Black Pepper

Name	AC	CK
Oxidative Stress	10	29
Diabetes Mellitus: Type 2	6	27
Smoking Cessation: Nicotine Addiction	2	20
Vitiligo	5	16
Inflammation	11	15
Alzheimer's Disease	9	14
Lung Cancer	6	13
Fibrosis	2	12
Cancers: All	9	11
Adrenaline: Elevated	1	10
Adrenaline: Low	1	10
Breast Cancer	7	10
Catecholamines: Elevated	1	10
Catecholamines: Low	1	10
Cognitive Decline/Dysfunction	4	10
Depression	4	10
High Fat Diet	5	10
Hypertension	1	10
Lipopolysaccharide-Induced Toxicity	5	10
Metabolic Diseases	1	10
Muscle Damage: Exercise-Induced	1	10
Neck Pain	1	10
Nonalcoholic fatty liver disease (NAFLD)	1	10
Osteoarthritis: Knee	1	10
Smoking Cessation	1	10
Stroke: Attenuation/Recovery	1	10
Sympathetic Nervous System Diseases	1	10
Ultraviolet Radiation Induced Damage	2	10
Cadmium Poisoning	3	9
Neurodegenerative Diseases	4	8
Obesity	4	8
Parkinson's Disease	5	8
Cerebral Ischemia	3	6
Cervical Cancer	2	6
Colon Cancer	5	6
Colorectal Cancer	5	6
Coronavirus Infection	4	6
Hyperlipidemia	3	6
Liver Cancer	4	6
Staphylococcus aureus infection	5	6
Brain Inflammation	3	5
Leishmaniasis	2	5
Osteosarcoma	1	5
Allergic Rhinitis	2	4
Candida Albicans	4	4
Diabetes: Cognitive Dysfunction	2	4
Endotoxemia	1	4
Epilepsy	2	4
Gastrointestinal Diseases	2	4
Kidney Damage	2	4
Malabsorption Syndrome	1	4
Memory Disorders	2	4
Microvilli atrophy	1	4
Breast Cancer: Triple Negative	3	3
Escherichia coli Infections	3	3
Helicobacter Pylori Infection	2	3
Myocardial Fibrosis	2	3
Pancreatitis	2	3
Triglycerides: Elevated	2	3
Alloxan toxicity	1	2
Aluminum Toxicity	1	2
Anxiety Disorders	1	2
Asthma	1	2
Atopic Dermatitis	1	2
Bacterial Infections	1	2
Bacterial Infections and Mycoses	2	2
Benzo[a]pyrene-induced Toxicity	1	2
Breast Cancer: Chemically-Induced	1	2
Cataract	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Chronic Myeloid Leukemia	2	2
Colitis	1	2
Copper Toxicity	1	2
DNA damage	1	2
Depressive Disorder	1	2
Diabetes Mellitus: Type 1	1	2
Diabetic Complications	1	2
Encephalomyelitis	1	2
Endometritis	1	2
Epilepsy: Drug-Induced	1	2
Fat Malabsorption	1	2
Gallstones	1	2
Gastritis	1	2
HPA Axis Dysregulation	1	2
Heavy Metal Toxicity	1	2
High Cholesterol	1	2
Hyperglycemia	1	2
Hyperthyroidism	1	2
Hypothyroidism	1	2
Indigestion: Fats	1	2
Inflammatory Bowel Diseases	1	2
Insulin Resistance	1	2
Ischemia	1	2
Lead Poisoning	1	2
Leptin Resistance	1	2
Lichen Planus	1	2
Liver Cancer: Prevention	1	2
Liver Damage	1	2
Liver Fibrosis	1	2
Low Immune Function: Natural Killer Cells	1	2
Lupus Nephritis	1	2
Lupus-Like Syndrome	1	2
Mastitis	1	2
Metabolic Syndrome X	1	2
Multiple Sclerosis	1	2
Myelotoxicity	1	2
Myocardial Ischemia	1	2
Ovarian Cancer	2	2
Periodontitis	1	2
Prostate Cancer	2	2
Pyelonephritis	1	2
Sepsis	2	2
Steatorrhea	1	2
Stress	1	2
Stroke: Ischemic	1	2
Thyroid Diseases	1	2
Toxoplasma gondii Infection	1	2
Toxoplasmosis	1	2
Tumors	2	2
Advanced Glycation End products (AGE)	1	1
Aspergillosis	1	1
Atherosclerosis	1	1
Autism	1	1
Autoimmune Diseases	1	1
Bacillus Cereus infection	1	1
Cancer Stem Cells	1	1
Cancers: Drug Resistant	1	1
Cancers: Radiation-Resistant	1	1
Coxsackievirus Infections	1	1
Dental Implantation	1	1
Drug-Induced Toxicity: Gastrointestinal	1	1
Drug-Induced Toxicity: Indomethacin	1	1
Foodborne Pathogens: Prevention/Food Preservation	1	1
Gastric Cancer	1	1
Glioma	1	1
Huntington Disease	1	1
Influenza	1	1
Klebsiella Infections	1	1
Listeria Infections	1	1
Malaria	1	1
Micrococcus luteus infections	1	1
Oral Cancer	1	1
Organ Transplantation	1	1
Osteoclastoma	1	1
Pseudomonas aeruginosa	1	1
Radiation	1	1
Respiratory Infections	1	1
Rhinovirus Infection	1	1
Salmonella Infections	1	1
Seizures	1	1
Squamous cell carcinoma	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Systemic Lupus Erythematosus	1	1
Thyroid Cancer	1	1
Traumatic Brain Injury	1	1
Wound Healing	1	1
Alopecia: Androgenic	1	0

