Chaga Mushroom (Inonotus obliquus)

Name	AC	CK
Diabetes Mellitus: Type 2	7	13
Colon Cancer	9	11
Breast Cancer	6	8
Hyperglycemia	5	8
Cancers: All	6	7
Carcinoma: Non-Small-Cell Lung	6	7
Lung Cancer	6	7
Melanoma	4	7
Glioma	2	6
Oxidative Stress	5	6
Toxoplasma gondii Infection	3	6
Gastric Cancer	3	5
Inflammation	3	5
Cervical Cancer	3	4
Colitis	2	4
Diabetic Complications	2	4
Fatigue	2	4
Inflammatory Bowel Diseases	2	4
Lipid Peroxidation	2	4
Ultraviolet Radiation Induced Damage	2	4
DNA damage	2	3
Aging Skin	1	2
Alcohol Toxicity	1	2
Allergies	1	2
Alzheimer's Disease	1	2
Anaphylactic Reaction	1	2
Cat Diseases	1	2
Chemotherapy and Radiation Toxicity	1	2
Chronic Kidney Disease (CKD)	1	2
Colon Cancer: Prevention	1	2
Coronavirus Infection	2	2
Diabetes: Oxidative Stress	1	2
Diabetic Nephropathy	1	2
Endothelial Dysfunction	1	2
Food Allergies	1	2
Gastric Ulcer	1	2
Herpes Simplex Virus Type 1	2	2
High Fat Diet	1	2
Histamine: Elevated	1	2
Hydrogen Peroxide Induced Toxicity	2	2
Hyperlipidemia	1	2
Hyperuricemia	1	2
Hypoglycemia	1	2
Infertility: Male	1	2
Insulin Resistance	1	2
Liver Damage	1	2
Mental Fatigue	1	2
Myocardial Ischemia	1	2
Pancreatitis	1	2
Pancreatitis: Chronic	1	2
Prostate Cancer	2	2
Toxoplasmosis	1	2
Brain Inflammation	1	1
Breast Cancer: Triple Negative	1	1
Cancer Metastasis	1	1
Chemically-Induced Liver Damage	1	1
Chronic Lymphocytic Leukemia	1	1
Colorectal Cancer	1	1
HIV Infections	1	1
Hepatitis C	1	1
Hepatoma	1	1
Influenza	1	1
Kidney Cancer	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Lipopolysaccharide-Induced Toxicity	1	1
Lymphoma	1	1
Malignant Melanoma	1	1
Melanoma: Metastatic	1	1
Osteosarcoma	1	1
Ovarian Cancer	1	1
Upper Respiratory Infections	1	1

Name	AC	CK
Antiproliferative	21	32
Antioxidants	20	30
Apoptotic	12	19
Hypoglycemic Agents	11	18
Anti-Inflammatory Agents	10	16
Immunomodulatory	7	13
NF-kappaB Inhibitor	8	12
Chemopreventive	6	11
Antiviral Agents	7	8
Tumor Necrosis Factor (TNF) Alpha Inhibitor	4	8
Antineoplastic Agents	6	7
Malondialdehyde Down-regulation	4	7
Anti-Apoptotic	3	6
Cell cycle arrest	5	6
Hypolipidemic	3	6
Interleukin-1 beta downregulation	3	6
Nrf2 activation	3	6
Bcl-2 protein down-regulation	1	5
Chemotherapeutic	4	5
Cytotoxic	5	5
Hepatoprotective	4	5
Immunostimulatory	3	5
Cyclooxygenase 2 Inhibitors	3	4
Gastrointestinal Agents	2	4
Interleukin-4 downregulation	2	4
Neuroprotective Agents	3	4
Renoprotective	2	4
Alpha-glucosidase inhibitor	3	3
Anti-metastatic	3	3
Genoprotective	2	3
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	3
P21 Activation	2	3
Pancreato Protective Agents	2	3
Superoxide Dismutase Up-regulation	2	3
Tumor Suppressor Protein p53 Upregulation	3	3
Analgesics	1	2
Anti-Allergic Agents	1	2
Anti-Ulcer Agents	1	2
Antinoceceptive	1	2
Antiparasitic Agents	1	2
Cardioprotective	1	2
Chemoprotective Agents	1	2
Cyclin D1 Down-Regulation	1	2
Cytoprotective	1	2
DNA Repair Up-regulation	1	2
Gastroprotective	1	2
Heme oxygenase-1 up-regulation	1	2
Interferon Gamma Reducer	1	2
Interleukin-10 upregulation	1	2
Interleukin-2 Downregulation	1	2
Interleukin-6 Downregulation	1	2
Lactate Dehydrogenase A Inhibitor	1	2
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	2
Nitric Oxide Inhibitor	1	2
Photoprotective	1	2
Radioprotective	1	2
Uricosuric Agents	1	2
Alpha-amylase inhibitor	1	1
Anti-HIV Agents	1	1
Anti-Infective Agents	1	1
Autophagy Up-regulation	1	1
Chemosensitizer	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1

