Cucurbitacin D

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1 Diseases Researched for Cucurbitacin D

Name	AC	CK	Focus
Cervical Cancer	1	3

4 Pharmacological Actions Researched for Cucurbitacin D

Name	AC	CK
Antiproliferative	1	3
Apoptotic	1	3
Cell cycle arrest	1	3
MicroRNA modulator	1	3

Research Articles 1
Cumulative Knowledge Score 1
Overall Research Rating GOOD

View the Evidence:
14 Abstracts with Cucurbitacin D Research

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These results demonstrate the potential therapeutic efficacy of Cucurbitacin D against cervical cancer.Nov 07, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2016 Nov 8 ;6:36594. Epub 2016 Nov 8. PMID: 27824155

Article Published Date : Nov 07, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cucurbitacin D

Diseases : Cervical Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, MicroRNA modulator

[+]

Anti-HIV activity of cucurbitacin-D against cigarette smoke condensate-induced HIV replication.May 26, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Viruses. 2021 May 27 ;13(6). Epub 2021 May 27. PMID: 34072078

Article Published Date : May 26, 2021

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin D

Diseases : HIV Drug-Induced Toxicity , HIV Infections

Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents, Interleukin-1 beta downregulation

[+]

Autophagy is associated with cucurbitacin D-induced apoptosis in human T cell leukemia cells.Mar 31, 2016

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Pubmed Data : Med Oncol. 2016 Apr ;33(4):30. Epub 2016 Feb 25. PMID: 26913856

Article Published Date : Mar 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin D

Diseases : Acute T cell Leukemias

Pharmacological Actions : Apoptotic

[+]

Cucurbitacin D decreases cell proliferation and induces apoptosis in doxorubicin-resistant breast cancer cells.Oct 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Cell Biochem. 2015 Nov ;409(1-2):33-43. Epub 2015 Jul 14. PMID: 26169986

Article Published Date : Oct 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin D

Diseases : Breast Cancer, Cancers: Drug Resistant

Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic, NF-kappaB Inhibitor

Additional Keywords : Drug: Doxorubicin

[+]

Cucurbitacin D impedes gastric cancer cell survival.Apr 09, 2018

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Pubmed Data : Oncol Rep. 2018 Apr 10. Epub 2018 Apr 10. PMID: 29658590

Article Published Date : Apr 09, 2018

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin D

Diseases : Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Cucurbitacin D inhibits the proliferation of HepG2 cells and induces apoptosis.Jun 22, 2022

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Pubmed Data : Curr Cancer Drug Targets. 2022 Jun 23. Epub 2022 Jun 23. PMID: 35786188

Article Published Date : Jun 22, 2022

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin D

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Cucurbitacin D is a promising candidate that should be explored further for its effectiveness as an anticancer agent against pancreatic cancer.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:6571674. Epub 2020 Sep 22. PMID: 33029168

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin D

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

[+]

Cucurbitacin D isolated from Trichosanthes kirilowii could be a valuable candidate for anti-tumor treatment.Mar 31, 2009

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Pubmed Data : Int Immunopharmacol. 2009 Apr ;9(4):508-13. Epub 2009 Jan 29. PMID: 19185617

Article Published Date : Mar 31, 2009

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin D, Trichosanthes Kirilowii

Diseases : Liver Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

[+]

Cucurbitacin D might be a new therapeutic option for the treatment of endometrial and ovarian cancers.Jan 31, 2013

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Pubmed Data : Tumour Biol. 2013 Feb ;34(1):285-91. Epub 2012 Nov 14. PMID: 23150173

Article Published Date : Jan 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin D

Diseases : Endometrial Cancer, Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

[+]

Cucurbitacin D overcomes gefitinib resistance in gefitinib-resistant NSCLC cells.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Oncol. 2020 ;10:62. Epub 2020 Feb 18. PMID: 32133284

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin D

Diseases : Cancers: Drug Resistant, Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Apoptotic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Gefitinib

[+]

Cucurbitacin D reprograms glucose metabolic network in prostate cancer.Mar 13, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancers (Basel). 2019 Mar 14 ;11(3). Epub 2019 Mar 14. PMID: 30875788

Article Published Date : Mar 13, 2019

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin D

Diseases : Prostate Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative

[+]

Cucurbitacin-D-induced inhibition of proliferation in non-small cell lung carcinoma cell line (NSCLC-N6).Aug 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Anticancer Res. 2014 Sep ;34(9):4797-806. PMID: 25202060

Article Published Date : Aug 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin D

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Antiproliferative

[+]

Novel mechanistic insight into the anticancer activity of cucurbitacin D against pancreatic cancer.Dec 30, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cells. 2019 Dec 31 ;9(1). Epub 2019 Dec 31. PMID: 31906106

Article Published Date : Dec 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin D

Diseases : Cancers: Drug Resistant, Pancreatic Cancer

Pharmacological Actions : Antiproliferative

[+]

The cucurbitacins D, E, and I upregulate the LC3 gene and induce cell-cycle arrest in human gastric cancer cell line AGS.Feb 28, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2018 Mar ;21(3):253-259. PMID: 29511491

Article Published Date : Feb 28, 2018

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin D, Cucurbitacin E

Diseases : Gastric Cancer

Pharmacological Actions : Antiproliferative , Cell cycle arrest

Additional Keywords : Gene Expression Regulation

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Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 14 Abstracts with Cucurbitacin D Research

Limited to Members Only

Currently Available Sorting Options

These results demonstrate the potential therapeutic efficacy of Cucurbitacin D against cervical cancer.Nov 07, 2016

Anti-HIV activity of cucurbitacin-D against cigarette smoke condensate-induced HIV replication.May 26, 2021

Autophagy is associated with cucurbitacin D-induced apoptosis in human T cell leukemia cells.Mar 31, 2016

Cucurbitacin D decreases cell proliferation and induces apoptosis in doxorubicin-resistant breast cancer cells.Oct 31, 2015

Cucurbitacin D impedes gastric cancer cell survival.Apr 09, 2018

Cucurbitacin D inhibits the proliferation of HepG2 cells and induces apoptosis.Jun 22, 2022

Cucurbitacin D is a promising candidate that should be explored further for its effectiveness as an anticancer agent against pancreatic cancer.Dec 31, 2019

Cucurbitacin D isolated from Trichosanthes kirilowii could be a valuable candidate for anti-tumor treatment.Mar 31, 2009

Cucurbitacin D might be a new therapeutic option for the treatment of endometrial and ovarian cancers.Jan 31, 2013

Cucurbitacin D overcomes gefitinib resistance in gefitinib-resistant NSCLC cells.Dec 31, 2019

Cucurbitacin D reprograms glucose metabolic network in prostate cancer.Mar 13, 2019

Cucurbitacin-D-induced inhibition of proliferation in non-small cell lung carcinoma cell line (NSCLC-N6).Aug 31, 2014

Novel mechanistic insight into the anticancer activity of cucurbitacin D against pancreatic cancer.Dec 30, 2019

The cucurbitacins D, E, and I upregulate the LC3 gene and induce cell-cycle arrest in human gastric cancer cell line AGS.Feb 28, 2018

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Cucurbitacin D

View the Evidence:
14 Abstracts with Cucurbitacin D Research