Name	AC	CK
Anti-Inflammatory Agents	39	83
Antioxidants	33	68
Neuroprotective Agents	32	59
Antiproliferative	28	38
Apoptotic	23	35
Cell cycle arrest	9	19
Tumor Necrosis Factor (TNF) Alpha Inhibitor	13	19
Hypoglycemic Agents	5	17
Hepatoprotective	4	16
Interleukin-1 beta downregulation	10	16
Anti-metastatic	10	15
Hypolipidemic	4	15
NF-kappaB Inhibitor	10	15
Anti-Fibrotic	3	13
Cardioprotective	7	13
Chemopreventive	9	13
Analgesics	2	12
Anti-Apoptotic	7	12
Anticarcinogenic Agents	7	12
Antidepressive Agents	5	12
Postaglandin PGE2 downregulation	2	11
Adiponectin upregulation	1	10
Appetite Suppresant	1	10
Bcl-2 protein down-regulation	2	10
Gastrointestinal Agents	1	10
Interleukin-6 Downregulation	7	10
Photoprotective	2	10
Chemosensitizer	4	8
Immunomodulatory	5	8
Matrix metalloproteinase-2 (MMP-2) inhibitor	3	8
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	8
Antiviral Agents	5	7
Tumor Suppressor Protein p53 Upregulation	2	7
Anticonvulsants	3	6
Chemotherapeutic	4	6
Anti-Bacterial Agents	5	5
Antimicrobial	4	5
Bax/Bcl2 ratio: Increase	1	5
Caspase-3 Activation	1	5
Caspase-9 Activation	1	5
Leishmanicidal	2	5
Pancreato Protective Agents	3	5
Angiogenesis Inhibitors	3	4
Anticholesteremic Agents	2	4
Antispasmodic	2	4
Chemoprotective Agents	2	4
Immunostimulatory	1	4
Insecticides	1	4
Nrf2 activation	3	4
Renoprotective	2	4
Serotonergic	1	4
Acetylcholinesterase Inhibitor	2	3
Antineoplastic Agents	2	3
Gastroprotective	2	3
Multidrug Resistance Gene Modulators	3	3
Vascular Endothelial Growth Factor Inhibitors	2	3
Alpha-amylase inhibitor	1	2
Alpha-glucosidase inhibitor	1	2
Antihypertensive Agents	1	2
Antimutagenic Agents	1	2
Antiparasitic Agents	1	2
Antiprotozoal Agents	1	2
Anxiolytic	1	2
Autophagy Inhibitors	1	2
Cyclooxygenase 2 Inhibitors	2	2
Detoxifier	1	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Genoprotective	1	2
Heme oxygenase-1 up-regulation	1	2
Immunomodulatory: Th17 downregulation	1	2
Insecticidal	1	2
Monoamine Oxidase Inhibitors	1	2
Prophylactic Agents	1	2
STAT3 Inhibitor	1	2
Wnt/β-catenin signaling pathway modulation	2	2
Anti-Glycation Agents	1	1
Anti-atherogenic	1	1
Antifungal Agents	1	1
Antimalarials	1	1
Cyclooxygenase 1 Inhibitor	1	1
Cyclooxygenase Inhibitors	1	1
Endocannabinoid Modulator	1	1
Heme oxygenase-1 inducer	1	1
Interleukin-8 downregulation	1	1
MicroRNA modulator	1	1
Nitric Oxide Inhibitor	1	1
Prostaglandin PGE2 downregulation	1	1
Radioprotective	1	1
Radiosensitizer	1	1
STAT3 Activation	1	1
Transforming growth factor beta (TGF-β) inhibitor	1	1
Wnt/β-catenin pathway down-regulation	1	1

