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146 Diseases Researched for Crocin
NameACCKFocus
Depression729Locked
Anxiety424Locked
Hyperglycemia324Locked
Oxidative Stress1423Locked
Diabetes Mellitus: Type 2722Locked
Hyperlipidemia120Locked
Hypoglycemia120Locked
Insulin Resistance416Locked
Parkinson's Disease916Locked
Alzheimer's Disease812Locked
Inflammation812Locked
Obsessive-Compulsive Disorder212Locked
Breast Cancer911Locked
Multiple Sclerosis211Locked
Burning Mouth Syndrome110Locked
Gastric Cancer510Locked
Diabetic Nephropathy48Locked
Neurodegenerative Diseases68Locked
Obesity48Locked
Cerebral Ischemia57Locked
Pesticide Toxicity 47Locked
Asthma46Locked
Breast Cancer: Triple Negative 46Locked
Chemotherapy-Induced Toxicity: Doxorubicin36Locked
Diabetes: Oxidative Stress36Locked
Kidney Damage36Locked
Lipopolysaccharide-Induced Toxicity46Locked
Liver Damage36Locked
Liver Fibrosis36Locked
Memory Disorders36Locked
Neuropathic Pain36Locked
Head and Neck Cancer15Locked
Hypertension35Locked
Rheumatoid Arthritis35Locked
Bisphenol Toxicity24Locked
Brain Inflammation 24Locked
Brain: Oxidative Stress24Locked
Chemically-Induced Liver Damage24Locked
Colitis24Locked
DNA damage24Locked
Diabetic Complications24Locked
Hemorrhagic Shock24Locked
Hyperalgesia24Locked
Insomnia24Locked
Ischemia24Locked
Myocardial Infarction24Locked
Nonalcoholic fatty liver disease (NAFLD)24Locked
Pulmonary Fibrosis: Bleomycin-Induced24Locked
Sleep Disorders24Locked
Testicular Injury: Chemical/Metal Induced24Locked
Alcohol Toxicity 23Locked
Cancers: All33Locked
Cervical Cancer23Locked
Chronic Obstructive Pulmonary Disease23Locked
Colorectal Cancer23Locked
Diabetes Mellitus: Type 123Locked
Lipid Peroxidation23Locked
Liver Cancer23Locked
Pancreatic Cancer23Locked
Ulcerative Colitis23Locked
Aging12Locked
Aging: Liver12Locked
Alcohol Withdrawal12Locked
Alcoholic Liver Disease12Locked
Allergic Airway Diseases12Locked
Altitude Sickness12Locked
Anorexia: Stress-Induced12Locked
Atherosclerosis22Locked
Atopic Dermatitis12Locked
Breast Cancer: Chemically-Induced12Locked
Cardiomyopathy12Locked
Cardiovascular Diseases12Locked
Chemotherapy-Induced Kidney Damage12Locked
Chemotherapy-Induced Toxicity: Cyclophosphamide12Locked
Chemotherapy-Induced Toxicity: Gentamicin12Locked
Cognitive Decline/Dysfunction12Locked
Coronary Artery Disease12Locked
Delayed Sleep Phase Disorder12Locked
Diabetes: Memory Problems12Locked
Drug Toxicity: Isoprenaline12Locked
Drug Toxicity: Methotrexate12Locked
Endothelial Dysfunction12Locked
Gestational Hypertensive12Locked
Glaucoma22Locked
Hepatic Steatosis12Locked
High Fat Diet12Locked
Hydrogen Peroxide Induced Toxicity12Locked
Hypoxia12Locked
Infertility: Male12Locked
Kidney Damage: Chemically-Induced12Locked
Kidney Diseases12Locked
Learning disorders12Locked
Leishmaniasis22Locked
Liver Damage: Drug-Induced12Locked
Liver Injury: Ischemia/reperfusion 12Locked
Low Back Pain12Locked
Melanoma12Locked
Memory Disorders: Sleep Deprivation Induced12Locked
Metabolic Syndrome X12Locked
Middle Cerebral Artery Occlusion (MCAO)12Locked
Mycotoxin Toxicity12Locked
Myocardial Fibrosis 12Locked
Myocardial Ischemia12Locked
Nephropathy12Locked
Nicotine/Tobacco Toxicity 12Locked
Osteoarthritis12Locked
Osteoporosis12Locked
Ovarian Cancer22Locked
Pancreatitis12Locked
Periodontitis12Locked
Pesticide-Induced Toxicity: Organophosphates12Locked
Radiation12Locked
Respiratory Distress Syndrome12Locked
Schizophrenia12Locked
Traumatic Brain Injury12Locked
Acute lymphoblastic leukemia (ALL)11Locked
Aluminum Toxicity 11Locked
Aspergillosis11Locked
Autoimmune Diseases11Locked
Cancers: Drug Resistant11Locked
Cancers: Multi-Drug Resistant11Locked
Cardiotoxicity: Chemotherapy-Induced11Locked
Chronic Pain11Locked
Colon Cancer11Locked
Coronavirus Infection11Locked
Dementia11Locked
Dermatitis11Locked
Diabetic Retinopathy11Locked
Endothelial Damage11Locked
Epilepsy11Locked
Eye Diseases11Locked
HIV Infections11Locked
Helicobacter Pylori Infection11Locked
Herpes Simplex Virus Type 111Locked
Leukemia: Chronic myelogenous leukemia (CML) 11Locked
Lung Cancer11Locked
Macular Degeneration11Locked
Mitochondrial Dysfunction 11Locked
Oral Cancer11Locked
Plasmodium Infections11Locked
Prostate Cancer11Locked
Retinoblastoma11Locked
Skin Cancer11Locked
Smoking11Locked
Squamous cell carcinoma11Locked
Thyroid Cancer11Locked
80 Pharmacological Actions Researched for Crocin
NameACCKFocus
Antioxidants62118Locked
Anti-Inflammatory Agents5498Locked
Hypoglycemic Agents860Locked
Neuroprotective Agents3152Locked
Hypolipidemic443Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor1434Locked
Antidepressive Agents729Locked
Anti-Apoptotic1625Locked
Antiproliferative 1725Locked
Cardioprotective1425Locked
Hepatoprotective1224Locked
Anti-Anxiety Agents322Locked
Apoptotic1720Locked
Interleukin-6 Downregulation1119Locked
Nrf2 activation1018Locked
NF-kappaB Inhibitor1016Locked
Renoprotective816Locked
Interleukin-1 beta downregulation915Locked
Heme oxygenase-1 up-regulation813Locked
Anti-Fibrotic612Locked
Antihypertensive Agents212Locked
Insulin Sensitizers212Locked
Anti-metastatic710Locked
Chemopreventive710Locked
Interleukin-17 downregulation110Locked
MicroRNA modulator510Locked
Analgesics48Locked
Chemoprotective Agents48Locked
Pancreato Protective Agents48Locked
Malondialdehyde Down-regulation47Locked
Chemotherapeutic56Locked
Cytoprotective36Locked
Radioprotective36Locked
Radiosensitizer26Locked
Brain-derived neurotrophic factor modulator35Locked
Wnt/β-catenin signaling pathway modulation35Locked
Anticarcinogenic Agents34Locked
Bcl-2 protein down-regulation44Locked
Chemosensitizer44Locked
Cyclooxygenase 2 Inhibitors34Locked
Interleukin-4 downregulation24Locked
interleukin-13 down-regulation24Locked
Cell cycle arrest33Locked
Superoxide Dismutase Up-regulation23Locked
Angiogenesis Inducing Agents12Locked
Anti-Asthmatic Agents12Locked
Autophagy Inhibitors12Locked
Autophagy Up-regulation12Locked
Catalase Up-Regulation12Locked
Fertility Agents: Male12Locked
Gastroprotective12Locked
Immunomodulatory22Locked
Interferon Gamma Reducer12Locked
Interleukin-10 downregulation12Locked
Interleukin-5 downregulation12Locked
Matrix Metalloproteinase-7 (MMP-7) Inhibitor12Locked
Multidrug Resistance Gene Modulators22Locked
Osteoprotective 12Locked
Postaglandin PGE2 downregulation 22Locked
Prophylactic Agents12Locked
SIRT1 Activator12Locked
Telomerase Inhibitor22Locked
Transforming growth factor beta (TGF-β) inhibitor12Locked
Tumor Suppressor Protein p53 Upregulation22Locked
Vascular Endothelial Growth Factor A Enhancer12Locked
Angiogenesis Inhibitors11Locked
Angiotensin-Converting Enzyme Inhibitors11Locked
Anti-Bacterial Agents11Locked
Antineoplastic Agents11Locked
Antinoceceptive 11Locked
Antiparasitic Agents11Locked
Antiviral Agents11Locked
Caspase-3 Activation11Locked
Cyclin D1 Down-Regulation11Locked
Interleukin-12 downregulation11Locked
Leishmanicidal11Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor11Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor11Locked
STAT3 Inhibitor11Locked
Vasodilator Agents11Locked

View the Evidence:
276 Abstracts with Crocin Research

[+]

Effect of Crocus sativus and crocin in the treatment of patients with type-2 diabetes mellitus.Sep 28, 2023

Pubmed Data : J Ethnopharmacol. 2023 Sep 29 ;319(Pt 2):117255. Epub 2023 Sep 29. PMID: 37778521
Article Published Date : Sep 28, 2023
Study Type : Meta Analysis, Review
Additional Links
Substances : Crocin, Saffron
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Anticholesteremic Agents, Antihypertensive Agents, Hypoglycemic Agents
[+]

Saffron and crocin may modulate the serum lipid profile in patient with metabolic disorders.Feb 03, 2020

Pubmed Data : Arch Physiol Biochem. 2020 Feb 4:1-13. Epub 2020 Feb 4. PMID: 32013614
Article Published Date : Feb 03, 2020
Study Type : Meta Analysis, Review
Additional Links
Substances : Crocin, Saffron
Diseases : Hyperglycemia, Hyperlipidemia
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic
[+]

The effect of crocin supplementation on lipid concentrations and fasting blood glucose.Jul 31, 2020

Pubmed Data : Complement Ther Med. 2020 Aug ;52:102500. Epub 2020 Jul 11. PMID: 32951748
Article Published Date : Jul 31, 2020
Study Type : Meta Analysis, Review
Additional Links
Substances : Crocin
Diseases : Hypoglycemia
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic
[+]

Crocin considerably seems to be effective for relieving symptoms of CIPN in cancer patients receiving chemotherapy agents.Aug 10, 2021

Pubmed Data : J Ethnopharmacol. 2021 Aug 11 ;281:114511. Epub 2021 Aug 11. PMID: 34390797
Article Published Date : Aug 10, 2021
Study Type : Human Study
Additional Links
Substances : Crocin
Diseases : Chemotherapy-Induced Toxicity: Peripheral Neuropathy
Pharmacological Actions : Chemoprotective Agents, Neuroprotective Agents
[+]

The findings indicate that crocin supplementation can improve glycemic control and insulin resistance in patients with T2D.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Diabetol Metab Syndr. 2020 ;12:59. Epub 2020 Jul 9. PMID: 32670418
Article Published Date : Dec 31, 2019
Study Type : Human Study
Additional Links
Substances : Crocin
Diseases : Diabetes Mellitus: Type 2, Insulin Resistance
Pharmacological Actions : Antihypertensive Agents, Hypoglycemic Agents, Insulin Sensitizers
[+]

A pilot study of the effects of crocin on high-density lipoprotein cholesterol uptake capacity in patients with metabolic syndrome.Oct 04, 2021

Pubmed Data : Biofactors. 2021 Oct 5. Epub 2021 Oct 5. PMID: 34609029
Article Published Date : Oct 04, 2021
Study Type : Human Study
Additional Links
Substances : Crocin
Diseases : Metabolic Syndrome X
Pharmacological Actions : Anticholesteremic Agents
[+]

Crocin alleviates cognitive impairment associated with atherosclerosis.Jan 26, 2022

Pubmed Data : Phytother Res. 2022 Jan 27. Epub 2022 Jan 27. PMID: 35084779
Article Published Date : Jan 26, 2022
Study Type : Human Study
Additional Links
Substances : Crocin
Diseases : Atherosclerosis, Brain Inflammation , Cognitive Decline/Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Crocin can be considered for treatment of burning mouth syndrome.Oct 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2019 Nov-Dec;9(6):505-516. PMID: 31763210
Article Published Date : Oct 31, 2019
Study Type : Human Study
Additional Links
Substances : Crocin
Diseases : Anxiety, Burning Mouth Syndrome, Depression
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
[+]

