Crocin

Name	AC	CK
Depression	1	10
Diabetes Mellitus: Type 2	3	6
Oxidative Stress	3	6
Parkinson's Disease	3	6
Breast Cancer	4	5
Head and Neck Cancer	1	5
Asthma	2	4
Cerebral Ischemia	2	4
Chemotherapy-Induced Toxicity: Doxorubicin	2	4
Inflammation	2	4
Ischemia	2	4
Kidney Damage	2	4
Neurodegenerative Diseases	2	4
Alzheimer's Disease	2	3
Allergic Airway Diseases	1	2
Anorexia: Stress-Induced	1	2
Bisphenol Toxicity	1	2
Brain: Oxidative Stress	1	2
Breast Cancer: Chemically-Induced	1	2
Cancers: All	2	2
Cardiovascular Diseases	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
DNA damage	1	2
Delayed Sleep Phase Disorder	1	2
Diabetes: Memory Problems	1	2
Diabetes: Oxidative Stress	1	2
Diabetic Complications	1	2
Diabetic Nephropathy	1	2
Hemorrhagic Shock	1	2
High Fat Diet	1	2
Hyperglycemia	1	2
Insomnia	1	2
Insulin Resistance	1	2
Kidney Diseases	1	2
Liver Cancer	1	2
Liver Damage	1	2
Liver Damage: Drug-Induced	1	2
Liver Injury: Ischemia/reperfusion	1	2
Low Back Pain	1	2
Melanoma	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Mycotoxin Toxicity	1	2
Myocardial Ischemia	1	2
Nicotine/Tobacco Toxicity	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Obesity	1	2
Osteoarthritis	1	2
Ovarian Cancer	2	2
Pesticide-Induced Toxicity: Organophosphates	1	2
Rheumatoid Arthritis	1	2
Sleep Disorders	1	2
Traumatic Brain Injury	1	2
Acute lymphoblastic leukemia (ALL)	1	1
Aspergillosis	1	1
Cancers: Drug Resistant	1	1
Cancers: Multi-Drug Resistant	1	1
Cervical Cancer	1	1
Chronic Obstructive Pulmonary Disease	1	1
Diabetic Retinopathy	1	1
Glaucoma	1	1
Helicobacter Pylori Infection	1	1
Hypertension	1	1
Leishmaniasis	1	1
Lung Cancer	1	1
Oral Cancer	1	1
Plasmodium Infections	1	1
Squamous cell carcinoma	1	1

Name	AC	CK
Antioxidants	16	31
Anti-Inflammatory Agents	14	26
Neuroprotective Agents	10	19
Apoptotic	10	12
Antiproliferative	10	11
Antidepressive Agents	1	10
Cardioprotective	5	10
Hepatoprotective	5	10
Anti-Apoptotic	4	7
Cytoprotective	3	6
Interleukin-6 Downregulation	3	6
MicroRNA modulator	3	6
Radiosensitizer	2	6
Renoprotective	3	6
Tumor Necrosis Factor (TNF) Alpha Inhibitor	3	6
Chemopreventive	3	5
Chemoprotective Agents	2	4
Hypoglycemic Agents	2	4
Interleukin-1 beta downregulation	2	4
Interleukin-4 downregulation	2	4
interleukin-13 down-regulation	2	4
Chemosensitizer	3	3
Chemotherapeutic	2	3
NF-kappaB Inhibitor	2	3
Anti-Asthmatic Agents	1	2
Anticarcinogenic Agents	1	2
Autophagy Inhibitors	1	2
Autophagy Up-regulation	1	2
Bcl-2 protein down-regulation	2	2
Fertility Agents: Male	1	2
Gastroprotective	1	2
Interferon Gamma Reducer	1	2
Interleukin-10 downregulation	1	2
Interleukin-5 downregulation	1	2
Nrf2 activation	1	2
Radioprotective	1	2
Tumor Suppressor Protein p53 Upregulation	2	2
Vascular Endothelial Growth Factor A Enhancer	1	2
Anti-Bacterial Agents	1	1
Anti-metastatic	1	1
Antineoplastic Agents	1	1
Antiparasitic Agents	1	1
Caspase-3 Activation	1	1
Cell cycle arrest	1	1
Multidrug Resistance Gene Modulators	1	1
Telomerase Inhibitor	1	1
Vasodilator Agents	1	1

Pubmed Data : Int J Reprod Biomed (Yazd). 2019 Dec ;17(11):807-818. Epub 2019 Dec 26. PMID: 31911963

Article Published Date : Nov 30, 2019

Study Type : Animal Study

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Substances : Crocin

Diseases : Pesticide Toxicity , Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Malondialdehyde Down-regulation

