Broccoli

Name	AC	CK
Oxidative Stress	49	179
Inflammation	24	91
Prostate Cancer	33	79
Helicobacter Pylori Infection	7	70
Diabetes Mellitus: Type 2	13	65
Breast Cancer	32	62
DNA damage	9	45
Autism Spectrum Disorders	6	44
Air Pollution Linked Toxicity	4	42
Prostate Cancer: Prevention	7	39
Insulin Resistance	6	38
Colon Cancer	17	37
Cancers: All	22	35
Pancreatic Cancer	18	32
Benzene Toxicity	2	30
Gastritis	1	30
Breast Cancer: Triple Negative	8	29
Melanoma	6	29
Bladder Cancer	14	28
Liver Cancer	15	23
Asthma	2	22
Cholesterol: Oxidation	3	22
Diesel Exhaust Particle Toxicity	3	22
Fatty Liver	2	22
Hypertension	2	22
Cardiovascular Disease: Prevention	3	21
Obesity	7	21
Schizophrenia	2	21
Skin Diseases	2	21
Anemia: Sickle Cell	1	20
Hyperinsulinism	1	20
Influenza A	2	20
Lung Cancer	13	20
Prostate: PSA Doubling	2	20
Lipopolysaccharide-Induced Toxicity	12	16
Alzheimer's Disease	7	14
Ovarian Cancer	7	13
Autism	2	12
C-Reactive Protein	2	12
Cancer Metastasis	9	12
Chemotherapy-Induced Toxicity: Cisplatin	5	12
Cognitive Decline/Dysfunction	5	12
Colorectal Cancer	6	12
Gastric Cancer	4	12
Glutathione Deficiency	3	12
Smoking	2	12
Lung Cancer: Prevention	2	11
Bladder Degeneration	1	10
COPD	1	10
Cancers: Drug Resistant	5	10
Cardiovascular Diseases	8	10
Cystic Fibrosis	1	10
Epidermolysis Bullosa	1	10
Fibromyalgia	1	10
High Cholesterol	1	10
Human Influenza	1	10
Insulin Disorders	1	10
Lung Diseases	1	10
Osteoarthritis: Knee	1	10
Overweight	1	10
Psychiatric Disorders	1	10
Pulmonary Fibrosis	1	10
Radical Prostatectomy	1	10
Respiratory Diseases	1	10
Smoke Inhalation Poisoning	1	10
Cadmium Poisoning	4	9
Leukemia	5	9
Chemically-Induced Liver Damage	5	8
Endothelial Dysfunction	3	8
Aging	2	7
Cancers	3	7
Cerebral Ischemia	4	7
Chemotherapy-Induced Toxicity: Doxorubicin	6	7
Colorectal Cancer: Prevention	2	7
Hypoxia	5	7
Ischemia	4	7
Neurodegenerative Diseases	5	7
Acetaminophen (Tylenol) Toxicity	3	6
Adenomatous Polyposis Coli	3	6
Cancer Stem Cells	5	6
Colon Cancer: Prevention	2	6
Depression	2	6
Gastrointestinal Inflammation	2	6
Skin Cancer: Prevention	3	6
Advanced Glycation End products (AGE)	3	5
Aging Skin	2	5
Brain Damage	3	5
Breast Cancer: Estrogen	1	5
Carcinoma: Non-Small-Cell Lung	4	5
Endothelial Damage	1	5
Enterococcus Infections	1	5
Female	1	5
Fetal Alcoholism	1	5
Gastric Cancer: Prevention	1	5
Glioblastoma	4	5
Head and Neck Cancer	4	5
Immune Disorders: Low Immune Function	3	5
Lipid Peroxidation	1	5
Melanoma: Metastatic	2	5
Myocardial Ischemia	3	5
Skin Cancer	4	5
Skin Diseases: Photo-Aging	2	5
Aflatoxicosis	3	4
Alcohol Toxicity	1	4
Aspirin-Induced Toxicity	2	4
Brain Injury: Traumatic	2	4
Brain: Microglial Activation	2	4
Cardiomyopathy	2	4
Depressive Disorder	1	4
Diabetes Mellitus: Type 1	2	4
Diabetic Complications	2	4
Diabetic Nephropathy	2	4
Endometriosis	1	4
Escherichia coli Infections	1	4
Gastric Ulcer	2	4
Hydrogen Peroxide Induced Toxicity	4	4
Intestinal Polyps	2	4
Light Sensitivity	1	4
Memory Disorders	2	4
Multiple Sclerosis	2	4
Muscle Damage: Exercise-Induced	2	4
NSAID-induced toxicity	2	4
Nasopharyngeal Cancer	3	4
Neurologic Disorders	1	4
Nicotine/Tobacco Toxicity	2	4
Nonalcoholic fatty liver disease (NAFLD)	2	4
Organ Transplantation: Pancreatic Islet Cells	2	4
Parkinson's Disease	4	4
Spinal Cord Injuries	2	4
Stroke	2	4
Traumatic Brain Injury	2	4
Bacterial Infections and Mycoses	2	3
Benzo[a]pyrene-induced Toxicity	2	3
Blood-Brain-Barrier Disorders	2	3
Brain Cancer	3	3
Brain Inflammation	2	3
Cervical Cancer	3	3
Chemotherapy-Induced Toxicity	2	3
Diabetes Mellitus: Type 1: Prevention	2	3
Drug-Induced Toxicity: Indomethacin	2	3
Intestinal Diseases	2	3
Liver Damage	2	3
Liver Damage: Aflatoxin-Induced	2	3
