Crocin

Name	AC	CK
Diabetes Mellitus: Type 2	15	81
Oxidative Stress	28	51
Depression	16	46
Anxiety	8	32
Diabetic Nephropathy	11	30
Inflammation	14	30
Insulin Resistance	5	26
Hyperglycemia	3	24
Multiple Sclerosis	4	23
Alzheimer's Disease	13	21
Brain Inflammation	6	20
Hyperlipidemia	1	20
Hypoglycemia	1	20
Parkinson's Disease	11	19
Atherosclerosis	5	16
Breast Cancer	13	16
Cognitive Decline/Dysfunction	3	14
Nephropathy	3	14
Obsessive-Compulsive Disorder	3	14
Chronic Obstructive Pulmonary Disease	3	13
Gastric Cancer	6	13
Osteoarthritis	3	13
Chemotherapy-Induced Toxicity: Doxorubicin	6	12
Metabolic Syndrome X	2	12
Pesticide Toxicity	6	11
Asthma	6	10
Burning Mouth Syndrome	1	10
C-Reactive Protein	1	10
Chemotherapy-Induced Toxicity: Peripheral Neuropathy	1	10
Chronic Obstructive Lung Disease	1	10
Diabetes: Oxidative Stress	5	10
Liver Damage	5	10
Memory Disorders	5	10
Obesity	5	10
Polycystic Ovary Syndrome	1	10
Testicular Injury: Chemical/Metal Induced	5	10
Chemically-Induced Liver Damage	4	8
Kidney Damage	4	8
Lipopolysaccharide-Induced Toxicity	5	8
Liver Cancer	4	8
Liver Damage: Drug-Induced	4	8
Neurodegenerative Diseases	6	8
Rheumatoid Arthritis	5	8
Breast Cancer: Triple Negative	5	7
Cerebral Ischemia	5	7
Bisphenol Toxicity	3	6
Brain: Oxidative Stress	3	6
Chemotherapy-Induced Kidney Damage	3	6
Chemotherapy-Induced Toxicity: Cyclophosphamide	3	6
Diabetic Complications	3	6
Liver Fibrosis	3	6
Myocardial Infarction	3	6
Neuropathic Pain	3	6
Periodontitis	4	6
Sleep Disorders	3	6
Cervical Cancer	3	5
Chemotherapy-Induced Toxicity: Cisplatin	3	5
Colorectal Cancer	4	5
Diabetes Mellitus: Type 1	3	5
Head and Neck Cancer	1	5
Hypertension	3	5
Radiation	3	5
Thrombosis	1	5
Chemotherapy-Induced Toxicity: Gentamicin	2	4
Colitis	2	4
DNA damage	2	4
Drug Toxicity: Methotrexate	2	4
Hemorrhagic Shock	2	4
High Fat Diet	2	4
Hyperalgesia	2	4
Hypertension: Pulmonary	2	4
Insomnia	2	4
Ischemia	2	4
Nicotine/Tobacco Toxicity	2	4
Nonalcoholic fatty liver disease (NAFLD)	2	4
Pulmonary Fibrosis: Bleomycin-Induced	2	4
Ulcerative Colitis	3	4
Alcohol Toxicity	2	3
Arthritis	2	3
Cancers: All	3	3
Epilepsy	2	3
Lipid Peroxidation	2	3
Macular Degeneration	2	3
Pancreatic Cancer	2	3
Skin Cancer	2	3
Squamous cell carcinoma	3	3
Acrylamide-induced toxicity	1	2
Aging	1	2
Aging: Liver	1	2
Alcohol Withdrawal	1	2
Alcoholic Liver Disease	1	2
Allergic Airway Diseases	1	2
Altitude Sickness	1	2
Aluminum Toxicity	2	2
Anorexia: Stress-Induced	1	2
Atopic Dermatitis	1	2
Autism Spectrum Disorders	1	2
Benzo[a]pyrene-induced Toxicity	1	2
Brain Injury: Traumatic	1	2
Breast Cancer: Chemically-Induced	1	2
Cancer Metastasis	1	2
Cancers: Drug Resistant	2	2
Cardiomyopathy	1	2
Cardiovascular Diseases	1	2
Colon Cancer	2	2
Coronary Artery Disease	1	2
Delayed Sleep Phase Disorder	1	2
Diabetes: Memory Problems	1	2
Diabetic Retinopathy	2	2
Drug Toxicity: Isoprenaline	1	2
Echinococcosis	1	2
Endothelial Dysfunction	1	2
Fetal Alcoholism	1	2
Gestational Hypertensive	1	2
Glaucoma	2	2
Hepatic Steatosis	1	2
Human Papillomavirus (HPV)	1	2
Hydrogen Peroxide Induced Toxicity	1	2
Hypoxia	1	2
Infertility: Male	1	2
Kidney Damage: Chemically-Induced	1	2
Kidney Damage: Drug-Induced	1	2
Kidney Diseases	1	2
Learning disorders	1	2
Leishmaniasis	2	2
Liver Injury: Ischemia/reperfusion	1	2
Low Back Pain	1	2
Melanoma	1	2
Memory Disorders: Sleep Deprivation Induced	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Mycotoxin Toxicity	1	2
Myocardial Fibrosis	1	2
Myocardial Ischemia	1	2
Nasal Polyps	1	2
Oral Cancer	2	2
Osteoporosis	1	2
Ovarian Cancer	2	2
Pancreatitis	1	2
Peritonitis	1	2
Pesticide-Induced Toxicity: Organophosphates	1	2
Respiratory Distress Syndrome	1	2
Schizophrenia	1	2
Sepsis	1	2
Sperm Quality: Low	1	2
Thyroid Cancer	2	2
Traumatic Brain Injury	1	2
Acute lymphoblastic leukemia (ALL)	1	1
Advanced Glycation End products (AGE)	1	1
Aspergillosis	1	1
Autoimmune Diseases	1	1
Bone Diseases	1	1
Cancers: Multi-Drug Resistant	1	1
Candida Albicans	1	1
Cardiotoxicity: Chemotherapy-Induced	1	1
Chronic Pain	1	1
Coronavirus Infection	1	1
Dementia	1	1
Dermatitis	1	1
Dyslipidemias	1	1
Endothelial Damage	1	1
Eye Diseases	1	1
Fibrosis	1	1
Glioma	1	1
HIV Infections	1	1
Helicobacter Pylori Infection	1	1
Herpes Simplex Virus Type 1	1	1
Leukemia: Chronic myelogenous leukemia (CML)	1	1
Lung Cancer	1	1
Lung Damage	1	1
Lymphoma	1	1
Mitochondrial Dysfunction	1	1
Paraquat Toxicity	1	1
Plasmodium Infections	1	1
Prostate Cancer	1	1
Respiratory Diseases	1	1
Retinoblastoma	1	1
Smoking	1	1
Stroke	1	1
Stroke: Ischemic	1	1
Surgery: Anesthesiology	1	1