Problem Substances : Paraquat

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Ameliorative effects of crocin on tartrazine dye-induced pancreatic adverse effects.Aug 31, 2020

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Pubmed Data : Environ Sci Pollut Res Int. 2020 Sep 1. Epub 2020 Sep 1. PMID: 32870427

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Pubmed Data : Pharmacol Rep. 2019 Aug ;71(4):746-752. Epub 2019 Apr 16. PMID: 31220735

Article Published Date : Jul 31, 2019

Study Type : Animal Study

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Substances : Crocin

Diseases : Drug Toxicity: Methotrexate, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Methotrexate

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Crocin and crocetin showed a significant protective effect against the N-methyl-N-nitrosourea induced breast cancer in rats.Mar 31, 2017

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Pubmed Data : Drug Chem Toxicol. 2019 Feb 3:1-8. Epub 2019 Feb 3. PMID: 30714419

Article Published Date : Feb 02, 2019

Study Type : Animal Study

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Substances : Crocin

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents

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Crocin at a dose of 60 mg/kg for six weeks could be effective in preventing nitrosative stress in hemiparkinsonian rats.Oct 31, 2016

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Pubmed Data : Biomed Res Int. 2020 ;2020:9136282. Epub 2020 Jun 6. PMID: 32596392

Article Published Date : Dec 31, 2019

Study Type : Animal Study

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Substances : Crocin

Diseases : Insulin Resistance, Obesity

Pharmacological Actions : Insulin Sensitizers

Additional Keywords : Anti-Obesity Agents

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Crocin improves nicotine-induced adverse effects on reproductive parameters in male mice.Mar 31, 2016

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Pubmed Data : J Exp Pharmacol. 2020 ;12:97-106. Epub 2020 Apr 28. PMID: 32431552

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Pubmed Data : Hum Exp Toxicol. 2020 Oct 6:960327120954521. Epub 2020 Oct 6. PMID: 33021114

Article Published Date : Oct 05, 2020

Study Type : Animal Study

Additional Links

Substances : Crocin, Quercetin

Diseases : Diabetes Mellitus: Type 2, Kidney Damage, Obesity

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic, Renoprotective

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Saffron (Crocus sativus) aqueous extract and its constituent crocin reduces stress-induced anorexia in mice.Dec 01, 2011

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Pubmed Data : Phytother Res. 2011 Dec ;25(12):1833-8. Epub 2011 Apr 19. PMID: 21503997

Article Published Date : Dec 01, 2011

Study Type : Animal Study

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Substances : Crocin, Saffron

Diseases : Anorexia: Stress-Induced

Additional Keywords : Plant Extracts

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Saffron and its active constituent crocin can prevent chronic stress-induced oxidative stress damage of the brain, liver and kidneys.Nov 30, 2014

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Pubmed Data : Nutr Metab Cardiovasc Dis. 2018 Sep ;28(9):952-961. Epub 2018 Jul 14. PMID: 30017436

Article Published Date : Aug 31, 2018

Study Type : Animal Study

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Substances : Crocin

Diseases : Cardiomyopathy, Diabetic Complications

Pharmacological Actions : Cardioprotective

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Voluntary exercise and diet supplementation with crocin could have beneficial effects in prevention of cardiovascular disease.Jun 28, 2017

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Pubmed Data : Arq Bras Cardiol. 2017 Jun 29:0. Epub 2017 Jun 29. PMID: 28678929

Article Published Date : Jun 28, 2017

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Pubmed Data : DNA Cell Biol. 2018 Aug ;37(8):697-707. Epub 2018 Jul 3. PMID: 29969282

Article Published Date : Jul 31, 2018

Study Type : In Vitro Study

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Substances : Crocetin, Crocin, Saffron

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic, Wnt/β-catenin signaling pathway modulation

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A comprehensive review on anticancer mechanisms of crocin.Jul 02, 2017

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Pubmed Data : J Pharm Pharmacol. 2017 Jul 3. Epub 2017 Jul 3. PMID: 28675431

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Pubmed Data : Anticancer Agents Med Chem. 2018 Dec 30. Epub 2018 Dec 30. PMID: 30599111

Article Published Date : Dec 29, 2018

Study Type : Review

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Substances : Crocetin, Crocin, Saffron

Diseases : Cancers: All

Pharmacological Actions : Chemopreventive, Chemotherapeutic

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Crocetin and crocins activate different mechanisms involved in the vasoconstriction pathway in hypertension.Dec 31, 2014

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Pubmed Data : Curr Drug Deliv. 2018 ;15(5):698-704. PMID: 29189153

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Pubmed Data : West Indian Med J. 2016 Apr 18. Epub 2016 Apr 18. PMID: 27398676

