Curcumol

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43 Diseases Researched for Curcumol
NameACCKFocus
Colon Cancer315Locked
Liver Fibrosis1013Locked
Coronavirus Infection110Locked
Liver Cirrhosis68Locked
Breast Cancer: Triple Negative 67Locked
Liver Cancer56Locked
Lung Cancer56Locked
Nasopharyngeal Cancer56Locked
Colorectal Cancer45Locked
Prostate Cancer55Locked
Cancers: Drug Resistant44Locked
Gastric Cancer44Locked
Alcoholic Liver Disease13Locked
Asthma23Locked
Breast Cancer33Locked
Inflammation23Locked
Nonalcoholic fatty liver disease (NAFLD)23Locked
Oral Cancer13Locked
Squamous cell carcinoma13Locked
Animal Diseases: Infectious 12Locked
Carcinoma: Non-Small-Cell Lung22Locked
Chemically-Induced Liver Damage12Locked
Choriocarcinoma12Locked
Diabetic Complications12Locked
Glioma22Locked
Osteosarcoma22Locked
Pancreatic Cancer12Locked
Wound Healing12Locked
Arteriosclerosis11Locked
Bladder Cancer11Locked
Cancer Metastasis11Locked
Cancers: All11Locked
Cholangiocarcinoma11Locked
Chronic Myeloid Leukemia11Locked
Colorectal Cancer: Prevention 11Locked
Degenerative Disk Disease11Locked
Endometriosis11Locked
Head and Neck Cancer11Locked
Leiomyoma11Locked
Melanoma11Locked
Multiple Myeloma11Locked
Ovarian Cancer11Locked
Psoriasis11Locked
39 Pharmacological Actions Researched for Curcumol
NameACCKFocus
Antiproliferative 3744Locked
Apoptotic2731Locked
Hepatoprotective916Locked
Anti-Fibrotic1014Locked
Chemosensitizer1012Locked
Chemotherapeutic312Locked
Anti-metastatic1011Locked
Anti-Inflammatory Agents89Locked
Cell cycle arrest79Locked
MicroRNA modulator78Locked
NF-kappaB Inhibitor77Locked
Autophagy Up-regulation44Locked
Chemopreventive34Locked
Antineoplastic Agents33Locked
Epidermal growth factor receptor (EGFR) inhibitor13Locked
Angiogenesis Inducing Agents12Locked
Angiogenesis Inhibitors22Locked
Antiviral Agents12Locked
Bcl-2 protein down-regulation12Locked
Cyclin D1 Down-Regulation12Locked
Gastrointestinal Agents12Locked
Histone deacetylase inhibitor12Locked
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor12Locked
Interleukin-1 beta downregulation22Locked
Interleukin-6 Downregulation22Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor22Locked
P21 Activation12Locked
SIRT1 Activator12Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor22Locked
Tumor Suppressor Protein p53 Upregulation12Locked
Vascular Endothelial Growth Factor Regulator12Locked
Anti-Angiogenic11Locked
Anti-Asthmatic Agents11Locked
Antioxidants11Locked
Heme oxygenase-1 up-regulation11Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor11Locked
Nrf2 activation11Locked
STAT3 Inhibitor11Locked
Vasoprotective11Locked
Related Topics

Curcumol is a Sub of the following Topic

View the Evidence:
78 Abstracts with Curcumol Research

[+]

Therapeutic targets and functions of curcumol against COVID-19 and colon adenocarcinoma.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Nutr. 2022 ;9:961697. Epub 2022 Jul 29. PMID: 35967794
Article Published Date : Dec 31, 2021
Study Type : Human Study
Additional Links
Substances : Curcumol
Diseases : Colon Cancer, Coronavirus Infection
Pharmacological Actions : Chemotherapeutic
[+]

Curcumol exerts antitumor effect via inhibiting EGFR-Akt-Mcl-1 signaling. Mar 01, 2023

Pubmed Data : Am J Chin Med. 2023 Mar 2:1-20. Epub 2023 Mar 2. PMID: 36869017
Article Published Date : Mar 01, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor
[+]

Curcumol increases the sensitivity of colon cancer to 5-FU.Apr 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Transl Cancer Res. 2021 May ;10(5):2437-2450. PMID: 35116559
Article Published Date : Apr 30, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Colon Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

These findings suggest a promising use of curcumol in the treatment of alcoholic fatty liver disease.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:912825. Epub 2022 Jun 28. PMID: 35837283
Article Published Date : Dec 31, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Hepatoprotective
[+]

