Cinnamaldehyde

Name	AC	CK
Oxidative Stress	4	10
Diabetes Mellitus: Type 2	3	6
Obesity	3	6
Alzheimer's Disease	3	5
Myocardial Fibrosis	1	5
Pseudomonas aeruginosa	5	5
Rheumatoid Arthritis	1	5
Carcinoma: Non-Small-Cell Lung	3	4
Diabetes Mellitus: Type 1	2	4
Escherichia coli Infections	4	4
High Fat Diet	2	4
Coronavirus Infection	3	3
Diabetic Complications	2	3
Infection: Antibiotic Resistant	3	3
Lipopolysaccharide-Induced Toxicity	2	3
Melanoma	2	3
Salmonella Infections	3	3
Aging	1	2
Allergic Rhinitis	1	2
Alloxan toxicity	1	2
Aluminum Toxicity	1	2
Animal Diseases: Infectious	1	2
Anxiety	1	2
Arthritis	1	2
Candida Albicans	2	2
Candidiasis	1	2
Cardiomyopathy	1	2
Cataract	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Colon Cancer: Prevention	1	2
Colorectal Cancer	1	2
Diabetes: Cardiovascular Illness	1	2
Diabetes: Cataract	1	2
Diabetes: Glycation/A1C	1	2
Diabetes: Hypertension	1	2
Diabetic Nephropathy	1	2
Endothelial Dysfunction	1	2
Endotoxemia	1	2
Foodborne Pathogens: Prevention/Food Preservation	2	2
Gestational Diabetes	1	2
High Fructose Diet	1	2
Hypercholesterolemia	1	2
Hypertension	1	2
Inflammation	1	2
Insulin Resistance	1	2
Lung Cancer: Prevention	1	2
Lung Injury: Acute	1	2
Mycobacterium Tuberculosis	1	2
Oral Cancer	2	2
Oral Candidosis	1	2
Overweight	1	2
Sciatic Nerve Crush Injury	1	2
Staphylococcus aureus infection	1	2
Subarachnoid hemorrhage	1	2
Urinary Tract Infections	2	2
Aspergillosis	1	1
Bacterial Infections	1	1
Bacterial Infections: Resistance/Biofilm Formation	1	1
Campylobacter Infections	1	1
Candidiasis: Vulvovaginal	1	1
Clostridium Infections	1	1
Diabetic Neuropathy	1	1
Dysmenorrhea	1	1
Gastrointestinal Inflammation	1	1
Helicobacter Pylori Infection	1	1
Infertility: Female	1	1
Intoxication	1	1
Legionella pneumophila	1	1
Legionellosis	1	1
Legionnaires' disease	1	1
Leishmaniasis	1	1
Listeria Infections	1	1
Liver Cancer	1	1
Lyme Disease	1	1
Progesterone: Low	1	1
Prostate Cancer	1	1
Skin Cancer	1	1
Squamous cell carcinoma	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Staphylococcus epidermidis	1	1
Steptococcus Mutans Infections	1	1
Streptococcus pyogenes	1	1
Ultraviolet Radiation Induced Damage	1	1
Wound Healing	1	1

Name	AC	CK
Anti-Inflammatory Agents	13	25
Antioxidants	10	20
Anti-Bacterial Agents	12	14
Neuroprotective Agents	6	10
Nrf2 activation	6	10
Apoptotic	7	9
Tumor Necrosis Factor (TNF) Alpha Inhibitor	4	9
Interleukin-6 Downregulation	3	7
NF-kappaB Inhibitor	4	6
Anti-Fibrotic	1	5
Antifungal Agents	4	5
Chemopreventive	3	5
Hypoglycemic Agents	3	5
Interleukin-1 beta downregulation	3	5
Anticarcinogenic Agents	2	4
Insulin Sensitizers	2	4
Malondialdehyde Down-regulation	2	4
Antimicrobial	3	3
Adiponectin Down-Regulation	1	2
Anti-Adipogenic	1	2
Anti-Allergic Agents	1	2
Anti-Anxiety Agents	1	2
Anti-metastatic	2	2
Anticholesteremic Agents	1	2
Antihypertensive Agents	1	2
Antiviral Agents	2	2
Cell cycle arrest	2	2
Chemoprotective Agents	1	2
Chemotherapeutic	1	2
Heme oxygenase-1 inducer	2	2
Heme oxygenase-1 up-regulation	1	2
Immunomodulatory	1	2
Vasoprotective	1	2
Wnt/β-catenin signaling pathway modulation	1	2
Antiproliferative	1	1
Autophagy Inhibitors	1	1
Cytotoxic	1	1
Glutathione Upregulation	1	1
Hypolipidemic	1	1
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	1
Immunostimulatory	1	1
Interleukin-8 downregulation	1	1
Leishmanicidal	1	1
Phase II Detoxification Enzyme Inducer	1	1
Photoprotective	1	1
Regenerative	1	1
Wnt/β-catenin pathway down-regulation	1	1

