Crocetin

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86 Diseases Researched for Crocetin
NameACCKFocus
Oxidative Stress815Locked
Atherosclerosis314Locked
Myopia314Locked
Glaucoma212Locked
Sleep Disorders212Locked
Coronary Artery Disease110Locked
Breast Cancer67Locked
Chemotherapy-Induced Toxicity: Arsenic Trioxide27Locked
Depression36Locked
Alzheimer's Disease35Locked
Nonalcoholic fatty liver disease (NAFLD)35Locked
Cancers: All44Locked
Cardiac Hypertrophy24Locked
Cervical Cancer34Locked
Inflammation34Locked
Ischemia24Locked
Myocardial Ischemia24Locked
Breast Cancer: Triple Negative 23Locked
Cardiovascular Diseases23Locked
Coronavirus Infection23Locked
Esophageal Cancer33Locked
Hypertension23Locked
Leukemia: Acute promyelocytic leukemia 23Locked
Lipopolysaccharide-Induced Toxicity23Locked
Macular Degeneration23Locked
Radiation23Locked
Acute Respiratory Distress Syndrome12Locked
Anxiety12Locked
Arsenic Poisoning12Locked
Arthritis12Locked
Brain Inflammation 12Locked
Breast Cancer: Chemically-Induced12Locked
Burns12Locked
Cardiomegaly12Locked
Cerebral Ischemia12Locked
Chemically-Induced Liver Damage12Locked
Chronic Pain12Locked
Cognitive Decline/Dysfunction12Locked
Delayed Sleep Phase Disorder12Locked
Dengue12Locked
Diabetes Mellitus: Type 212Locked
Diabetic Nephropathy12Locked
Dyslipidemias12Locked
Fulminant Hepatic Failure12Locked
Gastrointestinal Inflammation12Locked
Gestational Diabetes12Locked
Glioblastoma12Locked
Heart Failure12Locked
Hydrogen Peroxide Induced Toxicity22Locked
Insomnia12Locked
Intestinal Injury12Locked
Kidney Damage: Chemically-Induced12Locked
Liver Damage12Locked
Liver Injury: Ischemia/reperfusion 12Locked
Lung Cancer22Locked
Menopausal Syndrome12Locked
Metabolic Diseases12Locked
Myocardial Infarction12Locked
Ovarian Cancer22Locked
Parkinson's Disease12Locked
Polycystic Ovary Syndrome12Locked
Spinal Cord Injuries12Locked
Traumatic Brain Injury12Locked
Urinary Tract Infections12Locked
Asthma11Locked
Cancers: Drug Resistant11Locked
Cancers: Multi-Drug Resistant11Locked
Cardiovascular Disease11Locked
Chemotherapy and Radiation Toxicity11Locked
Colorectal Cancer11Locked
Diabetic Complications11Locked
Diabetic Retinopathy11Locked
Endothelial Dysfunction11Locked
Escherichia coli Infections11Locked
Eye Damage11Locked
Gastric Cancer11Locked
Hypercholesterolemia11Locked
Immune Dysregulation: TH1/TH2 imbalance11Locked
Liver Cancer11Locked
Obesity11Locked
Pseudomonas aeruginosa11Locked
Sepsis11Locked
Staphylococcus aureus infection11Locked
Staphylococcus epidermidis11Locked
Stroke: Ischemic11Locked
Ultraviolet Radiation Induced Damage11Locked
63 Pharmacological Actions Researched for Crocetin
NameACCKFocus
Antioxidants2864Locked
Anti-Inflammatory Agents2443Locked
Cardioprotective1220Locked
Neuroprotective Agents1018Locked
Interleukin-1 beta downregulation814Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor814Locked
Anti-Apoptotic512Locked
Interleukin-6 Downregulation712Locked
Antiproliferative 1011Locked
Heme oxygenase-1 up-regulation611Locked
Nrf2 activation611Locked
Anti-atherogenic110Locked
Hepatoprotective59Locked
Chemopreventive68Locked
Hypolipidemic58Locked
Apoptotic67Locked
NF-kappaB Inhibitor47Locked
Anti-metastatic56Locked
Antidepressive Agents36Locked
Chemoprotective Agents26Locked
Angiogenesis Inhibitors34Locked
Cyclooxygenase 2 Inhibitors34Locked
Prophylactic Agents24Locked
Renoprotective24Locked
Chemotherapeutic33Locked
Immunomodulatory33Locked
Malondialdehyde Down-regulation23Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor33Locked
Radioprotective23Locked
Vascular Endothelial Growth Factor Inhibitors33Locked
Vasodilator Agents23Locked
Anti-Anxiety Agents12Locked
Anticarcinogenic Agents12Locked
Antihypertensive Agents12Locked
Antinoceceptive 12Locked
Autophagy Up-regulation12Locked
Chemosensitizer22Locked
Gastrointestinal Agents12Locked
Hypoglycemic Agents12Locked
MicroRNA modulator12Locked
Neuritogenic12Locked
P21 Activation22Locked
Radiosensitizer12Locked
Transforming growth factor beta (TGF-β) inhibitor12Locked
Tumor Suppressor Protein p53 Upregulation22Locked
Anti-Bacterial Agents11Locked
Antiviral Agents11Locked
Bcl-2 protein down-regulation11Locked
Bcl-xL down-regulation11Locked
Caspase-3 Activation11Locked
Cyclin D1 Down-Regulation11Locked
Enzyme Inhibitors11Locked
Interferon Gamma Reducer11Locked
Interleukin-12 downregulation11Locked
Interleukin-8 downregulation11Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor11Locked
Multidrug Resistance Gene Modulators11Locked
Nitric Oxide Enhancer11Locked
Nitric Oxide Inhibitor11Locked
Photoprotective11Locked
STAT3 Inhibitor11Locked
Survivin Down-Regulation11Locked
Wnt/β-catenin signaling pathway modulation11Locked
Related Topics

