Capsaicin

Name	AC	CK
Gastric Cancer	3	22
Helicobacter Pylori Infection	2	22
Neuropathic Pain	2	20
Oxidative Stress	7	20
Obesity	3	13
Burning Mouth Syndrome	1	10
Complex Regional Pain Syndrome: Type I	1	10
Complex Regional Pain Syndrome: Type II	1	10
Dysphagia	1	10
Insulin Resistance	1	10
Peripheral Neuropathies	1	10
Vitiligo	1	10
Bladder Cancer	3	7
Cancers: Drug Resistant	2	6
Cancers: Multi-Drug Resistant	2	6
High Cholesterol	3	6
Hyperlipidemia	3	6
Cancers: All	5	5
Cholangiocarcinoma	1	5
Inflammation	4	5
Colon Cancer	2	4
Lung Cancer	3	4
Pancreatic Cancer	2	4
Benzo[a]pyrene-induced Toxicity	2	3
Cholesterol: Oxidation	2	3
Arthritis	1	2
Breast Cancer	2	2
Chemically-Induced Liver Damage	1	2
Epilepsy	1	2
Fat Malabsorption	1	2
Gastritis	1	2
Hepatic Steatosis	1	2
High Fat Diet	1	2
Hypercholesterolemia	1	2
Hypertension	1	2
Hypertension: Pulmonary	1	2
Hypoxia	1	2
Indigestion: Fats	1	2
Iron Poisoning	1	2
Liver Disease	1	2
Malabsorption Syndrome	1	2
Microvilli atrophy	1	2
Myocardial Infarction	1	2
Myocardial Ischemia	1	2
Pancreatitis	1	2
Steatorrhea	1	2
Stomach Cancer	2	2
Tumors	1	2
Acute Myeloid Leukemia	1	1
Adult T-cell leukemia/lymphoma (ATL)	1	1
Atherosclerosis	1	1
Chemotherapy-Induced Toxicity: Cisplatin	1	1
Cholera	1	1
Colorectal Cancer	1	1
Colorectal Cancer: Prevention	1	1
Copper Toxicity	1	1
Coronavirus Infection	1	1
Gallstones	1	1
Hyperglycemia	1	1
Lipid Peroxidation	1	1
Liver Cancer	1	1
Nasopharyngeal Cancer	1	1
Promyelocytic leukemia	1	1
Prostate Cancer	1	1
Squamous cell carcinoma	1	1
Streptococcus infections: Group A	1	1
Tongue Cancer	1	1

Name	AC	CK
Apoptotic	15	44
Chemopreventive	10	31
Anticarcinogenic Agents	6	28
Analgesics	2	20
Antioxidants	9	15
Chemosensitizer	6	11
Antioxidant Effects	1	10
Hepatoprotective	5	10
Insulin Sensitizers	1	10
Hypolipidemic	5	9
Anti-Inflammatory Agents	6	8
Antineoplastic Agents	3	7
Cardioprotective	3	6
NF-kappaB Inhibitor	5	6
Antiproliferative	5	5
Autophagy Inhibitors	1	5
Anti-Apoptotic	2	3
Cell cycle arrest	3	3
Chemotherapeutic	2	3
Enzyme Inhibitors	2	3
Anti-metastatic	2	2
Antiviral Agents	2	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Multidrug Resistance Gene Modulators	2	2
Neuroprotective Agents	1	2
Oncogene Suppressor	1	2
Tumor Suppressor Protein p53 Upregulation	2	2
Alpha-amylase inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Anti-Bacterial Agents	1	1
Antimicrobial	1	1
Bcl-2 protein down-regulation	1	1
Cyclooxygenase 2 Inhibitors	1	1
Hypoglycemic Agents	1	1
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	1
Immunomodulatory	1	1
Interleukin-8 downregulation	1	1
Leukotriene B4 downregulation	1	1
Leukotriene C4 Downregulation	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1
P-glycoprotein Inhibitors	1	1
Prostaglandin PGE2 downregulation	1	1
STAT3 Inhibitor	1	1
Wnt/β-catenin signaling pathway modulation	1	1

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Pubmed Data : Pain Med. 2022 Jul 7. Epub 2022 Jul 7. PMID: 35799365