Pharmacological Actions : Anti-Bacterial Agents

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Anxiolytic-like effect of inhaled cinnamon essential oil and its main component cinnamaldehyde.Nov 17, 2022

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Pubmed Data : Molecules. 2022 Nov 18 ;27(22). Epub 2022 Nov 18. PMID: 36432096

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Pubmed Data : Inflammation. 2020 Oct ;43(5):1729-1741. PMID: 32851511

Article Published Date : Sep 30, 2020

Study Type : Animal Study

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Substances : Cinnamaldehyde

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-metastatic, Antiproliferative

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Cinnamaldehyde co-administration prevented HFD-induced body weight gain, and decreased fasting-induced hyperphagia.Feb 29, 2016

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Pubmed Data : Biofactors. 2016 Mar-Apr;42(2):201-11. Epub 2016 Feb 19. PMID: 26893251

Article Published Date : Feb 29, 2016

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Pubmed Data : Cancers (Basel). 2020 Jan 29 ;12(2). Epub 2020 Jan 29. PMID: 32013122

Article Published Date : Jan 28, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cinnamaldehyde

Diseases : Melanoma

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

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Cinnamaldehyde enhances apoptotic effect of oxaliplatin and reverses epithelial-mesenchymal transition and stemnness in hypoxic colorectal cancer cells.Jul 11, 2019

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Pubmed Data : Exp Cell Res. 2019 Jul 12:111500. Epub 2019 Jul 12. PMID: 31306656

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Pubmed Data : Immunopharmacol Immunotoxicol. 2017 Oct ;39(5):296-304. Epub 2017 Aug 1. PMID: 28762847

Article Published Date : Sep 30, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cinnamaldehyde

Diseases : Endotoxemia

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation

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Cinnamaldehyde improves metabolic functions in streptozotocin-induced diabetic mice by regulating gut microbiota.Dec 31, 2020

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The phytonutrient cinnamaldehyde limits intestinal inflammation and enteric parasite infection.Oct 12, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Anticancer Agents Med Chem. 2021 Jul 26. Epub 2021 Jul 26. PMID: 34315398

Article Published Date : Jul 25, 2021

Study Type : In Vitro Study

Additional Links

Substances : Cinnamaldehyde

Diseases : Bladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

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Antimicrobial activity of cinnamaldehyde on Streptococcus mutans biofilms.Dec 31, 2018

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Pubmed Data : Front Microbiol. 2019 ;10:2241. Epub 2019 Sep 25. PMID: 31608045

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Acta Pharmacol Sin. 2021 May 12. Epub 2021 May 12. PMID: 33980998

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Cinnamomum cassia essential oil and cinnamaldehyde may possess anti-oral cancer activity in HSC-3 cells.Jan 31, 2017

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Pubmed Data : Environ Toxicol. 2017 Feb ;32(2):456-468. Epub 2016 Feb 25. PMID: 26919256

Article Published Date : Jan 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Cinnamaldehyde, Cinnamon

Diseases : Oral Cancer

Pharmacological Actions : Apoptotic, Cell cycle arrest

Additional Keywords : Essential Oils

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Cinnamomum verum J. Presl and its active compounds exhibited in vitro anticancer effects on oral squamous cell carcinoma.Aug 31, 2020

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Pubmed Data : J Contemp Dent Pract. 2020 Sep 1 ;21(9):1027-1033. Epub 2020 Sep 1. PMID: 33568591

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2016 Jun 1 ;16:158. Epub 2016 Jun 1. PMID: 27245046

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Pubmed Data : Lett Appl Microbiol. 2020 May 1. Epub 2020 May 1. PMID: 32357268

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Pubmed Data : Life Sci. 2010 Jun 5;86(23-24):894-8. Epub 2010 Apr 25. PMID: 20423713

Article Published Date : Jun 05, 2010

Study Type : In Vitro Study

Additional Links

Substances : Cinnamaldehyde, DHEA (Dehydroepiandrosterone), Progesterone

Diseases : Dysmenorrhea, Infertility: Female, Progesterone: Low

Additional Keywords : Science Confirms Tradition

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These findings could provide a better understanding of the mechanism by which cinnamaldehyde inhibits L. monocytogenes biofilm formation.Jun 14, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Microbiol Spectr. 2023 Jun 15 ;11(3):e0030023. Epub 2023 May 4. PMID: 37140461