Name	AC	CK
Antioxidants	108	218
Anti-Inflammatory Agents	90	213
Neuroprotective Agents	55	111
Hypoglycemic Agents	12	95
Tumor Necrosis Factor (TNF) Alpha Inhibitor	26	79
Renoprotective	20	48
Hypolipidemic	6	46
Antidepressive Agents	15	44
Antiproliferative	28	41
Interleukin-6 Downregulation	14	41
Anti-Apoptotic	22	39
Anti-Anxiety Agents	7	38
Hepatoprotective	19	38
NF-kappaB Inhibitor	18	37
Chemoprotective Agents	13	34
Antihypertensive Agents	3	33
Cardioprotective	18	33
Anticholesteremic Agents	2	31
Apoptotic	24	29
Nrf2 activation	15	28
Interleukin-1 beta downregulation	14	25
MicroRNA modulator	9	25
Transforming growth factor beta (TGF-β) inhibitor	6	20
Heme oxygenase-1 up-regulation	11	18
Superoxide Dismutase Up-regulation	9	16
Anti-metastatic	10	14
Anti-Fibrotic	7	13
Chemopreventive	9	12
Insulin Sensitizers	2	12
Catalase Up-Regulation	6	11
Malondialdehyde Down-regulation	6	11
Chemosensitizer	7	10
Interleukin-17 downregulation	1	10
Radioprotective	5	9
Analgesics	4	8
Bcl-2 protein down-regulation	6	8
Cytoprotective	4	8
Pancreato Protective Agents	4	8
Wnt/β-catenin signaling pathway modulation	5	8
Angiogenesis Inducing Agents	2	7
Brain-derived neurotrophic factor modulator	4	7
Chemotherapeutic	6	7
Cyclooxygenase 2 Inhibitors	4	6
Radiosensitizer	2	6
Angiogenesis Inhibitors	3	4
Anticarcinogenic Agents	3	4
Cell cycle arrest	4	4
Immunomodulatory	3	4
Interleukin-4 downregulation	2	4
Matrix metalloproteinase-2 (MMP-2) inhibitor	3	4
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	4
SIRT1 Activator	2	4
Vascular Endothelial Growth Factor Inhibitors	3	4
interleukin-13 down-regulation	2	4
Antiparasitic Agents	2	3
Autophagy Inhibitors	2	3
Neurogenesis	2	3
Anti-Asthmatic Agents	1	2
Autophagy Up-regulation	1	2
Fertility Agents: Male	1	2
Gastrointestinal Agents	1	2
Gastroprotective	1	2
Glutathione Peroxidase 1 (GPx1) Up-Regulation	1	2
Glutathione Upregulation	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	2
Interferon Gamma Reducer	1	2
Interleukin-10 downregulation	1	2
Interleukin-18 down-regulation	1	2
Interleukin-5 downregulation	1	2
Matrix Metalloproteinase-7 (MMP-7) Inhibitor	1	2
Multidrug Resistance Gene Modulators	2	2
Osteoprotective	1	2
Postaglandin PGE2 downregulation	2	2
Prophylactic Agents	1	2
Telomerase Inhibitor	2	2
Tumor Suppressor Protein p53 Upregulation	2	2
Vascular Endothelial Growth Factor A Enhancer	1	2
Angiotensin-Converting Enzyme Inhibitors	1	1
Anti-Bacterial Agents	1	1
Anti-Glycation Agents	1	1
Antifungal Agents	1	1
Antineoplastic Agents	1	1
Antinoceceptive	1	1
Antiviral Agents	1	1
Caspase-3 Activation	1	1
Cyclin D1 Down-Regulation	1	1
Interleukin-12 downregulation	1	1
Leishmanicidal	1	1
STAT3 Inhibitor	1	1
Vasodilator Agents	1	1