Low Disorders: Low TH1	2	3
Multiple Myeloma	2	3
Oral Cancer	2	3
Osteosarcoma	2	3
Petroleum Exposure And Toxicity	2	3
Polycyclic aromatic hydrocarbon (PAH) toxicity	2	3
Rheumatoid Arthritis	2	3
Tumors	2	3
Aging: Heart	1	2
Alcoholic Liver Disease	1	2
Amphetamine Addiction/Withdrawal	1	2
Anxiety Disorders	1	2
Atherosclerosis	1	2
Atopic Dermatitis	1	2
Autoimmune Diseases	1	2
Bladder Dysfunction	1	2
Bladder Outlet Obstruction	1	2
Brain Edema	1	2
Brain Hypoxia	2	2
Breast Cancer: Metastatic	2	2
Cancers: Multi-Drug Resistant	1	2
Carbon Monoxide Poisoning	1	2
Cataract	1	2
Chemical Exposure	1	2
Chemical Weapon Agent Injury	1	2
Chronic Pain	1	2
Colitis	1	2
Coronavirus Infection	1	2
Cyanide Poisoning	1	2
Diabetes: Cataract	1	2
Diabetes: Cognitive Dysfunction	1	2
Diabetes: Memory Problems	1	2
Dioxin Toxicity	1	2
Duchenne's Muscular Dystrophy	1	2
Dyslipidemias	1	2
Encephalomyelitis	1	2
Encephalopathy: Hypoxic	1	2
Epstein-Barr Virus Infections	1	2
Fungal Infection	1	2
Furan Toxicity	1	2
Gastrointestinal Cancer	1	2
Glioma	2	2
Gout	1	2
Heart Failure	1	2
Heavy Metal Toxicity	1	2
High Fat Diet	1	2
Hypoglycemia	2	2
Hypogonadism	1	2
Immune Dysregulation: TH1/TH2 imbalance	1	2
Infertility: Male	1	2
Intoxication	1	2
Kidney Diseases	1	2
Lead Poisoning	1	2
Learning disorders	1	2
Liver Disease	1	2
Liver Disease: Oxidative Stress	1	2
Low Immune Function: Natural Killer Cells	1	2
Malathion Toxicity	1	2
Mercury Poisoning	1	2
Mitochondrial Dysfunction	1	2
Muscle Fatigue	1	2
Muscle Soreness	1	2
Musculoskeletal Diseases	1	2
Myocardial Infarction	1	2
Nephropathy	1	2
Neuropathic Pain	1	2
Organ Transplantation	1	2
Osteoporosis	1	2
Placental Insufficiency	1	2
Promyelocytic leukemia	2	2
Pulmonary Hypertension	1	2
Respiratory Syncytial Virus Infections	1	2
Respiratory Tract Infections	1	2
Salivary Gland Adenoid Cystic Carcinoma.	2	2
Salivary Gland Diseases	2	2
Schwannoma: Vestibular	1	2
Seizures	1	2
Serotonin Disorders	1	2
Sickle Cell Anemia	1	2
Stroke: Recovery	1	2
Testicular Injury: Cadmium-Induced	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Ulcerative Colitis	1	2
Ultraviolet Radiation Induced Damage	2	2
Acne	1	1
Allergies	1	1
Androgen-Induced Diseases	1	1
Aortic Plaques	1	1
Arsenic Poisoning	1	1
Bone Destructive Diseases: Over-Active Osteoclasts	1	1
Brain Injury: Hippocampal Damage	1	1
Brain: Oxidative Stress	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Breast Cancer: Prevention	1	1
Candida Infection	1	1
Cardiac Hypertrophy	1	1
Cholesterol: LDL/HDL ratio	1	1
Chronic Kidney Disease (CKD)	1	1
Colorectal Tumors	1	1
Dopamine Deficiency	1	1
Drug-Induced Toxicity	1	1
Dysbiosis: Bifidobacteria Deficiency	1	1
Dystrophic retinal detachment (DRD)	1	1
Excitotoxicity	1	1
Fibrosis	1	1
Gastrointestinal Diseases	1	1
Gram-Negative Bacterial Infections	1	1
Gram-Positive Bacterial Infections	1	1
HDL: Low	1	1
HIV Infections	1	1
Hepatitis C	1	1
Heterocyclic Aromatic Amine Induced Toxicity	1	1
Hyperglycemia	1	1
IgE-Mediated Hypersensitivity	1	1
Keloid	1	1
Kidney Damage	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Liver Cancer: Prevention	1	1
Liver Failure: Acute	1	1
Liver Fibrosis	1	1
Lymphoma	1	1
Macular Degeneration	1	1
Malignant Melanoma	1	1
Medulloblastoma	1	1
Melanism	1	1
Microcystis aeruginosa	1	1
Mitochondrial Diseases	1	1
Muscle Atrophy	1	1
Neurological Conditions	1	1
Oral Cancer: Prevention	1	1
Osteoarthritis	1	1
Osteoporosis: Over-active Osteoclasts	1	1
Pancreatic Cancer Stem Cell	1	1
Pesticide Toxicity	1	1
Prediabetes	1	1
Restenosis	1	1
Retinal Diseases	1	1
Schizophrenic Disorders	1	1
Squamous cell carcinoma	1	1
Stomach Cancer	1	1
Striatonigral Degeneration: Autosomal Dominant	1	1
Sunburn	1	1

