Carnosic Acid

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69 Diseases Researched for Carnosic Acid
NameACCKFocus
Neuropathic Pain48Locked
Oxidative Stress68Locked
Neurodegenerative Diseases57Locked
High Fat Diet36Locked
Inflammation46Locked
Nonalcoholic fatty liver disease (NAFLD)36Locked
Acrylamide-induced toxicity35Locked
Brain Inflammation 35Locked
Osteoarthritis15Locked
Alzheimer's Disease34Locked
Brain: Oxidative Stress24Locked
Breast Cancer24Locked
Colon Cancer34Locked
Liver Cancer34Locked
Lung Cancer34Locked
Parkinson's Disease44Locked
Advanced Glycation End products (AGE)23Locked
Cancers: All33Locked
Lipopolysaccharide-Induced Toxicity23Locked
Pesticide Toxicity 23Locked
Acetaminophen (Tylenol) Toxicity 12Locked
Acute Myeloid Leukemia22Locked
Aging: Brain 12Locked
Amyotrophic lateral sclerosis (ALS)12Locked
Arthritis12Locked
Bone Diseases12Locked
Brain Injury: Traumatic12Locked
Breast Cancer: Triple Negative 22Locked
Cardiovascular Diseases12Locked
Cervical Cancer12Locked
Chemically-Induced Liver Damage12Locked
Colon Cancer: Prevention12Locked
Diabetic Complications12Locked
Diabetic Nephropathy12Locked
Eye Damage12Locked
Fibrosis22Locked
Hypertension12Locked
Kidney Damage: Chemically-Induced12Locked
Learning disorders12Locked
Lung Injury: Acute12Locked
Melanoma22Locked
Memory Disorders12Locked
Obesity12Locked
Prostate Cancer22Locked
Pulmonary Fibrosis: Bleomycin-Induced12Locked
Rheumatoid Arthritis12Locked
Sciatic Nerve Crush Injury12Locked
Subarachnoid hemorrhage12Locked
Triglycerides: Elevated12Locked
Atopic Dermatitis11Locked
Carcinoma: Non-Small-Cell Lung11Locked
Chronic Myeloid Leukemia11Locked
Colitis11Locked
Colorectal Cancer11Locked
Common Cold11Locked
Depression11Locked
Diabetes Mellitus: Type 211Locked
Glioblastoma11Locked
Glioma11Locked
HIV Infections11Locked
Huntington Disease11Locked
Hydrogen Peroxide Induced Toxicity11Locked
Hyperglycemia11Locked
Hypoxia11Locked
Influenza11Locked
Ischemia: Myocardial11Locked
Kidney Cancer11Locked
Myocardial Ischemia11Locked
Staphylococcus aureus infection11Locked
62 Pharmacological Actions Researched for Carnosic Acid
NameACCKFocus
Antioxidants2745Locked
Anti-Inflammatory Agents2135Locked
Neuroprotective Agents1627Locked
Antiproliferative 1720Locked
Apoptotic1520Locked
Anti-Apoptotic713Locked
Interleukin-6 Downregulation612Locked
NF-kappaB Inhibitor712Locked
Nrf2 activation711Locked
Interleukin-1 beta downregulation59Locked
Cell cycle arrest78Locked
Hepatoprotective48Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor58Locked
Heme oxygenase-1 up-regulation27Locked
Osteoprotective 27Locked
Chemotherapeutic56Locked
Malondialdehyde Down-regulation36Locked
Antineoplastic Agents34Locked
Antinoceceptive 24Locked
Bcl-2 protein down-regulation34Locked
MicroRNA modulator34Locked
Analgesics23Locked
Anti-Fibrotic23Locked
Anti-Glycation Agents23Locked
Chemopreventive23Locked
SIRT1 Activator23Locked
Superoxide Dismutase Up-regulation23Locked
Anti-Angiogenic12Locked
Anti-Bacterial Agents22Locked
Anticarcinogenic Agents12Locked
Bcl-xL down-regulation12Locked
Cardioprotective22Locked
Chemoprotective Agents12Locked
Hypolipidemic12Locked
Interleukin-17 downregulation12Locked
Interleukin-8 downregulation12Locked
Matrix metalloproteinase-3 (MMP-3) inhibitor12Locked
Renoprotective12Locked
Tumor Suppressor Protein p53 Upregulation22Locked
Alpha-amylase inhibitor11Locked
Alpha-glucosidase inhibitor 11Locked
Anti-Infective Agents11Locked
Anti-metastatic11Locked
Antimicrobial11Locked
Antiviral Agents11Locked
Autophagy Inhibitors11Locked
Autophagy Up-regulation11Locked
Caspase-3 Activation11Locked
Caspase-9 Activation11Locked
Chemosensitizer11Locked
Cyclooxygenase 2 Inhibitors11Locked
Cytotoxic11Locked
HIV Protease Inhibitors11Locked
Heme oxygenase-1 inducer11Locked
Hypoglycemic Agents11Locked
Immunomodulatory11Locked
Multidrug Resistance Gene Modulators11Locked
NF-E2-Related Factor-2 (Nrf2) Modulator11Locked
Neuritogenic11Locked
Quorum Sensing Inhibition11Locked
Radioprotective11Locked
STAT3 Inhibitor11Locked

View the Evidence:
104 Abstracts with Carnosic Acid Research

[+]

Carnosic acid attenuates cartilage degeneration in human articular chondrocytes.Jul 04, 2018

