Bromelain

Name	AC	CK
Osteoarthritis: Knee	2	20
Inflammation	8	19
Wound Healing	4	14
Lung Cancer	2	12
Thrombosis	2	11
Breast Cancer	6	10
Cancers: All	5	10
Chemotherapy-Induced Toxicity: Peripheral Neuropathy	1	10
Constipation: Post-Operative	1	10
Dyspepsia	1	10
Edema	1	10
Oral Surgical Procedures	1	10
Osteoarthritis	1	10
Pain	1	10
Perineal trauma	1	10
Postoperative Edema	1	10
Postoperative Recovery	1	10
Prostatitis: Bacterial	1	10
Sinusitis	1	10
Tooth Extraction: Wisdom	1	10
Colorectal Cancer	3	8
Alzheimer's Disease	1	5
Cervical Cancer	1	5
Inflammatory Bowel Diseases	3	5
Allergic Airway Diseases	2	4
Asthma	2	4
Colitis	2	4
Coronavirus Infection	4	4
Neuropathic Pain	2	4
Tendon Injury	2	4
Skin Cancer	3	3
Aluminum Toxicity	1	2
Breastfeeding: Complications	1	2
Burns	1	2
Cancer Metastasis	1	2
Colon Cancer	1	2
Diabetic Complications	1	2
Gastric Cancer	2	2
Gastrointestinal Inflammation	1	2
Kidney Damage: Chemically-Induced	1	2
Lactation Disorders	1	2
Lead Poisoning	1	2
Lipopolysaccharide-Induced Toxicity	2	2
Liver Damage	1	2
Myocardial Infarction	1	2
Myocardial Ischemia	1	2
Non-Hodgkin Lymphoma	1	2
Obesity	1	2
Oxidative Stress	1	2
Rheumatoid Arthritis	1	2
Sciatic Nerve Crush Injury	1	2
Breast Cancer: Triple Negative	1	1
Cholangiocarcinoma	1	1
Cholera	1	1
Escherichia coli Infections	1	1
Glioma	1	1
Gram-Positive Bacterial Infections	1	1
Immune Disorders	1	1
Influenza	1	1
Intestinal Permeability	1	1
Leaky Gut Syndrome	1	1
Liver Cancer	1	1
Melanoma	1	1
Oral Cancer	1	1
Pancreatic Cancer	1	1
Periodontal Diseases	1	1
Prostate Cancer	1	1
Thrombophlebitis	1	1

Name	AC	CK
Anti-Inflammatory Agents	23	69
Analgesics	3	30
Anti-Bacterial Agents	4	22
Apoptotic	12	20
Anti-metastatic	4	14
Immunomodulatory	3	12
Malondialdehyde Down-regulation	2	12
Anti-Platelet	2	11
Antiproliferative	8	10
Chemoprotective Agents	1	10
Osteoprotective	1	10
Prostaglandin PGE2 downregulation	1	10
Neuroprotective Agents	3	9
Antineoplastic Agents	4	8
Antinoceceptive	3	6
Interleukin-10 downregulation	3	6
Antioxidants	3	5
NF-kappaB Inhibitor	5	5
Antiviral Agents	4	4
Cyclooxygenase 2 Inhibitors	4	4
Tumor Necrosis Factor (TNF) Alpha Inhibitor	3	4
Autophagy Up-regulation	2	3
Interleukin-1 beta downregulation	2	3
Interleukin-4 downregulation	2	3
Interleukin-6 Downregulation	2	3
Radiosensitizer	2	3
Anti-Adipogenic	1	2
Anti-Allergic Agents	1	2
Anti-Anxiety Agents	1	2
Anti-Asthmatic Agents	1	2
Anticarcinogenic Agents	2	2
Bcl-2 protein down-regulation	2	2
Cardioprotective	1	2
Chemosensitizer	2	2
Cytoprotective	1	2
Cytotoxic	2	2
Hepatoprotective	1	2
Immunostimulatory	2	2
Interferon Gamma Reducer	1	2
Interleukin-12 downregulation	1	2
Interleukin-17 downregulation	1	2
Postaglandin PGE2 downregulation	1	2
Radioprotective	1	2
Renoprotective	1	2
Tumor Suppressor Protein p53 Upregulation	2	2
Anti-thrombotic	1	1
Anticoagulants	1	1
Antifibrinolytic Agents	1	1
Antimicrobial	1	1
Cell cycle arrest	1	1
Chemopreventive	1	1
Chemotherapeutic	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1
Thrombolytic	1	1

[+]

A supplement with Ribes Nigrum, Boswellia Serrata, bromelain and vitamin D to stop local inflammation in chronic sinusitis.Apr 17, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Med. 2023 Apr 18 ;12(8). Epub 2023 Apr 18. PMID: 37109265

Article Published Date : Apr 17, 2023

Study Type : Human Study

Additional Links

Substances : Black Currant, Bromelain, Frankincense, Vitamin D

Diseases : Inflammation, Sinusitis

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Benefits of a food supplement containing Boswellia serrata and bromelain for improving the quality of life in patients with osteoarthritis.Oct 31, 2019

Click here to read the entire abstract

Pubmed Data : J Altern Complement Med. 2019 Nov 1. Epub 2019 Nov 1. PMID: 31674795

Article Published Date : Oct 31, 2019

Study Type : Human Study

Additional Links

Substances : Bromelain, Frankincense

Diseases : Osteoarthritis

Pharmacological Actions : Osteoprotective

[+]

Bromelain has anti-platelet properties.Feb 01, 2006

Click here to read the entire abstract

Pubmed Data : Platelets. 2006 Feb;17(1):37-41. PMID: 16308185

Article Published Date : Feb 01, 2006

Study Type : Human Study

Additional Links

Substances : Bromelain

Diseases : Thrombosis

Pharmacological Actions : Anti-Platelet

[+]

Bromelain has antimetastic protential as demonstrated in lung cancer cells - Article 1. Jan 01, 1988

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Pubmed Data : J Cancer Res Clin Oncol. 1988;114(5):507-8. PMID: 3182910

Article Published Date : Jan 01, 1988

Study Type : Human Study

Additional Links

Substances : Bromelain, Pineapple

Diseases : Lung Cancer

Pharmacological Actions : Anti-metastatic

[+]

Bromelain has no difference in reducing symptoms of mild-to-moderate knee OA after 4 weeks when compared with diclofenac.Sep 30, 2016

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Pubmed Data : Clin Rheumatol. 2016 Oct ;35(10):2531-40. Epub 2016 Jul 28. PMID: 27470088

