Curcumin: Degradiation byproducts

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8 Diseases Researched for Curcumin: Degradiation byproducts
NameACCKFocus
Breast Cancer15Locked
Inflammation33Locked
Cancers: All22Locked
Inflammatory Bowel Diseases12Locked
Depression11Locked
Fungal Infection11Locked
Lipopolysaccharide-Induced Toxicity11Locked
Malaria11Locked
16 Pharmacological Actions Researched for Curcumin: Degradiation byproducts
NameACCKFocus
Anti-Inflammatory Agents56Locked
Apoptotic26Locked
Antiproliferative 15Locked
Bcl-2 protein down-regulation15Locked
Caspase-3 Activation15Locked
Cell cycle arrest15Locked
P21 Activation15Locked
Interleukin-6 Downregulation23Locked
Antioxidants22Locked
NF-kappaB Inhibitor22Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor12Locked
Anti-Platelet11Locked
Antidepressive Agents11Locked
Antifungal Agents11Locked
Antimalarials11Locked
Chemopreventive11Locked

View the Evidence:
8 Abstracts with Curcumin: Degradiation byproducts Research

[+]

Tetrahydrocurcumin exhibited significant cell growth inhibition by inducing MCF-7 cells to undergo mitochondrial apoptosis and G2/M arrest.Apr 30, 2014

Pubmed Data : Food Chem Toxicol. 2014 May ;67:193-200. Epub 2014 Mar 1. PMID: 24593988
Article Published Date : Apr 30, 2014
Study Type : Human In Vitro
Additional Links
Substances : Curcumin: Degradiation byproducts, Tetrahydrocurcumin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Cell cycle arrest, P21 Activation
[+]

Dehydrozingerone showed an activity comparable to that of sulfasalazine and protected the mucosa from the deleterious effects of DNCB.Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Mag. 2015 Oct ;11(Suppl 2):S296-302. PMID: 26664018
Article Published Date : Sep 30, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin: Degradiation byproducts
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

A total of 23 curcumin metabolites were detected, and identified a number of novel metabolic pathways of curcumin in the human intestinal microflora system.Mar 14, 2015

Pubmed Data : J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Mar 15 ;985:38-47. Epub 2015 Jan 24. PMID: 25658514
Article Published Date : Mar 14, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Curcumin: Degradiation byproducts
Additional Keywords : Microbiota
[+]

Bioactive degradation products may contribute to the pharmacological effects of curcumin.Feb 29, 2012

Pubmed Data : Trends Mol Med. 2012 Mar ;18(3):138-44. Epub 2012 Mar 1. PMID: 22386732
Article Published Date : Feb 29, 2012
Study Type : Review
Additional Links
Substances : Curcumin: Degradiation byproducts, Turmeric: Fermented
[+]

curcumin and its major metabolites inhibited the LPS‑induced inflammatory response via the mechanism of inhibiting NF‑κB translocation to the nucleus.Mar 31, 2015

Pubmed Data : Mol Med Rep. 2015 Apr ;11(4):3087-93. Epub 2014 Dec 11. PMID: 25502175
Article Published Date : Mar 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Curcumin: Degradiation byproducts
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
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Current data suggest that curcumin undergoes degradation due to roasting and its degradation product exhibit significant biological activity in cultured cells.Mar 10, 2015

Pubmed Data : Food Funct. 2015 Mar 11 ;6(3):887-93. PMID: 25619943
Article Published Date : Mar 10, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Curcumin: Degradiation byproducts
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation
Additional Keywords : Gene Expression
[+]

Dehydrozingerone is known to have a broad range of biological activities.Jan 01, 2016

Pubmed Data : Bioorg Med Chem. 2016 Jan 2. Epub 2016 Jan 2. PMID: 26796952
Article Published Date : Jan 01, 2016
Study Type : Review
Additional Links
Substances : Curcumin: Degradiation byproducts
Diseases : Cancers: All, Depression, Fungal Infection, Inflammation, Malaria
Pharmacological Actions : Anti-Inflammatory Agents, Anti-Platelet, Antidepressive Agents, Antifungal Agents, Antimalarials, Antioxidants
[+]

This review summarizes the understanding of chemopreventive effects of curcumin in the prevention of cancer via the regulation of various cell signaling and genetic pathways.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2014 ;2014:761608. Epub 2014 Sep 10. PMID: 25295272
Article Published Date : Dec 31, 2013
Study Type : Review
Additional Links
Substances : Curcumin, Curcumin: Degradiation byproducts
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Apoptotic, Chemopreventive, NF-kappaB Inhibitor

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