Pubmed Data : Eur J Pharmacol. 2018 Jul 5 ;830:1-8. Epub 2018 Apr 17. PMID: 29678719
Article Published Date : Jul 04, 2018
Study Type : Human In Vitro
Additional Links
Substances : Carnosic Acid
Diseases : Osteoarthritis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Osteoprotective
[+]

Multi-target effects of ß-caryophyllene and carnosic acid at the crossroads of mitochondrial dysfunction and neurodegeneration.Jun 17, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2022 Jun 18 ;11(6). Epub 2022 Jun 18. PMID: 35740096
Article Published Date : Jun 17, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Beta-Caryophyllene, Carnosic Acid
Diseases : Alzheimer's Disease, Brain: Oxidative Stress, Brain Inflammation , Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Alteration of gut microbiota in high-fat diet-induced obese mice using carnosic acid from rosemary.Jun 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Sci Nutr. 2022 Jul ;10(7):2325-2332. Epub 2022 May 24. PMID: 35844908
Article Published Date : Jun 30, 2022
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : High Fat Diet, Obesity
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Anti-Obesity Agents
[+]

Both rosemary extracts administrated alone or in combination alleviated synergistically lung fibrosis.Oct 15, 2020

Pubmed Data : Nutr Cancer. 2020 Oct 16:1-12. Epub 2020 Oct 16. PMID: 33059466
Article Published Date : Oct 15, 2020
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid, Rosemary
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
Additional Keywords : Natural Substance Synergy
[+]

Carnosic acid alleviates chlorpyrifos-induced oxidative stress and inflammation in mice cerebral and ocular tissues.Jan 21, 2020

Pubmed Data : Environ Sci Pollut Res Int. 2020 Jan 22. Epub 2020 Jan 22. PMID: 31965510
Article Published Date : Jan 21, 2020
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Brain: Oxidative Stress, Brain Inflammation , Pesticide Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
Problem Substances : Chlorpyrifos
[+]

Carnosic acid alleviates levodopa-induced dyskinesia and cell death.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:703894. Epub 2021 Aug 9. PMID: 34434108
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Carnosic acid ameliorates indomethacin-induced gastric ulceration.Mar 08, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicines. 2023 Mar 9 ;11(3). Epub 2023 Mar 9. PMID: 36979808
Article Published Date : Mar 08, 2023
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Gastric Ulcer
Pharmacological Actions : Anti-Inflammatory Agents, Anti-Ulcer Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation
Problem Substances : Indomethacin
[+]

Carnosic acid and fisetin combination therapy enhances inhibition of lung cancer through apoptosis induction.Apr 19, 2017

Pubmed Data : Int J Oncol. 2017 Apr 20. Epub 2017 Apr 20. PMID: 28440400
Article Published Date : Apr 19, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid, Fisetin
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Natural Substance Synergy
[+]

Carnosic acid and rosemary extract reversed the lipid accumulation induced by bisphenol A.Aug 31, 2023

Pubmed Data : Food Chem Toxicol. 2023 Sep ;179:113996. Epub 2023 Aug 19. PMID: 37598852
Article Published Date : Aug 31, 2023
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid, Rosemary
Diseases : Bisphenol Toxicity
Pharmacological Actions : Hypolipidemic, SIRT1 Activator
Problem Substances : Bisphenol A
[+]

Carnosic acid appears to alleviate adipocity-related acceleration of colon tumor formation.Nov 30, 2014

Pubmed Data : Mol Nutr Food Res. 2014 Dec ;58(12):2274-85. Epub 2014 Oct 9. PMID: 25204550
Article Published Date : Nov 30, 2014
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemopreventive, Interleukin-6 Downregulation
Additional Keywords : Plant Extracts
[+]

Carnosic acid attenuates acrylamide-induced retinal toxicity in zebrafish embryos.Jan 09, 2018

Pubmed Data : Exp Eye Res. 2018 10 ;175:103-114. Epub 2018 Jun 18. PMID: 29928899
Article Published Date : Jan 09, 2018
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Acrylamide-induced toxicity, Eye Damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Superoxide Dismutase Up-regulation
Problem Substances : Acrylamide
[+]

Carnosic acid attenuates arsenic-induced hepatotoxicity.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:1421438. Epub 2018 May 2. PMID: 29854073
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Chemically-Induced Liver Damage, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective
Problem Substances : Arsenic
[+]

Carnosic acid attenuates AβOs-induced apoptosis and synaptic impairment.Dec 31, 2022

Pubmed Data : Mol Neurobiol. 2023 Jan ;60(1):133-144. Epub 2022 Oct 13. PMID: 36224322
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Carnosic acid attenuates cadmium induced nephrotoxicity.Nov 17, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Nov 18 ;24(22). Epub 2019 Nov 18. PMID: 31752142
Article Published Date : Nov 17, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Kidney Damage: Chemically-Induced
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
Problem Substances : Cadmium
[+]

Carnosic acid attenuates collagen-induced arthritis.Mar 22, 2017

Pubmed Data : Free Radic Biol Med. 2017 Mar 23 ;108:418-432. Epub 2017 Mar 23. PMID: 28343998
Article Published Date : Mar 22, 2017
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor
[+]

Carnosic acid attenuates doxorubicin-induced cardiotoxicity.Jul 31, 2022

Pubmed Data : Food Chem Toxicol. 2022 Aug ;166:113205. Epub 2022 Jun 5. PMID: 35675861
Article Published Date : Jul 31, 2022
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents
[+]