Article Published Date : Sep 30, 2016

Study Type : Human Study

Additional Links

Substances : Bromelain

Diseases : Osteoarthritis: Knee

Pharmacological Actions : Anti-Inflammatory Agents, Malondialdehyde Down-regulation, Prostaglandin PGE2 downregulation

Problem Substances : Diclofenac

[+]

Bromelain is effective in treating postoperative edema after third molar surgery.Sep 01, 2010

Click here to read the entire abstract

Pubmed Data : Eur Rev Med Pharmacol Sci. 2010 Sep;14(9):771-4. PMID: 21061836

Article Published Date : Sep 01, 2010

Study Type : Human Study

Additional Links

Substances : Bromelain

Diseases : Edema, Oral Surgical Procedures, Postoperative Edema, Postoperative Recovery

Pharmacological Actions : Analgesics, Anti-Bacterial Agents, Anti-Inflammatory Agents

Additional Keywords : Dental

[+]

Bromelain may benefit children diagnosed with acute sinusitis. Mar 01, 2005

Click here to read the entire abstract

Pubmed Data : In Vivo. 2005 Mar-Apr;19(2):417-21. PMID: 15796206

Article Published Date : Mar 01, 2005

Study Type : Human Study

Additional Links

Substances : Bromelain

Diseases : Sinusitis

[+]

Bromelain may benefit patients with postoperative constipation. Sep 01, 2007

Click here to read the entire abstract

Pubmed Data : Pharmacol Res. 2007 Sep;56(3):254-60. Epub 2007 Jul 14. PMID: 16137711

Article Published Date : Sep 01, 2007

Study Type : Human Study

Additional Links

Substances : Bromelain

Diseases : Constipation: Post-Operative

[+]

Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults.Dec 01, 2002

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2002 Dec;9(8):681-6. PMID: 12587686

Article Published Date : Dec 01, 2002

Study Type : Human Study

Additional Links

Substances : Bromelain

Diseases : Osteoarthritis: Knee

Pharmacological Actions : Analgesics

[+]

OPERA was able to improve CIPN symptoms in a prospective series of patients treated with neurotoxic chemotherapy.Feb 28, 2017

Click here to read the entire abstract

Pubmed Data : Med Oncol. 2017 Mar ;34(3):46. Epub 2017 Feb 15. PMID: 28205185

Article Published Date : Feb 28, 2017

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid, Bromelain

Diseases : Chemotherapy-Induced Toxicity: Peripheral Neuropathy

Pharmacological Actions : Chemoprotective Agents

[+]

Sodium alginate, sodium bicarbonate, bromelain and essential oils have therapeutic value in the treatment of functional dyspepsia.Jun 01, 2009

Click here to read the entire abstract

Pubmed Data : Clin Exp Allergy. 2009 Jun;39(6):875-82. PMID: 19829282

Article Published Date : Jun 01, 2009

Study Type : Human Study

Additional Links

Substances : Bromelain, Essential Oils: Unspecified, Sodium Alginate, Sodium Bicarbonate

Diseases : Dyspepsia

[+]

The combination of serenoa repens, selenium, lycopene and bromelain are beneficial in patients with chronic bacterial prostatitis.Oct 04, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Arch Ital Urol Androl. 2016 Oct 5 ;88(3):177-182. Epub 2016 Oct 5. PMID: 27711089

Article Published Date : Oct 04, 2016

Study Type : Human Study

Additional Links

Substances : Bromelain, Lycopene, Saw Palmetto, Selenium

Diseases : Prostatitis: Bacterial

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

[+]

These results showed the effectiveness of bromelain on episiotomy pain and wound healing.Feb 29, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran Red Crescent Med J. 2016 Mar ;18(3):e21019. Epub 2016 Mar 1. PMID: 27247780

Article Published Date : Feb 29, 2016

Study Type : Human Study

Additional Links

Substances : Bromelain, Pineapple

Diseases : Pain, Perineal trauma , Wound Healing

Pharmacological Actions : Analgesics

[+]

This study thus clearly supports the clinical relevance of treatment of postoperative conditions with bromelain.Sep 05, 2016

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2016 Sep 6. Epub 2016 Sep 6. PMID: 27601419

Article Published Date : Sep 05, 2016

Study Type : Human Study

Additional Links

Substances : Bromelain

Diseases : Tooth Extraction: Wisdom

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Treatment of COVID-19 patients with quercetin: a prospective, single center, randomized, controlled trial.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Turk J Biol. 2021 ;45(4):518-529. Epub 2021 Aug 30. PMID: 34803451

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : Bromelain, Quercetin, Vitamin C

Diseases : Coronavirus Infection

[+]

Anti-cancer activity of bromelain nanoparticles by oral administration.Nov 30, 2014

Click here to read the entire abstract

Pubmed Data : J Biomed Nanotechnol. 2014 Dec ;10(12):3558-75. PMID: 26000370

Article Published Date : Nov 30, 2014

Study Type : Human In Vitro

Additional Links

Substances : Bromelain

Diseases : Breast Cancer, Cancers: All, Cervical Cancer, Colorectal Cancer

Pharmacological Actions : Antineoplastic Agents, Apoptotic

[+]

Bromelain degrades Aβ1-42 monomers and soluble aggregates.Jan 22, 2018

Click here to read the entire abstract

Pubmed Data : Curr Alzheimer Res. 2018 Jan 23. Epub 2018 Jan 23. PMID: 29359669

Article Published Date : Jan 22, 2018

Study Type : Human In Vitro

Additional Links

Substances : Bromelain

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Bromelain extract exerts antiarthritic effects via chondroprotection.Oct 22, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Plants (Basel). 2021 Oct 23 ;10(11). Epub 2021 Oct 23. PMID: 34834636

Article Published Date : Oct 22, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Inflammation, Osteoarthritis, Rheumatoid Arthritis

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Chondroprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Bromelain mitigates liver fibrosis via targeting hepatic stellate cells.May 31, 2023

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Pubmed Data : Tissue Cell. 2023 Jun ;82:102118. Epub 2023 May 27. PMID: 37269556

Article Published Date : May 31, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Liver Cirrhosis, Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective

[+]

Addition of bromelain and acetylcysteine to gemcitabine potentiates tumor inhibition in vivo in human colon cancer cell line LS174T.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Cancer Res. 2021 ;11(5):2252-2263. Epub 2021 May 15. PMID: 34094682

Article Published Date : Dec 31, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Bromelain, Cysteine (see N-Acetylcysteine)

Diseases : Colon Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Gemcitabine

[+]

Ameliorative effects of bromelain on aluminum-induced Alzheimer's disease.Jan 31, 2023

