Citrulline

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30 Diseases Researched for Citrulline
NameACCKFocus
Hypertension551Locked
Heart Failure330Locked
Athletic Performance524Locked
Athletic Performance: Recovery 321Locked
Arterial Hardening: Elasticity220Locked
Muscle Soreness220Locked
Muscle Soreness: Exercise-Induced220Locked
Obesity220Locked
Anemia: Sickle Cell 110Locked
Endothelial Dysfunction110Locked
Erectile Dysfunction110Locked
Left Ventricular Dysfunction110Locked
Muscle Damage110Locked
Muscle Damage: Exercise-Induced110Locked
Sperm Count: Low110Locked
Nonalcoholic fatty liver disease (NAFLD)24Locked
Aging12Locked
Cognitive Decline/Dysfunction12Locked
Endotoxemia12Locked
Hypertension: Pulmonary12Locked
Hypoxia12Locked
Inflammation12Locked
Insulin Resistance12Locked
Klebsiella Infections12Locked
Metabolic Syndrome X12Locked
Mitochondrial Dysfunction 12Locked
Sarcopenia12Locked
Sepsis12Locked
Diabetes Mellitus: Type 111Locked
Diabetes Mellitus: Type 211Locked
12 Pharmacological Actions Researched for Citrulline
NameACCKFocus
Antihypertensive Agents331Locked
Nitric Oxide Enhancer212Locked
Cardiotonic Agents110Locked
Fertility Agents: Male110Locked
Anti-Inflammatory Agents23Locked
Antioxidants12Locked
Cardioprotective12Locked
Interleukin-6 Downregulation12Locked
Neuroprotective Agents12Locked
Prophylactic Agents12Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor12Locked
Hypoglycemic Agents11Locked

View the Evidence:
46 Abstracts with Citrulline Research

[+]

The effects of combined exercise with citrulline supplementation on body composition and lower limb function of overweight older adults.Aug 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Sports Sci Med. 2023 Sep ;22(3):541-548. Epub 2023 Sep 1. PMID: 37711701
Article Published Date : Aug 31, 2023
Study Type : Meta Analysis, Review
Additional Links
Substances : Citrulline
Diseases : Athletic Performance, Overweight
Therapeutic Actions : Exercise
[+]

L-citrulline supplementation may reduce systolic blood pressure.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2019 Jan-Feb;9(1):10-20. PMID: 30788274
Article Published Date : Dec 31, 2018
Study Type : Meta Analysis, Review
Additional Links
Substances : Citrulline
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
[+]

Watermelon supplementation reduces arterial stiffness and aortic systolic blood pressure.Apr 30, 2013

Pubmed Data : Menopause. 2013 May ;20(5):573-7. PMID: 23615650
Article Published Date : Apr 30, 2013
Study Type : Human Study
Additional Links
Substances : Citrulline, Watermelon
Diseases : Arterial Hardening: Elasticity, Hypertension, Obesity
Pharmacological Actions : Antihypertensive Agents
Additional Keywords : Plant Extracts
[+]

A single fashion watermelon juice enriched in l-citrulline dose diminished muscle soreness perception from 24 to 72 h after a marathon race.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Nutr Res. 2017 ;61(1):1330098. Epub 2017 Jun 13. PMID: 28659740
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : Citrulline, Watermelon
Diseases : Athletic Performance: Recovery , Muscle Soreness
[+]

Administration of L-arginine and citrulline to patients improve the condition of heart failure patients with preserved ejection fraction.Jan 01, 2010

Pubmed Data : Cardiol J. 2010;17(6):612-8. PMID: 21154265
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Substances : Arginine, Citrulline
Diseases : Heart Failure, Hypertension
Pharmacological Actions : Cardiotonic Agents
[+]

Citrulline and spirulina may have a therapeutic role in the management of sickle cell disease. Oct 15, 2006

Pubmed Data : Cancer Res. 2006 Oct 15;66(20):10064-72. PMID: 20089363
Article Published Date : Oct 15, 2006
Study Type : Human Study
Additional Links
Substances : Citrulline, Spirulina
Diseases : Anemia: Sickle Cell
[+]

Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness.May 01, 2010

Pubmed Data : J Strength Cond Res. 2010 May;24(5):1215-22. PMID: 20386132
Article Published Date : May 01, 2010
Study Type : Human Study
Additional Links
Substances : Citrulline
Diseases : Athletic Performance, Athletic Performance: Recovery , Muscle Soreness: Exercise-Induced
[+]

Citrulline with high-intensity interval training induces greater improvements in upper limbs muscle strength and walking speed in dynapenic-obese elderly.Dec 16, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Med. 2018 Dec 17 ;7(12). Epub 2018 Dec 17. PMID: 30562948
Article Published Date : Dec 16, 2018
Study Type : Human Study
Additional Links
Substances : Citrulline
Diseases : Obesity
Therapeutic Actions : Exercise: Aerobic
[+]

Combined effects of citrulline plus nitrate-rich beetroot extract co-supplementation on maximal and endurance-strength and aerobic power.Dec 22, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2021 Dec 23 ;14(1). Epub 2021 Dec 23. PMID: 35010917
Article Published Date : Dec 22, 2021
Study Type : Human Study
Additional Links
Substances : Beet, Citrulline
Diseases : Athletic Performance
Therapeutic Actions : Exercise: Aerobic, Exercise: Endurance
Additional Keywords : Plant Extracts
[+]

Consumption of watermelon juice enriched in I-citrulline and pomegranate ellagitannins enhanced metabolism during physical exercise.Jun 06, 2017

Pubmed Data : J Agric Food Chem. 2017 Jun 7 ;65(22):4395-4404. Epub 2017 May 26. PMID: 28513179
Article Published Date : Jun 06, 2017
Study Type : Human Study
Additional Links
Substances : Citrulline, Pomegranate, Watermelon
Diseases : Muscle Damage
Therapeutic Actions : Exercise
[+]

Efficacy of citrulline supplementation to decrease the risk of pulmonary hypertension after congenital heart disease surgery.Dec 31, 2019

Pubmed Data : Rev Fac Cien Med Univ Nac Cordoba. 2020 12 1 ;77(4):249-253. Epub 2020 Dec 1. PMID: 33351387
Article Published Date : Dec 31, 2019
Study Type : Human Study
Additional Links
Substances : Citrulline
Diseases : Heart Disease: Congenital, Hypertension: Pulmonary
Pharmacological Actions : Cardioprotective
[+]

Grape seed extract may act as an ergogenic aid that can improve O2 delivery to exercising muscles.Dec 31, 2022

Pubmed Data : J Diet Suppl. 2023 ;20(4):531-542. Epub 2022 Jan 4. PMID: 37293750
Article Published Date : Dec 31, 2022
Study Type : Human Study
Additional Links
Substances : Citrulline, Grape Seed Extract
Diseases : Athletic Performance
Therapeutic Actions : Exercise
[+]

Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation.Dec 31, 2011

Pubmed Data : Cardiol J. 2012 ;19(6):612-7. PMID: 23224924
Article Published Date : Dec 31, 2011
Study Type : Human Study
Additional Links
Substances : Citrulline
Diseases : Heart Failure, Left Ventricular Dysfunction
[+]

L-Citrulline increases nitric oxide and improves control in obese asthmatics.Jan 18, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : JCI Insight. 2019 12 19 ;4(24). Epub 2019 Dec 19. PMID: 31714895
Article Published Date : Jan 18, 2019
Study Type : Human Study
Additional Links
Substances : Citrulline
Diseases : Asthma, Obesity, Oxidative Stress
Pharmacological Actions : Nitric Oxide Enhancer
[+]

L-citrulline significantly improved subjective feelings of muscle fatigue and concentration immediately after exercise.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Int Soc Sports Nutr. 2016 ;13:6. Epub 2016 Feb 19. PMID: 26900386
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Substances : Citrulline
Diseases : Muscle Soreness
Therapeutic Actions : Exercise, Exercise: Cycling
[+]

L-citrulline supplementation and exercise in the management of sarcopenia. Sep 07, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2021 Sep 8 ;13(9). Epub 2021 Sep 8. PMID: 34579009
Article Published Date : Sep 07, 2021
Study Type : Human Study
Additional Links
Substances : Citrulline
Diseases : Sarcopenia
Therapeutic Actions : Exercise
[+]