Carnosic acid attenuates RANKL-induced oxidative stress and osteoclastogenesis.Sep 30, 2017

Pubmed Data : J Mol Med (Berl). 2017 Oct ;95(10):1065-1076. Epub 2017 Jul 4. PMID: 28674855
Article Published Date : Sep 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Bone Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Osteoprotective
Additional Keywords : Anti-Inflammatory Agents, Antioxidants, Bone Diseases, Carnosic Acid, NF-kappaB Inhibitor, Osteoprotective
[+]

Carnosic acid cooperates with tamoxifen to induce apoptosis in breast cancer cells.Apr 30, 2017

Pubmed Data : Biomed Pharmacother. 2017 May ;89:827-837. Epub 2017 Mar 6. PMID: 28282784
Article Published Date : Apr 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation
Additional Keywords : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Breast Cancer, Carnosic Acid, Synergy with Tamoxifen
Problem Substances : Tamoxifen
[+]

Carnosic acid improves diabetic nephropathy.Jul 31, 2018

Pubmed Data : Phytomedicine. 2018 Aug 1 ;47:161-173. Epub 2018 Apr 17. PMID: 30166101
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Diabetic Nephropathy, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Nrf2 activation
[+]

Carnosic acid improves outcome after repetitive mild traumatic brain injury.Jun 30, 2019

Pubmed Data : J Neurotrauma. 2019 Jul 1 ;36(13):2147-2152. Epub 2019 Mar 26. PMID: 30672378
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Brain Injury: Traumatic
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Carnosic acid induces apoptosis of hepatocellular carcinoma cells.Oct 31, 2017

Pubmed Data : Chem Biol Interact. 2017 Nov 1 ;277:91-100. Epub 2017 Sep 13. PMID: 28918123
Article Published Date : Oct 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic
Additional Keywords : Antineoplastic Agents, Apoptotic, Carnosic Acid, liver cancer
[+]

Carnosic acid inhibits reactive oxygen species-dependent neutrophil extracellular trap formation and ameliorates acute respiratory distress syndrome.Dec 28, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Life Sci. 2022 Dec 29:121334. Epub 2022 Dec 29. PMID: 36587789
Article Published Date : Dec 28, 2022
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Acute Respiratory Distress Syndrome
Pharmacological Actions : Antioxidants
[+]

Carnosic acid is effective in the treatment of the established CCI-induced pain.Jan 18, 2016

Pubmed Data : Neurochem Int. 2016 Jan 19. Epub 2016 Jan 19. PMID: 26804443
Article Published Date : Jan 18, 2016
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Neuropathic Pain
Pharmacological Actions : Antinoceceptive
[+]

Carnosic acid may be an effective agent in protecting rats from NAFLD-induced dopaminergic neuron injury.Dec 12, 2016

Pubmed Data : Metab Brain Dis. 2016 Dec 13. Epub 2016 Dec 13. PMID: 27957651
Article Published Date : Dec 12, 2016
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Neuroprotective Agents
[+]

Carnosic acid may be prove to be a useful anti-NAFLD agent.Jun 30, 2018

Pubmed Data : Int J Mol Med. 2018 Jul ;42(1):193-207. Epub 2018 Mar 27. PMID: 29620148
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor
[+]

Carnosic acid may represent a novel therapeutic strategy to treat metabolic disease induced brain injury.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Jul ;20(1):495-504. Epub 2019 May 27. PMID: 31180544
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Brain Inflammation , High Fat Diet
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents
[+]

Carnosic acid mitigates depression-like behavior in ovariectomized mice.Jan 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Neurobiol. 2023 Feb ;60(2):610-628. Epub 2022 Nov 4. PMID: 36331794
Article Published Date : Jan 31, 2023
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Depression
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Carnosic acid mitigates early brain injury after subarachnoid hemorrhage.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurosci. 2019 ;13:26. Epub 2019 Mar 5. PMID: 30890904
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Subarachnoid hemorrhage
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Carnosic acid modulates increased hepatic lipogenesis and adipocytes differentiation in ovariectomized mice fed normal or high-fat diets.Dec 14, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Dec 15 ;10(12). Epub 2018 Dec 15. PMID: 30558262
Article Published Date : Dec 14, 2018
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Cardiovascular Diseases, High Fat Diet
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Carnosic acid protected against acetaminophen induced liver injury and enhanced antioxidant defence system.Dec 31, 2015

Pubmed Data : Korean J Physiol Pharmacol. 2016 Jan ;20(1):15-23. Epub 2015 Dec 31. PMID: 26807019
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

Carnosic acid protects against doxorubicin-induced cardiotoxicity.Apr 23, 2023

Pubmed Data : Food Funct. 2023 Apr 24 ;14(8):3849-3862. Epub 2023 Apr 24. PMID: 37013966
Article Published Date : Apr 23, 2023
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective, Chemoprotective Agents
[+]

Carnosic acid protects against lipopolysaccharide-induced acute lung injury in mice.Oct 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2019 Nov ;18(5):3707-3714. Epub 2019 Sep 23. PMID: 31611929
Article Published Date : Oct 31, 2019
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Carnosic acid resulted in apoptosis both in vitro and vivo experiments of cervical cancer. Jul 31, 2016

