Coenzyme Q10

Name	AC	CK
Heart Failure	25	210
Oxidative Stress	26	198
Inflammation	20	189
C-Reactive Protein	5	80
Headache: Migraine	7	80
Statin-Induced Pathologies	13	72
Diabetes Mellitus: Type 2	11	68
Parkinson's Disease	12	63
Infertility: Male	7	62
Congestive Heart Failure	5	61
Hypertension	10	47
Endothelial Dysfunction	7	44
Asthenozoospermia	3	40
Atherosclerosis	4	40
Cardiac Mortality	4	40
Polycystic Ovary Syndrome	4	40
Myocardial Infarction	6	35
Cholesterol: Oxidation	5	34
Sepsis	5	34
Migraine Disorders	6	33
Aging	5	31
Muscle Damage: Exercise-Induced	3	30
Sperm Quality: Low	2	30
Cardiovascular Diseases	8	27
Depression	4	24
Diabetes: Oxidative Stress	4	24
Drug-Induced Nutrient Depletion: Statin Drugs	5	24
Amyotrophic Lateral Sclerosis	4	23
Fibromyalgia	4	22
Hyperglycemia	2	22
Breast Cancer	3	21
Fatigue	3	21
Coenzyme Q10 Deficiency	2	20
Cystic Fibrosis	2	20
Dry Mouth	1	20
Mineral Deficiencies: Selenium	2	20
Multiple Sclerosis	2	20
Prenatal Nutrition	1	20
Rheumatoid Arthritis	2	20
Trisomy 21	1	20
Chemotherapy-Induced Toxicity: Cisplatin	5	17
Insulin Resistance	3	17
Cognitive Decline/Dysfunction	4	15
Hypercholesterolemia	3	14
Lipid Peroxidation	3	14
Pre-Eclampsia	3	14
Spinal Cord Injuries	4	14
Cardiomyopathy	2	13
Diabetic Nephropathy	3	13
Infertility: Female	3	13
DNA damage	2	12
Nonalcoholic fatty liver disease (NAFLD)	2	12
Psoriasis	2	12
Atrial Fibrillation	2	11
Heart Disease: Ischemic	2	11
Liver Cancer	2	11
Alzheimer's Disease	6	10
Arterial Hardening: Elasticity	1	10
Autism Spectrum Disorders	1	10
Bipolar Disorder	1	10
Cholesterol: LDL/HDL ratio	1	10
Chronic Fatigue Syndrome	1	10
Coronary Artery Disease	1	10
Deafness: Maternally Inherited (with Diabetes)	1	10
Death: Statin-Induced	1	10
Dementia	1	10
Depression: Bipolar	1	10
Depression: Multiple Sclerosis	1	10
Diabetes: Glycation/A1C	1	10
Diabetes: Maternally Inherited (with deafness)	1	10
Diabetic Polyneuropathy	1	10
Down Syndrome	1	10
Fatigue: Excercise-Induced	1	10
Headache	1	10
Heart Dysfunction: Ejection Fraction, Low	1	10
Hemodialysis	1	10
Hemoglobinopathies	1	10
Herpes family viruses	1	10
High Cholesterol	1	10
Human Papillomavirus (HPV)	1	10
Kidney Failure: Chronic	1	10
Left Ventricular Dysfunction	1	10
Left Ventricular Hypertrophy	1	10
Macular Degeneration	1	10
Maternally inherited diabetes mellitus and deafness (MIDD)	1	10
Metabolic Diseases	1	10
Migraines	1	10
Mitochondrial Diseases	1	10
Multiple System Atrophy	1	10
Myelodysplastic Syndrome	1	10
Myelodysplastic Syndromes	1	10
Myocardial Fibrosis	1	10
Myopathy	1	10
Petroleum Exposure And Toxicity	1	10
Post-Polio Syndrome	1	10
Prediabetes	1	10
Prostate: PSA Doubling	1	10
Quality of Life: Poor	1	10
Spinal Cord Inflammation	1	10
Tachycardia	1	10
Thalassemia	1	10
Tinnitus	1	10
Triglycerides: Elevated	1	10
Mitochondrial Dysfunction	5	8
Huntington Disease	4	7
Ascites	3	6
Lipopolysaccharide-Induced Toxicity	4	6
Myocardial Ischemia	3	6
Fibrosis	3	5
Kidney Diseases	2	5
Allergic Rhinitis	2	4
Arteriosclerosis	2	4
Bisphenol Toxicity	2	4
Brain Ischemia	2	4
Cerebral Ischemia	2	4
Chemically-Induced Liver Damage	2	4
Diabetes: Cognitive Dysfunction	2	4
Glaucoma	3	4
Lead Poisoning	2	4
Metabolic Syndrome X	2	4
Neurodegenerative Diseases	3	4
Traumatic Brain Injury	2	4
Ulcerative Colitis	2	4
Aging: Brain	2	3
Brain Damage	2	3
Glioblastoma	2	3
Hyperlipidemia	2	3
Memory Disorders: Drug-Induced	1	3
Osteoporosis	2	3
Periodic Paralysis: Familial	1	3
Ultraviolet Radiation Induced Damage	2	3
Aging: Heart	1	2
Amyotrophic lateral sclerosis (ALS)	1	2
Antiphospholipid Syndrome	1	2
Arsenic Poisoning	1	2
Asthma	1	2
Autism	1	2
Bladder Dysfunction	1	2
Brain Injury: Traumatic	1	2
Brain: Microglial Activation	1	2
Brain: Oxidative Stress	1	2
Burns	1	2
Cadmium Poisoning	1	2
Cancers: Drug Resistant	1	2
Cardiomyopathy: Dilated	1	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Toxicity	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Colitis	1	2
Dermatitis	1	2
Diabetic Neuropathies	1	2
Drug Toxicity: Isoprenaline	1	2
Drug Toxicity: Methotrexate	1	2
Enteropathy	1	2
Exercise-Induced Tissue Damage	1	2
Eye Damage	1	2
Fatty Liver	1	2
Fructose-Induced Toxicity	1	2
Gingivitis	1	2
Glomerulosclerosis	1	2
HIV Protease Inhibitor Ritonavir Toxicity	1	2
Hearing Loss: Noise-Induced	1	2
Heart Attack: Recovery	1	2
High Fructose Diet	1	2
Hyperalgesia	1	2
Infertility	1	2
Kidney Damage: Chemically-Induced	1	2
Liver Damage	1	2
Liver Damage: Drug-Induced	1	2
Liver Fibrosis	1	2
Liver Stress: Fructose-Induced	1	2
Malaria	1	2
Methanol Toxicity	1	2
Muscle Soreness: Exercise-Induced	1	2
Muscular Dystrophies	1	2
Nephropathy	1	2
Neuropathic Pain	1	2
Neuropathies	1	2
Obesity	1	2
Ocular Hypertension	1	2
Osteoarthritis	1	2
Osteonecrosis	1	2
Ovarian Failure	1	2
Parkinsonian Disorders	1	2
Periodontal Diseases	1	2
Pesticide Toxicity	1	2
Postmenopausal Disorders: Memory Impairment	1	2
Radiation Induced Illness	1	2
Retinal Degeneration: Light-Induced	1	2
Sickle Cell Anemia	1	2
Sodium nitrate toxicity	1	2
Steroid-Induced Toxicity	1	2
Testicular Diseases	1	2
Testicular Injury: Cadmium-Induced	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Tuberculosis	1	2
Wound Healing	1	2
Brain Injury: Hippocampal Damage	1	1
Cancers: All	1	1
Cardiac Arrhythmias	1	1
Cardiac Hypertrophy	1	1
Chemotherapy	1	1
Chemotherapy-Induced Kidney Damage	1	1
Chronic Kidney Disease (CKD)	1	1
Diabetic Complications	1	1
Duchenne's Muscular Dystrophy	1	1
Dyslipidemias	1	1
Glucosephosphate Dehydrogenase Deficiency	1	1
HIV Drug-Induced Toxicity	1	1
Kidney Damage: Drug-Induced	1	1
Liver Disease	1	1
Multi-Organ Failure	1	1
Myocarditis: Viral	1	1
Nicotine/Tobacco Toxicity	1	1
Peritoneal cancer	1	1
Pregnancy Complications	1	1
Pregnancy-Associated Migraines	1	1
Schizophrenia	1	1

