Bupleurum

Name	AC	CK
Depression	20	38
Lung Cancer	3	13
Inflammation	6	11
Lipopolysaccharide-Induced Toxicity	5	11
Nonalcoholic fatty liver disease (NAFLD)	5	10
Liver Cancer	6	9
Liver Fibrosis	4	8
Cancers: Drug Resistant	4	7
Gastric Cancer	6	7
Obesity	4	7
Oxidative Stress	3	7
Brain Inflammation	3	6
Brain: Microglial Activation	3	6
Breast Cancer	4	6
Chronic Kidney Disease (CKD)	3	6
Fatty Liver	3	6
Bladder Cancer	2	5
Cancers: All	3	5
Pancreatic Cancer	4	5
Alcoholic Liver Disease	2	4
Alzheimer's Disease	2	4
Lung Damage	2	4
Osteoarthritis	2	4
Pancreatitis	2	4
Prostate Cancer	2	4
Sepsis	3	4
Breast Cancer: Triple Negative	2	3
Chemotherapy-Induced Toxicity: Doxorubicin	1	3
Glioblastoma	2	3
Hashimoto's thyroiditis	1	3
Thyroid Cancer	1	3
Alcohol Toxicity	1	2
Allergic Rhinitis	1	2
Asthma	1	2
Atopic Dermatitis	1	2
Cachexia: Cancer	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Bleomycin	1	2
Chemotherapy-Induced Toxicity: Irinotecan	1	2
Cholangiocarcinoma	2	2
Chronic Pelvic Pain Syndrome	1	2
Circadian Dysregulation	1	2
Colorectal Cancer	1	2
Diabetic Neuropathy	1	2
Dry Eye Syndromes	1	2
Dyspepsia	1	2
Endometrial Cancer	1	2
Fibrosis: Liver	1	2
Hyperlipidemia	1	2
Insulin Resistance	1	2
Kidney Damage: Drug-Induced	1	2
Kidney Failure	1	2
Kidney Fibrosis	1	2
Liver Damage	1	2
Liver Damage: Aflatoxin-Induced	1	2
Liver Disease	1	2
Liver Injury: Ischemia/reperfusion	1	2
Lupus Erythematosus: Systemic	1	2
Mastitis	1	2
Medulloblastoma	1	2
Muscle Atrophy	1	2
Osteoporosis	1	2
Otitis media	1	2
Parkinson's Disease	1	2
Post-Traumatic Stress Disorders (PTSD)	1	2
Prostatitis: Chronic	1	2
Psoriasis	1	2
Pulmonary Fibrosis	1	2
Retroperitoneal Fibrosis	1	2
Schizophrenia	1	2
Skin Diseases: Inflammatory	1	2
Staphylococcus aureus infection	1	2
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	2
Trigeminal Neuralgia	1	2
Ulcerative Colitis	1	2
Carcinoma: Non-Small-Cell Lung	1	1
Esophageal Cancer	1	1
High Fat Diet	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Liver Diseases	1	1
Mycobacterium Tuberculosis	1	1
Myocardial Ischemia	1	1
Neuroblastoma	1	1
Seizures	1	1

