Burdock

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103 Diseases Researched for Burdock
NameACCKFocus
Inflammation1022Locked
Obesity518Locked
Cancers: Drug Resistant312Locked
Acne110Locked
Atherosclerosis510Locked
C-Reactive Protein110Locked
Helicobacter Pylori Infection110Locked
Metabolic Syndrome X110Locked
Osteoarthritis110Locked
Pancreatic Cancer110Locked
Chemically-Induced Liver Damage48Locked
Breast Cancer77Locked
Diabetes Mellitus: Type 247Locked
Colitis36Locked
Hyperlipidemia36Locked
Oxidative Stress56Locked
Acetaminophen (Tylenol) Toxicity 35Locked
Breast Cancer: Triple Negative 45Locked
Lipopolysaccharide-Induced Toxicity35Locked
Alcohol Toxicity 24Locked
Alzheimer's Disease34Locked
Brain Inflammation 24Locked
Depression24Locked
Gastric Ulcer24Locked
High Fat Diet24Locked
Allergies33Locked
Cadmium Poisoning 23Locked
Cerebral Ischemia23Locked
Diabetic Retinopathy23Locked
Liver Cancer23Locked
Liver Damage13Locked
Toxoplasma gondii Infection13Locked
Aging12Locked
Allodynia12Locked
Amyotrophic Lateral Sclerosis12Locked
Animal Diseases: Porcine Circovirus Type 2 (PCV2) 12Locked
Autoimmune Diseases12Locked
Cachexia: Cancer12Locked
Candida Albicans22Locked
Cardiac Hypertrophy12Locked
Chemotherapy-Induced Toxicity: Mitomycin-C12Locked
Colon Cancer22Locked
Colorectal Cancer22Locked
Constipation12Locked
DNA damage12Locked
Diabetes: Cognitive Dysfunction12Locked
Diabetic Complications12Locked
Escherichia coli Infections22Locked
Fatigue12Locked
Gastrointestinal Inflammation12Locked
Gout12Locked
Hypoglycemia12Locked
Infertility: Male12Locked
Inflammatory Bowel Diseases12Locked
Leukemia22Locked
Liver Steatosis12Locked
Lung Injury: Acute12Locked
Macular Degeneration12Locked
Melanoma12Locked
Multiple Myeloma22Locked
Multiple Sclerosis12Locked
Myocardial Ischemia12Locked
Nonalcoholic fatty liver disease (NAFLD)12Locked
Preneoplastic Conditions12Locked
Stroke12Locked
Testicular Injury: Chemical/Metal Induced12Locked
Acute T cell Leukemias11Locked
Bladder Stones11Locked
Cachexia11Locked
Cancer Metastasis11Locked
Cancers: All11Locked
Cancers: Multi-Drug Resistant11Locked
Cervical Cancer11Locked
Coronavirus Infection11Locked
Dermatitis: Contact11Locked
Diabetes: Oxidative Stress11Locked
Diabetic Nephropathy11Locked
Dysbiosis11Locked
Enterococcus Infections11Locked
Foodborne Pathogens: Prevention/Food Preservation11Locked
Herpes Simplex Virus Type 111Locked
Hydrogen Peroxide Induced Toxicity11Locked
Hyperglycemia11Locked
Kidney Stones11Locked
Klebsiella Infections11Locked
Liver Cirrhosis11Locked
Lung Cancer11Locked
Muscular Dystrophies11Locked
Mycobacterium Tuberculosis11Locked
Neurodegenerative Diseases11Locked
Osteoporosis11Locked
Parasitic Diseases11Locked
Peritonitis11Locked
Promyelocytic leukemia 11Locked
Prostate Cancer11Locked
Pseudomonas aeruginosa11Locked
Sarcopenia11Locked
Staphylococcus aureus infection11Locked
Steptococcus Mutans Infections11Locked
Streptococcus Infections11Locked
Ultraviolet Radiation Induced Damage11Locked
Urolithiasis11Locked
Aging Skin10Locked
68 Pharmacological Actions Researched for Burdock
NameACCKFocus
Anti-Inflammatory Agents3268Locked
Antioxidants1743Locked
Interleukin-6 Downregulation1129Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor1425Locked
Hepatoprotective1020Locked
Neuroprotective Agents1116Locked
Anti-Bacterial Agents615Locked
Hypolipidemic815Locked
Interleukin-1 beta downregulation815Locked
Antiproliferative 1314Locked
Anti-Apoptotic612Locked
Apoptotic910Locked
NF-kappaB Inhibitor69Locked
Gastrointestinal Agents48Locked
Anticholesteremic Agents36Locked
Cardioprotective36Locked
Hypoglycemic Agents46Locked
Immunomodulatory35Locked
Anti-metastatic44Locked
Chemopreventive44Locked
Chemotherapeutic34Locked
Immunomodulatory: Th17 downregulation24Locked
Anti-Allergic Agents33Locked
Anti-Fibrotic23Locked
Antiviral Agents23Locked
Autophagy Up-regulation23Locked
Renoprotective23Locked
STAT3 Inhibitor23Locked
Angiogenesis Inhibitors22Locked
Anti-Cachexic Agents12Locked
Anti-Ulcer Agents12Locked
Anticarcinogenic Agents12Locked
Antidepressive Agents12Locked
Antimutagenic Agents12Locked
Antinoceceptive 12Locked
Bax/Bcl2 ratio: Increase22Locked
Cell cycle arrest22Locked
Chemoprotective Agents12Locked
Cyclooxygenase 2 Inhibitors12Locked
Fertility Agents: Male12Locked
Gastroprotective12Locked
Genoprotective12Locked
Heme oxygenase-1 up-regulation22Locked
Immunosuppressive Agents12Locked
Interleukin-10 downregulation12Locked
Interleukin-10 upregulation12Locked
Interleukin-4 downregulation22Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor22Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor22Locked
Nrf2 activation22Locked
STAT3 Activation12Locked
Transforming growth factor beta (TGF-β) upregulation12Locked
Vascular Endothelial Growth Factor Inhibitors12Locked
Alpha-amylase inhibitor11Locked
Anti-Angiogenic11Locked
Antifungal Agents11Locked
Antimicrobial11Locked
Antiparasitic Agents11Locked
Aphrodisiac 11Locked
Chemosensitizer11Locked
Histamine down-regulation11Locked
Interleukin-5 downregulation11Locked
Multidrug Resistance Gene Modulators11Locked
Osteoprotective 11Locked
Photoprotective11Locked
Prostaglandin PGE2 downregulation11Locked
Superoxide Dismutase Up-regulation11Locked
Wnt/β-catenin signaling pathway modulation11Locked