Crocetin is a Sub of the following Topic

View the Evidence:
96 Abstracts with Crocetin Research

[+]

crocetin could be considered as a promising anti-atherogenic candidate for future studies.Oct 31, 2019

Pubmed Data : Food Funct. 2019 Nov 1 ;10(11):7461-7475. Epub 2019 Oct 31. PMID: 31667483
Article Published Date : Oct 31, 2019
Study Type : Human Study
Additional Links
Substances : Crocetin
Diseases : Atherosclerosis, Coronary Artery Disease
Pharmacological Actions : Anti-atherogenic
[+]

Crocetin may have a suppressive effect on myopia progression in children.Aug 06, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Med. 2019 Aug 7 ;8(8). Epub 2019 Aug 7. PMID: 31394821
Article Published Date : Aug 06, 2019
Study Type : Human Study
Additional Links
Substances : Crocetin
Diseases : Myopia
Pharmacological Actions : Antioxidants
[+]

The effect of dietary antioxidant supplementation in patients with glaucoma.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Ophthalmol. 2021 ;15:2293-2300. Epub 2021 Jun 2. PMID: 34113073
Article Published Date : Dec 31, 2020
Study Type : Human Study
Additional Links
Substances : Crocetin, Hesperidin, Tamarind
Diseases : Glaucoma
Pharmacological Actions : Antioxidants
[+]

The findings of the present study suggest that crocetin supplementation contributes to sleep maintenance.Nov 30, 2018

Pubmed Data : Complement Ther Med. 2018 Dec ;41:47-51. Epub 2018 Sep 8. PMID: 30477864
Article Published Date : Nov 30, 2018
Study Type : Human Study
Additional Links
Substances : Crocetin
Diseases : Sleep Disorders
[+]

Protective effects of crocetin on arsenic trioxide-induced oxidative stress.Oct 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : In Vivo. 2021 Nov-Dec;35(6):3157-3163. PMID: 34697146
Article Published Date : Oct 31, 2021
Study Type : Human In Vitro
Additional Links
Substances : Crocetin
Diseases : Chemotherapy-Induced Toxicity: Arsenic Trioxide, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Chemoprotective Agents
Problem Substances : Arsenic Trioxide
[+]

Crocetin suppresses gestational diabetes in streptozotocin-induced diabetes mellitus via suppression of inflammatory reaction.Jul 25, 2021

Pubmed Data : J Food Biochem. 2021 Jul 26:e13857. Epub 2021 Jul 26. PMID: 34309046
Article Published Date : Jul 25, 2021
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Gestational Diabetes
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Ameliorative effects and mechanism of crocetin in arsenic trioxide‑induced cardiotoxicity.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2020 Dec ;22(6):5271-5281. Epub 2020 Oct 14. PMID: 33173984
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Arsenic Poisoning, Chemotherapy-Induced Toxicity: Arsenic Trioxide, Leukemia: Acute promyelocytic leukemia
Pharmacological Actions : Cardioprotective
Problem Substances : Arsenic Trioxide
[+]

Anti-metastatic properties of a potent herbal combination in cell and mice models of triple negative breast cancer.Feb 14, 2020

Pubmed Data : Life Sci. 2020 Feb 15 ;243:117245. Epub 2020 Jan 8. PMID: 31926253
Article Published Date : Feb 14, 2020
Study Type : Animal Study
Additional Links
Substances : Crocetin, Crocin, Saffron
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

Cardio-protective and anti-atherosclerosis effect of crocetin on vitamin D3 and HFD-induced atherosclerosis.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Oleo Sci. 2021 ;70(10):1447-1459. PMID: 34615830
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Crocetin, Vitamin D
Diseases : Atherosclerosis, Cardiovascular Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Central H 2 histaminergic and alpha-2 adrenergic receptors involvement in crocetin-induced antinociception in orofacial formalin pain.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Vet Res Forum. 2020 ;11(3):229-234. Epub 2020 Sep 15. PMID: 33133459
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Chronic Pain
Pharmacological Actions : Antinoceceptive
[+]