Name	AC	CK
Anti-Inflammatory Agents	34	65
Antiproliferative	26	47
Apoptotic	27	41
Antidepressive Agents	18	36
NF-kappaB Inhibitor	13	26
Hepatoprotective	13	24
Tumor Necrosis Factor (TNF) Alpha Inhibitor	11	22
Antioxidants	9	17
Gastrointestinal Agents	7	14
Interleukin-6 Downregulation	7	14
Anti-Apoptotic	7	13
Interleukin-1 beta downregulation	7	13
Anti-Fibrotic	6	12
Anti-metastatic	6	9
Chemosensitizer	5	8
Hypolipidemic	5	8
Immunomodulatory	5	8
Chemoprotective Agents	3	7
Neuroprotective Agents	4	7
Autophagy Up-regulation	4	6
Cardioprotective	3	6
Nrf2 activation	3	6
Antineoplastic Agents	3	4
Chemotherapeutic	2	4
Fibroblast growth factor 21 upregulation	2	4
Heme oxygenase-1 up-regulation	2	4
Pancreato Protective Agents	2	4
Renoprotective	2	4
Cell cycle arrest	2	3
Analgesics	1	2
Angiogenesis Inhibitors	1	2
Anti-Asthmatic Agents	1	2
Anti-Bacterial Agents	1	2
Anti-Cachexic Agents	1	2
Anticholesteremic Agents	1	2
Brain-derived neurotrophic factor modulator	1	2
Gastroprotective	1	2
Interleukin-17 downregulation	1	2
Interleukin-4 downregulation	1	2
Interleukin-5 downregulation	1	2
Neurogenesis	1	2
Osteoprotective	1	2
Radiosensitizer	2	2
SIRT1 Activator	1	2
Vascular Endothelial Growth Factor Inhibitors	1	2
Interleukin-18 down-regulation	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1

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Mechanism of Saikosaponin D in regulating ferroptosis in patient-derived lung adenocarcinoma organoids.Jan 30, 2026

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Pubmed Data : Sci Rep. 2026 Jan 31 ;16(1):2513. Epub 2026 Jan 31. PMID: 41620478

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Pubmed Data : Cancer Lett. 2023 Feb 1 ;554:216011. Epub 2022 Nov 26. PMID: 36442771

Article Published Date : Jan 31, 2023

Study Type : Animal Study, In Vitro Study

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Substances : Bupleurum

Diseases : Prostate Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Chemotherapeutic Synergy: Docetaxel

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Saikosaponin A inhibits growth of human bladder carcinoma T24 and 5637 cells.Jun 30, 2022

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Pubmed Data : J Immunol Res. 2022 ;2022:7455494. Epub 2022 Nov 8. PMID: 36398316

Article Published Date : Dec 31, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Bupleurum

Diseases : Hashimoto's thyroiditis

Pharmacological Actions : Immunomodulatory

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Saikosaponin‑D triggers cancer cell death by targeting the PIM1/c-Myc axis to reprogram oncogenic alternative splicing.Oct 05, 2025

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Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2021 Aug ;46(16):4222-4229. PMID: 34467736

Article Published Date : Jul 31, 2021

Study Type : Animal Study

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Substances : Bupleurum

Diseases : Depression

Pharmacological Actions : Antidepressive Agents, Gastrointestinal Agents

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Effects of saikosaponin D on apoptosis, autophagy, and morphological structure of intestinal cells of cajal with functional dyspepsia.Dec 31, 2023

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Saikogenin A improves ethanol-induced liver injury by targeting SIRT1 to modulate lipid metabolism.Nov 20, 2024

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Pubmed Data : J Cell Mol Med. 2023 Nov ;27(22):3443-3450. Epub 2023 Aug 29. PMID: 37644785

Article Published Date : Oct 31, 2023

Study Type : Animal Study

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Substances : Bupleurum

Diseases : Inflammation, Mastitis, Staphylococcus aureus infection

Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation, SIRT1 Activator

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Saikosaponin a ameliorates diet-induced fatty liver.Nov 30, 2023

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Pubmed Data : Molecules. 2023 Jan 18 ;28(3). Epub 2023 Jan 18. PMID: 36770631

Article Published Date : Jan 17, 2023

Study Type : Animal Study

Additional Links

Substances : Bupleurum

Diseases : Lipopolysaccharide-Induced Toxicity, Lung Damage

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Saikosaponin A and saikosaponin C reduce TNF-α-induced TSLP expression.Apr 26, 2022

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Pubmed Data : J Ethnopharmacol. 2025 Sep 25 ;353(Pt A):120283. Epub 2025 Jul 12. PMID: 40659145

Article Published Date : Sep 24, 2025

Study Type : Animal Study

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Substances : Bupleurum

Diseases : Chronic Kidney Disease (CKD)