Crocin can be effective in controlling the level of FBS and HbA1c in patients with type 2 diabetes.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Nutr ESPEN. 2022 08 ;50:255-263. Epub 2022 May 18. PMID: 35871933
Article Published Date : Dec 31, 2021
Study Type : Human Study
Additional Links
Substances : Crocin
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents
[+]

Crocin is effective in treatment of patients with mild to moderate OCD with possibly fewer adverse effects compared to fluoxetine.Feb 17, 2021

Pubmed Data : Hum Psychopharmacol. 2021 Feb 18:e2780. Epub 2021 Feb 18. PMID: 33599345
Article Published Date : Feb 17, 2021
Study Type : Human Study
Additional Links
Substances : Crocin
Diseases : Anxiety, Obsessive-Compulsive Disorder
Pharmacological Actions : Anti-Anxiety Agents
Additional Keywords : Natural Substances Versus Drugs
[+]

Crocin supplementation appears to effectively establish oxidant/antioxidant balance and improve inflammatory conditions in patients with COPD.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:884710. Epub 2022 Apr 20. PMID: 35517806
Article Published Date : Dec 31, 2021
Study Type : Human Study
Additional Links
Substances : Crocin
Diseases : Chronic Obstructive Lung Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Effect of crocin of Crocus sativus on serum inflammatory markers in chronic obstructive pulmonary disease patients.Jan 10, 2023

Pubmed Data : Br J Nutr. 2023 Jan 11:1-8. Epub 2023 Jan 11. PMID: 36628554
Article Published Date : Jan 10, 2023
Study Type : Human Study
Additional Links
Substances : Crocin
Diseases : Chronic Obstructive Pulmonary Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Effects of crocin supplementation on inflammatory markers, lipid profiles, insulin and cardioprotective indices in women with PCOS.May 31, 2022

Pubmed Data : Phytother Res. 2022 Jun ;36(6):2605-2615. Epub 2022 Apr 26. PMID: 35470916
Article Published Date : May 31, 2022
Study Type : Human Study
Additional Links
Substances : Crocin
Diseases : Insulin Resistance, Polycystic Ovary Syndrome
Pharmacological Actions : Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Evaluation of crocin effect on contrast-induced nephropathy following coronary angiography or angioplasty.Nov 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Pharm Res. 2022 Dec ;21(1):e126920. Epub 2022 Jun 14. PMID: 36060925
Article Published Date : Nov 30, 2022
Study Type : Human Study
Additional Links
Substances : Crocin
Diseases : Nephropathy
Pharmacological Actions : Renoprotective
[+]

Evaluation of therapeutic effects of crocin in attenuating the progression of diabetic nephropathy.Oct 07, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2022 Oct 8 ;22(1):262. Epub 2022 Oct 8. PMID: 36209091
Article Published Date : Oct 07, 2022
Study Type : Human Study
Additional Links
Substances : Carotenoids, Crocin
Diseases : Diabetes Mellitus: Type 2, Diabetic Nephropathy
Pharmacological Actions : Antioxidants, Transforming growth factor beta (TGF-β) inhibitor
[+]

Inflammatory markers response to crocin supplementation in patients with type 2 diabetes mellitus.Apr 14, 2021

Pubmed Data : Phytother Res. 2021 Apr 15. Epub 2021 Apr 15. PMID: 33856733
Article Published Date : Apr 14, 2021
Study Type : Human Study
Additional Links
Substances : Crocin
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Significant effect of crocin on the gene expression of MicroRNA-21 and MicroRNA-155 in patients with osteoarthritis.Jun 17, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Allergy Asthma Immunol. 2022 Jun 18 ;21(3):322-331. Epub 2022 Jun 18. PMID: 35822682
Article Published Date : Jun 17, 2022
Study Type : Human Study
Additional Links
Substances : Crocin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator
[+]

These results demonstrated the effect of crocin in depression and could be administered in treatment of MDD patients.Mar 14, 2015

Pubmed Data : J Affect Disord. 2015 Mar 15 ;174:51-6. Epub 2014 Nov 26. PMID: 25484177
Article Published Date : Mar 14, 2015
Study Type : Human Study
Additional Links
Substances : Carotenoids, Crocin, Saffron
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Phytotherapy
Problem Substances : Fluoxetine (trade name Prozac)
[+]

These results suggest the beneficial and therapeutic effects of crocin in multiple sclerosis.Oct 15, 2019

Pubmed Data : J Biochem Mol Toxicol. 2019 Oct 16:e22410. Epub 2019 Oct 16. PMID: 31617649
Article Published Date : Oct 15, 2019
Study Type : Human Study
Additional Links
Substances : Crocin
Diseases : Multiple Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-17 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin can be considered as a potential drug and sensitizer in cancer treatment. Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Pharm Res. 2017 ;16(1):230-237. PMID: 28496478
Article Published Date : Dec 31, 2016
Study Type : Human In Vitro
Additional Links
Substances : Crocin
Diseases : Head and Neck Cancer
Pharmacological Actions : Radiosensitizer
[+]

Pathogenesis and anti-proliferation mechanisms of crocin in human gastric carcinoma cells.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Pathol. 2020 ;13(5):912-922. Epub 2020 May 1. PMID: 32509062
Article Published Date : Dec 31, 2019
Study Type : Human In Vitro
Additional Links
Substances : Crocin
Diseases : Gastric Cancer
Pharmacological Actions : Antioxidants, Antiproliferative , Nrf2 activation
[+]

Crocin combined With cisplatin regulates proliferation, apoptosis and Emt of gastric cancer cells.Sep 14, 2023

Pubmed Data : Curr Cancer Drug Targets. 2023 Sep 15. Epub 2023 Sep 15. PMID: 37718528
Article Published Date : Sep 14, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Crocin
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Therapeutic effects of crocin alone or in combination with sorafenib against hepatocellular carcinoma.Aug 24, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2022 Aug 25 ;11(9). Epub 2022 Aug 25. PMID: 36139719
Article Published Date : Aug 24, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Crocin
Diseases : Liver Cancer
Pharmacological Actions : Chemoprotective Agents, Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Sorafenib
[+]

Crocin ameliorates oxidative stress and suppresses renal damage in streptozotocin induced diabetic male rats.Aug 23, 2020

Pubmed Data : Biotech Histochem. 2020 Aug 24:1-8. Epub 2020 Aug 24. PMID: 32835521
Article Published Date : Aug 23, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Matrix Metalloproteinase-7 (MMP-7) Inhibitor, Renoprotective
[+]

A natural carotenoid crocin exerts antidepressant action.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Adv Res. 2023 Jan ;43:219-231. Epub 2022 Mar 2. PMID: 36585110
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Carotenoids, Crocin
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Neurogenesis, Wnt/β-catenin signaling pathway modulation
[+]

Administering crocin ameliorates anxiety-like behaviors and reduces the inflammatory response in amyloid-beta induced neurotoxicity.Mar 07, 2021

Pubmed Data : Clin Exp Pharmacol Physiol. 2021 Mar 8. Epub 2021 Mar 8. PMID: 33686675
Article Published Date : Mar 07, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Anxiety, Brain Inflammation
Pharmacological Actions : Anti-Anxiety Agents, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Administration of crocin reduced d-galactose-induced aging.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2018 Jan-Feb;8(1):14-23. PMID: 29387570
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Aging
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ameliorative effect of crocin on sperm parameters and in vitro fertilization in mice under oxidative stress induced by paraquat.Dec 31, 2019

Pubmed Data : Int J Fertil Steril. 2020 Jan ;13(4):307-314. Epub 2019 Nov 11. PMID: 31710192
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Infertility: Male, Oxidative Stress, Pesticide Toxicity
Pharmacological Actions : Antioxidants
Problem Substances : Paraquat
[+]

Ameliorative effects of crocin against electromagnetic field-induced oxidative stress and liver and kidney injuries in mice.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2023 ;13(2):200-212. PMID: 37333475
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Kidney Damage, Liver Damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective
Anti Therapeutic Actions : Electromagnetic Field Harms
[+]

Ameliorative effects of crocin on paraquat-induced oxidative stress in testis.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Reprod Biomed (Yazd). 2019 Dec ;17(11):807-818. Epub 2019 Dec 26. PMID: 31911963
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Pesticide Toxicity , Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Malondialdehyde Down-regulation
Problem Substances : Paraquat
[+]

Ameliorative effects of crocin on tartrazine dye-induced pancreatic adverse effects.Aug 31, 2020

Pubmed Data : Environ Sci Pollut Res Int. 2020 Sep 1. Epub 2020 Sep 1. PMID: 32870427
Article Published Date : Aug 31, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Pancreato Protective Agents
Problem Substances : Tartrazine (Yellow Food Dye)
[+]

Anti-epileptic effect of crocin on experimental temporal lobe epilepsy.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:757729. Epub 2022 Mar 31. PMID: 35431921
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Epilepsy
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Anti-metastatic properties of a potent herbal combination in cell and mice models of triple negative breast cancer.Feb 14, 2020

Pubmed Data : Life Sci. 2020 Feb 15 ;243:117245. Epub 2020 Jan 8. PMID: 31926253
Article Published Date : Feb 14, 2020
Study Type : Animal Study
Additional Links
Substances : Crocetin, Crocin, Saffron
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone.Oct 11, 2019

Pubmed Data : Physiol Behav. 2019 Oct 12 ;212:112699. Epub 2019 Oct 12. PMID: 31614158
Article Published Date : Oct 11, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Brain Inflammation , Depression
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Antioxidants, Interleukin-1 beta downregulation
[+]

Antidepressant effect of crocin in mice with chronic mild stress. Aug 24, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2022 Aug 25 ;27(17). Epub 2022 Aug 25. PMID: 36080230
Article Published Date : Aug 24, 2022
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Antioxidants
[+]

Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice.Apr 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2018 May ;25(4):747-754. Epub 2016 Oct 13. PMID: 29740240
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Antioxidant and anti-inflammatory effects of crocin ameliorate doxorubicin-induced nephrotoxicity.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2021 ;2021:8841726. Epub 2021 Feb 15. PMID: 33628387
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Chemoprotective Agents, Renoprotective
[+]

Antioxidant and anti-inflammatory potential of crocin on the doxorubicin mediated hepatotoxicity.Sep 30, 2023

Pubmed Data : Tissue Cell. 2023 Oct ;84:102182. Epub 2023 Jul 26. PMID: 37523948
Article Published Date : Sep 30, 2023
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
[+]

Cognitive protective mechanism of crocin pretreatment in rat submitted to acute high-altitude hypoxia exposure.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2020 ;2020:3409679. Epub 2020 Jun 9. PMID: 32596298
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Altitude Sickness, Hypoxia
Pharmacological Actions : Neuroprotective Agents
[+]

Crocetin and crocin are potential natural biomedicines for the management of diseases associated with abnormal blood vessel growth.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:675359. Epub 2021 Apr 30. PMID: 33995106
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Crocetin, Crocin
Diseases : Macular Degeneration
Pharmacological Actions : Angiogenesis Inhibitors
[+]

Crocin administration could protect the liver damage induced by morphine.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Res Pharm Sci. 2016 Mar-Apr;11(2):120-9. PMID: 27168751
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Morphine
[+]

Crocin administration may reduce inflammation-driven tissue damage in patients with hemorrhagic shock.Apr 27, 2017

Pubmed Data : J Interferon Cytokine Res. 2017 Apr 28. Epub 2017 Apr 28. PMID: 28453369
Article Published Date : Apr 27, 2017
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Hemorrhagic Shock
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation, Interleukin-6 Downregulation
[+]

Crocin alleviates lipopolysaccharide-induced acute respiratory distress syndrome.Jan 09, 2020

Pubmed Data : Inflamm Res. 2020 Jan 10. Epub 2020 Jan 10. PMID: 31925528
Article Published Date : Jan 09, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Crocin
Diseases : Lipopolysaccharide-Induced Toxicity, Respiratory Distress Syndrome
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Crocin alleviates the inflammation and oxidative stress responses associated with diabetic nephropathy.Apr 25, 2021

Pubmed Data : Life Sci. 2021 Apr 26 ;278:119542. Epub 2021 Apr 26. PMID: 33915128
Article Published Date : Apr 25, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin ameliorates atherosclerosis.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Cycle. 2022 Jan ;21(2):202-218. Epub 2022 Jan 3. PMID: 34978526
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Atherosclerosis
Pharmacological Actions : Hypolipidemic
[+]

Crocin ameliorates atopic dermatitis symptoms by down regulation of the Th2 cells-mediated immune response.Nov 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Nov 2 ;10(11). Epub 2018 Nov 2. PMID: 30400140
Article Published Date : Nov 01, 2018
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Atopic Dermatitis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Crocin ameliorates chronic obstructive pulmonary disease-induced depression.Sep 02, 2019