Name	AC	CK
Antioxidants	98	486
Anti-Inflammatory Agents	55	342
Interleukin-6 Downregulation	14	140
Cardioprotective	25	134
Tumor Necrosis Factor (TNF) Alpha Inhibitor	19	121
Neuroprotective Agents	33	94
Malondialdehyde Down-regulation	12	82
Prophylactic Agents	5	50
Cardiotonic Agents	2	40
Antidepressive Agents	5	34
Hypoglycemic Agents	3	31
Anticholesteremic Agents	3	30
Cardiovascular Agents	2	30
Fertility Agents: Male	3	30
Chemoprotective Agents	7	21
Hypolipidemic	3	21
Enzyme Inhibitors	2	20
Interleukin-8 downregulation	2	20
Anti-Apoptotic	11	18
Anti-Fibrotic	5	17
Hepatoprotective	9	17
Fertility Agents: Female	3	13
Catalase Up-Regulation	2	12
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	12
Superoxide Dismutase Up-regulation	2	12
Analgesics	1	10
Anti-atherogenic	1	10
Immunomodulatory	1	10
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	10
Neuritogenic	1	10
Nrf2 activation	6	10
Interleukin-1 beta downregulation	4	8
Renoprotective	6	8
Insulin Sensitizers	2	7
Antihypertensive Agents	4	5
Heme oxygenase-1 up-regulation	3	5
Osteoprotective	3	5
Pancreato Protective Agents	3	5
Radioprotective	2	4
NF-kappaB Inhibitor	2	3
Photoprotective	2	3
Anti-Allergic Agents	1	2
Anti-Asthmatic Agents	1	2
Anti-metastatic	1	2
Apoptotic	1	2
Autophagy Up-regulation	1	2
Bax/Bcl2 Ratio: Decrease	1	2
Chemotherapeutic	1	2
Genoprotective	1	2
Glutathione Upregulation	1	2
Immunomodulatory: Th17 downregulation	1	2
Interleukin-2 Downregulation	1	2
Interleukin-4 downregulation	1	2
MicroRNA modulator	1	2
Monocyte chemotattractant protein-1 (MCP-1) Inhibitor	1	2
Nitric Oxide Inhibitor	1	2
RANTES (CCL5) Inhibitor	1	2
SIRT1 Activator	1	2
STAT3 Inhibitor	1	2
Vasodilator Agents	1	2
interleukin-13 down-regulation	1	2
Anticarcinogenic Agents	1	1
Chemopreventive	1	1
Chemosensitizer	1	1
Cyclooxygenase 2 Inhibitors	1	1
Cytoprotective	1	1
Postaglandin PGE2 downregulation	1	1
Radiosensitizer	1	1
Vascular Endothelial Growth Factor Inhibitors	1	1