Combined pretreatment with the extract of Nardosatchys jatamansi, crocetin and selenium led to improved behavioural outcomes.Sep 30, 2012

Pubmed Data : Neurol Sci. 2012 Oct ;33(5):1011-20. Epub 2011 Dec 15. PMID: 22170092
Article Published Date : Sep 30, 2012
Study Type : Animal Study
Additional Links
Substances : Crocetin, Selenium, Spikenard
Diseases : Cognitive Decline/Dysfunction, Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Natural Substance Synergy, Phytotherapy
[+]

Crocetin act as a possible protective agent in myocardial infarction by decreasing oxidative stress and inflammatory cytokines.Jun 22, 2017

Pubmed Data : Biomed Pharmacother. 2017 Jun 23 ;93:376-382. Epub 2017 Jun 23. PMID: 28651239
Article Published Date : Jun 22, 2017
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Myocardial Infarction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Malondialdehyde Down-regulation
Additional Keywords : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Crocetin, Malondialdehyde Down-regulation, Myocardial Infarction
Problem Substances : Isoproterenol
[+]

Crocetin alleviates inflammation in MPTP-induced Parkinson's disease models.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Parkinsons Dis. 2020 ;2020:9864370. Epub 2020 Oct 10. PMID: 33101635
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Crocetin alleviates myocardial ischemia/reperfusion injury.Jan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2020 Feb ;21(2):641-648. Epub 2019 Dec 17. PMID: 31974615
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Crocetin alleviates ovariectomy-induced metabolic dysfunction through regulating estrogen receptor β.Nov 30, 2021

Pubmed Data : J Agric Food Chem. 2021 Dec 1. Epub 2021 Dec 1. PMID: 34851635
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Menopausal Syndrome, Metabolic Diseases
Pharmacological Actions : Hypolipidemic
[+]

Crocetin ameliorates chronic restraint stress-induced depression-like behaviors.Nov 22, 2020

Pubmed Data : J Ethnopharmacol. 2020 Nov 23 ;268:113608. Epub 2020 Nov 23. PMID: 33242618
Article Published Date : Nov 22, 2020
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Gastrointestinal Agents, Neuroprotective Agents
[+]

Crocetin ameliorates non-alcoholic fatty liver disease.Nov 26, 2021

Pubmed Data : J Ethnopharmacol. 2021 Nov 27:114873. Epub 2021 Nov 27. PMID: 34848360
Article Published Date : Nov 26, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective, Hypolipidemic
[+]

Crocetin ameliorative effect on diabetic nephropathy.Nov 30, 2023

Pubmed Data : Clin Nutr ESPEN. 2023 Dec ;58:61-66. Epub 2023 Sep 9. PMID: 38057037
Article Published Date : Nov 30, 2023
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Renoprotective, Transforming growth factor beta (TGF-β) inhibitor
[+]

Crocetin and crocin are potential natural biomedicines for the management of diseases associated with abnormal blood vessel growth.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:675359. Epub 2021 Apr 30. PMID: 33995106
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Crocetin, Crocin
Diseases : Macular Degeneration
Pharmacological Actions : Angiogenesis Inhibitors
[+]

Crocetin attenuates the oxidative stress, inflammation and apoptosis in arsenic trioxide-induced nephrotoxic rats.Sep 08, 2020

Pubmed Data : Int Immunopharmacol. 2020 Sep 9 ;88:106959. Epub 2020 Sep 9. PMID: 32919218
Article Published Date : Sep 08, 2020
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Kidney Damage: Chemically-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Arsenic Trioxide
[+]

Crocetin attenuating Urinary tract Infection and adherence of uropathogenic E. coli in NRK-52E cells via an inflammatory pathway.Nov 17, 2021

Pubmed Data : J Food Biochem. 2021 Nov 18:e13998. Epub 2021 Nov 18. PMID: 34792197
Article Published Date : Nov 17, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Urinary Tract Infections
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Crocetin confers neuroprotection and is anti-inflammatory in rats with induced glaucoma.Nov 30, 2022

Pubmed Data : Mol Biol Rep. 2022 Dec 1. Epub 2022 Dec 1. PMID: 36456771
Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Glaucoma
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocetin could be used as a preventative measure against myopia progression.Jan 08, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Jan 9 ;12(1). Epub 2020 Jan 9. PMID: 31936441
Article Published Date : Jan 08, 2020
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Myopia
Pharmacological Actions : Prophylactic Agents
Additional Keywords : Risk Reduction
[+]

Crocetin exerts healthy vasomodulatory effects in hypertension, strongly improving endothelium-dependent ACH relaxations via endothelial nitric oxide but not the cyclooxygenase pathway.Dec 31, 2013

Pubmed Data : J Vasc Res. 2014 ;51(5):393-404. Epub 2014 Dec 20. PMID: 25531977
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents, Vasodilator Agents
[+]

