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EGCG (Epigallocatechin gallate)
Views 18914
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Focused Research Topics
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328 Diseases Researched for EGCG (Epigallocatechin gallate)
Name
AC
CK
Focus
Obesity
19
62
Breast Cancer
25
39
Cancers: All
30
38
Down Syndrome
7
33
Oxidative Stress
21
32
Lung Cancer
22
29
Inflammation
21
28
Prostate Cancer
16
26
Alzheimer's Disease
19
25
Breast Cancer: Triple Negative
5
24
Multiple Sclerosis
5
23
High Cholesterol
1
20
Atherosclerosis
7
19
Liver Cancer
15
18
Neurodegenerative Diseases
14
17
Cancers: Drug Resistant
14
16
Metabolic Syndrome X
5
16
Aging
4
15
Parkinson's Disease
11
15
Stroke: Attenuation/Recovery
4
15
High Fat Diet
7
14
Lipid Peroxidation
3
14
Arsenic Poisoning
7
13
Pancreatic Cancer
11
13
Brain Ischemia
2
12
Chemotherapy and Radiation Toxicity
2
12
Colorectal Cancer
7
12
Diabetes Mellitus: Type 2
7
12
Diabetic Complications
8
12
Brain Inflammation
8
11
Breast Cancer: Metastatic
2
11
MRSA
2
11
Melanoma
8
11
Scars
2
11
Staphylococcus aureus: Methicillin-resistant (MRSA)
2
11
Acne
1
10
Anogenital Warts
1
10
Cardiovascular Disease: Prevention
1
10
Cholesterol: High
1
10
Coronavirus Infection
9
10
Cystic Fibrosis
1
10
Dental Caries: Children
1
10
Elderly: Age Specific Diseases
1
10
Genital Warts
1
10
Herpes Simplex Virus Type 1
1
10
Multiple Sclerosis: Relapsing-Remitting
1
10
Overweight
1
10
Prostate: PSA Doubling
1
10
Rheumatoid Arthritis
7
10
Triglycerides: Elevated
1
10
Wound Healing
1
10
Head and Neck Cancer
6
9
Cervical Cancer
9
8
Colon Cancer
6
8
Human Papillomavirus (HPV)
6
8
Insulin Resistance
4
8
Lipopolysaccharide-Induced Toxicity
7
8
Ovarian Cancer
8
8
Air Pollution Linked Toxicity
2
7
Bladder Cancer
5
7
Cardiac Hypertrophy
4
7
Cardiovascular Diseases
6
7
Chemically-Induced Liver Damage
4
7
Advanced Glycation End products (AGE)
4
6
Autoimmune Diseases
4
6
Bisphenol Toxicity
4
6
Cancer Metastasis
4
6
Chemotherapy-Induced Toxicity: Cisplatin
3
6
Escherichia coli Infections
6
6
HIV Infections
6
6
Hyperglycemia
3
6
Influenza A
5
6
Kidney Damage
3
6
Sjogren's Syndrome
4
6
Alopecia
1
5
Amyotrophic Lateral Sclerosis
3
5
Brain: Oxidative Stress
4
5
Cancers: Multi-Drug Resistant
5
5
Chemotherapy-Induced Toxicity: Doxorubicin
4
5
Chlamydia pneumoniae
1
5
Diabetes Mellitus: Type 1
3
5
Diabetic Nephropathy
3
5
Hair Loss
1
5
Leiomyoma
3
5
Multiple Myeloma
4
5
Myocardial Ischemia
3
5
Oral Cancer
5
5
Osteoporosis
3
5
Prostatic Hyperplasia: Benign
3
5
Vitiligo
1
5
Acetaminophen (Tylenol) Toxicity
2
4
Asthma
2
4
Carcinoma: Non-Small-Cell Lung
3
4
Colitis
2
4
Erectile Dysfunction
2
4
Esophageal Cancer
4
4
Gastric Cancer
3
4
Glioblastoma
4
4
Hepatitis B
4
4
Hyperlipidemia
2
4
Hyperuricemia
2
4
Kidney Damage: Chemically-Induced
2
4
Kidney Diseases
2
4
Liver Damage: Drug-Induced
2
4
Muscle Atrophy
2
4
Nonalcoholic fatty liver disease (NAFLD)
2
4
Porphyromonas gingivalis
2
4
Pseudomonas aeruginosa
4
4
Salmonella Infections
3
4
Squamous cell carcinoma
3
4
Acinetobacter baumannii infection
3
3
Acrylamide-induced toxicity
2
3
Anthrax
2
3
Cancer Stem Cells
3
3
Carcinoma: Small Cell Lung
2
3
Cataract
3
3
Chemotherapy-Induced Toxicity: Gentamicin
2
3
Chronic Lymphocytic Leukemia
2
3
Clostridium Infections
2
3
Dry Eye Syndromes
2
3
Endometrial Cancer
3
3
Endotoxemia
2
3
Heart Failure
2
3
High Fructose Diet
2
3
Hypoglycemia
2
3
Inflammatory Bowel Diseases
2
3
Kidney Cancer
3
3
Liver Cancer: Prevention
2
3
Nasopharyngeal Cancer
2
3
Neuropathic Pain
2
3
Periodontal Diseases
2
3
Periodontitis
2
3
Pulmonary Fibrosis
2
3
Smoking
2
3
Steptococcus Mutans Infections
3
3
Thyroid Cancer
2
3
Aging Skin
1
2
Alcohol Toxicity
1
2
Alcoholic Liver Disease
1
2
Aluminum Toxicity
1
2
Aneurysm: Aortic
1
2
Anxiety
1
2
Arthritis
1
2
Arthritis: Rheumatoid
2
2
Asbestos Toxicity
2
2
Asthma: Bronchial
1
2
Autoimmune Thyroiditis
1
2
Benzo[a]pyrene-induced Toxicity
1
2
Bone Cancer
1
2
Brain Cancer
2
2
Brain Injury: Hippocampal Damage
1
2
C-Reactive Protein
1
2
Cadmium Poisoning
1
2
Cancers
2
2
Cardiac Mortality
1
2
Cardiomyopathy: Restrictive
1
2
Cerebral Hypoperfusion
1
2
Chemotherapy-Induced Toxicity: Bleomycin
1
2
Chemotherapy-Induced Toxicity: Irinotecan
1
2
Chikungunya Virus
2
2
Cholangiocarcinoma
2
2
Cholecystitis
1
2
Chronic Fatigue Syndrome
1
2
Chronic Pain
1
2
Cognitive Decline/Dysfunction
1
2
Coronary Artery Disease
1
2
Coronary Bypass Surgery
1
2
DNA damage
1
2
Diabetes Mellitus: Type 1: Prevention
1
2
Diabetes: Cardiovascular Illness
1
2
Diabetes: Oxidative Stress
1
2
Diabetic Retinopathy
2
2
Dysbiosis
1
2
Encephalomyelitis
2
2
Endothelial Dysfunction
2
2
Fatty Liver
1
2
Fetal Origin of Adult Disease
1
2
Fibroid Tumor
1
2
Fibroids: Uterine
1
2
Fish Diseases
1
2
Fluoride Toxicity
1
2
Gallbladder Inflammation
1
2
Gallstones
1
2
Gastrointestinal Inflammation
1
2
Gastrointestinal Stromal Tumors
1
2
Gestational Diabetes
1
2
Gingivitis
1
2
Glaucoma
1
2
Glioma
2
2
Glomerulonephritis
1
2
Gout
1
2
Graft vs Host Disease
1
2
H1N1 Infection
2
2
Hepatitis C
2
2
High Sugar Diet
2
2
Huntington Disease
1
2
Hypertension
2
2
Hypoxia
2
2
Infection: Antibiotic Resistant
2
2
Inflammation: Neutrophil-Mediated
1
2
Influenza
2
2
Influenza B
2
2
Ischemia
1
2
Learning disorders
1
2
Leiomyosarcoma
2
2
Leukemia: Acute promyelocytic leukemia
2
2
Leukemia: Chronic Lymphocytic Leukemia (CLL)
2
2
Leukemia: T-cell acute Lymphoblastic
2
2
Liver Fibrosis
2
2
Lung Injury: Acute
1
2
Melanoma: Metastatic
1
2
Memory Loss
1
2
Middle Cerebral Artery Occlusion (MCAO)
1
2
Mitochondrial Dysfunction
2
2
Mobile Phone-Induced Oxidative Stress
1
2
Morphine Tolerance/Dependence
1
2
Muscular Dystrophies
1
2
Myocardial Fibrosis
1
2
Neural Tube Defects
1
2
Neuroblastoma
2
2
Nicotine/Tobacco Toxicity
1
2
Non-Hodgkin's lymphoma: B Cell
2
2
Obstructive Nephropathy
1
2
Osteoarthritis
2
2
Osteosarcoma
2
2
Peripheral Nerve Diseases
1
2
Retinal Diseases
1
2
Sciatica
1
2
Sepsis
1
2
Skin Cancer
2
2
Skin Diseases: Photo-Aging
1
2
Staphylococcus aureus infection
2
2
Tardive Dyskinesia
1
2
Testicular Injury: Chemical/Metal Induced
1
2
Thyroiditis: Autoimmune
1
2
Tongue Cancer
1
2
Uveitis
1
2
Williams Syndrome
1
2
Wound Healing: Delayed
1
2
Xeroderma Pigmentosum
1
2
Acanthamoeba infection
1
1
Acid Reflux
1
1
Aging: Brain
1
1
Allergies
1
1
Amyloidosis
1
1
Animal Diseases: Porcine Circovirus Type 2 (PCV2)
1
1
Atrial Fibrillation
1
1
Bacterial Infections
1
1
Bacterial Infections and Mycoses
1
1
Barrett Esophagus
1
1
Bile Duct Cancer
1
1
Breast Cancer Stem Cells
1
1
Burkitt Cell Leukemia
1
1
Burns
1
1
Candida Infection
1
1
Cerebral Stroke
1
1
Cholesterol: Oxidation
1
1
Choriocarcinoma
1
1
Chronic Myeloid Leukemia
1
1
Degenerative Disk Disease
1
1
Dengue
1
1
Dengue Fever
1
1
Depression
1
1
Diabetes: Liver Disease
1
1
Drug-Induced Toxicity: Gastrointestinal
1
1
Drug-Induced Toxicity: Indomethacin
1
1
Ebola Virus Infections
1
1
Encephalitis: Japanese
1
1
Endometriosis
1
1
Epstein-Barr Virus Infections
1
1
Eye Diseases
1
1
Fibrosis: Liver
1
1
Follicular Lymphoma
1
1
Foodborne Pathogens: Prevention/Food Preservation
1
1
Fungal Infections: Biofilm Formation/Resistance
1
1
Gastrointestinal Diseases
1
1
H3N2 Infection
1
1
HSV-1
1
1
HSV-2
1
1
Halitosis
1
1
Hearing Loss
1
1
Helicobacter Pylori Infection
1
1
Herpes Simplex Virus Type 2
1
1
Human T-Cell Lymphotrophic Virus type 1 associated disease
1
1
Intestinal Permeability
1
1
Iron Overload
1
1
Keloid
1
1
Kidney Fibrosis
1
1
Leaky Gut Syndrome
1
1
Leukemia: Acute myelogenous leukemia (AML)
1
1
Leukemia: Chronic myelogenous leukemia (CML)
1
1
Liver Cancer: Metastatic
1
1
Liver Diseases
1
1
Lung Injury: Smoke-Induced
1
1
Lymphoma
1
1
Mastocytoma
1
1
Medulloblastoma
1
1
Mesothelioma
1
1
Metabolic Diseases
1
1
Mitochondrial Diseases
1
1
Multiple System Atrophy (MSA)
1
1
Myocardial Infarction
1
1
Nasopharyngeal Cancer Stem Cells
1
1
Neurologic Disorders
1
1
Non-Small-Cell Lung Carcinoma
1
1
Norovirus
1
1
Osteomyelitis
1
1
Pesticide Toxicity
1
1
Pituitary Diseases
1
1
Polio
1
1
Pre-Eclampsia
1
1
Prostate Cancer: Prevention
1
1
Rabies
1
1
Ricin Toxicity
1
1
Salivary Gland Adenoid Cystic Carcinoma.