Pubmed Data : Eur J Pharmacol. 2019 Sep 3 ;862:172640. Epub 2019 Sep 3. PMID: 31491407
Article Published Date : Sep 02, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Chronic Obstructive Pulmonary Disease, Depression
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, NF-kappaB Inhibitor
[+]

Crocin ameliorates depressive-like behaviors induced by chronic restraint stress.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neurochem Int. 2022 07 ;157:105343. Epub 2022 Apr 28. PMID: 35490894
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
[+]

Crocin ameliorates hepatic steatosis through activation of AMPK signalling.Jan 07, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lipids Health Dis. 2019 Jan 8 ;18(1):11. Epub 2019 Jan 8. PMID: 30621686
Article Published Date : Jan 07, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Hepatic Steatosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
[+]

Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation.Jul 31, 2019

Pubmed Data : Pharmacol Rep. 2019 Aug ;71(4):746-752. Epub 2019 Apr 16. PMID: 31220735
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Drug Toxicity: Methotrexate, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Methotrexate
[+]

Crocin ameliorates MicroRNAs-associated ER stress in type 2 diabetes induced by methylglyoxal.Jan 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2022 Feb ;25(2):179-186. PMID: 35655590
Article Published Date : Jan 31, 2022
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Malondialdehyde Down-regulation, MicroRNA modulator
[+]

Crocin and crocetin showed a significant protective effect against the N-methyl-N-nitrosourea induced breast cancer in rats.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell J. 2017 Apr-Jun;19(1):94-101. Epub 2016 Dec 21. PMID: 28367420
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Crocetin, Crocin
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

Crocin and crocetin significantly increased the total time of non-rapid eye movement (non-REM) sleep after the administration.Jan 31, 2012

Pubmed Data : Mol Nutr Food Res. 2012 Feb ;56(2):304-8. Epub 2011 Oct 28. PMID: 22038919
Article Published Date : Jan 31, 2012
Study Type : Animal Study
Additional Links
Substances : Carotenoids, Crocetin, Crocin, Saffron
Diseases : Delayed Sleep Phase Disorder, Insomnia, Sleep Disorders
Additional Keywords : Dose Response
[+]

Crocin and curcumin, either alone or in combination, can be a suitable treatment modality for rheumatoid arthritis.Apr 07, 2023

Pubmed Data : Curr Med Chem. 2023 Apr 8. Epub 2023 Apr 8. PMID: 37031388
Article Published Date : Apr 07, 2023
Study Type : Animal Study
Additional Links
Substances : Crocin, Curcumin
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin and Metformin suppress metastatic breast cancer progression.Apr 29, 2021

Pubmed Data : Mol Cell Biochem. 2021 Apr 30. Epub 2021 Apr 30. PMID: 33929675
Article Published Date : Apr 29, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Crocin
Diseases : Breast Cancer, Cancer Metastasis
Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Crocin and voluntary exercise promote heart angiogenesis through Akt and ERK1/2 signalling in type 2 diabetic rats.Dec 31, 2017

Pubmed Data : Bratisl Lek Listy. 2018 ;119(12):757-761. PMID: 30686014
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetes Mellitus: Type 2
Therapeutic Actions : Exercise
Pharmacological Actions : Angiogenesis Inducing Agents
[+]

Crocin as a novel therapeutic agent against colitis.Feb 02, 2019

Pubmed Data : Drug Chem Toxicol. 2019 Feb 3:1-8. Epub 2019 Feb 3. PMID: 30714419
Article Published Date : Feb 02, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Crocin as a potential candidate to prevent anxiety and depressive-like behaviors.Nov 19, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neurosci Lett. 2022 Nov 20 ;791:136912. Epub 2022 Oct 13. PMID: 36244518
Article Published Date : Nov 19, 2022
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Anxiety, Depression
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
[+]

Crocin at a dose of 60 mg/kg for six weeks could be effective in preventing nitrosative stress in hemiparkinsonian rats.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Malays J Med Sci. 2016 Nov ;23(6):35-43. Epub 2016 Dec 7. PMID: 28090177
Article Published Date : Oct 31, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Crocin attenuates CCl 4-induced liver fibrosis via PPAR-γ mediated modulation of inflammation and fibrogenesis in rats.Nov 30, 2020

Pubmed Data : Hum Exp Toxicol. 2020 Dec ;39(12):1639-1649. Epub 2020 Jul 7. PMID: 32633567
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Transforming growth factor beta (TGF-β) inhibitor
[+]

Crocin attenuates cyclophosphamide induced testicular toxicity by preserving glutathione redox system.Apr 30, 2018

Pubmed Data : Biomed Pharmacother. 2018 May ;101:174-180. Epub 2018 Feb 24. PMID: 29486335
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Anti-Apoptotic
[+]

Crocin attenuates inflammation of lung tissue in ovalbumin-sensitized mice.Nov 30, 2021

Pubmed Data : Biofactors. 2021 Dec 1. Epub 2021 Dec 1. PMID: 34856021
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Crocin attenuates isoprenaline-induced myocardial fibrosis.Aug 06, 2019

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 Aug 7. Epub 2019 Aug 7. PMID: 31392383
Article Published Date : Aug 06, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Drug Toxicity: Isoprenaline, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Crocin attenuates lung inflammation and pulmonary vascular dysfunction in a rat model of bleomycin-induced pulmonary fibrosis.Aug 25, 2019

Pubmed Data : Life Sci. 2019 Aug 26:116794. Epub 2019 Aug 26. PMID: 31465731
Article Published Date : Aug 25, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin attenuates metabolic syndrome-induced osteoporosis.Jun 30, 2019

Pubmed Data : J Food Biochem. 2019 Jul ;43(7):e12895. Epub 2019 May 15. PMID: 31353703
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Metabolic Syndrome X, Osteoporosis
Pharmacological Actions : Osteoprotective
[+]

Crocin attenuates osteoarthritis symptoms through alleviating oxidative stress and inflammation.Aug 06, 2017

Pubmed Data : Inflammation. 2017 Aug 7. Epub 2017 Aug 7. PMID: 28785878
Article Published Date : Aug 06, 2017
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, NF-kappaB Inhibitor
[+]

Crocin attenuates oxidative and inflammatory stress-related periodontitis in cardiac tissues.May 10, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Adv Clin Exp Med. 2021 May 11. Epub 2021 May 11. PMID: 33974754
Article Published Date : May 10, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Crocin attenuates oxidative stress and inflammation in myocardial infarction induced by isoprenaline.Nov 30, 2020

Pubmed Data : J Diabetes Metab Disord. 2020 Dec ;19(2):1517-1525. Epub 2020 Nov 18. PMID: 33553037
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Myocardial Infarction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Crocin can improve oxidative stress in pancreatic cells by potentiating the anti-oxidant defense system.May 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacopuncture. 2019 Jun ;22(2):83-89. Epub 2019 Jun 30. PMID: 31338247
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetes: Oxidative Stress, Hyperglycemia
Pharmacological Actions : Antioxidants, Pancreato Protective Agents
[+]

Crocin can improve the synaptic loss and neuronal death.Jun 09, 2020

Pubmed Data : J Chem Neuroanat. 2020 Jun 10:101837. Epub 2020 Jun 10. PMID: 32534024
Article Published Date : Jun 09, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Crocin combined with voluntary exercise improved insulin resistance and reduced glucose levels in diabetic rats.Apr 18, 2016

Pubmed Data : J Endocrinol Invest. 2016 Apr 19. Epub 2016 Apr 19. PMID: 27094045
Article Published Date : Apr 18, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetes Mellitus: Type 2, Hyperglycemia, Insulin Resistance
Therapeutic Actions : Exercise, Integrative Medicine
Pharmacological Actions : Hypoglycemic Agents, Vascular Endothelial Growth Factor A Enhancer
[+]

Crocin contributed to the alleviation of some complications of diabetes.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biol Res (Thessalon). 2020 Dec ;27:4. Epub 2020 Mar 2. PMID: 32161725
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective
[+]

Crocin could attenuate hyperalgesia induced by sleep deprivation.Apr 30, 2020

Pubmed Data : Basic Clin Neurosci. 2020 May-Jun;11(3):261-267. Epub 2020 May 1. PMID: 32963719
Article Published Date : Apr 30, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Hyperalgesia, Insomnia, Sleep Disorders
Pharmacological Actions : Analgesics
[+]

Crocin could be potentially used as an adjuvant treatment in combination with Dox to reduce cardiotoxicity.Dec 31, 2020

Pubmed Data : Adv Exp Med Biol. 2021 ;1328:143-153. PMID: 34981476
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Carotenoids, Crocin
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents
[+]

Crocin could contribute to the development of phytotherapeutic approaches in the treatment of obesity and diabetes.Nov 16, 2016

Pubmed Data : Turk J Med Sci. 2016 Nov 17 ;46(5):1593-1602. Epub 2016 Nov 17. PMID: 27966333
Article Published Date : Nov 16, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetes Mellitus: Type 2, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin could improve kidney function in diabetic conditions.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2023 ;13(2):189-199. PMID: 37333473
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Renoprotective, Transforming growth factor beta (TGF-β) inhibitor
[+]

Crocin could significantly decrease the side effects caused by cyclophosphamide chemotherapy in mice ovarian tissue.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Vet Res Forum. 2021 ;12(2):217-222. Epub 2021 Jun 15. PMID: 34345389
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Chemoprotective Agents
[+]

Crocin demonstrates good prospects in the treatment of Alzheimer's disease through the oxidative stress associated apoptosis signalling pathway.Dec 17, 2018

Pubmed Data : Int J Mol Med. 2018 Dec 18. Epub 2018 Dec 18. PMID: 30569175
Article Published Date : Dec 17, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Crocin
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
[+]

Crocin exhibits an antihypertensive effect in a rat model of gestational hypertension and activates the Nrf-2/HO-1 signaling pathway.Jan 12, 2021

Pubmed Data : Hypertens Res. 2021 Jan 13. Epub 2021 Jan 13. PMID: 33442028
Article Published Date : Jan 12, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Gestational Hypertensive, Hypertension
Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Crocin had a superior effect compared to sitagliptin on blood sugar level, β-islets diameter and insulin immune-reactivity.Jul 30, 2019

Pubmed Data : Environ Toxicol Pharmacol. 2019 Jul 31 ;72:103238. Epub 2019 Jul 31. PMID: 31394428
Article Published Date : Jul 30, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hypoglycemic Agents
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Crocin has a cardioprotective effect against DOX-induced cardiomayopathy.Mar 04, 2016

Pubmed Data : Chem Biol Interact. 2016 Mar 5 ;247:39-48. Epub 2016 Jan 22. PMID: 26807765
Article Published Date : Mar 04, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Crocin has a paradoxical protective effect by regulating both the induction and inhibition of autophagy in ischemia and reperfusion injury.Apr 23, 2016

Pubmed Data : Am J Chin Med. 2016 Apr 24:1-16. Epub 2016 Apr 24. PMID: 27109157
Article Published Date : Apr 23, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Myocardial Ischemia
Pharmacological Actions : Autophagy Inhibitors, Autophagy Up-regulation, Cardioprotective
[+]

Crocin has a protective effect of on gastric mucosal lesions induced by ischemia-reperfusion injury in rats.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Pharm Res. 2016 ;15(Suppl):93-99. PMID: 28228808
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Ischemia
Pharmacological Actions : Gastroprotective
[+]

Crocin has a protective effect on diabetes induced oxidative stress in testicular tissue.Dec 31, 2020

Pubmed Data : Adv Exp Med Biol. 2021 ;1308:273-281. PMID: 33861450
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetes: Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation
[+]

Crocin has a renoprotective effects against the development of oxidative stress and inflammation in the kidney of old rats.Jun 08, 2016

Pubmed Data : Phytother Res. 2016 Jun 9. Epub 2016 Jun 9. PMID: 27279282
Article Published Date : Jun 08, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Kidney Damage, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective
[+]

Crocin has a role in attenuation of induced ulcerative colitis in rats.Jan 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Feb ;110:389-399. Epub 2018 Dec 5. PMID: 30530041
Article Published Date : Jan 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Ulcerative Colitis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation
[+]

Crocin has anti-inflammatory and protective effects in ischemia-reperfusion induced renal injuries.Jun 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2017 Jul ;20(7):753-759. PMID: 28852439
Article Published Date : Jun 30, 2017
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Ischemia, Kidney Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective
[+]