Article Published Date : Jul 06, 2022

Study Type : Human Study

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Substances : Capsaicin

Diseases : Neuropathic Pain, Spinal Cord Injuries

Pharmacological Actions : Analgesics

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Capsaicin and its effect on exercise performance, fatigue and inflammation after exercise.Jan 05, 2022

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Pubmed Data : Nutrients. 2022 Jan 6 ;14(2). Epub 2022 Jan 6. PMID: 35057413

Problem Substances : Insulin

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Topical capsaicin might be an alternative for the short-term treatment of burning mouth syndrome.Dec 21, 2016

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Pubmed Data : Acta Odontol Scand. 2016 Dec 22:1-7. Epub 2016 Dec 22. PMID: 28007005

Article Published Date : Dec 21, 2016

Study Type : Human Study

Additional Links

Substances : Capsaicin

Diseases : Burning Mouth Syndrome

Pharmacological Actions : Analgesics

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Capsaicin induced apoptosis in human bladder cancer cells activates dendritic cells.Mar 31, 2015

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Pubmed Data : Nutrition. 2015 Apr ;31(4):578-81. Epub 2014 May 29. PMID: 25220876

Article Published Date : Mar 31, 2015

Study Type : Human In Vitro

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Substances : Capsaicin

Diseases : Bladder Cancer

Pharmacological Actions : Apoptotic

Additional Keywords : Phytotherapy, Plant Extracts

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Capsaicin inhibits 5-FU-induced autophagy and rendering Cholangiocarcinoma cells more susceptible to 5-FU-induced apoptosis.Dec 31, 2014

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Pubmed Data : PLoS One. 2015 ;10(5):e0121538. Epub 2015 May 1. PMID: 25933112

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Capsaicin affects macrophage anti-inflammatory activity via the MAPK and NF-κB signaling pathways.Jul 07, 2021

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Pubmed Data : Int J Vitam Nutr Res. 2021 Jul 8. Epub 2021 Jul 8. PMID: 34235954

Article Published Date : Jul 07, 2021

Study Type : Animal Study

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Substances : Capsaicin

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Capsaicin alleviates vascular endothelial dysfunction and cardiomyopathy.Dec 31, 2021

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Pubmed Data : Phytother Res. 2008 Apr;22(4):529-33. PMID: 18338764

Article Published Date : Apr 01, 2008

Study Type : Animal Study

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Substances : Capsaicin

Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer, Oxidative Stress

Pharmacological Actions : Antioxidants

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Capsaicin ameliorates renal fibrosis by inhibiting TGF-β1-Smad2/3 signaling.May 31, 2022

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Pubmed Data : Phytomedicine. 2022 Jun ;100:154067. Epub 2022 Mar 21. PMID: 35349832

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Pubmed Data : Biomed Pharmacother. 2021 Sep ;141:111950. Epub 2021 Jul 23. PMID: 34328106

Article Published Date : Aug 31, 2021

Study Type : Animal Study

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Substances : Capsaicin

Diseases : Psoriasis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-22 Downregulation, Interleukin-23 Downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Capsaicin improves cognitive function in rats with chronic cerebral hypoperfusion.Dec 31, 2021

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Pubmed Data : Reprod Fertil Dev. 2022 Feb ;34(3):350-361. PMID: 35101163

Article Published Date : Jan 31, 2022

Study Type : Animal Study

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Substances : Capsaicin

Diseases : Oxidative Stress, Radiotherapy

Pharmacological Actions : Anti-Apoptotic, Radioprotective

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Capsaicin protects against lipopolysaccharide-induced acute lung injury.Dec 31, 2020

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Pubmed Data : Carcinogenesis. 2011 Nov ;32(11):1689-96. Epub 2011 Aug 22. PMID: 21859833

Article Published Date : Oct 31, 2011

Study Type : Animal Study

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Substances : Capsaicin

Diseases : Pancreatic Cancer, Pancreatitis

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

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Combination of two or three components showed striking synergetic effect with gemcitabine in vitro.Jan 11, 2017

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Pubmed Data : Cancer Lett. 2017 Jan 12. Epub 2017 Jan 12. PMID: 28089829

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Pubmed Data : Arch Physiol Biochem. 2015 Dec 26:1-29. Epub 2015 Dec 26. PMID: 26706937

A synergistic induction of apoptosis and inhibition of cell proliferation was observed in human colorectal cancer cells treated with the combination of capsaicin and DIM.May 05, 2015