View the Evidence:
114 Abstracts with Burdock Research

[+]

Anti-acne action of peptides isolated from burdock root-preliminary studies and pilot testing.Apr 26, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Apr 27 ;25(9). Epub 2020 Apr 27. PMID: 32349230
Article Published Date : Apr 26, 2020
Study Type : Human Study
Additional Links
Substances : Burdock
Diseases : Acne
Pharmacological Actions : Anti-Bacterial Agents
[+]

Burdock complex could attenuate H. pylori infection by inhibiting adhesion and subsequent inflammatory response on the gastric epithelial cells.Mar 07, 2018

Pubmed Data : Helicobacter. 2018 Mar 8. Epub 2018 Mar 8. PMID: 29520881
Article Published Date : Mar 07, 2018
Study Type : Human Study
Additional Links
Substances : Burdock
Diseases : Helicobacter Pylori Infection
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Burdock root tea improves inflammatory status and oxidative stress in patients with knee osteoarthritis.Oct 27, 2014

Pubmed Data : Int J Rheum Dis. 2014 Oct 28. Epub 2014 Oct 28. PMID: 25350500
Article Published Date : Oct 27, 2014
Study Type : Human Study
Additional Links
Substances : Burdock
Diseases : C-Reactive Protein, Inflammation, Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation
[+]

Exercise training and burdock root extract independently improve abdominal obesity and sex hormones.Mar 03, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2021 Mar 4 ;11(1):5175. Epub 2021 Mar 4. PMID: 33664334
Article Published Date : Mar 03, 2021
Study Type : Human Study
Additional Links
Substances : Burdock
Diseases : Metabolic Syndrome X, Obesity
Therapeutic Actions : Exercise
Additional Keywords : Anti-Obesity Agents
[+]

Of the 15 patients, 1 showed confirmed partial response and 4 patients had stable disease.Sep 28, 2016

Pubmed Data : Cancer Sci. 2016 Sep 29. Epub 2016 Sep 29. PMID: 27685612
Article Published Date : Sep 28, 2016
Study Type : Human Study
Additional Links
Substances : Burdock
Diseases : Cancers: Drug Resistant, Pancreatic Cancer
Additional Keywords : Plant Extracts
[+]

Arctium lappa L. root polysaccharides ameliorate CCl4-induced acute liver injury.Oct 21, 2023

Pubmed Data : Nat Prod Res. 2023 Oct 22:1-6. Epub 2023 Oct 22. PMID: 37867310
Article Published Date : Oct 21, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Burdock
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Polysaccharides
[+]

Protective effect of arctiin against Toxoplasma gondii HSP70-induced allergic acute liver injury.Jan 04, 2024

Pubmed Data : Int Immunopharmacol. 2024 Jan 5 ;126:111254. Epub 2023 Nov 22. PMID: 37995571
Article Published Date : Jan 04, 2024
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Burdock, Lingans
Diseases : Liver Damage, Toxoplasma gondii Infection
Pharmacological Actions : Hepatoprotective
[+]

A. lappa root may have antiinfertility effects by increasing sperm count and, serum gonadotropin and testosterone levels of nondiabetic mice. Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Malays J Med Sci. 2015 Mar-Apr;22(2):25-32. PMID: 26023292
Article Published Date : Feb 28, 2015
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Diabetes Mellitus: Type 2, Infertility: Male
Pharmacological Actions : Fertility Agents: Male
Additional Keywords : Plant Extracts
[+]

A Burdock extract was able to reduce intestinal inflammation in an acute TNBS-induced experimental model of colitis in rats.Mar 06, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ethnopharmacol. 2013 Mar 7 ;146(1):300-10. Epub 2013 Jan 10. PMID: 23313393
Article Published Date : Mar 06, 2013
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Phytotherapy, Plant Extracts
[+]

A dicaffeoylquinic acid isomer from Arctium lappa has a potent anti-ulcer activity.Mar 31, 2015

Pubmed Data : Talanta. 2015 Apr ;135:50-7. Epub 2014 Dec 10. PMID: 25640125
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Alcohol Toxicity , Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents
Additional Keywords : Plant Extracts
[+]

A herbal preparation suppressed 80 % of DNA strand breaks in the liver, kidney, lung, brain and testicles of mice exposed to mitomycin C.Feb 09, 2015

Pubmed Data : J Nat Med. 2015 Feb 10. Epub 2015 Feb 10. PMID: 25666712
Article Published Date : Feb 09, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Barberry, Burdock, Dandelion
Diseases : Chemotherapy-Induced Toxicity: Mitomycin-C, DNA damage
Pharmacological Actions : Antimutagenic Agents
Additional Keywords : Drug: Mitomycin, Plant Extracts
[+]

A. lappa could protect the liver cells from carbon tetrachloride or acetaminophen-induced liver damages.Dec 31, 1999

Pubmed Data : Am J Chin Med. 2000 ;28(2):163-73. PMID: 10999435
Article Published Date : Dec 31, 1999
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

An ethanolic extract of Arctium lappa L. leaves ameliorates experimental atherosclerosis.May 09, 2024

Pubmed Data : J Ethnopharmacol. 2024 May 10 ;325:117768. Epub 2024 Jan 20. PMID: 38253275
Article Published Date : May 09, 2024
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Atherosclerosis, Stroke
Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Anti-inflammatory activity of alkali-soluble polysaccharides from Arctium lappa L. and its effect on gut microbiota of mice with inflammation.Mar 18, 2020

Pubmed Data : Int J Biol Macromol. 2020 Mar 19 ;154:773-787. Epub 2020 Mar 19. PMID: 32199919
Article Published Date : Mar 18, 2020
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Polysaccharides
[+]

