Crocin

Name	AC	CK
Depression	1	10
Diabetes Mellitus: Type 2	3	6
Oxidative Stress	3	6
Parkinson's Disease	3	6
Breast Cancer	4	5
Head and Neck Cancer	1	5
Asthma	2	4
Cerebral Ischemia	2	4
Chemotherapy-Induced Toxicity: Doxorubicin	2	4
Inflammation	2	4
Ischemia	2	4
Kidney Damage	2	4
Neurodegenerative Diseases	2	4
Alzheimer's Disease	2	3
Allergic Airway Diseases	1	2
Anorexia: Stress-Induced	1	2
Bisphenol Toxicity	1	2
Brain: Oxidative Stress	1	2
Breast Cancer: Chemically-Induced	1	2
Cancers: All	2	2
Cardiovascular Diseases	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
DNA damage	1	2
Delayed Sleep Phase Disorder	1	2
Diabetes: Memory Problems	1	2
Diabetes: Oxidative Stress	1	2
Diabetic Complications	1	2
Diabetic Nephropathy	1	2
Hemorrhagic Shock	1	2
High Fat Diet	1	2
Hyperglycemia	1	2
Insomnia	1	2
Insulin Resistance	1	2
Kidney Diseases	1	2
Liver Cancer	1	2
Liver Damage	1	2
Liver Damage: Drug-Induced	1	2
Liver Injury: Ischemia/reperfusion	1	2
Low Back Pain	1	2
Melanoma	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Mycotoxin Toxicity	1	2
Myocardial Ischemia	1	2
Nicotine/Tobacco Toxicity	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Obesity	1	2
Osteoarthritis	1	2
Ovarian Cancer	2	2
Pesticide-Induced Toxicity: Organophosphates	1	2
Rheumatoid Arthritis	1	2
Sleep Disorders	1	2
Traumatic Brain Injury	1	2
Acute lymphoblastic leukemia (ALL)	1	1
Aspergillosis	1	1
Cancers: Drug Resistant	1	1
Cancers: Multi-Drug Resistant	1	1
Cervical Cancer	1	1
Chronic Obstructive Pulmonary Disease	1	1
Diabetic Retinopathy	1	1
Glaucoma	1	1
Helicobacter Pylori Infection	1	1
Hypertension	1	1
Leishmaniasis	1	1
Lung Cancer	1	1
Oral Cancer	1	1
Plasmodium Infections	1	1
Squamous cell carcinoma	1	1

Name	AC	CK
Antioxidants	16	31
Anti-Inflammatory Agents	14	26
Neuroprotective Agents	10	19
Apoptotic	10	12
Antiproliferative	10	11
Antidepressive Agents	1	10
Cardioprotective	5	10
Hepatoprotective	5	10
Anti-Apoptotic	4	7
Cytoprotective	3	6
Interleukin-6 Downregulation	3	6
MicroRNA modulator	3	6
Radiosensitizer	2	6
Renoprotective	3	6
Tumor Necrosis Factor (TNF) Alpha Inhibitor	3	6
Chemopreventive	3	5
Chemoprotective Agents	2	4
Hypoglycemic Agents	2	4
Interleukin-1 beta downregulation	2	4
Interleukin-4 downregulation	2	4
interleukin-13 down-regulation	2	4
Chemosensitizer	3	3
Chemotherapeutic	2	3
NF-kappaB Inhibitor	2	3
Anti-Asthmatic Agents	1	2
Anticarcinogenic Agents	1	2
Autophagy Inhibitors	1	2
Autophagy Up-regulation	1	2
Bcl-2 protein down-regulation	2	2
Fertility Agents: Male	1	2
Gastroprotective	1	2
Interferon Gamma Reducer	1	2
Interleukin-10 downregulation	1	2
Interleukin-5 downregulation	1	2
Nrf2 activation	1	2
Radioprotective	1	2
Tumor Suppressor Protein p53 Upregulation	2	2
Vascular Endothelial Growth Factor A Enhancer	1	2
Anti-Bacterial Agents	1	1
Anti-metastatic	1	1
Antineoplastic Agents	1	1
Antiparasitic Agents	1	1
Caspase-3 Activation	1	1
Cell cycle arrest	1	1
Multidrug Resistance Gene Modulators	1	1
Telomerase Inhibitor	1	1
Vasodilator Agents	1	1

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Saffron and crocin may modulate the serum lipid profile in patient with metabolic disorders.Feb 03, 2020

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Pubmed Data : Arch Physiol Biochem. 2020 Feb 4:1-13. Epub 2020 Feb 4. PMID: 32013614

Article Published Date : Feb 03, 2020

Study Type : Meta Analysis, Review

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Substances : Crocin, Saffron