1
1
Spinal Cord Injuries
1
1
Staphylococcus epidermidis
1
1
Stomach Cancer
1
1
Streptococcus pneumoniae infection
1
1
Stroke: Ischemic
1
1
Subarachnoid hemorrhage
1
1
Swine Flu Associated Virus
1
1
T-Cell Mediated Diseases
1
1
Testicular Cancer
1
1
Thrombocytopenia
1
1
Viral Infections
1
1
West Nile Fever
1
1
Zika Virus
1
1
119 Pharmacological Actions Researched for EGCG (Epigallocatechin gallate)
Name
AC
CK
Focus
Anti-Inflammatory Agents
83
146
Antiproliferative
83
130
Antioxidants
76
125
Apoptotic
79
120
Neuroprotective Agents
53
96
Chemopreventive
44
54
MicroRNA modulator
32
45
Anti-metastatic
27
42
Anticholesteremic Agents
4
42
Tumor Necrosis Factor (TNF) Alpha Inhibitor
22
41
Cardioprotective
21
39
Antiviral Agents
29
38
Interleukin-6 Downregulation
15
35
Immunomodulatory
22
34
Anti-Apoptotic
21
33
Chemosensitizer
22
31
Hypolipidemic
8
31
Anticarcinogenic Agents
21
27
Anti-Bacterial Agents
17
26
Chemotherapeutic
21
24
Hepatoprotective
14
24
NF-kappaB Inhibitor
18
24
Nrf2 activation
13
22
Antimicrobial
8
19
Renoprotective
10
19
Interleukin-1 beta downregulation
9
18
Matrix metalloproteinase-2 (MMP-2) inhibitor
7
18
Angiogenesis Inhibitors
11
17
Autophagy Up-regulation
6
15
Cell cycle arrest
12
13
Chemoprotective Agents
9
13
Matrix metalloproteinase-9 (MMP-9) inhibitor
3
13
Radioprotective
3
13
Vascular Endothelial Growth Factor Inhibitors
6
13
Anti-Anxiety Agents
2
12
Antineoplastic Agents
9
12
Hypoglycemic Agents
6
12
Interleukin-8 downregulation
7
12
Vascular Endothelial Growth Factor Regulator
3
12
Antihypertensive Agents
2
11
Radiosensitizer
2
11
Anti-Angiogenic
7
10
Heme oxygenase-1 up-regulation
6
10
Hepatocyte growth factor (HGF) inhibitor
1
10
Thermogenic
1
10
Tumor Suppressor Protein p53 Upregulation
6
9
Anti-Fibrotic
5
7
Anti-Glycation Agents
4
6
Gastrointestinal Agents
3
6
Immunomodulatory: Th17 downregulation
3
6
Multidrug Resistance Gene Modulators
6
6
Cyclooxygenase 2 Inhibitors
5
5
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
3
5
NF-E2-Related Factor-2 (Nrf2) Modulator
3
5
Neuritogenic
4
5
Anti-HIV Agents
4
4
Hypoxia-inducible factor-1 (HIF-1) inhibitor
2
4
P21 Activation
2
4
Prophylactic Agents
3
4
Quorum Sensing Inhibition
4
4
Regenerative
3
4
Telomerase Inhibitor
4
4
Uricosuric Agents
2
4
Wnt/β-catenin signaling pathway modulation
3
4
Anti-Proliferative
3
3
Cytoprotective
2
3
Epidermal growth factor receptor (EGFR) inhibitor
2
3
Gastroprotective
2
3
Gluconeogenesis Inhibitor
2
3
Glutathione Upregulation
2
3
Osteoprotective
2
3
STAT3 Inhibitor
2
3
Wnt/β-catenin pathway down-regulation
2
3
Aldose reductase inhibitor
1
2
Anti-Adipogenic
2
2
Antinoceceptive
1
2
Appetite Depressants
1
2
Bcl-2 protein down-regulation
2
2
Calcium Desensitizer
1
2
Genoprotective
1
2
Histone deacetylase inhibitor
2
2
Immunostimulatory
1
2
Insecticidal
1
2
Interleukin-10 upregulation
1
2
Interleukin-17 downregulation
1
2
Interleukin-2 Downregulation
1
2
Malondialdehyde Down-regulation
1
2
Matrix Metalloproteinases Inhibitors
1
2
Neurogenesis
1
2
Neurorestorative
1
2
Reverse Transcriptase Inhibitors
2
2
Telomere Protective
1
2
Vasodilator Agents
1
2
Viral Hemagglutinin Inhibitor
2
2
Xanthine oxidase inhibitor
1
2
AMP-activated protein kinase modulation
1
1
Adiponectin upregulation
1
1
Analgesics
1
1
Anti-Allergic Agents
1
1
Antidepressive Agents
1
1
Antifungal Agents
1
1
Antiparasitic Agents
1
1
Autophagy Inhibitors
1
1
Brain-derived neurotrophic factor modulator
1
1
Cell Differentiation Inducer
1
1
Chemotherapeuticm
1
1
Cyclooxygenase 1 Inhibitor
1
1
Drug synergy
1
1
Interleukin-10 downregulation
1
1
Ionophores
1
1
Iron Chelating Agents
1
1
Lactate Dehydrogenase A Inhibitor
1
1
Neurominidase Inhibitor
1
1
P38 Mitogen-Activated Protein Kinase Modulator
1
1
Pancreato Protective Agents
1
1
Prostaglandin Antagonists
1
1
Proteasome Inhibitors
1
1
Proton Pump Inhibitor
1
1
STAT3-NFκB Signaling: downregulation
1
1
Research Articles
605
Cumulative Knowledge Score
978
Overall Research Rating
EXCELLENT
Related Topics
EGCG (Epigallocatechin gallate) is a Sub of the following Topic
Green Tea
View the Evidence:
719 Abstracts with EGCG (Epigallocatechin gallate) Research
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[+]
Consumption of green tea EGCG resulted in a significant reduction of low-density lipoprotein cholesterol.
Jun 19, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Food Sci Nutr. 2016 Jun 20:1-8. Epub 2016 Jun 20. PMID:
27324590
Article Published Date
: Jun 19, 2016
Study Type
: Meta Analysis
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
High Cholesterol
Pharmacological Actions
:
Anticholesteremic Agents
[+]
Sulforaphane and EGCG restore estrogen receptor expression by modulating epigenetic events in the breast cancer cell line MDA-MB-231.
Oct 17, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Nutrigenet Nutrigenomics. 2017 Oct 18 ;10(3-4):126-135. Epub 2017 Oct 18. PMID:
29040973
Article Published Date
: Oct 17, 2017
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Sulforaphane
Diseases
:
Breast Cancer: Triple Negative
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Epigenetic Modification In Cancer
[+]
The effects of green tea on weight loss and weight maintenance.