Crocin has exerted neuroprotective effects in the rat model of MK-801-elicited schizophrenia.Sep 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Compr Psychiatry. 2020 Sep 30 ;103:152209. Epub 2020 Sep 30. PMID: 33045669
Article Published Date : Sep 29, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Schizophrenia
Pharmacological Actions : Brain-derived neurotrophic factor modulator, Neuroprotective Agents
[+]

Crocin has potential for use as a therapuetic strategy in the treatment of lower back pain. Oct 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2015 Nov ;36(5):1291-9. Epub 2015 Sep 30. PMID: 26648423
Article Published Date : Oct 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Crocin
Diseases : Low Back Pain
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Crocin has protective activities against ethanol toxic effects in the liver and kidney.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2020 Jan ;23(1):51-62. PMID: 32405348
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Alcohol Toxicity , Alcoholic Liver Disease, Chemically-Induced Liver Damage, Kidney Damage: Chemically-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin has protective effects against gentamicin-induced nephrotoxicity in rats.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2016 Mar ;19(3):337-43. PMID: 27114805
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents
[+]

Crocin improved memory under unpredictable stress conditions.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Adv Biomed Res. 2018 ;7:137. Epub 2018 Oct 24. PMID: 30464937
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Anxiety, Memory Disorders
[+]

Crocin improves cognitive behavior in rats with Alzheimer's disease.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2019 ;2019:9454913. Epub 2019 Aug 26. PMID: 31534969
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Crocin improves diabetes-induced oxidative stress.Dec 31, 2020

Pubmed Data : Adv Exp Med Biol. 2021 ;1328:275-285. PMID: 34981484
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Carotenoids, Crocin
Diseases : Diabetes: Oxidative Stress
Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation
[+]

Crocin improves insulin sensitivity and ameliorates adiposity.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2020 ;2020:9136282. Epub 2020 Jun 6. PMID: 32596392
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Insulin Resistance, Obesity
Pharmacological Actions : Insulin Sensitizers
Additional Keywords : Anti-Obesity Agents
[+]

Crocin improves nicotine-induced adverse effects on reproductive parameters in male mice.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Fertil Steril. 2016 Apr-Jun;10(1):71-8. Epub 2016 Apr 5. PMID: 27123203
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Nicotine/Tobacco Toxicity
Pharmacological Actions : Cytoprotective, Fertility Agents: Male
[+]

Crocin improves spatial learning and memory deficits in diabetic rats.Jan 26, 2017

Pubmed Data : Neurosci Lett. 2017 Jan 27 ;642:1-6. Epub 2017 Jan 27. PMID: 28137647
Article Published Date : Jan 26, 2017
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetes: Memory Problems, Diabetic Complications
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Crocin improves the renal autophagy in rat experimental membranous nephropathy.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ren Fail. 2023 ;45(2):2253924. Epub 2023 Sep 19. PMID: 37724538
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Nephropathy
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective, SIRT1 Activator
[+]

Crocin induced caspase mediated MCF-7 cell death.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2016 ;17(3):1499-506. PMID: 27039797
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Crocin
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
[+]

Crocin induces autophagic cell death and inhibits cell invasion of cervical cancer SiHa cells through activation of PI3K/AKT.Aug 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Transl Med. 2020 Sep ;8(18):1180. PMID: 33241029
Article Published Date : Aug 31, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Cervical Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

Crocin inhibits beta amyloid induced apoptosis, which is possibly associated with its antioxidant properties.Nov 30, 2015

Pubmed Data : Pharmacol Biochem Behav. 2015 Dec ;139(Pt A):47-58. Epub 2015 Oct 17. PMID: 26484504
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Alzheimer's Disease, Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Crocin inhibits KBTBD7 to prevent excessive inflammation and cardiac dysfunction following myocardial infarction.Dec 31, 2022

Pubmed Data : Mol Med Rep. 2023 Jan ;27(1). Epub 2022 Dec 9. PMID: 36484363
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Myocardial Infarction
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin inhibits obesity via AMPK-dependent inhibition of adipocyte differentiation and promotion of lipolysis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Trends. 2018 ;12(6):587-594. PMID: 30674760
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents
[+]

Crocin inhibits the type 2 inflammatory response produced by ILC2s in eosinophilic nasal polyps.Jul 08, 2023

Pubmed Data : Am J Rhinol Allergy. 2023 Jul 9:19458924231185296. Epub 2023 Jul 9. PMID: 37424236
Article Published Date : Jul 08, 2023
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetes Mellitus: Type 2, Inflammation, Nasal Polyps
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Crocin is a candidate chemopreventive agent against hepatocellular carcinoma.Oct 31, 2015

Pubmed Data : Recent Pat Anticancer Drug Discov. 2015 Nov 1. Epub 2015 Nov 1. PMID: 26522014
Article Published Date : Oct 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Crocin, Saffron
Diseases : Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Chemopreventive
[+]

Crocin is protective against cardiovascular-related disorders produced by doxorubicin.Jun 09, 2016

Pubmed Data : Life Sci. 2016 Jun 10. Epub 2016 Jun 10. PMID: 27297631
Article Published Date : Jun 09, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Cardioprotective, Chemoprotective Agents
[+]

Crocin lessens desipramine-induced phospholipidosis biomarker levels.Apr 23, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Biomed. 2023 Apr 24 ;94(2):e2023141. Epub 2023 Apr 24. PMID: 37092612
Article Published Date : Apr 23, 2023
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Tricyclic Antidepressant (TCA)
[+]

Crocin may be a promising therapeutic agent for preventing and improving diabetes-related kidney disease.Jan 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Turk J Med Sci. 2023 Feb ;53(1):10-18. Epub 2023 Feb 22. PMID: 36945919
Article Published Date : Jan 31, 2023
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Antioxidants, Renoprotective
[+]

Crocin may exert antiapoptotic, antioxidant and protective effects in IR-mediated brain injury induced by four-vessel occlusion.Apr 22, 2016

Pubmed Data : Life Sci. 2016 Apr 23. Epub 2016 Apr 23. PMID: 27117584
Article Published Date : Apr 22, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
[+]

Crocin may exert potent anti- rheumatoid arthritis effects through inhibiting cytokines.Apr 30, 2017

Pubmed Data : Biosci Biotechnol Biochem. 2017 May ;81(5):891-898. PMID: 28388359
Article Published Date : Apr 30, 2017
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Inflammation, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin may exhibit significant melanoma tumor remission properties by positively modulating tumor growth related parameters.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2017 03 1 ;18(3):841-846. Epub 2017 Mar 1. PMID: 28441796
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Melanoma
Pharmacological Actions : Chemotherapeutic
[+]

Crocin may have beneficial effects on coronary artery disease patients.Dec 02, 2019

Pubmed Data : Phytother Res. 2019 Dec 3. Epub 2019 Dec 3. PMID: 31797473
Article Published Date : Dec 02, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Coronary Artery Disease, Lipid Peroxidation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, SIRT1 Activator
[+]

Crocin may have improvement effects on cholestasis-induced neuroinflammation in the rat's striatum.May 20, 2021

Pubmed Data : Metab Brain Dis. 2021 May 21. Epub 2021 May 21. PMID: 34019207
Article Published Date : May 20, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Crocin may have therapeutic potential in various NLRP3 inflammasome-related inflammatory diseases.Mar 02, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Curr Issues Mol Biol. 2023 Mar 3 ;45(3):2090-2104. Epub 2023 Mar 3. PMID: 36975504
Article Published Date : Mar 02, 2023
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Inflammation, Peritonitis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Crocin may play a protective role in MCT-induced PAH rats by alleviating inflammatory response.Dec 01, 2021

Pubmed Data : Am J Chin Med. 2021 Dec 2:1-19. Epub 2021 Dec 2. PMID: 34931588
Article Published Date : Dec 01, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Hypertension: Pulmonary
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Crocin mediated amelioration of oxidative burden and inflammatory cascade suppresses diabetic nephropathy progression in diabetic rats.Mar 24, 2018

Pubmed Data : Chem Biol Interact. 2018 Mar 25 ;284:90-100. Epub 2018 Feb 3. PMID: 29409856
Article Published Date : Mar 24, 2018
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetes: Oxidative Stress, Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation
[+]

Crocin or related antioxidants may protect against cerebral ischemia.Dec 31, 2016

Pubmed Data : Restor Neurol Neurosci. 2017 ;35(1):65-75. PMID: 28059805
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Cerebral Ischemia
Pharmacological Actions : Neuroprotective Agents
[+]

Crocin possesses hepatoprotective effects against BPA-induced liver toxicity.Jul 04, 2017

Pubmed Data : Food Chem Toxicol. 2017 Jul 5. Epub 2017 Jul 5. PMID: 28689058
Article Published Date : Jul 04, 2017
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Bisphenol Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective, MicroRNA modulator
Additional Keywords : Antioxidants, Bisphenol Toxicity, Crocin, Hepatoprotective, MicroRNA modulator
Problem Substances : Bisphenol A
[+]

Crocin potentiates the suppressive effects of sorafenib on tumor growth.Aug 10, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancers (Basel). 2023 Aug 11 ;15(16). Epub 2023 Aug 11. PMID: 37627094
Article Published Date : Aug 10, 2023
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Chemosensitizer, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Additional Keywords : Chemothapeutic Synergy: Sorafenib
[+]

Crocin protected the liver against IR injury through increasing the activity of antioxidant enzymes.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2017 ;2017:1702967. Epub 2017 Mar 6. PMID: 28367266
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Carotenoids, Crocin
Diseases : Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Antioxidants, Hepatoprotective, MicroRNA modulator, Nrf2 activation
[+]

Crocin protects against genotoxic stress induced by gamma radiation, urethane and procarbazine in mice.Dec 31, 2016

Pubmed Data : Hum Exp Toxicol. 2017 Jan 1:960327116689715. Epub 2017 Jan 1. PMID: 28111973
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : DNA damage
Pharmacological Actions : Cytoprotective, Radioprotective
Anti Therapeutic Actions : Radiotherapy
[+]

Crocin protects the liver and kidney from patulin-induced apoptosis.Feb 08, 2016

Pubmed Data : Environ Sci Pollut Res Int. 2016 Feb 9. Epub 2016 Feb 9. PMID: 26856859
Article Published Date : Feb 08, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Mycotoxin Toxicity
Pharmacological Actions : Hepatoprotective, Renoprotective
[+]

Crocin recovered spatial learning and memory defects induced by BPA.Aug 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2020 Sep ;23(9):1146-1154. PMID: 32963736
Article Published Date : Aug 31, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Bisphenol Toxicity
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Bisphenol A
[+]

Crocin reduced the toxic effects of diazinon by inhibiting apoptosis in aortic tissue.Jun 30, 2016

Pubmed Data : Toxicol Ind Health. 2016 Jul ;32(7):1237-45. Epub 2014 Nov 20. PMID: 27353299
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Pesticide-Induced Toxicity: Organophosphates
Pharmacological Actions : Anti-Apoptotic, Cytoprotective
Problem Substances : Organophosphates
[+]

Crocin restrained the activation of hepatic stellate cells through the lnc-LFAR1/MTF-1/GDNF axis, thereby ameliorating liver fibrosis.Dec 08, 2020

Pubmed Data : Cell Cycle. 2020 Dec 9:1-11. Epub 2020 Dec 9. PMID: 33295246
Article Published Date : Dec 08, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Crocin reverses depression-like behaviour in Parkinson disease.Jun 02, 2020

Pubmed Data : Mol Neurobiol. 2020 Jun 3. Epub 2020 Jun 3. PMID: 32495180
Article Published Date : Jun 02, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Depression, Parkinson's Disease
Pharmacological Actions : Antidepressive Agents
[+]

Crocin showed a significant protective effect against allergic asthma progression.Aug 31, 2017

Pubmed Data : Int Immunopharmacol. 2017 Sep ;50:305-312. Epub 2017 Jul 21. PMID: 28738246
Article Published Date : Aug 31, 2017
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Allergic Airway Diseases, Asthma
Pharmacological Actions : Anti-Inflammatory Agents, interleukin-13 down-regulation, Interleukin-4 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin showed promising neuroprotective effects in rotenone-induced Parkinson's disease.Dec 03, 2019

Pubmed Data : Neuropharmacology. 2019 Dec 4:107900. Epub 2019 Dec 4. PMID: 31811872
Article Published Date : Dec 03, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Parkinson's Disease
Pharmacological Actions : MicroRNA modulator, Neuroprotective Agents
Problem Substances : Rotenone
[+]

Crocin significantly decreased chronic constriction injury-induced neuropathic pain.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ScientificWorldJournal. 2020 ;2020:4046256. Epub 2020 Nov 25. PMID: 33299384
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Neuropathic Pain
Pharmacological Actions : Analgesics
[+]