[+]

Cancer stem cells as a prognostic biomarker and therapeutic target using curcumin/ piperine extract for multiple myeloma.Sep 30, 2022

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Pubmed Data : Asian Pac J Cancer Prev. 2022 Oct 1 ;23(10):3507-3515. Epub 2022 Oct 1. PMID: 36308377

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Pubmed Data : Food Funct. 2018 May 23 ;9(5):2774-2786. PMID: 29691526

Article Published Date : May 22, 2018

Study Type : Human Study

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Substances : Black Pepper

Pharmacological Actions : Appetite Suppresant

[+]

Curcumin and piperine supplementation before and after exercise can attenuate some, but not all, aspects of muscle damage.Feb 28, 2017

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[+]

Piperine inhibits the proliferation of human osteosarcoma cells via G2/M phase arrest and prevents metastasis.Dec 31, 2014

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Pubmed Data : Int Immunopharmacol. 2015 Jan ;24(1):50-8. Epub 2014 Nov 20. PMID: 25479727

Article Published Date : Dec 31, 2014

Study Type : Human In Vitro

Additional Links

Substances : Piperine

Diseases : Osteosarcoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Cell cycle arrest, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

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Pubmed Data : Tumour Biol. 2014 Apr ;35(4):3305-10. Epub 2013 Nov 24. PMID: 24272201

Article Published Date : Mar 31, 2014

Study Type : Human In Vitro

Additional Links

Substances : Piperine

Diseases : Lung Cancer

Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Selective Cytotoxicity

[+]

Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain.Oct 22, 2022

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Pubmed Data : Behav Brain Funct. 2015 ;11:13. Epub 2015 Mar 29. PMID: 25880991

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Black Pepper

Diseases : Alzheimer's Disease, Anxiety Disorders, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Anxiolytic, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

A plant extract of Piper nigrum L. fruits ameliorates amyloid beta(1-42)-induced spatial memory impairment by attenuation of the oxidative stress in the rat hippocampus.Mar 31, 2014

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Pubmed Data : Cell Mol Neurobiol. 2014 Apr ;34(3):437-49. Epub 2014 Jan 19. PMID: 24442916

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Pubmed Data : J Family Community Med. 2009 May ;16(2):59-65. PMID: 23012192