Name	AC	CK
Antioxidants	107	311
Anticarcinogenic Agents	93	240
Anti-Inflammatory Agents	64	222
Apoptotic	99	173
Chemopreventive	69	168
Nrf2 activation	71	168
Antiproliferative	70	135
Neuroprotective Agents	45	108
Phase II Detoxification Enzyme Inducer	19	60
Antioxidant Effects	14	49
Cell cycle arrest	33	45
Hepatoprotective	16	45
NF-kappaB Inhibitor	25	38
Anti-Bacterial Agents	6	36
Interleukin-6 Downregulation	18	35
Tumor Necrosis Factor (TNF) Alpha Inhibitor	20	35
Chemotherapeutic	23	33
Detoxifier	4	32
Cytoprotective	5	31
Cardioprotective	15	29
Anti-metastatic	18	27
Interleukin-1 beta downregulation	15	25
Chemosensitizer	17	24
Histone deacetylase inhibitor	14	24
Cyclooxygenase 2 Inhibitors	15	23
Glutathione Upregulation	5	22
Antineoplastic Agents	12	21
Immunomodulatory	7	21
Anti-Allergic Agents	1	20
Gastrointestinal Agents	7	20
Insulin Down-Regulation	1	20
NF-E2-Related Factor-2 (Nrf2) Modulator	11	17
Enzyme Inhibitors	7	16
Genoprotective	3	16
Malondialdehyde Down-regulation	3	16
Matrix metalloproteinase-2 (MMP-2) inhibitor	6	16
MicroRNA modulator	15	16
Anti-Angiogenic	6	14
Anti-Apoptotic	6	14
Insulin Sensitizers	3	14
Antioxidant	4	13
Glucose Uptake Optimization	3	13
Hypolipidemic	2	12
Superoxide Dismutase Up-regulation	3	11
Anticholesteremic Agents	1	10
Chondroprotective	1	10
Glutathione S-transferase Inhibitor	1	10
Heme oxygenase-1 up-regulation	8	10
Anti Inflammatory	4	9
Tumor Suppressor Protein p53 Upregulation	5	9
Matrix metalloproteinase-9 (MMP-9) inhibitor	6	8
Anti-Tumor	2	7
Autophagy Up-regulation	3	7
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	4	7
Renoprotective	5	7
Anti-Proliferative	2	6
Antidepressive Agents	2	6
Chemoprotective Agents	5	6
Vascular Endothelial Growth Factor Inhibitors	2	6
Wnt/β-catenin pathway down-regulation	2	6
Anti-cancer	1	5
HER-2 oncoprotein down-regulation	1	5
Hypoxia-inducible factor-1 (HIF-1) inhibitor	1	5
Immune Enhancing Properties	1	5
Interferon Gamma Reducer	2	5
NADPH Oxidase Inhibitors	1	5
Prostaglandin E Synthase-1 (PGES-1) Down-Regulation	1	5
Radioprotective	2	5
Regenerative	1	5
Wnt/β-catenin signaling pathway modulation	3	5
Anti-Ulcer Agents	2	4
Antimicrobial	1	4
Antiviral Agents	3	4
Bcl-2 protein down-regulation	4	4
Hypoglycemic Agents	3	4
Immunomodulatory: Th17 downregulation	2	4
Interleukin-10 downregulation	1	4
Nitric Oxide Inhibitor	2	4
PI3K-AKT inhibitor	1	4
Phase I Detoxification Enzyme Inducer	2	4
Anti-Fibrotic	3	3
Anti-Glycation Agents	2	3
Interleukin-10 upregulation	2	3
Telomerase Inhibitor	3	3
Acetylcholinesterase Inhibitor	1	2
Angiogenesis Inhibitors	1	2
Anti-Anxiety Agents	1	2
Anticonvulsants	1	2
Antifungal Agents	1	2
Antinoceceptive	1	2
Autophagy Inhibitors	1	2
Brain-derived neurotrophic factor modulator	1	2
Cytotoxic	2	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Fertility Agents: Male	1	2
Gastroprotective	1	2
Heat Shock Protein Inducer	1	2
Hypotensive	1	2
Interleukin-17 downregulation	1	2
Interleukin-18 down-regulation	1	2
Interleukin-2 upregulation	1	2
Interleukin-23 Downregulation	1	2
Leptin Down-Regulation	1	2
Lipolytic	1	2
Malonaldehyde (MDA) Down-Regulation	1	2
Metallothionein Up-regulation	1	2
Neurogenesis	1	2
Osteoprotective	1	2
Pancreato Protective Agents	1	2
Peroxisome Proliferators	1	2
Platelet aggregation inhibitor: collagen-induced aggregation	1	2
Prostaglandin PGE2 downregulation	1	2
Proteasome Inhibitors	2	2
Serotonergic	1	2
Alpha-glucosidase inhibitor	1	1
Antimitotic Agents	1	1
Beta-Defensin-2 Up-Regulation	1	1
Caspase-3 Activation	1	1
Cell Differentiation Inducer	1	1
Estrogen Receptor Modulators	1	1
Immunostimulatory	1	1
Interleukin-4 upregulation	1	1
Interleukin-8 downregulation	1	1
P21 Activation	1	1
Postaglandin PGE2 downregulation	1	1
Quinone Reductase-Inducer	1	1
Radiopharmaceuticals	1	1
Radiosensitizer	1	1
Survivin Down-Regulation	1	1
Vascular Cell Adhesion Molecule-1 Inhibitor	1	1
Vascular Endothelial Growth Factor Regulator	1	1