Crocin supplementation may help reduce oxidative damage to periodontal tissues.Apr 14, 2019

Pubmed Data : Biotech Histochem. 2019 Apr 15:1-8. Epub 2019 Apr 15. PMID: 30982354
Article Published Date : Apr 14, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Periodontitis
Pharmacological Actions : Antioxidants
[+]

Crocin suppressed atrophic change of the pancreas by decrease of LOX-1 and RAGE mRNA expression in diabetic rats.Sep 17, 2019

Pubmed Data : J Complement Integr Med. 2019 Sep 18. Epub 2019 Sep 18. PMID: 31532754
Article Published Date : Sep 17, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : MicroRNA modulator, Pancreato Protective Agents
[+]

Crocin treatment exerts anti-inflammatory and anti-oxidative effects in liver tissue damage of pinealectomized diabetic rats.Feb 05, 2023

Pubmed Data : Environ Sci Pollut Res Int. 2023 Feb 6. Epub 2023 Feb 6. PMID: 36746856
Article Published Date : Feb 05, 2023
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetic Complications, Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Crocin has significant analgesic effects that are probably mediated by an endocannabinoid mechanism.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Pharmacol. 2020 ;12:97-106. Epub 2020 Apr 28. PMID: 32431552
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Neuropathic Pain
Pharmacological Actions : Analgesics
Additional Keywords : Endocannabinoid System
[+]

Crocin, a constituent of Saffron, can significantly reduce infarcted areas caused by occlusion of the middle cerebral artery (MCA) in mice.Apr 01, 2007

Pubmed Data : Biochim Biophys Acta. 2007 Apr;1770(4):578-84. Epub 2006 Dec 5. PMID: 17215084
Article Published Date : Apr 01, 2007
Study Type : Animal Study
Additional Links
Substances : Carotenoids, Crocin, Saffron
Diseases : Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Crocin, an active constituent of Crocus sativus ameliorates cerulein induced pancreatic inflammation and oxidative stress.Nov 24, 2019

Pubmed Data : Phytother Res. 2019 Nov 25. Epub 2019 Nov 25. PMID: 31769107
Article Published Date : Nov 24, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Pancreatitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Pancreato Protective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin, may be useful agents for the prevention of renal ischemia-reperfusion (IR)-induced oxidative injury in rats.Jan 01, 2005

Pubmed Data : J Pharm Pharm Sci. 2005;8(3):387-93. Epub 2005 Aug 22. PMID: 16401388
Article Published Date : Jan 01, 2005
Study Type : Animal Study
Additional Links
Substances : Carotenoids, Crocin, Saffron
Diseases : Kidney Diseases
[+]

Crocin-I protects against high-fat diet-induced obesity.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:894089. Epub 2022 Aug 11. PMID: 36034852
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : High Fat Diet, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents
Additional Keywords : Anti-Obesity Agents
[+]

Crocin: a protective natural antioxidant against pulmonary fibrosis induced by bleomycin.Jan 28, 2020

Pubmed Data : Pharmacol Rep. 2020 Jan 29. Epub 2020 Jan 29. PMID: 31997260
Article Published Date : Jan 28, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Chemoprotective Agents
[+]

Dietary crocin is protective in pancreatic cancer while reducing radiation-induced hepatic oxidative damage.Jan 25, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 06 26 ;12(6). Epub 2020 Jun 26. PMID: 32604971
Article Published Date : Jan 25, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Liver Damage, Pancreatic Cancer, Radiation
Pharmacological Actions : Radioprotective
[+]

Effects of crocin on spatial or aversive learning and memory impairments induced by lipopolysaccharide.Dec 31, 2020

Pubmed Data : Avicenna J Phytomed. 2021 Jan-Feb;11(1):79-90. PMID: 33628722
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Learning disorders, Lipopolysaccharide-Induced Toxicity, Memory Disorders
Pharmacological Actions : Neuroprotective Agents
[+]

Effects of crocin on T-bet/GATA-3 ratio, and miR-146a and miR-106a expression levels in lung tissue of ovalbumin-sensitized mice.Sep 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2022 Oct ;25(10):1267-1274. PMID: 36311189
Article Published Date : Sep 30, 2022
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator
[+]

Exercise and crocin prevent adolescent-stress induced impairment of spatial navigation and dendritic retraction in the hippocampal CA3 area.Feb 28, 2021

Pubmed Data : Brain Res. 2021 Mar 1 ;1754:147274. Epub 2021 Jan 7. PMID: 33422526
Article Published Date : Feb 28, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Cognitive Decline/Dysfunction
Therapeutic Actions : Exercise
Pharmacological Actions : Brain-derived neurotrophic factor modulator, Neuroprotective Agents
[+]

Feeding crocin ameliorate cognitive dysfunction, oxidative stress and neuroinflammation induced by unpredictable chronic mild stress.Jul 31, 2023

Pubmed Data : Inflammopharmacology. 2023 Aug ;31(4):2079-2090. Epub 2023 Jun 1. PMID: 37261629
Article Published Date : Jul 31, 2023
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Memory Disorders, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Hepatoprotective effects of carvedilol and crocin against leflunomide-induced liver injury.Nov 30, 2022

Pubmed Data : Int Immunopharmacol. 2022 Dec ;113(Pt A):109297. Epub 2022 Oct 14. PMID: 36252480
Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Chemically-Induced Liver Damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
[+]

In vivo and in vitro efficacy of crocin against Echinococcus multilocularis.Jul 12, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Parasit Vectors. 2021 Jul 13 ;14(1):364. Epub 2021 Jul 13. PMID: 34256821
Article Published Date : Jul 12, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Crocin
Diseases : Echinococcosis
Pharmacological Actions : Antiparasitic Agents
[+]

Inhibitory effect of crocin against gastric carcinoma via regulating TPM4 gene.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2021 ;14:111-122. Epub 2021 Jan 7. PMID: 33442270
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Crocin
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Gene Expression Regulation
[+]

Integrating serum metabolomics and network analysis to explore the antidepressant activity of crocin.Nov 30, 2023

Pubmed Data : Pharm Biol. 2023 Dec ;61(1):1414-1430. PMID: 37688460
Article Published Date : Nov 30, 2023
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
[+]

Investigating the effect of crocin on memory deficits induced by total sleep deprivation.Apr 24, 2021

Pubmed Data : J Psychopharmacol. 2021 Apr 25:2698811211000762. Epub 2021 Apr 25. PMID: 33899577
Article Published Date : Apr 24, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Memory Disorders: Sleep Deprivation Induced
Pharmacological Actions : Neuroprotective Agents
[+]

Investigation of the ability of crocin to treat skin cancer.Apr 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cureus. 2023 May ;15(5):e38596. Epub 2023 May 5. PMID: 37284388
Article Published Date : Apr 30, 2023
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Skin Cancer
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Mechanistic insights on the effect of crocin on atherosclerosis.Jul 31, 2022

Pubmed Data : Coron Artery Dis. 2022 Aug 1 ;33(5):394-402. Epub 2022 Mar 8. PMID: 35880561
Article Published Date : Jul 31, 2022
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Atherosclerosis
Pharmacological Actions : Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]

Neuroprotective effects of crocin against ethanol neurotoxicity in the animal model of fetal alcohol spectrum disorders.Jan 16, 2022

Pubmed Data : Neurochem Res. 2022 Jan 17. Epub 2022 Jan 17. PMID: 35040027
Article Published Date : Jan 16, 2022
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Fetal Alcoholism
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Neuroprotective effects of crocin and crocin-loaded niosomes against the paraquat-induced oxidative brain damage in rats.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Open Life Sci. 2022 ;17(1):1174-1181. Epub 2022 Sep 14. PMID: 36185402
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Brain: Oxidative Stress, Pesticide Toxicity
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Paraquat
[+]

Prophylactic neuroprotective propensity of crocin against rotenone induced neurotoxicity.Jun 17, 2019

Pubmed Data : Metab Brain Dis. 2019 Jun 18. Epub 2019 Jun 18. PMID: 31214956
Article Published Date : Jun 17, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Rotenone
[+]

Protective effect of crocin against mitochondrial damage and memory deficit induced by beta-amyloid.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Pharm Res. 2021 ;20(2):79-94. PMID: 34567148
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Protective effect of crocin and voluntary exercise against oxidative stress in the heart of high-fat diet-induced type 2 diabetic rats.Nov 30, 2016

Pubmed Data : Physiol Int. 2016 Dec ;103(4):459-468. PMID: 28229629
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetes: Oxidative Stress, Diabetes Mellitus: Type 2, High Fat Diet
Therapeutic Actions : Exercise
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Protective effect of crocin on cuprizone-induced model of multiple sclerosis in mice.Feb 19, 2023

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2023 Feb 20. Epub 2023 Feb 20. PMID: 36805765
Article Published Date : Feb 19, 2023
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Multiple Sclerosis
Pharmacological Actions : Antioxidants, Glutathione Peroxidase 1 (GPx1) Up-Regulation, Superoxide Dismutase Up-regulation
[+]

Protective effect of crocin on electromagnetic field-induced testicular damage.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2020 Jan ;23(1):102-110. PMID: 32395207
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : DNA damage
Pharmacological Actions : Radioprotective
Anti Therapeutic Actions : Electromagnetic Field Harms
[+]

Protective effect of crocin on liver function and survival in rats with traumatic hemorrhagic shock.Apr 30, 2021

Pubmed Data : J Surg Res. 2021 May ;261:301-309. Epub 2021 Jan 20. PMID: 33482612
Article Published Date : Apr 30, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Hemorrhagic Shock
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Protective effect of crocin on malathion-induced cardiotoxicity.Dec 31, 2020

Pubmed Data : Iran J Pharm Res. 2021 ;20(2):156-172. PMID: 34567153
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Pesticide Toxicity
Pharmacological Actions : Antioxidants, Cardioprotective
Problem Substances : Pesticides
[+]

Protective effects of crocin against hepatic damages in D-galactose aging model.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Pharm Res. 2020 ;19(3):440-450. PMID: 33680043
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Aging: Liver, Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
[+]

Protective effects of crocin against methotrexate-induced hepatotoxicity.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cureus. 2023 Jan ;15(1):e34468. Epub 2023 Jan 31. PMID: 36874671
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Hepatoprotective, Superoxide Dismutase Up-regulation
[+]

Protective effects of crocin and gallic acid on the liver damage.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gastroenterol Hepatol Bed Bench. 2023 ;16(1):499-508. PMID: 37070111
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Crocin, Gallic Acid
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective
[+]

Protective effects of crocin on acrylamide-induced testis damage.Jul 25, 2021

Pubmed Data : Andrologia. 2021 Jul 26:e14176. Epub 2021 Jul 26. PMID: 34309867
Article Published Date : Jul 25, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Acrylamide-induced toxicity, Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants
Problem Substances : Acrylamide
[+]

Protective effects of quercetin and crocin in the kidneys and liver of obese Sprague-Dawley rats with Type 2 diabetes.Oct 05, 2020

Pubmed Data : Hum Exp Toxicol. 2020 Oct 6:960327120954521. Epub 2020 Oct 6. PMID: 33021114
Article Published Date : Oct 05, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin, Quercetin
Diseases : Diabetes Mellitus: Type 2, Kidney Damage, Obesity
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic, Renoprotective
[+]

Protective role of crocin against sepsis-induced injury in the liver, kidney and lungs.Nov 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2022 Dec ;60(1):543-552. PMID: 35225146
Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Sepsis
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Hepatoprotective, NF-kappaB Inhibitor, Renoprotective
[+]

Saffron (Crocus sativus) aqueous extract and its constituent crocin reduces stress-induced anorexia in mice.Dec 01, 2011

Pubmed Data : Phytother Res. 2011 Dec ;25(12):1833-8. Epub 2011 Apr 19. PMID: 21503997
Article Published Date : Dec 01, 2011
Study Type : Animal Study
Additional Links
Substances : Crocin, Saffron
Diseases : Anorexia: Stress-Induced
Additional Keywords : Plant Extracts
[+]

Saffron and crocin ameliorate prenatal valproic acid-induced autistic-like behaviors and brain oxidative stress in the male offspring rats.Sep 30, 2023

Pubmed Data : Metab Brain Dis. 2023 Oct ;38(7):2231-2241. Epub 2023 Aug 11. PMID: 37566156
Article Published Date : Sep 30, 2023
Study Type : Animal Study
Additional Links
Substances : Crocin, Saffron
Diseases : Autism Spectrum Disorders, Oxidative Stress
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Glutathione Upregulation
[+]