[+]

Coenzyme Q10 at low dose improves glucose and HbA1c levels.Jan 31, 2017

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Pubmed Data : Biofactors. 2003;18(1-4):245-54. PMID: 14695940

Article Published Date : Jan 01, 2003

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10, Methionine, Phospholipids, Selenium, Vitamin E

Diseases : Cardiovascular Diseases, Oxidative Stress, Petroleum Exposure And Toxicity

[+]

A pilot clinical study of liquid ubiquinol supplementation on cardiac function in pediatric dilated cardiomyopathy.Nov 06, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Neuro Endocrinol Lett. 2012 Nov 28 ;33(Suppl2):98-101. Epub 2012 Nov 28. PMID: 23183519

Article Published Date : Nov 27, 2012

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10

Diseases : Death: Statin-Induced, Drug-Induced Nutrient Depletion: Statin Drugs, Statin-Induced Pathologies

Problem Substances : Statin Drugs

Adverse Pharmacological Actions : Myotoxicity

[+]

AGE+CoQ10 are associated with beneficial effects on inflammatory markers and reduced progression of coronary atherosclerosis.Jun 30, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Cardiovasc Dis Res. 2012 Jul ;3(3):185-90. PMID: 22923934

Article Published Date : Jun 30, 2012

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Pubmed Data : Mol Cell Biochem. 2003 Jul;249(1-2):129-40. PMID: 12956408

Article Published Date : Jul 01, 2003

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10, Vitamin E

Diseases : Atherosclerosis, Cholesterol: Oxidation, Statin-Induced Pathologies

Pharmacological Actions : Antioxidants, Enzyme Inhibitors

[+]

Atorvastatin worsens left ventricular diastolic function, which is improved through coenzyme q10 supplementation. Nov 15, 2004

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Pubmed Data : Am J Cardiol. 2004 Nov 15 ;94(10):1306-10. PMID: 15541254

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Diabetologia. 1998 May;41(5):584-8. PMID: 9628277

Article Published Date : May 01, 1998

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10

Diseases : Deafness: Maternally Inherited (with Diabetes), Diabetes: Maternally Inherited (with deafness), Maternally inherited diabetes mellitus and deafness (MIDD)

[+]

Coenzyme Q10 improves ejection fraction as an adjunctive therapy for congestive heart failure. Oct 30, 2009

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Pubmed Data : N Z Med J. 2009 Oct 30;122(1305):74-9. PMID: 19966871

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Pubmed Data : Bratisl Lek Listy. 2020 ;121(2):154-158. PMID: 32115970

Article Published Date : Dec 31, 2019

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10

Diseases : Inflammation, Sepsis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation

Additional Keywords : Risk Reduction

[+]

Coenzyme Q10 in the treatment of attention deficit hyperactivity disorder in children.Nov 22, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : CNS Neurol Disord Drug Targets. 2021 Nov 23. Epub 2021 Nov 23. PMID: 34819012

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Pubmed Data : Mol Biol Rep. 2019 Jul 25. Epub 2019 Jul 25. PMID: 31346916

Article Published Date : Jul 24, 2019

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10

Diseases : Bipolar Disorder, Depression, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Coenzyme Q10 might have a role as a good supplement in young children with Down syndrome to ameliorate the neurological symptoms.Oct 18, 2016

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Pubmed Data : World J Mens Health. 2020 Jan 20. Epub 2020 Jan 20. PMID: 32009311

Article Published Date : Jan 19, 2020

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10

Diseases : Infertility: Male, Oxidative Stress

Pharmacological Actions : Antioxidants, Fertility Agents: Male

[+]

CoQ10 supplementation had beneficial effects in subjects with PCOS, involving glucose metabolism, serum total and LDL-cholesterol levels.Dec 01, 2016

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Pubmed Data : Clin Endocrinol (Oxf). 2016 Dec 2. Epub 2016 Dec 2. PMID: 27911471

Article Published Date : Dec 01, 2016

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10

Diseases : Polycystic Ovary Syndrome

Pharmacological Actions : Anticholesteremic Agents

[+]

