Cornus officinalis

Name	AC	CK
Overactive Bladder	1	10
Oxidative Stress	4	7
Alzheimer's Disease	4	6
Hyperuricemia	3	6
Inflammation	3	5
Lipopolysaccharide-Induced Toxicity	3	5
Anaphylaxis	1	3
Coronavirus Disease (Covid-19)	1	3
Diabetic Nephropathy	2	3
Lung Damage	1	3
Nonalcoholic fatty liver disease (NAFLD)	2	3
Aging	1	2
Air Pollution Linked Toxicity	1	2
Encephalomyelitis	1	2
Erectile Dysfunction	1	2
Hepatitis	1	2
Liver Steatosis	1	2
Multiple Sclerosis	1	2
Myocardial Ischemia	1	2
Sepsis	1	2
Stroke: Ischemic	1	2
Chemically-Induced Liver Damage	1	1
Cognitive Decline/Dysfunction	1	1
Gestational Diabetes	1	1
Hearing Loss	1	1
Insulin Resistance	1	1
Lipid Peroxidation	1	1
Lung Injury: Acute	1	1
Psoriasis	1	1

Name	AC	CK
Anti-Inflammatory Agents	18	30
NF-kappaB Inhibitor	8	13
Interleukin-6 Downregulation	7	12
Tumor Necrosis Factor (TNF) Alpha Inhibitor	6	10
Interleukin-1 beta downregulation	4	7
Renoprotective	3	6
Antioxidants	4	5
Anti-Apoptotic	2	4
Cyclooxygenase 2 Inhibitors	3	4
Uricosuric Agents	2	4
Anti-Allergic Agents	1	3
Interleukin-17 downregulation	2	3
Neuroprotective Agents	2	3
Cardioprotective	1	2
Gastrointestinal Agents	1	2
Hypolipidemic	1	2
Immunosuppressive Agents	1	2
Interleukin-23 Downregulation	1	2
Nrf2 activation	2	2
Superoxide Dismutase Up-regulation	1	2
uric acid	1	2
Nitric Oxide Inhibitor	1	1

[+]

The Japanese multi-herbal formual known as gosha-jinki-gan could be a safe and effective potential therapeutic alternative in females with overactive bladder.Feb 01, 2008

Click here to read the entire abstract

Pubmed Data : Hinyokika Kiyo. 2008 Feb;54(2):95-9. PMID: 18323165

Article Published Date : Feb 01, 2008

Study Type : Human Study

Additional Links

Substances : Achyranthes, Alisma , Cinnamon, Cornus officinalis, Dioscorea opposita, Japanese traditional herbal formula: gosha-jinki-gan, Peony, Plantain, Rehmannia, Wolfiporia extensa

Diseases : Overactive Bladder

[+]

Cornus officinalis loganin attenuates acute lung injury in mice via regulating the PI3K/AKT/NLRP3 axis.Jul 23, 2025

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2025 Jul 24 ;351:120104. Epub 2025 Jun 7. PMID: 40490233

Article Published Date : Jul 23, 2025

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cornus officinalis

Diseases : Coronavirus Disease (Covid-19), Lipopolysaccharide-Induced Toxicity, Lung Damage

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Plant Extracts

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Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways.Apr 28, 2016

Click here to read the entire abstract

Pubmed Data : Biochem Biophys Res Commun. 2016 Apr 29 ;473(2):408-14. Epub 2016 Mar 10. PMID: 26972254

Article Published Date : Apr 28, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cornus officinalis

Diseases : Anaphylaxis

Pharmacological Actions : Anti-Allergic Agents, Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Anti-septic functions of cornuside against HMGB1-mediated severe inflammatory responses.Feb 12, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2022 Feb 13 ;23(4). Epub 2022 Feb 13. PMID: 35216180

Article Published Date : Feb 12, 2022

Study Type : Animal Study

Additional Links

Substances : Cornus officinalis

Diseases : Inflammation, Sepsis

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Antihyperuricemic effects of Cornus officinalis extract.Oct 13, 2025

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2025 Oct 14 ;26(20). Epub 2025 Oct 14. PMID: 41155274

Article Published Date : Oct 13, 2025

Study Type : Animal Study

Additional Links

Substances : Cornus officinalis

Diseases : Hyperuricemia

Pharmacological Actions : Renoprotective, uric acid

Additional Keywords : Plant Extracts

[+]

Cornus officinalis extract ameliorates fructose-induced hepatic steatosis.May 31, 2025