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Pubmed Data : BMC Complement Med Ther. 2022 Oct 8 ;22(1):262. Epub 2022 Oct 8. PMID: 36209091

Article Published Date : Oct 07, 2022

Study Type : Human Study

Additional Links

Substances : Carotenoids, Crocin

Diseases : Diabetes Mellitus: Type 2, Diabetic Nephropathy

Pharmacological Actions : Antioxidants, Transforming growth factor beta (TGF-β) inhibitor

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Inflammatory markers response to crocin supplementation in patients with type 2 diabetes mellitus.Apr 14, 2021

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Pubmed Data : Phytother Res. 2021 Apr 15. Epub 2021 Apr 15. PMID: 33856733

Article Published Date : Apr 14, 2021

Study Type : Human Study

Additional Links

Substances : Crocin

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Significant effect of crocin on the gene expression of MicroRNA-21 and MicroRNA-155 in patients with osteoarthritis.Jun 17, 2022

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Pubmed Data : Int J Clin Exp Pathol. 2020 ;13(5):912-922. Epub 2020 May 1. PMID: 32509062

Article Published Date : Dec 31, 2019

Study Type : Human In Vitro

Additional Links

Substances : Crocin

Diseases : Gastric Cancer

Pharmacological Actions : Antioxidants, Antiproliferative , Nrf2 activation

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Pubmed Data : Avicenna J Phytomed. 2023 ;13(2):200-212. PMID: 37333475

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Kidney Damage, Liver Damage, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective

Anti Therapeutic Actions : Electromagnetic Field Harms

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Ameliorative effects of crocin on paraquat-induced oxidative stress in testis.Nov 30, 2019

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Pubmed Data : Life Sci. 2020 Feb 15 ;243:117245. Epub 2020 Jan 8. PMID: 31926253