Click here to read the entire abstract

Pubmed Data : Int J Biol Macromol. 2023 Feb 1 ;227:1119-1131. Epub 2022 Dec 1. PMID: 36462588

Article Published Date : Jan 31, 2023

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Aluminum

[+]

Antinociceptive and neuroprotective effects of bromelain in chronic constriction injury-induced neuropathic pain.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Korean J Pain. 2020 Jan 1 ;33(1):13-22. PMID: 31888313

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Neuropathic Pain

Pharmacological Actions : Antinoceceptive , Neuroprotective Agents

[+]

Bromelain Ameliorates Atherosclerosis.Dec 28, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2022 Dec 29 ;12(1). Epub 2022 Dec 29. PMID: 36670934

Article Published Date : Dec 28, 2022

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Atherosclerosis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hypolipidemic

[+]

Bromelain ameliorates D-galactosamine-induced acute liver injury.Nov 24, 2022

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Pubmed Data : J Pharm Pharmacol. 2022 Nov 25 ;74(12):1765-1775. PMID: 36227279

Article Published Date : Nov 24, 2022

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Bromelain ameliorates hepatic microcirculation after warm ischemia indicating it may have liver protective effects after injury. May 01, 2007

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Pubmed Data : J Surg Res. 2007 May 1;139(1):88-96. Epub 2007 Feb 8. PMID: 17292418

Article Published Date : May 01, 2007

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Bromelain and acetylcysteine alone and in combination with gemcitabine inhibit subcutaneous deposits of pancreatic cancer after intraperitoneal injection.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Transl Res. 2021 ;13(12):13524-13539. Epub 2021 Dec 15. PMID: 35035694

Article Published Date : Dec 31, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Bromelain, NAC (N-acetyl-L-cysteine)

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Chemotherapeutic Synergy: Gemcitabine

[+]

Bromelain and fresh pineapple juice have a therapeutic effect in acute crush archilles tendon injury.Apr 01, 2011

Click here to read the entire abstract

Pubmed Data : J Med Food. 2011 Apr;14(4):348-52. Epub 2011 Jan 23. PMID: 21254908

Article Published Date : Apr 01, 2011

Study Type : Animal Study

Additional Links

Substances : Bromelain, Pineapple

Diseases : Tendon Injury

[+]

Bromelain attenuates inflammation in an experimental mouse model of asthma. Mar 01, 2008

Click here to read the entire abstract

Pubmed Data : Evid Based Complement Alternat Med. 2008 Mar;5(1):61-9. PMID: 18317550

Article Published Date : Mar 01, 2008

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Asthma

Pharmacological Actions : Anti-Asthmatic Agents

[+]

Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease.Sep 01, 2005

Click here to read the entire abstract

Pubmed Data : Cell Immunol. 2005 Sep;237(1):68-75. Epub 2005 Dec 6. PMID: 16337164

Article Published Date : Sep 01, 2005

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Allergic Airway Diseases

Pharmacological Actions : Anti-Allergic Agents, Anti-Inflammatory Agents

[+]

Bromelain has a healing effect in acute crush Archilles tendon injury. Jan 01, 2009

Click here to read the entire abstract

Pubmed Data : Ann Nutr Metab. 2009;54(4):283-90. Epub 2009 Jul 27. PMID: 20623610

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Tendon Injury

[+]

Bromelain has a therapeutic effect in established allergic airway disease.Aug 31, 2012

Click here to read the entire abstract

Pubmed Data : Altern Ther Health Med. 2012 Sep-Oct;18(5):9-17. PMID: 22894886

Article Published Date : Aug 31, 2012

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Allergic Airway Diseases, Asthma

Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-12 downregulation, Interleukin-17 downregulation, Interleukin-4 downregulation

[+]

Bromelain has cardioprotective properties against an experimental model of heart injury. Mar 01, 2008

Click here to read the entire abstract

Pubmed Data : Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1365-70. Epub 2008 Jan 11. PMID: 18192224

Article Published Date : Mar 01, 2008

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Myocardial Infarction, Myocardial Ischemia

Pharmacological Actions : Apoptotic, Cardioprotective

[+]

Bromelain has immunomodulatory properties. Dec 20, 2006

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2006 Dec 20;6(13-14):2038-46. Epub 2006 Sep 5. PMID: 17161360

Article Published Date : Dec 20, 2006

Study Type : Animal Study

Additional Links

Substances : Bromelain

Pharmacological Actions : Interleukin-10 downregulation

[+]

Bromelain has the potential to reduce the side effects of BPA on the male reproductive system.Nov 30, 2022

Click here to read the entire abstract

Pubmed Data : Andrologia. 2022 Dec ;54(11):e14584. Epub 2022 Sep 6. PMID: 36068179

Article Published Date : Nov 30, 2022

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Bisphenol Toxicity, Oxidative Stress, Sperm Quality: Low

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation

Additional Keywords : Estrogen Receptor Beta

Problem Substances : Bisphenol A

[+]

Bromelain increases milk yield, milk composition and has no adverse effects on mammary health in dairy goats.Apr 01, 2009

Click here to read the entire abstract

Pubmed Data : Trop Anim Health Prod. 2009 Apr;41(4):493-8. Epub 2008 Jul 27. PMID: 18661260

Article Published Date : Apr 01, 2009

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Breastfeeding: Complications, Lactation Disorders

[+]

Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2019 ;14(1):e0210274. Epub 2019 Jan 18. PMID: 30657763

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation

[+]

Bromelain loaded nano lipid carriers opens new avenue for development of novel effective therapeutic modality for rheumatoid arthritis management.Jan 31, 2021

Click here to read the entire abstract

Pubmed Data : Int J Pharm. 2021 Feb 1 ;594:120176. Epub 2020 Dec 14. PMID: 33326825

Article Published Date : Jan 31, 2021

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Bromelain may be an option in periodontal therapy by regulating cytokine levels, improving the healing process, and reducing bone resorption.Jul 31, 2023

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2023 Aug ;121:110446. Epub 2023 Jun 7. PMID: 37290321

Article Published Date : Jul 31, 2023

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Periodontitis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Bromelain mitigated electrolyte imbalance in chronic constricted injury of the sciatic nerve.Oct 25, 2019

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Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 Oct 26. Epub 2019 Oct 26. PMID: 31655851

Article Published Date : Oct 25, 2019

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Sciatic Nerve Crush Injury

Pharmacological Actions : Antinoceceptive

[+]

Bromelain modulates liver injury, hematological, molecular, and biochemical perturbations induced by aluminum.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Res Int. 2022 ;2022:5342559. Epub 2022 Nov 21. PMID: 36452063