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Pubmed Data : J Agric Food Chem. 2015 May 6 ;63(17):4297-304. Epub 2015 Apr 22. PMID: 25876645

Article Published Date : May 05, 2015

Study Type : In Vitro Study

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Substances : Capsaicin

Diseases : Colorectal Cancer, Colorectal Cancer: Prevention

Pharmacological Actions : Antiproliferative , Apoptotic, Chemopreventive, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Dietary Concentrations, Natural Substance Synergy

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Allicin and capsaicin ameliorated hypercholesterolemia.Nov 17, 2022

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Capsaicin and piperine can overcome multidrug resistance in cancer cells to doxorubicin.Mar 01, 2018

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Pubmed Data : Food Funct. 2020 Oct 21 ;11(10):9020-9034. PMID: 33016967

Article Published Date : Oct 20, 2020

Study Type : In Vitro Study

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Substances : Capsaicin, Eugenol

Diseases : Gastric Cancer

Pharmacological Actions : Anti-metastatic

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Hepatoprotection of capsaicin in alcoholic and non-alcoholic fatty liver diseases.Aug 15, 2021

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Pubmed Data : Arch Physiol Biochem. 2021 Aug 16:1-11. Epub 2021 Aug 16. PMID: 34396890

Article Published Date : Aug 15, 2021

Study Type : Review

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Substances : Capsaicin

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

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Herbal anti-inflammatory agents for skin disease.Jan 01, 2000

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Pubmed Data : Adv Nutr. 2021 12 1 ;12(6):2232-2243. PMID: 34171094

Article Published Date : Dec 31, 2020

Study Type : Review

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Substances : Capsaicin

Diseases : Obesity

Additional Keywords : Anti-Obesity Agents

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Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis.Apr 06, 2021

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Pubmed Data : Pharmacol Res. 2021 Apr 7:105599. Epub 2021 Apr 7. PMID: 33838291

Article Published Date : Apr 06, 2021

Study Type : Review

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Substances : Allicin, Apigenin, Blueberry, Capsaicin, Celastrol, EGCG (Epigallocatechin gallate), Ellagic Acid, Folic Acid , Ginsenosides, Kaempferol, Lycopene, Paeoniflorin, Paeonol, Quercetin, Resveratrol

Diseases : Atherosclerosis

Pharmacological Actions : Anti-Apoptotic, Antioxidants

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The aflatoxin inhibitors capsaicin and piperine from Capsicum chinense and Piper nigrum fruits modulate the antioxidant system in Aspergillus parasiticus.Dec 31, 2021

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Pubmed Data : J Environ Sci Health B. 2022 ;57(5):358-368. Epub 2022 Apr 8. PMID: 35392762

Article Published Date : Dec 31, 2021

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Pubmed Data : Front Plant Sci. 2015 ;6:655. Epub 2015 Aug 25. PMID: 26379683

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Substances : Andrographolide, Capsaicin, Curcumin, EGCG (Epigallocatechin gallate), Genistein, Quercetin, Resveratrol

Pharmacological Actions : Immunomodulatory

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The results conclusively prove the efficacy of the antioxidant property of capsaicin and its role in modulating the redox status of red blood cells.Oct 31, 2015

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Pubmed Data : Adv Pharm Bull. 2015 Nov ;5(4):583-6. Epub 2015 Nov 30. PMID: 26819932

Article Published Date : Oct 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Capsaicin, Chili pepper

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants

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These results reveal a novel mechanism by which capsaicin sensitizes oral cancer cells to anticancer drugs.Dec 31, 2020

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Pubmed Data : Front Pharmacol. 2021 ;12:676813. Epub 2021 Aug 27. PMID: 34512323

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Capsaicin

Diseases : Oral Cancer, Squamous cell carcinoma

Pharmacological Actions : Apoptotic, Chemosensitizer

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View the Evidence: 128 Abstracts with Capsaicin Research

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Lipid-lowering efficacy of the capsaicin in patients with metabolic syndrome.Dec 31, 2021

This meta-analysis implies moderation in capsaicin consumption in order to derive its protective benefits.Aug 31, 2014

A capsaicin 8% patch provided non-inferior pain relief to an optimized dose of pregabalin in peripheral neuropathic pain.Nov 18, 2015