Article Published Date : Apr 17, 2016

Study Type : In Vitro Study

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Substances : Crocin

Diseases : Acute lymphoblastic leukemia (ALL)

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Dose Response

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Pubmed Data : Asian Pac J Cancer Prev. 2020 07 1 ;21(7):1959-1967. Epub 2020 Jul 1. PMID: 32711421

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Crocin

Diseases : Gastric Cancer

Pharmacological Actions : Chemosensitizer, Multidrug Resistance Gene Modulators

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

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Crocin inhibited cell proliferation mainly by disrupting the microtubule network.Mar 23, 2017

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Pubmed Data : J Pharm Pharmacol. 2021 Feb 1. Epub 2021 Feb 1. PMID: 33793778

Article Published Date : Jan 31, 2021

Study Type : In Vitro Study

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Substances : Crocin

Diseases : Aluminum Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Cardioprotective

Problem Substances : Aluminum

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Pubmed Data : Transl Lung Cancer Res. 2015 Dec ;4(6):775-83. PMID: 26798587

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Pubmed Data : Iran J Parasitol. 2021 Jan-Mar;16(1):151-158. PMID: 33786057

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Crocin, Saffron, Stigmasterol

Diseases : Leishmaniasis

Pharmacological Actions : Leishmanicidal

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View the Evidence: 183 Abstracts with Crocin Research

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Saffron and crocin may modulate the serum lipid profile in patient with metabolic disorders.Feb 03, 2020

The effect of crocin supplementation on lipid concentrations and fasting blood glucose.Jul 31, 2020

The findings indicate that crocin supplementation can improve glycemic control and insulin resistance in patients with T2D.Dec 31, 2019

Crocin can be considered for treatment of burning mouth syndrome.Oct 31, 2019

Crocin is effective in treatment of patients with mild to moderate OCD with possibly fewer adverse effects compared to fluoxetine.Feb 17, 2021

These results demonstrated the effect of crocin in depression and could be administered in treatment of MDD patients.Mar 14, 2015

These results suggest the beneficial and therapeutic effects of crocin in multiple sclerosis.Oct 15, 2019

Crocin can be considered as a potential drug and sensitizer in cancer treatment. Dec 31, 2016

Pathogenesis and anti-proliferation mechanisms of crocin in human gastric carcinoma cells.Dec 31, 2019

Crocin ameliorates oxidative stress and suppresses renal damage in streptozotocin induced diabetic male rats.Aug 23, 2020

Administering crocin ameliorates anxiety-like behaviors and reduces the inflammatory response in amyloid-beta induced neurotoxicity.Mar 07, 2021

Administration of crocin reduced d-galactose-induced aging.Dec 31, 2017

Ameliorative effect of crocin on sperm parameters and in vitro fertilization in mice under oxidative stress induced by paraquat.Dec 31, 2019

Ameliorative effects of crocin on paraquat-induced oxidative stress in testis.Nov 30, 2019

Ameliorative effects of crocin on tartrazine dye-induced pancreatic adverse effects.Aug 31, 2020

Anti-metastatic properties of a potent herbal combination in cell and mice models of triple negative breast cancer.Feb 14, 2020

Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone.Oct 11, 2019

Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice.Apr 30, 2018

Antioxidant and anti-inflammatory effects of crocin ameliorate doxorubicin-induced nephrotoxicity.Dec 31, 2020

Cognitive protective mechanism of crocin pretreatment in rat submitted to acute high-altitude hypoxia exposure.Dec 31, 2019

Crocin administration could protect the liver damage induced by morphine.Feb 29, 2016

Crocin administration may reduce inflammation-driven tissue damage in patients with hemorrhagic shock.Apr 27, 2017

Crocin alleviates lipopolysaccharide-induced acute respiratory distress syndrome.Jan 09, 2020

Crocin ameliorates atopic dermatitis symptoms by down regulation of the Th2 cells-mediated immune response.Nov 01, 2018

Crocin ameliorates chronic obstructive pulmonary disease-induced depression.Sep 02, 2019

Crocin ameliorates hepatic steatosis through activation of AMPK signalling.Jan 07, 2019

Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation.Jul 31, 2019

Crocin and crocetin showed a significant protective effect against the N-methyl-N-nitrosourea induced breast cancer in rats.Mar 31, 2017

Crocin and crocetin significantly increased the total time of non-rapid eye movement (non-REM) sleep after the administration.Jan 31, 2012

Crocin and voluntary exercise promote heart angiogenesis through Akt and ERK1/2 signalling in type 2 diabetic rats.Dec 31, 2017

Crocin as a novel therapeutic agent against colitis.Feb 02, 2019

Crocin at a dose of 60 mg/kg for six weeks could be effective in preventing nitrosative stress in hemiparkinsonian rats.Oct 31, 2016