Pubmed Data : Biomed Pharmacother. 2016 Aug ;82:180-91. Epub 2016 May 10. PMID: 27470354
Article Published Date : Jul 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Carnosic acid suppressed the formation of NETs in alcoholic hepatosteatosis based on P2X7R-NLRP3 axis.Dec 13, 2022

Pubmed Data : Phytomedicine. 2022 Dec 14 ;110:154599. Epub 2022 Dec 14. PMID: 36577209
Article Published Date : Dec 13, 2022
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation
[+]

Carnosol and carnosic acid displayed significant and dose-dependent anti-inflammatory and anti-nociceptive effects.Jul 26, 2016

Pubmed Data : Br J Pharmacol. 2016 Jul 27. Epub 2016 Jul 27. PMID: 27464306
Article Published Date : Jul 26, 2016
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid, Carnosol
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive
Additional Keywords : Dose Response
[+]

Combination therapy of carnosic acid and methotrexate effectively suppressed the inflammatory markers and oxidative stress in experimental arthritis.Oct 20, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2022 Oct 21 ;27(20). Epub 2022 Oct 21. PMID: 36296709
Article Published Date : Oct 20, 2022
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Inflammation, Oxidative Stress, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Natural Substance/Drug Synergy
[+]

Effect of carnosic acid on acrylamide induced neurotoxicity.Nov 18, 2020

Pubmed Data : Drug Chem Toxicol. 2020 Nov 19:1-8. Epub 2020 Nov 19. PMID: 33213219
Article Published Date : Nov 18, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Acrylamide-induced toxicity
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents
Problem Substances : Acrylamide
[+]

Extracts from spearmint and rosemary have beneficial effects on learning and memory and brain tissue markers of oxidation.Aug 11, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Physiol Behav. 2016 Aug 12. Epub 2016 Aug 12. PMID: 27527000
Article Published Date : Aug 11, 2016
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid, Rosemary, Rosmarinic acid, Spearmint
Diseases : Aging: Brain , Brain: Oxidative Stress, Learning disorders, Memory Disorders
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Neuroprotection comparison of rosmarinic acid and carnosic acid in primary cultures of cerebellar granule neurons.Nov 12, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Nov 13 ;23(11). Epub 2018 Nov 13. PMID: 30428519
Article Published Date : Nov 12, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid, Rosmarinic acid
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
[+]

Protective effects of carnosic acid on retinal ganglion cells in acute ocular hypertension rats.Apr 09, 2020

Pubmed Data : Int Ophthalmol. 2020 Apr 10. Epub 2020 Apr 10. PMID: 32277323
Article Published Date : Apr 09, 2020
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Hypertension
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Rosemary derived carnosic acid is a promising natural compound for the treatment of rheumatoid arthritis.Jul 31, 2018

Pubmed Data : J Cell Physiol. 2018 Aug ;233(8):6291-6303. Epub 2018 Mar 9. PMID: 29521424
Article Published Date : Jul 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Arthritis, Neuropathic Pain
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Matrix metalloproteinase-3 (MMP-3) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Rosemary extract can be an effective preventative agent against inflammatory bowel disease.Feb 26, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2021 Feb 27 ;13(3). Epub 2021 Feb 27. PMID: 33673488
Article Published Date : Feb 26, 2021
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid, Carnosol, Rosemary
Diseases : Colitis, Inflammatory Bowel Diseases
Pharmacological Actions : Gastrointestinal Agents, Gastroprotective, Prophylactic Agents
[+]

Rosemary extract supplementation significantly reduced body weight gain, percent of fat, plasma ALT, AST, glucose, insulin levels, liver weight, liver triglyceride, and free fatty acid levels.May 19, 2015

Pubmed Data : J Agric Food Chem. 2015 May 20 ;63(19):4843-52. Epub 2015 May 8. PMID: 25929334
Article Published Date : May 19, 2015
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid, Rosemary
Diseases : Advanced Glycation End products (AGE), High Fat Diet, Obesity, Triglycerides: Elevated
Pharmacological Actions : Antioxidants, Hypolipidemic, Malondialdehyde Down-regulation
Additional Keywords : Anti-Obesity Agents, Plant Extracts
[+]

Rosmarinic acid showed a stronger protective effect than carnosic acid in mitigating diabetic symptoms in rats.Jan 25, 2018

Pubmed Data : Food Funct. 2018 Jan 26. Epub 2018 Jan 26. PMID: 29372208
Article Published Date : Jan 25, 2018
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid, Rosemaric Acid
Diseases : Diabetic Complications
Pharmacological Actions : Anti-Glycation Agents, Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation
Additional Keywords : Microbiota
[+]

Salvia officinalis, rosmarinic and caffeic acids attenuate neuropathic pain and improve function recovery after sciatic nerve chronic constriction.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:1702378. Epub 2019 Jun 24. PMID: 31341489
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid, Rosmarinic acid, Sage
Diseases : Neuropathic Pain, Sciatic Nerve Crush Injury
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

The present study revealed for the first time that carnosic acid has a protective effect against hepatocyte apoptosis in NAFLD.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2015 ;6:e1833. Epub 2015 Jul 23. PMID: 26203862
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, MicroRNA modulator, SIRT1 Activator
Additional Keywords : Significant Treatment Outcome
[+]

These findings support the rationale of using natural remedies in conjunction with classical pharmacological agents to treat chronic neuropathic pain.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:711. Epub 2019 Jun 27. PMID: 31316381
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene, Carnosic Acid, Myrrh, Palmitoylethanolamide
Diseases : Neuropathic Pain
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

