Carnosic Acid

Name	AC	CK
Oxidative Stress	9	13
Alzheimer's Disease	5	9
Inflammation	6	9
Parkinson's Disease	6	9
Brain Inflammation	4	8
High Fat Diet	4	8
Neurodegenerative Diseases	6	8
Neuropathic Pain	4	8
Brain: Oxidative Stress	3	7
Chemotherapy-Induced Toxicity: Doxorubicin	3	6
Nonalcoholic fatty liver disease (NAFLD)	3	6
Acrylamide-induced toxicity	3	5
Breast Cancer	3	5
Liver Cancer	4	5
Lung Cancer	4	5
Osteoarthritis	1	5
Brain Injury: Traumatic	2	4
Colon Cancer	3	4
Lipopolysaccharide-Induced Toxicity	3	4
Obesity	2	4
Rheumatoid Arthritis	2	4
Advanced Glycation End products (AGE)	2	3
Cancers: All	3	3
Colitis	2	3
Depression	2	3
Pesticide Toxicity	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Acute Myeloid Leukemia	2	2
Acute Respiratory Distress Syndrome	1	2
Aging: Brain	1	2
Alcoholic Liver Disease	1	2
Amyotrophic lateral sclerosis (ALS)	1	2
Arthritis	1	2
Bisphenol Toxicity	1	2
Bone Diseases	1	2
Breast Cancer: Triple Negative	2	2
Carcinoma: Non-Small-Cell Lung	2	2
Cardiovascular Diseases	1	2
Cervical Cancer	1	2
Chemically-Induced Liver Damage	1	2
Colon Cancer: Prevention	1	2
Colorectal Cancer	2	2
Diabetic Complications	1	2
Diabetic Nephropathy	1	2
Eye Damage	1	2
Fibrosis	2	2
Gastric Ulcer	1	2
Hydrogen Peroxide Induced Toxicity	2	2
Hypertension	1	2
Inflammatory Bowel Diseases	1	2
Kidney Damage: Chemically-Induced	1	2
Learning disorders	1	2
Lung Injury: Acute	1	2
Melanoma	2	2
Memory Disorders	1	2
Prostate Cancer	2	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Sciatic Nerve Crush Injury	1	2
Subarachnoid hemorrhage	1	2
Triglycerides: Elevated	1	2
Allergies	1	1
Atopic Dermatitis	1	1
Chronic Myeloid Leukemia	1	1
Common Cold	1	1
Coronavirus Infection	1	1
Diabetes Mellitus: Type 2	1	1
Endometriosis	1	1
Gastric Cancer	1	1
Glioblastoma	1	1
Glioma	1	1
HIV Infections	1	1
Herpes Simplex Virus Type 2	1	1
Huntington Disease	1	1
Hyperglycemia	1	1
Hypoxia	1	1
Influenza	1	1
Ischemia: Myocardial	1	1
Kidney Cancer	1	1
Myocardial Ischemia	1	1
Oral Cancer	1	1
Prion Diseases	1	1
Respiratory Diseases	1	1
Squamous cell carcinoma	1	1
Staphylococcus aureus infection	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1

