Carvacrol

Name	AC	CK
Inflammation	13	31
Oxidative Stress	16	31
Asthma	3	22
Parkinson's Disease	8	22
Chemical Weapon Agent Injury: Sulfur Mustard	2	20
Lipopolysaccharide-Induced Toxicity	8	15
C-Reactive Protein	1	10
Chemically-Induced Liver Damage	5	10
Staphylococcus aureus infection	7	8
Hypertension	4	7
Chemotherapy-Induced Toxicity: Doxorubicin	3	6
Kidney Damage: Chemically-Induced	3	6
Breast Cancer	5	5
Candida Albicans	5	5
Candida Infection	1	5
DNA damage	1	5
Diabetic Complications	3	5
Lipid Peroxidation	1	5
Acinetobacter baumannii infection	2	4
Alzheimer's Disease	3	4
Brain Inflammation	2	4
Brain: Oxidative Stress	2	4
Cerebral Ischemia	2	4
Chemotherapy-Induced Toxicity: Cisplatin	2	4
Diabetes Mellitus: Type 2	2	4
Liver Cancer	2	4
Liver Damage: Drug-Induced	2	4
Liver Fibrosis	2	4
Memory Disorders	2	4
Pesticide Toxicity	2	4
Prostate Cancer	4	4
Salmonella Infections	4	4
Acetaminophen (Tylenol) Toxicity	2	3
Cadmium Poisoning	2	3
Carcinoma: Non-Small-Cell Lung	3	3
Clostridium Infections	2	3
Coronavirus Infection	3	3
Gastric Cancer	2	3
Hyperglycemia	2	3
Infection: Antibiotic Resistant	3	3
Leishmaniasis	2	3
Multiple Sclerosis	2	3
Mycobacterium tuberculosis	3	3
Neurodegenerative Diseases	2	3
Rheumatoid Arthritis	2	3
Sepsis	2	3
Staphylococcus aureus: Methicillin-resistant (MRSA)	2	3
Wound Healing	2	3
ALT: Elevated	1	2
Acrylamide-induced toxicity	1	2
Aging	1	2
Alcohol Toxicity	1	2
Alcoholic Liver Disease	1	2
Anxiety	1	2
Benzo[a]pyrene-induced Toxicity	1	2
Brain Injury: Traumatic	1	2
Cancers: Drug Resistant	2	2
Candidiasis	2	2
Cardiac Hypertrophy	1	2
Cardiomyopathy	1	2
Cerebral Hypoperfusion	1	2
Cervical Cancer	2	2
Chemotherapy-Induced Kidney Damage	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Paclitaxel	1	2
Chronic Obstructive Pulmonary Disease	1	2
Cognitive Decline/Dysfunction	1	2
Colitis	1	2
Dementia	1	2
Depression	1	2
Diabetes Mellitus: Type 1	1	2
Diabetes: Sexual Dysfunction/Reproduction	1	2
Drug-Induced Toxicity: Methotrexate	1	2
Dysbiosis	1	2
Dyslipidemias	1	2
Formaldehyde Toxicity	1	2
Gamma-glutamyl transpeptidase: Elevated	1	2
Influenza A	1	2
Lead Poisoning	1	2
Learning disorders	1	2
Liver Damage	1	2
Liver Disease	1	2
Mercury Poisoning	1	2
Nephrolithiasis	1	2
Ovarian Failure	1	2
Paraquat Toxicity	1	2
Phthalate Toxicity	1	2
Pseudomonas aeruginosa	2	2
Radiotherapy	1	2
Seizures	1	2
Steptococcus Mutans Infections	2	2
Streptococcus pyogenes	2	2
Testicular Injury: Chemical/Metal Induced	1	2
Traumatic Brain Injury	1	2
Xenobiotic Exposures	1	2
Acute Myeloid Leukemia	1	1
Aeromonas hydrophila	1	1
Aluminum Toxicity	1	1
Bacillus subtilis infections	1	1
Breast Cancer: Triple Negative	1	1
Campylobacter Infections	1	1
Cancers: All	1	1
Candida Glabrata	1	1
Cardiovascular Diseases	1	1
Cholera	1	1
Choriocarcinoma	1	1
Dental Caries	1	1
Echinococcosis	1	1
Endothelial Dysfunction	1	1
Escherichia coli Infections	1	1
Foodborne Pathogens: Prevention/Food Preservation	1	1
Glioblastoma	1	1
Gram-Negative Bacterial Infections	1	1
HIV Infections	1	1
Herpes Simplex Virus Type 1	1	1
Herpes Simplex Virus Type 2	1	1
Hydatid Cyst	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Hyperuricemia	1	1
Hypoglycemia	1	1
Klebsiella Infections	1	1
Leukemia	1	1
Liver Steatosis	1	1
Lung Cancer	1	1
Mycobacterium Avium	1	1
Mycobacterium Infections	1	1
Nose & Throat Cancer	1	1
Osteoarthritis	1	1
Periodontitis	1	1
Staphylococcus epidermidis	1	1