These results suggest that carnosic acid and rosemary extract can be useful in the prevention of disorders due to angiogenesis.Dec 31, 2011

Pubmed Data : Biosci Biotechnol Biochem. 2012 ;76(1):115-9. Epub 2012 Jan 7. PMID: 22232247
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid, Carnosol, Rosemary
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Anti-Angiogenic, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

This study shows for the first time that carnosic acid and trastuzumab cooperate in inhibiting breast cancer cell migration and survival.Nov 02, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2017 Nov 3 ;36(1):154. Epub 2017 Nov 3. PMID: 29100552
Article Published Date : Nov 02, 2017
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Breast Cancer
Pharmacological Actions : Cell cycle arrest, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

A review of the anticancer effects of rosemary extract and rosemary extract polyphenols.Nov 16, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2016 Nov 17 ;8(11). Epub 2016 Nov 17. PMID: 27869665
Article Published Date : Nov 16, 2016
Study Type : Review
Additional Links
Substances : Carnosic Acid, Polyphenols, Rosemary, Rosmarinic acid
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiproliferative
Additional Keywords : Phytotherapy, Plant Extracts
[+]

A review of the dietary components carnosic acid and carnosol as neuroprotective agents.Oct 31, 2016

Pubmed Data : Mol Neurobiol. 2016 Nov ;53(9):6155-6168. Epub 2015 Nov 9. PMID: 26553346
Article Published Date : Oct 31, 2016
Study Type : Review
Additional Links
Substances : Carnosic Acid, Carnosol
Diseases : Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Anti-inflammatory effects of supercritical carbon dioxide extract and its isolated carnosic acid from Rosmarinus officinalis leaves.Apr 26, 2011

Pubmed Data : J Agric Food Chem. 2011 Apr 27 ;59(8):3674-85. Epub 2011 Mar 4. PMID: 21375325
Article Published Date : Apr 26, 2011
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Rosemary
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Anti-SARS-CoV-2 activities of tanshinone IIA, carnosic acid, rosmarinic acid, salvianolic acid, baicalein, and glycyrrhetinic acid between computational and in vitro insights.Aug 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : RSC Adv. 2021 Sep 1 ;11(47):29267-29286. Epub 2021 Sep 1. PMID: 35492070
Article Published Date : Aug 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Baicalein, Carnosic Acid, Rosemaric Acid, Tanshinone IIA
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Carnosic acid carnosol exert a protective effect against diabetes and fatty liver disease, as well as subsequent cases of hepatoma.Apr 13, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2021 Apr 14 ;22(8). Epub 2021 Apr 14. PMID: 33919842
Article Published Date : Apr 13, 2021
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Carnosol
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Gene Expression Regulation
[+]

Carnosic acid and carnosol display antioxidant and anti-prion properties.Apr 05, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2022 Apr 6 ;11(4). Epub 2022 Apr 6. PMID: 35453411
Article Published Date : Apr 05, 2022
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Carnosol
Diseases : Prion Diseases
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Carnosic acid and carnosol-enriched rosemary extracts have anti-proliferative activity on colon cancer cells.Dec 06, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 Dec 7 ;17(12). Epub 2016 Dec 7. PMID: 27941607
Article Published Date : Dec 06, 2016
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Rosemary
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative
[+]

Carnosic acid can alleviate H2O2-induced hepatocyte damage through the SIRT1 pathway.Jul 31, 2015

Pubmed Data : Can J Physiol Pharmacol. 2015 Aug ;93(8):625-31. Epub 2015 Mar 18. PMID: 26059423
Article Published Date : Jul 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Oxidative Stress
Pharmacological Actions : SIRT1 Activator
[+]

Carnosic acid combined with Adriamycin, has high potential to inhibit the growth of malignant cells in vivo.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Med. 2015 ;8(7):11708-17. Epub 2015 Jul 15. PMID: 26380008
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Acute Myeloid Leukemia
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Multidrug Resistance Gene Modulators
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin, Resistance Reversal
[+]

Carnosic acid encapsulated in albumin nanoparticles has been introduced as a promising formula for treating breast and colorectal cancer.Jun 24, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2022 Jun 25 ;27(13). Epub 2022 Jun 25. PMID: 35807348
Article Published Date : Jun 24, 2022
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Breast Cancer, Colorectal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors
[+]

Carnosic acid enhances sensitization against TRAIL-mediated apoptosis through the down-regulation of c-FLIP and Bcl-2 expression.Jan 29, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Jan 30 ;6(3):1556-68. PMID: 25596735
Article Published Date : Jan 29, 2015
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Breast Cancer: Triple Negative , Kidney Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, Tumor Suppressor Protein p53 Upregulation
[+]

Carnosic acid enhances the anti-lung cancer effect of cisplatin.Nov 30, 2018

Pubmed Data : Chin J Nat Med. 2018 Dec ;16(12):907-915. PMID: 30595215
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Carnosic acid enhances the cytotoxicity of β-lapachone in melanoma cell lines.Jan 31, 2018

Pubmed Data : Oncol Lett. 2018 Feb ;15(2):2393-2400. Epub 2017 Dec 14. PMID: 29434949
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Melanoma
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Carnosic acid has the potential to inhibit cancer cell growth in A-549 lung cancer cells.Oct 20, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2019 Oct 21 ;25:7864-7871. Epub 2019 Oct 21. PMID: 31631173
Article Published Date : Oct 20, 2019
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