CoQ10 supplementation has a beneficial effect on recovery of left ventricular function after acute ST segment elevation myocardial infarction.Jul 31, 2016

Pubmed Data : Biochim Biophys Acta. 1992 Jun 26;1126(3):247-54. PMID: 1637852

Article Published Date : Jun 26, 1992

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10, Ubiquinol

Diseases : Cholesterol: Oxidation, Oxidative Stress

[+]

Dietary supplementation with selenium and coenzyme Q10 combined reduced the inflammatory response in elderly humans.Dec 31, 2014

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Pubmed Data : PLoS One. 2015 ;10(9):e0137680. Epub 2015 Sep 16. PMID: 26375288

Article Published Date : Dec 31, 2014

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Pubmed Data : Lipids Health Dis. 2018 May 24 ;17(1):124. Epub 2018 May 24. PMID: 29793488

Article Published Date : May 23, 2018

Study Type : Human Study

Additional Links

Substances : Arginine, Coenzyme Q10, Vitamin C

Diseases : Hypercholesterolemia, Triglycerides: Elevated

Pharmacological Actions : Anticholesteremic Agents

[+]

Long-term coenzyme Q10 therapy has significant therapeutic effects in patients with advanced heart failture.Aug 01, 2005

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Pubmed Data : Wien Klin Wochenschr. 2005 Aug;117(15-16):558-60. PMID: 3836876

Article Published Date : Aug 01, 2005

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10

Diseases : Heart Failure

[+]

Long-term CoQ10 treatment of patients with chronic heart failure is safe, improves symptoms, and reduces major adverse cardiovascular events.Nov 30, 2014

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Pubmed Data : JACC Heart Fail. 2014 Dec ;2(6):641-9. Epub 2014 Oct 1. PMID: 25282031

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Pubmed Data : BMC Complement Altern Med. 2017 Aug 30 ;17(1):433. Epub 2017 Aug 30. PMID: 28854909

Article Published Date : Aug 29, 2017

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10, Feverfew, Magnesium

Diseases : Headache: Migraine

Pharmacological Actions : Prophylactic Agents

Additional Keywords : Plant Extracts

[+]

Pycnogenol® in combination with coenzymeQ10 may be of value in heart failure patients.May 31, 2010

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Pubmed Data : Panminerva Med. 2010 Jun ;52(2 Suppl 1):21-5. PMID: 20657530

Article Published Date : May 31, 2010

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10

Diseases : Heart Failure, Hypertension

[+]

Selenium and coenzyme Q10 supplementation had long lasting effects that reduced cardiovascular mortality.Dec 31, 2017

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Pubmed Data : PLoS One. 2018 ;13(4):e0193120. Epub 2018 Apr 11. PMID: 29641571

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Pubmed Data : Biofactors. 2016 May 19. Epub 2016 May 19. PMID: 27193497

Article Published Date : May 18, 2016

Study Type : Human Study

Additional Links

Substances : Ubiquinol

Diseases : Oxidative Stress

Therapeutic Actions : Exercise

Pharmacological Actions : Antioxidants

[+]

Short-term Ubiquinol-10 supplementation alleviates tissue damage in muscle and fatigue caused by strenuous exercise in male distance runners.Jan 30, 2020

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Pubmed Data : Int J Vitam Nutr Res. 2020 Jan 31:1-10. Epub 2020 Jan 31. PMID: 32003645

Pubmed Data : Minerva Endocrinol. 2015 Jul 3. Epub 2015 Jul 3. PMID: 26140473

Article Published Date : Jul 02, 2015

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypolipidemic

Additional Keywords : Significant Treatment Outcome

[+]

Supplementation with selenium and coenzyme Q10 could reduce cardiovascular mortality 10 years after supplementation. Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015 ;10(12):e0141641. Epub 2015 Dec 1. PMID: 26624886

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Pubmed Data : J Neuroinflammation. 2015 ;12(1):204. Epub 2015 Nov 6. PMID: 26545369

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Pubmed Data : Vasc Health Risk Manag. 2015 ;11:579-81. Epub 2015 Nov 6. PMID: 26604775

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Antiinflamm Antiallergy Agents Med Chem. 2021 Apr 26. Epub 2021 Apr 26. PMID: 33906592

Article Published Date : Apr 25, 2021

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Metabolic Syndrome X

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-10 upregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Antioxidant coenzyme Q10 restores fertility by rescuing bisphenol A-induced oxidative DNA damage. Dec 17, 2019

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Pubmed Data : Genetics. 2019 Dec 18. Epub 2019 Dec 18. PMID: 31852725

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Pubmed Data : J Clin Biochem Nutr. 2012 Mar ;50(2):145-51. Epub 2011 Sep 3. PMID: 22448096

Article Published Date : Mar 01, 2012

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid, Coenzyme Q10

Diseases : Fructose-Induced Toxicity , Metabolic Syndrome X, Oxidative Stress

Pharmacological Actions : Antioxidants

Problem Substances : Fructose

[+]

