Curcumol

Name	AC	CK
Breast Cancer: Triple Negative	1	3
Lung Cancer	2	3
Colorectal Cancer	1	2

Name	AC	CK
Apoptotic	4	8
Antiproliferative	2	4
Tumor Suppressor Protein p53 Upregulation	1	3
Bcl-2 protein down-regulation	1	2
Cell cycle arrest	1	2

[+]

A potential anti-liver fibrosis mechanism of curcumol may be associated with the inhibition of NLRP3 inflammasomes.Jul 27, 2021

Click here to read the entire abstract

Pubmed Data : Chin J Integr Med. 2021 Jul 28. Epub 2021 Jul 28. PMID: 34319504

Article Published Date : Jul 27, 2021

Study Type : Animal Study

Additional Links

Substances : Curcumol

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective

[+]

Curcumol ameliorates lung inflammation and airway remodeling.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2021 ;15:2641-2651. Epub 2021 Jun 21. PMID: 34188444

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Curcumol

Diseases : Asthma

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Curcumol attenuates epithelial-mesenchymal transition of nasopharyngeal carcinoma cells via TGF-β1.May 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2018 Jun ;17(6):7513-7520. Epub 2018 Mar 28. PMID: 29620189

Article Published Date : May 31, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Nasopharyngeal Cancer

Pharmacological Actions : Anti-metastatic, Apoptotic

[+]

Curcumol controls choriocarcinoma stem-like cells self-renewal.Jan 23, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Med Sci Monit. 2018 Jan 24 ;24:461-472. Epub 2018 Jan 24. PMID: 29363667

Article Published Date : Jan 23, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Choriocarcinoma

Pharmacological Actions : Histone deacetylase inhibitor

Additional Keywords : Cancer Stem Cells, Epigenetic Modification In Cancer

[+]

Curcumol could suppress the growth of human colorectal cancer xenografts in vivo.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2015 ;16(8):19851-67. Epub 2015 Aug 20. PMID: 26307972

Article Published Date : Dec 31, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation

[+]

Curcumol exhibited time and concentration dependent anti-proliferative and apoptosis-inductive activities in SPC-A-1human lung adenocarcinoma cells.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(6):2307-12. PMID: 25824755

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Curcumol

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Dose Response, Selective Cytotoxicity

[+]

Curcumol may be a potential compound for use in the development of novel triple-negative breast cancer therapeutics.Jun 30, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2017 Jul ;14(1):1080-1088. Epub 2017 May 29. PMID: 28693277

Article Published Date : Jun 30, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation

[+]

Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.Jan 26, 2020

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2020 Jan 27. Epub 2020 Jan 27. PMID: 31989700

Article Published Date : Jan 26, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Chemically-Induced Liver Damage, Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective

[+]

Curcumol might represent a promising lead compound for the development of new targeted anti-cancer therapeutics.Apr 08, 2020

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2020 Apr 9 ;257:112835. Epub 2020 Apr 9. PMID: 32278762

Article Published Date : Apr 08, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor

[+]

Curcumol promotes vascular endothelial growth factor-mediated diabetic wound healing.Jan 30, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Med Sci Monit. 2017 Jan 31 ;23:555-562. Epub 2017 Jan 31. PMID: 28138126

Article Published Date : Jan 30, 2017

Study Type : Animal Study

Additional Links

Substances : Curcumol

Diseases : Diabetic Complications, Wound Healing

Pharmacological Actions : Angiogenesis Inducing Agents, Vascular Endothelial Growth Factor Regulator

[+]

These results indicate the potential of curcumol in the prevention of colon cancer carcinogenesis.Jan 09, 2018

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2018 Jan 10 ;210:1-9. Epub 2017 Jul 4. PMID: 28684297

Article Published Date : Jan 09, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemopreventive, Cyclin D1 Down-Regulation, P21 Activation

[+]

An overview of the therapeutic effects of curcumol in several diseases.Apr 13, 2020

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2020 Apr 14:1-15. Epub 2020 Apr 14. PMID: 32285707

