CLA (Conjugated Linoleic Acid)

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26 Diseases Researched for CLA (Conjugated Linoleic Acid)
NameACCKFocus
Obesity313Locked
Athletic Performance: Strength110Locked
Breast Milk: Inadequate/Poor Quality110Locked
Erythrocyte Sedimentation Rate (ESR): Elevated110Locked
Rheumatoid Arthritis110Locked
Abdominal Obesity (Midsection Fat)12Locked
Allergic Airway Diseases12Locked
Allergies12Locked
Apolipoprotein Disorders12Locked
Bladder Cancer22Locked
Colitis12Locked
Dyslipoproteinemias12Locked
Gastrointestinal Inflammation12Locked
Gluten Sensitivity12Locked
High Cholesterol12Locked
Inflammatory Bowel Diseases12Locked
Muscle Atrophy 12Locked
Osteoporosis: Steroid-Induced12Locked
Overweight 12Locked
Polycystic Kidney Diseases12Locked
Prostate Cancer12Locked
Sarcopenia12Locked
Weight Problems12Locked
Breast Cancer11Locked
Cardiovascular Diseases11Locked
Colon Cancer11Locked
10 Pharmacological Actions Researched for CLA (Conjugated Linoleic Acid)
NameACCKFocus
Antioxidants110Locked
Apoptotic34Locked
Antiproliferative 23Locked
Anabolic Agents12Locked
Anti-Adipogenic12Locked
Anti-Allergic Agents12Locked
Insulin-Like Growth Factor Inhibition/Downregulation22Locked
Estrogen Receptor Modulators11Locked
Selective Estrogen Receptor Modulators11Locked
Selective estrogen enzyme modulator (SEEM)11Locked

View the Evidence:
29 Abstracts with CLA (Conjugated Linoleic Acid) Research

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An organic diet increases the amount of beneficial CLA and trans-vaccenic acid in human breast milk. Apr 01, 2007

Pubmed Data : Br J Nutr. 2007 Apr;97(4):735-43. PMID: 17349086
Article Published Date : Apr 01, 2007
Study Type : Human Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid), Vaccenic acid
Diseases : Breast Milk: Inadequate/Poor Quality
Additional Keywords : Organic Versus Conventional
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Conjugated linoleic acid and safflower oil improve body composition in obese postmenopausal women with type 2 diabetes mellitus.Sep 01, 2009

Pubmed Data : Am J Clin Nutr. 2009 Sep;90(3):468-76. Epub 2009 Jun 17. PMID: 19535429
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid), Safflower
Diseases : Obesity
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Conjugated linoleic acid and vitamin E supplementation reduces inflammation in patients with active rheumatoid arthritis.Apr 01, 2009

Pubmed Data : Int J Rheum Dis. 2009 Apr;12(1):20-8. PMID: 20374312
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid), Vitamin E
Diseases : Erythrocyte Sedimentation Rate (ESR): Elevated, Rheumatoid Arthritis
Pharmacological Actions : Antioxidants
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Conjugated linoleic acid combined with creatine monohydrate and whey protein supplementation improve strength and lean-tissue mass during heavy during resistance training. Feb 01, 2009

Pubmed Data : Int J Sport Nutr Exerc Metab. 2009 Feb;19(1):79-96. PMID: 19403955
Article Published Date : Feb 01, 2009
Study Type : Human Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid), Creatine, Whey
Diseases : Athletic Performance: Strength
Additional Keywords : Drug-Plant-Vitamin Synergies
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Bovine milk fat enriched in conjugated linoleic and vaccenic acids attenuates allergic airway disease in mice.Jan 01, 2008

Pubmed Data : Clin Exp Allergy. 2008 Jan;38(1):208-18. Epub 2007 Nov 13. PMID: 18005183
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Butter, CLA (Conjugated Linoleic Acid), Vaccenic acid
Diseases : Allergic Airway Diseases, Allergies
Pharmacological Actions : Anti-Allergic Agents
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Butter naturally enriched in conjugated linoleic acid and vaccenic acid alters tissue fatty acids and improves the plasma lipoprotein profile in cholesterol-fed hamsters.Aug 01, 2005

Pubmed Data : J Nutr. 2005 Aug;135(8):1934-9. PMID: 16046719
Article Published Date : Aug 01, 2005
Study Type : Animal Study
Additional Links
Substances : Butter, CLA (Conjugated Linoleic Acid), Vaccenic acid
Diseases : Apolipoprotein Disorders, Dyslipoproteinemias
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Butter naturally enriched with conjugated linoleic acid and vaccenic acid has a beneficial effect on serum fatty acid composition in growing pigs.Jan 01, 2008

