Bromelain

Views 29698
Jump to
Abstracts Focused Research Topics
Download the GMI DOC on this Topic

Focus Your Research

Click any topic below to filter + focus research
68 Diseases Researched for Bromelain
NameACCKFocus
Osteoarthritis: Knee220Locked
Inflammation819Locked
Wound Healing414Locked
Lung Cancer212Locked
Thrombosis211Locked
Breast Cancer610Locked
Cancers: All510Locked
Chemotherapy-Induced Toxicity: Peripheral Neuropathy110Locked
Constipation: Post-Operative110Locked
Dyspepsia110Locked
Edema110Locked
Oral Surgical Procedures110Locked
Osteoarthritis110Locked
Pain110Locked
Perineal trauma 110Locked
Postoperative Edema110Locked
Postoperative Recovery110Locked
Prostatitis: Bacterial110Locked
Sinusitis110Locked
Tooth Extraction: Wisdom110Locked
Colorectal Cancer38Locked
Alzheimer's Disease15Locked
Cervical Cancer15Locked
Inflammatory Bowel Diseases35Locked
Allergic Airway Diseases24Locked
Asthma24Locked
Colitis24Locked
Coronavirus Infection44Locked
Neuropathic Pain24Locked
Tendon Injury24Locked
Skin Cancer33Locked
Aluminum Toxicity 12Locked
Breastfeeding: Complications12Locked
Burns12Locked
Cancer Metastasis12Locked
Colon Cancer12Locked
Diabetic Complications12Locked
Gastric Cancer22Locked
Gastrointestinal Inflammation12Locked
Kidney Damage: Chemically-Induced12Locked
Lactation Disorders12Locked
Lead Poisoning12Locked
Lipopolysaccharide-Induced Toxicity22Locked
Liver Damage12Locked
Myocardial Infarction12Locked
Myocardial Ischemia12Locked
Non-Hodgkin Lymphoma12Locked
Obesity12Locked
Oxidative Stress12Locked
Rheumatoid Arthritis12Locked
Sciatic Nerve Crush Injury12Locked
Breast Cancer: Triple Negative 11Locked
Cholangiocarcinoma11Locked
Cholera11Locked
Escherichia coli Infections11Locked
Glioma11Locked
Gram-Positive Bacterial Infections11Locked
Immune Disorders11Locked
Influenza11Locked
Intestinal Permeability 11Locked
Leaky Gut Syndrome11Locked
Liver Cancer11Locked
Melanoma11Locked
Oral Cancer11Locked
Pancreatic Cancer11Locked
Periodontal Diseases11Locked
Prostate Cancer11Locked
Thrombophlebitis11Locked
54 Pharmacological Actions Researched for Bromelain
NameACCKFocus
Anti-Inflammatory Agents2369Locked
Analgesics330Locked
Anti-Bacterial Agents422Locked
Apoptotic1220Locked
Anti-metastatic414Locked
Immunomodulatory312Locked
Malondialdehyde Down-regulation212Locked
Anti-Platelet211Locked
Antiproliferative 810Locked
Chemoprotective Agents110Locked
Osteoprotective 110Locked
Prostaglandin PGE2 downregulation110Locked
Neuroprotective Agents39Locked
Antineoplastic Agents48Locked
Antinoceceptive 36Locked
Interleukin-10 downregulation36Locked
Antioxidants35Locked
NF-kappaB Inhibitor55Locked
Antiviral Agents44Locked
Cyclooxygenase 2 Inhibitors44Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor34Locked
Autophagy Up-regulation23Locked
Interleukin-1 beta downregulation23Locked
Interleukin-4 downregulation23Locked
Interleukin-6 Downregulation23Locked
Radiosensitizer23Locked
Anti-Adipogenic12Locked
Anti-Allergic Agents12Locked
Anti-Anxiety Agents12Locked
Anti-Asthmatic Agents12Locked
Anticarcinogenic Agents22Locked
Bcl-2 protein down-regulation22Locked
Cardioprotective12Locked
Chemosensitizer22Locked
Cytoprotective12Locked
Cytotoxic22Locked
Hepatoprotective12Locked
Immunostimulatory22Locked
Interferon Gamma Reducer12Locked
Interleukin-12 downregulation12Locked
Interleukin-17 downregulation12Locked
Postaglandin PGE2 downregulation 12Locked
Radioprotective12Locked
Renoprotective12Locked
Tumor Suppressor Protein p53 Upregulation22Locked
Anti-thrombotic11Locked
Anticoagulants11Locked
Antifibrinolytic Agents11Locked
Antimicrobial11Locked
Cell cycle arrest11Locked
Chemopreventive11Locked
Chemotherapeutic11Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor11Locked
Thrombolytic11Locked
Related Topics

Bromelain is a Sub of the following Topics

FREE Member Preview Enabled
  • You are viewing this page with some membership features unlocked
  • To unlock all the great features and content on GMI, please support us by becoming a Power User member

View the Evidence:
111 Abstracts with Bromelain Research

[+]

A supplement with Ribes Nigrum, Boswellia Serrata, bromelain and vitamin D to stop local inflammation in chronic sinusitis.Apr 17, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Med. 2023 Apr 18 ;12(8). Epub 2023 Apr 18. PMID: 37109265
Article Published Date : Apr 17, 2023
Study Type : Human Study
Additional Links
Substances : Black Currant, Bromelain, Frankincense, Vitamin D
Diseases : Inflammation, Sinusitis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Benefits of a food supplement containing Boswellia serrata and bromelain for improving the quality of life in patients with osteoarthritis.Oct 31, 2019