Article Published Date : Apr 13, 2020

Study Type : Review

Additional Links

Substances : Curcumol

Diseases : Breast Cancer, Colorectal Cancer, Head and Neck Cancer, Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Anti-proliferative benefit of curcumol on human bladder cancer cells via inactivating EZH2 effector.Jul 31, 2018

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2018 Aug ;104:798-805. Epub 2018 May 29. PMID: 29852354

Article Published Date : Jul 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Bladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Blockade of periostin-dependent migration and adhesion by curcumol via inhibition of nuclear factor kappa B signaling in hepatic stellate cells.Dec 31, 2019

Click here to read the entire abstract

Pubmed Data : Toxicology. 2020 07 ;440:152475. Epub 2020 Apr 25. PMID: 32344006

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor

[+]

Curcumol alleviates the inflammation of nucleus pulposus cells via the PI3K/Akt/NF-κB signaling pathway and delays intervertebral disk degeneration.Aug 23, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World Neurosurg. 2021 Aug 24. Epub 2021 Aug 24. PMID: 34450323

Article Published Date : Aug 23, 2021

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Degenerative Disk Disease

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Curcumol and curcumin showed an anti-inflammatory effect by inhibiting the NF-κB signaling pathway.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:3035125. Epub 2019 Mar 17. PMID: 31007701

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Curcumol

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Curcumol and FTY720 synergistically induce apoptosis and differentiation in chronic myelomonocytic leukemia via multiple signaling pathways.Mar 31, 2021

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2021 Apr ;35(4):2157-2170. Epub 2020 Dec 4. PMID: 33274566

Article Published Date : Mar 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Chronic Myeloid Leukemia

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Curcumol attenuates liver sinusoidal endothelial cell angiogenesis via regulating Glis-PROX1-HIF-1α in liver fibrosis.Feb 29, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Prolif. 2020 Mar ;53(3):e12762. Epub 2020 Mar 2. PMID: 32119185

Article Published Date : Feb 29, 2020

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Liver Cirrhosis, Liver Fibrosis

Pharmacological Actions : Anti-Angiogenic, Anti-Fibrotic

[+]

Curcumol combined with metformin may hold promise as a therapeutic strategy for triple-negative breast cancer.Jul 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Ann Transl Med. 2020 Aug ;8(15):946. PMID: 32953746

Article Published Date : Jul 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy

[+]

Curcumol demonstrated potential antitumor activities in MG-63 cells and may be used as a novel effective reagent in the treatment of osteosarcoma.Nov 30, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2017 Dec ;14(6):6387-6394. Epub 2017 Sep 21. PMID: 29151904

Article Published Date : Nov 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Osteosarcoma

Pharmacological Actions : Apoptotic, Autophagy Up-regulation

[+]

Curcumol enhances the sensitivity of doxorubicin in triple-negative breast cancer.Jan 09, 2020

Click here to read the entire abstract

Pubmed Data : Biochem Pharmacol. 2020 Jan 10 ;174:113795. Epub 2020 Jan 10. PMID: 31926937

Article Published Date : Jan 09, 2020

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Antiproliferative , MicroRNA modulator

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

[+]

Curcumol exerts anticancer effect in cholangiocarcinoma cells.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Physiol. 2018 ;9:234. Epub 2018 Mar 20. PMID: 29615928

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Cholangiocarcinoma

Pharmacological Actions : Antiproliferative , Cell cycle arrest

[+]

Curcumol improves cisplatin sensitivity of human gastric cancer cells through inhibiting PI3K/AKT pathway.Jul 25, 2020

Click here to read the entire abstract

Pubmed Data : Drug Dev Res. 2020 Jul 26. Epub 2020 Jul 26. PMID: 32715509

Article Published Date : Jul 25, 2020

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Cancers: Drug Resistant, Gastric Cancer

Pharmacological Actions : Apoptotic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

Curcumol induces cell cycle arrest and apoptosis in human nasopharyngeal carcinoma CNE-2 cells.Oct 31, 2018

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2018 Nov ;32(11):2214-2225. Epub 2018 Aug 2. PMID: 30069933

Article Published Date : Oct 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Nasopharyngeal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