Crocin attenuates CCl 4-induced liver fibrosis via PPAR-γ mediated modulation of inflammation and fibrogenesis in rats.Nov 30, 2020

Crocin attenuates cyclophosphamide induced testicular toxicity by preserving glutathione redox system.Apr 30, 2018

Crocin attenuates isoprenaline-induced myocardial fibrosis.Aug 06, 2019

Crocin attenuates lung inflammation and pulmonary vascular dysfunction in a rat model of bleomycin-induced pulmonary fibrosis.Aug 25, 2019

Crocin attenuates metabolic syndrome-induced osteoporosis.Jun 30, 2019

Crocin attenuates osteoarthritis symptoms through alleviating oxidative stress and inflammation.Aug 06, 2017

Crocin attenuates oxidative stress and inflammation in myocardial infarction induced by isoprenaline.Nov 30, 2020

Crocin can improve oxidative stress in pancreatic cells by potentiating the anti-oxidant defense system.May 31, 2019

Crocin can improve the synaptic loss and neuronal death.Jun 09, 2020

Crocin combined with voluntary exercise improved insulin resistance and reduced glucose levels in diabetic rats.Apr 18, 2016

Crocin contributed to the alleviation of some complications of diabetes.Nov 30, 2020

Crocin could attenuate hyperalgesia induced by sleep deprivation.Apr 30, 2020

Crocin could contribute to the development of phytotherapeutic approaches in the treatment of obesity and diabetes.Nov 16, 2016

Crocin demonstrates good prospects in the treatment of Alzheimer's disease through the oxidative stress associated apoptosis signalling pathway.Dec 17, 2018

Crocin exhibits an antihypertensive effect in a rat model of gestational hypertension and activates the Nrf-2/HO-1 signaling pathway.Jan 12, 2021

Crocin had a superior effect compared to sitagliptin on blood sugar level, β-islets diameter and insulin immune-reactivity.Jul 30, 2019

Crocin has a cardioprotective effect against DOX-induced cardiomayopathy.Mar 04, 2016

Crocin has a paradoxical protective effect by regulating both the induction and inhibition of autophagy in ischemia and reperfusion injury.Apr 23, 2016

Crocin has a protective effect of on gastric mucosal lesions induced by ischemia-reperfusion injury in rats.Dec 31, 2015

Crocin has a renoprotective effects against the development of oxidative stress and inflammation in the kidney of old rats.Jun 08, 2016

Crocin has a role in attenuation of induced ulcerative colitis in rats.Jan 31, 2019

Crocin has anti-inflammatory and protective effects in ischemia-reperfusion induced renal injuries.Jun 30, 2017

Crocin has exerted neuroprotective effects in the rat model of MK-801-elicited schizophrenia.Sep 29, 2020

Crocin has potential for use as a therapuetic strategy in the treatment of lower back pain. Oct 31, 2015

Crocin has protective activities against ethanol toxic effects in the liver and kidney.Dec 31, 2019

Crocin has protective effects against gentamicin-induced nephrotoxicity in rats.Feb 29, 2016

Crocin improved memory under unpredictable stress conditions.Dec 31, 2017

Crocin improves cognitive behavior in rats with Alzheimer's disease.Dec 31, 2018

Crocin improves insulin sensitivity and ameliorates adiposity.Dec 31, 2019

Crocin improves nicotine-induced adverse effects on reproductive parameters in male mice.Mar 31, 2016

Crocin improves spatial learning and memory deficits in diabetic rats.Jan 26, 2017

Crocin induced caspase mediated MCF-7 cell death.Dec 31, 2015

Crocin induces autophagic cell death and inhibits cell invasion of cervical cancer SiHa cells through activation of PI3K/AKT.Aug 31, 2020

Crocin inhibits beta amyloid induced apoptosis, which is possibly associated with its antioxidant properties.Nov 30, 2015

Crocin inhibits obesity via AMPK-dependent inhibition of adipocyte differentiation and promotion of lipolysis.Dec 31, 2017

Crocin is a candidate chemopreventive agent against hepatocellular carcinoma.Oct 31, 2015

Crocin is protective against cardiovascular-related disorders produced by doxorubicin.Jun 09, 2016

Crocin may exert antiapoptotic, antioxidant and protective effects in IR-mediated brain injury induced by four-vessel occlusion.Apr 22, 2016

Crocin may exert potent anti- rheumatoid arthritis effects through inhibiting cytokines.Apr 30, 2017

Crocin may exhibit significant melanoma tumor remission properties by positively modulating tumor growth related parameters.Dec 31, 2016

Crocin

View the Evidence:
183 Abstracts with Crocin Research