Pubmed Data : J Altern Complement Med. 2019 Nov 1. Epub 2019 Nov 1. PMID: 31674795
Article Published Date : Oct 31, 2019
Study Type : Human Study
Additional Links
Substances : Bromelain, Frankincense
Diseases : Osteoarthritis
Pharmacological Actions : Osteoprotective
[+]

Bromelain has anti-platelet properties.Feb 01, 2006

Pubmed Data : Platelets. 2006 Feb;17(1):37-41. PMID: 16308185
Article Published Date : Feb 01, 2006
Study Type : Human Study
Additional Links
Substances : Bromelain
Diseases : Thrombosis
Pharmacological Actions : Anti-Platelet
[+]

Bromelain has antimetastic protential as demonstrated in lung cancer cells - Article 1. Jan 01, 1988

Pubmed Data : J Cancer Res Clin Oncol. 1988;114(5):507-8. PMID: 3182910
Article Published Date : Jan 01, 1988
Study Type : Human Study
Additional Links
Substances : Bromelain, Pineapple
Diseases : Lung Cancer
Pharmacological Actions : Anti-metastatic
[+]

Bromelain has no difference in reducing symptoms of mild-to-moderate knee OA after 4 weeks when compared with diclofenac.Sep 30, 2016

Pubmed Data : Clin Rheumatol. 2016 Oct ;35(10):2531-40. Epub 2016 Jul 28. PMID: 27470088
Article Published Date : Sep 30, 2016
Study Type : Human Study
Additional Links
Substances : Bromelain
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Anti-Inflammatory Agents, Malondialdehyde Down-regulation, Prostaglandin PGE2 downregulation
Problem Substances : Diclofenac
[+]

Bromelain is effective in treating postoperative edema after third molar surgery.Sep 01, 2010

Pubmed Data : Eur Rev Med Pharmacol Sci. 2010 Sep;14(9):771-4. PMID: 21061836
Article Published Date : Sep 01, 2010
Study Type : Human Study
Additional Links
Substances : Bromelain
Diseases : Edema, Oral Surgical Procedures, Postoperative Edema, Postoperative Recovery
Pharmacological Actions : Analgesics, Anti-Bacterial Agents, Anti-Inflammatory Agents
Additional Keywords : Dental
[+]

Bromelain may benefit children diagnosed with acute sinusitis. Mar 01, 2005

Pubmed Data : In Vivo. 2005 Mar-Apr;19(2):417-21. PMID: 15796206
Article Published Date : Mar 01, 2005
Study Type : Human Study
Additional Links
Substances : Bromelain
Diseases : Sinusitis
[+]

Bromelain may benefit patients with postoperative constipation. Sep 01, 2007

Pubmed Data : Pharmacol Res. 2007 Sep;56(3):254-60. Epub 2007 Jul 14. PMID: 16137711
Article Published Date : Sep 01, 2007
Study Type : Human Study
Additional Links
Substances : Bromelain
Diseases : Constipation: Post-Operative
[+]

Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults.Dec 01, 2002

Pubmed Data : Phytomedicine. 2002 Dec;9(8):681-6. PMID: 12587686
Article Published Date : Dec 01, 2002
Study Type : Human Study
Additional Links
Substances : Bromelain
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Analgesics
[+]

OPERA was able to improve CIPN symptoms in a prospective series of patients treated with neurotoxic chemotherapy.Feb 28, 2017

Pubmed Data : Med Oncol. 2017 Mar ;34(3):46. Epub 2017 Feb 15. PMID: 28205185
Article Published Date : Feb 28, 2017
Study Type : Human Study
Additional Links
Substances : Alpha-Lipoic Acid, Bromelain
Diseases : Chemotherapy-Induced Toxicity: Peripheral Neuropathy
Pharmacological Actions : Chemoprotective Agents
[+]

Sodium alginate, sodium bicarbonate, bromelain and essential oils have therapeutic value in the treatment of functional dyspepsia.Jun 01, 2009

Pubmed Data : Clin Exp Allergy. 2009 Jun;39(6):875-82. PMID: 19829282
Article Published Date : Jun 01, 2009
Study Type : Human Study
Additional Links
Substances : Bromelain, Essential Oils: Unspecified, Sodium Alginate, Sodium Bicarbonate
Diseases : Dyspepsia
[+]

The combination of serenoa repens, selenium, lycopene and bromelain are beneficial in patients with chronic bacterial prostatitis.Oct 04, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Ital Urol Androl. 2016 Oct 5 ;88(3):177-182. Epub 2016 Oct 5. PMID: 27711089
Article Published Date : Oct 04, 2016
Study Type : Human Study
Additional Links
Substances : Bromelain, Lycopene, Saw Palmetto, Selenium
Diseases : Prostatitis: Bacterial
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

These results showed the effectiveness of bromelain on episiotomy pain and wound healing.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran Red Crescent Med J. 2016 Mar ;18(3):e21019. Epub 2016 Mar 1. PMID: 27247780
Article Published Date : Feb 29, 2016
Study Type : Human Study
Additional Links
Substances : Bromelain, Pineapple
Diseases : Pain, Perineal trauma , Wound Healing
Pharmacological Actions : Analgesics
[+]

This study thus clearly supports the clinical relevance of treatment of postoperative conditions with bromelain.Sep 05, 2016

