Curcumol

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3 Diseases Researched for Curcumol
NameACCKFocus
Breast Cancer: Triple Negative 13Locked
Lung Cancer23Locked
Colorectal Cancer12Locked
5 Pharmacological Actions Researched for Curcumol
NameACCKFocus
Apoptotic48Locked
Antiproliferative 24Locked
Tumor Suppressor Protein p53 Upregulation13Locked
Bcl-2 protein down-regulation12Locked
Cell cycle arrest12Locked
Related Topics

Curcumol is a Sub of the following Topic

View the Evidence:
34 Abstracts with Curcumol Research

[+]

Curcumol attenuates epithelial-mesenchymal transition of nasopharyngeal carcinoma cells via TGF-β1.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2018 Jun ;17(6):7513-7520. Epub 2018 Mar 28. PMID: 29620189
Article Published Date : May 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic
[+]

Curcumol controls choriocarcinoma stem-like cells self-renewal.Jan 23, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2018 Jan 24 ;24:461-472. Epub 2018 Jan 24. PMID: 29363667
Article Published Date : Jan 23, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Choriocarcinoma
Pharmacological Actions : Histone deacetylase inhibitor
Additional Keywords : Cancer Stem Cells, Epigenetic Modification In Cancer
[+]

Curcumol could suppress the growth of human colorectal cancer xenografts in vivo.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2015 ;16(8):19851-67. Epub 2015 Aug 20. PMID: 26307972
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Curcumol exhibited time and concentration dependent anti-proliferative and apoptosis-inductive activities in SPC-A-1human lung adenocarcinoma cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(6):2307-12. PMID: 25824755
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Curcumol
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Dose Response, Selective Cytotoxicity
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Curcumol may be a potential compound for use in the development of novel triple-negative breast cancer therapeutics.Jun 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2017 Jul ;14(1):1080-1088. Epub 2017 May 29. PMID: 28693277
Article Published Date : Jun 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.Jan 26, 2020

Pubmed Data : Phytother Res. 2020 Jan 27. Epub 2020 Jan 27. PMID: 31989700
Article Published Date : Jan 26, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Curcumol might represent a promising lead compound for the development of new targeted anti-cancer therapeutics.Apr 08, 2020

Pubmed Data : J Ethnopharmacol. 2020 Apr 9 ;257:112835. Epub 2020 Apr 9. PMID: 32278762
Article Published Date : Apr 08, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]

Curcumol promotes vascular endothelial growth factor-mediated diabetic wound healing.Jan 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2017 Jan 31 ;23:555-562. Epub 2017 Jan 31. PMID: 28138126
Article Published Date : Jan 30, 2017
Study Type : Animal Study
Additional Links
Substances : Curcumol
Diseases : Diabetic Complications, Wound Healing
Pharmacological Actions : Angiogenesis Inducing Agents, Vascular Endothelial Growth Factor Regulator
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These results indicate the potential of curcumol in the prevention of colon cancer carcinogenesis.Jan 09, 2018

Pubmed Data : J Ethnopharmacol. 2018 Jan 10 ;210:1-9. Epub 2017 Jul 4. PMID: 28684297
Article Published Date : Jan 09, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemopreventive, Cyclin D1 Down-Regulation, P21 Activation
[+]

An overview of the therapeutic effects of curcumol in several diseases.Apr 13, 2020

Pubmed Data : Nutr Cancer. 2020 Apr 14:1-15. Epub 2020 Apr 14. PMID: 32285707
Article Published Date : Apr 13, 2020
Study Type : Review
Additional Links
Substances : Curcumol
Diseases : Breast Cancer, Colorectal Cancer, Head and Neck Cancer, Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Anti-proliferative benefit of curcumol on human bladder cancer cells via inactivating EZH2 effector.Jul 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Aug ;104:798-805. Epub 2018 May 29. PMID: 29852354
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Bladder Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Blockade of periostin-dependent migration and adhesion by curcumol via inhibition of nuclear factor kappa B signaling in hepatic stellate cells.Dec 31, 2019

Pubmed Data : Toxicology. 2020 07 ;440:152475. Epub 2020 Apr 25. PMID: 32344006
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor
[+]

Curcumol and curcumin showed an anti-inflammatory effect by inhibiting the NF-κB signaling pathway.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:3035125. Epub 2019 Mar 17. PMID: 31007701
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Curcumol
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Curcumol attenuates liver sinusoidal endothelial cell angiogenesis via regulating Glis-PROX1-HIF-1α in liver fibrosis.Feb 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Prolif. 2020 Mar ;53(3):e12762. Epub 2020 Mar 2. PMID: 32119185
Article Published Date : Feb 29, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Angiogenic, Anti-Fibrotic
[+]

Curcumol combined with metformin may hold promise as a therapeutic strategy for triple-negative breast cancer.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Transl Med. 2020 Aug ;8(15):946. PMID: 32953746
Article Published Date : Jul 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Curcumol demonstrated potential antitumor activities in MG-63 cells and may be used as a novel effective reagent in the treatment of osteosarcoma.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2017 Dec ;14(6):6387-6394. Epub 2017 Sep 21. PMID: 29151904
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Osteosarcoma
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
[+]