Diseases : Hyperglycemia, Hyperlipidemia

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic

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The findings indicate that crocin supplementation can improve glycemic control and insulin resistance in patients with T2D.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Pharmacol Rep. 2019 Aug ;71(4):746-752. Epub 2019 Apr 16. PMID: 31220735

Article Published Date : Jul 31, 2019

Study Type : Animal Study

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Substances : Crocin

Diseases : Drug Toxicity: Methotrexate, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Methotrexate

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Crocin and crocetin showed a significant protective effect against the N-methyl-N-nitrosourea induced breast cancer in rats.Mar 31, 2017

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Pubmed Data : Drug Chem Toxicol. 2019 Feb 3:1-8. Epub 2019 Feb 3. PMID: 30714419

Article Published Date : Feb 02, 2019

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents

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Crocin at a dose of 60 mg/kg for six weeks could be effective in preventing nitrosative stress in hemiparkinsonian rats.Oct 31, 2016

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Pubmed Data : Biomed Res Int. 2020 ;2020:9136282. Epub 2020 Jun 6. PMID: 32596392

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Insulin Resistance, Obesity

Pharmacological Actions : Insulin Sensitizers

Additional Keywords : Anti-Obesity Agents

[+]

Crocin improves nicotine-induced adverse effects on reproductive parameters in male mice.Mar 31, 2016

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Pubmed Data : Pharmacol Biochem Behav. 2015 Dec ;139(Pt A):47-58. Epub 2015 Oct 17. PMID: 26484504

Article Published Date : Nov 30, 2015

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Alzheimer's Disease, Neurodegenerative Diseases, Parkinson's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Crocin inhibits obesity via AMPK-dependent inhibition of adipocyte differentiation and promotion of lipolysis.Dec 31, 2017

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[+]

Crocin protected the liver against IR injury through increasing the activity of antioxidant enzymes.Dec 31, 2016

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Pubmed Data : Oxid Med Cell Longev. 2017 ;2017:1702967. Epub 2017 Mar 6. PMID: 28367266

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Carotenoids, Crocin

Diseases : Liver Injury: Ischemia/reperfusion

Pharmacological Actions : Antioxidants, Hepatoprotective, MicroRNA modulator, Nrf2 activation

[+]

Crocin protects against genotoxic stress induced by gamma radiation, urethane and procarbazine in mice.Dec 31, 2016

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Pubmed Data : Hum Exp Toxicol. 2017 Jan 1:960327116689715. Epub 2017 Jan 1. PMID: 28111973

Additional Keywords : Endocannabinoid System

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Crocin, a constituent of Saffron, can significantly reduce infarcted areas caused by occlusion of the middle cerebral artery (MCA) in mice.Apr 01, 2007

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Pubmed Data : Biochim Biophys Acta. 2007 Apr;1770(4):578-84. Epub 2006 Dec 5. PMID: 17215084

Article Published Date : Apr 01, 2007

Study Type : Animal Study

Additional Links

Substances : Carotenoids, Crocin, Saffron

Diseases : Middle Cerebral Artery Occlusion (MCAO)

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

Crocin, an active constituent of Crocus sativus ameliorates cerulein induced pancreatic inflammation and oxidative stress.Nov 24, 2019

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Pubmed Data : Phytother Res. 2019 Nov 25. Epub 2019 Nov 25. PMID: 31769107

Saffron extract and crocin supplements have hepatoprotective effect against non-alcoholic fatty liver disease and HFD-induced liver damage.Oct 21, 2016

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Pubmed Data : BMC Complement Altern Med. 2016 Oct 22 ;16(1):401. Epub 2016 Oct 22. PMID: 27770798

Article Published Date : Oct 21, 2016

Study Type : Animal Study

Additional Links

Substances : Crocin, Saffron

Diseases : Liver Damage, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

[+]

Saffron may be exploited as a supplementary therapeutic agent in PD and other oxidative stress mediated neurodegenerative conditions.Dec 16, 2015

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Pubmed Data : Neurotoxicology. 2015 Dec 17 ;52:230-242. Epub 2015 Dec 17. PMID: 26705857

Article Published Date : Dec 16, 2015

Study Type : Insect Study

Additional Links

Substances : Crocin, Saffron

Diseases : Neurodegenerative Diseases, Oxidative Stress, Parkinson's Disease

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

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Pubmed Data : Arq Bras Cardiol. 2017 Jun 29:0. Epub 2017 Jun 29. PMID: 28678929

Article Published Date : Jun 28, 2017

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Pubmed Data : DNA Cell Biol. 2018 Aug ;37(8):697-707. Epub 2018 Jul 3. PMID: 29969282

Article Published Date : Jul 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Crocetin, Crocin, Saffron