Pubmed Data : Phytother Res. 2016 Sep 6. Epub 2016 Sep 6. PMID: 27601419
Article Published Date : Sep 05, 2016
Study Type : Human Study
Additional Links
Substances : Bromelain
Diseases : Tooth Extraction: Wisdom
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Treatment of COVID-19 patients with quercetin: a prospective, single center, randomized, controlled trial.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Turk J Biol. 2021 ;45(4):518-529. Epub 2021 Aug 30. PMID: 34803451
Article Published Date : Dec 31, 2020
Study Type : Human Study
Additional Links
Substances : Bromelain, Quercetin, Vitamin C
Diseases : Coronavirus Infection
[+]

Anti-cancer activity of bromelain nanoparticles by oral administration.Nov 30, 2014

Pubmed Data : J Biomed Nanotechnol. 2014 Dec ;10(12):3558-75. PMID: 26000370
Article Published Date : Nov 30, 2014
Study Type : Human In Vitro
Additional Links
Substances : Bromelain
Diseases : Breast Cancer, Cancers: All, Cervical Cancer, Colorectal Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic
[+]

Bromelain degrades Aβ1-42 monomers and soluble aggregates.Jan 22, 2018

Pubmed Data : Curr Alzheimer Res. 2018 Jan 23. Epub 2018 Jan 23. PMID: 29359669
Article Published Date : Jan 22, 2018
Study Type : Human In Vitro
Additional Links
Substances : Bromelain
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Bromelain extract exerts antiarthritic effects via chondroprotection.Oct 22, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Plants (Basel). 2021 Oct 23 ;10(11). Epub 2021 Oct 23. PMID: 34834636
Article Published Date : Oct 22, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Inflammation, Osteoarthritis, Rheumatoid Arthritis
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Chondroprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Bromelain mitigates liver fibrosis via targeting hepatic stellate cells.May 31, 2023

Pubmed Data : Tissue Cell. 2023 Jun ;82:102118. Epub 2023 May 27. PMID: 37269556
Article Published Date : May 31, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective
[+]

Addition of bromelain and acetylcysteine to gemcitabine potentiates tumor inhibition in vivo in human colon cancer cell line LS174T.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Cancer Res. 2021 ;11(5):2252-2263. Epub 2021 May 15. PMID: 34094682
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bromelain, Cysteine (see N-Acetylcysteine)
Diseases : Colon Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Ameliorative effects of bromelain on aluminum-induced Alzheimer's disease.Jan 31, 2023

Pubmed Data : Int J Biol Macromol. 2023 Feb 1 ;227:1119-1131. Epub 2022 Dec 1. PMID: 36462588
Article Published Date : Jan 31, 2023
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Aluminum
[+]

Antinociceptive and neuroprotective effects of bromelain in chronic constriction injury-induced neuropathic pain.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Pain. 2020 Jan 1 ;33(1):13-22. PMID: 31888313
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Neuropathic Pain
Pharmacological Actions : Antinoceceptive , Neuroprotective Agents
[+]

Bromelain Ameliorates Atherosclerosis.Dec 28, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2022 Dec 29 ;12(1). Epub 2022 Dec 29. PMID: 36670934
Article Published Date : Dec 28, 2022
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Atherosclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hypolipidemic
[+]

Bromelain ameliorates D-galactosamine-induced acute liver injury.Nov 24, 2022

Pubmed Data : J Pharm Pharmacol. 2022 Nov 25 ;74(12):1765-1775. PMID: 36227279
Article Published Date : Nov 24, 2022
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Bromelain ameliorates hepatic microcirculation after warm ischemia indicating it may have liver protective effects after injury. May 01, 2007

Pubmed Data : J Surg Res. 2007 May 1;139(1):88-96. Epub 2007 Feb 8. PMID: 17292418
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Liver Damage
Pharmacological Actions : Hepatoprotective
[+]

Bromelain and acetylcysteine alone and in combination with gemcitabine inhibit subcutaneous deposits of pancreatic cancer after intraperitoneal injection.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2021 ;13(12):13524-13539. Epub 2021 Dec 15. PMID: 35035694
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bromelain, NAC (N-acetyl-L-cysteine)
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Bromelain and fresh pineapple juice have a therapeutic effect in acute crush archilles tendon injury.Apr 01, 2011

Pubmed Data : J Med Food. 2011 Apr;14(4):348-52. Epub 2011 Jan 23. PMID: 21254908
Article Published Date : Apr 01, 2011
Study Type : Animal Study
Additional Links
Substances : Bromelain, Pineapple
Diseases : Tendon Injury
[+]

Bromelain attenuates inflammation in an experimental mouse model of asthma. Mar 01, 2008

Pubmed Data : Evid Based Complement Alternat Med. 2008 Mar;5(1):61-9. PMID: 18317550
Article Published Date : Mar 01, 2008
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Asthma
Pharmacological Actions : Anti-Asthmatic Agents
[+]

Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease.Sep 01, 2005

Pubmed Data : Cell Immunol. 2005 Sep;237(1):68-75. Epub 2005 Dec 6. PMID: 16337164
Article Published Date : Sep 01, 2005
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Allergic Airway Diseases
Pharmacological Actions : Anti-Allergic Agents, Anti-Inflammatory Agents
[+]

Bromelain has a healing effect in acute crush Archilles tendon injury. Jan 01, 2009

Pubmed Data : Ann Nutr Metab. 2009;54(4):283-90. Epub 2009 Jul 27. PMID: 20623610
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Tendon Injury
[+]

Bromelain has a therapeutic effect in established allergic airway disease.Aug 31, 2012

Pubmed Data : Altern Ther Health Med. 2012 Sep-Oct;18(5):9-17. PMID: 22894886
Article Published Date : Aug 31, 2012
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Allergic Airway Diseases, Asthma
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-12 downregulation, Interleukin-17 downregulation, Interleukin-4 downregulation
[+]