Acute supplementation with capsaicin enhances upper-limb performance in male Jiu-Jitsu athletes.Aug 08, 2022

Aural stimulation with capsaicin represents a novel treatment for dysphagia.Oct 31, 2015

Capsaicin 8% for peripheral neuropathic pain treatment.Dec 31, 2021

Capsaicin 8% patch for spinal cord injury focal neuropathic pain.Jul 06, 2022

Capsaicin and its effect on exercise performance, fatigue and inflammation after exercise.Jan 05, 2022

Capsaicin may improve swallowing impairment in patients with amyotrophic lateral sclerosis.Mar 31, 2022

Capsaicin treatment in neuropathic pain: axon reflex vasodilatation after four weeks correlates with pain reduction.Jul 19, 2022

Curcumin and capsaicin might represent an alternative approach to protect against vitiligo progression.Jan 19, 2010

Intermittent application of large-dose topical capsaicin may provide significant pain relief, decrease chronic analgesic dependence, and decrease aggregate health care expenditures.Mar 01, 1998

This study found that that taking green tea, capsaicin and ginger co-supplements for 8 weeks among overweight women had beneficial effects on weight, BMI, markers of insulin metabolism and plasma glutathione levels.Jan 01, 2017

Topical capsaicin might be an alternative for the short-term treatment of burning mouth syndrome.Dec 21, 2016

Capsaicin induced apoptosis in human bladder cancer cells activates dendritic cells.Mar 31, 2015

Capsaicin inhibits 5-FU-induced autophagy and rendering Cholangiocarcinoma cells more susceptible to 5-FU-induced apoptosis.Dec 31, 2014

Capsaicin alleviates cisplatin-induced muscle loss and atrophy in vitro and in vivo.Nov 17, 2022

Capsaicin exerts therapeutic effects by targeting tNOX-SIRT1 axis and augmenting ROS-dependent autophagy in melanoma cancer cells.Dec 31, 2020

"Antitumor activity of capsaicin on human colon cancer cells in vitro and colo 205 tumor xenografts in vivo.Dec 21, 2010

"Antitumor activity of capsaicin on human colon cancer cells in vitro and colo 205 tumor xenografts in vivo."Dec 21, 2010

"Apoptosis inhibition of capsaicin on myocardial ischemia-reperfusion injury in rats"Feb 28, 2011

Administration of Lycium barbarum polysaccharides and capsaicin attenuate dextran sulfate sodium-induced ulcerative colitis symptoms.Feb 21, 2022

Capsaicin affects macrophage anti-inflammatory activity via the MAPK and NF-κB signaling pathways.Jul 07, 2021

Capsaicin alleviates vascular endothelial dysfunction and cardiomyopathy.Dec 31, 2021

Capsaicin ameliorate the nephrotoxicity induced by methotrexate.Oct 31, 2021

Capsaicin ameliorates high-fat diet-induced atherosclerosis.Oct 16, 2022

Capsaicin ameliorates oxidative stress mediated damage produced during benzo(a)pyrene-induced lung cancer.Apr 01, 2008

Capsaicin ameliorates renal fibrosis by inhibiting TGF-β1-Smad2/3 signaling.May 31, 2022

Capsaicin and curcumin lower levels of an arthritis-associated glycoprotein in the sera of rats.Apr 01, 1997

Capsaicin attenuates arterial calcification.Dec 31, 2021

Capsaicin attenuates imiquimod-induced epidermal hyperplasia and cutaneous inflammation in a murine model of psoriasis.Aug 31, 2021

Capsaicin improves cognitive function in rats with chronic cerebral hypoperfusion.Dec 31, 2021

Capsaicin inhibits inflammation and gastric damage during H pylori infection by targeting NF-kB-miRNA axis.May 31, 2022

Capsaicin pretreatment attenuates chronic hypoxic pulmonary hypertension.Feb 01, 1995

Capsaicin prevents contrast-associated acute kidney injury.Dec 31, 2021

Capsaicin prevents radiotherapy-induced premature ovarian failure in rats.Jan 31, 2022

Capsaicin protects against lipopolysaccharide-induced acute lung injury.Dec 31, 2020

Capsaicin regulates dyslipidemia by altering the composition of bile acids in germ-free mice.Sep 28, 2022

Capsaicin regulates lipid metabolism through modulation of bile acid/gut microbiota metabolism in high-fat-fed SD rats.Dec 31, 2021