Name	AC	CK
Antioxidants	37	64
Anti-Inflammatory Agents	31	52
Neuroprotective Agents	23	39
Antiproliferative	21	24
Apoptotic	19	24
Anti-Apoptotic	11	22
Nrf2 activation	10	18
Interleukin-1 beta downregulation	9	17
Interleukin-6 Downregulation	7	14
NF-kappaB Inhibitor	7	12
Tumor Necrosis Factor (TNF) Alpha Inhibitor	7	12
Heme oxygenase-1 up-regulation	4	11
Hepatoprotective	5	10
Cardioprotective	5	8
Cell cycle arrest	7	8
Chemoprotective Agents	4	8
Chemotherapeutic	6	7
Osteoprotective	2	7
Malondialdehyde Down-regulation	3	6
Bcl-2 protein down-regulation	4	5
SIRT1 Activator	3	5
Antineoplastic Agents	3	4
Antinoceceptive	2	4
Gastrointestinal Agents	2	4
Hypolipidemic	2	4
MicroRNA modulator	3	4
Analgesics	2	3
Anti-Bacterial Agents	3	3
Anti-Fibrotic	2	3
Anti-Glycation Agents	2	3
Antiviral Agents	3	3
Chemopreventive	2	3
Cyclooxygenase 2 Inhibitors	3	3
Superoxide Dismutase Up-regulation	2	3
Anti-Angiogenic	1	2
Anti-Ulcer Agents	1	2
Anti-metastatic	2	2
Anticarcinogenic Agents	1	2
Antidepressive Agents	1	2
Autophagy Up-regulation	2	2
Bcl-xL down-regulation	1	2
Chemosensitizer	2	2
Gastroprotective	1	2
Immunomodulatory	2	2
Interleukin-17 downregulation	1	2
Interleukin-8 downregulation	1	2
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	2
Neurogenesis	1	2
Prophylactic Agents	1	2
Renoprotective	1	2
Tumor Suppressor Protein p53 Upregulation	2	2
Alpha-amylase inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Anti-Allergic Agents	1	1
Anti-Infective Agents	1	1
Antimicrobial	1	1
Autophagy Inhibitors	1	1
Caspase-3 Activation	1	1
Caspase-9 Activation	1	1
Cytotoxic	1	1
HIV Protease Inhibitors	1	1
Heme oxygenase-1 inducer	1	1
Hypoglycemic Agents	1	1
Interleukin-4 downregulation	1	1
Interleukin-5 downregulation	1	1
Multidrug Resistance Gene Modulators	1	1
NF-E2-Related Factor-2 (Nrf2) Modulator	1	1
Neuritogenic	1	1
Quorum Sensing Inhibition	1	1
Radioprotective	1	1
STAT3 Inhibitor	1	1
Vascular Endothelial Growth Factor Inhibitors	1	1
interleukin-13 down-regulation	1	1

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Carnosic acid attenuates cartilage degeneration in human articular chondrocytes.Jul 04, 2018

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Pubmed Data : Eur J Pharmacol. 2018 Jul 5 ;830:1-8. Epub 2018 Apr 17. PMID: 29678719

Article Published Date : Jul 04, 2018

Study Type : Human In Vitro

Additional Links

Substances : Carnosic Acid

Diseases : Osteoarthritis

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Osteoprotective

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Multi-target effects of ß-caryophyllene and carnosic acid at the crossroads of mitochondrial dysfunction and neurodegeneration.Jun 17, 2022

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Pubmed Data : Antioxidants (Basel). 2022 Jun 18 ;11(6). Epub 2022 Jun 18. PMID: 35740096

Article Published Date : Jun 17, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Beta-Caryophyllene, Carnosic Acid

Diseases : Alzheimer's Disease, Brain: Oxidative Stress, Brain Inflammation , Parkinson's Disease

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents, Nrf2 activation

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Alteration of gut microbiota in high-fat diet-induced obese mice using carnosic acid from rosemary.Jun 30, 2022

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Pubmed Data : J Mol Med (Berl). 2017 Oct ;95(10):1065-1076. Epub 2017 Jul 4. PMID: 28674855

Article Published Date : Sep 30, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Carnosic Acid

Diseases : Bone Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Osteoprotective

Additional Keywords : Anti-Inflammatory Agents, Antioxidants, Bone Diseases, Carnosic Acid, NF-kappaB Inhibitor, Osteoprotective

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Carnosic acid cooperates with tamoxifen to induce apoptosis in breast cancer cells.Apr 30, 2017

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Pubmed Data : Biomed Pharmacother. 2017 May ;89:827-837. Epub 2017 Mar 6. PMID: 28282784

Article Published Date : Apr 30, 2017

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Co-delivery of curcumin-resveratrol-carnosic acid complex promotes neurogenesis and cognitive recovery in a rodent model of repeated mild traumatic brain injury.Jan 31, 2025

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Pubmed Data : Biomed Pharmacother. 2025 Feb ;183:117818. Epub 2025 Jan 17. PMID: 39826355

Article Published Date : Jan 31, 2025

Study Type : Animal Study

Additional Links

Substances : Carnosic Acid, Curcumin, Resveratrol

Diseases : Brain Injury: Traumatic

Pharmacological Actions : Neurogenesis, Neuroprotective Agents

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Combination therapy of carnosic acid and methotrexate effectively suppressed the inflammatory markers and oxidative stress in experimental arthritis.Oct 20, 2022