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Sci Nutr. 2025 Jun ;13(6):e70425. Epub 2025 Jun 11. PMID: 40501499

Article Published Date : May 31, 2025

Study Type : Animal Study

Additional Links

Substances : Cornus officinalis

Diseases : Liver Steatosis, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Gastrointestinal Agents, Hypolipidemic

[+]

Cornus officinalis total glycosides protects against myocardial I/R injury.Feb 28, 2026

Click here to read the entire abstract

Pubmed Data : Cell Signal. 2026 Mar ;139:112346. Epub 2025 Dec 26. PMID: 41456630

Article Published Date : Feb 28, 2026

Study Type : Animal Study

Additional Links

Substances : Cornus officinalis

Diseases : Inflammation, Myocardial Ischemia

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

[+]

Cornuside alleviates experimental autoimmune encephalomyelitis.May 14, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Zhejiang Univ Sci B. 2021 May 15 ;22(5):421-430. PMID: 33973423

Article Published Date : May 14, 2021

Study Type : Animal Study

Additional Links

Substances : Cornus officinalis

Diseases : Encephalomyelitis, Multiple Sclerosis

Pharmacological Actions : Anti-Inflammatory Agents, Immunosuppressive Agents, Interleukin-17 downregulation, Interleukin-23 Downregulation, Interleukin-6 Downregulation

[+]

Cornuside ameliorates cognitive impairments in scopolamine induced AD mice.Jul 14, 2022

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2022 Jul 15 ;293:115252. Epub 2022 Apr 9. PMID: 35405255

Article Published Date : Jul 14, 2022

Study Type : Animal Study

Additional Links

Substances : Cornus officinalis

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation

[+]

Cornuside ameliorates cognitive impairments via RAGE/TXNIP/NF-κB signaling in Aβ1-42 induced Alzheimer's disease mice.May 22, 2024

Click here to read the entire abstract

Pubmed Data : J Neuroimmune Pharmacol. 2024 May 23 ;19(1):24. Epub 2024 May 23. PMID: 38780885

Article Published Date : May 22, 2024

Study Type : Animal Study

Additional Links

Substances : Cornus officinalis

Diseases : Alzheimer's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Cornuside as a promising therapeutic agent for diabetic kidney disease.Mar 05, 2025

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2025 Mar 6 ;149:114190. Epub 2025 Feb 3. PMID: 39904045

Article Published Date : Mar 05, 2025

Study Type : Animal Study

Additional Links

Substances : Cornus officinalis

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Apoptotic, Renoprotective

[+]

Cornuside improves murine autoimmune hepatitis through inhibition of inflammatory responses.Oct 31, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Phytomedicine. 2023 Nov ;120:155077. Epub 2023 Sep 9. PMID: 37716032

Article Published Date : Oct 31, 2023

Study Type : Animal Study

Additional Links

Substances : Cornus officinalis

Diseases : Hepatitis

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Cornuside protects against ischemic stroke.Feb 29, 2024

Click here to read the entire abstract

Pubmed Data : Exp Neurol. 2024 Mar ;373:114672. Epub 2023 Dec 31. PMID: 38169196

Article Published Date : Feb 29, 2024

Study Type : Animal Study

Additional Links

Substances : Cornus officinalis

Diseases : Stroke: Ischemic

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor

[+]

Cornuside, by regulating the AGEs-RAGE-IκBα-ERK1/2 signaling pathway, ameliorates cognitive impairment associated with brain aging.May 31, 2023

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2023 Jun ;37(6):2419-2436. Epub 2023 Feb 13. PMID: 36781177

Article Published Date : May 31, 2023

Study Type : Animal Study

Additional Links

Substances : Cornus officinalis

Diseases : Aging, Alzheimer's Disease, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Hypouricemic effects of Chrysanthemum indicum L. and Cornus officinalis on hyperuricemia-induced HepG2 Cells, renal cells.Aug 12, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Plants (Basel). 2021 Aug 13 ;10(8). Epub 2021 Aug 13. PMID: 34451714

Article Published Date : Aug 12, 2021

Study Type : Animal Study

Additional Links

Substances : Chrysanthemum Indicum, Cornus officinalis

Diseases : Hyperuricemia

Pharmacological Actions : Uricosuric Agents

[+]

The renoprotective anti-hyperuricemia effect of Cornus officinalis extract in hyperuricemia rats based on network pharmacology and multiple omics.Jan 09, 2026

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2026 Jan 10 ;354:120519. Epub 2025 Sep 4. PMID: 40914308