Saffron and its active constituent crocin can prevent chronic stress-induced oxidative stress damage of the brain, liver and kidneys.Nov 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Adv Pharm Bull. 2014 Dec ;4(Suppl 2):493-9. Epub 2014 Dec 31. PMID: 25671180
Article Published Date : Nov 30, 2014
Study Type : Animal Study
Additional Links
Substances : Crocin, Saffron
Diseases : Brain: Oxidative Stress, Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Saffron carotenoids reversed the unpredictable chronic mild stress-induced depression and anxiety.Sep 30, 2023

Pubmed Data : Phytomedicine. 2023 Oct ;119:154989. Epub 2023 Jul 20. PMID: 37506574
Article Published Date : Sep 30, 2023
Study Type : Animal Study
Additional Links
Substances : Crocetin, Crocin, Saffron
Diseases : Anxiety, Depression
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
Problem Substances : Fluoxetine (trade name Prozac)
[+]

Saffron extract and crocin exert anti-inflammatory and anti-oxidative effects in a repetitive mild traumatic brain injury mouse model.Jan 22, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2022 03 23 ;12(1):5004. Epub 2022 Mar 23. PMID: 35322143
Article Published Date : Jan 22, 2022
Study Type : Animal Study
Additional Links
Substances : Crocin, Saffron
Diseases : Brain Injury: Traumatic
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Saffron extract and crocin supplements have hepatoprotective effect against non-alcoholic fatty liver disease and HFD-induced liver damage.Oct 21, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2016 Oct 22 ;16(1):401. Epub 2016 Oct 22. PMID: 27770798
Article Published Date : Oct 21, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin, Saffron
Diseases : Liver Damage, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
Additional Keywords : Plant Extracts
[+]

Saffron may be exploited as a supplementary therapeutic agent in PD and other oxidative stress mediated neurodegenerative conditions.Dec 16, 2015

Pubmed Data : Neurotoxicology. 2015 Dec 17 ;52:230-242. Epub 2015 Dec 17. PMID: 26705857
Article Published Date : Dec 16, 2015
Study Type : Insect Study
Additional Links
Substances : Crocin, Saffron
Diseases : Neurodegenerative Diseases, Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Saffron stigma extract and crocin play an important neuroprotective role in therapeutic measures against benzo[a]pyrene-induced behavioral alterations.Aug 29, 2023

Pubmed Data : Drug Chem Toxicol. 2023 Aug 30:1-12. Epub 2023 Aug 30. PMID: 37649374
Article Published Date : Aug 29, 2023
Study Type : Animal Study
Additional Links
Substances : Crocin, Saffron
Diseases : Benzo[a]pyrene-induced Toxicity
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Benzo(a)pyrene
[+]

Synergistic effects of exosomal crocin or curcumin compounds and HPV L1-E7 polypeptide vaccine construct on tumor eradication in C57BL/6 mouse model.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2021 ;16(10):e0258599. Epub 2021 Oct 14. PMID: 34648579
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Carotenoids, Crocin, Curcumin
Diseases : Cervical Cancer, Human Papillomavirus (HPV)
Pharmacological Actions : Immunomodulatory
Additional Keywords : Natural Substance Synergy
[+]

The active constituents of C. Sativus L. crocins might play a role in compulsive behaviour.Oct 17, 2012

Pubmed Data : Neurosci Lett. 2012 Oct 18 ;528(1):27-30. Epub 2012 Sep 7. PMID: 22985509
Article Published Date : Oct 17, 2012
Study Type : Animal Study
Additional Links
Substances : Carotenoids, Crocin, Saffron
Diseases : Obsessive-Compulsive Disorder
Additional Keywords : Phytotherapy, Plant Extracts
[+]

The anti-diabetic and anti-diabetic nephritic effects of crocin were related to its modulation of oxidative stress-mediated NF-κB signalling.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:541. Epub 2020 Apr 30. PMID: 32425787
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation, Hypoglycemic Agents, NF-kappaB Inhibitor, Renoprotective, Superoxide Dismutase Up-regulation
[+]

The aqueous extract of saffron and crocin can be considered as safe agents and reliable alternative to diazepam in management of ethanol withdrawal syndrome.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacopuncture. 2018 Dec ;21(4):277-283. Epub 2018 Dec 31. PMID: 30652054
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Crocin, Saffron
Diseases : Alcohol Withdrawal
Pharmacological Actions : Prophylactic Agents
[+]

The effect of crocin on cholestasis-induced spatial memory impairment.Feb 19, 2023

Pubmed Data : Metab Brain Dis. 2023 Feb 20. Epub 2023 Feb 20. PMID: 36807082
Article Published Date : Feb 19, 2023
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Memory Disorders
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Neuroprotective Agents
[+]

The effect of triptolide combined with crocin on arthritis.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:908227. Epub 2022 Jun 23. PMID: 35814255
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin, Triptolide
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Gene Expression Regulation
[+]

The protection of crocin against ulcerative colitis and colorectal cancer. Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:639458. Epub 2021 Mar 18. PMID: 33841156
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Colitis, Colorectal Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, NF-kappaB Inhibitor
[+]

The protective effect of crocin against testicular toxicity induced by ionizing radiation.Aug 23, 2023

Pubmed Data : Environ Toxicol. 2023 Aug 24. Epub 2023 Aug 24. PMID: 37615252
Article Published Date : Aug 23, 2023
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Radiation
Pharmacological Actions : Radioprotective
[+]

The protective effect of crocin on cisplatin-induced testicular impairment in rats.Aug 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Urol. 2021 Sep 1 ;21(1):117. Epub 2021 Sep 1. PMID: 34470647
Article Published Date : Aug 31, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants, Chemoprotective Agents
[+]

The results of the present study showed neuroprotective effects of crocin, safranal and insulin in a rat model of diabetic neuropathy.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2015 Sep-Oct;5(5):469-78. PMID: 26468467
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Crocin, Safranal
Diseases : Diabetic Nephropathy
Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Neuroprotective Agents
[+]

The results suggest that combined therapy with crocin and exercise may be protective for motor and memory deficits in Parkinson's disease patients.Dec 31, 2018

Pubmed Data : Metab Brain Dis. 2019 04 ;34(2):459-468. Epub 2019 Jan 16. PMID: 30652256
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Brain: Oxidative Stress, Memory Disorders, Parkinson's Disease
Therapeutic Actions : Exercise
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

The study concludes that crocin can alleviate the toxic effect of chlorpyrifos caused by oxidative stress on cardiac muscle.Apr 30, 2019

Pubmed Data : Acta Histochem. 2019 May ;121(4):472-483. Epub 2019 Apr 9. PMID: 30975443
Article Published Date : Apr 30, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin, Saffron
Diseases : Pesticide Toxicity
Pharmacological Actions : Antioxidants, Cardioprotective
Problem Substances : Chlorpyrifos
[+]

These findings suggest crocin as a promising complementary antimetastatic herbal medicine for treatment of triple-negative breast cancer.Oct 22, 2018

Pubmed Data : DNA Cell Biol. 2018 Oct 23. Epub 2018 Oct 23. PMID: 30351203
Article Published Date : Oct 22, 2018
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Wnt/β-catenin signaling pathway modulation
[+]

These observations suggest that both diosmin and crocin alleviate metabolic syndrome and the associated nephropathy.May 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Jun ;102:930-937. Epub 2018 Apr 5. PMID: 29710548
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Crocin, Diosmin
Diseases : Hypertension, Inflammation, Insulin Resistance, Nephropathy, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results demonstrated that the suppression of crocin on airway inflammation and hyper-reactivity in a murine model.May 31, 2015

Pubmed Data : Immunopharmacol Immunotoxicol. 2015 Jun ;37(3):236-43. Epub 2015 Mar 10. PMID: 25753844
Article Published Date : May 31, 2015
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Asthma, Inflammation
Pharmacological Actions : Anti-Asthmatic Agents, Anti-Inflammatory Agents, interleukin-13 down-regulation, Interleukin-4 downregulation, Interleukin-5 downregulation
[+]

These results suggest that crocin has neuroprotective effects against traumatic brain injury in mice.Mar 29, 2015

Pubmed Data : Neurosci Lett. 2015 Mar 30 ;591:53-8. Epub 2015 Feb 11. PMID: 25681620
Article Published Date : Mar 29, 2015
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

These results suggested that crocin-I effectively alleviated depression-like behavior.Oct 31, 2020

Pubmed Data : J Affect Disord. 2020 Nov 1 ;276:476-486. Epub 2020 Jul 18. PMID: 32871679
Article Published Date : Oct 31, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Gut-brain Axis
[+]

This study elucidates the mechanism by which crocin alleviates neuropathic pain.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Plast. 2020 ;2020:4297483. Epub 2020 Jan 11. PMID: 32399022
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Hyperalgesia, Neuropathic Pain, Rheumatoid Arthritis
Pharmacological Actions : Analgesics, Wnt/β-catenin signaling pathway modulation
[+]

This study reveals that crocin improves myocardial infarction-induced impairments in cardiac function.Mar 29, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int Heart J. 2018 Mar 30 ;59(2):387-393. Epub 2018 Feb 23. PMID: 29479012
Article Published Date : Mar 29, 2018
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Myocardial Infarction, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Treatment with crocin may lead to a significant prevention of nitrate tolerance and endothelial dysfunction.Feb 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2020 Mar ;23(3):303-310. PMID: 32440316
Article Published Date : Feb 29, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Endothelial Dysfunction, Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation
[+]

Treatment with crocin may represent a novel approach for treating diabetic cardiomyopathy.Aug 31, 2018

Pubmed Data : Nutr Metab Cardiovasc Dis. 2018 Sep ;28(9):952-961. Epub 2018 Jul 14. PMID: 30017436
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Cardiomyopathy, Diabetic Complications
Pharmacological Actions : Cardioprotective
[+]

Treatment with crocin suppresses diabetic nephropathy progression.Oct 28, 2021

Pubmed Data : Chem Biol Interact. 2021 Oct 29 ;351:109733. Epub 2021 Oct 29. PMID: 34743986
Article Published Date : Oct 28, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Antioxidants, Renoprotective
[+]

Voluntary exercise and diet supplementation with crocin could have beneficial effects in prevention of cardiovascular disease.Jun 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arq Bras Cardiol. 2017 Jun 29:0. Epub 2017 Jun 29. PMID: 28678929
Article Published Date : Jun 28, 2017
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Cardiovascular Diseases
Therapeutic Actions : Exercise
Pharmacological Actions : Cardioprotective, MicroRNA modulator
Additional Keywords : Cardioprotective, Cardiovascular Diseases, Crocin, exercise, MicroRNA modulator
[+]

Crocin: A fighter against inflammation and pain.Jul 04, 2020

Pubmed Data : Food Chem Toxicol. 2020 Jul 5 ;143:111521. Epub 2020 Jul 5. PMID: 32640351
Article Published Date : Jul 04, 2020
Study Type : Review
Additional Links
Substances : Crocin
Diseases : Chronic Pain, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive , NF-kappaB Inhibitor
[+]

A combination of crocin and hyperthermia has strong antiproliferative and apoptotic activities against breast cancer cells.Mar 21, 2016

Pubmed Data : DNA Cell Biol. 2016 Mar 22. Epub 2016 Mar 22. PMID: 27003728
Article Published Date : Mar 21, 2016
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Breast Cancer
Therapeutic Actions : Heat Therapy, Integrative Medicine
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

A comparative study on anti-invasion, antimigration, and anti-adhesion effects of the bioactive carotenoids of saffron on 4T1 breast cancer cells.Jul 31, 2018

Pubmed Data : DNA Cell Biol. 2018 Aug ;37(8):697-707. Epub 2018 Jul 3. PMID: 29969282
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Crocetin, Crocin, Saffron
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Wnt/β-catenin signaling pathway modulation
[+]

A comprehensive review on anticancer mechanisms of crocin.Jul 02, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharm Pharmacol. 2017 Jul 3. Epub 2017 Jul 3. PMID: 28675431
Article Published Date : Jul 02, 2017
Study Type : Review
Additional Links
Substances : Crocin
Diseases : Cancers: All
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Chemotherapeutic, Telomerase Inhibitor
Additional Keywords : Anti-metastatic, Antiproliferative, Apoptotic, Cancers: All, Chemotherapeutic, Crocin, Telomerase Inhibitor
[+]

A review of the therapeutic effects of crocin in autoimmune diseases.Aug 19, 2019