A potential anti-liver fibrosis mechanism of curcumol may be associated with the inhibition of NLRP3 inflammasomes.Jul 27, 2021

Pubmed Data : Chin J Integr Med. 2021 Jul 28. Epub 2021 Jul 28. PMID: 34319504
Article Published Date : Jul 27, 2021
Study Type : Animal Study
Additional Links
Substances : Curcumol
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PeerJ. 2022 ;10:e13376. Epub 2022 May 12. PMID: 35582617
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Curcumol
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, SIRT1 Activator
[+]

Curcumol ameliorates lung inflammation and airway remodeling.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2021 ;15:2641-2651. Epub 2021 Jun 21. PMID: 34188444
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Curcumol
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Curcumol attenuates epithelial-mesenchymal transition of nasopharyngeal carcinoma cells via TGF-β1.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2018 Jun ;17(6):7513-7520. Epub 2018 Mar 28. PMID: 29620189
Article Published Date : May 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic
[+]

Curcumol controls choriocarcinoma stem-like cells self-renewal.Jan 23, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2018 Jan 24 ;24:461-472. Epub 2018 Jan 24. PMID: 29363667
Article Published Date : Jan 23, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Choriocarcinoma
Pharmacological Actions : Histone deacetylase inhibitor
Additional Keywords : Cancer Stem Cells, Epigenetic Modification In Cancer
[+]

Curcumol could suppress the growth of human colorectal cancer xenografts in vivo.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2015 ;16(8):19851-67. Epub 2015 Aug 20. PMID: 26307972
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Curcumol exhibited time and concentration dependent anti-proliferative and apoptosis-inductive activities in SPC-A-1human lung adenocarcinoma cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(6):2307-12. PMID: 25824755
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Curcumol
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Dose Response, Selective Cytotoxicity
[+]

Curcumol inhibits encephalomyocarditis virus by promoting IFN-β secretion.Sep 29, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Vet Res. 2021 Sep 30 ;17(1):318. Epub 2021 Sep 30. PMID: 34587973
Article Published Date : Sep 29, 2021
Study Type : Animal Study
Additional Links
Substances : Curcumol
Diseases : Animal Diseases: Infectious
Pharmacological Actions : Antiviral Agents
[+]

Curcumol inhibits the growth of xenograft-tumors in mice and the biological activities of pancreatic cancer cells.May 31, 2022

Pubmed Data : Cell Cycle. 2022 Jun ;21(12):1249-1266. Epub 2022 Mar 6. PMID: 35253605
Article Published Date : May 31, 2022
Study Type : Animal Study
Additional Links
Substances : Curcumol
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , MicroRNA modulator
[+]

Curcumol may be a potential compound for use in the development of novel triple-negative breast cancer therapeutics.Jun 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2017 Jul ;14(1):1080-1088. Epub 2017 May 29. PMID: 28693277
Article Published Date : Jun 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.Jan 26, 2020

Pubmed Data : Phytother Res. 2020 Jan 27. Epub 2020 Jan 27. PMID: 31989700
Article Published Date : Jan 26, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Curcumol might represent a promising lead compound for the development of new targeted anti-cancer therapeutics.Apr 08, 2020

Pubmed Data : J Ethnopharmacol. 2020 Apr 9 ;257:112835. Epub 2020 Apr 9. PMID: 32278762
Article Published Date : Apr 08, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]

Curcumol promotes vascular endothelial growth factor-mediated diabetic wound healing.Jan 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2017 Jan 31 ;23:555-562. Epub 2017 Jan 31. PMID: 28138126
Article Published Date : Jan 30, 2017
Study Type : Animal Study
Additional Links
Substances : Curcumol
Diseases : Diabetic Complications, Wound Healing
Pharmacological Actions : Angiogenesis Inducing Agents, Vascular Endothelial Growth Factor Regulator
[+]

Effects of curcumol on liver function and fibrosis in rats of nonalcoholic fatty liver disease and its mechanism.Oct 31, 2021

Pubmed Data : Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2021 Nov ;37(6):611-615. PMID: 34821093
Article Published Date : Oct 31, 2021
Study Type : Animal Study
Additional Links
Substances : Curcumol
Diseases : Liver Cirrhosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Gut microbiota combined with metabolomics reveal the mechanism of curcumol on liver fibrosis.Jul 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2022 Aug ;152:113204. Epub 2022 May 30. PMID: 35653891
Article Published Date : Jul 31, 2022
Study Type : Animal Study
Additional Links
Substances : Curcumol
Diseases : Inflammation, Liver Cirrhosis
Pharmacological Actions : Gastrointestinal Agents, Hepatoprotective
[+]