Capsaicin significantly reduced the severity of chronic pancreatitis in mice. Oct 31, 2011

Combination of two or three components showed striking synergetic effect with gemcitabine in vitro.Jan 11, 2017

Curcumin and capsaicin exert anti-tumor promotional effects through suppression of the tumor promoter-induced activation.Jan 01, 2000

Curcumin and capsaicin have hypolipidemic and antioxidant effects in high-fat-fed rats. Jun 01, 2007

Curcumin and capsaicin individually are protective to LDL oxidation both in vivo and in vitro, to iron-induced hepatotoxicity and to carrageenan-induced inflammation.Aug 26, 2009

Curcumin and capsaicin treatments attenuated hepatic fat accumulation and increased leptin levels related to inflammation. Dec 25, 2015

Curcumin, capsaicin and garlic attenuate adverse blood changes associated with a cholesterol-enriched diet.Jan 01, 2005

Curcumin, capsaicin and garlic have a beneficial influence on erythrocyte integrity in high-fat fed rats.Jul 01, 2006

Curcumin, capsaicin and garlic inhibit adverse blood and liver changes associated wtih a high-fat diet in rats.Sep 01, 2004

Curcumin, capsaicin and garlic reduce adverse changes in red blood cells associated with hypercholesterolemia. Jul 01, 2002

Curcumin, capsaicin and piperine have anti-inflammatory effects on H. pylori-induced gastritis in gerbils and may have potential chemoprevention of H. pylori-associated gastric carcinogenesis.Jul 02, 2015

Curcumin, capsaicin, and garlic have a beneficial effect in the red blood cells and liver of cholesterol fed rats.Oct 01, 2007

Dietary capsaicin reduces chemically induced urinary bladder carcinogenesis. Nov 04, 2022

Dietary curcumin and capsaicin have hypolipidemic and antioxidant effects. Dec 07, 2001

Dietary ginger and other spice compounds enhance fat digestion and absorption in high-fat fed situation through enhanced secretion of bile salts and a stimulation of the activity pancreatic lipase.Sep 13, 2011

Dietary spices have a beneficial effect on intestinal villi by increasing the absorptive surface of the small intestine, providing for an increased bioavailability of micronutrients.Feb 24, 2010

Electromagnetic radiation (Wi-Fi) and epilepsy induce calcium entry and apoptosis.Aug 31, 2014

Hesperidin and capsaicin prevent hepatic steatosis and other metabolic syndrome-related alterations in western diet-fed rats.Oct 09, 2018

Mucin secretory action of capsaicin prevents high fat diet-induced gut barrier dysfunction.Dec 31, 2021

Therapeutic effects of thymoquinone or capsaicin on acrylamide-induced reproductive toxicity.Jul 06, 2021

An in-silico evaluation of dietary components for structural inhibition of SARS-Cov-2 main protease.Aug 17, 2020

"Capsaicin induces apoptosis of cisplatin-resistant stomach cancer cells by causing degradation of cisplatin-inducible Aurora-A protein."Dec 31, 2010

"Capsaicin induces cycle arrest by inhibiting cyclin-dependent-kinase in bladder carcinoma cells."Jun 30, 2012

"Capsaicin-induced apoptosis of FaDu human pharyngeal squamous carcinoma cells."Jun 30, 2012

A review of in vitro and vivo antihepatocarcinogenic effects of natural compounds. Jul 31, 2011

A review of targeting oncogenic transcription factors by polyphenols.Jan 03, 2018

A review of the role of phytochemicals in cancer prevention.Oct 08, 2019

A synergistic induction of apoptosis and inhibition of cell proliferation was observed in human colorectal cancer cells treated with the combination of capsaicin and DIM.May 05, 2015

Allicin and capsaicin ameliorated hypercholesterolemia.Nov 17, 2022

Anti-cancer activity of sustained release capsaicin formulations.Mar 25, 2022

Beneficial effects of capsaicin in disorders of the central nervous system. Apr 11, 2022

Beneficial effects of dietary capsaicin in gastrointestinal health and disease.Aug 14, 2022

Capsaicin ameliorates diabetic retinopathy by inhibiting poldip2-induced oxidative stress.Jan 09, 2022

Capsaicin

View the Evidence:
128 Abstracts with Capsaicin Research