Name	AC	CK
Anti-Inflammatory Agents	42	92
Antioxidants	39	76
Neuroprotective Agents	23	47
Anti-Bacterial Agents	24	28
Hepatoprotective	12	21
Antiproliferative	18	20
Anti-Apoptotic	9	18
Chemoprotective Agents	8	16
Interleukin-1 beta downregulation	10	16
Apoptotic	13	15
Tumor Necrosis Factor (TNF) Alpha Inhibitor	9	15
Cardioprotective	7	14
Renoprotective	7	14
Anti-Asthmatic Agents	1	10
NF-kappaB Inhibitor	6	10
Antifungal Agents	5	9
Antimicrobial	8	8
Cyclooxygenase 2 Inhibitors	5	8
Malondialdehyde Down-regulation	4	7
Antihypertensive Agents	4	6
Antiviral Agents	5	6
Hypoglycemic Agents	4	6
Interleukin-6 Downregulation	6	6
Interleukin-4 downregulation	3	5
Photoprotective	1	5
Anti-Fibrotic	2	4
Cell cycle arrest	4	4
Immunomodulatory	2	4
Interleukin-10 upregulation	4	4
Interleukin-17 downregulation	2	4
Interleukin-5 downregulation	2	4
Nitric Oxide Inhibitor	2	4
Nrf2 activation	3	4
Antineoplastic Agents	2	3
Chemopreventive	3	3
Cholinesterase Inhibitors	2	3
Heme oxygenase-1 up-regulation	2	3
Hypolipidemic	2	3
Interferon Gamma Reducer	2	3
Interleukin-18 down-regulation	1	3
Leishmanicidal	2	3
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	3
Quorum Sensing Inhibition	3	3
Angiogenesis Inhibitors	1	2
Anti-Anxiety Agents	1	2
Anti-metastatic	2	2
Antidepressive Agents	1	2
Antiparasitic Agents	2	2
Chemosensitizer	1	2
Chemotherapeutic	2	2
Cytotoxic	1	2
Fertility Agents: Female	1	2
Gastrointestinal Agents	1	2
Gastroprotective	1	2
Interleukin-12 downregulation	1	2
Interleukin-2 Downregulation	1	2
Interleukin-8 downregulation	2	2
Phase I Detoxification Enzyme Inducer	1	2
Phase II Detoxification Enzyme Inducer	1	2
Prophylactic Agents	1	2
Radioprotective	1	2
Superoxide Dismutase Up-regulation	1	2
Vasoprotective	1	2
interleukin-13 down-regulation	1	2
Acetylcholinesterase Inhibitor	1	1
Alpha-amylase inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Autophagy Inhibitors	1	1
Bax/Bcl2 Ratio: Decrease	1	1
Bcl-2 protein down-regulation	1	1
Heat Shock Protein Down-Regulation	1	1
Interleukin-1 beta upregulation	1	1
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	1
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	1
Postaglandin PGE2 downregulation	1	1
STAT3 Inhibitor	1	1
Transforming growth factor beta (TGF-β) upregulation	1	1
Tumor Suppressor Protein p53 Upregulation	1	1
Vasodilator Agents	1	1

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Carvacrol mediates its protective effect through modulation of UVB-induced ROS.Oct 31, 2015

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Pubmed Data : J Biochem Mol Toxicol. 2015 Nov ;29(11):497-507. Epub 2010 May 21. PMID: 26768646

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Pubmed Data : Arch Physiol Biochem. 2019 Aug 9:1-9. Epub 2019 Aug 9. PMID: 31397187

Article Published Date : Aug 08, 2019

Study Type : Animal Study

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Substances : Carvacrol, Zataria multiflora

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Antioxidants, Chemoprotective Agents, Malondialdehyde Down-regulation, Renoprotective

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Both curcumin and carvacrol showed a great efficacy against hepatocellular carcinoma.Dec 31, 2014

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Pubmed Data : Can J Physiol Pharmacol. 2017 Feb 3. Epub 2017 Feb 3. PMID: 28177660