These results indicate the potential of curcumol in the prevention of colon cancer carcinogenesis.Jan 09, 2018

Pubmed Data : J Ethnopharmacol. 2018 Jan 10 ;210:1-9. Epub 2017 Jul 4. PMID: 28684297
Article Published Date : Jan 09, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemopreventive, Cyclin D1 Down-Regulation, P21 Activation
[+]

A study on curcumol influencing proliferation and apoptosis of hepatocellular carcinoma cells.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2022 ;2022:9912776. Epub 2022 May 20. PMID: 35647179
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

An overview of the therapeutic effects of curcumol in several diseases.Apr 13, 2020

Pubmed Data : Nutr Cancer. 2020 Apr 14:1-15. Epub 2020 Apr 14. PMID: 32285707
Article Published Date : Apr 13, 2020
Study Type : Review
Additional Links
Substances : Curcumol
Diseases : Breast Cancer, Colorectal Cancer, Head and Neck Cancer, Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Anti-proliferative benefit of curcumol on human bladder cancer cells via inactivating EZH2 effector.Jul 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Aug ;104:798-805. Epub 2018 May 29. PMID: 29852354
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Bladder Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Blockade of periostin-dependent migration and adhesion by curcumol via inhibition of nuclear factor kappa B signaling in hepatic stellate cells.Dec 31, 2019

Pubmed Data : Toxicology. 2020 07 ;440:152475. Epub 2020 Apr 25. PMID: 32344006
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor
[+]

Curcumol alleviates liver fibrosis through inducing autophagy and ferroptosis in hepatic stellate cells.Nov 30, 2022

Pubmed Data : FASEB J. 2022 Dec ;36(12):e22665. PMID: 36398583
Article Published Date : Nov 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Curcumol alleviates the inflammation of nucleus pulposus cells via the PI3K/Akt/NF-κB signaling pathway and delays intervertebral disk degeneration.Aug 23, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World Neurosurg. 2021 Aug 24. Epub 2021 Aug 24. PMID: 34450323
Article Published Date : Aug 23, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumol and curcumin showed an anti-inflammatory effect by inhibiting the NF-κB signaling pathway.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:3035125. Epub 2019 Mar 17. PMID: 31007701
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Curcumol
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Curcumol and FTY720 synergistically induce apoptosis and differentiation in chronic myelomonocytic leukemia via multiple signaling pathways.Mar 31, 2021

Pubmed Data : Phytother Res. 2021 Apr ;35(4):2157-2170. Epub 2020 Dec 4. PMID: 33274566
Article Published Date : Mar 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Chronic Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Curcumol attenuates endometriosis by inhibiting the JAK2/STAT3 signaling pathway.Mar 12, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2022 Mar 13 ;28:e934914. Epub 2022 Mar 13. PMID: 35279667
Article Published Date : Mar 12, 2022
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Endometriosis
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumol attenuates human uterine leiomyoma cell development.Jun 27, 2023

Pubmed Data : J Ethnopharmacol. 2023 Jun 28 ;310:116311. Epub 2023 Mar 7. PMID: 36894110
Article Published Date : Jun 27, 2023
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Leiomyoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, NF-kappaB Inhibitor
[+]

Curcumol attenuates liver sinusoidal endothelial cell angiogenesis via regulating Glis-PROX1-HIF-1α in liver fibrosis.Feb 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Prolif. 2020 Mar ;53(3):e12762. Epub 2020 Mar 2. PMID: 32119185
Article Published Date : Feb 29, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Angiogenic, Anti-Fibrotic
[+]

Curcumol can enhance glioma cell sensitivity to temozolomide.Oct 19, 2023

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2023 Oct 20 ;43(10):1697-1705. PMID: 37933645
Article Published Date : Oct 19, 2023
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Cancers: Drug Resistant, Glioma
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Temozolomide
[+]

Curcumol combined with metformin may hold promise as a therapeutic strategy for triple-negative breast cancer.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Transl Med. 2020 Aug ;8(15):946. PMID: 32953746
Article Published Date : Jul 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Curcumol demonstrated potential antitumor activities in MG-63 cells and may be used as a novel effective reagent in the treatment of osteosarcoma.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2017 Dec ;14(6):6387-6394. Epub 2017 Sep 21. PMID: 29151904
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Osteosarcoma
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
[+]