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Aluminum Toxicity , Chemically-Induced Liver Damage, Inflammation, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Aluminum

[+]

Bromelain plus peroxidase reduces non-Hodgkin lymphoma progressionOct 07, 2019

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2019 Oct 8:1-11. Epub 2019 Oct 8. PMID: 31591915

Article Published Date : Oct 07, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Bromelain, Pineapple

Diseases : Non-Hodgkin Lymphoma

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Bromelain protects against cisplatin-induced ocular toxicity through mitigating oxidative stress and inflammation.Dec 12, 2021

Click here to read the entire abstract

Pubmed Data : Drug Chem Toxicol. 2021 Dec 13:1-8. Epub 2021 Dec 13. PMID: 34894956

Article Published Date : Dec 12, 2021

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents

[+]

Bromelain reduced pro-inflammatory mediators as a common pathway that mediate antinociceptive and anti-anxiety effects in a sciatic nerve ligation model.Jan 10, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2021 Jan 11 ;11(1):289. Epub 2021 Jan 11. PMID: 33432004

Article Published Date : Jan 10, 2021

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Neuropathic Pain

Pharmacological Actions : Anti-Anxiety Agents, Antinoceceptive , Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Bromelain represents a novel approach to the treatment of metal toxicity.May 31, 2015

Click here to read the entire abstract

Pubmed Data : Acta Biol Hung. 2015 Jun ;66(2):149-60. PMID: 26081271

Article Published Date : May 31, 2015

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Lead Poisoning

Pharmacological Actions : Cytoprotective, Malondialdehyde Down-regulation

Problem Substances : Lead

[+]

Bromelain treatment decreases neutrophil migration to sites of inflammation.Jul 01, 2008

Click here to read the entire abstract

Pubmed Data : Clin Immunol. 2008 Jul;128(1):66-74. Epub 2008 May 14. PMID: 18482869

Article Published Date : Jul 01, 2008

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in mice with colitis.Dec 01, 2010

Click here to read the entire abstract

Pubmed Data : Inflamm Bowel Dis. 2010 Dec;16(12):2012-21. PMID: 20848493

Article Published Date : Dec 01, 2010

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Colitis, Colon Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation

[+]

Effect of bromelain on mast cell numbers and degranulation in diabetic rat wound healing.Jul 31, 2022

Click here to read the entire abstract

Pubmed Data : J Wound Care. 2022 Aug 1 ;31(Sup8):S4-S11. PMID: 36004940

Article Published Date : Jul 31, 2022

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Diabetic Complications, Wound Healing

[+]

Enhancement of the anti-inflammatory effect of bromelain by its immobilization on probiotic spore of Bacillus cereus.Nov 05, 2020

Click here to read the entire abstract

Pubmed Data : Probiotics Antimicrob Proteins. 2020 Nov 6. Epub 2020 Nov 6. PMID: 33156496

Article Published Date : Nov 05, 2020

Study Type : Animal Study

Additional Links

Substances : Bromelain, Probiotics

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Nephroprotective role of bromelain against oxidative injury induced by aluminium.Oct 31, 2020

Click here to read the entire abstract

Pubmed Data : Environ Toxicol Pharmacol. 2020 Nov ;80:103509. Epub 2020 Oct 1. PMID: 33010469

Article Published Date : Oct 31, 2020

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Aluminum Toxicity , Kidney Damage: Chemically-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Renoprotective

Problem Substances : Aluminum

[+]

Pharmacological evaluation of bromelain in mouse model of Alzheimer's disease.Dec 31, 2021

Click here to read the entire abstract

Pubmed Data : Neurotoxicology. 2022 05 ;90:19-34. Epub 2022 Feb 24. PMID: 35219781

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Pineapple bromelain has anti-tumor properties superior to the chemo-agent 5-fluorouracil.Oct 01, 2007

Click here to read the entire abstract

Pubmed Data : Planta Med. 2007 Oct;73(13):1377-83. Epub 2007 Sep 24. PMID: 17893836

Article Published Date : Oct 01, 2007

Study Type : Animal Study

Additional Links

Substances : Bromelain, Pineapple

Diseases : Cancer Metastasis, Lung Cancer

Pharmacological Actions : Anti-metastatic

Additional Keywords : Drug: 5-flourouracil, Food as Medicine, Hall of Fame, Superiority of Natural Substances versus Drugs

[+]

Protective effect of bromelain on corrosive burns.Dec 09, 2020

Click here to read the entire abstract

Pubmed Data : Burns. 2020 Dec 10. Epub 2020 Dec 10. PMID: 33934907

Article Published Date : Dec 09, 2020

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Burns

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Protective effects of bromelain against cadmium-induced pulmonary intoxication.Jan 10, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Arch Razi Inst. 2021 11 ;76(5):1427-1436. Epub 2021 Nov 30. PMID: 35355740

Article Published Date : Jan 10, 2021

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Cadmium Poisoning

Pharmacological Actions : Anti-Inflammatory Agents

Problem Substances : Cadmium

[+]

Protein stem bromelain together with all-trans retinoic-acid (atRA), may be a potent modulator of obesity by repressing the PPARγ-regulated adipogenesis pathwayDec 31, 2011

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2012 ;7(1):e30831. Epub 2012 Jan 24. PMID: 22292054

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Obesity

Pharmacological Actions : Anti-Adipogenic, Apoptotic

Additional Keywords : Anti-Obesity Agents

[+]

Study of the radiosensitizing and radioprotective efficacy of bromelain.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Integr Cancer Ther. 2020 Jan-Dec;19:1534735420950468. PMID: 32783540

Article Published Date : Dec 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Cancers: All

Pharmacological Actions : Radioprotective, Radiosensitizer

[+]

The ameliorative effect of bromelain on STZ-induced type 1 diabetes.Nov 14, 2021

Click here to read the entire abstract

Pubmed Data : Life Sci. 2021 Nov 15 ;285:119982. Epub 2021 Sep 27. PMID: 34592232

Article Published Date : Nov 14, 2021

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Diabetes Mellitus: Type 1

Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Malondialdehyde Down-regulation

[+]

The present study provides new insights into the potential therapeutic value of bromelain for the prevention and treatment of thrombosis-related diseases.May 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Jun 1 ;14(11). Epub 2022 Jun 1. PMID: 35684129

Article Published Date : May 31, 2022

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Nonalcoholic fatty liver disease (NAFLD), Thrombosis

Pharmacological Actions : Anticoagulants, Hepatoprotective

[+]