[+]

Sulforaphane ameliorates lipid profile.Apr 07, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2021 Apr 8 ;11(1):7804. Epub 2021 Apr 8. PMID: 33833347

Article Published Date : Apr 07, 2021

Study Type : Meta Analysis, Review

Additional Links

Substances : Sulforaphane

Diseases : Cardiovascular Diseases, Hypertension, Nonalcoholic fatty liver disease (NAFLD), Obesity

Pharmacological Actions : Hypolipidemic

[+]

Sulforaphane exhibits potent renoprotective effects in preclinical models of kidney diseases.May 31, 2023

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Pubmed Data : Life Sci. 2023 Jun 1 ;322:121664. Epub 2023 Apr 5. PMID: 37023957

Article Published Date : May 31, 2023

Study Type : Meta Analysis, Review

Additional Links

Substances : Sulforaphane

Diseases : Kidney Diseases

Pharmacological Actions : Renoprotective

[+]

Substances : Broccoli, Green Tea, Polyphenols, Pomegranate, Turmeric

Diseases : Prostate: PSA Doubling, Prostate Cancer

Additional Keywords : Supplements

[+]

Accumulation of sulforaphane and alliin in human prostate tissue. Aug 09, 2022

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Pubmed Data : Nutrients. 2022 Aug 10 ;14(16). Epub 2022 Aug 10. PMID: 36014767

Broccoli sprout powder supplemention in type 2 diabetes could have favorable effects on lipid profiles and OX-LDL/LDL ratioMay 31, 2012

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Pubmed Data : Nutr Cancer. 2014 ;66(6):1030-7. Epub 2014 Aug 1. PMID: 25085257

Article Published Date : Dec 31, 2013

Study Type : Human Study

Additional Links

Substances : Broccoli, Green Leafy Vegetables, Pumpkin

Diseases : Lung Cancer: Prevention

Additional Keywords : Risk Reduction

[+]

Cruciferous vegetable consumption was strongly associated with reduced risk of prostate cancer progression.Jun 30, 2012

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Pubmed Data : Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2023 Mar 1 ;44(1):7-16. Epub 2023 Mar 29. PMID: 36987766

Article Published Date : Feb 28, 2023

Study Type : Human Study

Additional Links

Substances : Lycopene, Reishi Mushroom, Resveratrol, Sulforaphane

Diseases : Inflammation, Oxidative Stress

Pharmacological Actions : Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Effects of sulforaphane intake on processing speed and negative moods in healthy older adults.Dec 31, 2021