Curcumol enhances cisplatin sensitivity of gastric cancer.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bioengineered. 2022 05 ;13(5):11668-11683. PMID: 35510522
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Gastric Cancer
Pharmacological Actions : Chemosensitizer, MicroRNA modulator, NF-kappaB Inhibitor
[+]

Curcumol enhances the antitumor effect of lenvatinib on hepatocellular carcinoma cells.Dec 31, 2023

Pubmed Data : Discov Med. 2024 Jan ;36(180):199-208. PMID: 38273760
Article Published Date : Dec 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Curcumol enhances the sensitivity of doxorubicin in triple-negative breast cancer.Jan 09, 2020

Pubmed Data : Biochem Pharmacol. 2020 Jan 10 ;174:113795. Epub 2020 Jan 10. PMID: 31926937
Article Published Date : Jan 09, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , MicroRNA modulator
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Curcumol exerts anticancer effect in cholangiocarcinoma cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Physiol. 2018 ;9:234. Epub 2018 Mar 20. PMID: 29615928
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Cholangiocarcinoma
Pharmacological Actions : Antiproliferative , Cell cycle arrest
[+]

Curcumol improves cisplatin sensitivity of human gastric cancer cells through inhibiting PI3K/AKT pathway.Jul 25, 2020

Pubmed Data : Drug Dev Res. 2020 Jul 26. Epub 2020 Jul 26. PMID: 32715509
Article Published Date : Jul 25, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Cancers: Drug Resistant, Gastric Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Curcumol induces cell cycle arrest and apoptosis in human nasopharyngeal carcinoma CNE-2 cells.Oct 31, 2018

Pubmed Data : Phytother Res. 2018 Nov ;32(11):2214-2225. Epub 2018 Aug 2. PMID: 30069933
Article Published Date : Oct 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells.Jan 09, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Redox Biol. 2018 10 ;19:375-387. Epub 2018 Sep 7. PMID: 30237126
Article Published Date : Jan 09, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Curcumol inhibits breast cancer growth via NCL/ERα36 and the PI3K/AKT pathway.Jan 22, 2023

Pubmed Data : Food Funct. 2023 Jan 23 ;14(2):874-885. Epub 2023 Jan 23. PMID: 36537297
Article Published Date : Jan 22, 2023
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest
[+]

Curcumol inhibits EBV-positive Nasopharyngeal carcinoma migration and invasion by targeting nucleolin.Aug 20, 2021

Pubmed Data : Biochem Pharmacol. 2021 Aug 21 ;192:114742. Epub 2021 Aug 21. PMID: 34428442
Article Published Date : Aug 20, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Antiproliferative
[+]

Curcumol inhibits lung adenocarcinoma growth and metastasis.Jun 15, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Res. 2020 Jun 16. Epub 2020 Jun 16. PMID: 32886059
Article Published Date : Jun 15, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Lung Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Curcumol inhibits malignant biological behaviors and TMZ-resistance in glioma cells.Jan 04, 2021

Pubmed Data : Aging (Albany NY). 2021 11 5 ;13(21):24101-24116. Epub 2021 Nov 5. PMID: 34739394
Article Published Date : Jan 04, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Cancers: Drug Resistant, Glioma
Pharmacological Actions : Antiproliferative
Additional Keywords : Epigenetic Modification In Cancer
[+]

Curcumol inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells by suppressing ERK/CREB pathway.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Allergol Immunopathol (Madr). 2022 ;50(1):17-24. Epub 2022 Jan 1. PMID: 34873892
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Asthma
Pharmacological Actions : Anti-Asthmatic Agents, Antiproliferative
[+]

Curcumol inhibits the development of prostate cancer.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:9317402. Epub 2022 Jul 30. PMID: 35942374
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative
[+]

Curcumol inhibits the malignant progression of prostate cancer.Jan 10, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2021 11 ;46(5). Epub 2021 Sep 30. PMID: 34590156
Article Published Date : Jan 10, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , MicroRNA modulator
[+]

Curcumol inhibits the progression of hepatocellular carcinoma.Mar 31, 2024

Pubmed Data : Cancer Biother Radiopharm. 2024 Apr ;39(3):203-210. Epub 2024 Jan 5. PMID: 38181186
Article Published Date : Mar 31, 2024
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative
[+]