Aug 31, 2009
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Obes (Lond). 2009 Sep ;33(9):956-61. Epub 2009 Jul 14. PMID:
19597519
Article Published Date
: Aug 31, 2009
Study Type
: Meta Analysis
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
A presurgical study of lecithin formulation of green tea extract in women with early breast cancer.
May 31, 2017
Click here to read the entire abstract
Pubmed Data
: Cancer Prev Res (Phila). 2017 Jun ;10(6):363-370. Epub 2017 Apr 11. PMID:
28400479
Article Published Date
: May 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
Additional Keywords
:
Plant Extracts
[+]
Addition of epigallocatechin gallate 400 mg to sofosbuvir 400 mg + daclatisvir 60 mg in in treatment of patients with chronic hepatitis C.
Jan 18, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2019 09 19 ;9(1):13593. Epub 2019 Sep 19. PMID:
31537880
Article Published Date
: Jan 18, 2019
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Hepatitis C
Pharmacological Actions
:
Antiviral Agents
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Administration of polyphenon E resulted in a therapeutic benefit for patients who were refractory to 5-aminosalicylic and/or azathioprine.
Jul 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Inflamm Bowel Dis. 2013 Aug ;19(9):1904-12. PMID:
23846486
Article Published Date
: Jul 31, 2013
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Gastrointestinal Agents
[+]
AverTeaX formulation containing lipophilic catechins effectively inhibited herpes simplex labialis infection with clinical significance.
Nov 30, 2015
Click here to read the entire abstract
Pubmed Data
: Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Dec ;120(6):717-24. Epub 2015 Sep 5. PMID:
26548726
Article Published Date
: Nov 30, 2015
Study Type
: Human Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
Diseases
:
Herpes Simplex Virus Type 1
Pharmacological Actions
:
Antiviral Agents
[+]
Both both zonal priming and direct EGCG application in scar therapy has positive effects on scar thickness, erythema, hydration and elasticity.
Feb 25, 2019
Click here to read the entire abstract
Pubmed Data
: J Invest Dermatol. 2019 Feb 26. Epub 2019 Feb 26. PMID:
30822414
Article Published Date
: Feb 25, 2019
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Scars
,
Wound Healing
[+]
Both EGCG and green tea could be used as alternatives to chlorhexidine-based mouthwashes.
Apr 18, 2020
Click here to read the entire abstract
Pubmed Data
: Arch Oral Biol. 2020 Apr 19 ;114:104727. Epub 2020 Apr 19. PMID:
32361019
Article Published Date
: Apr 18, 2020
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Dental Caries: Children
Pharmacological Actions
:
Antimicrobial
Additional Keywords
:
Mouthwash
[+]
Cysteamine plus epigallocatechin gallate can be used for autophagy-dependent rescue of class II-mutated CFTR.
Mar 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Death Differ. 2016 Apr 1. Epub 2016 Apr 1. PMID:
27035618
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study, Human Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cystic Fibrosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Autophagy Up-regulation
[+]
Decaffeinated green tea extract resulted in significant reductions in lesions located on the nose, perioral area and chin.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: Complement Ther Med. 2016 Apr ;25:159-63. Epub 2016 Mar 7. PMID:
27062963
Article Published Date
: Mar 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Acne
Additional Keywords
:
Plant Extracts
[+]
Decreases in inflammatory levels in patients with multiple sclerosis after treatment with epigallocatechin gallate and coconut oil.
Sep 15, 2021
Click here to read the entire abstract
Pubmed Data
: Nutrients. 2021 Sep 16 ;13(9). Epub 2021 Sep 16. PMID:
34579104
Article Published Date
: Sep 15, 2021
Study Type
: Human Study
Additional Links
Substances
:
Coconut Oil
,
EGCG (Epigallocatechin gallate)
Diseases
:
Inflammation
,
Multiple Sclerosis
,
Obesity
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Anti-Obesity Agents
[+]
Efficacy of EGCG in preventing dermatitis in patients with breast cancer receiving postoperative radiotherapy.
May 31, 2022
Click here to read the entire abstract
Pubmed Data
: JAMA Dermatol. 2022 Jun 1. Epub 2022 Jun 1. PMID:
35648426
Article Published Date
: May 31, 2022
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Breast Cancer
,
Dermatitis
,
Radiotherapy
Pharmacological Actions
:
Radioprotective
[+]
EGCG activated AMPK and insulin pathways, thereby promoting glycolysis, glycogen, and protein synthesis and inhibiting fatty acid and cholesterol synthesis.
Nov 16, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2021 Nov 17 ;13(11). Epub 2021 Nov 17. PMID:
34836374
Article Published Date
: Nov 16, 2021
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Hyperlipidemia
Pharmacological Actions
:
Hypoglycemic Agents
,
Hypolipidemic
Additional Keywords
:
Plant Extracts
[+]
EGCG and coconut oil improve state anxiety and functional capacity in patients with multiple sclerosis.
Jan 22, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2020 Jan 23 ;12(2). Epub 2020 Jan 23. PMID:
31979305
Article Published Date
: Jan 22, 2020
Study Type
: Human Study
Additional Links
Substances
:
Coconut Oil
,
EGCG (Epigallocatechin gallate)
Diseases
:
Multiple Sclerosis
Pharmacological Actions
:
Anti-Anxiety Agents
,
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
[+]
EGCG and cognitive training for 12 months led to an improving of visual recognition memory, inhibitory control, and adaptive behaviour.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Lancet Neurol. 2016 Jul ;15(8):801-10. PMID:
27302362
Article Published Date
: Jun 30, 2016
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Down Syndrome
Pharmacological Actions
:
Neuroprotective Agents
[+]
EGCG decreased skeletal muscle lactate concentrations in overweight individuals, suggesting a shift towards a more oxidative muscle phenotype.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2015 ;5:17896. Epub 2015 Dec 9. PMID:
26647963
Article Published Date
: Dec 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Additional Keywords
:
Supplementation
[+]
EGCG enhances fat oxidation in men and may contribute to the anti-obesity effects of green tea.
Oct 22, 2010
Click here to read the entire abstract
Pubmed Data
: J Biol Chem. 2010 Oct 22;285(43):33520-8. Epub 2010 Aug 18. PMID:
17906192
Article Published Date
: Oct 22, 2010
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Obesity
,
Overweight
Pharmacological Actions
:
Thermogenic
[+]
EGCG given to patients with multiple sclerosis over 12 weeks improved muscle metabolism during moderate exercise to a greater extent in men than in women.
Feb 28, 2015
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2015 Mar ;101(3):487-95. Epub 2015 Jan 14. PMID:
25733633
Article Published Date
: Feb 28, 2015
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Multiple Sclerosis
,
Multiple Sclerosis: Relapsing-Remitting
Therapeutic Actions
:
Exercise
Additional Keywords
:
Significant Treatment Outcome
[+]
EGCG supplementation may be improved blood pressure, lipid profile, AIP, and oxidative status in patients with T2DM.
Dec 24, 2020
Click here to read the entire abstract
Pubmed Data
: J Complement Integr Med. 2020 Dec 25 ;18(2):405-411. Epub 2020 Dec 25. PMID:
34187117
Article Published Date
: Dec 24, 2020
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Diabetes Mellitus: Type 2
,
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
,
Antioxidants
,
Hypolipidemic
[+]
Epigallocatechin gallate could potentially be used as a supplement of traditional rt-PA treatment among stroke patients.
Dec 08, 2016
Click here to read the entire abstract
Pubmed Data
: Clin Neuropharmacol. 2016 Dec 9. Epub 2016 Dec 9. PMID:
27941526
Article Published Date
: Dec 08, 2016
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Brain Ischemia
,
Stroke: Attenuation/Recovery
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Neuroprotective Agents
[+]
Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects.
Jan 11, 2020
Click here to read the entire abstract
Pubmed Data
: Exp Biol Med (Maywood). 2020 10 12:1535370220962708. Epub 2020 Oct 12. PMID:
33045853
Article Published Date
: Jan 11, 2020
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Obesity
Pharmacological Actions
:
Antihypertensive Agents
,
Hypolipidemic
[+]
Epigallocatechin gallate enhances treatment efficacy of oral nifedipine against pregnancy-induced severe pre-eclampsia.
Jan 31, 2018
Click here to read the entire abstract
Pubmed Data
: J Clin Pharm Ther. 2018 Feb ;43(1):21-25. Epub 2017 Jul 20. PMID:
28726273
Article Published Date
: Jan 31, 2018
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Hypertension
,
Pre-Eclampsia
Pharmacological Actions
:
Antihypertensive Agents
[+]
Epigallocatechin-3-gallate mouthwash protects mucosa from radiation-induced mucositis in head and neck cancer patients.
Dec 31, 2019
Click here to read the entire abstract
Pubmed Data
: Invest New Drugs. 2020 08 ;38(4):1129-1136. Epub 2019 Nov 7. PMID:
31701429
Article Published Date
: Dec 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Head and Neck Cancer
,
Radiation Induced Illness: Mucositis
Pharmacological Actions
:
Radioprotective
[+]
Green tea catechins are effective in reducing atherosclerosis risk associated with oxidative stress.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutr Res. 2016 Jan ;36(1):16-23. Epub 2015 Nov 3. PMID:
26773777
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Atherosclerosis
,
Lipid Peroxidation
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
Additional Keywords
:
Risk Reduction
[+]
Green tea catechins may have a therapeutic role in the treatment of metabolic syndrome.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: Phytochemistry. 2009 Jan;70(1):11-24. Epub 2009 Jan 13. PMID:
19147161
Article Published Date
: Jan 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Metabolic Syndrome X
[+]
Green tea polyphenon E and erlotinib combination was well tolerated in patients with APLs of the head and neck.