L-citrulline supplementation improved leg endothelial function in hypertensive postmenopausal women.Dec 22, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2022 Dec 23 ;15(1). Epub 2022 Dec 23. PMID: 36615732
Article Published Date : Dec 22, 2022
Study Type : Human Study
Additional Links
Substances : Citrulline
Diseases : Hypertension
Therapeutic Actions : Exercise: Resistance Training
Pharmacological Actions : Vasodilator Agents
[+]

L-citrulline supplementation might improve glucose homeostasis, some lipid factors and inflammatory markers in overweight and obese patients with T2D.May 31, 2021

Pubmed Data : Phytother Res. 2021 Jun ;35(6):3157-3166. Epub 2021 Apr 20. PMID: 33876875
Article Published Date : May 31, 2021
Study Type : Human Study
Additional Links
Substances : Citrulline
Diseases : Diabetes Mellitus: Type 2, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic
[+]

One week of L-citrulline supplementation improves performance in trained cyclists.Feb 29, 2020

Pubmed Data : J Strength Cond Res. 2020 Mar ;34(3):647-652. PMID: 31860534
Article Published Date : Feb 29, 2020
Study Type : Human Study
Additional Links
Substances : Citrulline
Diseases : Athletic Performance
Therapeutic Actions : Exercise: Cycling
[+]

Oral L-citrulline supplementation attenuates blood pressure response to cold pressor test in young men.Jan 01, 2010

Pubmed Data : Am J Hypertens. 2010 Jan;23(1):12-6. Epub 2009 Oct 22. PMID: 19851298
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Substances : Citrulline
Diseases : Hypertension
[+]

Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction.Jan 01, 2011

Pubmed Data : Urology. 2011 Jan;77(1):119-22. PMID: 21195829
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Substances : Citrulline
Diseases : Erectile Dysfunction
[+]

Short-term l-citrulline supplementation may functionally improve arterial stiffness, independent of blood pressure, in humans.Nov 08, 2010

Pubmed Data : Int J Cardiol. 2010 Nov 8. Epub 2010 Nov 8. PMID: 21067832
Article Published Date : Nov 08, 2010
Study Type : Human Study
Additional Links
Substances : Citrulline
Diseases : Arterial Hardening: Elasticity
Pharmacological Actions : Nitric Oxide Enhancer
[+]

Supplementation with Prelox R enhanced sperm volume and concentration, motility, vitality and morphology.Nov 30, 2014

Pubmed Data : Minerva Urol Nefrol. 2014 Dec ;66(4):217-23. PMID: 25531191
Article Published Date : Nov 30, 2014
Study Type : Human Study
Additional Links
Substances : Arginine, Citrulline, Pycnogenol (Pine Bark)
Diseases : Sperm Count: Low
Pharmacological Actions : Fertility Agents: Male
Additional Keywords : Phytotherapy, Plant Extracts
[+]

The administration of L-arginine and citrulline has a beneficial effect on endothelial function in the treatment of heart failure.Jan 01, 2010

Pubmed Data : Cardiol J. 2010;17(5):464-70. PMID: 20865676
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Substances : Arginine, Citrulline
Diseases : Endothelial Dysfunction, Heart Failure
[+]

The effect of branched-chain amino acids, citrulline, and arginine on high-intensity interval performance in young swimmers.Dec 13, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Dec 14 ;10(12). Epub 2018 Dec 14. PMID: 30558143
Article Published Date : Dec 13, 2018
Study Type : Human Study
Additional Links
Substances : Arginine, Citrulline
Diseases : Athletic Performance
Therapeutic Actions : Exercise, Exercise: Swimming
[+]

The effect of L-citrulline supplementation on outcomes of critically ill patients under mechanical ventilation.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Acad Emerg Med. 2023 ;11(1):e11. Epub 2023 Jan 1. PMID: 36620736
Article Published Date : Dec 31, 2022
Study Type : Human Study
Additional Links
Substances : Citrulline
Diseases : Respiratory Distress Syndrome
Additional Keywords : Risk Reduction, Ventilator Mortality
[+]