Curcumol inhibits the proliferation and metastasis of melanoma.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer. 2020 ;11(7):1679-1692. Epub 2020 Jan 14. PMID: 32194780
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Cancer Metastasis, Melanoma
Pharmacological Actions : Anti-metastatic, MicroRNA modulator
[+]

Curcumol inhibits the proliferation of gastric adenocarcinoma MGC-803 cells via downregulation of IDH1.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2017 Dec ;38(6):3583-3591. Epub 2017 Oct 12. PMID: 29039582
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Curcumol inhibits the viability and invasion of colorectal cancer cells via miR-30a-5p and Hippo signaling pathway.Mar 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2021 Apr ;21(4):299. Epub 2021 Feb 17. PMID: 33732375
Article Published Date : Mar 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , MicroRNA modulator
[+]

Curcumol may alleviate psoriasis-like inflammation by inhibiting keratinocyte proliferation and inflammatory gene expression.Jan 26, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging (Albany NY). 2021 07 27 ;13(14):18392-18403. Epub 2021 Jul 27. PMID: 34314383
Article Published Date : Jan 26, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Psoriasis
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , STAT3 Inhibitor
[+]

Curcumol may be a potential chemical candidate for treating 5-Fu-resistant colorectal cancer.. Feb 27, 2023

Pubmed Data : Am J Chin Med. 2023 Feb 28:1-18. Epub 2023 Feb 28. PMID: 36866798
Article Published Date : Feb 27, 2023
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Cancers: Drug Resistant, Colorectal Cancer: Prevention
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Curcumol may be one of the mechanisms of antihepatic fibrosis by inhibiting the activity of the NF-κB signaling.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:8590638. Epub 2020 May 28. PMID: 32595742
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Curcumol overcomes TRAIL resistance of non-small cell lung cancer.Oct 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Adv Sci (Weinh). 2020 Nov ;7(22):2002306. Epub 2020 Oct 15. PMID: 33240775
Article Published Date : Oct 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Lung Cancer
Pharmacological Actions : Chemotherapeutic
[+]

Curcumol potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer.Dec 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Dec 29 ;8(70):115526-115545. Epub 2017 Dec 14. PMID: 29383179
Article Published Date : Dec 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Apoptotic, Chemosensitizer, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Curcumol reduces lower limb arteriosclerosis in rats by inhibiting human arterial smooth muscle cell activity.May 31, 2024

Pubmed Data : Clin Exp Pharmacol Physiol. 2024 Jun ;51(6):e13867. PMID: 38684457
Article Published Date : May 31, 2024
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Arteriosclerosis
Pharmacological Actions : Vasoprotective
[+]

Curcumol regulates SDF-1α/CXCR4/NF-κB to play a therapeutic role in chronic atrophic gastritis and gastric cancer.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:3219001. Epub 2022 Sep 16. PMID: 36159583
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Gastric Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

Curcumol repressed cell proliferation and angiogenesis via SP1/mir-125b-5p/VEGFA axis in non-small cell lung cancer.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:1044115. Epub 2022 Nov 18. PMID: 36467048
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative
[+]

Curcumol simultaneously induces both apoptosis and autophagy in human nasopharyngeal carcinoma cells.Nov 30, 2021

Pubmed Data : Phytother Res. 2021 Dec ;35(12):7004-7017. Epub 2021 Nov 8. PMID: 34750896
Article Published Date : Nov 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation
[+]

Curcumol suppresses breast cancer cell metastasis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Cancer Ther. 2016 06 ;15(2):216-25. Epub 2016 Apr 28. PMID: 27125675
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
[+]

Curcumol suppresses triple-negative breast cancer metastasis. Sep 30, 2020

Pubmed Data : Anticancer Res. 2020 Oct ;40(10):5529-5538. PMID: 32988876
Article Published Date : Sep 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents
[+]

Curcumol synergizes with cisplatin in osteosarcoma.Jul 05, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2022 Jul 6 ;27(14). Epub 2022 Jul 6. PMID: 35889217
Article Published Date : Jul 05, 2022
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Osteosarcoma
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Curcumol targeting PAX8 inhibits ovarian cancer cell migration and invasion and increases chemotherapy sensitivity of niraparib.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Oncol. 2022 ;2022:3941630. Epub 2022 May 2. PMID: 35548853
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Ovarian Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemosensitizer
[+]

Curcumol, isolated from Curcuma phaeocaulis (R. Curcumae) induces programmed cell death in human lung cancer cells. Feb 03, 2010