Article Published Date : Jan 09, 2026

Study Type : Animal Study

Additional Links

Substances : Cornus officinalis

Diseases : Hyperuricemia, Oxidative Stress

Pharmacological Actions : Renoprotective, Uricosuric Agents

Additional Keywords : Plant Extracts

[+]

Therapeutic effects of cornuside on particulate matter-induced lung injury.Mar 03, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2023 Mar 4 ;24(5). Epub 2023 Mar 4. PMID: 36902409

Article Published Date : Mar 03, 2023

Study Type : Animal Study

Additional Links

Substances : Cornus officinalis

Diseases : Air Pollution Linked Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Tribulus terrestris and Cornus officinalis may have value in treating penile erection dysfunction.Sep 30, 2012

Click here to read the entire abstract

Pubmed Data : J Sex Med. 2012 Oct ;9(10):2544-51. Epub 2012 Aug 20. PMID: 22906304

Article Published Date : Sep 30, 2012

Study Type : Animal Study

Additional Links

Substances : Cornus officinalis, Tribulus

Diseases : Erectile Dysfunction

[+]

Cornuside alleviates cognitive impairments induced by Aβ1-42 through attenuating NLRP3-mediated neurotoxicity by promoting mitophagy.Feb 18, 2025

Click here to read the entire abstract

Pubmed Data : Alzheimers Res Ther. 2025 Feb 19 ;17(1):47. Epub 2025 Feb 19. PMID: 39972387

Article Published Date : Feb 18, 2025

Study Type : In Vitro Study

Additional Links

Substances : Cornus officinalis

Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

[+]

Cornuside alleviates psoriasis-like skin lesions in mice by relieving inflammatory effects.Jun 14, 2024

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2024 Jun 15 ;134:112183. Epub 2024 May 4. PMID: 38705031

Article Published Date : Jun 14, 2024

Study Type : In Vitro Study

Additional Links

Substances : Cornus officinalis

Diseases : Psoriasis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation

[+]

Cornuside ameliorates LPS induced cognitive dysfunction and microglial NLRP3 inflammasome activation by enhancing Sirt1-mediated autophagy.Jan 29, 2026

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2026 Jan 30 ;355(Pt A):120615. Epub 2025 Sep 15. PMID: 40962125

Article Published Date : Jan 29, 2026

Study Type : In Vitro Study

Additional Links

Substances : Cornus officinalis

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Cornuside inhibits glucose-induced proliferation and inflammatory response of mesangial cells.Oct 31, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Korean J Physiol Pharmacol. 2023 Nov 1 ;27(6):513-520. PMID: 37884283

Article Published Date : Oct 31, 2023

Study Type : In Vitro Study

Additional Links

Substances : Cornus officinalis

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

[+]

Cornuside is a potential agent against Alzheimer's disease.Aug 02, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Aug 3 ;14(15). Epub 2022 Aug 3. PMID: 35956355

Article Published Date : Aug 02, 2022

Study Type : In Vitro Study

Additional Links

Substances : Cornus officinalis

Diseases : Alzheimer's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Cornuside mitigates acute lung injury.Dec 31, 2024

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2025 ;16:1682523. Epub 2025 Oct 8. PMID: 41132524

Article Published Date : Dec 31, 2024

Study Type : In Vitro Study

Additional Links

Substances : Cornus officinalis

Diseases : Lung Injury: Acute

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation

[+]

Cornuside suppresses lipopolysaccharide-induced inflammatory mediators by inhibiting nuclear factor-kappa B activation in RAW 264.7 macrophages.Dec 31, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biol Pharm Bull. 2011 ;34(7):959-66. PMID: 21719998

Article Published Date : Dec 31, 2010

Study Type : In Vitro Study

Additional Links

Substances : Cornus officinalis

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

Iridoid glycoside cornuside alleviates the symptom of gestational diabetes mellitus.Dec 31, 2023

Click here to read the entire abstract

Pubmed Data : Gynecol Obstet Invest. 2024 ;89(1):59-68. Epub 2023 Nov 18. PMID: 37980893

Article Published Date : Dec 31, 2023

Study Type : In Vitro Study

Additional Links

Substances : Cornus officinalis

Diseases : Gestational Diabetes, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Multiscale insights into cornuside's effects on NAFLD.Jun 30, 2025

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2025 Jul ;142:156809. Epub 2025 Apr 26. PMID: 40344848