Carnosic acid impedes cell growth and enhances anti-cancer effects of carmustine and lomustine in melanoma.May 21, 2018

Pubmed Data : Biosci Rep. 2018 May 22. Epub 2018 May 22. PMID: 29789400
Article Published Date : May 21, 2018
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Melanoma
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Carnosic acid induced apoptosis in HCT116 cells via generation of ROS, induction of p53, activation of caspases, and inhibition of STAT3 signaling pathway.Jul 07, 2015

Pubmed Data : Mol Carcinog. 2015 Jul 8. Epub 2015 Jul 8. PMID: 26152521
Article Published Date : Jul 07, 2015
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Rosemary
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-9 Activation, STAT3 Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Carnosic acid induces anti-inflammatory effects in paraquat-treated SH-SY5Y cells.Dec 31, 2017

Pubmed Data : Mol Neurobiol. 2018 Jan ;55(1):890-897. Epub 2017 Jan 12. PMID: 28083817
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Pesticide Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 inducer, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Paraquat
[+]

Carnosic acid induces apoptosis and inhibits Akt/mTOR signaling in human gastric cancer cell lines.Mar 07, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2021 Mar 8 ;14(3). Epub 2021 Mar 8. PMID: 33800129
Article Published Date : Mar 07, 2021
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Carnosic acid inhibits NLRP3 inflammasome activation by targeting both priming and assembly steps.Feb 28, 2023

Pubmed Data : Int Immunopharmacol. 2023 Mar ;116:109819. Epub 2023 Feb 2. PMID: 36738671
Article Published Date : Feb 28, 2023
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Carnosic acid inhibits secretion of allergic inflammatory mediators in IgE-activated mast cells.Jan 02, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biol Chem. 2023 Jan 3:102867. Epub 2023 Jan 3. PMID: 36608933
Article Published Date : Jan 02, 2023
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Allergies
Pharmacological Actions : Anti-Allergic Agents, Anti-Inflammatory Agents
[+]

Carnosic acid is a potential candidate to be listed as a neuroprotective agent by acting on the mitochondria of neural cells.Jan 14, 2018

Pubmed Data : Mol Neurobiol. 2018 Jan 15. Epub 2018 Jan 15. PMID: 29335845
Article Published Date : Jan 14, 2018
Study Type : Review
Additional Links
Substances : Carnosic Acid
Diseases : Alzheimer's Disease, Huntington Disease, Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Carnosic acid might be a prospective therapeutic drug for liver fibrosis.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2017 ;8:976. Epub 2018 Jan 19. PMID: 29403377
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator, NF-kappaB Inhibitor
[+]

Carnosic acid potentiates the anticancer effect of temozolomide by inducing apoptosis and autophagy in glioma.Nov 19, 2018

Pubmed Data : J Neurooncol. 2018 Nov 20. Epub 2018 Nov 20. PMID: 30460630
Article Published Date : Nov 19, 2018
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Glioma
Pharmacological Actions : Apoptotic, Autophagy Inhibitors, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Temozolomide
[+]

Carnosic acid prevents dextran sulfate sodium-induced acute colitis.Sep 07, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Sep 8 ;7(1):11036. Epub 2017 Sep 8. PMID: 28887507
Article Published Date : Sep 07, 2017
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Colitis
Pharmacological Actions : Antioxidants, Nrf2 activation
Additional Keywords : Antioxidants, Carnosic Acid, Colitis, Nrf2 activation
[+]

Carnosic acid promotes a profound deregulation of cell cycle control and reduces the survival of glioblastoma cells.Jun 14, 2016

Pubmed Data : Phytomedicine. 2016 Jun 15 ;23(7):679-85. Epub 2016 Apr 6. PMID: 27235706
Article Published Date : Jun 14, 2016
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Carnosic acid protected against starvation-induced SH-SY5Y cell death.Jul 18, 2016

Pubmed Data : Int J Food Sci Nutr. 2016 Jul 19:1-6. Epub 2016 Jul 19. PMID: 27435046
Article Published Date : Jul 18, 2016
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents, NF-E2-Related Factor-2 (Nrf2) Modulator
[+]

Carnosic acid protected retinal pigment epithelium cells from acrylamide-induced toxicity.Sep 30, 2017

Pubmed Data : Food Chem Toxicol. 2017 Oct ;108(Pt B):543-553. Epub 2017 Feb 1. PMID: 28159594
Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Acrylamide-induced toxicity
Pharmacological Actions : Antioxidants
Additional Keywords : Acrylamide-induced toxicity, Antioxidants, Carnosic Acid
Problem Substances : Acrylamide
[+]

Carnosic acid regulates cell proliferation and invasion in chronic myeloid leukemia cancer cells.Apr 30, 2018

Pubmed Data : J BUON. 2018 May-Jun;23(3):741-746. PMID: 30003745
Article Published Date : Apr 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, MicroRNA modulator
[+]

Carnosic acid suppresses the H2O2-induced mitochondria-related bioenergetics disturbances and redox impairment in SH-SY5Y cells.Jan 31, 2018

Pubmed Data : Mol Neurobiol. 2018 Feb ;55(2):968-979. Epub 2017 Jan 13. PMID: 28084591
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Carnosic acid, a component found within Rosemary, inhibits HIV-1 protease. Aug 01, 1993