Jan 14, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Clin Cancer Res. 2020 11 15 ;26(22):5860-5868. Epub 2020 Sep 17. PMID:
32943457
Article Published Date
: Jan 14, 2020
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Head and Neck Cancer
Pharmacological Actions
:
Chemopreventive
[+]
High-dose green tea extract resulted in significant weight loss, reduced waist circumference, and a consistent decrease in total cholesterol and LDL plasma levels.
May 28, 2015
Click here to read the entire abstract
Pubmed Data
: Clin Nutr. 2015 May 29. Epub 2015 May 29. PMID:
26093535
Article Published Date
: May 28, 2015
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Cholesterol: High
,
Obesity
Pharmacological Actions
:
Anticholesteremic Agents
Additional Keywords
:
Anti-Obesity Agents
,
Significant Treatment Outcome
[+]
Improvements in gait and balance in patients with multiple sclerosis after treatment with coconut oil and epigallocatechin gallate.
Jan 22, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Food Funct. 2023 Jan 23 ;14(2):1062-1071. Epub 2023 Jan 23. PMID:
36594273
Article Published Date
: Jan 22, 2023
Study Type
: Human Study
Additional Links
Substances
:
Coconut Oil
,
EGCG (Epigallocatechin gallate)
Diseases
:
Multiple Sclerosis
[+]
It appears that EGCG should be taken without food in order to maximise its systemic absorption.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Antioxidants (Basel). 2015 ;4(2):373-93. Epub 2015 May 27. PMID:
26783711
Article Published Date
: Dec 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Additional Keywords
:
Bioavailability
[+]
Phase II trial of epigallocatechin-3-gallate in acute radiation-induced esophagitis for esophagus cancer.
Dec 31, 2019
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2020 Jan ;23(1):43-49. Epub 2019 Nov 20. PMID:
31747326
Article Published Date
: Dec 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Esophageal Cancer
,
Radiation
Pharmacological Actions
:
Radioprotective
[+]
Supplementation with green tea extract significantly reduced circulating triglycerides and LDL-cholesterol concentrations.
Nov 01, 2016
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2016 Nov 2. Epub 2016 Aug 2. PMID:
27806972
Article Published Date
: Nov 01, 2016
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Cardiovascular Disease: Prevention
,
Triglycerides: Elevated
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
Additional Keywords
:
Natural Substance/Drug Antagonism
,
Plant Extracts
Problem Substances
:
Statin Drugs
[+]
Tea polyphenol has potential to be a therapeutic adjuvant against human metastatic breast cancer.
Feb 01, 2012
Click here to read the entire abstract
Pubmed Data
: Curr Mol Med. 2012 Feb 1 ;12(2):163-76. PMID:
22280355
Article Published Date
: Feb 01, 2012
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Breast Cancer
,
Breast Cancer: Metastatic
Pharmacological Actions
:
Anti-metastatic
,
Radiosensitizer
Additional Keywords
:
Drug Synergy
[+]
Tea polyphenols (primarily EGCG), significantly reduce PSA, Hepatocyte growth factor, VEG in men with prostate cancer.
Jul 01, 2009
Click here to read the entire abstract
Pubmed Data
: Cancer Prev Res (Phila Pa). 2009 Jul;2(7):673-82. Epub 2009 Jun 19. PMID:
19542190
Article Published Date
: Jul 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
,
Polyphenols
Diseases
:
Prostate: PSA Doubling
,
Prostate Cancer
Pharmacological Actions
:
Hepatocyte growth factor (HGF) inhibitor
,
Vascular Endothelial Growth Factor Regulator
[+]
The association between green and black tea consumption on successful aging.
May 14, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2019 May 15 ;24(10). Epub 2019 May 15. PMID:
31096548
Article Published Date
: May 14, 2019
Study Type
: Human Study
Additional Links
Substances
:
Black Tea
,
Coffee
,
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Aging
[+]
The effect of (-)-epigallocatechin gallate as an adjunct to non-surgical periodontal treatment.
May 02, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Trials. 2022 May 3 ;23(1):368. Epub 2022 May 3. PMID:
35505441
Article Published Date
: May 02, 2022
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Periodontal Diseases
[+]
The inhalation of tea catechin appears to suppress MRSA infection in the elderly.
Feb 01, 2006
Click here to read the entire abstract
Pubmed Data
: J Am Med Dir Assoc. 2006 Feb;7(2):79-83. Epub 2005 Jul 22. PMID:
16461248
Article Published Date
: Feb 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
Diseases
:
Elderly: Age Specific Diseases
,
MRSA
,
Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions
:
Anti-Bacterial Agents
[+]
Topical EGCG may be an effective treatment for radiation-induced dermatitis and has acceptable toxicity.
May 19, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 May 20. Epub 2016 May 20. PMID:
27224910
Article Published Date
: May 19, 2016
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chemotherapy and Radiation Toxicity
Pharmacological Actions
:
Radioprotective
[+]
Topical epigallocatechin-3-gallate in the treatment of vitiligo.
Jul 31, 2021
Click here to read the entire abstract
Pubmed Data
: Australas J Dermatol. 2021 Aug ;62(3):e404-e407. Epub 2021 May 28. PMID:
34046892
Article Published Date
: Jul 31, 2021
Study Type
: Human Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
Diseases
:
Vitiligo
Pharmacological Actions
:
Dermatologic Agents
[+]
Topical green tea extract appears safe and effective in treating external anogenital warts.
Jan 01, 2006
Click here to read the entire abstract
Pubmed Data
: Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):85-90. Epub 2005 Oct 20. PMID:
21294779
Article Published Date
: Jan 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Anogenital Warts
,
Genital Warts
[+]
Twelve weeks of EGCG and resveratrol supplementation increased mitochondrial capacity and stimulated fat oxidation.
May 17, 2016
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2016 May 18. Epub 2016 May 18. PMID:
27194304
Article Published Date
: May 17, 2016
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Resveratrol
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
Usage of and attitudes about green tea extract and epigallocathechin-3-gallate as a therapy in individuals with Down syndrome.
Jul 31, 2019
Click here to read the entire abstract
Pubmed Data
: Complement Ther Med. 2019 Aug ;45:234-241. Epub 2019 Jul 2. PMID:
31331567
Article Published Date
: Jul 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Down Syndrome
[+]
Combinations of EGCG and anticancer compounds induced synergistic anticancer effects in vitro and in vivo experiments, and showed an average reduction in tumor volume by 70.3 %.
Aug 31, 2015
Click here to read the entire abstract
Pubmed Data
: J Cancer Res Clin Oncol. 2015 Sep ;141(9):1511-22. Epub 2014 Dec 28. PMID:
25544670
Article Published Date
: Aug 31, 2015
Study Type
: Animal Study, Human In Vitro
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Cancers: All
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Cancer Stem Cells
,
Natural Substance/Drug Synergy
[+]
EGCG protected against the effects of Dihydrotestosterone (DHT) by altering the miRNA expression profile in human dermal papilla cells.
May 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Ann Dermatol. 2016 Jun ;28(3):327-34. Epub 2016 May 25. PMID:
27274631
Article Published Date
: May 31, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Alopecia
,
Hair Loss
Pharmacological Actions
:
Anti-Apoptotic
,
MicroRNA modulator
[+]
Epigallocatechin gallate suppresses Chlamydia pneumoniae mediated IgE responses.
Jun 15, 2016
Click here to read the entire abstract
Pubmed Data
: Minerva Med. 2016 Jun 16. Epub 2016 Jun 16. PMID:
27309037
Article Published Date
: Jun 15, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chlamydia pneumoniae
Pharmacological Actions
:
Immunomodulatory
[+]
Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome.
Jan 01, 2013
Click here to read the entire abstract
Pubmed Data
: Biochim Biophys Acta. 2013 Jan 2. Epub 2013 Jan 2. PMID:
23291000
Article Published Date
: Jan 01, 2013
Study Type
: Human In Vitro
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Down Syndrome
Additional Keywords
:
Mitochondrial Biogenesis
[+]
Panaxadiol and Epigallocatechin Gallate have a synergistic apoptotic effect on human colorectal cancer cells.
May 08, 2012
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2012 May 8. Epub 2012 May 8. PMID:
22566066
Article Published Date
: May 08, 2012
Study Type
: Human In Vitro
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
,
Ginseng
,
Green Tea
,
Panaxadiol
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemosensitizer
Additional Keywords
:
Natural Substance Synergy
[+]
Punicalagin and EGCG can rescue keratinocyte viability and attenuate the inflammatory responses of cells due to airborne particles.
Mar 21, 2018
Click here to read the entire abstract
Pubmed Data
: Skin Pharmacol Physiol. 2018 Mar 22 ;31(3):134-143. Epub 2018 Mar 22. PMID:
29566388
Article Published Date
: Mar 21, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Punicalagin
Diseases
:
Air Pollution Linked Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Interleukin-8 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
These results provide new evidence for the effectiveness of EGCG in vitiligo treatment.