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic, Wnt/β-catenin signaling pathway modulation

[+]

A comprehensive review on anticancer mechanisms of crocin.Jul 02, 2017

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Pubmed Data : J Pharm Pharmacol. 2017 Jul 3. Epub 2017 Jul 3. PMID: 28675431

Article Published Date : Jul 02, 2017

Study Type : Review

Additional Links

Substances : Crocin

Diseases : Cancers: All

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Chemotherapeutic, Telomerase Inhibitor

Additional Keywords : Anti-metastatic, Antiproliferative, Apoptotic, Cancers: All, Chemotherapeutic, Crocin, Telomerase Inhibitor

[+]

A review of the therapeutic effects of crocin in autoimmune diseases.Aug 19, 2019

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Pubmed Data : Biofactors. 2019 Aug 20. Epub 2019 Aug 20. PMID: 31430413

Article Published Date : Aug 19, 2019

Study Type : Review

Additional Links

Substances : Crocin

Diseases : Asthma, Autoimmune Diseases, Diabetes Mellitus: Type 1, Multiple Sclerosis, Rheumatoid Arthritis, Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

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Crocin and picrocrocin could be a promising anti-HSV and anti-HIV agent for herbal therapy against viral infections.Dec 31, 2017

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Pubmed Data : Curr Drug Deliv. 2018 ;15(5):698-704. PMID: 29189153

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Pubmed Data : West Indian Med J. 2016 Apr 18. Epub 2016 Apr 18. PMID: 27398676

Crocin inhibited cell proliferation mainly by disrupting the microtubule network.Mar 23, 2017

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View the Evidence: 147 Abstracts with Crocin Research

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Saffron and crocin may modulate the serum lipid profile in patient with metabolic disorders.Feb 03, 2020

The findings indicate that crocin supplementation can improve glycemic control and insulin resistance in patients with T2D.Dec 31, 2019

Crocin can be considered for treatment of burning mouth syndrome.Oct 31, 2019

These results demonstrated the effect of crocin in depression and could be administered in treatment of MDD patients.Mar 14, 2015

These results suggest the beneficial and therapeutic effects of crocin in multiple sclerosis.Oct 15, 2019

Crocin can be considered as a potential drug and sensitizer in cancer treatment. Dec 31, 2016

Pathogenesis and anti-proliferation mechanisms of crocin in human gastric carcinoma cells.Dec 31, 2019

Crocin ameliorates oxidative stress and suppresses renal damage in streptozotocin induced diabetic male rats.Aug 23, 2020

Administration of crocin reduced d-galactose-induced aging.Dec 31, 2017

Ameliorative effect of crocin on sperm parameters and in vitro fertilization in mice under oxidative stress induced by paraquat.Dec 31, 2019

Ameliorative effects of crocin on paraquat-induced oxidative stress in testis.Nov 30, 2019

Anti-metastatic properties of a potent herbal combination in cell and mice models of triple negative breast cancer.Feb 14, 2020

Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone.Oct 11, 2019

Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice.Apr 30, 2018

Cognitive protective mechanism of crocin pretreatment in rat submitted to acute high-altitude hypoxia exposure.Dec 31, 2019

Crocin administration could protect the liver damage induced by morphine.Feb 29, 2016

Crocin administration may reduce inflammation-driven tissue damage in patients with hemorrhagic shock.Apr 27, 2017

Crocin alleviates lipopolysaccharide-induced acute respiratory distress syndrome.Jan 09, 2020

Crocin ameliorates atopic dermatitis symptoms by down regulation of the Th2 cells-mediated immune response.Nov 01, 2018

Crocin ameliorates chronic obstructive pulmonary disease-induced depression.Sep 02, 2019

Crocin ameliorates hepatic steatosis through activation of AMPK signalling.Jan 07, 2019

Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation.Jul 31, 2019

Crocin and crocetin showed a significant protective effect against the N-methyl-N-nitrosourea induced breast cancer in rats.Mar 31, 2017

Crocin and crocetin significantly increased the total time of non-rapid eye movement (non-REM) sleep after the administration.Jan 31, 2012

Crocin and voluntary exercise promote heart angiogenesis through Akt and ERK1/2 signalling in type 2 diabetic rats.Dec 31, 2017

Crocin as a novel therapeutic agent against colitis.Feb 02, 2019

Crocin at a dose of 60 mg/kg for six weeks could be effective in preventing nitrosative stress in hemiparkinsonian rats.Oct 31, 2016

Crocin attenuates CCl 4-induced liver fibrosis via PPAR-γ mediated modulation of inflammation and fibrogenesis in rats.Nov 30, 2020

Crocin attenuates cyclophosphamide induced testicular toxicity by preserving glutathione redox system.Apr 30, 2018