Pubmed Data : J Nat Prod. 1993 Aug;56(8):1426-30. PMID: 8229021
Article Published Date : Aug 01, 1993
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Rosemary
Diseases : HIV Infections
Pharmacological Actions : HIV Protease Inhibitors
[+]

Carnosic acid, a compound within Rosemary, stimulates nerve growth factor in human glioblastoma cells. Oct 01, 2004

Pubmed Data : Mol Cancer Ther. 2004 Oct;3(10):1239-48. PMID: 14600414
Article Published Date : Oct 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Rosemary
Diseases : Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Neuritogenic
[+]

Carnosol and carnosic acid exhibit antioxidant and antiproliferative activities in a concentration-dependent manner.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:7623830. Epub 2019 Nov 16. PMID: 31827560
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Carnosol, Rosemary
Diseases : Oxidative Stress
Therapeutic Actions : Dietary Modification: Mediterranean Diet
Pharmacological Actions : Antioxidants, Antiproliferative
[+]

Effects of rosmarinic acid, carnosic acid, rosmanol, carnosol, and ursolic acid on the pathogenesis of respiratory diseases.Dec 22, 2022

Pubmed Data : Biofactors. 2022 Dec 23. Epub 2022 Dec 23. PMID: 36564953
Article Published Date : Dec 22, 2022
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Carnosol, Rosmarinic acid, Ursolic Acid
Diseases : Respiratory Diseases
Pharmacological Actions : Anti-Inflammatory Agents, interleukin-13 down-regulation, Interleukin-4 downregulation, Interleukin-5 downregulation
[+]

Enhancement of sorafenib-mediated death of hepatocellular carcinoma cells by carnosic acid and vitamin D2 analog combination.Nov 04, 2019

Pubmed Data : J Steroid Biochem Mol Biol. 2019 Nov 5:105524. Epub 2019 Nov 5. PMID: 31704246
Article Published Date : Nov 04, 2019
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Vitamin D
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
Additional Keywords : Chemothapeutic Synergy: Sorafenib, Vitamin D2
[+]

Enhancing antioxidant and antimicrobial activity of carnosic acid in rosemary extract by complexation with cyclic glucans.Nov 29, 2019

Pubmed Data : Food Chem. 2019 Nov 30 ;299:125119. Epub 2019 Jul 2. PMID: 31295638
Article Published Date : Nov 29, 2019
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Rosemary
Pharmacological Actions : Antimicrobial, Antioxidants
[+]

Hypersensitivity of BRCA2 deficient cells to rosemary extract explained by weak PARP inhibitory activity.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Dec 1 ;7(1):16704. Epub 2017 Dec 1. PMID: 29196727
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Gallic Acid, Rosemary
Diseases : Lung Cancer
Pharmacological Actions : Cytotoxic
Additional Keywords : BRCA Gene, Plant Extracts
[+]

Induction of ferroptosis by carnosic acid-mediated inactivation of Nrf2/HO-1 potentiates cisplatin responsiveness in OSCC cells.Apr 28, 2022

Pubmed Data : Mol Cell Probes. 2022 Apr 29 ;64:101821. Epub 2022 Apr 29. PMID: 35490795
Article Published Date : Apr 28, 2022
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Induction of G2/M phase cell cycle arrest by carnosol and carnosic acid is associated with alteration of cyclin A and cyclin B1 levels.Jun 07, 2006

Pubmed Data : Cancer Lett. 2006 Jun 8 ;237(1):130-6. Epub 2005 Jul 14. PMID: 16019137
Article Published Date : Jun 07, 2006
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Colorectal Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cell cycle arrest
Additional Keywords : Plant Extracts
[+]

Interaction mechanism of carnosic acid against glycosidase (α-amylase and α-glucosidase).Jul 25, 2019

Pubmed Data : Int J Biol Macromol. 2019 Jul 26. Epub 2019 Jul 26. PMID: 31356939
Article Published Date : Jul 25, 2019
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Hyperglycemia
Pharmacological Actions : Alpha-amylase inhibitor, Alpha-glucosidase inhibitor , Hypoglycemic Agents
[+]

Neuroprotective effects of carnosic acid: insight into its mechanisms of action.Mar 01, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2023 Mar 2 ;28(5). Epub 2023 Mar 2. PMID: 36903551
Article Published Date : Mar 01, 2023
Study Type : Review
Additional Links
Substances : Carnosic Acid
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Polyphenol antioxidants have properties to treat neurodegenerative diseases.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Basic Clin Neurosci. 2016 Apr ;7(2):81-90. PMID: 27303602
Article Published Date : Mar 31, 2016
Study Type : Review
Additional Links
Substances : Allicin, Carnosic Acid, Curcumin, EGCG (Epigallocatechin gallate), Isothiocyanate, Quercetin, Resveratrol, Rosmarinic acid, Sulforaphane
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Polyphenols from the Mediterranean herb rosemary for prostate cancer.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2013 ;4:29. Epub 2013 Mar 25. PMID: 23531917
Article Published Date : Dec 31, 2012
Study Type : Review
Additional Links
Substances : Carnosic Acid, Carnosol, Rosemary
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest
[+]