Article Published Date : Feb 14, 2020

Study Type : Animal Study

Additional Links

Substances : Crocetin, Crocin, Saffron

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Anti-metastatic, Antiproliferative

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Pubmed Data : Tissue Cell. 2023 Oct ;84:102182. Epub 2023 Jul 26. PMID: 37523948

Article Published Date : Sep 30, 2023

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

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Cognitive protective mechanism of crocin pretreatment in rat submitted to acute high-altitude hypoxia exposure.Dec 31, 2019

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Pubmed Data : Nutrients. 2018 Nov 2 ;10(11). Epub 2018 Nov 2. PMID: 30400140

Article Published Date : Nov 01, 2018

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Atopic Dermatitis

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

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Pubmed Data : Adv Exp Med Biol. 2021 ;1328:275-285. PMID: 34981484

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Carotenoids, Crocin

Diseases : Diabetes: Oxidative Stress

Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation

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Crocin improves insulin sensitivity and ameliorates adiposity.Dec 31, 2019

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Pubmed Data : Biomed Res Int. 2020 ;2020:9136282. Epub 2020 Jun 6. PMID: 32596392

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Insulin Resistance, Obesity

Pharmacological Actions : Insulin Sensitizers

Additional Keywords : Anti-Obesity Agents

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Crocin improves nicotine-induced adverse effects on reproductive parameters in male mice.Mar 31, 2016

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Pubmed Data : Asian Pac J Cancer Prev. 2016 ;17(3):1499-506. PMID: 27039797

Article Published Date : Dec 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Crocin

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic

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Crocin induces autophagic cell death and inhibits cell invasion of cervical cancer SiHa cells through activation of PI3K/AKT.Aug 31, 2020

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Crocin may be a promising therapeutic agent for preventing and improving diabetes-related kidney disease.Jan 31, 2023

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Pubmed Data : J Exp Pharmacol. 2020 ;12:97-106. Epub 2020 Apr 28. PMID: 32431552

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Neuropathic Pain

Pharmacological Actions : Analgesics

Additional Keywords : Endocannabinoid System

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Crocin's role in modulating MMP2/TIMP1 and mitigating hypoxia-induced pulmonary hypertension in mice.Jun 02, 2024

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Pubmed Data : J Pharm Pharm Sci. 2005;8(3):387-93. Epub 2005 Aug 22. PMID: 16401388

Article Published Date : Jan 01, 2005

Study Type : Animal Study

Additional Links

Substances : Carotenoids, Crocin, Saffron

Diseases : Kidney Diseases

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Crocin-I protects against high-fat diet-induced obesity.Dec 31, 2021

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Pubmed Data : Front Pharmacol. 2022 ;13:894089. Epub 2022 Aug 11. PMID: 36034852

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Pubmed Data : Brain Res. 2021 Mar 1 ;1754:147274. Epub 2021 Jan 7. PMID: 33422526

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Pubmed Data : Onco Targets Ther. 2021 ;14:111-122. Epub 2021 Jan 7. PMID: 33442270

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Nutritional support of crocin on neurobehavioral disabilities induced by cisplatin.Feb 29, 2024

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Pubmed Data : Neurochem Res. 2024 Mar ;49(3):649-659. Epub 2023 Nov 27. PMID: 38010604

Article Published Date : Feb 29, 2024

Study Type : Animal Study

Additional Links

Substances : Carotenoids, Crocin

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Oxidative Stress

Pharmacological Actions : Antioxidants, Chemoprotective Agents, Neuroprotective Agents, Superoxide Dismutase Up-regulation

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Pubmed Data : Metab Brain Dis. 2023 Feb 20. Epub 2023 Feb 20. PMID: 36807082

Article Published Date : Feb 19, 2023

Study Type : Animal Study

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Substances : Crocin

Diseases : Memory Disorders

Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Neuroprotective Agents

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The effect of triptolide combined with crocin on arthritis.Dec 31, 2021

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Pubmed Data : Front Pharmacol. 2022 ;13:908227. Epub 2022 Jun 23. PMID: 35814255