[+]

Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells.Jan 09, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Redox Biol. 2018 10 ;19:375-387. Epub 2018 Sep 7. PMID: 30237126

Article Published Date : Jan 09, 2018

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Liver Cirrhosis, Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic

[+]

Curcumol inhibits EBV-positive Nasopharyngeal carcinoma migration and invasion by targeting nucleolin.Aug 20, 2021

Click here to read the entire abstract

Pubmed Data : Biochem Pharmacol. 2021 Aug 21 ;192:114742. Epub 2021 Aug 21. PMID: 34428442

Article Published Date : Aug 20, 2021

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Nasopharyngeal Cancer

Pharmacological Actions : Antiproliferative

[+]

Curcumol inhibits lung adenocarcinoma growth and metastasis.Jun 15, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Res. 2020 Jun 16. Epub 2020 Jun 16. PMID: 32886059

Article Published Date : Jun 15, 2020

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Lung Cancer

Pharmacological Actions : Anti-metastatic, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Curcumol inhibits the proliferation and metastasis of melanoma.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Cancer. 2020 ;11(7):1679-1692. Epub 2020 Jan 14. PMID: 32194780

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Cancer Metastasis, Melanoma

Pharmacological Actions : Anti-metastatic, MicroRNA modulator

[+]

Curcumol inhibits the proliferation of gastric adenocarcinoma MGC-803 cells via downregulation of IDH1.Nov 30, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Rep. 2017 Dec ;38(6):3583-3591. Epub 2017 Oct 12. PMID: 29039582

Article Published Date : Nov 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

[+]

Curcumol inhibits the viability and invasion of colorectal cancer cells via miR-30a-5p and Hippo signaling pathway.Mar 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2021 Apr ;21(4):299. Epub 2021 Feb 17. PMID: 33732375

Article Published Date : Mar 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , MicroRNA modulator

[+]

Curcumol may alleviate psoriasis-like inflammation by inhibiting keratinocyte proliferation and inflammatory gene expression.Jan 26, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Aging (Albany NY). 2021 07 27 ;13(14):18392-18403. Epub 2021 Jul 27. PMID: 34314383

Article Published Date : Jan 26, 2021

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Psoriasis

Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , STAT3 Inhibitor

[+]

Curcumol may be one of the mechanisms of antihepatic fibrosis by inhibiting the activity of the NF-κB signaling.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:8590638. Epub 2020 May 28. PMID: 32595742

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Curcumol overcomes TRAIL resistance of non-small cell lung cancer.Oct 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Adv Sci (Weinh). 2020 Nov ;7(22):2002306. Epub 2020 Oct 15. PMID: 33240775

Article Published Date : Oct 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Lung Cancer

Pharmacological Actions : Chemotherapeutic

[+]

Curcumol potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer.Dec 28, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2017 Dec 29 ;8(70):115526-115545. Epub 2017 Dec 14. PMID: 29383179

Article Published Date : Dec 28, 2017

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Apoptotic, Chemosensitizer, Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy

[+]

Curcumol suppresses breast cancer cell metastasis.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Integr Cancer Ther. 2016 06 ;15(2):216-25. Epub 2016 Apr 28. PMID: 27125675

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor

[+]

Curcumol suppresses triple-negative breast cancer metastasis. Sep 30, 2020

Click here to read the entire abstract

Pubmed Data : Anticancer Res. 2020 Oct ;40(10):5529-5538. PMID: 32988876

Article Published Date : Sep 30, 2020

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents

[+]

Curcumol, isolated from Curcuma phaeocaulis (R. Curcumae) induces programmed cell death in human lung cancer cells. Feb 03, 2010

Click here to read the entire abstract

Pubmed Data : Med Oncol. 2010 Feb 3. Epub 2010 Feb 3. PMID: 20127426

Article Published Date : Feb 03, 2010

Study Type : In Vitro Study

Additional Links

Substances : Curcuma phaeocaulis, Curcumol

Diseases : Lung Cancer

Pharmacological Actions : Apoptotic

[+]

Effect of curcumol on the biological behavior of multiple myeloma cells.Jan 09, 2016

