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7 Diseases Researched for Cafestol

Name	AC	CK
Kidney Cancer	2	2
Bone Diseases	1	1
Diabetes Mellitus: Type 2: Prevention	1	1
Head and Neck Cancer	1	1
Mesothelioma	1	1
Osteoarthritis	1	1
Pain	1	1

15 Pharmacological Actions Researched for Cafestol

Name	AC	CK
Apoptotic	4	4
Antiproliferative	2	2
Anti-metastatic	1	1
Antinoceceptive	1	1
Bcl-2 protein down-regulation	1	1
Caspase-3 Activation	1	1
Cell cycle arrest	1	1
Chemosensitizer	1	1
Chemotherapeutic	1	1
Insulin-releasing	1	1
MicroRNA modulator	1	1
NF-kappaB Inhibitor	1	1
Nrf2 activation	1	1
Osteogenic	1	1
Osteoprotective	1	1

Research Articles 7
Cumulative Knowledge Score 11
Overall Research Rating GOOD

View the Evidence:
11 Abstracts with Cafestol Research

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Cafestol may contribute to the reduced risk of developing type-2 diabetes in coffee consumers.Jul 31, 2017

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Pubmed Data : J Nat Prod. 2017 Aug 1. Epub 2017 Aug 1. PMID: 28763212

Article Published Date : Jul 31, 2017

Study Type : Animal Study

Additional Links

Substances : Cafestol, Coffee

Diseases : Diabetes Mellitus: Type 2: Prevention

Pharmacological Actions : Hypoglycemic Agents, Insulin-releasing

Additional Keywords : Risk Reduction

[+]

"The coffee specific diterpene cafestol induces peripheral pain-killing properties mediated by endogenous opioid peptides."Feb 14, 2012

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Pubmed Data : Clin Exp Pharmacol Physiol. 2012 Feb 14. Epub 2012 Feb 14. PMID: 22332877

Article Published Date : Feb 14, 2012

Study Type : In Vitro Study

Additional Links

Substances : Cafestol

Diseases : Pain

Pharmacological Actions : Antinoceceptive

Additional Keywords : Food Opioids

[+]

Anti-proliferative and anti-migratory properties of coffee diterpenes kahweol acetate and cafestol in human renal cancer cells.Jan 11, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2021 Jan 12 ;11(1):675. Epub 2021 Jan 12. PMID: 33436830

Article Published Date : Jan 11, 2021

Study Type : In Vitro Study

Additional Links

Substances : Cafestol, Coffee

Diseases : Kidney Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

Additional Keywords : Tumor Microenvironment

[+]

Cafestol and kahweol are potential cancer treatments, or adjuvants as chemotherapeutic agents for malignant pleural mesothelioma.Jun 25, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Biomed Sci. 2012 Jun 26 ;19:60. Epub 2012 Jun 26. PMID: 22734486

Article Published Date : Jun 25, 2012

Study Type : In Vitro Study

Additional Links

Substances : Cafestol, Kahweol

Diseases : Mesothelioma

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Chemotherapeutic

[+]

Cafestol could have potential as a therapeutic agent for preventing cancers such as renal carcinoma.Apr 24, 2011

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Pubmed Data : Chem Biol Interact. 2011 Apr 25 ;190(2-3):102-8. Epub 2011 Feb 18. PMID: 21334318

Article Published Date : Apr 24, 2011

Study Type : In Vitro Study

Additional Links

Substances : Cafestol

Diseases : Kidney Cancer

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest

[+]

Cafestol may be a novel agent for bone diseases.Jun 30, 2015

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Pubmed Data : Biofactors. 2015 Jul-Aug;41(4):222-31. Epub 2015 Jul 7. PMID: 26154488

Article Published Date : Jun 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Cafestol, Kahweol

Diseases : Bone Diseases, Osteoarthritis

Pharmacological Actions : MicroRNA modulator, NF-kappaB Inhibitor, Nrf2 activation, Osteogenic, Osteoprotective