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Crocin, Triptolide

Diseases : Arthritis

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Gene Expression Regulation

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The protection of crocin against ulcerative colitis and colorectal cancer. Dec 31, 2020

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Pubmed Data : Front Pharmacol. 2021 ;12:639458. Epub 2021 Mar 18. PMID: 33841156

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Colitis, Colorectal Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, NF-kappaB Inhibitor

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These results demonstrated that the suppression of crocin on airway inflammation and hyper-reactivity in a murine model.May 31, 2015

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Pubmed Data : Immunopharmacol Immunotoxicol. 2015 Jun ;37(3):236-43. Epub 2015 Mar 10. PMID: 25753844

Article Published Date : May 31, 2015

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Asthma, Inflammation

Pharmacological Actions : Anti-Asthmatic Agents, Anti-Inflammatory Agents, interleukin-13 down-regulation, Interleukin-4 downregulation, Interleukin-5 downregulation

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Additional Keywords : Cardioprotective, Cardiovascular Diseases, Crocin, exercise, MicroRNA modulator

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Crocin: A fighter against inflammation and pain.Jul 04, 2020

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Pubmed Data : Food Chem Toxicol. 2020 Jul 5 ;143:111521. Epub 2020 Jul 5. PMID: 32640351

Article Published Date : Jul 04, 2020

Study Type : Review

Additional Links

Substances : Crocin

Diseases : Chronic Pain, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive , NF-kappaB Inhibitor

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Pubmed Data : J Thorac Dis. 2019 Nov ;11(11):4464-4473. PMID: 31903234

Article Published Date : Oct 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Crocin

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Angiogenesis Inhibitors, Apoptotic, Cell cycle arrest

Additional Keywords : Dose Response

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Beneficial effects of crocin against depression.Dec 31, 2019

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Crocin and picrocrocin could be a promising anti-HSV and anti-HIV agent for herbal therapy against viral infections.Dec 31, 2017

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Pubmed Data : Curr Drug Deliv. 2018 ;15(5):698-704. PMID: 29189153

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Pubmed Data : West Indian Med J. 2016 Apr 18. Epub 2016 Apr 18. PMID: 27398676

Article Published Date : Apr 17, 2016

Study Type : In Vitro Study

Additional Links

Substances : Crocin

Diseases : Acute lymphoblastic leukemia (ALL)

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Dose Response

[+]

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Pubmed Data : Asian Pac J Cancer Prev. 2020 07 1 ;21(7):1959-1967. Epub 2020 Jul 1. PMID: 32711421

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Pubmed Data : Sci Rep. 2017 Mar 24 ;7:44984. Epub 2017 Mar 24. PMID: 28337976

Article Published Date : Mar 23, 2017

Study Type : In Vitro Study

Additional Links

Substances : Crocin

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative

[+]

Crocin inhibits angiogenesis and metastasis in colon cancer. Jan 28, 2022

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Pubmed Data : Transl Lung Cancer Res. 2015 Dec ;4(6):775-83. PMID: 26798587

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Pubmed Data : Indian J Clin Biochem. 2024 Apr ;39(2):283-290. Epub 2022 Nov 17. PMID: 38577135

Article Published Date : Mar 31, 2024

Study Type : In Vitro Study

Additional Links

Substances : Crocin

Diseases : Paraquat Toxicity

Pharmacological Actions : Antioxidants

Problem Substances : Paraquat

[+]

Nanoencapsulation of crocin in double-layer emulsions for improved stability and enhanced efficacy against depression.Dec 31, 2022

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Pubmed Data : Anticancer Drugs. 2023 Feb 24. Epub 2023 Feb 24. PMID: 36847076

Article Published Date : Feb 23, 2023

Study Type : In Vitro Study

Additional Links

Substances : Crocin, Water: Deuterium Depleted

Pharmacological Actions : Antiproliferative , Cell cycle arrest

Additional Keywords : Natural Substance Synergy

[+]

Synergistic anticancer effects of curcumin and crocin on human colorectal cancer cells.Aug 31, 2022

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Pubmed Data : Mol Biol Rep. 2022 Sep ;49(9):8741-8752. Epub 2022 Aug 21. PMID: 35988102