Article Published Date : Apr 30, 2009

Study Type : Animal Study

Additional Links

Substances : Black Pepper, Cayenne, Cinnamon Cassia, Turmeric

Diseases : Toxoplasma gondii Infection, Toxoplasmosis

Pharmacological Actions : Antiparasitic Agents, Antiprotozoal Agents

[+]

Antidepressant, anxiolytic, antipyretic, and thrombolytic profiling of methanol extract of the aerial part of Piper nigrum.Jan 31, 2021

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Pubmed Data : Chem Cent J. 2018 Aug 20 ;12(1):94. Epub 2018 Aug 20. PMID: 30123925

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Pubmed Data : Pak J Biol Sci. 2008 Jun 1;11(11):1492-6. PMID: 18817253

Pubmed Data : Curr Pharm Biotechnol. 2016;17(11):962-73. PMID: 27396401

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Pubmed Data : Toxicol Mech Methods. 2008 Jan;18(9):691-6. PMID: 20020926

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : DNA damage, Myelotoxicity

Pharmacological Actions : Genoprotective

Additional Keywords : Natural Substance Synergy

[+]

Cumin and black pepper prevent chemically-induced rat colon carcinogenesis.Jan 01, 2006

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Pubmed Data : J Med Food. 2006;9(2):237-45. PMID: 16822210

Article Published Date : Jan 01, 2006

Study Type : Animal Study

Additional Links

Substances : Black Pepper, Cumin

Diseases : Colon Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

[+]

Curcumin (from Turmeric) in combination with Piperine may attenuate stress-induced depression. Oct 25, 2008

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Pubmed Data : Neurotox Res. 2019 Oct 25. Epub 2019 Oct 25. PMID: 31654381

Article Published Date : Oct 24, 2019

Study Type : Animal Study

Additional Links

Substances : Piperine, Quercetin

Diseases : Parkinson's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

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Pubmed Data : Pharmaceutics. 2022 Aug 26 ;14(9). Epub 2022 Aug 26. PMID: 36145547

Article Published Date : Aug 25, 2022

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Piperine attenuated cardiac fibrosis in mice.Mar 31, 2017

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Pubmed Data : Brain Res. 2012 Dec 7 ;1488:38-50. Epub 2012 Oct 23. PMID: 23099054

Article Published Date : Dec 06, 2012

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Cognitive Decline/Dysfunction, Oxidative Stress, Stress

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Increased Bioavailability, Natural Substance Synergy

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Piperine enhanced the neuroprotective effect of curcumin against LPS-induced neurobehavioral and neurochemical deficits.May 31, 2016

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Pubmed Data : J Cardiovasc Pharmacol. 2008 Nov;52(5):452-458. PMID: 19033825

Article Published Date : Nov 01, 2008

Study Type : Animal Study

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Substances : Piperine

Pharmacological Actions : Antihypertensive Agents

[+]

Piperine has anticonvulsant effects in-vivo and in-vitro.Sep 02, 2015

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Pubmed Data : Channels (Austin). 2015 Sep 3 ;9(5):317-23. PMID: 26542628

Article Published Date : Sep 02, 2015

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Epilepsy

Pharmacological Actions : Anticonvulsants

[+]

Piperine has protective effects on lead acetate induced-nephrotoxicity in rats.Oct 31, 2017

Pubmed Data : J Control Release. 2023 Feb 8 ;355:259-272. Epub 2023 Feb 8. PMID: 36739910

Article Published Date : Feb 07, 2023

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Chemobrain, Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Chemoprotective Agents, Neuroprotective Agents

[+]

Piperine may be a novel and effective therapeutic strategy for oral lichen planus.Oct 19, 2018

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Pubmed Data : Inflammopharmacology. 2018 Oct 20. Epub 2018 Oct 20. PMID: 30343451

Article Published Date : Oct 19, 2018

Study Type : Animal Study

Additional Links

Substances : Black Pepper

Diseases : Lichen Planus

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Piperine may be a potential anti-inflammatory treatment both in endometritis and in other S. aureus-induced diseases.Dec 31, 2015