Antidepressive effect of arctiin by attenuating neuroinflammation.Jan 04, 2020

Pubmed Data : ACS Chem Neurosci. 2020 08 5 ;11(15):2214-2230. Epub 2020 Jul 15. PMID: 32609480
Article Published Date : Jan 04, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Burdock
Diseases : Brain Inflammation , Depression
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Aqueous extract of burdock root reduced body weight and cholesterol in rats, possibly by modulating the differential expression of genes.Dec 31, 2016

Pubmed Data : J Int Med Res. 2017 Jan 1:300060517716341. Epub 2017 Jan 1. PMID: 28758851
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : High Fat Diet
Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic
Additional Keywords : Gene Expression Regulation
[+]

Arctigenin ameliorates colitis through down-regulating the differentiation of Th1 and Th17 cells via mTORC1 pathway. Aug 14, 2015

Pubmed Data : Biochem Pharmacol. 2015 Aug 15 ;96(4):323-36. Epub 2015 Jun 11. PMID: 26074264
Article Published Date : Aug 14, 2015
Study Type : Animal Study
Additional Links
Substances : Arctigenin, Burdock
Diseases : Colitis, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Immunomodulatory: Th17 downregulation
[+]

Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancerJan 02, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Jan 3 ;8(1):329-344. PMID: 27861147
Article Published Date : Jan 02, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Burdock
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic, STAT3 Inhibitor
[+]

Arctigenin may have anti-inflammatory and immunosuppressive properties via inhibiting Th17 cells.Oct 05, 2015

Pubmed Data : Mol Neurobiol. 2015 Oct 6. Epub 2015 Oct 6. PMID: 26440666
Article Published Date : Oct 05, 2015
Study Type : Animal Study
Additional Links
Substances : Arctigenin, Burdock
Diseases : Autoimmune Diseases, Brain Inflammation , Multiple Sclerosis
Pharmacological Actions : Immunomodulatory: Th17 downregulation, Immunosuppressive Agents
[+]

Arctigenin may have the potential to serve as a drug for protection of pigs against the infection of PCV2.May 31, 2016

Pubmed Data : Res Vet Sci. 2016 Jun ;106:159-64. Epub 2015 Oct 26. PMID: 27234554
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : Arctigenin, Burdock
Diseases : Animal Diseases: Porcine Circovirus Type 2 (PCV2)
Pharmacological Actions : Antiviral Agents
[+]

Arctigenin-containing burdock sprout extract prevents obesity in association with modulation of the gut microbiot.Dec 31, 2022

Pubmed Data : Biosci Microbiota Food Health. 2023 ;42(1):49-55. Epub 2022 Aug 25. PMID: 36660596
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Burdock, Genipin
Diseases : Obesity
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Anti-Obesity Agents
[+]

Arctii Fructus could be an effective therapeutic for treating or preventing obesity.Dec 06, 2016

Pubmed Data : Food Funct. 2016 Dec 7 ;7(12):5025-5033. PMID: 27882370
Article Published Date : Dec 06, 2016
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents, Burdock, obesity, Plant Extracts
[+]

Arctiin alleviates functional constipation by enhancing intestinal motility.Apr 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2023 May ;25(5):199. Epub 2023 Mar 20. PMID: 37090075
Article Published Date : Apr 30, 2023
Study Type : Animal Study
Additional Links
Substances : Burdock, Lignans
Diseases : Constipation
Pharmacological Actions : Gastrointestinal Agents
[+]

Arctiin mitigates neuronal injury by modulating the P2X7R/NLPR3 inflammasome signaling pathway.Aug 16, 2024

Pubmed Data : Inflammation. 2024 Aug 17. Epub 2024 Aug 17. PMID: 39154088
Article Published Date : Aug 16, 2024
Study Type : Animal Study
Additional Links
Substances : Burdock, Lignan
Diseases : Depression
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Arctiin prevents LPS-induced acute lung injury via inhibition of PI3K/AKT signaling pathway.Nov 30, 2018

Pubmed Data : Inflammation. 2018 Dec ;41(6):2129-2135. PMID: 30116933
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Sci. 2017 Nov ;135(3):97-104. Epub 2017 Aug 10. PMID: 29108833
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
Additional Keywords : Phytotherapy
[+]

Arctiin protects rat heart against ischemia/reperfusion injury.May 14, 2020

Pubmed Data : Eur J Pharmacol. 2020 May 15 ;875:173053. Epub 2020 Mar 2. PMID: 32135123
Article Published Date : May 14, 2020
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Myocardial Ischemia
Pharmacological Actions : Cardioprotective
[+]

Arctium lappa can prevent most of the hepatic tissue damage caused by acetaminophen overdose in rats.Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Curr Ther Res Clin Exp. 2015 Dec ;77:73-8. Epub 2015 May 27. PMID: 26543508
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Arctium lappa could be considered a potentially valuable medicinal food for dry age-related macular degeneration.Apr 08, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Apr 9 ;25(7). Epub 2020 Apr 9. PMID: 32283798
Article Published Date : Apr 08, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Burdock
Diseases : Macular Degeneration
Pharmacological Actions : Anti-Apoptotic
[+]

Arctium lappa extract suppresses inflammation and inhibits melanoma progression.Jul 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicines (Basel). 2019 Jul 29 ;6(3). Epub 2019 Jul 29. PMID: 31362372
Article Published Date : Jul 28, 2019
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Melanoma
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
[+]

Arctium lappa has ameliorative effects against cadmium genotoxicity.Dec 31, 2016

Pubmed Data : Pak J Biol Sci. 2017 ;20(6):314-319. PMID: 29023056
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Cadmium Poisoning
Pharmacological Actions : Genoprotective, Renoprotective
[+]

Arctium lappa L. polysaccharide can regulate lipid metabolism in type 2 diabetic rats.Jul 31, 2020

Pubmed Data : Carbohydr Res. 2020 Aug ;494:108055. Epub 2020 Jun 7. PMID: 32535406
Article Published Date : Jul 31, 2020
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Atherosclerosis, Diabetes Mellitus: Type 2
Pharmacological Actions : Hypolipidemic
Additional Keywords : Polysaccharides
[+]