Bromelain has cardioprotective properties against an experimental model of heart injury. Mar 01, 2008

Pubmed Data : Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1365-70. Epub 2008 Jan 11. PMID: 18192224
Article Published Date : Mar 01, 2008
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Myocardial Infarction, Myocardial Ischemia
Pharmacological Actions : Apoptotic, Cardioprotective
[+]

Bromelain has immunomodulatory properties. Dec 20, 2006

Pubmed Data : Int Immunopharmacol. 2006 Dec 20;6(13-14):2038-46. Epub 2006 Sep 5. PMID: 17161360
Article Published Date : Dec 20, 2006
Study Type : Animal Study
Additional Links
Substances : Bromelain
Pharmacological Actions : Interleukin-10 downregulation
[+]

Bromelain has the potential to reduce the side effects of BPA on the male reproductive system.Nov 30, 2022

Pubmed Data : Andrologia. 2022 Dec ;54(11):e14584. Epub 2022 Sep 6. PMID: 36068179
Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Bisphenol Toxicity, Oxidative Stress, Sperm Quality: Low
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation
Additional Keywords : Estrogen Receptor Beta
Problem Substances : Bisphenol A
[+]

Bromelain increases milk yield, milk composition and has no adverse effects on mammary health in dairy goats.Apr 01, 2009

Pubmed Data : Trop Anim Health Prod. 2009 Apr;41(4):493-8. Epub 2008 Jul 27. PMID: 18661260
Article Published Date : Apr 01, 2009
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Breastfeeding: Complications, Lactation Disorders
[+]

Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2019 ;14(1):e0210274. Epub 2019 Jan 18. PMID: 30657763
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation
[+]

Bromelain loaded nano lipid carriers opens new avenue for development of novel effective therapeutic modality for rheumatoid arthritis management.Jan 31, 2021

Pubmed Data : Int J Pharm. 2021 Feb 1 ;594:120176. Epub 2020 Dec 14. PMID: 33326825
Article Published Date : Jan 31, 2021
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Bromelain may be an option in periodontal therapy by regulating cytokine levels, improving the healing process, and reducing bone resorption.Jul 31, 2023

Pubmed Data : Int Immunopharmacol. 2023 Aug ;121:110446. Epub 2023 Jun 7. PMID: 37290321
Article Published Date : Jul 31, 2023
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Bromelain mitigated electrolyte imbalance in chronic constricted injury of the sciatic nerve.Oct 25, 2019

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 Oct 26. Epub 2019 Oct 26. PMID: 31655851
Article Published Date : Oct 25, 2019
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Sciatic Nerve Crush Injury
Pharmacological Actions : Antinoceceptive
[+]

Bromelain modulates liver injury, hematological, molecular, and biochemical perturbations induced by aluminum.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2022 ;2022:5342559. Epub 2022 Nov 21. PMID: 36452063
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Aluminum Toxicity , Chemically-Induced Liver Damage, Inflammation, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Aluminum
[+]

Bromelain plus peroxidase reduces non-Hodgkin lymphoma progressionOct 07, 2019

Pubmed Data : Nutr Cancer. 2019 Oct 8:1-11. Epub 2019 Oct 8. PMID: 31591915
Article Published Date : Oct 07, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bromelain, Pineapple
Diseases : Non-Hodgkin Lymphoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Bromelain protects against cisplatin-induced ocular toxicity through mitigating oxidative stress and inflammation.Dec 12, 2021

Pubmed Data : Drug Chem Toxicol. 2021 Dec 13:1-8. Epub 2021 Dec 13. PMID: 34894956
Article Published Date : Dec 12, 2021
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents
[+]

Bromelain reduced pro-inflammatory mediators as a common pathway that mediate antinociceptive and anti-anxiety effects in a sciatic nerve ligation model.Jan 10, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2021 Jan 11 ;11(1):289. Epub 2021 Jan 11. PMID: 33432004
Article Published Date : Jan 10, 2021
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Neuropathic Pain
Pharmacological Actions : Anti-Anxiety Agents, Antinoceceptive , Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Bromelain represents a novel approach to the treatment of metal toxicity.May 31, 2015

Pubmed Data : Acta Biol Hung. 2015 Jun ;66(2):149-60. PMID: 26081271
Article Published Date : May 31, 2015
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Lead Poisoning
Pharmacological Actions : Cytoprotective, Malondialdehyde Down-regulation
Problem Substances : Lead
[+]

Bromelain treatment decreases neutrophil migration to sites of inflammation.Jul 01, 2008

Pubmed Data : Clin Immunol. 2008 Jul;128(1):66-74. Epub 2008 May 14. PMID: 18482869
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in mice with colitis.Dec 01, 2010

Pubmed Data : Inflamm Bowel Dis. 2010 Dec;16(12):2012-21. PMID: 20848493
Article Published Date : Dec 01, 2010
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Colitis, Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation
[+]

Effect of bromelain on mast cell numbers and degranulation in diabetic rat wound healing.Jul 31, 2022

Pubmed Data : J Wound Care. 2022 Aug 1 ;31(Sup8):S4-S11. PMID: 36004940
Article Published Date : Jul 31, 2022
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Diabetic Complications, Wound Healing
[+]

Enhancement of the anti-inflammatory effect of bromelain by its immobilization on probiotic spore of Bacillus cereus.Nov 05, 2020

Pubmed Data : Probiotics Antimicrob Proteins. 2020 Nov 6. Epub 2020 Nov 6. PMID: 33156496
Article Published Date : Nov 05, 2020
Study Type : Animal Study
Additional Links
Substances : Bromelain, Probiotics
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Nephroprotective role of bromelain against oxidative injury induced by aluminium.Oct 31, 2020