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Pubmed Data : Evid Based Complement Alternat Med. 2016 ;2016:8597208. Epub 2016 May 12. PMID: 27293467

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Endometritis, Staphylococcus aureus infection

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

Additional Keywords : Dose Response

[+]

[+]

Piperine pretreatment attenuates renal ischemia-reperfusion induced liver injury.Jul 31, 2019

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Pubmed Data : Chin J Nat Med. 2021 Jun ;19(6):412-421. PMID: 34092292

Article Published Date : May 31, 2021

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Inflammation, Sciatica

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-1 beta downregulation, MicroRNA modulator, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Piperine's mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle.Nov 14, 2016

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Pubmed Data : Ann Med. 2021 Dec ;53(1):2009-2017. PMID: 34751064

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Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 6. Epub 2011 Apr 6. PMID: 21477634

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Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:1915-1923. Epub 2018 Nov 26. PMID: 30551446

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Black Pepper

Diseases : Allergic Rhinitis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Immunomodulatory: Th17 downregulation, STAT3 Inhibitor

[+]

These results suggest that piperine free P. nigrum extracts can enhance breast cancer cell response to phytochemicals.May 03, 2016

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Pubmed Data : J Ethnopharmacol. 2016 May 4. Epub 2016 May 4. PMID: 27155135

Article Published Date : May 03, 2016

Pubmed Data : J Complement Integr Med. 2016 Jun 25. Epub 2016 Jun 25. PMID: 27343476

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Pubmed Data : J Pharm Pharmacol. 2019 Jul ;71(7):1162-1171. Epub 2019 May 3. PMID: 31049982

Article Published Date : Jun 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Black Pepper

Diseases : Cancers: All, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Apoptotic

[+]

Antifungal efficacy of spice extracts against Candida albicans.Sep 30, 2019

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Pubmed Data : Indian J Community Med. 2019 Oct ;44(Suppl 1):S77-S80. PMID: 31728098

Article Published Date : Sep 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Bay leaf, Black Pepper, Cinnamon, Cumin

Diseases : Candida Albicans

Pharmacological Actions : Antifungal Agents

[+]

Antimicrobial and synergistic effects of commercial piperine and piperlongumine in combination with conventional antimicrobials.May 03, 2019

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Pubmed Data : Antibiotics (Basel). 2019 May 4 ;8(2). Epub 2019 May 4. PMID: 31060239

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Pubmed Data : Molecules. 2018 Mar 2 ;23(3). Epub 2018 Mar 2. PMID: 29498663

Article Published Date : Mar 01, 2018

Study Type : In Vitro Study

Additional Links

Substances : Capsaicin, Piperine

Diseases : Cancers: All

Pharmacological Actions : Chemosensitizer, Multidrug Resistance Gene Modulators

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

[+]

Chemoprevention of prostate cancer by natural agents: evidence from molecular and epidemiological studies.Sep 30, 2019

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Pubmed Data : Anticancer Res. 2019 Oct ;39(10):5231-5259. PMID: 31570421

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Pubmed Data : Front Aging Neurosci. 2019 ;11:206. Epub 2019 Aug 27. PMID: 31507403

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Pubmed Data : Phytother Res. 2023 Jan 31. Epub 2023 Jan 31. PMID: 36720711

Article Published Date : Jan 30, 2023

Study Type : Review

Additional Links

Substances : Curcumin, Piperine

Diseases : Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hypoglycemic Agents, Hypolipidemic

[+]

Delivery of apoptosis-inducing piperine to triple-negative breast cancer cells via Co-polymeric nanoparticles.Jan 31, 2020

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Pubmed Data : Anticancer Res. 2020 Feb ;40(2):689-694. PMID: 32014909

Article Published Date : Jan 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

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Pubmed Data : J Herb Med. 2021 Aug 5:100501. Epub 2021 Aug 5. PMID: 34377631