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Saikosaponin C ameliorates tau-related pathology by modulating oxidative stress and MAPK axis in Alzheimer's disease.Aug 28, 2025

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Pubmed Data : J Orthop Surg Res. 2024 Feb 22 ;19(1):151. Epub 2024 Feb 22. PMID: 38389105

Article Published Date : Feb 21, 2024

Study Type : Animal Study

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Substances : Bupleurum

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents

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Saikosaponin d alleviates liver fibrosis.Dec 31, 2021

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Pubmed Data : Oncol Rep. 2026 Feb ;55(2). Epub 2025 Dec 5. PMID: 41347830

Article Published Date : Jan 31, 2026

Study Type : Animal Study

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Substances : Bupleurum

Diseases : Cancers: Drug Resistant, Pancreatic Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Chemotherapeutic Synergy: Gemcitabine

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Saikosaponin D protects against isoproterenol-induced kidney injury in rats by regulating the intrarenal renin-angiotensin system.Mar 26, 2026

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Pubmed Data : Toxicol Appl Pharmacol. 2026 Mar 27 ;511:117802. Epub 2026 Mar 27. PMID: 41903810

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Pubmed Data : Brain Res Bull. 2020 Apr ;157:69-76. Epub 2020 Jan 8. PMID: 31926302

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Pubmed Data : Pharmacol Rep. 2024 Aug ;76(4):780-792. Epub 2024 Jul 4. PMID: 38965200

Article Published Date : Jul 31, 2024

Study Type : Review

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Substances : Bupleurum

Diseases : Cancers: All

Pharmacological Actions : Antiproliferative , Apoptotic

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aikosaponin A and D inhibit adipogenesis.Oct 21, 2021

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Pubmed Data : Int J Mol Sci. 2021 Oct 22 ;22(21). Epub 2021 Oct 22. PMID: 34768840

Article Published Date : Oct 21, 2021

Study Type : In Vitro Study

Additional Links

Substances : Bupleurum

Diseases : Obesity

Additional Keywords : Anti-Obesity Agents, Plant Extracts

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Antitumor effect of saikosaponin A on human neuroblastoma cells.Dec 31, 2020

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Pubmed Data : BMC Complement Med Ther. 2024 Oct 1 ;24(1):347. Epub 2024 Oct 1. PMID: 39354431

Article Published Date : Sep 30, 2024

Study Type : In Vitro Study

Additional Links

Substances : Bupleurum

Diseases : Sepsis

Pharmacological Actions : Immunomodulatory

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Mechanism of saikogenin G against major depressive disorder determined by network pharmacology.Aug 25, 2022

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Saikosaponin A targets HDAC6 to inhibit Mycobacterium tuberculosis-induced macrophage Pyroptosis.Jun 30, 2025

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Pubmed Data : Phytomedicine. 2026 Apr ;153:157993. Epub 2026 Feb 21. PMID: 41759425

Article Published Date : Mar 31, 2026

Study Type : In Vitro Study

Additional Links

Substances : Bupleurum

Diseases : Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Saikosaponin D mitigates radioresistance in triple-negative breast cancer.Dec 31, 2024

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Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2023 Jul 25 ;55(9):1404-1414. PMID: 37489008

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View the Evidence: 128 Abstracts with Bupleurum Research

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Mechanism of Saikosaponin D in regulating ferroptosis in patient-derived lung adenocarcinoma organoids.Jan 30, 2026

Antitumor mechanism of Saikosaponin A in the Xiaoying Sanjie Decoction for treatment of anaplastic thyroid cancer.Sep 30, 2023

Multifunctional saikosaponin D-liposomes for hepatocellular carcinoma.Nov 30, 2025

Saikosaponin A enhances Docetaxel efficacy by selectively inducing death of dormant prostate cancer cells through excessive autophagy.Jan 31, 2023

Saikosaponin A inhibits growth of human bladder carcinoma T24 and 5637 cells.Jun 30, 2022

Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress.Nov 14, 2023

Saikosaponin D attenuates pancreatic injury.Dec 31, 2020

Saikosaponin D efficiently protected the cardiomyocytes from doxorubicin-induced cardiotoxicity.Mar 31, 2022

Saikosaponin D potentiates the antineoplastic effects of doxorubicin in drug-resistant breast cancer.Sep 30, 2024

Saikosaponin-d attenuates Hashimoto's thyroiditis by regulating macrophage polarization.Dec 31, 2021

Saikosaponin‑D triggers cancer cell death by targeting the PIM1/c-Myc axis to reprogram oncogenic alternative splicing.Oct 05, 2025

Anti-depressant mechanism of Bupleuri Radix in regulating hippocampal FGFR1-5-HT_(1A)R heterodimer formation.Nov 30, 2025

Antidepressant effect of Radix bupleuri - Radix paeoniae alba herb pair on chronic unpredictable mild stress rats.May 09, 2025

Bupleuri radix extract ameliorates impaired lipid metabolism in high-fat diet-induced obese mice.Feb 28, 2021

Bupleuri radix polysaccharides alleviate MASLD.Jan 07, 2026

Bupleuri Radix polysaccharides enhance the efficacy and intestinal absorption of baicalin.Aug 31, 2025

Bupleurum chinense DC. ameliorates depression through hepatic lipopolysaccharide-binding protein-associated inflammation and monoamine biosynthesis.Jun 11, 2026

Bupleurum chinense DC. reduces LPS-induced neuroinflammation.Feb 27, 2026

Bupleurum polysaccharides have a beneficial effect on system lupus erythematosus-like syndrome in a mouse experimental model. Feb 01, 2005

Curcumin (from turmeric) and saikosaponin (from Bupleurum) protects against chemically induced liver fibrosis. Jun 01, 2008

Development of saikosaponin D liposome nanocarrier with increased hepatoprotective effect against alcoholic hepatitis.Mar 31, 2021

Effects of Bupleurum chinense on the diversity of intestinal flora in depressed mice.Jul 31, 2021

Effects of saikosaponin D on apoptosis, autophagy, and morphological structure of intestinal cells of cajal with functional dyspepsia.Dec 31, 2023

Effects of saikosaponin-A on insulin resistance in obesity.Dec 31, 2023

Hepatoprotective effects of Radix Bupleuri extract on aflatoxin B1-induced liver injury.Sep 14, 2024

Immunomodulatory mechanism of Radix Bupleuri polysaccharide on RAW264.7 cells and cyclophosphamide-induced immunosuppressed mice.Sep 30, 2025

Inhibition of IL-6 methylation by Saikosaponin C regulates neuroinflammation to alleviate depression.Apr 30, 2023

Integrated metabolomic and transcriptomic analyses reveal Radix Bupleuri alleviates MASLD.May 22, 2026

Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease.Oct 31, 2021

Integrative transcriptomics and lipidomics unravels the amelioration effects of Radix Bupleuri on non-alcoholic fatty liver disease.Feb 09, 2025

Low polarity fraction of Radix Bupleuri alleviates chronic unpredictable mild stress-induced depression.Jan 14, 2025

Mechanism analysis of essential oil from Radix Bupleuri for the treatment of asthma through regulation of ectopic olfactory receptor.Nov 14, 2024

Potential targets and mechanisms of saikosaponin D in psoriasis.Dec 31, 2024

Protective effect of Saikosaponin D modulating endoplasmic reticulum stress mediated by TLR4/MyD88/NF-κB/NLRP3 pathway on cholestatic liver injury.Apr 10, 2026

Radix Bupleuri aqueous extract attenuates MK801-induced schizophrenia-like symptoms.Feb 29, 2024

Saikogenin A improves ethanol-induced liver injury by targeting SIRT1 to modulate lipid metabolism.Nov 20, 2024

