01, 2002

Herbal formulation turmeric extract, black pepper, and ginger versus naproxen for chronic knee osteoarthritis.Jul 31, 2020

Inhalation of vapor from black pepper reduces smoking withdrawal symptoms.Feb 01, 1994

Oral curcumin with piperine as adjuvant therapy for the treatment of COVID-19.Dec 31, 2020

Prebiotic potential of culinary spices used to support digestion and bioabsorption.Dec 31, 2018

Short term supplementation with curcuminoid and piperine combination significantly improves oxidative and inflammatory status in patients with MetS.Jan 06, 2015

Simultaneous use of narrowband ultraviolet B and topical piperine has a remarkable effect on treatment of vitiligo.May 20, 2018

The use of piperine-added Curcuma longa L. was effective in the glycaemic and TG control of patients with type 2 diabetes.Feb 13, 2021

This study found that an olfactory stimulus led to improvement of balance ability in the stroke patients.Dec 31, 2014

This study suggested beneficial effects of combined curcuminoids and piperine supplementation on disease severity in patients with NAFLD.Aug 31, 2019

Antioxidative effects of piperine against cadmium-induced oxidative stress.Oct 08, 2018

Piperine attenuates UV-R induced cell damage in human keratinocytes.Jun 30, 2017

Piperine attenuates UV-R induced cell damage in human keratinocytes.Jun 30, 2017

Piperine enhanced mitomycin-C therapy in human cervical cancer cells.Nov 19, 2017

Piperine inhibits the proliferation of human osteosarcoma cells via G2/M phase arrest and prevents metastasis.Dec 31, 2014

Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

Herbal supplement (Combi-5) in the management of COVID 19 individual with mild to moderate symptoms: a case report.May 06, 2021

Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase.Jun 30, 2020

Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination.Jul 14, 2020

Prophylactic effect of resveratrol and piperine on pristane-induced murine model of lupus-like disease.May 31, 2020

A combination of curcumin with piperine exhibited profound cardioprotection compared to curcumin alone-treated group.Dec 31, 2016

A combination of nutrients improves cognitive functioning while decreasing Alzheimer disease neuropathology in an animal model.Jan 01, 2010

A combination of piperine and ferulic acid might be an alternative therapy in the treatment of psychiatric disorders with high efficacy and low side effects.Jul 29, 2015

A methanolic extract of Piper nigrum ameliorates beta-amyloid (1–42)-induced anxiety and depression by attenuation of the oxidative stress in the rat amygdala.Dec 31, 2014

A plant extract of Piper nigrum L. fruits ameliorates amyloid beta(1-42)-induced spatial memory impairment by attenuation of the oxidative stress in the rat hippocampus.Mar 31, 2014

A standardized black pepper seed extract containing β-caryophyllene improves cognitive function in scopolamine-induced amnesia mode.Nov 30, 2021

A traditionally used herbal combination could potentially use as a treatment of cognitive impairment induced by thyroid hormone deficiency.Jul 20, 2020

An extract of curcuma longa showed a 98.6% and 99.2% inhibition of the growth of toxoplasma tachyzoites in 100mg and 200mg doses.Apr 30, 2009

Antidepressant, anxiolytic, antipyretic, and thrombolytic profiling of methanol extract of the aerial part of Piper nigrum.Jan 31, 2021

Antioxidant effects of piperine in in-vivo cataract model induced by steroids.Feb 28, 2019

Anxiolytic and antidepressant-like effects of essential oil from the fruits of Piper nigrum.Mar 31, 2021

Augmentation of hepatoprotective potential of Aegle marmelos in combination with piperine.Aug 19, 2018

Black pepper and cardamom have immunomodulatory and anti-cancer Apr 01, 2010

Black pepper and Vinca rosea protect against alloxan induced diabetes.Jan 01, 2005

Black pepper extract has therapeutic potential for treating allergic asthma through inhibiting Th2/Th17 responses and mast cells activation.Nov 30, 2017