Article Published Date : Aug 04, 2021

Study Type : Review

Additional Links

Substances : Aloe Vera, Ashwagandha, Black Pepper, Broccoli, Cinnamon, Ginger, Holy Basil, Licorice, Moringa oleifera, Neem, Turmeric

Diseases : Coronavirus Infection

Pharmacological Actions : Immunomodulatory

[+]

Herbal-based nano systems have promising proficiency in treatment of neurodegenerative disorders.Dec 31, 2019

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[+]

Nutraceuticals derived from such spices as turmeric, red pepper, black pepper, licorice, clove, ginger, garlic, coriander, and cinnamon target inflammatory pathways, thereby preventing neurodegenerative diseases.Oct 01, 2011

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Pubmed Data : Mol Neurobiol. 2011 Oct ;44(2):142-59. Epub 2011 Mar 1. PMID: 21360003

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Pubmed Data : Biotechnol Lett. 2020 Jun 4. Epub 2020 Jun 4. PMID: 32500474

Article Published Date : Jun 03, 2020

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, STAT3 Activation

[+]

Piperine derived from Piper nigrum L. inhibits LPS-induced inflammation.Sep 25, 2022

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Piperine increases pentagamavunon-1 anti-cancer activity on 4T1 breast cancer.Nov 30, 2022

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Pubmed Data : Iran J Pharm Res. 2022 Dec ;21(1):e123820. Epub 2022 Feb 4. PMID: 35765510

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Pubmed Data : Fungal Genet Biol. 2017 Aug 19. Epub 2017 Aug 19. PMID: 28830793

Article Published Date : Aug 18, 2017

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Aspergillosis

Pharmacological Actions : Antioxidants

Problem Substances : Aflatoxin

[+]

Piperine inhibits cell proliferation and induces apoptosis of human gastric cancer cells.Dec 30, 2020

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Pubmed Data : Sci Rep. 2020 Jul 15 ;10(1):11681. Epub 2020 Jul 15. PMID: 32669593

Article Published Date : Jul 14, 2020

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Wnt/β-catenin signaling pathway modulation

[+]

Piperine synergistically enhances the effect of temozolomide against temozolomide-resistant human glioma cell lines.Jan 11, 2020

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Pubmed Data : Pharm Biol. 2022 Dec ;60(1):96-107. PMID: 34962450

Article Published Date : Nov 30, 2022

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Antioxidants, Chemoprotective Agents

[+]

The influence of piperine on the radioprotective effect of curcumin in irradiated human lymphocytes.Aug 31, 2019

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Pubmed Data : Iran J Public Health. 2021 May ;50(5):1037-1047. PMID: 34183962

Article Published Date : Apr 30, 2021

Study Type : In Vitro Study

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Substances : Piperine

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

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The use of phytochemicals may be a true therapeutic strategy for eradicating cancer through the elimination of CSCs.Dec 31, 2014

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Pubmed Data : Int J Mol Sci. 2015 ;16(7):15727-42. Epub 2015 Jul 10. PMID: 26184171

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Pubmed Data : Int J Appl Basic Med Res. 2017 Jan-Mar;7(1):67-72. PMID: 28251112

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Black Pepper

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Chemopreventive

Additional Keywords : Antiproliferative, Black Pepper, Chemopreventive, COLORECTAL CANCER, Dose Response

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Cancer stem cells as a prognostic biomarker and therapeutic target using curcumin/ piperine extract for multiple myeloma.Sep 30, 2022

Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients.Dec 31, 2022

An essential oil cream made from marjoram, black pepper, lavender, peppermint developed in this study can be used to improve neck pain.Sep 30, 2014

Black pepper-based beverage induced appetite-suppressing effects.May 22, 2018

Curcumin and piperine supplementation before and after exercise can attenuate some, but not all, aspects of muscle damage.Feb 28, 2017

Curcumin appears to be a complementary treatment option for COVID-19 patients.Dec 31, 2022

Curcuminoids plus piperine modulate adipokines in type 2 diabetes mellitus.Jan 02, 2018