Arctium lappa L. roots inhibit the intestinal inflammation of dietary obese rats through TLR4/NF-κB pathway.Oct 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2023 Nov ;9(11):e21562. Epub 2023 Nov 4. PMID: 38027866
Article Published Date : Oct 31, 2023
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Gastrointestinal Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Arctium lappa L. roots protect against cerebral ischemia through inhibiting apoptosis and AMPK/mTOR-mediated autophagy.Feb 20, 2021

Pubmed Data : Phytomedicine. 2021 Feb 21 ;85:153526. Epub 2021 Feb 21. PMID: 33691269
Article Published Date : Feb 20, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Burdock
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Apoptotic, Autophagy Up-regulation, Neuroprotective Agents
[+]

Arctium lappa leaves based on network pharmacology and experimental validation attenuate atherosclerosis.Aug 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2022 Sep ;153:113503. Epub 2022 Aug 16. PMID: 36076592
Article Published Date : Aug 31, 2022
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Atherosclerosis
Pharmacological Actions : Cardioprotective
[+]

Arctium lappa root extract containing L-arginine prevents TNF-α-induced early atherosclerosis in vitro and in vivo.Mar 20, 2020

Pubmed Data : Nutr Res. 2020 Mar 21 ;77:85-96. Epub 2020 Mar 21. PMID: 32388084
Article Published Date : Mar 20, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Burdock
Diseases : Atherosclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Arctium lappa root extract prevents lead-induced liver injury.Nov 23, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 Nov 24 ;8(12). Epub 2019 Nov 24. PMID: 31771282
Article Published Date : Nov 23, 2019
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Lead
[+]

Arctium minus crude extract presents antinociceptive effect in a mice acute gout attack model.Aug 10, 2017

Pubmed Data : Inflammopharmacology. 2017 Aug 11. Epub 2017 Aug 11. PMID: 28801728
Article Published Date : Aug 10, 2017
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Allodynia, Gout
Pharmacological Actions : Antinoceceptive
Additional Keywords : Plant Extracts
[+]

Burdock extracts may be beneficial in the treatment of diabetes.Feb 28, 2017

Pubmed Data : Avicenna J Phytomed. 2017 Mar-Apr;7(2):169-179. PMID: 28348972
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hepatoprotective, Hypolipidemic
Additional Keywords : Plant Extracts
[+]

Burdock has protective effects against ethanol induced testicular injuries.Jul 12, 2018

Pubmed Data : Andrologia. 2018 Jul 13:e13086. Epub 2018 Jul 13. PMID: 30003584
Article Published Date : Jul 12, 2018
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Alcohol Toxicity , Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants
[+]

Burdock root attenuates preneoplastic lesion development.Dec 04, 2019

Pubmed Data : Environ Toxicol. 2019 Dec 5. Epub 2019 Dec 5. PMID: 31804025
Article Published Date : Dec 04, 2019
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Liver Cancer, Nonalcoholic fatty liver disease (NAFLD), Preneoplastic Conditions
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antioxidants, Chemoprotective Agents, Hepatoprotective
Additional Keywords : Risk Reduction
[+]

Burdock root extract is a promising agent in the prevention of atherosclerosis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2016 ;16(1):6. Epub 2016 Jan 8. PMID: 26746431
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Atherosclerosis, High Fat Diet, Hyperlipidemia
Pharmacological Actions : Anticholesteremic Agents
[+]

Ethanolic extract of root from Arctium lappa L ameliorates obesity and hepatic steatosis.Sep 30, 2022

Pubmed Data : J Food Biochem. 2022 Oct 1:e14455. Epub 2022 Oct 1. PMID: 36183168
Article Published Date : Sep 30, 2022
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Liver Steatosis, Obesity
Pharmacological Actions : Hepatoprotective
Additional Keywords : Anti-Obesity Agents
[+]

Habitual consumption of A. lappa root in the evening may aid the maintenance of healthy intestinal microbiota.Feb 05, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Microorganisms. 2020 Feb 6 ;8(2). Epub 2020 Feb 6. PMID: 32041173
Article Published Date : Feb 05, 2020
Study Type : Animal Study
Additional Links
Substances : Burdock
Pharmacological Actions : Gastrointestinal Agents
[+]

In vivo and in vitro anti-inflammatory effects of water-soluble polysaccharide from Arctium lappa.Aug 14, 2019

Pubmed Data : Int J Biol Macromol. 2019 Aug 15 ;135:717-724. Epub 2019 May 23. PMID: 31129217
Article Published Date : Aug 14, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Burdock
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Polysaccharides
[+]

Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans.Aug 31, 2015

Pubmed Data : Phytochemistry. 2015 Sep ;117:340-350. Epub 2015 Jul 1. PMID: 26141518
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Burdock, Lignans
Diseases : Aging, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Pathology reduction and motor behavior improvement associated with ultrasound-mediated delivery of arctiin to the motor cortex.Aug 28, 2024

Pubmed Data : Ultrasonics. 2024 Aug 29 ;144:107449. Epub 2024 Aug 29. PMID: 39217855
Article Published Date : Aug 28, 2024
Study Type : Animal Study
Additional Links
Substances : Burdock, Lignan
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Neuroprotective Agents
[+]

Structural characterization of water-soluble polysaccharide from Arctium lappa and its effects on colitis mice.May 31, 2019

Pubmed Data : Carbohydr Polym. 2019 Jun 1 ;213:89-99. Epub 2019 Feb 27. PMID: 30879693
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Polysaccharides
[+]

Supplementation with burdock has a wide spectrum of bioactive effects, including health promotion, performance improvement, and fatigue reduction.Oct 06, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Vet Med Sci. 2017 Oct 7 ;79(10):1698-1706. Epub 2017 Sep 11. PMID: 28890521
Article Published Date : Oct 06, 2017
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Fatigue
Additional Keywords : Plant Extracts
[+]

Synergic effects of Trigonella foenum-graecum, Ribes rubrum, Lavandula angustifolia, and Arctium Lappa extracts mixture on learning and memory deficits.Dec 31, 2022