Additional Keywords : Dose Response

[+]

cafestol may be effectively used to enhance ABT-737 sensitivity in cancer therapy via downregulation of Mcl-1 expression and upregulation of Bim expression. Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Death Dis. 2014 ;5:e1514. Epub 2014 Nov 6. PMID: 25375379

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Cafestol

Diseases : Kidney Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy, Selective Cytotoxicity

[+]

Cafestol may contribute to the preventive effects on T2D in coffee drinkers and be of therapeutic interest.Oct 22, 2015

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Pubmed Data : J Nat Prod. 2015 Oct 23 ;78(10):2447-51. Epub 2015 Oct 14. PMID: 26465380

Article Published Date : Oct 22, 2015

Study Type : In Vitro Study

Additional Links

Substances : Cafestol, Caffeic Acid, Coffee

Diseases : Diabetes Mellitus: Type 2: Prevention

Pharmacological Actions : Insulin-releasing

Additional Keywords : Risk Reduction

[+]

Cafestol, a diterpene molecule found in coffee, induces leukemia cell death.Jul 31, 2017

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Pubmed Data : Biomed Pharmacother. 2017 Aug ;92:1045-1054. Epub 2017 Jun 10. PMID: 28618649

Article Published Date : Jul 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Cafestol

Diseases : Leukemia

Pharmacological Actions : Apoptotic

[+]

Secondary metabolites from spice and herbs as potential multitarget inhibitors of SARS-CoV-2 proteins.Oct 26, 2020

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Pubmed Data : J Biomol Struct Dyn. 2020 Oct 27:1-20. Epub 2020 Oct 27. PMID: 33107812

Article Published Date : Oct 26, 2020

Study Type : In Vitro Study

Additional Links

Substances : Cafestol, Culinary Herbs and Spices, Epicatechin, Hesperidin

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

[+]

Treatment of HNSCC cells with cafestol leads to a dose-dependent reduction of cell viability and to induction of apoptosis.May 31, 2015

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Pubmed Data : Strahlenther Onkol. 2015 Jun ;191(6):511-7. Epub 2015 Jan 10. PMID: 25575980

Article Published Date : May 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Cafestol, Coffee

Diseases : Head and Neck Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

Additional Keywords : Dose Response

Cafestol Related Articles

Coffee: Medicine for the Body and Soul

Written by Sayer Ji, Founder

Could coffee do more than just stimulate alertness and stress out the adrenals? What if there was more going on to this ritualistic beverage consumed by billions around the world than just caffeine addiction? What if it was medicine for both the body and soul?

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This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

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View the Evidence: 11 Abstracts with Cafestol Research

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Cafestol may contribute to the reduced risk of developing type-2 diabetes in coffee consumers.Jul 31, 2017

"The coffee specific diterpene cafestol induces peripheral pain-killing properties mediated by endogenous opioid peptides."Feb 14, 2012

Anti-proliferative and anti-migratory properties of coffee diterpenes kahweol acetate and cafestol in human renal cancer cells.Jan 11, 2021

Cafestol and kahweol are potential cancer treatments, or adjuvants as chemotherapeutic agents for malignant pleural mesothelioma.Jun 25, 2012

Cafestol could have potential as a therapeutic agent for preventing cancers such as renal carcinoma.Apr 24, 2011

Cafestol may be a novel agent for bone diseases.Jun 30, 2015

cafestol may be effectively used to enhance ABT-737 sensitivity in cancer therapy via downregulation of Mcl-1 expression and upregulation of Bim expression. Dec 31, 2013

Cafestol may contribute to the preventive effects on T2D in coffee drinkers and be of therapeutic interest.Oct 22, 2015

Cafestol, a diterpene molecule found in coffee, induces leukemia cell death.Jul 31, 2017

Secondary metabolites from spice and herbs as potential multitarget inhibitors of SARS-CoV-2 proteins.Oct 26, 2020

Treatment of HNSCC cells with cafestol leads to a dose-dependent reduction of cell viability and to induction of apoptosis.May 31, 2015

Cafestol Related Articles

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Cafestol

View the Evidence:
11 Abstracts with Cafestol Research