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Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2001 May ;10(5):501-8. PMID: 11352861

Article Published Date : Apr 30, 2001

Study Type : Human Study

Additional Links

Substances : Broccoli Sprouts

Pharmacological Actions : Anticarcinogenic Agents

Additional Keywords : Isothiocyanates

[+]

Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli.Dec 31, 2017

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Pubmed Data : Am J Clin Nutr. 2019 Jul 3. Epub 2019 Jul 3. PMID: 31268126

Article Published Date : Jul 03, 2019

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Pubmed Data : Phytother Res. 2003 Jan;17(1):66-9. PMID: 20810543

Article Published Date : Jan 01, 2003

Study Type : Human Study

Additional Links

Substances : Sulforaphane

Diseases : Bladder Cancer, Bladder Degeneration, DNA damage

Pharmacological Actions : Chemopreventive, Genoprotective

[+]

Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.Dec 31, 2014

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Pubmed Data : Clin Psychopharmacol Neurosci. 2015 Apr 30 ;13(1):62-7. PMID: 25912539

Article Published Date : Apr 29, 2015

Study Type : Human Study

Additional Links

Substances : Broccoli Sprouts, Sulforaphane

Diseases : Schizophrenia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Plant Extracts, Significant Treatment Outcome

[+]

Supplementation with sulforaphane rich broccoli sprout extract could improve liver function through reduction of oxidative stress.Nov 20, 2015

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Pubmed Data : World J Gastroenterol. 2015 Nov 21 ;21(43):12457-67. PMID: 26604653

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Pubmed Data : Nutrients. 2021 Apr 17 ;13(4). Epub 2021 Apr 17. PMID: 33920642

Article Published Date : Apr 16, 2021

Study Type : Human Study

Additional Links

Substances : Broccoli Sprouts

Diseases : Allergic Rhinitis

Pharmacological Actions : Anti-Allergic Agents

Additional Keywords : Plant Extracts

[+]

The results of this study found that dosing twice a day may be important for increasing or prolonging certain chemopreventive benefits associated with sulforaphane consumption.Feb 28, 2015

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Sulforaphane delays fibroblast aging in vitro by decreasing glycolysis and reducing oxidative stress.Jan 01, 2018

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Pubmed Data : FEBS Open Bio. 2018 Dec ;8(12):2022-2034. Epub 2018 Nov 14. PMID: 30524952

Article Published Date : Dec 01, 2018

Study Type : Human In Vitro

Additional Links

Substances : Sulforaphane

Diseases : Breast Cancer: Estrogen

Additional Keywords : Estrogen Positive Breast Cancer, Folate, Methylation

[+]

Sulforaphane prevents hepatic insulin resistance through a ceramide-dependent mechanism.May 27, 2019

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Pubmed Data : Nutrients. 2019 May 27 ;11(5). Epub 2019 May 27. PMID: 31137828

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Pubmed Data : Curr Pharm Des. 2012 Aug 23. Epub 2012 Aug 23. PMID: 22950492

Article Published Date : Aug 22, 2012

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Aspirin-Induced Toxicity , NSAID-induced toxicity

[+]

A broccoli extract enriched diet increases antioxidant enzyme activities and exerts an antioxidant effect towards cholesterol oxidation in rat liver.Apr 11, 2016

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Pubmed Data : J Steroid Biochem Mol Biol. 2016 Apr 12. Epub 2016 Apr 12. PMID: 27084531

Article Published Date : Apr 11, 2016

Study Type : Animal Study

Additional Links

Substances : Broccoli

Diseases : Cholesterol: Oxidation, Liver Disease: Oxidative Stress

Therapeutic Actions : Exercise

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

[+]

A variety of vegetables reduce the absorption and enhance excretion of dioxin and furan toxins. May 01, 1999

Pubmed Data : Br J Pharmacol. 2018 08 ;175(16):3333-3346. Epub 2018 Jul 3. PMID: 29797311

Article Published Date : Jan 01, 2018

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Stroke

Pharmacological Actions : Platelet aggregation inhibitor: collagen-induced aggregation

Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables

[+]

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.Sep 28, 2006

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Pubmed Data : Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID: 16386831

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Pubmed Data : Cell Death Dis. 2016 ;7(6):e2246. Epub 2016 Jun 2. PMID: 27253410

Article Published Date : Dec 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Quercetin, Sulforaphane

Diseases : Cancers: Drug Resistant, Pancreatic Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis.Sep 30, 2017

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Pubmed Data : J Funct Foods. 2017 Oct ;37:685-698. Epub 2017 Sep 1. PMID: 29242716