Pubmed Data : Iran J Basic Med Sci. 2023 ;26(12):1490-1497. PMID: 37970441
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Black Currant, Burdock, Fenugreek, Lavender
Diseases : Diabetes: Cognitive Dysfunction
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Natural Substance Synergy
[+]

The current study indicated that arctigenin exerted anti-ulcer activity.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Rep. 2016 Nov ;5(5):589-594. Epub 2016 Oct 4. PMID: 27882222
Article Published Date : Oct 31, 2016
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Gastric Ulcer
Pharmacological Actions : Anti-Inflammatory Agents, Gastroprotective, Interleukin-10 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

The effects of hypoglycemia and weight loss of total lignans from Fructus Arctii in KKAy mice and its mechanisms of the activity.Mar 31, 2018

Pubmed Data : Phytother Res. 2018 Apr ;32(4):631-642. Epub 2017 Dec 13. PMID: 29235180
Article Published Date : Mar 31, 2018
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Hypoglycemia
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic
[+]

The extract of Arctium lappa fruit improves cancer-induced cachexia.Oct 18, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Oct 19 ;12(10). Epub 2020 Oct 19. PMID: 33086629
Article Published Date : Oct 18, 2020
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Cachexia: Cancer
Pharmacological Actions : Anti-Cachexic Agents
[+]

The lipid-lowering effects of fenugreek gum, hawthorn pectin, and burdock inulin.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Nutr. 2023 ;10:1149094. Epub 2023 Mar 23. PMID: 37032784
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Burdock, Fenugreek, Hawthorn
Diseases : Hyperlipidemia
Pharmacological Actions : Gastrointestinal Agents, Hypolipidemic
[+]

The results showed that the A. lappa L. polysaccharides regulated lipid metabolism through the PKC/NF-κB pathway in diabetic rats.Aug 31, 2019

Pubmed Data : Int J Biol Macromol. 2019 Sep 1 ;136:115-122. Epub 2019 Jun 10. PMID: 31195041
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Diabetic Complications, Hyperlipidemia
Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic, NF-kappaB Inhibitor
Additional Keywords : Polysaccharides
[+]

Therapeutic effects of arctiin on Alzheimer's disease-like model.Aug 11, 2024

Pubmed Data : Curr Alzheimer Res. 2024 Aug 12. Epub 2024 Aug 12. PMID: 39136502
Article Published Date : Aug 11, 2024
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents, STAT3 Activation, Transforming growth factor beta (TGF-β) upregulation
[+]

Total lignans from Fructus arctii has a preventive and therapeutic effect on diabetic retinopathy.Jun 11, 2020

Pubmed Data : J Ethnopharmacol. 2020 Jun 12 ;255:112773. Epub 2020 Mar 18. PMID: 32199990
Article Published Date : Jun 11, 2020
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Diabetic Retinopathy
Pharmacological Actions : Anti-Apoptotic, Vascular Endothelial Growth Factor Inhibitors
[+]

Treatment with A. lappa resulted in body weight decrease and blood glucose suppression.Aug 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lab Anim Res. 2017 Sep ;33(3):251-255. Epub 2017 Sep 27. PMID: 29046701
Article Published Date : Aug 31, 2017
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Obesity
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Anti-Obesity Agents
[+]

A dried burdock root extract demonstrated anti-hyperglycemic properties.Aug 05, 2014

Pubmed Data : J Agric Food Chem. 2014 Aug 6 ;62(31):7738-45. Epub 2014 Jul 23. PMID: 24933284
Article Published Date : Aug 05, 2014
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Plant Extracts
[+]

A. lappa extracts are potential candidates for the treatment of inflammatory disorders that are complement-related.Oct 24, 2019

Pubmed Data : Chem Biodivers. 2019 Oct 25. Epub 2019 Oct 25. PMID: 31654480
Article Published Date : Oct 24, 2019
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

A. lappa may represent an interesting asset for researching and developing new therapies for inflammatory afflictions.Oct 04, 2022

Pubmed Data : Chem Biodivers. 2022 Oct 5. Epub 2022 Oct 5. PMID: 36198078
Article Published Date : Oct 04, 2022
Study Type : Review
Additional Links
Substances : Burdock
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

An ethyl acetate extract of burdock may be a promising neuroprotective agent for the prevention and treatment of neurodegenerative diseases.Jun 30, 2014

Pubmed Data : Environ Toxicol Pharmacol. 2014 Jul ;38(1):189-98. Epub 2014 Jun 7. PMID: 24956398
Article Published Date : Jun 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Oxidative Stress
Pharmacological Actions : Bax/Bcl2 ratio: Increase, Neuroprotective Agents, Superoxide Dismutase Up-regulation
Additional Keywords : Dose Response, Plant Extracts
[+]

An insight into the anticancer potentials of lignan arctiin.Jun 29, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2024 Jun 30 ;10(12):e32899. Epub 2024 Jun 13. PMID: 38988539
Article Published Date : Jun 29, 2024
Study Type : Review
Additional Links
Substances : Burdock, Lignans
Diseases : Cancers: All
Pharmacological Actions : Chemotherapeutic
[+]

Antidiabetic properties of the root extracts of dandelion and burdock.Apr 02, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Plants (Basel). 2024 Apr 3 ;13(7). Epub 2024 Apr 3. PMID: 38611548
Article Published Date : Apr 02, 2024
Study Type : In Vitro Study
Additional Links
Substances : Burdock, Dandelion
Diseases : Hyperglycemia
Pharmacological Actions : Alpha-amylase inhibitor, Hypoglycemic Agents
[+]

Arctigenin significantly inhibited the migration and invasion of MDA-MB-231 cells.Dec 31, 2016

Pubmed Data : Oncol Rep. 2017 Jan ;37(1):179-184. Epub 2016 Nov 23. PMID: 27878294
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Arctiin attenuates high glucose-induced human retinal capillary endothelial cell proliferation.Apr 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2020 May ;24(10):5695-5706. Epub 2020 Apr 16. PMID: 32297701
Article Published Date : Apr 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Diabetic Retinopathy
Pharmacological Actions : Antiproliferative , Cell cycle arrest
[+]