Therapeutic effect of bromelain and papain on intestinal injury induced by indomethacin.Dec 31, 2022

Click here to read the entire abstract

Pubmed Data : Int J Health Sci (Qassim). 2023 ;17(5):23-30. PMID: 37692988

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Bromelain, Papain

Diseases : Drug-Induced Toxicity: Indomethacin

Pharmacological Actions : Gastroprotective

Problem Substances : Indomethacin

[+]

These results supply novel insights into potential inflammatory bowel disease treatment by purified fruit bromelain.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Front Immunol. 2017 ;8:1468. Epub 2017 Nov 10. PMID: 29176974

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Gastrointestinal Inflammation, Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease.Aug 01, 2005

Click here to read the entire abstract

Pubmed Data : Clin Immunol. 2005 Aug;116(2):135-42. PMID: 15936249

Article Published Date : Aug 01, 2005

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Colitis, Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation

[+]

Use of bromelain in cutaneous wound healing in streptozocin-induced diabetes.Sep 01, 2020

Click here to read the entire abstract

Pubmed Data : J Wound Care. 2020 Sep 2 ;29(9):488-495. PMID: 32924815

Article Published Date : Sep 01, 2020

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Diabetic Complications, Wound Healing

Pharmacological Actions : Anti-Inflammatory Agents

[+]

The Combination ofBromelain and acetylcysteine (BromAc) synergistically inactivates SARS-CoV-2.Jan 05, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Viruses. 2021 03 6 ;13(3). Epub 2021 Mar 6. PMID: 33800932

Article Published Date : Jan 05, 2021

Study Type : In Vitro Study

Additional Links

Substances : Bromelain, NAC (N-acetyl-L-cysteine)

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

[+]

"Bromelain: biochemistry, pharmacology and medical use."Jul 31, 2001

Click here to read the entire abstract

Pubmed Data : Cell Mol Life Sci. 2001 Aug ;58(9):1234-45. PMID: 11577981

Article Published Date : Jul 31, 2001

Study Type : Review

Additional Links

Substances : Bromelain

Diseases : Thrombophlebitis

Additional Keywords : Phytotherapy

[+]

Anti-cancer effect of bromelain and its combination with cisplatin on HN5 cell line.Aug 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Dent (Shiraz). 2022 Sep ;23(3):257-265. PMID: 36506883

Article Published Date : Aug 31, 2022

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Chemoprotective Agents

[+]

Anti-inflammatory and mineralization effects of bromelain on lipopolysaccharide-induced inflammation.Jun 07, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Medicina (Kaunas). 2021 Jun 8 ;57(6). Epub 2021 Jun 8. PMID: 34201357

Article Published Date : Jun 07, 2021

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

[+]

Anti-inflammatory effect of pineapple rhizome bromelain.May 06, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Curr Issues Mol Biol. 2021 May 7 ;43(1):93-106. Epub 2021 May 7. PMID: 34067064

Article Published Date : May 06, 2021

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

Anti-inflammatory properties of a proprietary bromelain extract.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211034686. PMID: 34387509

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Inflammation, Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Bromelain a potential bioactive compound: A comprehensive overview.Apr 05, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Life (Basel). 2021 Apr 6 ;11(4). Epub 2021 Apr 6. PMID: 33917319

Article Published Date : Apr 05, 2021

Study Type : Review

Additional Links

Substances : Bromelain

Diseases : Arthritis, Digestive System Diseases, Respiratory Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Antimicrobial, Immunomodulatory

[+]

Bromelain and NAC inhibit the growth, proliferation and survival of human gastrointestinal cancer cells.Nov 11, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Exp Clin Cancer Res. 2014 Nov 12 ;33:92. Epub 2014 Nov 12. PMID: 25425315

Article Published Date : Nov 11, 2014

Study Type : In Vitro Study

Additional Links

Substances : Bromelain, NAC (N-acetyl-L-cysteine)

Diseases : Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Natural Substance Synergy

[+]

Bromelain and Olea europaea (L.) leaf extract mediated alleviation of benzo(a)pyrene induced lung cancer.Apr 22, 2021

Click here to read the entire abstract

Pubmed Data : Environ Sci Pollut Res Int. 2021 Apr 23. Epub 2021 Apr 23. PMID: 33893581

Article Published Date : Apr 22, 2021

Study Type : In Vitro Study

Additional Links

Substances : Bromelain, Olive leaf extract

Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

Additional Keywords : Natural Substance Synergy

Problem Substances : Benzo(a)pyrene

[+]

Bromelain and papain exhibit anti-flu virion properties.May 01, 2008

Click here to read the entire abstract

Pubmed Data : Bioorg Khim. 2008 May-Jun;34(3):409-15. PMID: 18672693

Article Published Date : May 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Bromelain, Papain

Diseases : Influenza

Pharmacological Actions : Antiviral Agents

[+]

Bromelain and papain have cytotoxic effects on human cholangiocarcinoma cell lines.Apr 30, 2016

Click here to read the entire abstract

Pubmed Data : Int J Oncol. 2016 May ;48(5):2025-34. Epub 2016 Mar 1. PMID: 26935541

Article Published Date : Apr 30, 2016

Study Type : In Vitro Study

Additional Links

Substances : Bromelain, Papain

Diseases : Cholangiocarcinoma

Pharmacological Actions : Anti-Inflammatory Agents, Cytotoxic, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor

[+]

Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Anim Cells Syst (Seoul). 2018 ;22(5):334-340. Epub 2018 Aug 30. PMID: 30460115

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Cytotoxic

[+]

Bromelain enhances intestinal absorption and/or permeability. Jan 24, 2005

Click here to read the entire abstract

Pubmed Data : Arch Intern Med. 2005 Jan 24;165(2):200-6. PMID: 16950580

Article Published Date : Jan 24, 2005

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Intestinal Permeability , Leaky Gut Syndrome

[+]

Bromelain exerts an antibacterial effect against potent periodontal pathogens.Aug 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Int Oral Health. 2014 Sep ;6(5):96-8. PMID: 25395802

Article Published Date : Aug 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Bromelain, Pineapple

Diseases : Periodontal Diseases

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Plant Extracts

[+]

Bromelain exerts anti-inflammatory activity by modulating activated CD4(+) cells. Mar 01, 2009

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2009 Mar;9(3):340-6. Epub 2009 Jan 20. PMID: 19162239

Article Published Date : Mar 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Bromelain exhibits anti-skin cancer and anti-melanoma activity. Mar 22, 2011