Article Published Date : Feb 02, 2017

Study Type : Animal Study

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Substances : Carvacrol

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Chemoprotective Agents, Renoprotective

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Carvacrol attenuates diabetic cardiomyopathy.Dec 31, 2018

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Pubmed Data : Front Microbiol. 2017 ;8:625. Epub 2017 Apr 21. PMID: 28484429

Article Published Date : Dec 31, 2016

Study Type : Animal Study

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Substances : Carvacrol

Diseases : Clostridium Infections, Dysbiosis

Pharmacological Actions : Gastrointestinal Agents

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Carvacrol decreases blood-brain barrier permeability post-diffuse traumatic brain injury.Sep 03, 2023

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Carvacrol reduces mercuric chloride-induced testicular toxicity.Dec 21, 2023

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Pubmed Data : Biol Trace Elem Res. 2023 Dec 22. Epub 2023 Dec 22. PMID: 38133725

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Pubmed Data : ACS Omega. 2020 Dec 8 ;5(48):31100-31114. Epub 2020 Nov 24. PMID: 33324819

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Pubmed Data : Exp Physiol. 2021 Feb 17. Epub 2021 Feb 17. PMID: 33595154

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Pubmed Data : Avicenna J Phytomed. 2020 Sep-Oct;10(5):513-522. PMID: 32995329

Article Published Date : Aug 31, 2020

Study Type : Animal Study

Additional Links

Substances : Carvacrol, Zataria multiflora

Diseases : Inflammation, Pesticide Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Problem Substances : Paraquat

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Protective effect of carvacrol against paclitaxel-induced ototoxicity. Nov 30, 2020

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Pubmed Data : Turk Arch Otorhinolaryngol. 2020 Dec ;58(4):241-248. Epub 2020 Dec 1. PMID: 33554199

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Pubmed Data : Biomed Pharmacother. 2019 Mar ;111:568-578. Epub 2018 Dec 29. PMID: 30597310

Article Published Date : Feb 28, 2019

Study Type : Animal Study

Additional Links

Substances : Carvacrol

Diseases : Diabetic Complications

Pharmacological Actions : Anti-Apoptotic, Antioxidants

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The effects of carvacrol on transient receptor potential (TRP) channels in an animal model of Parkinson's disease.Jul 14, 2023

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Pubmed Data : Neurotox Res. 2023 Jul 15. Epub 2023 Jul 15. PMID: 37452911

Article Published Date : Jul 14, 2023

Study Type : Animal Study

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Substances : Carvacrol

Diseases : Parkinson's Disease

Pharmacological Actions : Antioxidants, Neuroprotective Agents

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The protective effect of carvacrol on bevacizumab-related skin injury in rats: a biochemical and histopathological evaluation.Nov 30, 2022

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Pubmed Data : Metabolites. 2022 Dec 13 ;12(12). Epub 2022 Dec 13. PMID: 36557293

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Carvacrol and thymol isolated from O. vulgare L. exhibit good bactericidal and antibiofilm activity against S. mutans.Nov 30, 2017

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Pubmed Data : Nutr Cancer. 2017 Oct ;69(7):1075-1087. Epub 2017 Sep 5. PMID: 28872904

Article Published Date : Sep 30, 2017

Study Type : In Vitro Study

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Substances : Carvacrol

Diseases : Prostate Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

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Pubmed Data : Future Microbiol. 2018 06 1 ;13:877-888. Epub 2018 Jun 7. PMID: 29877104

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Pubmed Data : An Acad Bras Cienc. 2021 ;93(suppl 4):e20210550. Epub 2021 Nov 1. PMID: 34730626

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

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Substances : Carvacrol, Nisin, Thymol

Diseases : Salmonella Infections, Staphylococcus aureus infection

Pharmacological Actions : Antimicrobial

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Computational evaluation of major components from plant essential oils as potent inhibitors of SARS-CoV-2 spike protein.Dec 04, 2020

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Pubmed Data : J Mol Struct. 2020 Dec 5 ;1221:128823. Epub 2020 Jul 4. PMID: 32834111

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Pubmed Data : J Appl Microbiol. 2021 Feb 5. Epub 2021 Feb 5. PMID: 33544959

Article Published Date : Feb 04, 2021

Study Type : In Vitro Study

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Substances : Carvacrol, Oregano

Diseases : Cholera

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Essential Oils

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Natural compounds rosmarinic acid and carvacrol counteract aluminium-induced oxidative stress.Apr 14, 2020

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Pubmed Data : Molecules. 2021 Jan 14 ;26(2). Epub 2021 Jan 14. PMID: 33466806