Article Published Date : Jun 30, 2025

Study Type : In Vitro Study

Additional Links

Substances : Cornus officinalis

Diseases : Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Protective effect of cornuside against carbon tetrachloride-induced acute hepatic injury.Dec 31, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biosci Biotechnol Biochem. 2011 ;75(4):656-61. Epub 2011 Apr 22. PMID: 21512227

Article Published Date : Dec 31, 2010

Study Type : In Vitro Study

Additional Links

Substances : Cornus officinalis

Diseases : Chemically-Induced Liver Damage, Lipid Peroxidation

Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Ursolic acid from Cornus officinalis prevents hydrogen peroxide induced damage to auditory cells.Jan 01, 2009

Click here to read the entire abstract

Pubmed Data : Am J Chin Med. 2009;37(4):735-46. PMID: 19655411

Article Published Date : Jan 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Cornus officinalis, Ursolic Acid

Diseases : Hearing Loss, Oxidative Stress

Additional Keywords : Plant Extracts

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View the Evidence: 29 Abstracts with Cornus officinalis Research

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The Japanese multi-herbal formual known as gosha-jinki-gan could be a safe and effective potential therapeutic alternative in females with overactive bladder.Feb 01, 2008

Cornus officinalis loganin attenuates acute lung injury in mice via regulating the PI3K/AKT/NLRP3 axis.Jul 23, 2025

Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways.Apr 28, 2016

Anti-septic functions of cornuside against HMGB1-mediated severe inflammatory responses.Feb 12, 2022

Antihyperuricemic effects of Cornus officinalis extract.Oct 13, 2025

Cornus officinalis extract ameliorates fructose-induced hepatic steatosis.May 31, 2025

Cornus officinalis total glycosides protects against myocardial I/R injury.Feb 28, 2026

Cornuside alleviates experimental autoimmune encephalomyelitis.May 14, 2021

Cornuside ameliorates cognitive impairments in scopolamine induced AD mice.Jul 14, 2022

Cornuside ameliorates cognitive impairments via RAGE/TXNIP/NF-κB signaling in Aβ1-42 induced Alzheimer's disease mice.May 22, 2024

Cornuside as a promising therapeutic agent for diabetic kidney disease.Mar 05, 2025

Cornuside improves murine autoimmune hepatitis through inhibition of inflammatory responses.Oct 31, 2023

Cornuside protects against ischemic stroke.Feb 29, 2024

Cornuside, by regulating the AGEs-RAGE-IκBα-ERK1/2 signaling pathway, ameliorates cognitive impairment associated with brain aging.May 31, 2023

Hypouricemic effects of Chrysanthemum indicum L. and Cornus officinalis on hyperuricemia-induced HepG2 Cells, renal cells.Aug 12, 2021

The renoprotective anti-hyperuricemia effect of Cornus officinalis extract in hyperuricemia rats based on network pharmacology and multiple omics.Jan 09, 2026

Therapeutic effects of cornuside on particulate matter-induced lung injury.Mar 03, 2023

Tribulus terrestris and Cornus officinalis may have value in treating penile erection dysfunction.Sep 30, 2012

Cornuside alleviates cognitive impairments induced by Aβ1-42 through attenuating NLRP3-mediated neurotoxicity by promoting mitophagy.Feb 18, 2025

Cornuside alleviates psoriasis-like skin lesions in mice by relieving inflammatory effects.Jun 14, 2024

Cornuside ameliorates LPS induced cognitive dysfunction and microglial NLRP3 inflammasome activation by enhancing Sirt1-mediated autophagy.Jan 29, 2026

Cornuside inhibits glucose-induced proliferation and inflammatory response of mesangial cells.Oct 31, 2023

Cornuside is a potential agent against Alzheimer's disease.Aug 02, 2022

Cornuside mitigates acute lung injury.Dec 31, 2024

Cornuside suppresses lipopolysaccharide-induced inflammatory mediators by inhibiting nuclear factor-kappa B activation in RAW 264.7 macrophages.Dec 31, 2010

Iridoid glycoside cornuside alleviates the symptom of gestational diabetes mellitus.Dec 31, 2023

Multiscale insights into cornuside's effects on NAFLD.Jun 30, 2025

Protective effect of cornuside against carbon tetrachloride-induced acute hepatic injury.Dec 31, 2010

Ursolic acid from Cornus officinalis prevents hydrogen peroxide induced damage to auditory cells.Jan 01, 2009

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Cornus officinalis

View the Evidence:
29 Abstracts with Cornus officinalis Research