Essential oils of black pepper and angelica reduced the level of nicotine craving and allowed a longer delay before next use of tobacco.Jul 31, 2013

Evaluation of efficacy of curcumin along with lycopene and piperine in the management of oral submucous fibrosis.Jun 30, 2019

Fragrance inhalation of patchouli and rose oil reduce sympathetic nervous system activity by 40%; rose oil reduces adrenaline concentrations by 30%. Nov 01, 2002

Herbal formulation turmeric extract, black pepper, and ginger versus naproxen for chronic knee osteoarthritis.Jul 31, 2020

Inhalation of vapor from black pepper reduces smoking withdrawal symptoms.Feb 01, 1994

Oral curcumin with piperine as adjuvant therapy for the treatment of COVID-19.Dec 31, 2020

Prebiotic potential of culinary spices used to support digestion and bioabsorption.Dec 31, 2018

Short term supplementation with curcuminoid and piperine combination significantly improves oxidative and inflammatory status in patients with MetS.Jan 06, 2015

Simultaneous use of narrowband ultraviolet B and topical piperine has a remarkable effect on treatment of vitiligo.May 20, 2018

The use of piperine-added Curcuma longa L. was effective in the glycaemic and TG control of patients with type 2 diabetes.Feb 13, 2021

This study found that an olfactory stimulus led to improvement of balance ability in the stroke patients.Dec 31, 2014

This study suggested beneficial effects of combined curcuminoids and piperine supplementation on disease severity in patients with NAFLD.Aug 31, 2019

Turmeric supplementation with piperine is more effective than turmeric alone in attenuating oxidative stress and inflammation in hemodialysis.Nov 19, 2022

Antioxidative effects of piperine against cadmium-induced oxidative stress.Oct 08, 2018

Piperine attenuates UV-R induced cell damage in human keratinocytes.Jun 30, 2017

Piperine attenuates UV-R induced cell damage in human keratinocytes.Jun 30, 2017

Piperine enhanced mitomycin-C therapy in human cervical cancer cells.Nov 19, 2017

Piperine inhibits the proliferation of human osteosarcoma cells via G2/M phase arrest and prevents metastasis.Dec 31, 2014

Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain.Oct 22, 2022

Formulation of piperine nanoparticles: in vitro breast cancer cell line and in vivo evaluation.Mar 25, 2022

Herbal supplement (Combi-5) in the management of COVID 19 individual with mild to moderate symptoms: a case report.May 06, 2021

Piperine attenuates cigarette smoke-induced oxidative stress, lung inflammation, and epithelial-mesenchymal transition.Nov 24, 2022

Piperine improves the sensitivity of osteosarcoma cells to doxorubicin.Mar 08, 2023

Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase.Jun 30, 2020

Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination.Jul 14, 2020

Prophylactic effect of resveratrol and piperine on pristane-induced murine model of lupus-like disease.May 31, 2020

A combination of curcumin with piperine exhibited profound cardioprotection compared to curcumin alone-treated group.Dec 31, 2016

A combination of nutrients improves cognitive functioning while decreasing Alzheimer disease neuropathology in an animal model.Jan 01, 2010

A combination of piperine and ferulic acid might be an alternative therapy in the treatment of psychiatric disorders with high efficacy and low side effects.Jul 29, 2015

A methanolic extract of Piper nigrum ameliorates beta-amyloid (1–42)-induced anxiety and depression by attenuation of the oxidative stress in the rat amygdala.Dec 31, 2014

A plant extract of Piper nigrum L. fruits ameliorates amyloid beta(1-42)-induced spatial memory impairment by attenuation of the oxidative stress in the rat hippocampus.Mar 31, 2014

A standardized black pepper seed extract containing β-caryophyllene improves cognitive function in scopolamine-induced amnesia mode.Nov 30, 2021

A traditionally used herbal combination could potentially use as a treatment of cognitive impairment induced by thyroid hormone deficiency.Jul 20, 2020