This study led to the identification of carvacrol with strong binding affinity on mTOR receptor.Dec 31, 2019

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Pubmed Data : Hum Exp Toxicol. 2016 Jan 22. Epub 2016 Jan 22. PMID: 26801986

Carvacrol is a Sub of the following Topic

View the Evidence: 173 Abstracts with Carvacrol Research

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Carvacrol ameliorates haematological parameters, antioxidant biomarkers and pulmonary function in patients with sulphur mustard-induced lung disorders.Mar 24, 2018

Carvacrol reduced inflammatory cytokine and chemokine while increased anti-inflammatory cytokines in veterans exposed to mustard gas.Mar 31, 2019

Possible therapeutic effect of carvacrol on asthmatic patients.Dec 31, 2017

The combination of carvacrol and exercise could be an effective therapeutic tool for treatment of neurobehavioral deficits in Parkinson's disease patients.Jul 28, 2019

Zataria multiflora could be suggested for use against asthma.Oct 31, 2017

A study of in vitro antifungal activity of pure constituents of essentials oils against Candida-associated denture stomatitis. Carvacrol, eugenol, geraniol, linalool and terpinen-4-ol were very active in vitro against oral Candida isolates. Dec 31, 2010

Carvacrol mediates its protective effect through modulation of UVB-induced ROS.Oct 31, 2015

Anti-inflammatory activity of carvacrol protects the heart from lipopolysaccharide-induced cardiac dysfunction.Jun 30, 2023

Administration of Zataria multiflora extract and carvacrol could reduce the oxidative damage in the rat liver induced by doxorubicin.Nov 30, 2018

An extract of Zataria multiflora and carvacrol had protective effects on the renal damage induced by Adriamycin.Aug 08, 2019

Both curcumin and carvacrol showed a great efficacy against hepatocellular carcinoma.Dec 31, 2014

Carvacrol administration may have therapeutic potential after traumatic brain injury.Nov 09, 2022

Carvacrol alleviates ethanol-mediated hippocampal neuronal impairment by antioxidative and antiapoptotic effects.Dec 31, 2016

Carvacrol and pomegranate decrease methotrexate related damage and apoptotic activity in intestinal tissue.Dec 31, 2014

Carvacrol and Zataria multiflora influenced the PPARγ agonist effects on systemic inflammation and oxidative stress induced by inhaled paraquat.Jun 30, 2020

Carvacrol at high doses can reduce the harmful effects of cisplatin on the ovary and improve ovarian reserve.Feb 28, 2023

Carvacrol attenuated lipopolysaccharide-induced intestinal injury.Jul 14, 2023

Carvacrol attenuated neuroinflammation, oxidative stress and depression and anxiety like behaviors.Dec 31, 2021

Carvacrol attenuates cyclophosphamide-induced oxidative stress in rat kidney.Feb 02, 2017

Carvacrol attenuates diabetic cardiomyopathy.Dec 31, 2018

Carvacrol attenuates hippocampal neuronal death after global cerebral ischemia.Nov 25, 2018

Carvacrol can be used as a protective agent against benzo(a)pyrene-induced lung toxicity and inflammation.Dec 31, 2016

Carvacrol could potentially be used to control gut dysbiosis and reduce C. difficile infection.Dec 31, 2016

Carvacrol decreases blood-brain barrier permeability post-diffuse traumatic brain injury.Sep 03, 2023

Carvacrol decreases hypertrophy markers in in-vivo and in-vitro models of hypertrophy.Dec 31, 2018

Carvacrol enhances anti-tumor activity and mitigates cardiotoxicity of sorafenib in thioacetamide-induced hepatocellular carcinoma.Jun 30, 2023

Carvacrol exerted an anti-hyperglycemic effect in streptozotocin-induced diabetes.May 10, 2020

Carvacrol exerts anti-inflammatory, anti-oxidative stress and hepatoprotective effects against diclofenac-induced liver injury.Dec 31, 2022

Carvacrol has a hypotensive effect in normotensive rats.Oct 01, 2007

Carvacrol has significant potential as an inhibitor of memory degeneration in neurodegenerative diseases.Dec 31, 2019

Carvacrol improves blood lipid and glucose in rats with type 2 diabetes mellitus.Dec 31, 2023

Carvacrol improves vascular function in hypertensive animals.Jul 03, 2023

Carvacrol may alleviate vascular inflammation in diabetic db/db mice.Aug 31, 2020

Carvacrol may be a promising protective agent against bronchial asthma.Jan 31, 2020