Crocetin extracted from saffron shows antitumor effects in models of human glioblastoma.Jan 08, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 Jan 9 ;21(2). Epub 2020 Jan 9. PMID: 31936544
Article Published Date : Jan 08, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Glioblastoma
Pharmacological Actions : Apoptotic, Radiosensitizer
Additional Keywords : Natural Substances Versus Drugs, Superiority of Natural Substances versus Drugs
[+]

Crocetin has a cardioprotective effect in cardiac hypertrophy induced by norepinephrine in rats.Apr 01, 2006

Pubmed Data : Pharmazie. 2006 Apr;61(4):348-52. PMID: 16649553
Article Published Date : Apr 01, 2006
Study Type : Animal Study
Additional Links
Substances : Carotenoids, Crocetin, Saffron
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Crocetin improves amyloid-β accumulation-induced learning and memory deficit in a Alzheimer's disease model.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Immun Ageing. 2018 ;15:24. Epub 2018 Oct 30. PMID: 30450117
Article Published Date : Dec 31, 2017
Study Type : Transgenic Animal Study
Additional Links
Substances : Crocetin
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Crocetin improves dengue virus-induced liver injury.Jul 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Viruses. 2020 Jul 30 ;12(8). Epub 2020 Jul 30. PMID: 32751420
Article Published Date : Jul 29, 2020
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Dengue, Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, NF-kappaB Inhibitor
[+]

Crocetin may be used as a novel therapy for preventing fulminant hepatic failure.Oct 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2019 Nov ;18(5):3775-3782. Epub 2019 Sep 19. PMID: 31616509
Article Published Date : Oct 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Fulminant Hepatic Failure, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
[+]

Crocetin mitigates irradiation injury in an in vitro model of the pubertal testis.Mar 16, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Mar 17 ;26(6). Epub 2021 Mar 17. PMID: 33802807
Article Published Date : Mar 16, 2021
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Radiation
Pharmacological Actions : Antioxidants, Radioprotective
[+]

Crocetin preconditioning attenuates ischemia reperfusion-induced hepatic injury.May 31, 2024

Pubmed Data : Tissue Cell. 2024 Jun ;88:102411. Epub 2024 May 21. PMID: 38781791
Article Published Date : May 31, 2024
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Liver Injury: Ischemia/reperfusion , Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocetin promotes clearance of amyloid-β by inducing autophagy.Jan 18, 2021

Pubmed Data : Autophagy. 2021 Jan 19:1-20. Epub 2021 Jan 19. PMID: 33404280
Article Published Date : Jan 18, 2021
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Alzheimer's Disease, Brain Inflammation
Pharmacological Actions : Autophagy Up-regulation, Neuroprotective Agents
[+]

Crocetin promotes neurite growth and facilitates the recovery of motor and sensorimotor functions after spinal cord injury.Aug 01, 2017

Pubmed Data : Neurosci Bull. 2017 Aug 2. Epub 2017 Aug 2. PMID: 28770439
Article Published Date : Aug 01, 2017
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuritogenic
[+]

Crocetin protects against cardiac hypertrophy. May 01, 2009

Pubmed Data : J Cell Mol Med. 2009 May;13(5):909-25. Epub 2008 Dec 24. PMID: 19413885
Article Published Date : May 01, 2009
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Cardiac Hypertrophy, Cardiomegaly
Pharmacological Actions : Antioxidants, Cardioprotective, NF-kappaB Inhibitor
[+]

Crocetin protects cardiomyocytes against hypoxia/reoxygenation injury.Jan 27, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Geriatr Cardiol. 2023 Jan 28 ;20(1):68-82. PMID: 36875162
Article Published Date : Jan 27, 2023
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Myocardial Ischemia
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Crocetin protects mouse brain from apoptosis in traumatic brain injury model through activation of autophagy.Mar 02, 2024

Pubmed Data : Brain Inj. 2024 Mar 3:1-7. Epub 2024 Mar 3. PMID: 38433503
Article Published Date : Mar 02, 2024
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

Crocetin regulates functions of neural stem cells to generate new neurons for cerebral ischemia recovery.Mar 30, 2023

Pubmed Data : Adv Healthc Mater. 2023 Mar 31:e2203132. Epub 2023 Mar 31. PMID: 37001492
Article Published Date : Mar 30, 2023
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Cerebral Ischemia
Pharmacological Actions : Neuroprotective Agents
[+]

Crocetin supplementation in the MCA mice also showed protection against cervical cancer. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2015 ;2015:829513. Epub 2015 Mar 22. PMID: 25874230
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Cervical Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocetin suppresses uterine ischemia/reperfusion-induced inflammation and apoptosis through Nrf-2/HO-1 pathway.May 19, 2022

Pubmed Data : Curr Mol Med. 2022 May 20. Epub 2022 May 20. PMID: 35619323
Article Published Date : May 19, 2022
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Inflammation, Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Crocetin treatment may protect against burn-induced small intestinal injury, possibly by inhibiting burn-induced oxidative stress and inflammatory response.Jun 02, 2015