Article Published Date : Jun 14, 2023

View the Evidence: 116 Abstracts with Cinnamaldehyde Research

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Cinnamaldehyde and eugenol were found to exert potent anti-inflammatory and anti-oxidant effects on the PBMC culture of rheumatoid arthritis patients.Jun 04, 2019

Cinnamaldehyde may be able to slow down the progression of cardiac fibrosis.Mar 20, 2017

Cinnamaldehyde decreases the invasion and u-PA expression of osteosarcoma by down-regulating the FAK signalling pathway.Jun 19, 2022

Antimycobacterial activity of cinnamaldehyde in a Mycobacterium tuberculosis(H37Ra) model.Sep 17, 2018

Anxiolytic-like effect of inhaled cinnamon essential oil and its main component cinnamaldehyde.Nov 17, 2022

Berberine and cinnamaldehyde together prevent lung carcinogenesis.Sep 28, 2017

Cinnamaldehyde ameliorates collagen-induced arthritis in rats.Feb 05, 2020

Cinnamaldehyde ameliorates high-glucose-induced oxidative stress and cardiomyocyte injury.Jun 30, 2019

Cinnamaldehyde and berberine have greater anti-diabetic efficacy than metformin. Nov 05, 2008

Cinnamaldehyde and hesperetin attenuate TNBS-induced ulcerative colitis.Apr 30, 2021

Cinnamaldehyde attenuates cataractogenesis via restoration of hypertension and oxidative stress.May 31, 2016

Cinnamaldehyde attenuates the progression of rheumatoid arthritis.Sep 30, 2020

Cinnamaldehyde co-administration prevented HFD-induced body weight gain, and decreased fasting-induced hyperphagia.Feb 29, 2016

Cinnamaldehyde could play a role in subarachnoid hemorrhage treatment.Aug 22, 2019

Cinnamaldehyde enhanced functional recovery after sciatic nerve crush injury.May 10, 2020

Cinnamaldehyde enhances antimelanoma activity through covalently binding ENO1 and exhibits a promoting effect with dacarbazine.Jan 28, 2020

Cinnamaldehyde enhances apoptotic effect of oxaliplatin and reverses epithelial-mesenchymal transition and stemnness in hypoxic colorectal cancer cells.Jul 11, 2019

Cinnamaldehyde exerts vasculoprotective effects in hypercholestrolemic rabbits.Oct 31, 2018

Cinnamaldehyde exhibits anti-adipogenic properties.Apr 27, 2011

Cinnamaldehyde exhibits therapeutic potency against obesity by inducing the browning of white adipose tissue.Jul 17, 2017

Cinnamaldehyde has a protective effect in the endotoxin poisoned mice through the inhibition of NLRP3 inflammasome activation.Sep 30, 2017

Cinnamaldehyde improves metabolic functions in streptozotocin-induced diabetic mice by regulating gut microbiota.Dec 31, 2020

Cinnamaldehyde increases the survival of mice submitted to sepsis.Mar 08, 2022

Cinnamaldehyde induces cell apoptosis in non-small cell lung cancer.Nov 24, 2017

Cinnamaldehyde is an effective anti-inflammatory agent for treatment of allergic rhinitis.Apr 30, 2016

Cinnamaldehyde may represent an alternative therapy to control S. aureus-induced bacterial infections without promoting an adaptive phenotype.Dec 31, 2015

Cinnamaldehyde microcapsules enhance bioavailability and regulate intestinal flora in mice.Oct 29, 2022

Cinnamaldehyde mitigates atherosclerosis induced by high-fat diet.Dec 31, 2021

Cinnamaldehyde potentially attenuates gestational hyperglycemia in rats.Jan 12, 2017

Cinnamaldehyde promotes the intestinal barrier functions and reshapes gut microbiome in early weaned rats.Dec 31, 2020

Cinnamaldehyde protected endothelial dysfunction under high glucose conditions and this effect was mediated by Nrf2 activation and the up-regulation of downstream target proteins.Dec 31, 2014

Cinnamaldehyde protects against ligature-induced periodontitis.Jul 31, 2022

Cinnamaldehyde protects from the hypertension associated with type 1 and type 2 diabetes.Aug 05, 2011

Cinnamaldehyde suppresses age-related inflammatory NF-kappaB activation.Oct 01, 2007

Cinnamaldehyde suppresses AOM/DSS-induced inflammatory colon carcinogenesis by modulation of molecular markers of colorectal carcinogenesis.Apr 30, 2015