Coenzyme q10 appears to have significant therapeutic value in a mouse experimental model of Huntington's disease. Jun 01, 2006

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Pubmed Data : Inflammopharmacology. 2017 Jan 3. Epub 2017 Jan 3. PMID: 28050757

Article Published Date : Jan 02, 2017

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Glutathione Upregulation , Heme oxygenase-1 up-regulation, Malondialdehyde Down-regulation, Nrf2 activation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Dose Response

[+]

Coenzyme Q10 has a neuroprotective effect in an experimental model of Parkinson's disease.Mar 01, 2008

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Pubmed Data : J Neurochem. 2008 Mar;104(6):1613-21. Epub 2007 Oct 31. PMID: 17973981

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Pubmed Data : Int J Environ Res Public Health. 2019 Aug 13 ;16(16). Epub 2019 Aug 13. PMID: 31412628

Article Published Date : Aug 12, 2019

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Pubmed Data : J Mol Neurosci. 2018 Jun ;65(2):255-264. Epub 2018 Jun 14. PMID: 29948851

Article Published Date : May 31, 2018

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Spinal Cord Injuries

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Bax/Bcl2 Ratio: Decrease, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Coenzyme Q10 inhibits the activation of pancreatic stellate cells.Nov 02, 2017

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Pubmed Data : Oncotarget. 2017 Nov 3 ;8(54):92300-92311. Epub 2017 Sep 23. PMID: 29190916

Article Published Date : Nov 02, 2017

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Fibrosis

Pharmacological Actions : Anti-Fibrotic

[+]

Coenzyme Q10 may be useful as a preventing agent in steroid-induced osteonecrosis of the femoral head.Dec 31, 2013

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Pubmed Data : Acta Orthop Traumatol Turc. 2014 ;48(2):217-22. PMID: 24747633

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Pubmed Data : BMC Neurosci. 2009;10:88. Epub 2009 Jul 27. PMID: 19635141

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Oxidative Stress, Parkinson's Disease, Parkinsonian Disorders

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle.Jan 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Rocz Panstw Zakl Hig. 2001;52(3):213-8. PMID: 11771113

Article Published Date : Jan 01, 2001

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Sodium nitrate toxicity

Pharmacological Actions : Antioxidants

[+]

Coenzyme Q10 protects against statin-induced myotoxicity in zebrafish larvae.Mar 31, 2017

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Pubmed Data : Environ Toxicol Pharmacol. 2017 Apr 1 ;52:150-160. Epub 2017 Apr 1. PMID: 28414942

Article Published Date : Mar 31, 2017

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Statin-Induced Pathologies

[+]

Coenzyme Q10 protects against the acute sequelae of myocardial infarction by profoundly reducing the infarct area, inflammation and oxidative stress.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Physiol Pathophysiol Pharmacol. 2015 ;7(1):1-13. Epub 2015 Mar 20. PMID: 26069524

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Heart Attack: Recovery, Myocardial Infarction

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective

Additional Keywords : Risk Reduction

[+]

Coenzyme Q10 protects against β-cell toxicity induced by pravastatin treatment of hypercholesterolemia.Jun 30, 2019

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Pubmed Data : J Cell Physiol. 2019 Jul ;234(7):11047-11059. Epub 2018 Dec 7. PMID: 30536661

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Physiol. 2020 ;11:64. Epub 2020 Feb 7. PMID: 32116774

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Kidney Damage: Chemically-Induced, Lead Poisoning

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Renoprotective

Problem Substances : Lead

[+]

Coenzyme Q10 regulates antioxidative stress and autophagy in acute myocardial ischemia-reperfusion injury.Dec 31, 2016

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CoQ10 ameliorates mitochondrial dysfunction in diabetic nephropathy through mitophagy.Dec 31, 2018

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Pubmed Data : J Endocrinol. 2019 Jan 1. Epub 2019 Jan 1. PMID: 30620716

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Diabetic Nephropathy, Mitochondrial Dysfunction

Pharmacological Actions : Antioxidants, Nrf2 activation

[+]

CoQ10 ameliorates monosodium glutamate-induced alteration in detrusor activity and responsiveness in rats.Oct 27, 2019

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Pubmed Data : BMC Urol. 2019 Oct 28 ;19(1):103. Epub 2019 Oct 28. PMID: 31660941

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Pubmed Data : J Cardiovasc Pharmacol. 2015 Sep 14. Epub 2015 Sep 14. PMID: 26371950

Article Published Date : Sep 13, 2015

Study Type : Animal Study

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Substances : Coenzyme Q10

Diseases : Brain Ischemia

Pharmacological Actions : Neuroprotective Agents

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CoQ10 may be a therapeutic candidate for antifibrotic methods.Dec 31, 2018

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Pubmed Data : Toxicol Sci. 2021 Dec 28 ;185(1):19-27. PMID: 34668565

Article Published Date : Dec 27, 2021

Study Type : Animal Study

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Substances : Coenzyme Q10

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Additional Keywords : Liver Regeneration