Pubmed Data : Environ Toxicol Pharmacol. 2020 Nov ;80:103509. Epub 2020 Oct 1. PMID: 33010469
Article Published Date : Oct 31, 2020
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Aluminum Toxicity , Kidney Damage: Chemically-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Renoprotective
Problem Substances : Aluminum
[+]

Pharmacological evaluation of bromelain in mouse model of Alzheimer's disease.Dec 31, 2021

Pubmed Data : Neurotoxicology. 2022 05 ;90:19-34. Epub 2022 Feb 24. PMID: 35219781
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Pineapple bromelain has anti-tumor properties superior to the chemo-agent 5-fluorouracil.Oct 01, 2007

Pubmed Data : Planta Med. 2007 Oct;73(13):1377-83. Epub 2007 Sep 24. PMID: 17893836
Article Published Date : Oct 01, 2007
Study Type : Animal Study
Additional Links
Substances : Bromelain, Pineapple
Diseases : Cancer Metastasis, Lung Cancer
Pharmacological Actions : Anti-metastatic
Additional Keywords : Drug: 5-flourouracil, Food as Medicine, Hall of Fame, Superiority of Natural Substances versus Drugs
[+]

Protective effect of bromelain on corrosive burns.Dec 09, 2020

Pubmed Data : Burns. 2020 Dec 10. Epub 2020 Dec 10. PMID: 33934907
Article Published Date : Dec 09, 2020
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Burns
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Protective effects of bromelain against cadmium-induced pulmonary intoxication.Jan 10, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Razi Inst. 2021 11 ;76(5):1427-1436. Epub 2021 Nov 30. PMID: 35355740
Article Published Date : Jan 10, 2021
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Cadmium Poisoning
Pharmacological Actions : Anti-Inflammatory Agents
Problem Substances : Cadmium
[+]

Protein stem bromelain together with all-trans retinoic-acid (atRA), may be a potent modulator of obesity by repressing the PPARγ-regulated adipogenesis pathwayDec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(1):e30831. Epub 2012 Jan 24. PMID: 22292054
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Obesity
Pharmacological Actions : Anti-Adipogenic, Apoptotic
Additional Keywords : Anti-Obesity Agents
[+]

Study of the radiosensitizing and radioprotective efficacy of bromelain.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Cancer Ther. 2020 Jan-Dec;19:1534735420950468. PMID: 32783540
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Cancers: All
Pharmacological Actions : Radioprotective, Radiosensitizer
[+]

The ameliorative effect of bromelain on STZ-induced type 1 diabetes.Nov 14, 2021

Pubmed Data : Life Sci. 2021 Nov 15 ;285:119982. Epub 2021 Sep 27. PMID: 34592232
Article Published Date : Nov 14, 2021
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Malondialdehyde Down-regulation
[+]

The present study provides new insights into the potential therapeutic value of bromelain for the prevention and treatment of thrombosis-related diseases.May 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2022 Jun 1 ;14(11). Epub 2022 Jun 1. PMID: 35684129
Article Published Date : May 31, 2022
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Nonalcoholic fatty liver disease (NAFLD), Thrombosis
Pharmacological Actions : Anticoagulants, Hepatoprotective
[+]

Therapeutic effect of bromelain and papain on intestinal injury induced by indomethacin.Dec 31, 2022

Pubmed Data : Int J Health Sci (Qassim). 2023 ;17(5):23-30. PMID: 37692988
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Bromelain, Papain
Diseases : Drug-Induced Toxicity: Indomethacin
Pharmacological Actions : Gastroprotective
Problem Substances : Indomethacin
[+]

These results supply novel insights into potential inflammatory bowel disease treatment by purified fruit bromelain.Dec 31, 2016

Pubmed Data : Front Immunol. 2017 ;8:1468. Epub 2017 Nov 10. PMID: 29176974
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Gastrointestinal Inflammation, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease.Aug 01, 2005

Pubmed Data : Clin Immunol. 2005 Aug;116(2):135-42. PMID: 15936249
Article Published Date : Aug 01, 2005
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Colitis, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation
[+]

Use of bromelain in cutaneous wound healing in streptozocin-induced diabetes.Sep 01, 2020

Pubmed Data : J Wound Care. 2020 Sep 2 ;29(9):488-495. PMID: 32924815
Article Published Date : Sep 01, 2020
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Diabetic Complications, Wound Healing
Pharmacological Actions : Anti-Inflammatory Agents
[+]

The Combination ofBromelain and acetylcysteine (BromAc) synergistically inactivates SARS-CoV-2.Jan 05, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Viruses. 2021 03 6 ;13(3). Epub 2021 Mar 6. PMID: 33800932
Article Published Date : Jan 05, 2021
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, NAC (N-acetyl-L-cysteine)
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

"Bromelain: biochemistry, pharmacology and medical use."Jul 31, 2001

Pubmed Data : Cell Mol Life Sci. 2001 Aug ;58(9):1234-45. PMID: 11577981
Article Published Date : Jul 31, 2001
Study Type : Review
Additional Links
Substances : Bromelain
Diseases : Thrombophlebitis
Additional Keywords : Phytotherapy
[+]

Anti-cancer effect of bromelain and its combination with cisplatin on HN5 cell line.Aug 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Dent (Shiraz). 2022 Sep ;23(3):257-265. PMID: 36506883
Article Published Date : Aug 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents
[+]