Article Published Date : Sep 30, 2017

Study Type : Animal Study

Additional Links

Substances : Broccoli

Diseases : Colitis

Pharmacological Actions : Gastrointestinal Agents

Additional Keywords : Microbiota

[+]

Additional Keywords : Plant Extracts

[+]

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Pubmed Data : Biogerontology. 2022 Oct ;23(5):587-613. Epub 2022 Aug 12. PMID: 35960458

Article Published Date : Sep 30, 2022

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Brain: Oxidative Stress, Cognitive Decline/Dysfunction

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Prophylactic Agents

[+]

Maternal dietary supplementation with BrSp prevented the detrimental neurocognitive and neuropathologic effects of chronic intrauterine ischemia.Sep 14, 2015

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Pubmed Data : Behav Brain Res. 2015 Sep 15 ;291:289-98. Epub 2015 May 23. PMID: 26014855

Article Published Date : Sep 14, 2015

Study Type : Animal Study

Additional Links

Substances : Broccoli Sprouts

Diseases : Encephalopathy: Hypoxic, Placental Insufficiency

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Obesity may increase susceptibility to chronic pain often due to poor diet.Dec 31, 2017

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Pubmed Data : J Surg Res. 2016 Jun 15 ;203(2):348-59. Epub 2016 Mar 24. PMID: 27363643

Article Published Date : Jun 14, 2016

Study Type : Animal Study

Additional Links

Substances : Sulforaphane, Thymoquinone

Diseases : Gastric Ulcer

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Anti-Ulcer Agents, Antioxidants, Gastroprotective

[+]

Profile of insulin resistance in adipose tissue of diet induced obese mice in response to anti-obesity treatment.Apr 30, 2022

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Pubmed Data : FASEB J. 2022 May ;36 Suppl 1. PMID: 35559539

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Pubmed Data : Saudi J Biol Sci. 2020 Nov ;27(11):3145-3149. Epub 2020 Jul 14. PMID: 33100876

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Pubmed Data : Front Pharmacol. 2022 ;13:811257. Epub 2022 Mar 1. PMID: 35300301

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Retinitis Pigmentosa

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

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Sulforaphane alleviated vascular remodeling in hypoxic pulmonary hypertension.Dec 31, 2022

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Pubmed Data : J Nutr Biochem. 2023 Jan ;111:109182. Epub 2022 Oct 9. PMID: 36220525

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Pubmed Data : Curr Pharm Des. 2017 Feb 6. Epub 2017 Feb 6. PMID: 28176666

Article Published Date : Feb 05, 2017

Study Type : Animal Study

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Substances : Sulforaphane

Diseases : Aspirin-Induced Toxicity , Drug-Induced Toxicity: Indomethacin, Helicobacter Pylori Infection, NSAID-induced toxicity

Pharmacological Actions : Antioxidants

Problem Substances : Aspirin , Indomethacin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

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Sulforaphane could ameliorate the progression of hyperuricemia.Nov 09, 2022

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Pubmed Data : Inflammation. 2018 Aug ;41(4):1460-1476. PMID: 29704151

Article Published Date : Aug 01, 2018

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Inflammation, Oxidative Stress

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-10 upregulation, Malonaldehyde (MDA) Down-Regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Neuroprotective Agents, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Superoxide Dismutase Up-regulation

Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates

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Sulforaphane elicits insulin-sensitizing, hepatoprotective, and vasculoprotective effects comparable to that of pioglitazone in insulin-resistant rats.Feb 01, 2019

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Pubmed Data : Environ Toxicol Pharmacol. 2019 Feb ;66:43-54. Epub 2018 Dec 13. PMID: 30597379

Article Published Date : Feb 01, 2019

Study Type : Animal Study

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Pubmed Data : Mol Nutr Food Res. 2019 02 ;63(4):e1800795. Epub 2019 Jan 11. PMID: 30578708

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Pharmacological Actions : Chemopreventive

Additional Keywords : Cancer Stem Cells

[+]

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Pubmed Data : Food Funct. 2018 Sep 19 ;9(9):4695-4701. PMID: 30091431

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Sulforaphane protects against cisplatin-induced liver and mitochondrial damage. Aug 15, 2011

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Pubmed Data : Toxicology. 2011 Aug 15 ;286(1-3):20-7. Epub 2011 May 6. PMID: 21575670

Article Published Date : Aug 15, 2011

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Pubmed Data : Diabetes Metab J. 2021 Jun 4. Epub 2021 Jun 4. PMID: 34082508

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Pubmed Data : Phytother Res. 2008 Aug 11. PMID: 19948220

Article Published Date : Aug 11, 2008

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Myocardial Infarction, Myocardial Ischemia

Pharmacological Actions : Antioxidants

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Sulforaphane protects liver injury induced by intestinal ischemia in an animal model. Jun 28, 2010