Sep 03, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biol Pharm Bull. 2015 Sep 4. Epub 2015 Sep 4. PMID:
26345342
Article Published Date
: Sep 03, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Vitiligo
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
VEGF is a key molecular target for specific polyphenols found in tea, apples and cocoa which potently inhibit VEGF signalling and angiogenesis at physiological concentrations.
Feb 28, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2015 Mar ;59(3):401-12. Epub 2015 Jan 22. PMID:
25546248
Article Published Date
: Feb 28, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Apple Polyphenols
,
EGCG (Epigallocatechin gallate)
,
Polyphenols
Diseases
:
Cancers: All
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Diet
[+]
A case of complete and durable molecular remission of chronic lymphocytic leukemia following treatment with epigallocatechin-3-gallate.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Cureus. 2015 ;7(12):e441. Epub 2015 Dec 29. PMID:
26858922
Article Published Date
: Dec 31, 2014
Study Type
: Human: Case Report
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chronic Lymphocytic Leukemia
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Cancer Remission
,
Significant Treatment Outcome
[+]
Epigallocatechin gallate but not catechin prevents nonalcoholic steatohepatitis in mice similar to green tea extract while differentially affecting the gut microbiota.
Jun 19, 2020
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2020 Jun 20 ;84:108455. Epub 2020 Jun 20. PMID:
32688217
Article Published Date
: Jun 19, 2020
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
[+]
Sex-specific oxidative damage effects induced by BPA and its analogs on primary hippocampal neurons attenuated by EGCG.
Sep 27, 2020
Click here to read the entire abstract
Pubmed Data
: Chemosphere. 2020 Sep 28 ;264(Pt 1):128450. Epub 2020 Sep 28. PMID:
33007573
Article Published Date
: Sep 27, 2020
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Bisphenol Toxicity
Problem Substances
:
Bisphenol A
Adverse Pharmacological Actions
:
Neurotoxic
[+]
The green tea polyphenol epigallocatechin-3-gallate attenuates age-associated muscle loss via regulation of miR-486-5p and myostatin.
Jul 21, 2020
Click here to read the entire abstract
Pubmed Data
: Arch Biochem Biophys. 2020 Jul 22 ;692:108511. Epub 2020 Jul 22. PMID:
32710883
Article Published Date
: Jul 21, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Muscle Atrophy
Pharmacological Actions
:
MicroRNA modulator
[+]
"Amelioration of influenza virus-induced reactive oxygen species formation by epigallocatechin gallate derived from green tea."
Nov 30, 2012
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2012 Dec ;33(12):1533-41. Epub 2012 Sep 3. PMID:
22941291
Article Published Date
: Nov 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Influenza A
[+]
"Green tea catechins ameliorates adipose Insulin resistance by improving oxidative stress."
Feb 11, 2012
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2012 Feb 11. Epub 2012 Feb 11. PMID:
22330066
Article Published Date
: Feb 11, 2012
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Antioxidants
[+]
"Green tea epigallocatechin-3-gallate (EGCG) promotes neural progenitor cell proliferation and sonic hedgehog pathway activation during adult hippocampal neurogenesis."
Jul 31, 2012
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2012 Aug ;56(8):1292-303. Epub 2012 Jun 13. PMID:
22692966
Article Published Date
: Jul 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Brain Injury: Hippocampal Damage
Pharmacological Actions
:
Neuritogenic
[+]
"Green tea epigallocatechin-3-gallate attenuates Porphyromonas gingivalis-induced atherosclerosis."
Sep 10, 2012
Click here to read the entire abstract
Pubmed Data
: FEMS Immunol Med Microbiol. 2012 Sep 11. Epub 2012 Sep 11. PMID:
22966806
Article Published Date
: Sep 10, 2012
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Atherosclerosis
,
Porphyromonas gingivalis
Pharmacological Actions
:
Cardioprotective
[+]
(-)-Epigallocatechin-3-gallate (EGCG) can inhibit the proliferation and invasiveness and induce apoptosis in nasopharyngeal carcinoma cells.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2015 ;16(2):2530-58. Epub 2015 Jan 23. PMID:
25625511
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Nasopharyngeal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
[+]
A combination of nutrients improves cognitive functioning while decreasing Alzheimer disease neuropathology in an animal model.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: PLoS One. 2010;5(11):e14015. Epub 2010 Nov 17. PMID:
21103342
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Alpha-Lipoic Acid
,
B-complex
,
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Folic Acid
,
NAC (N-acetyl-L-cysteine)
,
Piperine
,
Vitamin C
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
A major metabolite of EGCG increased the activity of CD4(+) T cells and enhanced the cytotoxic activity of NK cells in vivo.
May 10, 2016
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2016 May 11 ;64(18):3591-7. Epub 2016 May 2. PMID:
27112424
Article Published Date
: May 10, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Pharmacological Actions
:
Immunostimulatory
Additional Keywords
:
Metabolites
[+]
A quercetin, EGCG and apple polyphenol concentrate improved disorders of lipid metabolism and pro-oxidant-antioxidant homeostasis.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Wiad Lek. 2017;70(2):200-204. PMID:
28511159
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Apple Polyphenols
,
Catechin
,
EGCG (Epigallocatechin gallate)
,
Quercetin
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Natural Substance Synergy
,
Plant Extracts
[+]
Administration of Epigallocatechin-3-gallate resulted in a significant reduction in bone loss.
Sep 06, 2015
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2015 Sep 7. Epub 2015 Sep 7. PMID:
26359545
Article Published Date
: Sep 06, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Gingivitis
,
Periodontitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-17 downregulation
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
All these findings suggest that EGCG can resist skin senility effectively.
Mar 22, 2017
Click here to read the entire abstract
Pubmed Data
: Mech Ageing Dev. 2017 Mar 23. Epub 2017 Mar 23. PMID:
28343910
Article Published Date
: Mar 22, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Aging Skin
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Antimicrobial effect of Licochalcone A and Epigallocatechin-3-gallate against Salmonella Typhimurium isolated from poultry flocks.
Jan 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran J Microbiol. 2018 Feb ;10(1):51-58. PMID:
29922419
Article Published Date
: Jan 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Licorice
Diseases
:
Salmonella Infections
Pharmacological Actions
:
Antimicrobial
[+]
Artificial tears containing epigallocatechin gallate and hyaluronic acid had a synergistic effect in the treatment of dry eye syndrome.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016;11(6):e0157982. Epub 2016 Jun 23. PMID:
27336157
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Dry Eye Syndromes
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Interleukin-8 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Natural Substance Synergy
[+]
Attenuation of methotrexate induced hepatotoxicity by epigallocatechin 3-gallate.
Jun 13, 2022
Click here to read the entire abstract
Pubmed Data
: Drug Chem Toxicol. 2022 Jun 14:1-9. Epub 2022 Jun 14. PMID:
35698845
Article Published Date
: Jun 13, 2022
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chemically-Induced Liver Damage
,
Drug Toxicity: Methotrexate
Pharmacological Actions
:
Hepatoprotective
Problem Substances
:
Methotrexate
[+]
Beneficial impact of epigallocatechingallate on LDL-C through PCSK9/LDLR pathway by blocking HNF1α and activating FoxO3a.
May 11, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Transl Med. 2020 May 12 ;18(1):195. Epub 2020 May 12. PMID:
32398139
Article Published Date
: May 11, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cardiovascular Diseases
Pharmacological Actions
:
Anticholesteremic Agents
,
Cardioprotective
,
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]
Caffeine and EGCG alleviate high-trans fatty acid and high-carbohydrate diet-induced NASH.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Nutr. 2021 ;8:784354. Epub 2021 Nov 22. PMID:
34881283
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Caffeine
,
EGCG (Epigallocatechin gallate)
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
[+]
Catechin and EGCG could repair liver injury and regulate lipid metabolism of hepatocytes in alcoholic fatty liver disease mice models.
Nov 05, 2021
Click here to read the entire abstract
Pubmed Data
: Zhonghua Yu Fang Yi Xue Za Zhi. 2021 Nov 6 ;55(11):1305-1310. PMID:
34749473
Article Published Date
: Nov 05, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
Diseases
:
Alcoholic Liver Disease
Pharmacological Actions
:
Hepatoprotective
[+]
Chronic treatment of diabetic rats with EGCG could prevent the abnormal functional changes in vascular reactivity in diabetic rats.
Dec 01, 1975
Click here to read the entire abstract
Pubmed Data
: Am J Med Technol. 1975 Dec;41(12):457-62. PMID:
2010
Article Published Date
: Dec 01, 1975
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Diabetes: Cardiovascular Illness
Pharmacological Actions
:
Cardioprotective
[+]
Co-administration of EGCG and doxorubicin has potential as a feasible strategy to mitigate the drugs cardiotoxicity.
Dec 08, 2016
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2016 Dec 9. Epub 2016 Dec 9. PMID:
27956351
Article Published Date
: Dec 08, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cardioprotective
,
Chemoprotective Agents
Additional Keywords
:
Chemotherapeutic Synergy: Doxorubicin
[+]
Coadministration of epigallocatechin-3-gallate and caffeine in low dose ameliorates obesity and nonalcoholic fatty liver disease in obese rats.
Feb 10, 2019
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2019 Feb 11. Epub 2019 Feb 11. PMID:
30746789
Article Published Date
: Feb 10, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Caffeine
,
EGCG (Epigallocatechin gallate)
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
Additional Keywords
:
Anti-Obesity Agents
[+]
Combined treatment with the phenolics (-)-epigallocatechin-3-gallate and ferulic acid improves cognition and reduces Alzheimer-like pathology.