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 10 ;36(10):1229-1234. PMID: 30641012

Article Published Date : Jan 09, 2016

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Multiple Myeloma

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Histone methylatic modification mediates the tumor-suppressive activity of curcumol in hepatocellular carcinoma via an Hotair/EZH2 regulatory axis.Nov 14, 2021

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2021 Nov 15 ;280:114413. Epub 2021 Jul 12. PMID: 34265379

Article Published Date : Nov 14, 2021

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Liver Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative

[+]

Identification and validation nucleolin as a target of curcumol in nasopharyngeal carcinoma cells.Jan 29, 2018

Click here to read the entire abstract

Pubmed Data : J Proteomics. 2018 06 30 ;182:1-11. Epub 2018 Apr 22. PMID: 29684682

Article Published Date : Jan 29, 2018

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Nasopharyngeal Cancer

Pharmacological Actions : Antineoplastic Agents, Chemopreventive

[+]

Proteomic identification of eEF1A1 as a molecular target of curcumol for suppressing metastasis of MDA-MB-231 cells.Apr 11, 2017

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2017 Apr 12 ;65(14):3074-3082. Epub 2017 Mar 31. PMID: 28345336

Article Published Date : Apr 11, 2017

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Anti-metastatic, Antiproliferative

[+]

The reported data reveals multitarget activity of curcumol in cancer treatment.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Biol Sci. 2019 ;15(8):1600-1609. Epub 2019 Jun 4. PMID: 31360103

Article Published Date : Dec 31, 2018

Study Type : Review

Additional Links

Substances : Curcumol

Diseases : Cancers: All

Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Chemopreventive, NF-kappaB Inhibitor

[+]

These findings provided a promising option of curcumol to regulate cellular senescence by target YAP/NCOA4 for the treatment of NAFLD.Aug 02, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Prolif. 2021 Aug 3:e13107. Epub 2021 Aug 3. PMID: 34346124

Article Published Date : Aug 02, 2021

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

[+]

This provided a new theoretical basis for curcumol to ameliorate liver fibrosis.Nov 03, 2020

Click here to read the entire abstract

Pubmed Data : Life Sci. 2020 Nov 4:118696. Epub 2020 Nov 4. PMID: 33157090

Article Published Date : Nov 03, 2020

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Liver Fibrosis

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Fibrotic

[+]

This research demonstrated that curcumol reduced the proliferation of colorectal cancer cells.Mar 14, 2019

Click here to read the entire abstract

Pubmed Data : Life Sci. 2019 Mar 15 ;221:354-361. Epub 2019 Feb 24. PMID: 30811964

Article Published Date : Mar 14, 2019

Study Type : In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, MicroRNA modulator

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View the Evidence: 45 Abstracts with Curcumol Research

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A potential anti-liver fibrosis mechanism of curcumol may be associated with the inhibition of NLRP3 inflammasomes.Jul 27, 2021

Curcumol ameliorates lung inflammation and airway remodeling.Dec 31, 2020

Curcumol attenuates epithelial-mesenchymal transition of nasopharyngeal carcinoma cells via TGF-β1.May 31, 2018

Curcumol controls choriocarcinoma stem-like cells self-renewal.Jan 23, 2018

Curcumol could suppress the growth of human colorectal cancer xenografts in vivo.Dec 31, 2014

Curcumol exhibited time and concentration dependent anti-proliferative and apoptosis-inductive activities in SPC-A-1human lung adenocarcinoma cells.Dec 31, 2014

Curcumol may be a potential compound for use in the development of novel triple-negative breast cancer therapeutics.Jun 30, 2017

Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.Jan 26, 2020

Curcumol might represent a promising lead compound for the development of new targeted anti-cancer therapeutics.Apr 08, 2020

Curcumol promotes vascular endothelial growth factor-mediated diabetic wound healing.Jan 30, 2017

These results indicate the potential of curcumol in the prevention of colon cancer carcinogenesis.Jan 09, 2018

An overview of the therapeutic effects of curcumol in several diseases.Apr 13, 2020