Click here to read the entire abstract

Pubmed Data : Mol Carcinog. 2011 Mar 22. Epub 2011 Mar 22. PMID: 21432909

Article Published Date : Mar 22, 2011

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Melanoma, Skin Cancer

Pharmacological Actions : Apoptotic, Cell cycle arrest, NF-kappaB Inhibitor

[+]

Bromelain has anti-tumor initiating activity against skin cancer cells.Sep 18, 2009

Click here to read the entire abstract

Pubmed Data : Cancer Lett. 2009 Sep 18;282(2):167-76. Epub 2009 Mar 31. PMID: 19339108

Article Published Date : Sep 18, 2009

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Skin Cancer

Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation

[+]

Bromelain has inhibitory effects on colony formation in cancer cells.Sep 30, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Med Signals Sens. 2019 Oct-Dec;9(4):267-273. Epub 2019 Oct 24. PMID: 31737556

Article Published Date : Sep 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Breast Cancer, Gastric Cancer, Prostate Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative

[+]

Bromelain in combination with cisplatin synergistically enhanced the induction of apoptosis in MDA-MB-231 cells.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Chin Med. 2016 ;11:46. Epub 2016 Nov 15. PMID: 27891174

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Apoptotic, Chemosensitizer, Chemotherapeutic

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

Bromelain induces apoptosis-related cell death in breast cancer cells with increasing concentrations in vitro.Apr 01, 2012

Click here to read the entire abstract

Pubmed Data : J Med Food. 2012 Apr ;15(4):344-9. Epub 2011 Dec 22. PMID: 22191568

Article Published Date : Apr 01, 2012

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic

Additional Keywords : Antitumorigenic, Apoptosis, Breast Cancer, Bromelain

Anti Therapeutic Actions : Nocebo Effect

[+]

Bromelain inhibits invasive properties of glioma cells. Nov 01, 2001

Click here to read the entire abstract

Pubmed Data : Neoplasia. 2001 Nov-Dec;3(6):469-79. PMID: 11774029

Article Published Date : Nov 01, 2001

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Glioma

[+]

Bromelain inhibits lipopolysaccharide-induced inflammation. Jan 01, 2003

Click here to read the entire abstract

Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2003;23(2):151-3. PMID: 18569070

Article Published Date : Jan 01, 2003

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Bromelain inhibits SARS-CoV-2 infection in VeroE6 cells.Sep 15, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : bioRxiv. 2020 Sep 16. Epub 2020 Sep 16. PMID: 32995771

Article Published Date : Sep 15, 2020

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

[+]

Bromelain may have anti-skin tumor activity. Jan 01, 2008

Click here to read the entire abstract

Pubmed Data : Toxicol Appl Pharmacol. 2008 Jan 1;226(1):30-7. Epub 2007 Aug 23. PMID: 17889918

Article Published Date : Jan 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Skin Cancer

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation

[+]

Bromelain may have therapeutic value in the treatment of irritable bowel syndrome. Mar 01, 2008

Click here to read the entire abstract

Pubmed Data : Clin Immunol. 2008 Mar;126(3):345-52. Epub 2007 Dec 21. PMID: 18160345

Article Published Date : Mar 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Bromelain may stimulate type 1 cells up-regulating both innate as well as the adaptive immune system.Aug 17, 2005

Click here to read the entire abstract

Pubmed Data : Eur J Med Res. 2005 Aug 17;10(8):325-31. PMID: 16131473

Article Published Date : Aug 17, 2005

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Immune Disorders

Pharmacological Actions : Antiproliferative , Immunostimulatory

[+]

Bromelain reduces platelet aggregation and inhibits thrombus formation.Jan 01, 1999

Click here to read the entire abstract

Pubmed Data : In Vivo. 1999 Jan-Feb;13(1):7-12. PMID: 10218125

Article Published Date : Jan 01, 1999

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Thrombosis

Pharmacological Actions : Anti-Platelet, Thrombolytic

[+]

Bromelain supplementation and inflammatory markers.May 31, 2023

Click here to read the entire abstract

Pubmed Data : Clin Nutr ESPEN. 2023 Jun ;55:116-127. Epub 2023 Mar 2. PMID: 37202035

Article Published Date : May 31, 2023

Study Type : Review

Additional Links

Substances : Bromelain

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Bromelain treatment could potentiate the antitumor effect of cisplatin on triple-negative breast cancer 4T1 cells.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Integr Cancer Ther. 2019 Jan-Dec;18:1534735419880258. PMID: 31752555

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Breast Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-4 downregulation

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

Bromelain-cisplatin chemoherbal combination demonstrated synergistic in-vitro anticancer effect on human prostatic carcinoma cell line.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Galen Med J. 2020 ;9:e1749. Epub 2020 Aug 29. PMID: 34466585

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Prostate Cancer

Pharmacological Actions : Apoptotic, Chemosensitizer

[+]

Bromelain: a review of its mechanisms, pharmacological effects and potential applications.Aug 30, 2023

Click here to read the entire abstract

Pubmed Data : Food Funct. 2023 Aug 31. Epub 2023 Aug 31. PMID: 37650738

Article Published Date : Aug 30, 2023

Study Type : Review

Additional Links

Substances : Bromelain

Diseases : Asthma, Inflammation, Osteoarthritis, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Bromelain: A review on its potential as a therapy for the management of Covid-19.Jan 29, 2020

Click here to read the entire abstract

Pubmed Data : Niger J Physiol Sci. 2020 06 30 ;35(1):10-19. Epub 2020 Jun 30. PMID: 33084621

Article Published Date : Jan 29, 2020

Study Type : Review

Additional Links

Substances : Bromelain

Diseases : Coronavirus Infection

Pharmacological Actions : Anti-Inflammatory Agents, Anticoagulants

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Cross-linked bromelain inhibits lipopolysaccharide-induced inflammation. Mar 22, 2006

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2006 Mar 22;54(6):2193-8. PMID: 16536595

Article Published Date : Mar 22, 2006

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors

[+]

Cytotoxic effect of bromelain on HepG2 hepatocellular carcinoma cell line. Mar 17, 2021

Click here to read the entire abstract

Pubmed Data : Appl Biochem Biotechnol. 2021 Mar 18. Epub 2021 Mar 18. PMID: 33735410

Article Published Date : Mar 17, 2021

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic

[+]

Enhancing the potency of chemotherapeutic agents by combination with bromelain and N-acetylcysteine.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Transl Res. 2020 ;12(11):7404-7419. Epub 2020 Nov 15. PMID: 33312377

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Bromelain, NAC (N-acetyl-L-cysteine)

Diseases : Liver Cancer, Pancreatic Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Doxorubicin, Chemotherapeutic Synergy: Gemcitabine