Pubmed Data : J Surg Res. 2015 Jun 3. Epub 2015 Jun 3. PMID: 26119275
Article Published Date : Jun 02, 2015
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Burns, Gastrointestinal Inflammation, Intestinal Injury, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Crocetin was an effective agent in attenuating the adjuvant-induced arthritis rats in a concentration-dependent manner.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:1341. Epub 2018 Dec 12. PMID: 30618728
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation
Additional Keywords : Dose Response
[+]

Crocin and crocetin showed a significant protective effect against the N-methyl-N-nitrosourea induced breast cancer in rats.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell J. 2017 Apr-Jun;19(1):94-101. Epub 2016 Dec 21. PMID: 28367420
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Crocetin, Crocin
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

Crocin and crocetin significantly increased the total time of non-rapid eye movement (non-REM) sleep after the administration.Jan 31, 2012

Pubmed Data : Mol Nutr Food Res. 2012 Feb ;56(2):304-8. Epub 2011 Oct 28. PMID: 22038919
Article Published Date : Jan 31, 2012
Study Type : Animal Study
Additional Links
Substances : Carotenoids, Crocetin, Crocin, Saffron
Diseases : Delayed Sleep Phase Disorder, Insomnia, Sleep Disorders
Additional Keywords : Dose Response
[+]

Identification of crocetin as a dual agonist of GPR40 and GPR120 responsible for the antidiabetic effect of saffron.Nov 12, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2023 Nov 13 ;15(22). Epub 2023 Nov 13. PMID: 38004168
Article Published Date : Nov 12, 2023
Study Type : Animal Study
Additional Links
Substances : Crocetin, Saffron
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents
[+]

Involvement of PI3K/AKT pathway in the rapid antidepressant effects of crocetin in mice with depression-like phenotypes.Jan 31, 2024

Pubmed Data : Neurochem Res. 2024 Feb ;49(2):477-491. Epub 2023 Nov 7. PMID: 37935859
Article Published Date : Jan 31, 2024
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
[+]

Liposomal encapsulation of trans-crocetin enhances oxygenation in patients with COVID-19-related ARDS receiving mechanical ventilation.Jun 23, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Control Release. 2021 Jun 24 ;336:252-261. Epub 2021 Jun 24. PMID: 34175365
Article Published Date : Jun 23, 2021
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Acute Respiratory Distress Syndrome, Coronavirus Infection
Additional Keywords : Ventilator Mortality
[+]

Preventive and therapeutic effects of crocetin in rats with heart failure. Apr 11, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2024 Apr 12 ;17(4). Epub 2024 Apr 12. PMID: 38675456
Article Published Date : Apr 11, 2024
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Heart Failure
Pharmacological Actions : Cardioprotective
[+]

Saffron carotenoids reversed the unpredictable chronic mild stress-induced depression and anxiety.Sep 30, 2023

Pubmed Data : Phytomedicine. 2023 Oct ;119:154989. Epub 2023 Jul 20. PMID: 37506574
Article Published Date : Sep 30, 2023
Study Type : Animal Study
Additional Links
Substances : Crocetin, Crocin, Saffron
Diseases : Anxiety, Depression
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
Problem Substances : Fluoxetine (trade name Prozac)
[+]

The carotenoid compound of saffron crocetin alleviates effects of ischemia reperfusion injury.Feb 12, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cureus. 2020 Feb 13 ;12(2):e6979. Epub 2020 Feb 13. PMID: 32089976
Article Published Date : Feb 12, 2020
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator
[+]

The current investigation revealed that the crocetin reduced the high cholesterol diet induced dyslipidemia.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2018 Mar ;25(3):493-499. Epub 2016 Nov 10. PMID: 29692651
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Atherosclerosis, Dyslipidemias
Pharmacological Actions : Antioxidants, Hypolipidemic
[+]

The present study provides in vivo evidence that crocetin improved the polycystic ovarian syndrome in mice.Oct 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Nov ;107:1363-1369. Epub 2018 Aug 31. PMID: 30257351
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Polycystic Ovary Syndrome
[+]

These findings suggest that crocetin ameliorates arsenic trioxide-induced hepatic injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2020 ;14:1921-1931. Epub 2020 May 19. PMID: 32546959
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Arsenic Trioxide
[+]

These results suggest that a dietary factor crocetin may have a preventive effect against myopia progression.Jan 21, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 Jan 22 ;9(1):295. Epub 2019 Jan 22. PMID: 30670743
Article Published Date : Jan 21, 2019
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Myopia
Pharmacological Actions : Prophylactic Agents
[+]

This study shows that crocetin is a potential bioactive ingredient of saffron that treats NAFLD.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Med (Lausanne). 2021 ;8:681391. Epub 2021 Jun 9. PMID: 34179049
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Crocetin, Saffron
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

