Cannabinoids: Synthetic

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40 Diseases Researched for Cannabinoids: Synthetic

Name	AC	CK
Multiple Sclerosis	5	24
Neuropathic Pain	2	12
Night Terror	1	10
Nightmare	1	10
Post-Traumatic Stress Disorders (PTSD)	1	10
Breast Cancer	5	7
Lymphoma	2	6
Cancers: All	4	5
Lung Cancer	3	4
Prostate Cancer	4	4
Carcinoma: Non-Small-Cell Lung	2	3
Epilepsy	2	3
Liver Cancer	3	3
Melanoma	2	3
Thyroid Cancer	2	3
Acute lymphoblastic leukemia (ALL)	1	2
Allodynia	1	2
Colorectal Cancer	2	2
Glioma	2	2
Hypothermia	1	2
Lipid Peroxidation	1	2
Periodontal Diseases	1	2
Periodontitis	1	2
Rhabdomyosarcoma	1	2
Rheumatoid Arthritis	1	2
Anorexia	1	1
Brain Inflammation	1	1
Cancer Metastasis	1	1
Cancer: Pain	1	1
Colon Cancer	1	1
Encephalomyelitis	1	1
Gastric Cancer	1	1
Inflammation	1	1
Kaposi Disease	1	1
Neurodegenerative Diseases	1	1
Obesity	1	1
Pancreatic Cancer	1	1
Parkinson's Disease	1	1
Schizophrenia	1	1
Skin Cancer	1	1

29 Pharmacological Actions Researched for Cannabinoids: Synthetic

Name	AC	CK
Apoptotic	16	27
Antiproliferative	12	18
Neuroprotective Agents	3	12
Anti-Anxiety Agents	1	10
Anti-metastatic	6	10
Anti-Inflammatory Agents	5	8
Antineoplastic Agents	5	8
Cannabinoid Receptor Antagonist/Inverse Agonist	4	6
P38 Mitogen-Activated Protein Kinase Modulator	1	5
Chemotherapeutic	3	4
Tumor Necrosis Factor (TNF) Alpha Inhibitor	2	4
Angiogenesis Inhibitors	2	3
Cell cycle arrest	2	3
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	3
Anti-Tumor	1	2
Anticonvulsants	1	2
Chemosensitizer	1	2
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor	1	2
Malondialdehyde Down-regulation	1	2
Osteoprotective	1	2
Topoisomerase II Inhibitor	2	2
Analgesics	1	1
Anticarcinogenic Agents	1	1
Bax/Bcl2 ratio: Increase	1	1
Bcl-2 protein down-regulation	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Paraptosis	1	1
Survivin Down-Regulation	1	1
Vascular Endothelial Growth Factor A Inhibitor	1	1

Research Articles 35
Cumulative Knowledge Score 56
Overall Research Rating GOOD

View the Evidence:
35 Abstracts with Cannabinoids: Synthetic Research

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View the Evidence: 35 Abstracts with Cannabinoids: Synthetic Research

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Nabilone as an adjunctive to gabapentin is an effective, well-tolerated combination for multiple sclerosis induced Neuropathic pain.Dec 31, 2014

Nabilone capsules provided significant relief for military personnel with trauma-related nightmares.Dec 31, 2014

This study may support the experimental and biological evidence for a neuroprotective effect by the endocannabinoid system in MS.Dec 23, 2014

The present data suggest that targeting CB(1)/CB(2) may have therapeutic potential for the treatment of mantle cell lymphoma.Oct 31, 2006

Cannabinoid receptor agonists HU210 and Delta(9)-tetrahydrocannabinol lowers the viability of translocation-positive rhabdomyosarcoma cells through the induction of apoptosis.Jun 30, 2009

Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice.May 31, 2012

Cannabinoids inhibit the growth of melanoma cells but not of normal melanocytes.Nov 30, 2006

Cannabinoids were effective in reducing the tumor load, prolonging the mean survival time as well as curing a significant proportion of mice in this study.Jul 14, 2002

HU-331 was more active on cancer growth and less toxic for the tumor-bearing host than doxorubicin.Jul 31, 2007

HU-444 represents a potential novel treatment for rheumatoid arthritis and other inflammatory diseases. Sep 30, 2015

JWH-015 treatment significantly reduced primary tumor burden and metastasis of luciferase-tagged murine mammary carcinoma 4T1 cells.Dec 31, 2015

JWH-015 treatment significantly reduced primary tumor burden and metastasis of luciferase-tagged murine mammary carcinoma 4T1 cells.Dec 31, 2015

Repeated administration of phytocannabinoid Delta-tetrahydrocannabinol or synthetic cannabinoids induces tolerance to hypothermia in mice.Nov 30, 2015

Short-term potentiation of the eCB system might modify the epileptogenic disease process in patients with a progressive course of epilepsy.May 31, 2015

Synthetic cannabinoids inhibited growth, migration and invasion of NSCLC cells in in vitro as well as in vivo in a mouse model.Dec 31, 2010

The discovery of IL-12-induced CB2 overexpression in thyroid cancer cells may offer a new target for anaplastic thyroid cancer treatmentJan 31, 2008

This study demonstrates anti-inflammatory, osteoprotective, and prohomeostatic effects of HU-308 in oral tissues of rats.May 31, 2016

WIN55212 and morphine reduced allodynia in a synergistic manner.Jun 08, 2016

A review of the many benefits of cannabinoids in health and disease.Dec 31, 2006

A review of the promising aspects of cannabinoid-based therapies for Parkinson's disease.Dec 31, 2014

Cannabigerol quinone (VCE-003) has high potential for use against MS and perhaps other neuroinflammatory diseases.Nov 30, 2012

Cannabinoid receptor agonists, including WIN, may be considered as novel therapeutics for the treatment of hepatocellular carcinoma.Nov 30, 2015

Cannabinoid receptor ligands induce decreased viability, growth suppression and cell death by apoptosis in MCL cells.Dec 18, 2005

Cannabinoids may be promising tools in combination therapy for breast and prostate cancers.Oct 31, 2016

Endocannabinoids may be a beneficial option for the treatment of prostate cancer that has become nonresponsive to common therapies.Mar 31, 2015

HU-331 inhibits the ATPase activity of topoisomerase IIα using a noncompetitive mechanism.Dec 14, 2014

Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent.Oct 31, 2011

Preclinical and clinical assessment of cannabinoids as anti-cancer agents.Dec 31, 2015

Some studies have thus far shown evidence to support the use of cannabinoids for some cancer, neuropathic, spasticity, acute pain, and chronic pain conditions.Sep 30, 2015

The cannabinoid quinone HU-331 is a highly specific inhibitor of topoisomerase II.Dec 31, 2006

The cannabinoid system could be a potential target for pharmacological treatment of Kaposi's sarcoma.Aug 14, 2009

The synthetic cannabinoid WIN 55,212-2 down regulated the Akt and Erk signalling pathways and led to induced apoptosis in glioma cells.Dec 31, 2004

This study demonstrates that AEA, THC, and HU 210 are all able to cause changes in integrated mitochondrial function, directly, in the absence of cannabinoid receptors.Dec 06, 2007

WIN 55,212-2 treatment inhibited the invasion of gastric cancer cells and down regulated the expression of MMP-2 and VEGF-A through the cannabinoid receptors.May 14, 2010

WIN induces a clear apoptotic effect which was accompanied by up-regulation of the death signaling factors and down regulation of the survival factors.Mar 31, 2009

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Cannabinoids: Synthetic

View the Evidence:
35 Abstracts with Cannabinoids: Synthetic Research