Jan 21, 2019
Click here to read the entire abstract
Pubmed Data
: J Biol Chem. 2019 02 22 ;294(8):2714-2731. Epub 2018 Dec 18. PMID:
30563837
Article Published Date
: Jan 21, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Ferulic acid
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Neuroprotective Agents
[+]
Consumption of green tea may be beneficial in alleviating some of the deleterious aspects of aging and immunosenescence in elderly.
Mar 23, 2017
Click here to read the entire abstract
Pubmed Data
: Biogerontology. 2017 Mar 24. Epub 2017 Mar 24. PMID:
28341876
Article Published Date
: Mar 23, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Aging
Pharmacological Actions
:
Antioxidants
,
Immunomodulatory
,
Interleukin-6 Downregulation
,
Malondialdehyde Down-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Curcumin as a permeability enhancer enhanced the antihyperlipidemic activity of dietary green tea extract.
Jun 12, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2019 Jun 13 ;19(1):129. Epub 2019 Jun 13. PMID:
31196040
Article Published Date
: Jun 12, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Catechin
,
Curcumin
,
EGCG (Epigallocatechin gallate)
Diseases
:
Hyperlipidemia
Pharmacological Actions
:
Antioxidants
,
Hypolipidemic
Additional Keywords
:
Natural Substance Synergy
[+]
Curcumin, resveratrol, and EGCG, repolarizes tumor-associated macrophages and triggers an immune response to cause suppression of HPV+ tumors.
Feb 15, 2018
Click here to read the entire abstract
Pubmed Data
: Cancer Immunol Immunother. 2018 Feb 16. Epub 2018 Feb 16. PMID:
29453519
Article Published Date
: Feb 15, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Resveratrol
Diseases
:
Head and Neck Cancer
,
Human Papillomavirus (HPV)
Pharmacological Actions
:
Immunomodulatory
Additional Keywords
:
Natural Substance Synergy
[+]
Daily consumption of EGCG might be effective in the prevention and treatment of secondary damage related to peripheral nerve injury.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Turk Neurosurg. 2015 ;25(3):453-60. PMID:
26037187
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Lipid Peroxidation
,
Peripheral Nerve Diseases
,
Sciatica
Pharmacological Actions
:
Antioxidants
[+]
Diallyl disulfide potentiates anti-obesity effect of green tea in high-fat/high-sucrose diet-induced obesity.
Dec 31, 2018
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2019 02 ;64:152-161. Epub 2018 Nov 3. PMID:
30504007
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
High Fat Diet
,
High Sugar Diet
,
Obesity
Additional Keywords
:
Anti-Obesity Agents
,
Natural Substance Synergy
[+]
Diet supplementation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in mice.
Feb 14, 2012
Click here to read the entire abstract
Pubmed Data
: Nutr Metab (Lond). 2012 Feb 14 ;9(1):11. Epub 2012 Feb 14. PMID:
22333133
Article Published Date
: Feb 14, 2012
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Diabetes Mellitus: Type 2
Additional Keywords
:
Beta Cell Protection
[+]
Diet supplemented with phytochemical epigallocatechin gallate and probiotic Lactobacillus fermentum confers second generation synbiotic effects.
Jan 02, 2019
Click here to read the entire abstract
Pubmed Data
: Eur J Nutr. 2019 Jan 3. Epub 2019 Jan 3. PMID:
30607562
Article Published Date
: Jan 02, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Lactobacillus fermentum
Diseases
:
Aging
Pharmacological Actions
:
Antioxidants
[+]
Dietary supplementation of a high-temperature-processed green tea extract attenuates cognitive impairment.
Aug 28, 2019
Click here to read the entire abstract
Pubmed Data
: Biosci Biotechnol Biochem. 2019 Aug 29:1-8. Epub 2019 Aug 29. PMID:
31462168
Article Published Date
: Aug 28, 2019
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Drinking green tea may reduce the toxic potential of acute high oral doses of EGCG supplementation.
Jan 31, 2015
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2015 Feb ;76:103-8. Epub 2014 Dec 17. PMID:
25528115
Article Published Date
: Jan 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Bioavailability
,
Natural Substance Synergy
,
Supplementation
[+]
ECG may be used as an anti-invasion agent for the adjuvant treatment and metastasis control of human lung cancer cells.
Jul 31, 2016
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2016 Aug ;94:1-10. Epub 2016 May 17. PMID:
27224248
Article Published Date
: Jul 31, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Lung Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Fibronectin
[+]
Effect of a cyclooxygenase-2 inhibitor in combination with (-)-epigallocatechin gallate or polyphenon E on cisplatin-induced lung tumorigenesis.
Jan 31, 2023
Click here to read the entire abstract
Pubmed Data
: Acta Med Okayama. 2023 Feb ;77(1):65-70. PMID:
36849147
Article Published Date
: Jan 31, 2023
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Lung Cancer
Pharmacological Actions
:
Chemotherapeutic
,
Cyclooxygenase 2 Inhibitors
[+]
Effects of flavonoids and Its derivatives on immune cell responses.
Dec 31, 2018
Click here to read the entire abstract
Pubmed Data
: Recent Pat Inflamm Allergy Drug Discov. 2019 ;13(2):84-104. PMID:
31814545
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Apigenin
,
EGCG (Epigallocatechin gallate)
,
Flavonoids
,
Quercetin
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Immunomodulatory
,
Interleukin-1 beta downregulation
,
Interleukin-2 Downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
EGCG administration had neurorestorative effects after bilateral common carotid artery occlusion.
Apr 10, 2016
Click here to read the entire abstract
Pubmed Data
: Restor Neurol Neurosci. 2016 Apr 11 ;34(3):367-77. PMID:
27080069
Article Published Date
: Apr 10, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cerebral Hypoperfusion
Pharmacological Actions
:
Neurorestorative
[+]
EGCG alleviates obesity-induced myocardial fibrosis.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Cardiovasc Med. 2022 ;9:869279. Epub 2022 Apr 29. PMID:
35571212
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Myocardial Fibrosis
Pharmacological Actions
:
Anti-Fibrotic
,
Cardioprotective
[+]
EGCG ameliorates lethal graft versus host disease and reduces related target organ damage.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2017 ;12(1):e0169630. Epub 2017 Jan 19. PMID:
28103249
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Graft vs Host Disease
Pharmacological Actions
:
Antioxidants
,
Immunomodulatory
Additional Keywords
:
Antioxidants
,
EGCG (Epigallocatechin gallate)
,
Graft vs Host Disease
,
Hematopoietic Stem Cells
,
Immunomodulatory
,
Risk Reduction
[+]
EGCG and CoQ10 ameliorate cisplatin induced nephrotoxicity.
Jun 01, 2016
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2016 Jun 2. Epub 2016 Jun 2. PMID:
27265264
Article Published Date
: Jun 01, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Coenzyme Q10
,
EGCG (Epigallocatechin gallate)
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Chemoprotective Agents
[+]
EGCG and ellagic acid have protective effects on cataract development via the inhibition of oxidative stress.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Ophthalmol. 2017 ;10(4):499-506. Epub 2017 Apr 18. PMID:
28503419
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Ellagic Acid
Diseases
:
Cataract
Pharmacological Actions
:
Antioxidants
[+]
EGCG appears to attenuate cardiopulmonary bypass-associated lung injury.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Surg Res. 2016 Apr ;201(2):313-25. Epub 2015 Nov 11. PMID:
27020813
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Coronary Bypass Surgery
,
Lung Injury: Acute
Additional Keywords
:
Risk Reduction
[+]
EGCG attenuated abdominal aortic aneurysm progression in a rat model by preserving the aortic thickness and elastin content of the medial layer.
May 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Vasc Surg. 2017 Jun ;65(6):1803-1812.e2. Epub 2016 Jul 26. PMID:
27473778
Article Published Date
: May 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Aneurysm: Aortic
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
EGCG can attenuate high-fat-induced hypothalamic inflammation.
Oct 12, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2019 Oct 13 ;20(20). Epub 2019 Oct 13. PMID:
31614951
Article Published Date
: Oct 12, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Brain Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
EGCG can be developed into a potential agent for the prevention and treatment of smoking‑associated NSCLC.
May 31, 2015
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2015 Jun ;33(6):2972-80. Epub 2015 Mar 31. PMID:
25845434
Article Published Date
: May 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Carcinoma: Small Cell Lung
,
Nicotine/Tobacco Toxicity
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-metastatic
,
Hypoxia-inducible factor-1 (HIF-1) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
EGCG can decrease obesity and epididymal white adipose tissue weight in mice.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2018 ;9:1366. Epub 2018 Nov 22. PMID:
30524290
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
EGCG can reduce lung injury and airway remodelling in air pollution-exposed asthmatic rats.
Apr 15, 2019
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2019 Apr 16. Epub 2019 Apr 16. PMID:
31003767
Article Published Date
: Apr 15, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Air Pollution Linked Toxicity
,
Asthma
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
EGCG consumption prevented diabetes-induced loss of cavernous smooth muscle.
May 11, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Impot Res. 2016 May 12. Epub 2016 May 12. PMID:
27169491
Article Published Date
: May 11, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Diabetes Mellitus: Type 1
,
Diabetic Complications
,
Erectile Dysfunction
[+]
EGCG could attenuate cadmium induced chronic renal injury.
Jul 25, 2016
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2016 Jul 26. Epub 2016 Jul 26. PMID:
27474435
Article Published Date
: Jul 25, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cadmium Poisoning
,
Kidney Damage: Chemically-Induced
Pharmacological Actions
:
MicroRNA modulator
,
Renoprotective
[+]
EGCG could attenuate Sodium arsenite-induced cardiotoxicity.