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These findings support the rationale of using natural remedies in conjunction with classical pharmacological agents to treat chronic neuropathic pain.Dec 31, 2018

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Pubmed Data : Nutrients. 2016 Nov 17 ;8(11). Epub 2016 Nov 17. PMID: 27869665

Article Published Date : Nov 16, 2016

Study Type : Review

Additional Links

Substances : Carnosic Acid, Polyphenols, Rosemary, Rosmarinic acid

Diseases : Cancers: All

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiproliferative

Additional Keywords : Phytotherapy, Plant Extracts

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A review of the dietary components carnosic acid and carnosol as neuroprotective agents.Oct 31, 2016

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Pubmed Data : Mol Neurobiol. 2016 Nov ;53(9):6155-6168. Epub 2015 Nov 9. PMID: 26553346

Article Published Date : Oct 31, 2016

Study Type : Review

Additional Links

Substances : Carnosic Acid, Carnosol

Diseases : Brain Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

[+]

Anti-biofilm activity of carnosic acid from Salvia rosmarinus against methicillin-resistant Staphylococcus aureus.Oct 24, 2023

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Pubmed Data : Sci Rep. 2017 Sep 8 ;7(1):11036. Epub 2017 Sep 8. PMID: 28887507

Article Published Date : Sep 07, 2017

Study Type : In Vitro Study

Additional Links

Substances : Carnosic Acid

Diseases : Colitis

Pharmacological Actions : Antioxidants, Nrf2 activation

Additional Keywords : Antioxidants, Carnosic Acid, Colitis, Nrf2 activation

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Carnosic acid regulates cell proliferation and invasion in chronic myeloid leukemia cancer cells.Apr 30, 2018

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Pubmed Data : J BUON. 2018 May-Jun;23(3):741-746. PMID: 30003745

Article Published Date : Apr 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Carnosic Acid

Diseases : Chronic Myeloid Leukemia

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, MicroRNA modulator

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Carnosic acid shows higher neuroprotective efficiency than edaravone or ebselen in in vitro models of neuronal cell damage.Dec 23, 2023

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Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:7623830. Epub 2019 Nov 16. PMID: 31827560

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2017 Dec 1 ;7(1):16704. Epub 2017 Dec 1. PMID: 29196727

Article Published Date : Nov 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Carnosic Acid, Gallic Acid, Rosemary

Diseases : Lung Cancer

Pharmacological Actions : Cytotoxic

Additional Keywords : BRCA Gene, Plant Extracts

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Protective effects of carnosic acid against mitochondria-mediated injury in H9c2 cardiomyocytes induced by hypoxia/reoxygenation.Nov 30, 2017

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Pubmed Data : Exp Ther Med. 2017 Dec ;14(6):5629-5634. Epub 2017 Oct 2. PMID: 29285102

Article Published Date : Nov 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Carnosic Acid

Diseases : Hypoxia, Ischemia: Myocardial

Pharmacological Actions : Cardioprotective

Additional Keywords : Cardioprotective, Carnosic Acid, Hypoxia, Ischemia: Myocardial

[+]

Rosemary protects dopaminergic neuronal cellsAug 27, 2008

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2016 ;17(7). Epub 2016 Jul 5. PMID: 27399677

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Carnosic Acid, Vitamin D

Diseases : Acute Myeloid Leukemia

Pharmacological Actions : Antiproliferative , Cell cycle arrest

Additional Keywords : Natural Substance Synergy, Vitamin D2

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View the Evidence: 112 Abstracts with Carnosic Acid Research

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Carnosic acid attenuates cartilage degeneration in human articular chondrocytes.Jul 04, 2018

Multi-target effects of ß-caryophyllene and carnosic acid at the crossroads of mitochondrial dysfunction and neurodegeneration.Jun 17, 2022

Alteration of gut microbiota in high-fat diet-induced obese mice using carnosic acid from rosemary.Jun 30, 2022

Both rosemary extracts administrated alone or in combination alleviated synergistically lung fibrosis.Oct 15, 2020