Watermelon juices (and/or L-citrulline) help to reduce the recovery heart rate and the muscle soreness after 24 h.Jul 16, 2013

Pubmed Data : J Agric Food Chem. 2013 Jul 17. Epub 2013 Jul 17. PMID: 23862566
Article Published Date : Jul 16, 2013
Study Type : Human Study
Additional Links
Substances : Citrulline, Watermelon
Diseases : Muscle Damage: Exercise-Induced, Muscle Soreness: Exercise-Induced
[+]

Citrulline has protective effects on the hearts of rats with sepsis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2018 ;2018:2574501. Epub 2018 Oct 18. PMID: 30498752
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Citrulline
Diseases : Sepsis
Pharmacological Actions : Cardioprotective
[+]

Citrulline increases protein synthesis and protein content in the muscle in old malnourished rats. Sep 01, 2006

Pubmed Data : Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E582-6. Epub 2006 Apr 11. PMID: 16608884
Article Published Date : Sep 01, 2006
Study Type : Animal Study
Additional Links
Substances : Citrulline
Diseases : Sarcopenia
Additional Keywords : Anabolic, Protein Energ Malnutrition
[+]

Citrulline malate has a beneficial effect on skeletal muscle function in the endotoxemic rat.Jan 05, 2009

Pubmed Data : Eur J Pharmacol. 2009 Jan 5;602(1):143-7. Epub 2008 Nov 17. PMID: 19036344
Article Published Date : Jan 05, 2009
Study Type : Animal Study
Additional Links
Substances : Citrulline
Diseases : Endotoxemia, Klebsiella Infections
[+]

Citrulline might represent a new pharmacological strategy in OSA patients with high cardiovascular risk.Nov 23, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2022 Nov 24 ;11(12). Epub 2022 Nov 24. PMID: 36552534
Article Published Date : Nov 23, 2022
Study Type : Animal Study
Additional Links
Substances : Citrulline
Diseases : Sleep Apnea: Obstructive
Pharmacological Actions : Antihypertensive Agents
[+]

Citrulline supplementation may be a promising preventive nutritional approach to limit age-related cognitive decline.Dec 26, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 Dec 27 ;9(1):20138. Epub 2019 Dec 27. PMID: 31882891
Article Published Date : Dec 26, 2019
Study Type : Animal Study
Additional Links
Substances : Citrulline
Diseases : Aging, Cognitive Decline/Dysfunction
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Risk Reduction
[+]

Citrulline/malate promotes aerobic energy production in human exercising muscle.Aug 01, 2002

Pubmed Data : Br J Sports Med. 2002 Aug;36(4):282-9. PMID: 12145119
Article Published Date : Aug 01, 2002
Study Type : Animal Study
Additional Links
Substances : Citrulline
Diseases : Athletic Performance, Mitochondrial Dysfunction
[+]

L-Citrulline ameliorates chronic hypoxia-induced pulmonary hypertension in newborn piglets.Sep 01, 2009

Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 2009 Sep;297(3):L506-11. Epub 2009 Jul 17. PMID: 19617312
Article Published Date : Sep 01, 2009
Study Type : Animal Study
Additional Links
Substances : Citrulline
Diseases : Hypertension: Pulmonary, Hypoxia
Pharmacological Actions : Nitric Oxide Enhancer
[+]

L-citrulline enriched fermented milk with Lactobacillus helveticus attenuates dextran sulfate sodium (DSS) induced colitis.Dec 31, 2021

Pubmed Data : J Nutr Biochem. 2022 01 ;99:108858. Epub 2021 Sep 26. PMID: 34587540
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Citrulline, Lactobacillus helveticus
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-4 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Preventive effects of citrulline on Western diet-induced non-alcoholic fatty liver disease.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Nutr. 2016 07 ;116(2):191-203. Epub 2016 May 20. PMID: 27197843
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Citrulline
Diseases : Inflammation, Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Supplementing with citrulline has protective effects on the development of NAFLD in mice.Aug 04, 2016