May 07, 2016
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2016 May 8. Epub 2016 May 8. PMID:
27170490
Article Published Date
: May 07, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Arsenic Poisoning
Pharmacological Actions
:
Cardioprotective
Problem Substances
:
Arsenite
[+]
EGCG could attenuate testosterone-induced benign prostatic hyperplasia and fibrosis.
Aug 31, 2018
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2018 Sep 1 ;64:162-169. Epub 2018 Sep 1. PMID:
30179845
Article Published Date
: Aug 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Prostatic Hyperplasia: Benign
Pharmacological Actions
:
Anti-Fibrotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]
EGCG could be coadministered with rt-PA, to extend its therapeutic window in treating acute brain ischemia.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Stroke Cerebrovasc Dis. 2016 Apr ;25(4):990-7. Epub 2016 Feb 3. PMID:
26851971
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Brain Ischemia
,
Stroke: Attenuation/Recovery
Pharmacological Actions
:
Neuroprotective Agents
[+]
EGCG could be used in the prevention or in the therapy of anthrax infections.
Mar 31, 2004
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: EMBO Rep. 2004 Apr ;5(4):418-22. Epub 2004 Mar 12. PMID:
15031715
Article Published Date
: Mar 31, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Anthrax
Pharmacological Actions
:
Anti-Apoptotic
,
Matrix Metalloproteinases Inhibitors
Additional Keywords
:
Anthrax Lethal Factor
[+]
EGCG could be useful for the prevention and treatment of rheumatoid arthritis and other inflammatory disorders.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Inflamm (Lond). 2015 ;12:53. Epub 2015 Sep 15. PMID:
26379475
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Heme oxygenase-1 up-regulation
,
Immunomodulatory
,
NF-E2-Related Factor-2 (Nrf2) Modulator
[+]
EGCG could have beneficial effects on neurogenesis and stroke recovery.
May 19, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Neurobiol. 2016 May 20. Epub 2016 May 20. PMID:
27206430
Article Published Date
: May 19, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Stroke: Attenuation/Recovery
Pharmacological Actions
:
Neurogenesis
[+]
EGCG could mitigate the teratogenic effects of hyperglycemia on the developing embryo and prevent diabetes-induced neural tube defects.
Mar 11, 2016
Click here to read the entire abstract
Pubmed Data
: Am J Obstet Gynecol. 2016 Mar 12. Epub 2016 Mar 12. PMID:
26979632
Article Published Date
: Mar 11, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Gestational Diabetes
,
Hyperglycemia
,
Neural Tube Defects
Additional Keywords
:
Hypomethylation
,
Methylation Downregulation
,
Risk Reduction
[+]
EGCG could potentially serve as an additional therapeutic intervention in the arsenal against obesity.
Feb 08, 2018
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2018 Feb 9. Epub 2018 Feb 9. PMID:
29423494
Article Published Date
: Feb 08, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
High Fat Diet
,
Insulin Resistance
,
Obesity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
Additional Keywords
:
Anti-Obesity Agents
[+]
EGCG could restore unilateral ureteral obstruction induced kidney weight loss and renal dysfunction in a mice model.
Jan 26, 2015
Click here to read the entire abstract
Pubmed Data
: Basic Clin Pharmacol Toxicol. 2015 Jan 27. Epub 2015 Jan 27. PMID:
25625183
Article Published Date
: Jan 26, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Obstructive Nephropathy
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
,
Renoprotective
Additional Keywords
:
Disease Reversal
[+]
EGCG decreased the arthritis index and showed protective effects against joint destruction in collagen-induced arthritis mice.
Mar 07, 2016
Click here to read the entire abstract
Pubmed Data
: J Leukoc Biol. 2016 Mar 8. Epub 2016 Mar 8. PMID:
26957211
Article Published Date
: Mar 07, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Heme oxygenase-1 up-regulation
,
Immunomodulatory: Th17 downregulation
,
NF-E2-Related Factor-2 (Nrf2) Modulator
,
STAT3 Inhibitor
[+]
EGCG decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion.
May 23, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2016 May 24. Epub 2016 May 24. PMID:
27218415
Article Published Date
: May 23, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Colitis
,
Gastrointestinal Inflammation
,
Inflammatory Bowel Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Macronutrient
[+]
EGCG decreases ovariectomy-induced bone loss via inhibition of osteoclasts.
Mar 21, 2012
Click here to read the entire abstract
Pubmed Data
: Calcif Tissue Int. 2012 Mar 21. Epub 2012 Mar 21. PMID:
22434366
Article Published Date
: Mar 21, 2012
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Osteoporosis
Additional Keywords
:
Ovariectomy-Induced Changes
[+]
EGCG dose-dependently improves insulin resistance in NAFLD mice
Apr 30, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Acta Pharmacol Sin. 2015 May ;36(5):597-605. Epub 2015 Apr 20. PMID:
25891086
Article Published Date
: Apr 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Hyperlipidemia
,
Hypoglycemia
,
Insulin Resistance
Pharmacological Actions
:
Hypoglycemic Agents
,
Hypolipidemic
Additional Keywords
:
Phytotherapy
[+]
EGCG enhanced the anti-tumor effect of doxorubicine in bladder cancer.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Cell Dev Biol. 2020 ;8:606123. Epub 2020 Dec 23. PMID:
33425912
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Chemosensitizer
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Chemotherapeutic Synergy: Doxorubicin
[+]
EGCG enhances 5FU sensitivity in chemoresistant colorectal cancer by targeting cancer stem cells.
Mar 28, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 Mar 29 ;7(13):16158-71. PMID:
26930714
Article Published Date
: Mar 28, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cancers: Drug Resistant
,
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Chemosensitizer
,
MicroRNA modulator
Additional Keywords
:
Cancer Stem Cells
,
Chemothapeutic Synergy: 5-flourouracil
[+]
EGCG exerts a neuroprotective effect on experimental autoimmune thyroiditis.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Jan ;15(1):1087-1092. Epub 2017 Nov 14. PMID:
29434699
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Autoimmune Thyroiditis
,
Thyroiditis: Autoimmune
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
[+]
EGCG exerts anti-inflammatory effect against monosodium urate induced acute gout attack.
May 27, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2016 May 28. Epub 2016 May 28. PMID:
27234527
Article Published Date
: May 27, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Gout
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
EGCG exhibits anti-fibrotic effects in a rat model of pulmonary fibrosis.
Jul 15, 2009
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2009 Jul 15;180(2):271-80. Epub 2009 Mar 20. PMID:
19497426
Article Published Date
: Jul 15, 2009
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chemotherapy-Induced Toxicity: Bleomycin
,
Pulmonary Fibrosis
[+]
EGCG from gestation to adulthood suppressed 3R-tau expression and rescued anxiety and memory deficits in Ts65Dn mouse brains.
Apr 03, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2017 Apr 4 ;7(1):619. Epub 2017 Apr 4. PMID:
28377597
Article Published Date
: Apr 03, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Down Syndrome
Pharmacological Actions
:
Neuroprotective Agents
[+]
EGCG has a beneficial effect on impaired adult neurogenesis caused by lipopolysaccharide induced neuro-inflammation.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Korean J Physiol Pharmacol. 2016 Jan ;20(1):41-51. Epub 2015 Dec 31. PMID:
26807022
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Brain Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
EGCG has a protective effect on rat brain injury induced by middle cerebral artery occlusion.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2018 ;2018:6473580. Epub 2018 Mar 25. PMID:
29770336
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions
:
Neuroprotective Agents
[+]
EGCG has an antiarthritic effect by regulating the oxidative-antioxidant balance and cytokine levels.
Nov 18, 2019
Click here to read the entire abstract
Pubmed Data
: Biotechnol Appl Biochem. 2019 Nov 19. Epub 2019 Nov 19. PMID:
31746064
Article Published Date
: Nov 18, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Heme oxygenase-1 up-regulation
,
Immunomodulatory: Th17 downregulation
,
Nrf2 activation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
EGCG has multifunctional therapeutic effects in the mouse model of ALS
Oct 01, 2006
Click here to read the entire abstract
Pubmed Data
: Neurochem Res. 2006 Oct;31(10):1263-9. Epub 2006 Oct 5. PMID:
17021948
Article Published Date
: Oct 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Amyotrophic Lateral Sclerosis
[+]
EGCG has significant antipathogenic effects on C. difficile.
Nov 30, 2015
Click here to read the entire abstract
Pubmed Data
: J Food Sci. 2015 Dec ;80(12):M2925-31. Epub 2015 Nov 10. PMID:
26556797
Article Published Date
: Nov 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Clostridium Infections
Pharmacological Actions
:
Antimicrobial
,
Gastroprotective
Additional Keywords
:
Gene Expression Regulation
[+]
EGCG has strong pharmacological activity against the development of morphine dependence.
Sep 01, 2007
Click here to read the entire abstract
Pubmed Data
: Arch Pharm Res. 2007 Sep;30(9):1111-5. PMID:
17958328
Article Published Date
: Sep 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Morphine Tolerance/Dependence
[+]
EGCG has the potential to ameliorate high fat and high fructose diet-triggered learning and memory loss.