Problem Substances : Acetaminophen, Paracetamol

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CoQ10 reduces corneal damages after UVB exposure in vivo and in vitro by preserving mitochondrial function.Oct 08, 2014

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Pubmed Data : Invest Ophthalmol Vis Sci. 2014 Oct 9 ;55(11):7266-71. Epub 2014 Oct 9. PMID: 25301877

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Pubmed Data : Food Nutr Res. 2016 ;60:28127. Epub 2016 Mar 3. PMID: 26945230

Article Published Date : Dec 31, 2015

Study Type : Animal Study

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Substances : Coenzyme Q10, Melatonin

Diseases : Autism

Additional Keywords : Gut-brain Axis

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Mitochondrial parameters including, SDA, ATP levels, MMP and MPP were reduced with statin treatment and improved by co-administration with CoQ10.May 21, 2015

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Pubmed Data : Eur J Pharmacol. 2015 May 22 ;762:270-274. Epub 2015 May 22. PMID: 26007644

Article Published Date : May 21, 2015

Study Type : Animal Study

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Substances : Coenzyme Q10

Diseases : Drug-Induced Nutrient Depletion: Statin Drugs

Pharmacological Actions : Hepatoprotective

Additional Keywords : Supplementation

Problem Substances : Statin Drugs

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Modulation of antioxidant potential with coenzyme Q10 suppressed invasion of temozolomide-resistant glioma. Dec 31, 2018

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Pubmed Data : Front Cell Neurosci. 2019 ;13:74. Epub 2019 Mar 19. PMID: 30983970

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Coenzyme Q10

Diseases : Cerebral Ischemia, Cognitive Decline/Dysfunction

Therapeutic Actions : Laser Treatment: Low-Level

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Possible antioxidant mechanism of coenzyme Q10 in diabetes.Nov 30, 2019

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Pubmed Data : Res Pharm Sci. 2019 Dec ;14(6):524-533. Epub 2019 Dec 11. PMID: 32038732

Article Published Date : Nov 30, 2019

Study Type : Animal Study

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Substances : Coenzyme Q10

Diseases : Diabetes: Oxidative Stress

Pharmacological Actions : Antioxidants, Nrf2 activation, SIRT1 Activator

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Potential protective effect of coenzyme Q10 on doxorubicin-induced neurotoxicity and behavioral disturbances.Jan 02, 2022

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Pubmed Data : Neurochem Res. 2022 Jan 3. Epub 2022 Jan 3. PMID: 34978671

Article Published Date : Jan 02, 2022

Study Type : Animal Study

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Substances : Coenzyme Q10

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Chemoprotective Agents, Neuroprotective Agents

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Pubmed Data : Eur Arch Otorhinolaryngol. 2018 Oct ;275(10):2495-2505. Epub 2018 Aug 23. PMID: 30159729

Article Published Date : Sep 30, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine, Coenzyme Q10

Diseases : Allergic Rhinitis

Pharmacological Actions : interleukin-13 down-regulation, Interleukin-4 downregulation, Malondialdehyde Down-regulation, Nitric Oxide Inhibitor

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Pubmed Data : Mol Biol Rep. 2021 Apr ;48(4):3107-3115. Epub 2021 Apr 15. PMID: 33856607

Article Published Date : Mar 31, 2021

Study Type : Animal Study

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Pubmed Data : Exp Clin Transplant. 2012 Nov 28. Epub 2012 Nov 28. PMID: 23194328

Pubmed Data : Arterioscler Thromb Vasc Biol. 2017 Oct ;37(10):1923-1932. Epub 2017 Jul 6. PMID: 28684614

Article Published Date : Sep 30, 2017

Study Type : Animal Study

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Substances : Ubiquinol

Diseases : Antiphospholipid Syndrome, Endothelial Dysfunction, Inflammation

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This study provided new evidence supporting beneficial effects of coenzyme Q10 and L-carnitine on statin-induced pancreatic toxicity.Nov 30, 2017

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Pubmed Data : Res Pharm Sci. 2017 Dec ;12(6):434-443. PMID: 29204172

Article Published Date : Nov 30, 2017

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10, L-Carnitine

Diseases : Statin-Induced Pathologies

Pharmacological Actions : Pancreato Protective Agents

Problem Substances : Statin Drugs

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Topical CoQ10 appears an effective therapy preventing retinal ganglion cell apoptosis and loss in glaucoma-related models.May 23, 2017

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Pubmed Data : Pharmacol Rep. 2016 Oct ;68(5):1015-9. Epub 2016 Jul 17. PMID: 27428763

Article Published Date : Sep 30, 2016

Study Type : Review

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Substances : Coenzyme Q10

Diseases : Heart Failure

Pharmacological Actions : Cardioprotective

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Coenzyme Q10 acts as sensitizer for cytotoxic therapies.May 17, 2018

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Pubmed Data : Radiother Oncol. 2018 May 18. Epub 2018 May 18. PMID: 29784452