Article Published Date : Aug 31, 2022

Study Type : In Vitro Study

Additional Links

Substances : Crocin, Curcumin

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-Apoptotic, Antiproliferative , Chemopreventive

Additional Keywords : Natural Substance Synergy

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Effect of Crocus sativus and crocin in the treatment of patients with type-2 diabetes mellitus.Sep 28, 2023

Saffron and crocin may modulate the serum lipid profile in patient with metabolic disorders.Feb 03, 2020

The effect of crocin supplementation on lipid concentrations and fasting blood glucose.Jul 31, 2020

Crocin considerably seems to be effective for relieving symptoms of CIPN in cancer patients receiving chemotherapy agents.Aug 10, 2021

The findings indicate that crocin supplementation can improve glycemic control and insulin resistance in patients with T2D.Dec 31, 2019

A pilot study of the effects of crocin on high-density lipoprotein cholesterol uptake capacity in patients with metabolic syndrome.Oct 04, 2021

Crocin alleviates cognitive impairment associated with atherosclerosis.Jan 26, 2022

Crocin can be considered for treatment of burning mouth syndrome.Oct 31, 2019

Crocin can be effective in controlling the level of FBS and HbA1c in patients with type 2 diabetes.Dec 31, 2021

Crocin is effective in treatment of patients with mild to moderate OCD with possibly fewer adverse effects compared to fluoxetine.Feb 17, 2021

Crocin supplementation appears to effectively establish oxidant/antioxidant balance and improve inflammatory conditions in patients with COPD.Dec 31, 2021

Effect of crocin of Crocus sativus on serum inflammatory markers in chronic obstructive pulmonary disease patients.Jan 10, 2023

Effects of crocin on inflammatory biomarkers and mental health status in patients with multiple sclerosis.Feb 29, 2024

Effects of crocin supplementation on inflammatory markers, lipid profiles, insulin and cardioprotective indices in women with PCOS.May 31, 2022

Evaluation of crocin effect on contrast-induced nephropathy following coronary angiography or angioplasty.Nov 30, 2022

Evaluation of therapeutic effects of crocin in attenuating the progression of diabetic nephropathy.Oct 07, 2022

Inflammatory markers response to crocin supplementation in patients with type 2 diabetes mellitus.Apr 14, 2021

Significant effect of crocin on the gene expression of MicroRNA-21 and MicroRNA-155 in patients with osteoarthritis.Jun 17, 2022

These results demonstrated the effect of crocin in depression and could be administered in treatment of MDD patients.Mar 14, 2015

These results suggest the beneficial and therapeutic effects of crocin in multiple sclerosis.Oct 15, 2019

Crocin can be considered as a potential drug and sensitizer in cancer treatment. Dec 31, 2016

Crocin improves lower extremity deep venous thrombosis.Sep 29, 2023

Pathogenesis and anti-proliferation mechanisms of crocin in human gastric carcinoma cells.Dec 31, 2019

Crocin combined With cisplatin regulates proliferation, apoptosis and Emt of gastric cancer cells.Sep 14, 2023

Protective effect of crocin on peroxidation-induced oxidative stress and apoptosis in IPEC-J2 cells.Mar 11, 2024

Therapeutic effects of crocin alone or in combination with sorafenib against hepatocellular carcinoma.Aug 24, 2022

Crocin ameliorates oxidative stress and suppresses renal damage in streptozotocin induced diabetic male rats.Aug 23, 2020

A natural carotenoid crocin exerts antidepressant action.Dec 31, 2022

Administering crocin ameliorates anxiety-like behaviors and reduces the inflammatory response in amyloid-beta induced neurotoxicity.Mar 07, 2021

Administration of crocin reduced d-galactose-induced aging.Dec 31, 2017

Ameliorative effect of crocin on sperm parameters and in vitro fertilization in mice under oxidative stress induced by paraquat.Dec 31, 2019

Ameliorative effects of crocin against electromagnetic field-induced oxidative stress and liver and kidney injuries in mice.Dec 31, 2022

Ameliorative effects of crocin on paraquat-induced oxidative stress in testis.Nov 30, 2019

Ameliorative effects of crocin on tartrazine dye-induced pancreatic adverse effects.Aug 31, 2020