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Chaga mushroom extract can inhibit the proliferation of tumor cells.Dec 31, 2013

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Pubmed Data : Int J Med Mushrooms. 2014 ;16(1):29-36. PMID: 24940902

Article Published Date : Dec 31, 2013

Study Type : Human In Vitro

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Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Glioma

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation

Additional Keywords : Plant Extracts

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Lipid-lowering effects of Inonotus obliquus polysaccharide.Dec 11, 2021

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Pubmed Data : Foods. 2021 Dec 12 ;10(12). Epub 2021 Dec 12. PMID: 34945636

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Pubmed Data : Int J Biol Macromol. 2022 Jun 14. Epub 2022 Jun 14. PMID: 35714869

Article Published Date : Jun 13, 2022

Study Type : Animal Study

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Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Gastroprotective

Additional Keywords : Polysaccharides

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A water extract of Chaga mushroom is a very potent immune modulator that recovers the bone marrow system damaged by chemotherapy.Aug 31, 2005

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Pubmed Data : Molecules. 2014 ;19(9):14383-95. Epub 2014 Sep 12. PMID: 25221864

Article Published Date : Dec 31, 2013

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Antrodia camphorata, Chaga Mushroom (Inonotus obliquus), Phellinus Linteus, Reishi Mushroom

Diseases : Melanoma

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Cyclin D1 Down-Regulation, P21 Activation

Additional Keywords : Plant Extracts, Superiority of Natural Substances versus Drugs

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Chaga mushroom and its compounds could be used as natural anticancer ingredients.May 31, 2010

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Pubmed Data : Nutr Res Pract. 2010 Jun ;4(3):177-82. Epub 2010 Jun 29. PMID: 20607061

Article Published Date : May 31, 2010

Study Type : Animal Study, In Vitro Study

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Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Breast Cancer, Carcinoma: Non-Small-Cell Lung, Cervical Cancer, Gastric Cancer

Pharmacological Actions : Antiproliferative

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Chaga mushroom extract significantly reduced the total IgE levels in mice and slightly affected the production of IgG1.Mar 31, 2013

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Pubmed Data : Int Immunopharmacol. 2013 Apr ;15(4):666-70. Epub 2013 Mar 25. PMID: 23535020

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Pubmed Data : AMB Express. 2017 Dec ;7(1):39. Epub 2017 Feb 14. PMID: 28197985

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Pubmed Data : Front Endocrinol (Lausanne). 2022 ;13:1103972. Epub 2023 Jan 6. PMID: 36686454

Article Published Date : Dec 31, 2021

Study Type : Animal Study

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Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents

Additional Keywords : Plant Extracts

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Phelligridin D from Inonotus obliquus attenuates oxidative stress and accumulation.Aug 31, 2021

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Pubmed Data : J Nat Med. 2021 Sep ;75(4):1021-1029. Epub 2021 May 29. PMID: 34052991

Article Published Date : Aug 31, 2021

Study Type : Animal Study

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Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Diabetes: Oxidative Stress, Diabetic Nephropathy

Pharmacological Actions : Antioxidants, Transforming growth factor beta (TGF-β) inhibitor

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Polysaccharide derived from Inonotus obliquus inhibits lipopolysaccharide-induced acute endometritis.Dec 31, 2021

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Pubmed Data : Heliyon. 2021 Feb ;7(2):e06003. Epub 2021 Feb 4. PMID: 33598573

Article Published Date : Jan 31, 2021

Study Type : Animal Study

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Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : DNA damage, Ultraviolet Radiation Induced Damage

Pharmacological Actions : DNA Repair Up-regulation, Genoprotective, Photoprotective

Additional Keywords : Polysaccharides

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These results provide valuable evidences to support the use of I. obliquus as a hypoglycemic functional food.Dec 31, 2016