Arctiin has great value in treating various tumors sheltering constitutively activated STAT3.Feb 28, 2019

Pubmed Data : Phytomedicine. 2019 Mar 1 ;55:282-292. Epub 2018 Aug 11. PMID: 30668440
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Multiple Myeloma
Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Apoptotic, STAT3 Inhibitor
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

Arctiin inhibits cervical cancer cell migration and invasion.Feb 04, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceutics. 2022 Feb 5 ;14(2). Epub 2022 Feb 5. PMID: 35214097
Article Published Date : Feb 04, 2022
Study Type : In Vitro Study
Additional Links
Substances : Burdock, Lignans
Diseases : Cervical Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

Arctiin may serve as a novel therapeutic agent for the treatment of osteoporosis.Dec 31, 2019

Pubmed Data : Pharmacol Res. 2020 09 ;159:104944. Epub 2020 May 23. PMID: 32454224
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
[+]

Arctiin protected the UVB radiation‑mediated decrease in COL1A1 mRNA expression.Nov 30, 2017

Pubmed Data : Mol Med Rep. 2017 Dec ;16(6):9120-9124. Epub 2017 Oct 2. PMID: 28990056
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Ultraviolet Radiation Induced Damage
Pharmacological Actions : Photoprotective
[+]

Arctiin suppresses H9N2 avian influenza virus-mediated inflammation via activation of Nrf2/HO-1 signaling.Nov 25, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2021 Nov 26 ;21(1):289. Epub 2021 Nov 26. PMID: 34836523
Article Published Date : Nov 25, 2021
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Arctium lappa L. polysaccharides enhanced the therapeutic effects of nasal ectomesenchymal stem cells against liver fibrosis.Feb 29, 2024

Pubmed Data : Int J Biol Macromol. 2024 Mar ;261(Pt 1):129670. Epub 2024 Jan 26. PMID: 38280697
Article Published Date : Feb 29, 2024
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Liver Cirrhosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Polysaccharides
[+]

Arctium lappa L. root extract induces cell death via mitochondrial-mediated caspase-dependent apoptosis in Jurkat human leukemic T cells.Jan 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Feb ;110:918-929. Epub 2018 Dec 17. PMID: 30572196
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Acute T cell Leukemias
Pharmacological Actions : Apoptotic
Additional Keywords : Plant Extracts
[+]

Burdock and coltsfoot were shown to have anti-tubercular activity.Aug 07, 2014

Pubmed Data : J Ethnopharmacol. 2014 Aug 8 ;155(1):796-800. Epub 2014 Jun 20. PMID: 24955560
Article Published Date : Aug 07, 2014
Study Type : In Vitro Study
Additional Links
Substances : Burdock, Daisy
Diseases : Mycobacterium Tuberculosis
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Plant Extracts
[+]

Burdock and oleamide attenuated allergic reactions in vitro.May 10, 2016

Pubmed Data : J Agric Food Chem. 2016 May 11 ;64(18):3564-73. Epub 2016 Apr 26. PMID: 27087645
Article Published Date : May 10, 2016
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Allergies
Pharmacological Actions : Anti-Allergic Agents, Histamine down-regulation, Interleukin-4 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Burdock contains anti-leukemic activity.Feb 01, 2006

Pubmed Data : Planta Med. 2006 Feb;72(3):276-8. PMID: 16534737
Article Published Date : Feb 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Leukemia
[+]

Burdock extracts may be regarded as potential antioxidant agents and possess potent neuroprotective activity against H2O2-induced injury.Mar 31, 2015

Pubmed Data : Cell Mol Neurobiol. 2015 Apr ;35(3):335-44. Epub 2014 Oct 29. PMID: 25352420
Article Published Date : Mar 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Bax/Bcl2 ratio: Increase, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Burdock extracts might be useful as a therapeutic agent for treating various forms of allergic inflammation.Dec 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Mol Allergy. 2011 ;9(1):4. Epub 2011 Feb 8. PMID: 21303540
Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Allergies, Dermatitis: Contact, Inflammation
Pharmacological Actions : Anti-Allergic Agents, Anti-Inflammatory Agents, Interleukin-4 downregulation, Interleukin-5 downregulation, NF-kappaB Inhibitor
[+]

Burdock leaf extract significantly inhibited the formation of P. aeruginosa biofilm, as well as significantly decreasing virulence factors.Feb 28, 2017

Pubmed Data : J Appl Microbiol. 2017 Mar ;122(3):615-624. Epub 2017 Jan 18. PMID: 27860087
Article Published Date : Feb 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Pseudomonas aeruginosa
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Biofilm, Plant Extracts
[+]

Burdock leaf flavonoids could be used as a new type of functional factor for the development of antioxidant and anti-inflammatory foods.Jul 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Sci Nutr. 2022 Aug ;10(8):2718-2726. Epub 2022 May 12. PMID: 35959264
Article Published Date : Jul 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Burdock, Flavonoids
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Burdock leaf is safe and affordable option for the preservation of meats.Jul 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Food Prot. 2016 Aug ;79(8):1404-9. PMID: 27497128
Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Foodborne Pathogens: Prevention/Food Preservation
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Plant Extracts
[+]

Burdock root extract and its component chlorogenic acid have potential use in antibiofilm strategies against persistent K. pneumoniae infections.Mar 27, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Microbiol Biotechnol. 2017 Mar 28 ;27(3):542-551. PMID: 27974734
Article Published Date : Mar 27, 2017
Study Type : In Vitro Study
Additional Links
Substances : Burdock, Chlorogenic Acid
Diseases : Candida Albicans, Escherichia coli Infections, Klebsiella Infections
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Biofilm, Plant Extracts
[+]

Changes in chemical components and antitumor activity during the heating process of Fructus Arctii.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2019 Dec ;57(1):363-368. PMID: 31295042
Article Published Date : Nov 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Promyelocytic leukemia
Pharmacological Actions : Antiproliferative
[+]