Black pepper has antispasmodic properties.Jun 01, 2008

Black pepper is a potential inducer of detoxification, indicating its role as a chemopreventive in chemical carcinogenesis.Aug 16, 1993

Black pepper may have a therapeutic role in the treatment of gastrointestinal disorders.Dec 01, 2009

Black Pepper reduces high-fat diet induced oxidative stress.Jan 01, 2004

Black pepper shows potential as a larvicide for the control of certain malaria vector species.Dec 31, 2015

Black pepper significantly improved memory in aluminum chloride induced neurotoxicity mouse model.Dec 31, 2015

Both in vivo and in vitro results confirm the efficacy of black pepper, ginger and thyme extracts extracts as natural antimicrobials and suggests the possibility of using them in treatment procedures.Sep 30, 2014

Co-administration of curcumin and piperine may provide a useful natural adjuvant in the antidepressant therapy.Dec 31, 2012

Co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression.Jun 30, 2014

Cucumin and piperine in combination have a potent antigenotoxic effect as compared to either agent alone in DMBA-induced genotoxicity in golden Syrian hamsters.Jan 01, 2008

Cumin and black pepper prevent chemically-induced rat colon carcinogenesis.Jan 01, 2006

Curcumin (from Turmeric) in combination with Piperine may attenuate stress-induced depression. Oct 25, 2008

Curcumin and piperine afforded a better neuroprotective effect compared to each of them alone.Nov 15, 2016

Curcumin and piperine showed strong antioxidant and protective effect against QA-induced behavioural and neurological alteration.Jan 29, 2016

Curcumin and piperine-loaded emulsomes as combinational treatment approach enhance the anticancer activity of curcumin on HCT116 colorectal cancer model.Dec 31, 2019

Curcumin can prevent the formation of cholesterol gallstones induced by high fat diet in mice.Dec 31, 2014

Curcumin in combination with piperine shows better suppression of DENA-induced hepatocellular carcinoma in contrast to curcumin on its own. Jul 25, 2015

Curcumin, capsaicin and piperine have anti-inflammatory effects on H. pylori-induced gastritis in gerbils and may have potential chemoprevention of H. pylori-associated gastric carcinogenesis.Jul 02, 2015

Dichloromethane extraction from Piper nigrum L. and P. longum L. to mitigate ischemic stroke.Aug 07, 2020

Dietary ginger and other spice compounds enhance fat digestion and absorption in high-fat fed situation through enhanced secretion of bile salts and a stimulation of the activity pancreatic lipase.Sep 13, 2011

Dietary piperine suppresses obesity-associated breast cancer growth and metastasis.Dec 28, 2021

Dietary spices have a beneficial effect on intestinal villi by increasing the absorptive surface of the small intestine, providing for an increased bioavailability of micronutrients.Feb 24, 2010

Low piperine fractional piper nigrum extract enhanced the antitumor immunity.Apr 25, 2021

Natural piperine improves lipid metabolic profile of high-fat diet-fed mice.Feb 25, 2021

Neuroprotective Effect of Dichloromethane Extraction From Piper nigrum L. and Piper longum L.Feb 28, 2019

Neuroprotective effect of quercetin in combination with piperine against rotenone-and iron supplement-induced Parkinson's disease.Oct 24, 2019

Neuroprotective effects of black pepper cold-pressed oil on scopolamine-induced oxidative stress and memory impairment.Dec 14, 2021

New insights in vitiligo treatments using bioactive compounds from Piper nigrum.Jan 31, 2019

Oral administration of Curcuma longa associated with white pepper at doses that can be extrapolated to human exposure upon supplementation improves pro-inflammatory disorders.Dec 31, 2012

P. nigrum is a source of potent and safe antileishmanial compounds.Dec 31, 2014

Piper nigrum extract attenuates food allergy by decreasing Th2 cell response and regulating the Th17/Treg balance.Feb 16, 2021

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View the Evidence:
249 Abstracts with Black Pepper Research