Saikosaponin a activates tet1/dll3/notch1 signalling and promotes hippocampal neurogenesis to improve depression-like behavior.Jan 29, 2024

Saikosaponin A alleviates depressive-like behavior.Dec 31, 2024

Saikosaponin A alleviates Staphylococcus aureus-induced mastitis.Oct 31, 2023

Saikosaponin a ameliorates diet-induced fatty liver.Nov 30, 2023

Saikosaponin A ameliorates ulcerative colitis by targeting the CH25H/25-OHC axis to inhibit NLRP3 inflammasome in macrophages.Jul 24, 2025

Saikosaponin A and D attenuate skeletal muscle atrophy in chronic kidney disease.May 31, 2023

Saikosaponin A and its epimers alleviate LPS-induced acute lung injury.Jan 17, 2023

Saikosaponin A and saikosaponin C reduce TNF-α-induced TSLP expression.Apr 26, 2022

Saikosaponin A attenuates obesity and promotes browning of white adipose tissue.Mar 31, 2026

Saikosaponin A is a promising candidate for PTSD treatment.Feb 27, 2026

Saikosaponin A mitigates the progression of Parkinson's disease.Jul 31, 2023

Saikosaponin A recovers impaired filaggrin levels in inflamed skin.Aug 26, 2024

Saikosaponin antidepressant mechanism: Improving the sphingolipid metabolism in the cortex via Apolipoprotein E and triggering neurovascular coupling.Aug 31, 2024

Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma.May 31, 2022

Saikosaponin B2 improves depressive behavior of VaD mice by promoting oligodendrocyte maturation via regulating Akt/mTOR pathway.Jan 31, 2026

Saikosaponin b2 inhibits tumor angiogenesis in liver cancer.Jun 30, 2023

Saikosaponin C ameliorates renal injury and fibrosis.Sep 24, 2025

Saikosaponin C ameliorates tau-related pathology by modulating oxidative stress and MAPK axis in Alzheimer's disease.Aug 28, 2025

Saikosaponin d (SSD) alleviates diabetic peripheral neuropathy.May 31, 2023

Saikosaponin D alleviates cancer cachexia by directly inhibiting STAT3.Feb 28, 2023

Saikosaponin D alleviates chronic prostatitis/chronic pelvic pain syndrome.May 22, 2026

Saikosaponin D alleviates inflammatory response of osteoarthritis.Feb 21, 2024

Saikosaponin d alleviates liver fibrosis.Dec 31, 2021

Saikosaponin D alleviates liver ischemia-reperfusion injury.Apr 11, 2026

Saikosaponin D ameliorates sepsis-induced acute lung injury.Mar 31, 2025

Saikosaponin D attenuates metabolic associated fatty liver disease.Jul 31, 2022

Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress.May 23, 2022

Saikosaponin D exerts cytotoxicity on human endometrial cancer ishikawa cells by inducing apoptosis and inhibiting metastasis through MAPK pathways.Jun 30, 2023

Saikosaponin D from Bupleurum targets SaeR to disrupt biofilm formation and pathogenic programs for the treatment of MRSA pneumonia.Feb 28, 2026

Saikosaponin D improves chemosensitivity of glioblastoma by reducing the its stemness maintenance.Nov 30, 2022

Saikosaponin D inhibited IL-1β induced ATDC 5 chondrocytes apoptosis.Dec 31, 2021

Saikosaponin D inhibited osteoclastogenesis and LPS-induced osteolysis.Dec 31, 2020

Saikosaponin D inhibits bladder cancer growth and enhances the synergistic antitumor effect of gemcitabine.Jun 03, 2026

Saikosaponin D inhibits lung metastasis of colorectal cancer cells.Jun 11, 2024

Saikosaponin D inhibits peritoneal fibrosis in rats with renal failure.Dec 31, 2020

Saikosaponin D inhibits the inflammatory response of secretory otitis media.Apr 09, 2025

Bupleurum

View the Evidence:
128 Abstracts with Bupleurum Research