Cinnamaldehyde suppresses NLRP3 derived IL-1β via activating succinate/HIF-1 in rheumatoid arthritis.Jun 30, 2020

Cinnamaldehyde treatment during adolescence improves white and brown adipose tissue metabolism in a male rat model of early obesity.Mar 20, 2022

Cinnamaldehyde-based self-nanoemulsion accelerates wound healing.Aug 15, 2022

Cinnamic acid and cinnamaldehyde revealed the promising protective effects on cisplatin induced splenotoxicity in ratsJun 23, 2015

Cinnamon contains cinnamaldehyde which confers dose-dependent, significant protection against alloxan-induced renal damage and hyperglycemica. Oct 29, 2009

Cinnamon oil (cinnamaldehyde) has therapeutic activity against oral Candida infection. Jan 01, 2010

Cinnamon reduces glucose, A1C and significantly improves blood lipid profiles.Jan 01, 2007

Dietary cinnamaldehyde enhances acquisition of specific antibodies following helminth infection in pigs.Jun 30, 2017

Neuro-amelioration of cinnamaldehyde in aluminum-induced Alzheimer's disease rat model.Aug 27, 2019

Neuroprotective effect of cinnamaldehyde on secondary brain injury after traumatic brain injury.Aug 31, 2021

Oral sub-chronic cinnamaldehyde administration has the capability to prevent memory retrieval deficit induced by cholinergic blockade.Jan 31, 2020

Supplementation of cinnamaldehyde might be a preventive strategy to alleviate liver injury caused by Salmonella typhimurium infection.Apr 15, 2021

The phytonutrient cinnamaldehyde limits intestinal inflammation and enteric parasite infection.Oct 12, 2021

The results demonstrated that the administration of cinnamaldehyde produced anxiolytic effects.Apr 30, 2019

These finding suggests that Cinnamaldehyde is a potential anti-inflammatory agent in treatment the acute lung injury.Aug 29, 2017

A compound in cinammon has anti-biofilm against uropathogenic Escherichia coli. Jul 01, 2010

A review of cinnamaldehyde and its derivatives as antibacterial agents.Oct 31, 2019

A review of in vitro and vivo antihepatocarcinogenic effects of natural compounds. Jul 31, 2011

Antibacterial and anti-biofilm activities of cinnamaldehyde against S. epidermidis.Dec 31, 2018

Antibacterial and antibiofilm Activities of Cinnamomum Sp. essential oil and cinnamaldehyde: antimicrobial activities.Dec 31, 2017

Anticancer effects of cinnamaldehyde through Inhibition of ErbB2/HSF1/LDHA pathway in 5637 cell line of bladder cancer.Jul 25, 2021

Antimicrobial activity of cinnamaldehyde on Streptococcus mutans biofilms.Dec 31, 2018

Antioxidant cinnamaldehyde attenuates UVB-induced photoaging.Nov 30, 2019

Carvacrol, cinnamaldehyde, thymol, or oregano oil inhibit Clostridum prefringens in beef.Jul 01, 2006

Cinamaldehyde exhibits inhibitory activity against Legionella pneumophila.Jan 01, 2008

Cinnamaldehyde acts as an oxidative stress agent against E. coli.Mar 03, 2016

Cinnamaldehyde ameliorated LPS-induced cardiac dysfunction.Nov 30, 2016

Cinnamaldehyde and curcumin prime Akt2 for insulin-stimulated activation.Aug 11, 2022

Cinnamaldehyde and eugenol may be suitable for regenerative medicine and tissue engineering when used at low concentrations.Oct 31, 2016

Cinnamaldehyde and eugenol protect against LPS-stimulated oxidative stress and inflammation in Raw 264.7 cells.Oct 21, 2021

Cinnamaldehyde as a promising dietary phytochemical against metabolic syndrome.Jul 24, 2023

Cinnamaldehyde decreased angiogenesis and metastasis in tumor cells by inhibiting HIF-1α protein accumulation.Mar 09, 2019

Cinnamaldehyde disrupts biofilm formation and swarming motility of Pseudomonas aeruginosa.Aug 31, 2018

Cinnamaldehyde downregulation of Sept9 inhibits glioma progression.Dec 31, 2021

Cinnamaldehyde enhances detoxification by increasing phase 2 enzyme expression. May 11, 2011

Cinnamaldehyde for the treatment of microbial infections: evidence obtained from experimental models. Oct 04, 2022

Cinnamaldehyde had antibiofilm activity.Sep 29, 2017

Cinnamaldehyde

View the Evidence:
116 Abstracts with Cinnamaldehyde Research