[+]

Evaluation of the radiosensitizing potency of bromelain for radiation therapy of 4T1 breast cancer cells.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Med Signals Sens. 2019 Jan-Mar;9(1):68-74. PMID: 30967992

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Radiosensitizer

[+]

Herbal anti-inflammatory agents for skin disease.Jan 01, 2000

Click here to read the entire abstract

Pubmed Data : Skin Therapy Lett. 2000 ;5(4):3-5. PMID: 10785407

Article Published Date : Jan 01, 2000

Study Type : Review

Additional Links

Substances : Bromelain, Capsaicin, Turmeric

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Naturally occurring immunomodulators with antitumor activity.Aug 31, 2017

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2017 Sep ;50:291-304. PMID: 28734166

Article Published Date : Aug 31, 2017

Study Type : Review

Additional Links

Substances : Betulinic acid, Bromelain, Curcumin, Genistein, Resveratrol, Zerumbone

Diseases : Cancers: All

Pharmacological Actions : Antineoplastic Agents, Immunomodulatory

[+]

Neuroprotective effect of bromelain in 6-hydroxydopamine induced in vitro model of Parkinson's disease.Nov 30, 2021

Click here to read the entire abstract

Pubmed Data : Mol Biol Rep. 2021 Dec ;48(12):7711-7717. Epub 2021 Oct 13. PMID: 34643923

Article Published Date : Nov 30, 2021

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Parkinson's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Papain and bromelain have an antibacterial effect on A. acidoterrestris.Jan 03, 2016

Click here to read the entire abstract

Pubmed Data : Int J Food Microbiol. 2016 Jan 4 ;216:121-6. Epub 2015 Oct 8. PMID: 26476327

Article Published Date : Jan 03, 2016

Study Type : In Vitro Study

Additional Links

Substances : Bromelain, Papain

Diseases : Gram-Positive Bacterial Infections

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance Synergy

[+]

Pineapple bromelain induces apoptosis in mammary cancer cells.Sep 16, 2010

Click here to read the entire abstract

Pubmed Data : Biofactors. 2010 Sep 16. Epub 2010 Sep 16. PMID: 20848558

Article Published Date : Sep 16, 2010

Study Type : In Vitro Study

Additional Links

Substances : Bromelain, Pineapple

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic, Autophagy Up-regulation

Additional Keywords : Autophagy

[+]

Radiosensitizing effect of bromelain.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Integr Cancer Ther. 2021 Jan-Dec;20:15347354211060369. PMID: 34825602

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Cancers: All

Pharmacological Actions : NF-kappaB Inhibitor, Radiosensitizer

[+]

Results demonstrate that bacterial nanocellulose could improve bromelain antimicrobial activity 9 times.Dec 20, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2017 Dec 21 ;7(1):18031. Epub 2017 Dec 21. PMID: 29269741

Article Published Date : Dec 20, 2017

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Pharmacological Actions : Antimicrobial, Antioxidants

[+]

Review: Bromelain's anti-cancer potential. Apr 28, 2010

Click here to read the entire abstract

Pubmed Data : Cancer Lett. 2010 Apr 28;290(2):148-56. Epub 2009 Aug 22. PMID: 19700238

Article Published Date : Apr 28, 2010

Study Type : Review

Additional Links

Substances : Bromelain

Diseases : Cancers: All

Pharmacological Actions : Antineoplastic Agents

[+]

The benefit of combining curcumin, bromelain and harpagophytum to reduce inflammation in osteoarthritic synovial cells.Oct 13, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Med Ther. 2021 Oct 14 ;21(1):261. Epub 2021 Oct 14. PMID: 34649531

Article Published Date : Oct 13, 2021

Study Type : In Vitro Study

Additional Links

Substances : Bromelain, Curcumin

Diseases : Inflammation, Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Plant Extracts

[+]

The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19.Nov 30, 2020

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Pubmed Data : Metabol Open. 2020 Dec ;8:100066. Epub 2020 Nov 13. PMID: 33205039

Article Published Date : Nov 30, 2020

Study Type : In Vitro Study

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Substances : Bromelain, Curcumin

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents, Immunostimulatory

Additional Keywords : Natural Substance Synergy

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The combination of bromelain and dexamethasone sodium phosphate induced a great activation of mesenchymal stem cells.May 31, 2019

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Pubmed Data : J Craniofac Surg. 2019 Jun ;30(4):1064-1067. PMID: 30358745

Article Published Date : May 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Wound Healing

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Mesenchymal Stem Cells, Natural Substance/Drug Synergy

Problem Substances : Dexamethasone

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The current review describes the promising clinical applications and therapeutic properties of bromelain.Aug 31, 2016

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Pubmed Data : Biomed Rep. 2016 Sep ;5(3):283-288. Epub 2016 Jul 18. PMID: 27602208

Article Published Date : Aug 31, 2016

Study Type : Review

Additional Links

Substances : Bromelain

Diseases : Cancers: All, Cholera, Escherichia coli Infections, Inflammation, Wound Healing

Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Anti-thrombotic, Antifibrinolytic Agents, Chemopreventive, Immunomodulatory

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The potential use of bromelain as a natural oral medicine having anticarcinogenic activities.Apr 30, 2019

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Pubmed Data : Food Sci Nutr. 2019 May ;7(5):1656-1667. Epub 2019 Apr 1. PMID: 31139378

Article Published Date : Apr 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Oral Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative

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This finding indicated that bromelain could have an inhibitory effect on different SARS-CoV-2 variants.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2021 ;12:717757. Epub 2021 Aug 20. PMID: 34489706

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Bromelain

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

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View the Evidence: 111 Abstracts with Bromelain Research

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A supplement with Ribes Nigrum, Boswellia Serrata, bromelain and vitamin D to stop local inflammation in chronic sinusitis.Apr 17, 2023

Benefits of a food supplement containing Boswellia serrata and bromelain for improving the quality of life in patients with osteoarthritis.Oct 31, 2019

Bromelain has anti-platelet properties.Feb 01, 2006

Bromelain has antimetastic protential as demonstrated in lung cancer cells - Article 1. Jan 01, 1988

Bromelain has no difference in reducing symptoms of mild-to-moderate knee OA after 4 weeks when compared with diclofenac.Sep 30, 2016

Bromelain is effective in treating postoperative edema after third molar surgery.Sep 01, 2010

Bromelain may benefit children diagnosed with acute sinusitis. Mar 01, 2005

Bromelain may benefit patients with postoperative constipation. Sep 01, 2007

Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults.Dec 01, 2002

OPERA was able to improve CIPN symptoms in a prospective series of patients treated with neurotoxic chemotherapy.Feb 28, 2017