A comparative study on anti-invasion, antimigration, and anti-adhesion effects of the bioactive carotenoids of saffron on 4T1 breast cancer cells.Jul 31, 2018

Pubmed Data : DNA Cell Biol. 2018 Aug ;37(8):697-707. Epub 2018 Jul 3. PMID: 29969282
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Crocetin, Crocin, Saffron
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Wnt/β-catenin signaling pathway modulation
[+]

Antibiofilm activity of carotenoid crocetin against Staphylococcal strains.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Infect Microbiol. 2024 ;14:1404960. Epub 2024 May 13. PMID: 38803574
Article Published Date : Dec 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Escherichia coli Infections, Pseudomonas aeruginosa, Staphylococcus aureus infection, Staphylococcus epidermidis
Pharmacological Actions : Anti-Bacterial Agents
[+]

Crocetin and crocin decreased cholesterol and triglyceride content of both breast cancer tumors and cell lines.Jun 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2020 Jul-Aug;10(4):384-397. PMID: 32850295
Article Published Date : Jun 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocetin, Crocin
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Chemotherapeutic, Hypolipidemic
[+]

Crocetin and crocin from saffron in cancer chemotherapy and chemoprevention.Dec 29, 2018

Pubmed Data : Anticancer Agents Med Chem. 2018 Dec 30. Epub 2018 Dec 30. PMID: 30599111
Article Published Date : Dec 29, 2018
Study Type : Review
Additional Links
Substances : Crocetin, Crocin, Saffron
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive, Chemotherapeutic
[+]

Crocetin and crocins activate different mechanisms involved in the vasoconstriction pathway in hypertension.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2015 ;20(9):17570-84. Epub 2015 Sep 22. PMID: 26402666
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Crocetin, Crocin, Saffron
Diseases : Hypertension
Pharmacological Actions : Vasodilator Agents
Additional Keywords : Plant Extracts
[+]

crocetin as a potential candidate for preventing and treating ischemic stroke. Jan 20, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2023 Jan 21 ;14(1):50. Epub 2023 Jan 21. PMID: 36681688
Article Published Date : Jan 20, 2023
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Stroke: Ischemic
Pharmacological Actions : Neuroprotective Agents
[+]

Crocetin attenuates sepsis-induced cardiac dysfunction.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Physiol. 2020 ;11:514. Epub 2020 Jun 9. PMID: 32581829
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Lipopolysaccharide-Induced Toxicity, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocetin beta-d-glucosyl ester from Crocus sativus biowastes showed antiproliferative effects.Feb 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2020 Mar ;27(3):975-984. Epub 2020 Jan 27. PMID: 32127777
Article Published Date : Feb 29, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocetin, Saffron
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative
[+]

Crocetin can have therapeutic value for treating predominant diseases of Th2 or Th17 cells.Feb 05, 2023

Pubmed Data : Biofactors. 2023 Feb 6. Epub 2023 Feb 6. PMID: 36747328
Article Published Date : Feb 05, 2023
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Immune Dysregulation: TH1/TH2 imbalance
Pharmacological Actions : Immunomodulatory, Nitric Oxide Inhibitor
[+]

Crocetin combined with cisplatin exerts a synergistic anticancer effect by up-regulating the p53/p21 pathway.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2017 ;17:98. Epub 2017 Oct 30. PMID: 29093644
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Esophageal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer, P21 Activation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Crocetin could be a promising drug for treatment of COVID-19. Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2020 Dec ;6(12):e05681. Epub 2020 Dec 13. PMID: 33344790
Article Published Date : Nov 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocetin, Saffron
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Crocetin could quench drug resistance through modulation of MRP transporters in the drug resistant human ovarian cancer cells.Oct 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2018 Nov ;21(11):1192-1197. PMID: 30483395
Article Published Date : Oct 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Cancers: Multi-Drug Resistant, Ovarian Cancer
Pharmacological Actions : Chemotherapeutic
[+]

Crocetin exerts a prominent chemopreventive effect against esophageal cancer through the inhibition of cell proliferation, migration and induction of apoptosis.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2015 Mar ;9(3):1254-1260. Epub 2015 Jan 13. PMID: 25663893
Article Published Date : Feb 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Esophageal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Caspase-3 Activation, Chemopreventive
[+]

Crocetin exerts hypocholesterolemic effect by inducing LDLR and inhibiting PCSK9 and Sortilin in HepG2 cells.Dec 31, 2021

Pubmed Data : Nutr Res. 2022 02 ;98:41-49. Epub 2021 Sep 9. PMID: 35093763
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Hypercholesterolemia
Pharmacological Actions : Hypolipidemic
[+]

Crocetin exerts its anti-inflammatory property in LPS-induced RAW264.7 cells.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2021 ;2021:6631929. Epub 2021 Sep 10. PMID: 34545298
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Crocetin exhibits anti-cancer and chemosensitizing properties. Oct 10, 2011