Pubmed Data : Lipids Health Dis. 2008;7:31. Epub 2008 Aug 29. PMID: 18759970
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Butter, CLA (Conjugated Linoleic Acid), Vaccenic acid
Diseases : High Cholesterol
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CLA and Omega 3 fatty acids are therapeutic in experimental inflammatory bowel disease. Jun 01, 2006

Pubmed Data : Clin Nutr.2006 Jun;25(3):454-65. Epub 2006 May 15. PMID: 16698153
Article Published Date : Jun 01, 2006
Study Type : Animal Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid), Omega-3 Fatty Acids
Diseases : Inflammatory Bowel Diseases
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CLA attenuates porcine bacterial-induced colitis.Jul 01, 2002

Pubmed Data : J Nutr. 2002 Jul;132(7):2019-27. PMID: 12097686
Article Published Date : Jul 01, 2002
Study Type : Animal Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid)
Diseases : Colitis
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CLA reduces gliadin-induced intestinal toxicity in an animal model. Sep 01, 2011

Pubmed Data : Mol Nutr Food Res. 2011 Sep ;55 Suppl 2:S248-56. Epub 2011 Aug 31. PMID: 21954188
Article Published Date : Sep 01, 2011
Study Type : Animal Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid)
Diseases : Gastrointestinal Inflammation, Gluten Sensitivity
Problem Substances : Gliadin
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Conjugated linoleic acid and chromium lower body weight and visceral fat mass in high fat fed mice. Sep 01, 2009

Pubmed Data : J Ren Nutr. 2009 Sep;19(5):389-95. Epub 2009 Jul 3. PMID: 16933788
Article Published Date : Sep 01, 2009
Study Type : Animal Study
Additional Links
Substances : Chromium, CLA (Conjugated Linoleic Acid)
Diseases : Abdominal Obesity (Midsection Fat), Overweight
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Conjugated linoleic acid prevents age-associated skeletal muscle loss (sarcopenia). Jun 12, 2009

Pubmed Data : Biochem Biophys Res Commun. 2009 Jun 12;383(4):513-8. Epub 2009 Apr 22. PMID: 19393220
Article Published Date : Jun 12, 2009
Study Type : Animal Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid)
Diseases : Sarcopenia
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Conjugated linoleic acid prevents growth attenuation induced by corticosteroids and increases bone mineral content in young rats Dec 01, 2008

Pubmed Data : Appl Physiol Nutr Metab. 2008 Dec;33(6):1096-104. PMID: 19088767
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid)
Diseases : Osteoporosis: Steroid-Induced
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Dietary coconut oil increases conjugated linoleic acid-induced body fat loss in mice.Oct 15, 2005

Pubmed Data : Biochim Biophys Acta. 2005 Oct 15;1737(1):52-60. Epub 2005 Sep 13. PMID: 16216548
Article Published Date : Oct 15, 2005
Study Type : Animal Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid), Coconut, Coconut Oil
Diseases : Weight Problems
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Dietary conjugated linolenic acid reduces renal inury in a rat model of polycystic kidney disease. Apr 01, 2007

Pubmed Data : J Urol. 2007 Apr;177(4):1358-62; discussion 1362; quiz 1591. PMID: 18629561
Article Published Date : Apr 01, 2007
Study Type : Animal Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid)
Diseases : Polycystic Kidney Diseases
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Dietary supplementation of L-arginine and conjugated linoleic acid reduces retroperitoneal fat mass and increases lean body mass in rats.Jul 01, 2009

Pubmed Data : J Nutr. 2009 Jul;139(7):1279-85. Epub 2009 May 13. PMID: 19439462
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Arginine, CLA (Conjugated Linoleic Acid)
Diseases : Muscle Atrophy , Obesity
Pharmacological Actions : Anabolic Agents, Anti-Adipogenic
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White button mushroom and its major component, CLA, exhibits antiproliferative and proapoptotic properties and inhibits prostate tumor growth in athymic mice.Jan 01, 2008

Pubmed Data : Nutr Cancer. 2008;60(6):744-56. PMID: 19005974
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid), White Button Mushroom
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
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CLA inhibits cell proliferation and increases programmed cell death in human bladder cancer cells. Feb 01, 2010