Pubmed Data : Biofactors. 2019 Aug 20. Epub 2019 Aug 20. PMID: 31430413
Article Published Date : Aug 19, 2019
Study Type : Review
Additional Links
Substances : Crocin
Diseases : Asthma, Autoimmune Diseases, Diabetes Mellitus: Type 1, Multiple Sclerosis, Rheumatoid Arthritis, Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Ameliorative effects of crocin on the inflammation and oxidative stress-induced kidney damages by experimental periodontitis in rat.May 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2021 Jun ;24(6):825-832. PMID: 34630960
Article Published Date : May 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Antiangiogenic effect of crocin on breast cancer cell MDA-MB-231.Oct 31, 2019

Pubmed Data : J Thorac Dis. 2019 Nov ;11(11):4464-4473. PMID: 31903234
Article Published Date : Oct 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Angiogenesis Inhibitors, Apoptotic, Cell cycle arrest
Additional Keywords : Dose Response
[+]

Beneficial effects of crocin against depression.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2020 ;2020:3903125. Epub 2020 Jun 24. PMID: 32685478
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
[+]

Chemo-preventive effect of crocin against experimentally-induced hepatocarcinogenesis.Sep 13, 2020

Pubmed Data : Environ Toxicol Pharmacol. 2020 Sep 14 ;80:103494. Epub 2020 Sep 14. PMID: 32942000
Article Published Date : Sep 13, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Chemopreventive, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Combination of caffeic acid phenethyl ester and crocin realign potential molecular markers in U87-MG glioma cells.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Curr Ther Res Clin Exp. 2023 ;98:100695. Epub 2023 Feb 14. PMID: 36936719
Article Published Date : Dec 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Caffeic acid phenethyl ester, Crocin
Diseases : Glioma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Crocetin and crocin decreased cholesterol and triglyceride content of both breast cancer tumors and cell lines.Jun 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2020 Jul-Aug;10(4):384-397. PMID: 32850295
Article Published Date : Jun 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocetin, Crocin
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Chemotherapeutic, Hypolipidemic
[+]

Crocetin and crocin from saffron in cancer chemotherapy and chemoprevention.Dec 29, 2018

Pubmed Data : Anticancer Agents Med Chem. 2018 Dec 30. Epub 2018 Dec 30. PMID: 30599111
Article Published Date : Dec 29, 2018
Study Type : Review
Additional Links
Substances : Crocetin, Crocin, Saffron
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive, Chemotherapeutic
[+]

Crocetin and crocins activate different mechanisms involved in the vasoconstriction pathway in hypertension.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2015 ;20(9):17570-84. Epub 2015 Sep 22. PMID: 26402666
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Crocetin, Crocin, Saffron
Diseases : Hypertension
Pharmacological Actions : Vasodilator Agents
Additional Keywords : Plant Extracts
[+]

Crocin alleviates neurotoxicity induced by bupivacaine in SH-SY5Y cells with inhibition of PI3K/AKT signaling.Jul 30, 2023

Pubmed Data : Genes Genomics. 2023 Jul 31. Epub 2023 Jul 31. PMID: 37523128
Article Published Date : Jul 30, 2023
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Surgery: Anesthesiology
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation
Problem Substances : Bupivacaine
[+]

Crocin ameliorates arsenic trioxide‑induced cardiotoxicity.Sep 09, 2020

Pubmed Data : Biomed Pharmacother. 2020 Sep 10 ;131:110713. Epub 2020 Sep 10. PMID: 32920515
Article Published Date : Sep 09, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Cardiotoxicity: Chemotherapy-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Arsenic Trioxide
[+]

Crocin and paclitaxel and crocin and gamma radiation had synergistic effect on MCF-7 cell line to get more significant apoptosis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Breast Cancer. 2015 ;2015:139349. Epub 2015 Nov 26. PMID: 26693354
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Radiosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Crocin and picrocrocin could be a promising anti-HSV and anti-HIV agent for herbal therapy against viral infections.Dec 31, 2017

Pubmed Data : Curr Drug Deliv. 2018 ;15(5):698-704. PMID: 29189153
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Herpes Simplex Virus Type 1, HIV Infections
Pharmacological Actions : Antiviral Agents
Additional Keywords : Plant Extracts
[+]

Crocin and safranal exerted apoptotic effects in KB cell line.Jul 17, 2017

Pubmed Data : Nutr Cancer. 2017 Jul 18:1-9. Epub 2017 Jul 18. PMID: 28718677
Article Published Date : Jul 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Crocin, Safranal
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Apoptotic
[+]

Crocin attenuates NF-κB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ.Dec 31, 2021

Pubmed Data : Cytokine. 2022 06 ;154:155888. Epub 2022 Apr 18. PMID: 35447530
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Breast Cancer, Inflammation
Pharmacological Actions : Antiproliferative , NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin can be suggested as a promising therapy for ischemic cerebrovascular accidents.Jul 28, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Jul 29 ;130:110543. Epub 2020 Jul 29. PMID: 32738637
Article Published Date : Jul 28, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Crocin can be used as a suitable clinical agent for the treatment of T-lineage acute lymphoblastic leukaemia.Apr 17, 2016

Pubmed Data : West Indian Med J. 2016 Apr 18. Epub 2016 Apr 18. PMID: 27398676
Article Published Date : Apr 17, 2016
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Acute lymphoblastic leukemia (ALL)
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Dose Response
[+]

Crocin can significantly inhibit the growth of HO-8910 cells and arrest them in the G0/G1 phase.Jan 31, 2015

Pubmed Data : Nat Prod Commun. 2015 Feb ;10(2):249-52. PMID: 25920253
Article Published Date : Jan 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
[+]

Crocin could suppress drug resistance via down regulation of MRP transporters in the human ovarian cancer resistant cell line.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Daru. 2016 ;24(1):17. Epub 2016 Jun 24. PMID: 27342070
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Multidrug Resistance Gene Modulators
[+]

Crocin exerts anti-proliferative and apoptotic effects on cutaneous squamous cell carcinoma.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bioengineered. 2021 Dec ;12(1):4569-4580. PMID: 34320900
Article Published Date : Nov 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Crocin has pharmacological effects against the pathological behavior of colon cancer cells by interacting with the STAT3 signaling pathway.Jan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2020 Feb ;19(2):1297-1303. Epub 2019 Dec 16. PMID: 32010302
Article Published Date : Jan 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Colon Cancer
Pharmacological Actions : Chemotherapeutic, STAT3 Inhibitor
[+]

Crocin has therapeutic and preventive effects on cancer cell lines.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2020 Jan ;23(1):3-12. PMID: 32405344
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : Crocin
Diseases : Breast Cancer, Colorectal Cancer, Leukemia: Chronic myelogenous leukemia (CML) , Pancreatic Cancer, Prostate Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Cyclin D1 Down-Regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Telomerase Inhibitor
[+]

Crocin improves endothelial mitochondrial dysfunction.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Dev Biol. 2021 ;9:651434. Epub 2021 Mar 12. PMID: 33777959
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Mitochondrial Dysfunction
Pharmacological Actions : Antioxidants
[+]

Crocin increases gastric cancer cells' sensitivity to doxorubicin.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2020 07 1 ;21(7):1959-1967. Epub 2020 Jul 1. PMID: 32711421
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Gastric Cancer
Pharmacological Actions : Chemosensitizer, Multidrug Resistance Gene Modulators
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Crocin induces ROS-mediated papillary thyroid cancer cell apoptosis.Jan 14, 2022

Pubmed Data : Toxicol Appl Pharmacol. 2022 02 15 ;437:115892. Epub 2022 Jan 25. PMID: 35085590
Article Published Date : Jan 14, 2022
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Thyroid Cancer
Pharmacological Actions : Apoptotic, MicroRNA modulator
[+]

Crocin inhibited cell proliferation mainly by disrupting the microtubule network.Mar 23, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Mar 24 ;7:44984. Epub 2017 Mar 24. PMID: 28337976
Article Published Date : Mar 23, 2017
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative
[+]

Crocin inhibits angiogenesis and metastasis in colon cancer. Jan 28, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2022 04 29 ;11(9). Epub 2022 Apr 29. PMID: 35563808
Article Published Date : Jan 28, 2022
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Colon Cancer
Pharmacological Actions : Anti-metastatic, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Crocin inhibits oxidative stress and pro-inflammatory response of microglial cells associated with diabetic retinopathy. Mar 31, 2017

Pubmed Data : J Mol Neurosci. 2017 Apr ;61(4):581-589. Epub 2017 Feb 25. PMID: 28238066
Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Diabetic Retinopathy
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Crocin inhibits proliferation and induces apoptosis through suppressing MYCN expression in retinoblastoma.Jan 22, 2019

Pubmed Data : J Biochem Mol Toxicol. 2019 Jan 23:e22292. Epub 2019 Jan 23. PMID: 30672053
Article Published Date : Jan 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Retinoblastoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Crocin inhibits the migration, invasion, and epithelial-mesenchymal transition of gastric cancer cells.Mar 08, 2019

Pubmed Data : J Cell Physiol. 2019 Mar 9. Epub 2019 Mar 9. PMID: 30851060
Article Published Date : Mar 08, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Gastric Cancer
Pharmacological Actions : Anti-metastatic
[+]

Crocin is a potent water-soluble antioxidant with potential in therapy for Alzheimer's disease.Jan 30, 2017

Pubmed Data : J Agric Food Chem. 2017 Jan 31. Epub 2017 Jan 31. PMID: 28098452
Article Published Date : Jan 30, 2017
Study Type : Review
Additional Links
Substances : Crocin
Diseases : Alzheimer's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Crocin is proposed as a potentially powerful antioxidant to treat the cardiotoxicity caused by aluminum phosphide poisoning.Jan 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharm Pharmacol. 2021 Feb 1. Epub 2021 Feb 1. PMID: 33793778
Article Published Date : Jan 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Aluminum Toxicity , Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective
Problem Substances : Aluminum
[+]

Crocin may be useful to prevent or treatment of alcohol induced neurodegeneration and neurobehavioral sequels.Feb 28, 2019

Pubmed Data : Med Hypotheses. 2019 Mar ;124:21-25. Epub 2019 Jan 24. PMID: 30798909
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Alcohol Toxicity , Neurodegenerative Diseases
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Brain-derived neurotrophic factor modulator, Neuroprotective Agents
[+]

Crocin may serve as a good alternative/coadjuvant to vincristine in EBV-associated B-cell lymphoproliferative disorders.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediterr J Hematol Infect Dis. 2021 ;13(1):e2021049. Epub 2021 Jul 1. PMID: 34276918
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Lymphoma
Pharmacological Actions : Apoptotic, Chemotherapeutic
[+]

Crocin mitigates dichlorvos-induced oxidative stress and apoptosis in HCT-116 cells.Jul 31, 2016

Pubmed Data : Biomed Pharmacother. 2016 Aug ;82:65-71. Epub 2016 May 6. PMID: 27470340
Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Lipid Peroxidation, Oxidative Stress, Pesticide Toxicity
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Superoxide Dismutase Up-regulation
Problem Substances : Dichlorvos, Pesticides
[+]

Crocin promotes apoptosis of human skin cancer cells.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Dec ;16(6):5079-5084. Epub 2018 Oct 16. PMID: 30542463
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Skin Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Crocin protected against MNNG-induced malignant transformation.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Gastrointest Oncol. 2020 Dec ;11(6):1242-1252. PMID: 33456997
Article Published Date : Nov 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Gastric Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antioxidants, Chemopreventive, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Crocin protects against beta-amyloid peptide-induced apoptosis in PC12 cells via PI3 K pathway.Oct 11, 2020

Pubmed Data : Curr Mol Pharmacol. 2020 Oct 12. Epub 2020 Oct 12. PMID: 33045973
Article Published Date : Oct 11, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Crocin protects cardiomyocytes against lipopolysaccharide-Induced inflammation.Jul 29, 2019

Pubmed Data : Pharmacol Rep. 2019 Jul 30 ;71(6):1228-1234. Epub 2019 Jul 30. PMID: 31670059
Article Published Date : Jul 29, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin protects cardiomyocytes against lipopolysaccharide-induced inflammation.Oct 31, 2019

Pubmed Data : Pharmacol Rep. 2019 Nov ;71(6):1228-1234. Epub 2019 Jul 30. PMID: 32002862
Article Published Date : Oct 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin protects retinal ganglion cells against H2O2-induced damage.Dec 31, 2015

Pubmed Data : Int J Mol Med. 2016 Jan ;37(1):225-32. Epub 2015 Nov 23. PMID: 26718031
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Glaucoma
Pharmacological Actions : Anti-Apoptotic
[+]

Crocin reduces A. fumigatus-induced airway inflammation and NF-κB signal activation.Aug 07, 2017