Pubmed Data : Acta Pharmacol Sin. 2011 Oct 10. Epub 2011 Oct 10. PMID: 21986580
Article Published Date : Oct 10, 2011
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Cancers: All
Pharmacological Actions : Chemosensitizer
[+]

Crocetin imparts antiproliferative activity in hepatocellular carcinoma.Sep 11, 2021

Pubmed Data : IUBMB Life. 2021 Sep 12. Epub 2021 Sep 12. PMID: 34514729
Article Published Date : Sep 11, 2021
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Bcl-2 protein down-regulation, Bcl-xL down-regulation, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, STAT3 Inhibitor, Survivin Down-Regulation, Vascular Endothelial Growth Factor Inhibitors
[+]

Crocetin is a potential anticancer agent that can be used for cancer prevention and treatment.Nov 30, 2019

Pubmed Data : J Food Sci Technol. 2019 Dec ;56(12):5435-5443. Epub 2019 Aug 17. PMID: 31749491
Article Published Date : Nov 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocetin, Saffron
Diseases : Breast Cancer, Cervical Cancer, Lung Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive
[+]

Crocetin is a potential candidate to be included in dietary therapies aimed at reversing adipose tissue accumulation in obesity.Nov 11, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2020 Nov 12 ;9(11). Epub 2020 Nov 12. PMID: 33198073
Article Published Date : Nov 11, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents
[+]

Crocetin may increase autophagic cell death in fluorouracil-treated breast cancer cells.Feb 28, 2017

Pubmed Data : Tumour Biol. 2017 Mar ;39(3):1010428317694536. PMID: 28351329
Article Published Date : Feb 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Crocetin may mitigate the severity of asthma through suppressing Foxp3.Dec 31, 2014

Pubmed Data : Cell Physiol Biochem. 2015 ;37(6):2425-33. Epub 2015 Dec 9. PMID: 26646898
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Asthma
Pharmacological Actions : Immunomodulatory
[+]

Crocetin might halt or delay disease progression in age-related macular degeneration.Apr 21, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 Apr 22 ;21(8). Epub 2020 Apr 22. PMID: 32331354
Article Published Date : Apr 21, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Macular Degeneration
Pharmacological Actions : Antioxidants
[+]

Crocetin protects against mitochondrial damage induced by UV-A irradiation in corneal epithelial cell line HCE-T cells.Nov 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Sci. 2022 Dec ;150(4):279-288. Epub 2022 Oct 14. PMID: 36344051
Article Published Date : Nov 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Eye Damage, Oxidative Stress, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Antioxidants, Photoprotective
[+]

Crocetin suppresses angiogenesis and metastasis through inhibiting sonic hedgehog signaling pathway in gastric cancer.Oct 21, 2021

Pubmed Data : Biochem Biophys Res Commun. 2021 Oct 22 ;576:86-92. Epub 2021 Aug 31. PMID: 34482028
Article Published Date : Oct 21, 2021
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Gastric Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic
[+]

Crocetin suppresses the growth and migration in HCT-116 human colorectal cancer cells.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Res Pharm Sci. 2020 Dec ;15(6):592-601. Epub 2020 Nov 27. PMID: 33828602
Article Published Date : Nov 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Delivering crocetin across the blood-brain barrier by using γ-cyclodextrin to treat Alzheimer's disease.Feb 26, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2020 Feb 27 ;10(1):3654. Epub 2020 Feb 27. PMID: 32107408
Article Published Date : Feb 26, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Blood Brain Barrier
[+]

Encapsulation of crocetin into nanoparticles overcomes drug resistance in human ovarian cisplatin-resistant carcinoma cell line.Oct 22, 2019

Pubmed Data : Mol Biol Rep. 2019 Oct 23. Epub 2019 Oct 23. PMID: 31646427
Article Published Date : Oct 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Cancers: Drug Resistant, Ovarian Cancer
Pharmacological Actions : Multidrug Resistance Gene Modulators
[+]

Immunoregulatory and anti-inflammatory properties of Crocus sativus and its main active constituentsMar 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2019 Apr ;22(4):334-344. PMID: 31223464
Article Published Date : Mar 31, 2019
Study Type : Review
Additional Links
Substances : Crocetin, Crocin, Saffron
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Immunomodulatory, Interleukin-12 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor
[+]

Protection of H9c2 myocardial cells from oxidative stress by crocetin.May 25, 2023

Pubmed Data : J Vis Exp. 2023 May 26(195). Epub 2023 May 26. PMID: 37306415
Article Published Date : May 25, 2023
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective
[+]

Protective effects of crocetin against radiation-induced injury in intestinal epithelial cells.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2020 ;2020:2906053. Epub 2020 Sep 8. PMID: 32964024
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Radiation
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-1 beta downregulation, Radioprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Retinoprotective effects of crocin and crocetin via anti-angiogenic mechanism in high glucose-induced human retinal pigment epithelium cells.Apr 18, 2021