Anti-proliferative benefit of curcumol on human bladder cancer cells via inactivating EZH2 effector.Jul 31, 2018

Blockade of periostin-dependent migration and adhesion by curcumol via inhibition of nuclear factor kappa B signaling in hepatic stellate cells.Dec 31, 2019

Curcumol alleviates the inflammation of nucleus pulposus cells via the PI3K/Akt/NF-κB signaling pathway and delays intervertebral disk degeneration.Aug 23, 2021

Curcumol and curcumin showed an anti-inflammatory effect by inhibiting the NF-κB signaling pathway.Dec 31, 2018

Curcumol and FTY720 synergistically induce apoptosis and differentiation in chronic myelomonocytic leukemia via multiple signaling pathways.Mar 31, 2021

Curcumol attenuates liver sinusoidal endothelial cell angiogenesis via regulating Glis-PROX1-HIF-1α in liver fibrosis.Feb 29, 2020

Curcumol combined with metformin may hold promise as a therapeutic strategy for triple-negative breast cancer.Jul 31, 2020

Curcumol demonstrated potential antitumor activities in MG-63 cells and may be used as a novel effective reagent in the treatment of osteosarcoma.Nov 30, 2017

Curcumol enhances the sensitivity of doxorubicin in triple-negative breast cancer.Jan 09, 2020

Curcumol exerts anticancer effect in cholangiocarcinoma cells.Dec 31, 2017

Curcumol improves cisplatin sensitivity of human gastric cancer cells through inhibiting PI3K/AKT pathway.Jul 25, 2020

Curcumol induces cell cycle arrest and apoptosis in human nasopharyngeal carcinoma CNE-2 cells.Oct 31, 2018

Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells.Jan 09, 2018

Curcumol inhibits EBV-positive Nasopharyngeal carcinoma migration and invasion by targeting nucleolin.Aug 20, 2021

Curcumol inhibits lung adenocarcinoma growth and metastasis.Jun 15, 2020

Curcumol inhibits the proliferation and metastasis of melanoma.Dec 31, 2019

Curcumol inhibits the proliferation of gastric adenocarcinoma MGC-803 cells via downregulation of IDH1.Nov 30, 2017

Curcumol inhibits the viability and invasion of colorectal cancer cells via miR-30a-5p and Hippo signaling pathway.Mar 31, 2021

Curcumol may alleviate psoriasis-like inflammation by inhibiting keratinocyte proliferation and inflammatory gene expression.Jan 26, 2021

Curcumol may be one of the mechanisms of antihepatic fibrosis by inhibiting the activity of the NF-κB signaling.Dec 31, 2019

Curcumol overcomes TRAIL resistance of non-small cell lung cancer.Oct 31, 2020

Curcumol potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer.Dec 28, 2017

Curcumol suppresses breast cancer cell metastasis.Dec 31, 2015

Curcumol suppresses triple-negative breast cancer metastasis. Sep 30, 2020

Curcumol, isolated from Curcuma phaeocaulis (R. Curcumae) induces programmed cell death in human lung cancer cells. Feb 03, 2010

Effect of curcumol on the biological behavior of multiple myeloma cells.Jan 09, 2016

Histone methylatic modification mediates the tumor-suppressive activity of curcumol in hepatocellular carcinoma via an Hotair/EZH2 regulatory axis.Nov 14, 2021

Identification and validation nucleolin as a target of curcumol in nasopharyngeal carcinoma cells.Jan 29, 2018

Proteomic identification of eEF1A1 as a molecular target of curcumol for suppressing metastasis of MDA-MB-231 cells.Apr 11, 2017

The reported data reveals multitarget activity of curcumol in cancer treatment.Dec 31, 2018

These findings provided a promising option of curcumol to regulate cellular senescence by target YAP/NCOA4 for the treatment of NAFLD.Aug 02, 2021

This provided a new theoretical basis for curcumol to ameliorate liver fibrosis.Nov 03, 2020

This research demonstrated that curcumol reduced the proliferation of colorectal cancer cells.Mar 14, 2019

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View the Evidence:
45 Abstracts with Curcumol Research