Carnosic acid alleviates chlorpyrifos-induced oxidative stress and inflammation in mice cerebral and ocular tissues.Jan 21, 2020

Carnosic acid alleviates levodopa-induced dyskinesia and cell death.Dec 31, 2020

Carnosic acid ameliorates indomethacin-induced gastric ulceration.Mar 08, 2023

Carnosic acid and fisetin combination therapy enhances inhibition of lung cancer through apoptosis induction.Apr 19, 2017

Carnosic acid and rosemary extract reversed the lipid accumulation induced by bisphenol A.Aug 31, 2023

Carnosic acid appears to alleviate adipocity-related acceleration of colon tumor formation.Nov 30, 2014

Carnosic acid attenuates acrylamide-induced retinal toxicity in zebrafish embryos.Jan 09, 2018

Carnosic acid attenuates arsenic-induced hepatotoxicity.Dec 31, 2017

Carnosic acid attenuates AβOs-induced apoptosis and synaptic impairment.Dec 31, 2022

Carnosic acid attenuates cadmium induced nephrotoxicity.Nov 17, 2019

Carnosic acid attenuates collagen-induced arthritis.Mar 22, 2017

Carnosic acid attenuates doxorubicin-induced cardiotoxicity.Jul 31, 2022

Carnosic acid attenuates RANKL-induced oxidative stress and osteoclastogenesis.Sep 30, 2017

Carnosic acid cooperates with tamoxifen to induce apoptosis in breast cancer cells.Apr 30, 2017

Carnosic acid improves diabetic nephropathy.Jul 31, 2018

Carnosic acid improves outcome after repetitive mild traumatic brain injury.Jun 30, 2019

Carnosic acid induces apoptosis of hepatocellular carcinoma cells.Oct 31, 2017

Carnosic acid inhibits reactive oxygen species-dependent neutrophil extracellular trap formation and ameliorates acute respiratory distress syndrome.Dec 28, 2022

Carnosic acid is effective in the treatment of the established CCI-induced pain.Jan 18, 2016

Carnosic acid may be an effective agent in protecting rats from NAFLD-induced dopaminergic neuron injury.Dec 12, 2016

Carnosic acid may be prove to be a useful anti-NAFLD agent.Jun 30, 2018

Carnosic acid may represent a novel therapeutic strategy to treat metabolic disease induced brain injury.Jun 30, 2019

Carnosic acid mitigates depression-like behavior in ovariectomized mice.Jan 31, 2023

Carnosic acid mitigates doxorubicin-induced cardiac toxicity.Dec 31, 2023

Carnosic acid mitigates early brain injury after subarachnoid hemorrhage.Dec 31, 2018

Carnosic acid modulates increased hepatic lipogenesis and adipocytes differentiation in ovariectomized mice fed normal or high-fat diets.Dec 14, 2018

Carnosic acid protected against acetaminophen induced liver injury and enhanced antioxidant defence system.Dec 31, 2015

Carnosic acid protects against doxorubicin-induced cardiotoxicity.Apr 23, 2023

Carnosic acid protects against lipopolysaccharide-induced acute lung injury in mice.Oct 31, 2019

Carnosic acid resulted in apoptosis both in vitro and vivo experiments of cervical cancer. Jul 31, 2016

Carnosic acid suppressed the formation of NETs in alcoholic hepatosteatosis based on P2X7R-NLRP3 axis.Dec 13, 2022

Carnosol and carnosic acid displayed significant and dose-dependent anti-inflammatory and anti-nociceptive effects.Jul 26, 2016

Co-delivery of curcumin-resveratrol-carnosic acid complex promotes neurogenesis and cognitive recovery in a rodent model of repeated mild traumatic brain injury.Jan 31, 2025

Combination therapy of carnosic acid and methotrexate effectively suppressed the inflammatory markers and oxidative stress in experimental arthritis.Oct 20, 2022

Effect of carnosic acid on acrylamide induced neurotoxicity.Nov 18, 2020

Extracts from spearmint and rosemary have beneficial effects on learning and memory and brain tissue markers of oxidation.Aug 11, 2016

Neuroprotection comparison of rosmarinic acid and carnosic acid in primary cultures of cerebellar granule neurons.Nov 12, 2018