Pubmed Data : Curr Mol Pharmacol. 2021 Apr 19. Epub 2021 Apr 19. PMID: 33881975
Article Published Date : Apr 18, 2021
Study Type : In Vitro Study
Additional Links
Substances : Crocetin, Crocin
Diseases : Diabetic Retinopathy
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Natural Substances Versus Drugs
[+]

Saffron bioactives crocin, crocetin and safranal: effect on oxidative stress and mechanisms of action.Dec 23, 2020

Pubmed Data : Crit Rev Food Sci Nutr. 2020 Dec 24:1-18. Epub 2020 Dec 24. PMID: 33356506
Article Published Date : Dec 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocetin, Crocin, Saffron, Safranal
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation
[+]

Saffron may be a helpful alimentary component in the prevention of cancer.Jul 18, 2017

Pubmed Data : J Agric Food Chem. 2017 Jul 19 ;65(28):5639-5649. Epub 2017 Jul 7. PMID: 28643510
Article Published Date : Jul 18, 2017
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Cervical Cancer, Lung Cancer
Pharmacological Actions : Antiproliferative , Enzyme Inhibitors
[+]

Single TCM chemicals and their simple mixtures have potential for use in adjunct chemoprotective therapy.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharm Pharm Sci. 2015 ;18(4):661-82. PMID: 26626254
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Baicalein, Crocetin, Resveratrol
Diseases : Cancers: All, Chemotherapy and Radiation Toxicity
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Traditional Chinese Medicine
[+]

Study of the mechanisms of crocetin-induced differentiation and apoptosis in human acute promyelocytic leukemia cells.Sep 10, 2018

Pubmed Data : J Cell Biochem. 2018 Sep 11. Epub 2018 Sep 11. PMID: 30203596
Article Published Date : Sep 10, 2018
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Leukemia: Acute promyelocytic leukemia
Pharmacological Actions : Apoptotic
[+]

The effects of crocetin on oxidative stress induced ARPE-19 cells by H2O2.Nov 10, 2022

Pubmed Data : Exp Eye Res. 2022 Nov 11 ;226:109305. Epub 2022 Nov 11. PMID: 36372214
Article Published Date : Nov 10, 2022
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

The mechanism of crocetin targeting cardiovascular disease.Oct 16, 2022

Pubmed Data : Chem Biodivers. 2022 Oct 17:e202200685. Epub 2022 Oct 17. PMID: 36251941
Article Published Date : Oct 16, 2022
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Cardiovascular Disease
Pharmacological Actions : Cardioprotective
[+]

These data corroborated that crocetin could restore the dysfunction of diabetic endothelial progenitor cells.Jul 14, 2017

Pubmed Data : Life Sci. 2017 Jul 15 ;181:9-16. Epub 2017 May 18. PMID: 28528862
Article Published Date : Jul 14, 2017
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Diabetic Complications, Endothelial Dysfunction
Pharmacological Actions : Antioxidants, Nitric Oxide Enhancer
Additional Keywords : Antioxidants, Crocetin, Diabetic Complications, endothelial dysfunction, Endothelial Progenitor Cells (EPCs), Nitric Oxide Enhancer
[+]

These findings reveal crocetin's potential use as a calcium channel antagonist for the treatment of cardiovascular disease.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2020 ;43(9):1367-1374. PMID: 32879211
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective
[+]

These findings suggested that crocetin interfered with multiple signal pathways in KYSE-150 cells. Feb 14, 2019

Pubmed Data : Pharmacology. 2019 Feb 15 ;103(5-6):263-272. Epub 2019 Feb 15. PMID: 30783055
Article Published Date : Feb 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Esophageal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, P21 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

This review provides a brief insight into the anticancer properties of saffron and its components. Mar 31, 2015

Pubmed Data : J Tradit Complement Med. 2015 Apr ;5(2):81-7. Epub 2015 Jan 28. PMID: 26151016
Article Published Date : Mar 31, 2015
Study Type : Review
Additional Links
Substances : Crocetin, Crocin, Saffron, Safranal
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive
[+]

This review summarizes the protective action of carotenoids against the development and progression of NAFLD.May 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Prev Nutr Food Sci. 2019 Jun ;24(2):103-113. Epub 2019 Jun 30. PMID: 31328113
Article Published Date : May 31, 2019
Study Type : Review
Additional Links
Substances : Astaxanthin, B-Carotene, Crocetin, Cryptoxanthin, Fucoxanthin , Lutein, Lycopene
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective

Copyright: juggle33 / 123RF Stock Photo

Crocetin Related Articles

Saffron: Ancient Healing Powers Confirmed by Science
Written by Sayer Ji, Founder
Clearly there is something magical about the Crocus sativus flower, from which the spice saffron is derived. If its striking beauty does not immediately cast a spell on its beholder, often it simply takes experiencing the spice to fall into full enchantment with it.

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