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Pubmed Data : PLoS One. 2017 ;12(6):e0180476. Epub 2017 Jun 29. PMID: 28662169

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Pubmed Data : J Food Biochem. 2022 03 ;46(3):e13932. Epub 2021 Sep 15. PMID: 34528276

Article Published Date : Dec 31, 2021

Study Type : Animal Study

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Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Hyperuricemia, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Uricosuric Agents

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Pubmed Data : Int J Med Mushrooms. 2011 ;13(2):131-43. PMID: 22135889

Article Published Date : Dec 31, 2010

Study Type : In Vitro Study

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Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Carcinoma: Non-Small-Cell Lung, Colon Cancer, Glioma

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

Additional Keywords : Plant Extracts

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Chaga mushroom extract induces autophagy via the AMPK-mTOR signaling pathway in breast cancer cells.Mar 29, 2021

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Pubmed Data : J Ethnopharmacol. 2021 Mar 30 ;274:114081. Epub 2021 Mar 30. PMID: 33798660

Article Published Date : Mar 29, 2021

Study Type : In Vitro Study

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Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Breast Cancer

Pharmacological Actions : Autophagy Up-regulation, Chemotherapeutic

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Chaga mushroom polysaccharides possess multiple radical scavenging activities in a dose-dependent manner.Dec 31, 2011

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Pubmed Data : Int J Mol Sci. 2012 ;13(7):9194-206. Epub 2012 Jul 23. PMID: 22942760

Article Published Date : Dec 31, 2011

Study Type : In Vitro Study

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Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords : Dose Response

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Compounds isolated from Inonotus obliquus had hepatoprotective effects and exhibiting selective cytotoxicities.Jan 23, 2014

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Pubmed Data : J Nat Prod. 2014 Jan 24 ;77(1):35-41. Epub 2013 Dec 20. PMID: 24359303

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Pubmed Data : J Biosci Bioeng. 2009 Jan ;107(1):42-8. PMID: 19147108

Article Published Date : Dec 31, 2008

Study Type : In Vitro Study

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Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Colon Cancer

Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

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Extracts of chaga mushroom possessed anti-herpetic activities in vitro. Feb 28, 2014

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Pubmed Data : Vopr Virusol. 2014 Mar-Apr;59(2):45-8. PMID: 25069286

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Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:2245496. Epub 2021 Dec 29. PMID: 35003292

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Toxoplasma gondii Infection

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Polysaccharides

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Inonotsuoxide B suppresses hepatic stellate cell activation and proliferation.May 31, 2022

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Pubmed Data : Molecules. 2013 ;18(8):9293-304. Epub 2013 Aug 2. PMID: 23917116

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Pubmed Data : Int J Biol Sci. 2023 ;19(15):4898-4914. Epub 2023 Sep 11. PMID: 37781506

Pubmed Data : Phytomedicine. 2019 Jul ;60:152957. Epub 2019 May 13. PMID: 31128995

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Pubmed Data : Prep Biochem Biotechnol. 2021 Jan 13:1-8. Epub 2021 Jan 13. PMID: 33439073

Article Published Date : Jan 12, 2021

Study Type : In Vitro Study

Additional Links

Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants

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Phenolic compounds from chaga mushrooms have cytotoxicity against cancer cells. May 31, 2009

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Pubmed Data : J Med Food. 2009 Jun ;12(3):501-7. PMID: 19627197

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Pubmed Data : Nutrients. 2020 Aug 25 ;12(9). Epub 2020 Aug 25. PMID: 32854262

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Pubmed Data : Biomed Khim. 2016 May ;62(4):369-75. PMID: 27562990

Article Published Date : Apr 30, 2016

Study Type : Review

Additional Links

Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Cancers: All

Pharmacological Actions : Antiproliferative

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Water extract of the Chaga medicinal mushroom, Inonotus obliquus inhibits SARS-CoV-2 replication.Dec 31, 2021

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Pubmed Data : Int J Med Mushrooms. 2022 ;24(2):23-30. PMID: 35446519

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

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Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

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View the Evidence: 123 Abstracts with Chaga Mushroom (Inonotus obliquus) Research

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Chaga mushroom extract can inhibit the proliferation of tumor cells.Dec 31, 2013

Lipid-lowering effects of Inonotus obliquus polysaccharide.Dec 11, 2021

Neuroprotective effects of a new triterpenoid from edible mushroom on oxidative stress and apoptosis.Nov 27, 2022