Pubmed Data : J Cell Biochem. 2017 Aug 8. Epub 2017 Aug 8. PMID: 28786504
Article Published Date : Aug 07, 2017
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Aspergillosis, Chronic Obstructive Pulmonary Disease
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Crocin regulates the proliferation and migration of neural stem cells after cerebral ischemia.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Folia Neuropathol. 2020 ;58(3):201-212. PMID: 33099290
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Crocin significantly suppressed the proliferation of human lung adenocarcinoma cells and enhanced the chemo sensitivity.Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Transl Lung Cancer Res. 2015 Dec ;4(6):775-83. PMID: 26798587
Article Published Date : Nov 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin, Dose Response
[+]

Crocin suppresses breast cancer cell proliferation.Jun 30, 2023

Pubmed Data : Environ Toxicol. 2023 Jul ;38(7):1597-1608. Epub 2023 Mar 29. PMID: 36988377
Article Published Date : Jun 30, 2023
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative
[+]

Crocin treatment promotes the oxidative stress and apoptosis in human thyroid cancer cells.Sep 03, 2020

Pubmed Data : J Biochem Mol Toxicol. 2020 Sep 4:e22608. Epub 2020 Sep 4. PMID: 32886819
Article Published Date : Sep 03, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Thyroid Cancer
Pharmacological Actions : Apoptotic
[+]

Crocins for ischemic stroke: A review of current evidence. Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:825842. Epub 2022 Aug 5. PMID: 35991882
Article Published Date : Dec 31, 2021
Study Type : Review
Additional Links
Substances : Crocin
Diseases : Stroke: Ischemic
Pharmacological Actions : Neuroprotective Agents
[+]

Curative effects of crocin in ulcerative colitis via modulating apoptosis and inflammation.Apr 30, 2023

Pubmed Data : Int Immunopharmacol. 2023 May ;118:110138. Epub 2023 Apr 6. PMID: 37030122
Article Published Date : Apr 30, 2023
Study Type : In Vitro Study
Additional Links
Substances : Carotenoids, Crocin
Diseases : Inflammation, Ulcerative Colitis
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Evaluation of apoptotic effect of crocin, cisplatin, and their combination in human oral squamous cell carcinoma cell line HN5.Dec 31, 2020

Pubmed Data : Dent Res J (Isfahan). 2021 ;18:70. Epub 2021 Aug 18. PMID: 34584648
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Apoptotic, Chemoprotective Agents
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Immunomodulatory and anti-inflammatory potential of crocin in COVID-19 treatment.Apr 03, 2021

Pubmed Data : J Food Biochem. 2021 Apr 4:e13718. Epub 2021 Apr 4. PMID: 33817822
Article Published Date : Apr 03, 2021
Study Type : Review
Additional Links
Substances : Crocin
Diseases : Coronavirus Infection
Pharmacological Actions : Angiotensin-Converting Enzyme Inhibitors, Anti-Inflammatory Agents, Antioxidants, Immunomodulatory, Nrf2 activation
[+]

Immunoregulatory and anti-inflammatory properties of Crocus sativus and its main active constituentsMar 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2019 Apr ;22(4):334-344. PMID: 31223464
Article Published Date : Mar 31, 2019
Study Type : Review
Additional Links
Substances : Crocetin, Crocin, Saffron
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Immunomodulatory, Interleukin-12 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor
[+]

In vitro antileishmanial effects of saffron compounds, crocin and stigmasterol, on Iranian strain of Leishmania major.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Parasitol. 2021 Jan-Mar;16(1):151-158. PMID: 33786057
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocin, Saffron, Stigmasterol
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Natural carotenoids as neuroprotective agents for Alzheimer's disease.Dec 07, 2022

Pubmed Data : J Agric Food Chem. 2022 Dec 8. Epub 2022 Dec 8. PMID: 36480951
Article Published Date : Dec 07, 2022
Study Type : Review
Additional Links
Substances : Astaxanthin, Carotenoids, Crocin, Fucoxanthin
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Neuroprotective mechanism of crocin via PI3K/Akt/mTOR signaling pathway after cerebral infarction.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2022 ;14(5):3164-3171. Epub 2022 May 15. PMID: 35702067
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Stroke
Pharmacological Actions : Antioxidants, Autophagy Inhibitors, Neuroprotective Agents
[+]

Novel neuroprotective potential of crocin in neurodegenerative disorders.Sep 16, 2020

Pubmed Data : Neurochem Res. 2020 Sep 17. Epub 2020 Sep 17. PMID: 32940861
Article Published Date : Sep 16, 2020
Study Type : Review
Additional Links
Substances : Crocin
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Orally administered crocin protects against cerebral ischemia/reperfusion injury.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:440. Epub 2019 Apr 30. PMID: 31114499
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Cerebral Ischemia
Pharmacological Actions : Neuroprotective Agents
[+]

Protective effects of saffron and its active components against oxidative stress and apoptosis in endothelial cells.Dec 31, 2017

Pubmed Data : Microvasc Res. 2018 07 ;118:82-89. Epub 2018 Mar 7. PMID: 29524452
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Carotenoids, Crocin, Saffron, Safranal
Diseases : Endothelial Damage, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants
Additional Keywords : Plant Extracts
[+]

Retinoprotective effects of crocin and crocetin via anti-angiogenic mechanism in high glucose-induced human retinal pigment epithelium cells.Apr 18, 2021

Pubmed Data : Curr Mol Pharmacol. 2021 Apr 19. Epub 2021 Apr 19. PMID: 33881975
Article Published Date : Apr 18, 2021
Study Type : In Vitro Study
Additional Links
Substances : Crocetin, Crocin
Diseases : Diabetic Retinopathy
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Natural Substances Versus Drugs
[+]

ROS-sensitive Crocin-loaded chitosan microspheres for lung targeting and attenuation of radiation-induced lung injury.Apr 30, 2023

Pubmed Data : Carbohydr Polym. 2023 May 1 ;307:120628. Epub 2023 Jan 28. PMID: 36781279
Article Published Date : Apr 30, 2023
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Lung Damage, Radiation
Pharmacological Actions : Antioxidants, Radioprotective
[+]

Saffron and its can be effective in preventing and treating diseases caused by abnormal α-Synuclein aggregation.Dec 31, 2017

Pubmed Data : J Nat Med. 2018 Jan ;72(1):274-279. Epub 2017 Nov 17. PMID: 29147836
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Crocin, Saffron
Diseases : Dementia, Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Saffron and its main component crocin might be a promising target for cognition improvement in Alzheimer's disease and stress-related disorders.Nov 20, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Nov 21 ;133:110995. Epub 2020 Nov 21. PMID: 33232931
Article Published Date : Nov 20, 2020
Study Type : Review
Additional Links
Substances : Crocin, Saffron
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Saffron and its main ingredients such as crocin could be a potential candidate for the treatment of ocular disease.May 05, 2020

Pubmed Data : Curr Neuropharmacol. 2020 May 6. Epub 2020 May 6. PMID: 32379589
Article Published Date : May 05, 2020
Study Type : Review
Additional Links
Substances : Crocin, Saffron
Diseases : Eye Diseases, Glaucoma, Macular Degeneration
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Saffron bioactives crocin, crocetin and safranal: effect on oxidative stress and mechanisms of action.Dec 23, 2020

Pubmed Data : Crit Rev Food Sci Nutr. 2020 Dec 24:1-18. Epub 2020 Dec 24. PMID: 33356506
Article Published Date : Dec 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocetin, Crocin, Saffron, Safranal
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation
[+]

Synergistic anticancer effects of crocin combined with deuterium-depleted water on HT-29 cells.Feb 23, 2023

Pubmed Data : Anticancer Drugs. 2023 Feb 24. Epub 2023 Feb 24. PMID: 36847076
Article Published Date : Feb 23, 2023
Study Type : In Vitro Study
Additional Links
Substances : Crocin, Water: Deuterium Depleted
Pharmacological Actions : Antiproliferative , Cell cycle arrest
Additional Keywords : Natural Substance Synergy
[+]

Synergistic anticancer effects of curcumin and crocin on human colorectal cancer cells.Aug 31, 2022

Pubmed Data : Mol Biol Rep. 2022 Sep ;49(9):8741-8752. Epub 2022 Aug 21. PMID: 35988102
Article Published Date : Aug 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Crocin, Curcumin
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-Apoptotic, Antiproliferative , Chemopreventive
Additional Keywords : Natural Substance Synergy
[+]

The association of cigarette smoke exposure with lung cellular toxicity and oxidative stress: the protective role of crocin.Oct 27, 2019

Pubmed Data : Inflammation. 2019 Oct 28. Epub 2019 Oct 28. PMID: 31659585
Article Published Date : Oct 27, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Oxidative Stress, Smoking
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

The components of crocus sativus have potential anti-bacterial and anti-parasitic effects.Mar 12, 2015

Pubmed Data : J Enzyme Inhib Med Chem. 2015 Mar 13:1-7. Epub 2015 Mar 13. PMID: 25766747
Article Published Date : Mar 12, 2015
Study Type : In Vitro Study
Additional Links
Substances : Crocin, Saffron, Safranal
Diseases : Helicobacter Pylori Infection, Leishmaniasis, Plasmodium Infections
Pharmacological Actions : Anti-Bacterial Agents, Antiparasitic Agents
[+]

The effects of crocin on bone and cartilage diseases.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:830331. Epub 2022 Jan 19. PMID: 35126154
Article Published Date : Dec 31, 2020
Study Type : Review
Additional Links
Substances : Crocin
Diseases : Arthritis, Bone Diseases, Osteoarthritis, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

The present study demonstrated the anti-proliferative and apoptotic activities of crocin against both sensitive and resistant cervical cancer cells.Jul 28, 2017

Pubmed Data : Biomed Pharmacother. 2017 Jul 29 ;94:307-316. Epub 2017 Jul 29. PMID: 28763753
Article Published Date : Jul 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, Tumor Suppressor Protein p53 Upregulation
[+]

Therapeutic implications of crocin in Parkinson's disease: A review of preclinical research.Feb 07, 2023

Pubmed Data : Chem Biol Drug Des. 2023 Feb 8. Epub 2023 Feb 8. PMID: 36752710
Article Published Date : Feb 07, 2023
Study Type : Review
Additional Links
Substances : Crocin
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Therapeutic potentials of crocin in medication of neurological disorders.Sep 08, 2020

Pubmed Data : Food Chem Toxicol. 2020 Sep 9 ;145:111739. Epub 2020 Sep 9. PMID: 32916219
Article Published Date : Sep 08, 2020
Study Type : Review
Additional Links
Substances : Crocin
Diseases : Alzheimer's Disease, Epilepsy, Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

This review provides a brief insight into the anticancer properties of saffron and its components. Mar 31, 2015

Pubmed Data : J Tradit Complement Med. 2015 Apr ;5(2):81-7. Epub 2015 Jan 28. PMID: 26151016
Article Published Date : Mar 31, 2015
Study Type : Review
Additional Links
Substances : Crocetin, Crocin, Saffron, Safranal
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive
[+]

This review summarizes the protective role of saffron and its pharmacologically active constituents in the pathogenesis of inflammatory diseases.Jan 22, 2019

Pubmed Data : J Cell Physiol. 2019 Jan 23. Epub 2019 Jan 23. PMID: 30673132
Article Published Date : Jan 22, 2019
Study Type : Review
Additional Links
Substances : Crocin, Saffron
Diseases : Asthma, Atherosclerosis, Dermatitis, Inflammation, Neurodegenerative Diseases
Pharmacological Actions : Anti-Inflammatory Agents
[+]

This study implicates Crocin as a potential therapeutic strategy for coronary atherosclerosis.Jan 31, 2018

Pubmed Data : Int Immunopharmacol. 2018 Feb ;55:120-127. Epub 2017 Dec 22. PMID: 29248792
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Atherosclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor
[+]

This study implies that carotenoids may be utilised as chemosensitisers.Aug 14, 2012

Pubmed Data : Phytomedicine. 2012 Aug 15 ;19(11):977-87. Epub 2012 Jul 4. PMID: 22770743
Article Published Date : Aug 14, 2012
Study Type : In Vitro Study
Additional Links
Substances : beta-Carotene, Canthaxanthin, Crocin, Fucoxanthin
Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemothapeutic Synergy: Vinblastine
[+]

Untapping the protective role of carotenoids against respiratory diseases. Aug 31, 2022

Pubmed Data : Phytomedicine. 2022 Sep ;104:154286. Epub 2022 Jun 25. PMID: 35820304
Article Published Date : Aug 31, 2022
Study Type : Review
Additional Links
Substances : Astaxanthin, beta-Carotene, Bixin, Carotenoids, Crocin, Lycopene
Diseases : Respiratory Diseases
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

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