Anti-inflammatory and mineralization effects of bromelain on lipopolysaccharide-induced inflammation.Jun 07, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicina (Kaunas). 2021 Jun 8 ;57(6). Epub 2021 Jun 8. PMID: 34201357
Article Published Date : Jun 07, 2021
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Anti-inflammatory effect of pineapple rhizome bromelain.May 06, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Curr Issues Mol Biol. 2021 May 7 ;43(1):93-106. Epub 2021 May 7. PMID: 34067064
Article Published Date : May 06, 2021
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Anti-inflammatory properties of a proprietary bromelain extract.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211034686. PMID: 34387509
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Inflammation, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Bromelain a potential bioactive compound: A comprehensive overview.Apr 05, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Life (Basel). 2021 Apr 6 ;11(4). Epub 2021 Apr 6. PMID: 33917319
Article Published Date : Apr 05, 2021
Study Type : Review
Additional Links
Substances : Bromelain
Diseases : Arthritis, Digestive System Diseases, Respiratory Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Antimicrobial, Immunomodulatory
[+]

Bromelain and NAC inhibit the growth, proliferation and survival of human gastrointestinal cancer cells.Nov 11, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2014 Nov 12 ;33:92. Epub 2014 Nov 12. PMID: 25425315
Article Published Date : Nov 11, 2014
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, NAC (N-acetyl-L-cysteine)
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Natural Substance Synergy
[+]

Bromelain and Olea europaea (L.) leaf extract mediated alleviation of benzo(a)pyrene induced lung cancer.Apr 22, 2021

Pubmed Data : Environ Sci Pollut Res Int. 2021 Apr 23. Epub 2021 Apr 23. PMID: 33893581
Article Published Date : Apr 22, 2021
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, Olive leaf extract
Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Natural Substance Synergy
Problem Substances : Benzo(a)pyrene
[+]

Bromelain and papain exhibit anti-flu virion properties.May 01, 2008

Pubmed Data : Bioorg Khim. 2008 May-Jun;34(3):409-15. PMID: 18672693
Article Published Date : May 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, Papain
Diseases : Influenza
Pharmacological Actions : Antiviral Agents
[+]

Bromelain and papain have cytotoxic effects on human cholangiocarcinoma cell lines.Apr 30, 2016

Pubmed Data : Int J Oncol. 2016 May ;48(5):2025-34. Epub 2016 Mar 1. PMID: 26935541
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, Papain
Diseases : Cholangiocarcinoma
Pharmacological Actions : Anti-Inflammatory Agents, Cytotoxic, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
[+]

Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anim Cells Syst (Seoul). 2018 ;22(5):334-340. Epub 2018 Aug 30. PMID: 30460115
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Cytotoxic
[+]

Bromelain enhances intestinal absorption and/or permeability. Jan 24, 2005

Pubmed Data : Arch Intern Med. 2005 Jan 24;165(2):200-6. PMID: 16950580
Article Published Date : Jan 24, 2005
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Intestinal Permeability , Leaky Gut Syndrome
[+]

Bromelain exerts an antibacterial effect against potent periodontal pathogens.Aug 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Int Oral Health. 2014 Sep ;6(5):96-8. PMID: 25395802
Article Published Date : Aug 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, Pineapple
Diseases : Periodontal Diseases
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Plant Extracts
[+]

Bromelain exerts anti-inflammatory activity by modulating activated CD4(+) cells. Mar 01, 2009

Pubmed Data : Int Immunopharmacol. 2009 Mar;9(3):340-6. Epub 2009 Jan 20. PMID: 19162239
Article Published Date : Mar 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Bromelain exhibits anti-skin cancer and anti-melanoma activity. Mar 22, 2011

Pubmed Data : Mol Carcinog. 2011 Mar 22. Epub 2011 Mar 22. PMID: 21432909
Article Published Date : Mar 22, 2011
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Melanoma, Skin Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, NF-kappaB Inhibitor
[+]

Bromelain has anti-tumor initiating activity against skin cancer cells.Sep 18, 2009

Pubmed Data : Cancer Lett. 2009 Sep 18;282(2):167-76. Epub 2009 Mar 31. PMID: 19339108
Article Published Date : Sep 18, 2009
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Bromelain has inhibitory effects on colony formation in cancer cells.Sep 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Signals Sens. 2019 Oct-Dec;9(4):267-273. Epub 2019 Oct 24. PMID: 31737556
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Breast Cancer, Gastric Cancer, Prostate Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

Bromelain in combination with cisplatin synergistically enhanced the induction of apoptosis in MDA-MB-231 cells.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Chin Med. 2016 ;11:46. Epub 2016 Nov 15. PMID: 27891174
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Bromelain induces apoptosis-related cell death in breast cancer cells with increasing concentrations in vitro.Apr 01, 2012

Pubmed Data : J Med Food. 2012 Apr ;15(4):344-9. Epub 2011 Dec 22. PMID: 22191568
Article Published Date : Apr 01, 2012
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Antitumorigenic, Apoptosis, Breast Cancer, Bromelain
Anti Therapeutic Actions : Nocebo Effect
[+]

Bromelain inhibits invasive properties of glioma cells. Nov 01, 2001

Pubmed Data : Neoplasia. 2001 Nov-Dec;3(6):469-79. PMID: 11774029
Article Published Date : Nov 01, 2001
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Glioma
[+]

Bromelain inhibits lipopolysaccharide-induced inflammation. Jan 01, 2003

Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2003;23(2):151-3. PMID: 18569070
Article Published Date : Jan 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Bromelain inhibits SARS-CoV-2 infection in VeroE6 cells.Sep 15, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : bioRxiv. 2020 Sep 16. Epub 2020 Sep 16. PMID: 32995771
Article Published Date : Sep 15, 2020
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Bromelain may have anti-skin tumor activity. Jan 01, 2008