Protective effects of chaga medicinal mushroom, Inonotus obliquus extract on β-amyloid-induced neurotoxicity.Dec 31, 2020

A fraction from I. obliquus showed significant antihyperglycaemic and antilipidperoxidative effects in alloxan-induced diabetic mice.Jan 29, 2010

A polysaccharide from Inonotus obliquus ameliorates intestinal barrier dysfunction in mice with type 2 diabetes mellitus.Jun 13, 2022

A water extract of Chaga mushroom is a very potent immune modulator that recovers the bone marrow system damaged by chemotherapy.Aug 31, 2005

A water-soluble polysaccharide from chaga mushroom had potential as a natural antitumor agent with immunomodulatory activity.Sep 30, 2012

An aqueous extract of I. obliquus might be a useful supplement in the setting of inflammatory bowel disease.Sep 27, 2012

Anti-diabetic eﬀects of Inonotus obliquus extract.Dec 19, 2022

Antiviral activity of basidial fungus Inonotus obliquus aqueous extract against SARS-CоV-2 virus.May 17, 2023

Approximately 67% of the initial number of mice survived with no tumor incidence based on macroscopic examination.May 29, 2006

Betulin may be one of the anti-hyperuricemia bioactives in I. obliquus.Oct 17, 2018

CARI III exerted anti-cancer activity that is comparable to doxorubicin against melanoma in vivo, as well as in vitro.Dec 31, 2013

Chaga mushroom and its compounds could be used as natural anticancer ingredients.May 31, 2010

Chaga mushroom extract significantly reduced the total IgE levels in mice and slightly affected the production of IgG1.Mar 31, 2013

Chaga mushroom modulates immune responses through secretion of Th1/Th2 cytokines and regulates antigen-specific antibody production.Oct 10, 2011

Chaga mushroom possesses significant antihyperglycaemic, antilipidperoxidative and antioxidant effects in alloxan-induced diabetic mice.Mar 31, 2010

Chaga mushroom supplements as nutraceuticals have a positive effect on lipid transport and exercise performance.Nov 24, 2022

Continuous intake of the I. obliquus extract could suppress tumor progression.Apr 30, 2016

Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis.Dec 31, 2020

Ergosterol peroxide down-regulated β-catenin signaling, which exerted anti-proliferative and pro-apoptotic activities in CRC cells.Sep 14, 2015

Evaluation of toxicity and efficacy of inotodiol as an anti-inflammatory agent.Jul 22, 2022

I. obliquus can prevent the aging process by attenuating oxidative stress in a model of stress-induced premature senescence.Apr 30, 2011

I. obliquus extract ameliorated insulin resistance and lipid metabolism disorders.Jun 11, 2021

Immunomodulatory effects of Inonotus obliquus polysaccharide on splenic lymphocytes infected with Toxoplasma gondii.Jan 31, 2022

Inonotus obliquus and its bioactive compounds alleviate non-alcoholic fatty liver disease.Apr 14, 2022

Inonotus obliquus aqueous extract prevents histopathological alterations in liver induced by environmental toxicant Microcystin.Dec 31, 2021

Inonotus obliquus attenuates histamine-induced microvascular inflammation. Dec 31, 2018

Inonotus obliquus ethanol crude extract could provide renal protection in diabetes nephropathy.Feb 22, 2023

Inonotus obliquus extract alleviates myocardial ischemia/reperfusion injury by suppressing endoplasmic reticulum stress.Dec 31, 2020

Inonotus obliquus polysaccharide ameliorates dextran sulphate sodium induced colitis.Nov 30, 2019

Inonotus obliquus polysaccharide ameliorates impaired reproductive function caused by toxoplasma gondii infection.May 14, 2020

Inonotus obliquus polysaccharide ameliorates serum profiling in STZ-induced diabetic mice model.Dec 16, 2021

Inonotus obliquus polysaccharide has strong activity for ameliorating chronic pancreatitis and a beneficial effect on gut microbiota.Nov 30, 2017

Inonotus obliquus polysaccharide helped to alleviate pancreatic acinar atrophy and weight loss in mice with chronic pancreatitis.May 31, 2016

Inonotus obliquus polysaccharide may be a therapeutic drug candidate for colitis-associated cancer.Dec 31, 2019

Inonotus obliquus polysaccharide protects against adverse pregnancy caused by Toxoplasma gondii infection.Nov 10, 2019