Enhancement of the apoptotic effects of Arctii fructus extracts on cancer cells by the enzymatic bioconversion of lignans.Apr 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Sci Nutr. 2020 May ;8(5):2205-2213. Epub 2020 Apr 8. PMID: 32405377
Article Published Date : Apr 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Cancers: Drug Resistant, Colon Cancer, Lung Cancer
Pharmacological Actions : Apoptotic, Chemopreventive
[+]

Ethanolic extract of Arctium lappa leaves alleviates cerebral ischemia reperfusion-induced inflammatory injury.Jun 30, 2024

Pubmed Data : Phytomedicine. 2024 Jul ;129:155599. Epub 2024 Apr 7. PMID: 38669967
Article Published Date : Jun 30, 2024
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Evaluation of antimicrobial and cytotoxic effects of Echinacea and Arctium extracts and Zataria essential oil.Jun 14, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : AMB Express. 2022 Jun 15 ;12(1):75. Epub 2022 Jun 15. PMID: 35705727
Article Published Date : Jun 14, 2022
Study Type : In Vitro Study
Additional Links
Substances : Burdock, Echinacea, Zataria multiflora
Diseases : Escherichia coli Infections, Staphylococcus aureus infection, Steptococcus Mutans Infections, Streptococcus Infections
Pharmacological Actions : Antimicrobial
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation
[+]

Exploring the mechanism of Arctium Lappa leaves in the treatment of Alzheimer's disease.Jul 31, 2023

Pubmed Data : Adv Biol (Weinh). 2023 Aug ;7(8):e2300084. Epub 2023 Jun 29. PMID: 37382195
Article Published Date : Jul 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Alzheimer's Disease, Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
[+]

Extraction and antioxidant activities of polysaccharides from roots of Arctium lappa L.Nov 12, 2018

Pubmed Data : Int J Biol Macromol. 2018 Nov 13 ;123:531-538. Epub 2018 Nov 13. PMID: 30439439
Article Published Date : Nov 12, 2018
Study Type : In Vitro Study
Additional Links
Substances : Arctigenin, Burdock
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Polysaccharides
[+]

Fermented Arctium lappa fruit extract had an inhibitory effect on the IgE-mediated allergic response in RBL‑2H3 cells.Dec 27, 2015

Pubmed Data : Int J Mol Med. 2015 Dec 28. Epub 2015 Dec 28. PMID: 26707911
Article Published Date : Dec 27, 2015
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Allergies
Pharmacological Actions : Anti-Allergic Agents, Anti-Inflammatory Agents, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
[+]

Harnessing the power of Arctium lappa root: a review of its pharmacological properties and therapeutic applications.Aug 19, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nat Prod Bioprospect. 2024 Aug 20 ;14(1):49. Epub 2024 Aug 20. PMID: 39162715
Article Published Date : Aug 19, 2024
Study Type : Review
Additional Links
Substances : Burdock
Diseases : Acetaminophen (Tylenol) Toxicity , Alzheimer's Disease, Cadmium Poisoning , Chemically-Induced Liver Damage, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Aphrodisiac , Hepatoprotective, Hypolipidemic, Neuroprotective Agents
Problem Substances : Acetaminophen, Cadmium, Lead, Paracetamol
[+]

Induction of apoptosis, autophagy and ferroptosis by Thymus vulgaris and Arctium lappa extract.Oct 28, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Oct 29 ;25(21). Epub 2020 Oct 29. PMID: 33138135
Article Published Date : Oct 28, 2020
Study Type : In Vitro Study
Additional Links
Substances : Burdock, Thyme
Diseases : Leukemia, Multiple Myeloma
Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation
[+]

Intake of arctigenin could be an effective supplement for breast cancer patients.Dec 28, 2016

Pubmed Data : Int J Oncol. 2016 Dec 29. Epub 2016 Dec 29. PMID: 28035371
Article Published Date : Dec 28, 2016
Study Type : In Vitro Study
Additional Links
Substances : Arctigenin, Burdock
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
[+]

Lappaol F regulates the cell cycle by activating CDKN1C/p57 in human colorectal cancer cells.Nov 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2023 Dec ;61(1):337-344. PMID: 36708218
Article Published Date : Nov 30, 2023
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest
[+]

Mechanistic insights on burdock ( Arctium lappa L.) extract effects on diabetes mellitus.Jun 30, 2022

Pubmed Data : Food Sci Biotechnol. 2022 Jul ;31(8):999-1008. Epub 2022 Apr 25. PMID: 35873376
Article Published Date : Jun 30, 2022
Study Type : Review
Additional Links
Substances : Burdock
Diseases : Diabetes: Oxidative Stress, Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants
[+]

Medicinal herbs used in traditional management of breast cancer.Aug 13, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicines (Basel). 2020 Aug 14 ;7(8). Epub 2020 Aug 14. PMID: 32823812
Article Published Date : Aug 13, 2020
Study Type : Review
Additional Links
Substances : Black Cohosh, Burdock, Echinacea, Flaxseed, Garlic, Ginseng, Green Tea, Nigella sativa (aka Black Seed), Turmeric
Diseases : Breast Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Apoptotic
[+]

Natural lignans from Arctium lappa modulate P-glycoprotein efflux function in multidrug resistant cancer cells.Feb 14, 2015

Pubmed Data : Phytomedicine. 2015 Feb 15 ;22(2):301-7. Epub 2015 Jan 2. PMID: 25765837
Article Published Date : Feb 14, 2015
Study Type : In Vitro Study
Additional Links
Substances : Burdock, Lignans
Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Colon Cancer
Pharmacological Actions : Chemosensitizer, Multidrug Resistance Gene Modulators
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Neuroprotective effects of caffeoylquinic acid derivatives from the roots of Arctium lappa.Aug 31, 2020

Pubmed Data : Phytochemistry. 2020 Sep ;177:112432. Epub 2020 Jun 17. PMID: 32562918
Article Published Date : Aug 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Neuroprotective Agents
[+]