Pubmed Data : J Med Food. 2010 Feb;13(1):13-9. PMID: 20136431
Article Published Date : Feb 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid)
Diseases : Bladder Cancer
Pharmacological Actions : Apoptotic, Insulin-Like Growth Factor Inhibition/Downregulation
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CLA inhibits the growth of human colon cancer cells via the downregulation of IGF-1 receptor levels. Aug 01, 2003

Pubmed Data : J Nutr. 2003 Aug;133(8):2675-81. PMID: 12888657
Article Published Date : Aug 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid)
Diseases : Colon Cancer
Pharmacological Actions : Insulin-Like Growth Factor Inhibition/Downregulation
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Conjugated linoleic acid inhibits DNA synthesis and induces programmed cell death in human bladder cancer cells.Nov 01, 2003

Pubmed Data : Anticancer Res. 2003 Nov-Dec;23(6C):4765-72. PMID: 14981924
Article Published Date : Nov 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid)
Diseases : Bladder Cancer
Pharmacological Actions : Apoptotic
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Green tea and caffeine have data to back up its fat metabolism-enhancing properties.Oct 01, 2011

Pubmed Data : Obes Rev. 2011 Oct ;12(10):841-51. PMID: 21951331
Article Published Date : Oct 01, 2011
Study Type : Commentary
Additional Links
Substances : B-complex, Caffeine, Carnitine, CLA (Conjugated Linoleic Acid), Fucoxanthin , Green Tea, Taurine, Tea
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Pomegranate seed compounds have estrogen receptor enzyme modulating activity.Aug 01, 2007

Pubmed Data : Atherosclerosis. 2007 Aug;193(2):277-82. Epub 2006 Sep 29. PMID: 20136514
Article Published Date : Aug 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid), Pomegranate
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Estrogen Receptor Modulators, Selective estrogen enzyme modulator (SEEM), Selective Estrogen Receptor Modulators
Additional Keywords : Estrogen Receptor Beta
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This study outlines dietary factors promoting brown and beige fat development and thermogenesis.May 01, 2017

Pubmed Data : Adv Nutr. 2017 May ;8(3):473-483. Epub 2017 May 15. PMID: 28507012
Article Published Date : May 01, 2017
Study Type : Review
Additional Links
Substances : Berberine, Capsaicin, CLA (Conjugated Linoleic Acid), Curcumin, Fish Oil, Green Tea, Resveratrol, Turmeric, Vitamin A
Diseases : Obesity
Additional Keywords : Plant Extracts
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Vaccenic acid is a dietary precursor of conjugated linoleic acid (CLA) and may have health benefits beyond those associated with CLA.Jan 01, 2007

Pubmed Data : Medicina (Kaunas). 2007;43(8):597-606. PMID: 19935865
Article Published Date : Jan 01, 2007
Study Type : Review
Additional Links
Substances : CLA (Conjugated Linoleic Acid), Vaccenic acid
Diseases : Cardiovascular Diseases
Additional Keywords : Substances that are Linked
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CLA produces a modest loss in body fat in humans.May 01, 2007

Pubmed Data : Am J Clin Nutr. 2007 May;85(5):1203-11. PMID: 17490954
Article Published Date : May 01, 2007
Additional Links
Substances : CLA (Conjugated Linoleic Acid)
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CLA protects against fat mass regain following weight loss.Oct 01, 2007

Pubmed Data : J Food Sci. 2007 Oct;72(8):S612-7. PMID: 17995628
Article Published Date : Oct 01, 2007
Additional Links
Substances : CLA (Conjugated Linoleic Acid)
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CLA reduces body fat content in mice.Dec 01, 2009

Pubmed Data : Cancer Biother Radiopharm. 2009 Dec;24(6):675-80. PMID: 10198400
Article Published Date : Dec 01, 2009
Additional Links
Substances : CLA (Conjugated Linoleic Acid)
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CLA safely reduces body fat mass (BFM) in healthy, overweight and obese adults.Mar 01, 2007

Pubmed Data : Br J Nutr. 2007 Mar;97(3):550-60. PMID: 17313718
Article Published Date : Mar 01, 2007
Additional Links
Substances : CLA (Conjugated Linoleic Acid)
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CLA safely reduces body fat mass in healthy overweight humans.Apr 01, 2005

Pubmed Data : J Nutr. 2005 Apr;135(4):778-84. PMID: 15795434
Article Published Date : Apr 01, 2005
Additional Links
Substances : CLA (Conjugated Linoleic Acid)

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