Article Published Date : May 17, 2018

Study Type : In Vitro Study

Additional Links

Substances : Coenzyme Q10

Diseases : Glioblastoma

Pharmacological Actions : Chemosensitizer, Radiosensitizer

Additional Keywords : Chemotherapeutic Synergy: Temozolomide

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Coenzyme Q10 alleviates chronic nucleoside reverse transcriptase inhibitor-induced premature endothelial senescence.Apr 23, 2019

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Pubmed Data : Cardiovasc Toxicol. 2019 Apr 24. Epub 2019 Apr 24. PMID: 31020509

Article Published Date : Apr 23, 2019

Study Type : In Vitro Study

Additional Links

Substances : Coenzyme Q10

Diseases : Endothelial Dysfunction, HIV Drug-Induced Toxicity

Pharmacological Actions : Cardioprotective

[+]

Coenzyme Q10 alleviates tacrolimus-induced mitochondrial dysfunction in kidney.Aug 19, 2019

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Pubmed Data : FASEB J. 2019 Aug 20:fj201900386RR. Epub 2019 Aug 20. PMID: 31431058

Article Published Date : Aug 19, 2019

Study Type : In Vitro Study

Additional Links

Substances : Coenzyme Q10

Diseases : Kidney Damage: Drug-Induced, Mitochondrial Dysfunction

Pharmacological Actions : Renoprotective

Problem Substances : Tacrolimus

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View the Evidence: 348 Abstracts with Coenzyme Q10 Research

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Coenzyme Q10 at low dose improves glucose and HbA1c levels.Jan 31, 2017

Coenzyme Q10 could have significant inflammatory lowering effects.Feb 04, 2017

Coenzyme Q10 supplementation may partly improve the process of inflammatory state.Dec 31, 2016

Coenzyme Q10 supplementation may reduce the frequency of migraine attacks per month.Feb 05, 2019

CoQ(10) may improve the ejection fraction in patients with congestive heart failure.Dec 04, 2012

CoQ10 supplementation reduced some of the important markers of inflammation and MMPs in patients with breast cancer.May 31, 2021

Patients with heart failure who used coenzyme Q10 had lower mortality and a higher exercise capacity improvement than the placebo.Jul 23, 2017

The effect of coenzyme Q10 supplementation on oxidative stress.Mar 31, 2020

This suggests that CQ10 supplementation likely attenuates subclinical inflammation.Aug 24, 2017

A 14-day coenzyme Q10 supplementation is more effective than the acute supplementation to overcome the exercise induced adverse responses.Dec 31, 2014

A combination of acetyl-l-carnitine, n-3 fatty acids and coenzyme q10 improves visual functions in early age-related macular degeneraiton.May 01, 2005

A combination of carnitine, CoQ10 and taurine repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction.Apr 01, 2009

A combination of coenzyme Q10, riboflavin and niacin may improve outcome in women with breast cancer undergoing tamoxifen therapy. Oct 01, 2009

A combination of coenzyme10, vitamin E, selenium, methionine and phospholipids protects against occupational and environmental stress in workers of the gas and oil industry. Jan 01, 2003

A pilot clinical study of liquid ubiquinol supplementation on cardiac function in pediatric dilated cardiomyopathy.Nov 06, 2018

Adjuvant CoQ10 to a standard medication improved symptoms of depression after 8 weeks of treatment.Sep 30, 2018

Administration of coenzyme Q10 in patients with impaired glucose tolerance may slow the progression from pre-diabetes to overt diabetes.Dec 31, 2017

After 3 months of treatment with the supplement, a reduction of migraine pain and burden of disease was seen.Dec 31, 2014

After a six-month administration of coenzyme Q10, muscle pain and sensitivity statistically significantly decreased.Nov 27, 2012

AGE+CoQ10 are associated with beneficial effects on inflammatory markers and reduced progression of coronary atherosclerosis.Jun 30, 2012

Aged garlic extract and coenzyme Q10 have a beneficial effect on vascular elasticity and endothelial function in firefighters with high occupational stress. Jul 31, 2012

An antioxidant formula increases important fat-soluble nutrients and antioxidants and reduces airway inflammation in patients with Cystic Fibrosis. Jan 01, 2008

Antioxidants decreases the intensification of low density lipoprotein in vivo peroxidation during therapy with statins.Jul 01, 2003

Atorvastatin worsens left ventricular diastolic function, which is improved through coenzyme q10 supplementation. Nov 15, 2004

Beneficial effect of ubiquinol on hematological and inflammatory signaling during exercise.Feb 05, 2020

Co-enzyme Q10 supplementation can be proposed as a potential candidate in patients with long-term hypertension and can play a role in erectile dysfunction.Aug 31, 2021

Coenzyme Q(10) may have therapeutic value treating male infertilitySep 01, 2011

Coenzyme Q(10), vitamin E, selenium, and methionine in the treatment of chronic recurrent viral mucocutaneous infections.Nov 11, 2011

Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21.Dec 01, 2007

Coenzyme Q10 add-on metformin therapy improves endothelial dysfunction and inflammatory changes in patients with T2DM.Sep 30, 2019

Coenzyme Q10 and L-carnitine supplements have beneficial effects on serum levels of lactate and migraine symptoms.Jan 05, 2019