Protective effects of carnosic acid on retinal ganglion cells in acute ocular hypertension rats.Apr 09, 2020

Rosemary derived carnosic acid is a promising natural compound for the treatment of rheumatoid arthritis.Jul 31, 2018

Rosemary extract can be an effective preventative agent against inflammatory bowel disease.Feb 26, 2021

Rosemary extract supplementation significantly reduced body weight gain, percent of fat, plasma ALT, AST, glucose, insulin levels, liver weight, liver triglyceride, and free fatty acid levels.May 19, 2015

Rosmarinic acid showed a stronger protective effect than carnosic acid in mitigating diabetic symptoms in rats.Jan 25, 2018

Salvia officinalis, rosmarinic and caffeic acids attenuate neuropathic pain and improve function recovery after sciatic nerve chronic constriction.Dec 31, 2018

The present study revealed for the first time that carnosic acid has a protective effect against hepatocyte apoptosis in NAFLD.Dec 31, 2014

These findings support the rationale of using natural remedies in conjunction with classical pharmacological agents to treat chronic neuropathic pain.Dec 31, 2018

These results suggest that carnosic acid and rosemary extract can be useful in the prevention of disorders due to angiogenesis.Dec 31, 2011

This study shows for the first time that carnosic acid and trastuzumab cooperate in inhibiting breast cancer cell migration and survival.Nov 02, 2017

A review of the anticancer effects of rosemary extract and rosemary extract polyphenols.Nov 16, 2016

A review of the dietary components carnosic acid and carnosol as neuroprotective agents.Oct 31, 2016

Anti-biofilm activity of carnosic acid from Salvia rosmarinus against methicillin-resistant Staphylococcus aureus.Oct 24, 2023

Anti-inflammatory effects of supercritical carbon dioxide extract and its isolated carnosic acid from Rosmarinus officinalis leaves.Apr 26, 2011

Anti-SARS-CoV-2 activities of tanshinone IIA, carnosic acid, rosmarinic acid, salvianolic acid, baicalein, and glycyrrhetinic acid between computational and in vitro insights.Aug 31, 2021

Carnosic acid carnosol exert a protective effect against diabetes and fatty liver disease, as well as subsequent cases of hepatoma.Apr 13, 2021

Carnosic acid against lung cancer: induction of autophagy and activation of sestrin-2/LKB1/AMPK signalling.Feb 05, 2024

Carnosic acid and carnosol display antioxidant and anti-prion properties.Apr 05, 2022

Carnosic acid and carnosol-enriched rosemary extracts have anti-proliferative activity on colon cancer cells.Dec 06, 2016

Carnosic acid can alleviate H2O2-induced hepatocyte damage through the SIRT1 pathway.Jul 31, 2015

Carnosic acid combined with Adriamycin, has high potential to inhibit the growth of malignant cells in vivo.Dec 31, 2014

Carnosic acid encapsulated in albumin nanoparticles has been introduced as a promising formula for treating breast and colorectal cancer.Jun 24, 2022

Carnosic acid enhances sensitization against TRAIL-mediated apoptosis through the down-regulation of c-FLIP and Bcl-2 expression.Jan 29, 2015

Carnosic acid enhances the anti-lung cancer effect of cisplatin.Nov 30, 2018

Carnosic acid enhances the cytotoxicity of β-lapachone in melanoma cell lines.Jan 31, 2018

Carnosic acid has the potential to inhibit cancer cell growth in A-549 lung cancer cells.Oct 20, 2019

Carnosic acid impedes cell growth and enhances anti-cancer effects of carmustine and lomustine in melanoma.May 21, 2018

Carnosic acid induced apoptosis in HCT116 cells via generation of ROS, induction of p53, activation of caspases, and inhibition of STAT3 signaling pathway.Jul 07, 2015

Carnosic acid induces anti-inflammatory effects in paraquat-treated SH-SY5Y cells.Dec 31, 2017

Carnosic acid induces apoptosis and inhibits Akt/mTOR signaling in human gastric cancer cell lines.Mar 07, 2021

Carnosic acid inhibits herpes simplex virus replication.May 02, 2024

Carnosic Acid

View the Evidence:
112 Abstracts with Carnosic Acid Research