Pubmed Data : Toxicol Appl Pharmacol. 2008 Jan 1;226(1):30-7. Epub 2007 Aug 23. PMID: 17889918
Article Published Date : Jan 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Skin Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Bromelain may have therapeutic value in the treatment of irritable bowel syndrome. Mar 01, 2008

Pubmed Data : Clin Immunol. 2008 Mar;126(3):345-52. Epub 2007 Dec 21. PMID: 18160345
Article Published Date : Mar 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Bromelain may stimulate type 1 cells up-regulating both innate as well as the adaptive immune system.Aug 17, 2005

Pubmed Data : Eur J Med Res. 2005 Aug 17;10(8):325-31. PMID: 16131473
Article Published Date : Aug 17, 2005
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Immune Disorders
Pharmacological Actions : Antiproliferative , Immunostimulatory
[+]

Bromelain reduces platelet aggregation and inhibits thrombus formation.Jan 01, 1999

Pubmed Data : In Vivo. 1999 Jan-Feb;13(1):7-12. PMID: 10218125
Article Published Date : Jan 01, 1999
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Thrombosis
Pharmacological Actions : Anti-Platelet, Thrombolytic
[+]

Bromelain supplementation and inflammatory markers.May 31, 2023

Pubmed Data : Clin Nutr ESPEN. 2023 Jun ;55:116-127. Epub 2023 Mar 2. PMID: 37202035
Article Published Date : May 31, 2023
Study Type : Review
Additional Links
Substances : Bromelain
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Bromelain treatment could potentiate the antitumor effect of cisplatin on triple-negative breast cancer 4T1 cells.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Cancer Ther. 2019 Jan-Dec;18:1534735419880258. PMID: 31752555
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Breast Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-4 downregulation
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Bromelain-cisplatin chemoherbal combination demonstrated synergistic in-vitro anticancer effect on human prostatic carcinoma cell line.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Galen Med J. 2020 ;9:e1749. Epub 2020 Aug 29. PMID: 34466585
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer
[+]

Bromelain: a review of its mechanisms, pharmacological effects and potential applications.Aug 30, 2023

Pubmed Data : Food Funct. 2023 Aug 31. Epub 2023 Aug 31. PMID: 37650738
Article Published Date : Aug 30, 2023
Study Type : Review
Additional Links
Substances : Bromelain
Diseases : Asthma, Inflammation, Osteoarthritis, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Bromelain: A review on its potential as a therapy for the management of Covid-19.Jan 29, 2020

Pubmed Data : Niger J Physiol Sci. 2020 06 30 ;35(1):10-19. Epub 2020 Jun 30. PMID: 33084621
Article Published Date : Jan 29, 2020
Study Type : Review
Additional Links
Substances : Bromelain
Diseases : Coronavirus Infection
Pharmacological Actions : Anti-Inflammatory Agents, Anticoagulants
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Cross-linked bromelain inhibits lipopolysaccharide-induced inflammation. Mar 22, 2006

Pubmed Data : J Agric Food Chem. 2006 Mar 22;54(6):2193-8. PMID: 16536595
Article Published Date : Mar 22, 2006
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Cytotoxic effect of bromelain on HepG2 hepatocellular carcinoma cell line. Mar 17, 2021

Pubmed Data : Appl Biochem Biotechnol. 2021 Mar 18. Epub 2021 Mar 18. PMID: 33735410
Article Published Date : Mar 17, 2021
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic
[+]

Enhancing the potency of chemotherapeutic agents by combination with bromelain and N-acetylcysteine.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2020 ;12(11):7404-7419. Epub 2020 Nov 15. PMID: 33312377
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, NAC (N-acetyl-L-cysteine)
Diseases : Liver Cancer, Pancreatic Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Doxorubicin, Chemotherapeutic Synergy: Gemcitabine
[+]

Evaluation of the radiosensitizing potency of bromelain for radiation therapy of 4T1 breast cancer cells.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Signals Sens. 2019 Jan-Mar;9(1):68-74. PMID: 30967992
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Radiosensitizer
[+]

Herbal anti-inflammatory agents for skin disease.Jan 01, 2000

Pubmed Data : Skin Therapy Lett. 2000 ;5(4):3-5. PMID: 10785407
Article Published Date : Jan 01, 2000
Study Type : Review
Additional Links
Substances : Bromelain, Capsaicin, Turmeric
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Naturally occurring immunomodulators with antitumor activity.Aug 31, 2017

Pubmed Data : Int Immunopharmacol. 2017 Sep ;50:291-304. PMID: 28734166
Article Published Date : Aug 31, 2017
Study Type : Review
Additional Links
Substances : Betulinic acid, Bromelain, Curcumin, Genistein, Resveratrol, Zerumbone
Diseases : Cancers: All
Pharmacological Actions : Antineoplastic Agents, Immunomodulatory
[+]

Neuroprotective effect of bromelain in 6-hydroxydopamine induced in vitro model of Parkinson's disease.Nov 30, 2021

Pubmed Data : Mol Biol Rep. 2021 Dec ;48(12):7711-7717. Epub 2021 Oct 13. PMID: 34643923
Article Published Date : Nov 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Papain and bromelain have an antibacterial effect on A. acidoterrestris.Jan 03, 2016

Pubmed Data : Int J Food Microbiol. 2016 Jan 4 ;216:121-6. Epub 2015 Oct 8. PMID: 26476327
Article Published Date : Jan 03, 2016
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, Papain
Diseases : Gram-Positive Bacterial Infections
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance Synergy
[+]