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Pubmed Data : World J Gastroenterol. 2010 Jun 28;16(24):3002-10. PMID: 20572303

Article Published Date : Jun 28, 2010

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Intestinal Diseases, Liver Disease

Pharmacological Actions : Anticarcinogenic Agents, Antioxidants

[+]

Sulforaphane protects piglet brains from neonatal hypoxic-ischemic injury.Dec 09, 2020

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Pubmed Data : Dev Neurosci. 2020 Dec 10:1-11. Epub 2020 Dec 10. PMID: 33302269

Article Published Date : Dec 09, 2020

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Ischemia

Pharmacological Actions : Antioxidants, Nrf2 activation

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Sulforaphane ameliorates lipid profile.Apr 07, 2021

Sulforaphane exhibits potent renoprotective effects in preclinical models of kidney diseases.May 31, 2023

Evidence exists indicating that Brassica vegetables reduce prostate cancer risk.Jan 01, 2002

Greater long-term intake and increased consumption of whole fruits may reduce the risk of developing hypertension.Jan 31, 2016

Sulforaphane and EGCG restore estrogen receptor expression by modulating epigenetic events in the breast cancer cell line MDA-MB-231.Oct 17, 2017

In vitro effects of sulforaphane on interferon-driven inflammation and exploratory evaluation in two healthy volunteers.Jun 11, 2021

10-day broccoli consumption has a significant effect on the inflammatory status of young healthy smokers.Jan 31, 2014

A broccoli seed and sprout extract significantly upregulated detoxification of the tobacco carcinogens benzene, acrolein, and crotonaldehyde.Apr 23, 2022

A broccoli sprout beverage rapidly enhanced the detoxication of the airborne pollutants benzene, acrolein, and crotonaldehyde.Jun 08, 2014

A combination of ascorbigen (a food derived form of vitamin c) and broccoli powder reduces pain sensivitiy and improves quality of life in patients with fibromyalgia. Oct 01, 2000

A human clinical study demonstrates that diets rich in cruciferous vegetables may reduce the risk of prostate cancer.Jan 01, 2008

A polyphenol-rich whole food supplement significantly effected the rate of PSA progression among men with prostate cancer.Mar 10, 2014

Accumulation of sulforaphane and alliin in human prostate tissue. Aug 09, 2022

After 4 weeks consuming broccoli sprouts powder it resulted in a significant decrease in serum insulin concentration in patients. Oct 31, 2012

Broccoli consumption affects the human gastrointestinal microbiota.Dec 31, 2018

Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status.Mar 31, 2019

Broccoli sprout extract represents an attractive therapeutic candidate for K14-associated epidermolysis bullosa simplex.Feb 28, 2017

Broccoli sprout homogenate is safe in stable SCD patients and may induce changes in gene expression levels.Dec 31, 2015

Broccoli sprout homogenates increases virus-induced peripheral blood NK cell granzyme B production.Dec 31, 2015

Broccoli sprout powder supplemention in type 2 diabetes could have favorable effects on lipid profiles and OX-LDL/LDL ratioMay 31, 2012

Broccoli sprouts have a positive effect on the nasal response to live attenuated influenza virus in smokers.Dec 31, 2013

Broccoli sprouts may enhance detoxication of airborne pollutants and attenuate their associated health risks.Dec 31, 2011

Broccoli sprouts powder had a considerable effect on H.pylori eradication and related inflammation and could reduce the unfavorable effects of standard triple therapy.Dec 31, 2013

Broccoli sprouts powder led to a significant decrease in oxidative stress and oxidized low density lipoprotein cholesterol in type 2 diabetes patients.Jul 31, 2011

Broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Apr 01, 2009

Consumption of broccoli sprouts modulated the excretion of biomarkers linked to inflammation and vascular reactions.Apr 14, 2015

consumption of specific green leafy vegetables and other vegetables might be associated with a reduced risk of lung cancer. Dec 31, 2013

Cruciferous vegetable consumption was strongly associated with reduced risk of prostate cancer progression.Jun 30, 2012

Daily administration of free sulforaphane shows promise in managing biochemical recurrences in prostate cancer after radical prostatectomy.May 11, 2015

Effect of a sulforaphane supplement on muscle soreness and damage induced by eccentric exercise.Jan 11, 2021

Effect of supplemental antioxidant-based therapy on the oxidative stress level in COVID-19 patients.Feb 28, 2023

Effects of sulforaphane intake on processing speed and negative moods in healthy older adults.Dec 31, 2021

Efficacy of sulforaphane in treatment of children with autism spectrum disorder.Nov 23, 2022

Enhancing sulforaphane absorption and excretion in healthy men through the combined consumption of fresh broccoli sprouts and a gApr 30, 2012

Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients.Apr 23, 2018

Evidence from two independent human studies indicates that consumption of high glucoraphanin broccoli significantly reduces plasma LDL-C.Apr 30, 2015

Healthy volunteers chewed broccoli sprouts exposed the glucosinolates to plant myrosinase and significantly increased dithiocarbamate excretion.Apr 30, 2001

Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli.Dec 31, 2017

IL-6 levels significantly decreased with 70 days of broccoli consumption.Mar 12, 2018

Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint.Jan 12, 2017

Oral broccoli sprouts have significant therapeutic value in the treatment of Helicobacter pylori infection. Aug 01, 2004

Oral chronic sulforaphane effects on heavy resistance exercise.Sep 30, 2021

Oral sulforaphane safely and effectively induces mucosal Phase II enzyme expression in the upper airway of human subjects. Mar 01, 2009

Raw broccoli results in faster absorption, higher bioavailability, and higher peak plasma amounts of sulforaphane, compared to cooked broccoli.Nov 26, 2008

Safety Study: Brocolli sprouts (sulforaphane) are safe, tolerable and do not adversely effect thyroid hormone levels.Jan 01, 2006

Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder.Apr 28, 2020

Sulforaphane detoxifies benzene, an air pollutant, in a dose-dependent manner and may attentuate attenuate associated long-term health risks of air pollution. Jul 03, 2019

Sulforaphane from broccoli was able to reduce some of the symptoms of autism.Dec 31, 2016

Sulforaphane has a novel chemopreventive mechanism in human colon cancer cells and prostate epithelial cells, namely the inhibition of histone deacetylase (HDAC). IFeb 01, 2007

Sulforaphane may improve endothelial function and blood pressure in women with pregnancy hypertension.Apr 30, 2021

Sulforaphane promotes white matter plasticity and improves long-term neurological outcomes after ischemic stroke.Nov 19, 2022

Sulforaphane protects against chemically-induced damage in bladder cells and tissues. Jan 01, 2003

Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.Dec 31, 2014

Sulforaphane-containing broccoli sprout extracts induce a cytoprotective phase 2 response in mouse and human skin.Apr 01, 2007

Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles.Dec 31, 2013

Sulforaphane’s capacity to activate the Keap1–Nrf2 cytoprotective signaling pathway, and may protect against environmental and endogenous risk factors in autism spectrum disorders.Oct 27, 2014

Supplementation therapy of sulforaphane rich broccoli sprout extract may have the potential to improve cognitive deficits in patients with schizophrenia. Apr 29, 2015

Supplementation with sulforaphane rich broccoli sprout extract could improve liver function through reduction of oxidative stress.Nov 20, 2015

The bioavailability of isothiocyanates from fresh broccoli is approximately three times greater than that from cooked broccoli,Jan 01, 2000

The bioavailability of sulforaphane from glucoraphanin supplements was equal to that from broccoli sprouts.Dec 31, 2014

The effect of broccoli sprout extract on seasonal grass pollen-induced allergic rhinitis.Apr 16, 2021

The results of this study found that dosing twice a day may be important for increasing or prolonging certain chemopreventive benefits associated with sulforaphane consumption.Feb 28, 2015

These data indicate that cruciferous vegetables may play an important role in decreasing the risk of premenopausal breast cancer.Apr 30, 2004

Week-long oral administration of sulforaphane increased blood and thalamic glutathione levels in healthy human subjects.May 01, 2018

A diet rich in sulforaphane and related mustard oils may be considered as a supportive nutritional strategy to enhance therapeutic efficacy in patients suffering from pancreatic cancer.Mar 29, 2014

Broccoli sprouts is a rich source of antioxidants that improves the defensive system against oxidative stress in the human colon mucosa.Jun 30, 2015

Combination of epigallocatechin gallate and sulforaphane dounteracts In Vitro oxidative stress and delays stemness loss of amniotic fluid stem cells.Jan 01, 2018

Electron microscopy revealed that both plantain and broccoli markedly reduced E. coli translocation across cells, while the emulsifier Polysorbate-80 increased E. coli translocation.Oct 01, 2010

Free radicals enhance the activation of Antioxidant Response Element (ARE) by sulforaphane, despite suppression of Nrf2 nuclear accumulation.Jan 20, 2018

Sulforaphane attentuates cadmium-induced carcinogenesis through Nrf2, antioxidant, and autophagy mechanisms.Jan 15, 2018

Sulforaphane combats colon cancer in vitro by inhibiting COX-2 and prostaglandin E1 synthase and exhibiting anti-angiogenic, anti-proliferative, and anti-metastatic properties.Jan 01, 2018

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View the Evidence:
648 Abstracts with Broccoli Research