An extract of curcuma longa showed a 98.6% and 99.2% inhibition of the growth of toxoplasma tachyzoites in 100mg and 200mg doses.Apr 30, 2009

Antidepressant, anxiolytic, antipyretic, and thrombolytic profiling of methanol extract of the aerial part of Piper nigrum.Jan 31, 2021

Antioxidant effects of piperine in in-vivo cataract model induced by steroids.Feb 28, 2019

Anxiolytic and antidepressant-like effects of essential oil from the fruits of Piper nigrum.Mar 31, 2021

Augmentation of hepatoprotective potential of Aegle marmelos in combination with piperine.Aug 19, 2018

Black pepper and cardamom have immunomodulatory and anti-cancer Apr 01, 2010

Black pepper and Vinca rosea protect against alloxan induced diabetes.Jan 01, 2005

Black pepper extract has therapeutic potential for treating allergic asthma through inhibiting Th2/Th17 responses and mast cells activation.Nov 30, 2017

Black pepper has antispasmodic properties.Jun 01, 2008

Black pepper is a potential inducer of detoxification, indicating its role as a chemopreventive in chemical carcinogenesis.Aug 16, 1993

Black pepper may have a therapeutic role in the treatment of gastrointestinal disorders.Dec 01, 2009

Black Pepper reduces high-fat diet induced oxidative stress.Jan 01, 2004

Black pepper shows potential as a larvicide for the control of certain malaria vector species.Dec 31, 2015

Black pepper significantly improved memory in aluminum chloride induced neurotoxicity mouse model.Dec 31, 2015

Both in vivo and in vitro results confirm the efficacy of black pepper, ginger and thyme extracts extracts as natural antimicrobials and suggests the possibility of using them in treatment procedures.Sep 30, 2014

Co-administration of curcumin and piperine may provide a useful natural adjuvant in the antidepressant therapy.Dec 31, 2012

Co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression.Jun 30, 2014

Cucumin and piperine in combination have a potent antigenotoxic effect as compared to either agent alone in DMBA-induced genotoxicity in golden Syrian hamsters.Jan 01, 2008

Cumin and black pepper prevent chemically-induced rat colon carcinogenesis.Jan 01, 2006

Curcumin (from Turmeric) in combination with Piperine may attenuate stress-induced depression. Oct 25, 2008

Curcumin and piperine afforded a better neuroprotective effect compared to each of them alone.Nov 15, 2016

Curcumin and piperine showed strong antioxidant and protective effect against QA-induced behavioural and neurological alteration.Jan 29, 2016

Curcumin and piperine-loaded emulsomes as combinational treatment approach enhance the anticancer activity of curcumin on HCT116 colorectal cancer model.Dec 31, 2019

Curcumin can prevent the formation of cholesterol gallstones induced by high fat diet in mice.Dec 31, 2014

Curcumin in combination with piperine shows better suppression of DENA-induced hepatocellular carcinoma in contrast to curcumin on its own. Jul 25, 2015

Curcumin, capsaicin and piperine have anti-inflammatory effects on H. pylori-induced gastritis in gerbils and may have potential chemoprevention of H. pylori-associated gastric carcinogenesis.Jul 02, 2015

Dichloromethane extraction from Piper nigrum L. and P. longum L. to mitigate ischemic stroke.Aug 07, 2020

Dietary ginger and other spice compounds enhance fat digestion and absorption in high-fat fed situation through enhanced secretion of bile salts and a stimulation of the activity pancreatic lipase.Sep 13, 2011

Dietary piperine suppresses obesity-associated breast cancer growth and metastasis.Dec 28, 2021

Dietary spices have a beneficial effect on intestinal villi by increasing the absorptive surface of the small intestine, providing for an increased bioavailability of micronutrients.Feb 24, 2010

Effect of Piper nigrum essential oil in dextran sulfate sodium (DSS)-induced colitis.Sep 30, 2023

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