Pineapple bromelain induces apoptosis in mammary cancer cells.Sep 16, 2010

Pubmed Data : Biofactors. 2010 Sep 16. Epub 2010 Sep 16. PMID: 20848558
Article Published Date : Sep 16, 2010
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, Pineapple
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
Additional Keywords : Autophagy
[+]

Radiosensitizing effect of bromelain.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Cancer Ther. 2021 Jan-Dec;20:15347354211060369. PMID: 34825602
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Cancers: All
Pharmacological Actions : NF-kappaB Inhibitor, Radiosensitizer
[+]

Results demonstrate that bacterial nanocellulose could improve bromelain antimicrobial activity 9 times.Dec 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Dec 21 ;7(1):18031. Epub 2017 Dec 21. PMID: 29269741
Article Published Date : Dec 20, 2017
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Pharmacological Actions : Antimicrobial, Antioxidants
[+]

Review: Bromelain's anti-cancer potential. Apr 28, 2010

Pubmed Data : Cancer Lett. 2010 Apr 28;290(2):148-56. Epub 2009 Aug 22. PMID: 19700238
Article Published Date : Apr 28, 2010
Study Type : Review
Additional Links
Substances : Bromelain
Diseases : Cancers: All
Pharmacological Actions : Antineoplastic Agents
[+]

The benefit of combining curcumin, bromelain and harpagophytum to reduce inflammation in osteoarthritic synovial cells.Oct 13, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2021 Oct 14 ;21(1):261. Epub 2021 Oct 14. PMID: 34649531
Article Published Date : Oct 13, 2021
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, Curcumin
Diseases : Inflammation, Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Plant Extracts
[+]

The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Metabol Open. 2020 Dec ;8:100066. Epub 2020 Nov 13. PMID: 33205039
Article Published Date : Nov 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, Curcumin
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents, Immunostimulatory
Additional Keywords : Natural Substance Synergy
[+]

The combination of bromelain and dexamethasone sodium phosphate induced a great activation of mesenchymal stem cells.May 31, 2019

Pubmed Data : J Craniofac Surg. 2019 Jun ;30(4):1064-1067. PMID: 30358745
Article Published Date : May 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Wound Healing
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Mesenchymal Stem Cells, Natural Substance/Drug Synergy
Problem Substances : Dexamethasone
[+]

The current review describes the promising clinical applications and therapeutic properties of bromelain.Aug 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Rep. 2016 Sep ;5(3):283-288. Epub 2016 Jul 18. PMID: 27602208
Article Published Date : Aug 31, 2016
Study Type : Review
Additional Links
Substances : Bromelain
Diseases : Cancers: All, Cholera, Escherichia coli Infections, Inflammation, Wound Healing
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Anti-thrombotic, Antifibrinolytic Agents, Chemopreventive, Immunomodulatory
[+]

The potential use of bromelain as a natural oral medicine having anticarcinogenic activities.Apr 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Sci Nutr. 2019 May ;7(5):1656-1667. Epub 2019 Apr 1. PMID: 31139378
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Oral Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative
[+]

This finding indicated that bromelain could have an inhibitory effect on different SARS-CoV-2 variants.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:717757. Epub 2021 Aug 20. PMID: 34489706
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents

Copyright: alex9500 / 123RF Stock Photo

Bromelain Related Articles

Pineapple's Amazing Healing Properties Revealed
Written by Sayer Ji, Founder
Enjoyed the world over as something of an icon of the tropical experience, the pineapple was used in indigenous medicine for a wide range of ailments; uses that are only now being confirmed by modern scientific methods.
Natural Solutions to Computer-Induced Problems
Written by Linda Woolven & Ted Snider
As more and more people are spending more and more time on computers, we are developing more and more computer induced problems. But there are ancient, natural solutions to these modern, technological problems.
Top 10 Natural Cough and Lung Remedies
Written by GreenMedInfo Research Group
If you're feeling a tell-tale tickle in your throat that signifies a cough may be coming on, it's time to stock up on the top 10 natural cough and lung remedies. You don't need narcotic syrups or prescription medicines to start breathing easier today
Research: Pineapple Enzyme Kills Cancer Without Killing You
Written by Sayer Ji, Founder
Could an extract of pineapple fruit be both safer and more effective than a blockbuster chemotherapy agent?
Protect Your Bones With 8 Natural Osteoprotectives
Written by Dr. Diane Fulton
Your bones support your entire body. Isn’t it time to find natural alternatives to strengthen them?
Studies Show Serrapeptase Works Better than Steroids in Oral Surgery
Written by Dr. Michael Murray
Enzyme preparations are one of nature’s most powerful therapeutic agents - particularly, the proteolytic enzyme serrapeptase or the “silk worm” enzyme
Research: Antibiotics Will Not Help Your Sinuses
Written by Dr. Peter Braglia
Sinus infections are the fifth most common reason antibiotics are prescribed for adults. Unfortunately, they are of no help for most sinus infections – this according to a new study published in the Journal of the American Medical Association (JAMA)
Study: Knee Surgery No Better Than Placebo
Written by Margie King, Health Coach
Surgery probably won’t help you with chronic knee pain. But here are 10 proven ways to get you safely back in the swing of things.
Boswellia Serrata and Bromelain Extracts Useful in Mitigating Osteoarthritis Symptoms
Written by GreenMedInfo Research Group
Researchers find Boswellia serrata and bromelain extracts as safe and effective tools for reducing pain and inflammation in arthritis patients

Print Options

Some features are currently member only features. If you are already a member, please login. Otherwise, click here to become a member.
  • Printer-friendly version

Connect with GreenMedInfo

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.