Anti-epileptic effect of crocin on experimental temporal lobe epilepsy.Dec 31, 2021

Anti-metastatic properties of a potent herbal combination in cell and mice models of triple negative breast cancer.Feb 14, 2020

Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone.Oct 11, 2019

Antidepressant effect of crocin in mice with chronic mild stress. Aug 24, 2022

Antidiabetic and antioxidant potential of Crocin in high-fat diet plus streptozotocin-induced type-2 diabetic rats.Dec 31, 2023

Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice.Apr 30, 2018

Antioxidant and anti-inflammatory effects of crocin ameliorate doxorubicin-induced nephrotoxicity.Dec 31, 2020

Antioxidant and anti-inflammatory potential of crocin on the doxorubicin mediated hepatotoxicity.Sep 30, 2023

Cognitive protective mechanism of crocin pretreatment in rat submitted to acute high-altitude hypoxia exposure.Dec 31, 2019

Crocetin and crocin are potential natural biomedicines for the management of diseases associated with abnormal blood vessel growth.Dec 31, 2020

Crocin administration could protect the liver damage induced by morphine.Feb 29, 2016

Crocin administration may reduce inflammation-driven tissue damage in patients with hemorrhagic shock.Apr 27, 2017

Crocin alleviates lipopolysaccharide-induced acute respiratory distress syndrome.Jan 09, 2020

Crocin alleviates the inflammation and oxidative stress responses associated with diabetic nephropathy.Apr 25, 2021

Crocin ameliorates atherosclerosis.Dec 31, 2021

Crocin ameliorates atopic dermatitis symptoms by down regulation of the Th2 cells-mediated immune response.Nov 01, 2018

Crocin ameliorates chronic obstructive pulmonary disease-induced depression.Sep 02, 2019

Crocin ameliorates depressive-like behaviors induced by chronic restraint stress.Dec 31, 2021

Crocin ameliorates diabetic nephropathy.Dec 31, 2022

Crocin ameliorates hepatic steatosis through activation of AMPK signalling.Jan 07, 2019

Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation.Jul 31, 2019

Crocin ameliorates MicroRNAs-associated ER stress in type 2 diabetes induced by methylglyoxal.Jan 31, 2022

Crocin ameliorates neuroinflammation and cognitive impairment.Apr 30, 2024

Crocin and crocetin showed a significant protective effect against the N-methyl-N-nitrosourea induced breast cancer in rats.Mar 31, 2017

Crocin and crocetin significantly increased the total time of non-rapid eye movement (non-REM) sleep after the administration.Jan 31, 2012

Crocin and curcumin, either alone or in combination, can be a suitable treatment modality for rheumatoid arthritis.Apr 07, 2023

Crocin and Metformin suppress metastatic breast cancer progression.Apr 29, 2021

Crocin and voluntary exercise promote heart angiogenesis through Akt and ERK1/2 signalling in type 2 diabetic rats.Dec 31, 2017

Crocin as a novel therapeutic agent against colitis.Feb 02, 2019

Crocin as a potential candidate to prevent anxiety and depressive-like behaviors.Nov 19, 2022

Crocin at a dose of 60 mg/kg for six weeks could be effective in preventing nitrosative stress in hemiparkinsonian rats.Oct 31, 2016

Crocin attenuates CCl 4-induced liver fibrosis via PPAR-γ mediated modulation of inflammation and fibrogenesis in rats.Nov 30, 2020

Crocin attenuates cyclophosphamide induced testicular toxicity by preserving glutathione redox system.Apr 30, 2018

Crocin attenuates inflammation of lung tissue in ovalbumin-sensitized mice.Nov 30, 2021

Crocin attenuates isoprenaline-induced myocardial fibrosis.Aug 06, 2019

Crocin attenuates lung inflammation and pulmonary vascular dysfunction in a rat model of bleomycin-induced pulmonary fibrosis.Aug 25, 2019

Crocin attenuates metabolic syndrome-induced osteoporosis.Jun 30, 2019

Crocin attenuates osteoarthritis symptoms through alleviating oxidative stress and inflammation.Aug 06, 2017

Crocin

View the Evidence:
311 Abstracts with Crocin Research