Crocin attenuates isoprenaline-induced myocardial fibrosis.Aug 06, 2019

Crocin attenuates lung inflammation and pulmonary vascular dysfunction in a rat model of bleomycin-induced pulmonary fibrosis.Aug 25, 2019

Crocin attenuates metabolic syndrome-induced osteoporosis.Jun 30, 2019

Crocin attenuates osteoarthritis symptoms through alleviating oxidative stress and inflammation.Aug 06, 2017

Crocin can improve oxidative stress in pancreatic cells by potentiating the anti-oxidant defense system.May 31, 2019

Crocin can improve the synaptic loss and neuronal death.Jun 09, 2020

Crocin combined with voluntary exercise improved insulin resistance and reduced glucose levels in diabetic rats.Apr 18, 2016

Crocin contributed to the alleviation of some complications of diabetes.Nov 30, 2020

Crocin could contribute to the development of phytotherapeutic approaches in the treatment of obesity and diabetes.Nov 16, 2016

Crocin demonstrates good prospects in the treatment of Alzheimer's disease through the oxidative stress associated apoptosis signalling pathway.Dec 17, 2018

Crocin had a superior effect compared to sitagliptin on blood sugar level, β-islets diameter and insulin immune-reactivity.Jul 30, 2019

Crocin has a cardioprotective effect against DOX-induced cardiomayopathy.Mar 04, 2016

Crocin has a paradoxical protective effect by regulating both the induction and inhibition of autophagy in ischemia and reperfusion injury.Apr 23, 2016

Crocin has a protective effect of on gastric mucosal lesions induced by ischemia-reperfusion injury in rats.Dec 31, 2015

Crocin has a renoprotective effects against the development of oxidative stress and inflammation in the kidney of old rats.Jun 08, 2016

Crocin has a role in attenuation of induced ulcerative colitis in rats.Jan 31, 2019

Crocin has anti-inflammatory and protective effects in ischemia-reperfusion induced renal injuries.Jun 30, 2017

Crocin has potential for use as a therapuetic strategy in the treatment of lower back pain. Oct 31, 2015

Crocin has protective activities against ethanol toxic effects in the liver and kidney.Dec 31, 2019

Crocin has protective effects against gentamicin-induced nephrotoxicity in rats.Feb 29, 2016

Crocin improved memory under unpredictable stress conditions.Dec 31, 2017

Crocin improves cognitive behavior in rats with Alzheimer's disease.Dec 31, 2018

Crocin improves insulin sensitivity and ameliorates adiposity.Dec 31, 2019

Crocin improves nicotine-induced adverse effects on reproductive parameters in male mice.Mar 31, 2016

Crocin improves spatial learning and memory deficits in diabetic rats.Jan 26, 2017

Crocin induced caspase mediated MCF-7 cell death.Dec 31, 2015

Crocin inhibits beta amyloid induced apoptosis, which is possibly associated with its antioxidant properties.Nov 30, 2015

Crocin inhibits obesity via AMPK-dependent inhibition of adipocyte differentiation and promotion of lipolysis.Dec 31, 2017

Crocin is a candidate chemopreventive agent against hepatocellular carcinoma.Oct 31, 2015

Crocin is protective against cardiovascular-related disorders produced by doxorubicin.Jun 09, 2016

Crocin may exert antiapoptotic, antioxidant and protective effects in IR-mediated brain injury induced by four-vessel occlusion.Apr 22, 2016

Crocin may exert potent anti- rheumatoid arthritis effects through inhibiting cytokines.Apr 30, 2017

Crocin may exhibit significant melanoma tumor remission properties by positively modulating tumor growth related parameters.Dec 31, 2016

Crocin may have beneficial effects on coronary artery disease patients.Dec 02, 2019

Crocin mediated amelioration of oxidative burden and inflammatory cascade suppresses diabetic nephropathy progression in diabetic rats.Mar 24, 2018

Crocin or related antioxidants may protect against cerebral ischemia.Dec 31, 2016

Crocin possesses hepatoprotective effects against BPA-induced liver toxicity.Jul 04, 2017

Crocin protected the liver against IR injury through increasing the activity of antioxidant enzymes.Dec 31, 2016

Crocin protects against genotoxic stress induced by gamma radiation, urethane and procarbazine in mice.Dec 31, 2016

Crocin protects the liver and kidney from patulin-induced apoptosis.Feb 08, 2016

Crocin reduced the toxic effects of diazinon by inhibiting apoptosis in aortic tissue.Jun 30, 2016

Crocin reverses depression-like behaviour in Parkinson disease.Jun 02, 2020

Crocin showed a significant protective effect against allergic asthma progression.Aug 31, 2017

Crocin

View the Evidence:
147 Abstracts with Crocin Research