Coenzyme Q10 and vitamin E had beneficial effects on cardiometabolic outcomes among women with polycystic ovary syndrome.Jan 31, 2019

Coenzyme Q10 appears to be a safe and effective migraine preventive.Mar 01, 2002

Coenzyme q10 appears to prevent tachycardia in heart failure patientsJan 01, 2008

Coenzyme Q10 appears to slow the progressive deterioration of function in Parkinson disease. Oct 01, 2002

Coenzyme Q10 as an adjuvant in conventional therapy for heart failure reduces hospitalization and incidence of serious complications. Jan 01, 1993

Coenzyme Q10 can be used as a potential intervention for diminishing the disease severity and blood pressure in Ulcerative colitis patients.Dec 31, 2020

Coenzyme Q10 enrichment decreases oxidative DNA damage in human lymphocytes.Nov 01, 2007

Coenzyme Q10 has a beneficial effect as an antioxidant in beta-thalassemia/Hb E patients.Jan 01, 2005

Coenzyme Q10 has a corrective effect on statin-induced lowering of plasma coenzyme Q10 levels.Dec 01, 2007

Coenzyme Q10 has therapeutic value in the treatment of maternally inherited diabetes mellitus and deafness.May 01, 1998

Coenzyme Q10 improves ejection fraction as an adjunctive therapy for congestive heart failure. Oct 30, 2009

Coenzyme Q10 improves endothelial function in patients with ischaemic heart disease. Aug 01, 2008

Coenzyme Q10 improves sperm kinetic features in patients with idiopathic asthenozoospermia.Jul 01, 2009

Coenzyme Q10 improves subjective fatigue sensations and physical performance during fatigue-inducing workload. Apr 01, 2008

Coenzyme Q10 improves the in vitro maturation of oocytes exposed to the intrafollicular environment of patients on fertility treatment.Mar 22, 2020

Coenzyme Q10 improves the survival and reduces inflammatory markers in septic patients.Dec 31, 2019

Coenzyme Q10 in the treatment of attention deficit hyperactivity disorder in children.Nov 22, 2021

Coenzyme Q10 levels are low in children with cystic fibrosis, indicating that supplementation could be beneficial. Apr 01, 2002

Coenzyme Q10 levels as high as 3,000 mg a day are safe and well-tolerated in ALS patients. Dec 13, 2005

Coenzyme Q10 may be beneficial in patients with high risk of atherothrombosis in patients who have had a heart attack. Apr 01, 2003

Coenzyme Q10 may be of benefit in patients with fibromyalgia. May 01, 2009

Coenzyme Q10 may be of clinical benefit in a subset of myelodysplastic syndromes. Jan 01, 2007

Coenzyme Q10 may contribute to the pathophysiology of Parkinson's disease. Dec 05, 2008

Coenzyme Q10 may decrease the symptoms of tinnitus in patients with low plasma Coenzyme Q10 levels. Jan 01, 2007

Coenzyme Q10 may provide a new complementary approach for rheumatoid arthritis patients.Aug 06, 2019

Coenzyme Q10 might be considered a safe and effective strategy for treatment of patients with bipolar disorder during their depressive phase.Jul 24, 2019

Coenzyme Q10 might have a role as a good supplement in young children with Down syndrome to ameliorate the neurological symptoms.Oct 18, 2016

Coenzyme Q10 redox state predicts the concentration of c-reactive protein.Feb 22, 2016

Coenzyme Q10 reduced the incidence of fatal and non-fatal myocardial infarctions.Feb 03, 2021

Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction.Aug 06, 2019

Coenzyme Q10 supplementation could be effective in ameliorating inflammatory cytokine levels caused by breast cancer.Dec 31, 2018

Coenzyme Q10 supplementation during pregnancy reduces the risk of prre-eclampsia. Apr 01, 2009

Coenzyme Q10 supplementation improved semen parameters and antioxidant status in men with idiopathic oligoasthenoteratospermia.Aug 13, 2019

Coenzyme Q10 supplementation improves salivary secretion associated with dry mouth.Mar 22, 2011

Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease.May 08, 2003

Coenzyme Q10 supplementation reduces oxidative stress and decreases antioxidant enzyme activity in children with autism spectrum disorders.Apr 03, 2018

Coenzyme Q10 supplementation reduces peripheral oxidative stress and inflammation in interferon-β1a-treated multiple sclerosis.Dec 31, 2018

Coenzyme supplementation may reduce oxidative stress in type 2 diabetics.Mar 31, 2015

CoenzymeQ10 as adjuvant treatment in patients with heart failure may attenuate the incidence of atrial fibrillation.May 31, 2015

CoQ10 and vitamin E supplementation had beneficial effects on serum FBS and insulin levels as well as HOMA-IR and total testosterone levels.Sep 06, 2018

CoQ10 intake for 12 weeks in PCOS women significantly improved gene expression of LDLR, PPAR-γ, IL-1, IL-8 and TNF-α.Sep 25, 2017

Coenzyme Q10

View the Evidence:
348 Abstracts with Coenzyme Q10 Research