Prevention and treatment of influenza, influenza-like illness, and common cold by herbal, complementary, and natural therapies.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Evid Based Complementary Altern Med. 2017 Jan ;22(1):166-174. Epub 2016 Apr 6. PMID: 27055821
Article Published Date : Dec 31, 2016
Study Type : Review
Additional Links
Substances : Carnosic Acid, Echinacea, Ginseng (American), Guava, Licorice, Pomegranate, Probiotics, Vitamin C, Zinc
Diseases : Common Cold, Influenza
Therapeutic Actions : Dietary Modification: Less Acid/More Alkaline Foods, Grounding: Contact with the Earth
Pharmacological Actions : Antiviral Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Protective effects of carnosic acid against mitochondria-mediated injury in H9c2 cardiomyocytes induced by hypoxia/reoxygenation.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Dec ;14(6):5629-5634. Epub 2017 Oct 2. PMID: 29285102
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Hypoxia, Ischemia: Myocardial
Pharmacological Actions : Cardioprotective
Additional Keywords : Cardioprotective, Carnosic Acid, Hypoxia, Ischemia: Myocardial
[+]

Rosemary protects dopaminergic neuronal cellsAug 27, 2008

Pubmed Data : Neuroreport. 2008 Aug 27;19(13):1301-4. PMID: 18695511
Article Published Date : Aug 27, 2008
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Rosemary
Diseases : Parkinson's Disease
[+]

Rosemary/carnosic acid, alone or combined with curcumin, may be useful to prevent and treat ER-negative breast cancer.Sep 30, 2012

Pubmed Data : Fitoterapia. 2012 Oct ;83(7):1160-8. Epub 2012 Jul 22. PMID: 22828666
Article Published Date : Sep 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Curcumin, Rosemary
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Gene Expression Regulation, Natural Substance Synergy, Plant Extracts
[+]

Rosmarinic acid and carnosic acid could prevent the formation of advanced glycation end-products in vitro. Apr 14, 2017

Pubmed Data : Food Chem. 2017 Apr 15 ;221:1057-1061. Epub 2016 Nov 11. PMID: 27979058
Article Published Date : Apr 14, 2017
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Rosemary, Rosmarinic acid
Diseases : Advanced Glycation End products (AGE)
Pharmacological Actions : Anti-Glycation Agents
Additional Keywords : Plant Extracts
[+]

Rosmarinic acid potentiates carnosic acid induced apoptosis in lung fibroblasts.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(9):e0184368. Epub 2017 Sep 6. PMID: 28877257
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Rosemaric Acid
Diseases : Fibrosis
Pharmacological Actions : Apoptotic, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

Rosmarinus officinalis L.: an update review of its phytochemistry and biological activity.Mar 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Future Sci OA. 2018 Apr ;4(4):FSO283. Epub 2018 Feb 1. PMID: 29682318
Article Published Date : Mar 31, 2018
Study Type : Review
Additional Links
Substances : Carnosic Acid, Carnosol, Rosemary, Rosmarinic acid
Diseases : Alzheimer's Disease, Depression, Inflammation, Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Analgesics, Anti-Bacterial Agents, Anti-Infective Agents, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Specific inhibition of S. aureus virulence using topical formulations of rosemary extract may offer a practical approach to preventing and treating flares of atopic dermatitis.Mar 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antibiotics (Basel). 2020 Mar 31 ;9(4). Epub 2020 Mar 31. PMID: 32244277
Article Published Date : Mar 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Carnosol, Rosemary
Diseases : Atopic Dermatitis, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents, Quorum Sensing Inhibition
[+]

The activation of EpRE/ARE system was up to four fold higher than the sum of the activities of the single ingredients. Apr 14, 2015

Pubmed Data : Arch Biochem Biophys. 2015 Apr 15 ;572:28-35. Epub 2015 Feb 21. PMID: 25711533
Article Published Date : Apr 14, 2015
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Carotenoids, Curcumin, Flavonoids, Lycopene, Polyphenols
Diseases : Cancers: All, Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antioxidants, Antiproliferative
Additional Keywords : Natural Substance Synergy
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The carnosic acid content was increased by silver nanoparticle treatment in rosemary.Dec 03, 2019

Pubmed Data : Appl Biochem Biotechnol. 2019 Dec 4. Epub 2019 Dec 4. PMID: 31797151
Article Published Date : Dec 03, 2019
Study Type : Plant Study
Additional Links
Substances : Carnosic Acid, Rosemary, Silver (nanoparticles)
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
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The protective role of carnosic acid in ischemic/reperfusion injury through regulation of autophagy under T2DM.Apr 30, 2019

Pubmed Data : Exp Biol Med (Maywood). 2019 May ;244(7):602-611. Epub 2019 Apr 4. PMID: 30947537
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Diabetes Mellitus: Type 2, Myocardial Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective
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This review summarizes the results related to the chemopreventive and radioprotective properties of Tulsi.Dec 31, 2012

Pubmed Data : Nutr Cancer. 2013 ;65 Suppl 1:26-35. PMID: 23682780
Article Published Date : Dec 31, 2012
Study Type : Review
Additional Links
Substances : Apigenin, Carnosic Acid, Eugenol, Holy Basil, Rosemaric Acid
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive, Radioprotective
Additional Keywords : Plant Extracts
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Treatment with carnosic acid-rich rosemary extract and 1,25D3 analogs results in strong cooperative antileukemic effects.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 ;17(7). Epub 2016 Jul 5. PMID: 27399677
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Vitamin D
Diseases : Acute Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Cell cycle arrest
Additional Keywords : Natural Substance Synergy, Vitamin D2

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