Sodium alginate, sodium bicarbonate, bromelain and essential oils have therapeutic value in the treatment of functional dyspepsia.Jun 01, 2009

The combination of serenoa repens, selenium, lycopene and bromelain are beneficial in patients with chronic bacterial prostatitis.Oct 04, 2016

These results showed the effectiveness of bromelain on episiotomy pain and wound healing.Feb 29, 2016

This study thus clearly supports the clinical relevance of treatment of postoperative conditions with bromelain.Sep 05, 2016

Treatment of COVID-19 patients with quercetin: a prospective, single center, randomized, controlled trial.Dec 31, 2020

Anti-cancer activity of bromelain nanoparticles by oral administration.Nov 30, 2014

Bromelain degrades Aβ1-42 monomers and soluble aggregates.Jan 22, 2018

Bromelain extract exerts antiarthritic effects via chondroprotection.Oct 22, 2021

Bromelain mitigates liver fibrosis via targeting hepatic stellate cells.May 31, 2023

Addition of bromelain and acetylcysteine to gemcitabine potentiates tumor inhibition in vivo in human colon cancer cell line LS174T.Dec 31, 2020

Ameliorative effects of bromelain on aluminum-induced Alzheimer's disease.Jan 31, 2023

Antinociceptive and neuroprotective effects of bromelain in chronic constriction injury-induced neuropathic pain.Dec 31, 2019

Bromelain Ameliorates Atherosclerosis.Dec 28, 2022

Bromelain ameliorates D-galactosamine-induced acute liver injury.Nov 24, 2022

Bromelain ameliorates hepatic microcirculation after warm ischemia indicating it may have liver protective effects after injury. May 01, 2007

Bromelain and acetylcysteine alone and in combination with gemcitabine inhibit subcutaneous deposits of pancreatic cancer after intraperitoneal injection.Dec 31, 2020

Bromelain and fresh pineapple juice have a therapeutic effect in acute crush archilles tendon injury.Apr 01, 2011

Bromelain attenuates inflammation in an experimental mouse model of asthma. Mar 01, 2008

Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease.Sep 01, 2005

Bromelain has a healing effect in acute crush Archilles tendon injury. Jan 01, 2009

Bromelain has a therapeutic effect in established allergic airway disease.Aug 31, 2012

Bromelain has cardioprotective properties against an experimental model of heart injury. Mar 01, 2008

Bromelain has immunomodulatory properties. Dec 20, 2006

Bromelain has the potential to reduce the side effects of BPA on the male reproductive system.Nov 30, 2022

Bromelain increases milk yield, milk composition and has no adverse effects on mammary health in dairy goats.Apr 01, 2009

Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy.Dec 31, 2018

Bromelain loaded nano lipid carriers opens new avenue for development of novel effective therapeutic modality for rheumatoid arthritis management.Jan 31, 2021

Bromelain may be an option in periodontal therapy by regulating cytokine levels, improving the healing process, and reducing bone resorption.Jul 31, 2023

Bromelain mitigated electrolyte imbalance in chronic constricted injury of the sciatic nerve.Oct 25, 2019

Bromelain modulates liver injury, hematological, molecular, and biochemical perturbations induced by aluminum.Dec 31, 2021

Bromelain plus peroxidase reduces non-Hodgkin lymphoma progressionOct 07, 2019

Bromelain protects against cisplatin-induced ocular toxicity through mitigating oxidative stress and inflammation.Dec 12, 2021

Bromelain reduced pro-inflammatory mediators as a common pathway that mediate antinociceptive and anti-anxiety effects in a sciatic nerve ligation model.Jan 10, 2021

Bromelain represents a novel approach to the treatment of metal toxicity.May 31, 2015

Bromelain treatment decreases neutrophil migration to sites of inflammation.Jul 01, 2008

Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in mice with colitis.Dec 01, 2010

Effect of bromelain on mast cell numbers and degranulation in diabetic rat wound healing.Jul 31, 2022

Enhancement of the anti-inflammatory effect of bromelain by its immobilization on probiotic spore of Bacillus cereus.Nov 05, 2020

Nephroprotective role of bromelain against oxidative injury induced by aluminium.Oct 31, 2020

Pharmacological evaluation of bromelain in mouse model of Alzheimer's disease.Dec 31, 2021

Pineapple bromelain has anti-tumor properties superior to the chemo-agent 5-fluorouracil.Oct 01, 2007

Protective effect of bromelain on corrosive burns.Dec 09, 2020

Protective effects of bromelain against cadmium-induced pulmonary intoxication.Jan 10, 2021

Protein stem bromelain together with all-trans retinoic-acid (atRA), may be a potent modulator of obesity by repressing the PPARγ-regulated adipogenesis pathwayDec 31, 2011

Study of the radiosensitizing and radioprotective efficacy of bromelain.Dec 31, 2019

The ameliorative effect of bromelain on STZ-induced type 1 diabetes.Nov 14, 2021

The present study provides new insights into the potential therapeutic value of bromelain for the prevention and treatment of thrombosis-related diseases.May 31, 2022

Therapeutic effect of bromelain and papain on intestinal injury induced by indomethacin.Dec 31, 2022

These results supply novel insights into potential inflammatory bowel disease treatment by purified fruit bromelain.Dec 31, 2016

Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease.Aug 01, 2005

Use of bromelain in cutaneous wound healing in streptozocin-induced diabetes.Sep 01, 2020

The Combination ofBromelain and acetylcysteine (BromAc) synergistically inactivates SARS-CoV-2.Jan 05, 2021

"Bromelain: biochemistry, pharmacology and medical use."Jul 31, 2001

Anti-cancer effect of bromelain and its combination with cisplatin on HN5 cell line.Aug 31, 2022

Anti-inflammatory and mineralization effects of bromelain on lipopolysaccharide-induced inflammation.Jun 07, 2021

Anti-inflammatory effect of pineapple rhizome bromelain.May 06, 2021

Anti-inflammatory properties of a proprietary bromelain extract.Dec 31, 2020

Bromelain a potential bioactive compound: A comprehensive overview.Apr 05, 2021

Bromelain and NAC inhibit the growth, proliferation and survival of human gastrointestinal cancer cells.Nov 11, 2014

Bromelain and Olea europaea (L.) leaf extract mediated alleviation of benzo(a)pyrene induced lung cancer.Apr 22, 2021

Bromelain and papain exhibit anti-flu virion properties.May 01, 2008

Bromelain

View the Evidence:
111 Abstracts with Bromelain Research