Onopordopicrin may be a potential therapeutic molecule to fight against oxidative stress in pathological specific muscle disorders.Mar 01, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Mar 2 ;26(5). Epub 2021 Mar 2. PMID: 33801315
Article Published Date : Mar 01, 2021
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Cachexia, Muscular Dystrophies, Oxidative Stress, Sarcopenia
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa.Apr 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharmacol Sin. 2018 May ;39(5):787-801. Epub 2018 Apr 26. PMID: 29698388
Article Published Date : Apr 30, 2018
Study Type : Review
Additional Links
Substances : Arctigenin, Burdock
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Renoprotective
[+]

Proapoptotic and antiangiogenic activities of Arctium lappa on breast cancer cell lines.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Scientifica (Cairo). 2020 ;2020:7286053. Epub 2020 May 17. PMID: 32509375
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Breast Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Apoptotic
[+]

The anti-proliferative and apoptotic effect of Arctium lappa root extract was similar to doxorubicin.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2017 03 1 ;18(3):795-802. Epub 2017 Mar 1. PMID: 28441789
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Natural Substances Versus Drugs, Superiority of Natural Substances versus Drugs
[+]

The burdock phytochemical inulin has prebiotic properties that could promote health.Feb 01, 2008

Pubmed Data : Anaerobe. 2008 Feb;14(1):29-34. Epub 2007 Nov 26. PMID: 18042411
Article Published Date : Feb 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Burdock, Inulin
Diseases : Dysbiosis
[+]

The combination of curcumin, EGCG and arctigenin synergistically enhanced the anti-proliferative effects in both prostate and breast cancer cells.Aug 04, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : RSC Adv. 2014 Aug 5 ;4(66):35242-35250. PMID: 25243063
Article Published Date : Aug 04, 2014
Study Type : In Vitro Study
Additional Links
Substances : Arctigenin, Burdock, Curcumin, EGCG (Epigallocatechin gallate), Green Tea
Diseases : Breast Cancer, Prostate Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive
Additional Keywords : Natural Substance Synergy
[+]

The experimental mix extract of Arctium lappa root powder and Aloe vera gel is able to inhibit very resistant microorganisms.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clujul Med. 2017 ;90(3):344-347. Epub 2017 Jul 15. PMID: 28781531
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Aloe Vera, Burdock
Diseases : Candida Albicans, Enterococcus Infections
Pharmacological Actions : Anti-Bacterial Agents, Antifungal Agents
[+]

The immunomodulatory potential of selected bioactive plant-based compounds in breast cancer.Dec 31, 2016

Pubmed Data : Anticancer Agents Med Chem. 2017 ;17(6):770-783. PMID: 27539316
Article Published Date : Dec 31, 2016
Study Type : Review
Additional Links
Substances : Apricot, Arctigenin, beta-Carotene, Burdock, Curcumin, EGCG (Epigallocatechin gallate), Garlic, Ginseng, Licorice, Quinic acid, Turmeric
Diseases : Breast Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Chemotherapeutic, Immunomodulatory
Additional Keywords : Plant Extracts
[+]

These results provide evidence of novel anti-inflammatory mechanisms of A. lappaDec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:6346734. Epub 2018 Jan 18. PMID: 29576797
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Inflammation, Peritonitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

This report provides the first evidence for the in vitro schistosomicidal and antiherpes activities of Arctium lappa.Sep 30, 2017

Pubmed Data : Biomed Pharmacother. 2017 Oct ;94:489-498. Epub 2017 Aug 3. PMID: 28780467
Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Herpes Simplex Virus Type 1, Parasitic Diseases
Pharmacological Actions : Antiparasitic Agents, Antiviral Agents
Additional Keywords : Plant Extracts
[+]

This reviews natural plants as breast cancer preventatives or use in treatments. Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi Pharm J. 2016 May ;24(3):233-40. Epub 2016 May 5. PMID: 27275107
Article Published Date : Apr 30, 2016
Study Type : Review
Additional Links
Substances : Ashwagandha, Black Cohosh, Burdock, Echinacea, Flavonoids, Flaxseed, Garlic, Ginseng, Polyphenols, Turmeric
Diseases : Breast Cancer
Pharmacological Actions : Antioxidants, Antiproliferative , Chemopreventive
[+]

This study demonstrates that Arctii Fructus inhibits the proliferation and metastatic properties of colorectal cancer cellsDec 31, 2016

Pubmed Data : Am J Chin Med. 2017 ;45(6):1309-1325. Epub 2017 Aug 22. PMID: 28830210
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Cancer Metastasis, Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : Plant Extracts
[+]

This study has identified a new mechanism of action of arctigenin against liver cancer growth.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:268. Epub 2018 Mar 27. PMID: 29636686
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Arctigenin, Burdock
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive
[+]

This study intends to provide reference for clinical use of traditional Chinese medicine to resist new coronavirus.Feb 29, 2020

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2020 Mar ;45(6):1225-1231. PMID: 32281329
Article Published Date : Feb 29, 2020
Study Type : In Vitro Study
Additional Links
Substances : Burdock, Ginger, Ginseng, Honeysuckle, Magnolia, Salvia miltiorrhiza
Diseases : Coronavirus Infection
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Cytokine Modulation, Cytokine Storm
[+]

Various herbs may have a therapeutic role in preventing and treating kidney and bladder stone formation. Jan 01, 1994

Pubmed Data : Int Urol Nephrol. 1994;26(5):507-11. PMID: 7860196
Article Published Date : Jan 01, 1994
Study Type : Review
Additional Links
Substances : Burdock, Dandelion , Horsetail, Lithospermum officinale, Silene saxifraga, Uva Ursi (aka Bearberry), Verbena officinalis
Diseases : Bladder Stones, Kidney Stones, Urolithiasis
[+]

Burdock has anti-allergic effects.Aug 14, 2008

Pubmed Data : Exp Biol Med (Maywood). 2008 Aug 14. PMID: 18703753
Article Published Date : Aug 14, 2008
Additional Links
Substances : Burdock
[+]

Topical application of Burdock (Arctium lappa) fruit extract improves the clinical signs of aging. Dec 01, 2008

Pubmed Data : J Cosmet Dermatol. 2008 Dec;7(4):281-9. PMID: 19146605
Article Published Date : Dec 01, 2008
Additional Links
Substances : Burdock
Diseases : Aging Skin

Copyright: volff / 123RF Stock Photo

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