Pubmed Data : Eur J Nutr. 2016 Aug 5. Epub 2016 Aug 5. PMID: 27496089
Article Published Date : Aug 04, 2016
Study Type : Animal Study
Additional Links
Substances : Citrulline
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Prophylactic Agents
[+]

The consumption of watermelon (a rich source of citrulline) results in elevated plasma arginine levels.Mar 01, 2007

Pubmed Data : Nutrition. 2007 Mar;23(3):261-6. PMID: 17352962
Article Published Date : Mar 01, 2007
Study Type : Animal Study
Additional Links
Substances : Citrulline, Watermelon
[+]

The effects of L-citrulline adjunctive treatment of Toxoplasma gondii RH strain infection.Jan 09, 2023

Pubmed Data : Acta Trop. 2023 Jan 10 ;239:106830. Epub 2023 Jan 10. PMID: 36638878
Article Published Date : Jan 09, 2023
Study Type : Animal Study
Additional Links
Substances : Citrulline
Diseases : Toxoplasma gondii Infection, Toxoplasmosis
Pharmacological Actions : Anti-Inflammatory Agents, Antiparasitic Agents, Hepatoprotective
[+]

Watermelon pomace (rich in citrulline) significantly ameliorates the metabolic syndrome in diabetic fatty rats. Dec 01, 2007

Pubmed Data : J Nutr. 2007 Dec;137(12):2680-5. PMID: 18029483
Article Published Date : Dec 01, 2007
Study Type : Animal Study
Additional Links
Substances : Citrulline, Watermelon
Diseases : Metabolic Syndrome X
[+]

Citrulline enteral administration markedly reduces immunosuppressive extrafollicular plasma cell differentiation in a preclinical model of sepsis.Dec 22, 2022

Pubmed Data : Eur J Immunol. 2022 Dec 23:e2250154. Epub 2022 Dec 23. PMID: 36564641
Article Published Date : Dec 22, 2022
Study Type : In Vitro Study
Additional Links
Substances : Citrulline
Diseases : Sepsis
Pharmacological Actions : Immunomodulatory
[+]

Influence of L-citrulline and watermelon supplementation on vascular function and exercise performance.Dec 31, 2016

Pubmed Data : Curr Opin Clin Nutr Metab Care. 2017 01 ;20(1):92-98. PMID: 27749691
Article Published Date : Dec 31, 2016
Study Type : Review
Additional Links
Substances : Arginine, Citrulline, Watermelon
Diseases : Athletic Performance, Hypertension
Therapeutic Actions : Exercise
Pharmacological Actions : Antihypertensive Agents
[+]

L-citrulline supplementation can enhance exercise performance and recovery.Jan 21, 2020

Pubmed Data : J Strength Cond Res. 2020 Jan 22. Epub 2020 Jan 22. PMID: 31977835
Article Published Date : Jan 21, 2020
Study Type : Review
Additional Links
Substances : Citrulline
Diseases : Athletic Performance, Athletic Performance: Recovery
Therapeutic Actions : Exercise: Cycling
[+]

Metabolic effects of L-citrulline in type 2 diabetes.Jan 15, 2023

Pubmed Data : Acta Physiol (Oxf). 2023 Jan 16:e13937. Epub 2023 Jan 16. PMID: 36645144
Article Published Date : Jan 15, 2023
Study Type : Review
Additional Links
Substances : Citrulline
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Hypolipidemic
[+]

Potential roles of Citrulline and watermelon extract on metabolic and inflammatory variables in diabetes mellitus.Jan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Exp Pharmacol Physiol. 2020 Feb ;47(2):187-198. Epub 2019 Nov 17. PMID: 31612510
Article Published Date : Jan 31, 2020
Study Type : Review
Additional Links
Substances : Citrulline, Watermelon
Diseases : Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 2
Pharmacological Actions : Anti-Inflammatory Agents, Hypoglycemic Agents
[+]

Citrulline improves nitric oxide synthesis and improves cardiovascular function in a sustainable way.Dec 01, 2010

Pubmed Data : Curr Pharm Biotechnol. 2010 Dec;11(8):794-800. PMID: 17214603
Article Published Date : Dec 01, 2010
Additional Links
Substances : Citrulline

Copyright: molekuul / 123RF Stock Photo

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