Carvacrol may be a promising protective agent in λ-Cyhalothrin-induced hepatotoxicity and nephrotoxicity.Jun 30, 2023

Carvacrol mitigates vancomycin-induced nephrotoxicity.Nov 30, 2022

Carvacrol normalizes elevated liver enzymes induced by d-galactosamine-induced hepatotoxicity in rats.Dec 01, 2009

Carvacrol obtained from oregano oil significantly increases the liver regeneration rate in rats undergoing partial hepatectomy. Sep 01, 2007

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction.Dec 31, 2022

Carvacrol prevents the proconvulsant effect of LPS possibly through the inhibition of the COX-2 increased activity.Jan 11, 2018

Carvacrol promotes neuroprotection in the mouse hemiparkinsonian model.Jan 24, 2017

Carvacrol protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro models of Parkinson's disease.Jul 29, 2019

Carvacrol protects rat liver exposed to formaldehyde by regulating oxidative stress, and asprosin and subfatin hormones.Oct 31, 2023

Carvacrol provides protection for hippocampal neurons against cerebral ischemia.Aug 26, 2019

Carvacrol reduced pathological and biochemical damage, and improved kidney function by lowering the serum urea level.Nov 28, 2022

Carvacrol reduces hippocampal cell death and improves learning and memory deficits following lead-induced neurotoxicity via antioxidant activity.Apr 16, 2020

Carvacrol reduces mercuric chloride-induced testicular toxicity.Dec 21, 2023

Carvacrol suppresses learning and memory dysfunction and hippocampal damages caused by chronic cerebral hypoperfusion.Dec 31, 2019

Carvacrol suppresses the progression of liver fibrosis.Jan 31, 2019

Carvacrol targets SarA and CrtM of methicillin-resistant Staphylococcus aureus to mitigate biofilm formation and staphyloxanthin synthesis.Dec 07, 2020

Carvacrol-loaded phytosomes for enhanced wound healing.Dec 31, 2022

Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease.Jan 31, 2018

Co-administration of curcumin or carvacrol and doxorubicin for 24 days could improve the heart function and structural changes.Oct 31, 2019

Cognitive-enhancing activity of thymol and carvacrol in two rat models of dementia.May 31, 2012

Combined carvacrol and cilostazol ameliorate ethanol-induced liver fibrosis.Jan 26, 2023

Effect of carvacrol on histological analysis and expression of genes involved in an animal model of multiple sclerosis.Dec 15, 2022

Effect of treatment with carvacrol and aerobic training on cardiovascular function in spontaneously hypertensive rats.Feb 16, 2021

Effects of carvacrol on human fibroblast (WS-1) and gastric adenocarcinoma (AGS) cells in vitro and on Wistar rats in vivo.Oct 31, 2018

Eugenol and carvacrol attenuate brain D-galactose-induced aging-related oxidative alterations.Feb 18, 2022

Evaluation of the antibacterial activity and efflux pump reversal of thymol and carvacrol against Staphylococcus aureus.Apr 29, 2020

Inhibitory effects of Carvacrol on biofilm formation in Colistin Heteroresistant Acinetobacter baumannii clinical isolates.Sep 27, 2023

Neuroprotective effects of carvacrol against cadmium-induced neurotoxicity.Mar 31, 2022

Paraquat-induced systemic inflammation and increased oxidative markers in rats improved by Zataria multiflora extract and carvacrol.Aug 31, 2020

Protective effect of carvacrol against paclitaxel-induced ototoxicity. Nov 30, 2020

Protective effect of carvacrol on acetic acid-induced colitis.Nov 30, 2017

Protective effects of carvacrol against diabetes-induced reproductive damage.Nov 25, 2020

Radioprotective effects of carvacrol and/or thymol against gamma irradiation-induced acute nephropathy.Sep 12, 2023

The ameliorative effect of carvacrol on oxidative stress and germ cell apoptosis in testicular tissue of adult diabetic rats.Feb 28, 2019

The effects of carvacrol on transient receptor potential (TRP) channels in an animal model of Parkinson's disease.Jul 14, 2023

The protective effect of carvacrol on bevacizumab-related skin injury in rats: a biochemical and histopathological evaluation.Nov 30, 2022

The protective effects of thymol and carvacrol against di (2-ethylhexyl) phthalate-induced cytotoxicity in HEK-293 cells.May 05, 2022

The results indicated a preventive effect of Z. multiflora extract and its constituent, carvacrol, on tracheal responsiveness and pathological changes of the lung.Apr 30, 2015

Carvacrol

View the Evidence:
173 Abstracts with Carvacrol Research