Inonotus obliquus polysaccharides had significant protective effect on microwave radiation induced testicular injury.Jun 30, 2014

Inonotus obliquus polysaccharides may be a potential broad-spectrum antiviral drug against feline viruses.Jan 31, 2017

Inonotus obliquus polysaccharides protect against Alzheimer's disease.Mar 12, 2019

Inonotus obliquuspolysaccharides might be a potential anti-fatigue pharmacological agent.Jul 31, 2015

Inotodiol can be a preventive approach in managing dietary chronic conditions like diabetic-breast cancer.Feb 28, 2018

Low-molecular-weight polysaccharides of Inonotus obliquus may be advantageous to control the progression of CKD.Dec 31, 2015

Methanol extract of Inonotus obliquus improves type 2 diabetes mellitus through modifying intestinal flora.Dec 31, 2021

Phelligridin D from Inonotus obliquus attenuates oxidative stress and accumulation.Aug 31, 2021

Polysaccharide derived from Inonotus obliquus inhibits lipopolysaccharide-induced acute endometritis.Dec 31, 2021

Polysaccharide from fermented mycelium of Inonotus obliquus attenuates the ulcerative colitis and adjusts the gut microbiota in mice.Mar 31, 2023

Polysaccharides from Inonotus obliquus may provide a valuable therapeutic option against diabetes.Dec 31, 2013

Polysaccharides from Inonotus obliquus might be a good candidate for the functional food or pharmaceuticals in the treatment of T2DM.Sep 30, 2017

Polysaccharides from Inonotus obliquus might be a promising functional food or drug candidate for diabetes treatment.Sep 22, 2017

Polysaccharides isolated from fruiting body of Inonotus obliquus had potent immunostimulating activity in vitro and in vivo. Jan 31, 2011

Renal protective effects of Inonotus obliquus on high-fat diet/streptozotocin-induced diabetic kidney disease.Dec 31, 2020

Spatial structure and anti-fatigue of polysaccharide from Inonotus obliquus.May 14, 2020

Study on the hypolipidemic effect of Inonotus obliquus polysaccharide in hyperlipidemia.Dec 31, 2022

The difference of regulatory effect of two Inonotus obliquus extracts on high-fat diet mice in relation to the fatty acid elongation function of gut microbiota.Dec 31, 2020

The mast cell stabilizing activity of Chaga mushroom critical for its therapeutic effect on food allergy is derived from inotodiol.Dec 31, 2017

The polysaccharide from Inonotus obliquus protects mice from Toxoplasma gondii-induced liver injury.Mar 14, 2019

The study delineated the efficacy of chaga polysaccharides in mitigating UV-induced DNA damage in zebrafish.Jan 31, 2021

These results provide valuable evidences to support the use of I. obliquus as a hypoglycemic functional food.Dec 31, 2016

This confirmed the traditional uses of I. obliquus in the treatment of gastric ulceration.Dec 31, 2018

This study indicates that a methanol extract from Inonotus obliquus has anti-inflammatory and anti-nociceptive properties.Oct 02, 2005

Trametenolic acid ameliorates the progression of diabetic nephropathy.Dec 31, 2021

Triterpenoid acids from medicinal mushroom Inonotus obliquus (Chaga) alleviate hyperuricemia and inflammation.Dec 31, 2021

Water-soluble melanin complex of I. obliquus exerts antihyperglycemic and beneficial lipid-metabolic effects.Aug 31, 2014

A hot-water extract of I. obliquus had anti-tumor activities. Feb 28, 2015

An ethanol extract of chaga mushroom inhibits the cell proliferation and induced cell cycle arrest in a dose dependent manner.Mar 31, 2015

An extract from a Chaga mushroom prevents herpes simplex virus entry through inhibition of viral-induced membrane fusion.Dec 31, 2012

Anti-inflammatory character of Phelligridin D modulates periodontal regeneration in lipopolysaccharide-induced human periodontal ligament cells.Sep 30, 2018

Anti-malarial activity in a Chinese herbal supplement containing Inonotus obliquus and Panax notoginseng.Mar 31, 2022

Anti-neuroinflammatory polyoxygenated lanostanoids from Chaga mushroom Inonotus obliquus.Jan 08, 2021

Antiaging effect of inotodiol on oxidative stress in human dermal fibroblasts.Aug 31, 2022

Chaga Mushroom (Inonotus obliquus)

View the Evidence:
123 Abstracts with Chaga Mushroom (Inonotus obliquus) Research