Pubmed Data : Med Oncol. 2010 Feb 3. Epub 2010 Feb 3. PMID: 20127426
Article Published Date : Feb 03, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcuma phaeocaulis, Curcumol
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic
[+]

Effect of curcumol on the biological behavior of multiple myeloma cells.Jan 09, 2016

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 10 ;36(10):1229-1234. PMID: 30641012
Article Published Date : Jan 09, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Multiple Myeloma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.Dec 29, 2022

Pubmed Data : Biofactors. 2022 Dec 30. Epub 2022 Dec 30. PMID: 36585763
Article Published Date : Dec 29, 2022
Study Type : In Vitro Study
Additional Links
Substances : Curcumol, Icariin
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
Additional Keywords : Natural Substance Synergy
[+]

Histone methylatic modification mediates the tumor-suppressive activity of curcumol in hepatocellular carcinoma via an Hotair/EZH2 regulatory axis.Nov 14, 2021

Pubmed Data : J Ethnopharmacol. 2021 Nov 15 ;280:114413. Epub 2021 Jul 12. PMID: 34265379
Article Published Date : Nov 14, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

Icariin-curcumol reverses DTX resistance by inhibiting the PI3K-Akt signaling and the Warburg effect.Sep 01, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2023 Sep 2 ;23(1):190. Epub 2023 Sep 2. PMID: 37660001
Article Published Date : Sep 01, 2023
Study Type : In Vitro Study
Additional Links
Substances : Curcumol, Icariin
Diseases : Prostate Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Docetaxel
[+]

Icariin‑curcumol promotes ferroptosis in prostate cancer cells through Nrf2/HO‑1 signaling.Apr 30, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2024 May ;27(5):232. Epub 2024 Mar 26. PMID: 38628654
Article Published Date : Apr 30, 2024
Study Type : In Vitro Study
Additional Links
Substances : Curcumol, Icariin
Diseases : Prostate Cancer
Pharmacological Actions : Antioxidants, Antiproliferative , Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Identification and validation nucleolin as a target of curcumol in nasopharyngeal carcinoma cells.Jan 29, 2018

Pubmed Data : J Proteomics. 2018 06 30 ;182:1-11. Epub 2018 Apr 22. PMID: 29684682
Article Published Date : Jan 29, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Antineoplastic Agents, Chemopreventive
[+]

Proteomic identification of eEF1A1 as a molecular target of curcumol for suppressing metastasis of MDA-MB-231 cells.Apr 11, 2017

Pubmed Data : J Agric Food Chem. 2017 Apr 12 ;65(14):3074-3082. Epub 2017 Mar 31. PMID: 28345336
Article Published Date : Apr 11, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

Study on mechanism of curcumol against liver fibrosis based on autophagy and apoptosis of hepatic stellate cells.Jan 31, 2022

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2022 Feb ;47(3):730-736. PMID: 35178956
Article Published Date : Jan 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Apoptotic, Autophagy Up-regulation
[+]

The reported data reveals multitarget activity of curcumol in cancer treatment.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Sci. 2019 ;15(8):1600-1609. Epub 2019 Jun 4. PMID: 31360103
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Curcumol
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Chemopreventive, NF-kappaB Inhibitor
[+]

These findings provided a promising option of curcumol to regulate cellular senescence by target YAP/NCOA4 for the treatment of NAFLD.Aug 02, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Prolif. 2021 Aug 3:e13107. Epub 2021 Aug 3. PMID: 34346124
Article Published Date : Aug 02, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
[+]

This provided a new theoretical basis for curcumol to ameliorate liver fibrosis.Nov 03, 2020

Pubmed Data : Life Sci. 2020 Nov 4:118696. Epub 2020 Nov 4. PMID: 33157090
Article Published Date : Nov 03, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Fibrosis
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Fibrotic
[+]

This research demonstrated that curcumol reduced the proliferation of colorectal cancer cells.Mar 14, 2019

Pubmed Data : Life Sci. 2019 Mar 15 ;221:354-361. Epub 2019 Feb 24. PMID: 30811964
Article Published Date : Mar 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, MicroRNA modulator

Copyright: sommai / 123RF Stock Photo

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Toxic...and Don't Know?
Written by Capt. Randall
Ever since humans discovered fire, our activities have been releasing a "dog's breakfast" of unnatural chemistry. The list has grown to well over 75,000 free elements, compounds and pharmaceuticals. Many of these are acidic, electron-hungry oxidants and free radical generators.

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