Curcumol enhances the sensitivity of doxorubicin in triple-negative breast cancer.Jan 09, 2020

Pubmed Data : Biochem Pharmacol. 2020 Jan 10 ;174:113795. Epub 2020 Jan 10. PMID: 31926937
Article Published Date : Jan 09, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , MicroRNA modulator
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Curcumol exerts anticancer effect in cholangiocarcinoma cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Physiol. 2018 ;9:234. Epub 2018 Mar 20. PMID: 29615928
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Cholangiocarcinoma
Pharmacological Actions : Antiproliferative , Cell cycle arrest
[+]

Curcumol improves cisplatin sensitivity of human gastric cancer cells through inhibiting PI3K/AKT pathway.Jul 25, 2020

Pubmed Data : Drug Dev Res. 2020 Jul 26. Epub 2020 Jul 26. PMID: 32715509
Article Published Date : Jul 25, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Cancers: Drug Resistant, Gastric Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Curcumol induces cell cycle arrest and apoptosis in human nasopharyngeal carcinoma CNE-2 cells.Oct 31, 2018

Pubmed Data : Phytother Res. 2018 Nov ;32(11):2214-2225. Epub 2018 Aug 2. PMID: 30069933
Article Published Date : Oct 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells.Jan 09, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Redox Biol. 2018 10 ;19:375-387. Epub 2018 Sep 7. PMID: 30237126
Article Published Date : Jan 09, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Curcumol inhibits lung adenocarcinoma growth and metastasis.Jun 15, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Res. 2020 Jun 16. Epub 2020 Jun 16. PMID: 32886059
Article Published Date : Jun 15, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Lung Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Curcumol inhibits the proliferation and metastasis of melanoma.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer. 2020 ;11(7):1679-1692. Epub 2020 Jan 14. PMID: 32194780
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Cancer Metastasis, Melanoma
Pharmacological Actions : Anti-metastatic, MicroRNA modulator
[+]

Curcumol inhibits the proliferation of gastric adenocarcinoma MGC-803 cells via downregulation of IDH1.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2017 Dec ;38(6):3583-3591. Epub 2017 Oct 12. PMID: 29039582
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Curcumol may be one of the mechanisms of antihepatic fibrosis by inhibiting the activity of the NF-κB signaling.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:8590638. Epub 2020 May 28. PMID: 32595742
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Curcumol potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer.Dec 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Dec 29 ;8(70):115526-115545. Epub 2017 Dec 14. PMID: 29383179
Article Published Date : Dec 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Apoptotic, Chemosensitizer, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Curcumol suppresses breast cancer cell metastasis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Cancer Ther. 2016 06 ;15(2):216-25. Epub 2016 Apr 28. PMID: 27125675
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
[+]

Curcumol suppresses triple-negative breast cancer metastasis. Sep 30, 2020

Pubmed Data : Anticancer Res. 2020 Oct ;40(10):5529-5538. PMID: 32988876
Article Published Date : Sep 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents
[+]

Curcumol, isolated from Curcuma phaeocaulis (R. Curcumae) induces programmed cell death in human lung cancer cells. Feb 03, 2010

Pubmed Data : Med Oncol. 2010 Feb 3. Epub 2010 Feb 3. PMID: 20127426
Article Published Date : Feb 03, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcuma phaeocaulis, Curcumol
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic
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Effect of curcumol on the biological behavior of multiple myeloma cells.Jan 09, 2016

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 10 ;36(10):1229-1234. PMID: 30641012
Article Published Date : Jan 09, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Multiple Myeloma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Identification and validation nucleolin as a target of curcumol in nasopharyngeal carcinoma cells.Jan 29, 2018

Pubmed Data : J Proteomics. 2018 06 30 ;182:1-11. Epub 2018 Apr 22. PMID: 29684682
Article Published Date : Jan 29, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Antineoplastic Agents, Chemopreventive
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Proteomic identification of eEF1A1 as a molecular target of curcumol for suppressing metastasis of MDA-MB-231 cells.Apr 11, 2017

Pubmed Data : J Agric Food Chem. 2017 Apr 12 ;65(14):3074-3082. Epub 2017 Mar 31. PMID: 28345336
Article Published Date : Apr 11, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

The reported data reveals multitarget activity of curcumol in cancer treatment.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Sci. 2019 ;15(8):1600-1609. Epub 2019 Jun 4. PMID: 31360103
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Curcumol
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Chemopreventive, NF-kappaB Inhibitor
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This research demonstrated that curcumol reduced the proliferation of colorectal cancer cells.Mar 14, 2019

Pubmed Data : Life Sci. 2019 Mar 15 ;221:354-361. Epub 2019 Feb 24. PMID: 30811964
Article Published Date : Mar 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, MicroRNA modulator

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Toxic...and Don't Know?
Written by Capt. Randall
Ever since humans discovered fire, our activities have been releasing a "dog's breakfast" of unnatural chemistry. The list has grown to well over 75,000 free elements, compounds and pharmaceuticals. Many of these are acidic, electron-hungry oxidants and free radical generators.

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