Jul 23, 2017
Click here to read the entire abstract
Pubmed Data
: FASEB J. 2017 Jul 24. Epub 2017 Jul 24. PMID:
28739640
Article Published Date
: Jul 23, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
High Fat Diet
,
High Fructose Diet
,
Memory Loss
Pharmacological Actions
:
Neuroprotective Agents
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
EGCG has the potential to help control hyperglycemia, reduce weight, and alleviate diabetes complications.
Dec 28, 2016
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2016 Dec 29 ;87:73-81. Epub 2016 Dec 29. PMID:
28040599
Article Published Date
: Dec 28, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Advanced Glycation End products (AGE)
,
Diabetic Complications
,
Hyperglycemia
Pharmacological Actions
:
Anti-Glycation Agents
,
Hypoglycemic Agents
,
Hypolipidemic
[+]
EGCG improved lung damage in P. aeruginosa infection by inhibiting the production.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Microbiol. 2022 ;13:874354. Epub 2022 Apr 25. PMID:
35547130
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Lung Damage
,
Pseudomonas aeruginosa
Pharmacological Actions
:
Anti-Bacterial Agents
,
Anti-Inflammatory Agents
,
Interleukin-10 upregulation
,
Interleukin-17 downregulation
,
Interleukin-4 downregulation
,
Interleukin-6 Downregulation
,
Quorum Sensing Inhibition
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
EGCG induced a reduction in Aβ accumulation and elevated neprilysin expression in vitro.
May 14, 2015
Click here to read the entire abstract
Pubmed Data
: Exp Cell Res. 2015 May 15 ;334(1):136-45. Epub 2015 Apr 14. PMID:
25882496
Article Published Date
: May 14, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Pharmacological Actions
:
Neuroprotective Agents
[+]
EGCG induces miRNA profile changes in the NNK-induced A/J mouse lung tumor.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Genomics. 2014 ;15 Suppl 11:S3. Epub 2014 Dec 16. PMID:
25559244
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Lung Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
MicroRNA modulator
,
NF-kappaB Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
EGCG inhibited SW780 bladder cancer tumor growth by down-regulation of NF-κB and MMP-9.
Dec 19, 2016
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2016 Dec 20 ;41:56-64. Epub 2016 Dec 20. PMID:
28040581
Article Published Date
: Dec 19, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
[+]
EGCG inhibits arsenic-induced inflammation and apoptosis through suppression of oxidative stress in mice.
Apr 02, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2017 Apr 3 ;41(5):1788-1800. Epub 2017 Apr 3. PMID:
28365685
Article Published Date
: Apr 02, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Arsenic Poisoning
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
Problem Substances
:
Arsenic
[+]
EGCG inhibits fibroid tumors in quail.
Feb 01, 2008
Click here to read the entire abstract
Pubmed Data
: Nutr Res. 2008 Feb;28(2):92-7. PMID:
19083394
Article Published Date
: Feb 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Fibroid Tumor
,
Fibroids: Uterine
,
Leiomyoma
Pharmacological Actions
:
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
EGCG is a strong combination partner of gemcitabine reducing pancreatic cancer cell growth by suppressing glycolysis.
Oct 04, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancers (Basel). 2019 Oct 5 ;11(10). Epub 2019 Oct 5. PMID:
31590367
Article Published Date
: Oct 04, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemosensitizer
Additional Keywords
:
Cancer Glycolysis
,
Chemotherapeutic Synergy: Gemcitabine
[+]
EGCG is effective in inflammatory colitis because it reduces cellular and molecular inflammation, and reduces intestinal permeability.
Jul 28, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2019 Jul 29 ;11(8). Epub 2019 Jul 29. PMID:
31362373
Article Published Date
: Jul 28, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
EGCG may ameliorate diet-induced metabolic misalignment by regulating the rhythmic expression of the circadian clock genes in the liver and fat.
May 31, 2017
Click here to read the entire abstract
Pubmed Data
: Biochim Biophys Acta. 2017 Jun ;1863(6):1575-1589. Epub 2017 Apr 12. PMID:
28412321
Article Published Date
: May 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Metabolic Syndrome X
,
Obesity
Additional Keywords
:
Anti-Obesity Agents
,
Circadian Clock Proteins
,
Gene Expression Regulation
[+]
EGCG may be a useful adjuvant therapeutic agent for the treatment of breast cancer.
Apr 12, 2017
Click here to read the entire abstract
Pubmed Data
: Pharmacol Rep. 2017 Apr 13 ;69(5):924-928. Epub 2017 Apr 13. PMID:
28646740
Article Published Date
: Apr 12, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Breast Cancer
Pharmacological Actions
:
Apoptotic
,
Chemotherapeutic
Additional Keywords
:
Gene Expression Regulation
,
Natural Substances Versus Drugs
[+]
EGCG may be useful as an adjuvant therapy for bronchial asthma.
Nov 27, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Med. 2017 Nov 28. Epub 2017 Nov 28. PMID:
29207033
Article Published Date
: Nov 27, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Asthma: Bronchial
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
EGCG may be useful for reducing hepatotoxicity associated with oxidative stress
Jun 20, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2017 Jun 21. Epub 2017 Jun 21. PMID:
28658663
Article Published Date
: Jun 20, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Arsenic Poisoning
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
,
Nrf2 activation
Problem Substances
:
Arsenic
[+]
EGCG may possible have a clinically relevant therapeutic effect in preventing, delaying or even treating tardive dyskinesia.
Mar 31, 2015
Click here to read the entire abstract
Pubmed Data
: Pharmacol Biochem Behav. 2015 Apr ;131:71-6. Epub 2015 Feb 8. PMID:
25668129
Article Published Date
: Mar 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
Diseases
:
Lipid Peroxidation
,
Oxidative Stress
,
Tardive Dyskinesia
Pharmacological Actions
:
Antioxidants
[+]
EGCG may potentially inhibit aging-induced cardiac hypertrophy, fibrosis, and apoptosis, thereby preserving cardiac function.
Jan 31, 2018
Click here to read the entire abstract
Pubmed Data
: J Cardiovasc Pharmacol. 2018 Feb ;71(2):65-75. PMID:
29419571
Article Published Date
: Jan 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cardiac Hypertrophy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
EGCG may provide a potential therapeutic candidate for ALS as a disease-modifying agent.
Oct 01, 2007
Click here to read the entire abstract
Pubmed Data
: Biomed Res. 2007 Oct;28(5):261-6. PMID:
16356650
Article Published Date
: Oct 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Amyotrophic Lateral Sclerosis
[+]
EGCG may reduce atherosclerotic plaque and alleviate pathological damage in the cardiac tissue.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Contrast Media Mol Imaging. 2022 ;2022:8639139. Epub 2022 Jul 11. PMID:
35919501
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Coronary Artery Disease
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
,
Heme oxygenase-1 up-regulation
,
Nrf2 activation
[+]
EGCG may regenerate the HOCl-production of MPO which is known to be impaired at chronic inflammatory diseases like RA.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016 ;11(3):e0152518. Epub 2016 Mar 29. PMID:
27023113
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
EGCG may serve as a promising compound for regulating glucose homeostasis.
Apr 02, 2019
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2019 Apr 3 ;67(13):3651-3661. Epub 2019 Mar 21. PMID:
30875211
Article Published Date
: Apr 02, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Hyperglycemia
Pharmacological Actions
:
Hypoglycemic Agents
[+]
EGCG might be regarded as a prospective therapeutic candidate in modulating diabetic nephropathy.
Aug 20, 2017
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2017 Aug 21. Epub 2017 Aug 21. PMID:
28823168
Article Published Date
: Aug 20, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Fibrotic
,
Hypoglycemic Agents
[+]
EGCG might represent a new potential therapeutic or preventive approach to control white spot syndrome.
Jun 21, 2017
Click here to read the entire abstract
Pubmed Data
: Fish Shellfish Immunol. 2017 Jun 22. Epub 2017 Jun 22. PMID:
28648884
Article Published Date
: Jun 21, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Fish Diseases
Additional Keywords
:
Gene Expression Regulation
[+]
EGCG modulates the composition of the gut microbiota to protect against radiation-induced intestinal injury.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Oncol. 2022 ;12:848107. Epub 2022 Apr 11. PMID:
35480105
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Radiation
Pharmacological Actions
:
Gastroprotective
,
Radioprotective
[+]
EGCG modulates the reversal of gene silencing involved in colon carcinogenesis.
May 05, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 May 6. Epub 2016 May 6. PMID:
27167203
Article Published Date
: May 05, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
Additional Keywords
:
Dose Response
,
Epigenetic Modification In Cancer
,
Gene Expression Regulation
[+]
EGCG nanoparticles attenuate aluminum chloride induced neurobehavioral deficits.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Aging Neurosci. 2018 ;10:244. Epub 2018 Aug 13. PMID:
30150930
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Aluminum Toxicity
,
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
Problem Substances
:
Aluminum Chloride
[+]
EGCG possesses potent activity to attenuate lung injury during acute pancreatitis progression by inhibiting NLRP3 inflammasome activation.
May 20, 2021
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2021 May 21. Epub 2021 May 21. PMID:
34018522
Article Published Date
: May 20, 2021
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Lung Injury: Acute
,
Pancreatitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
EGCG potentially abrogates fluoride induced oxidative lung injury in rats.
Jul 25, 2016
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2016 Jul 26 ;39:128-139. Epub 2016 Jul 26. PMID:
27472294
Article Published Date
: Jul 25, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Fluoride Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Nrf2 activation
[+]
EGCG prevents cardiac hypertrophy induced by pressuer overload in rats.
Jun 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Vet Sci. 2007 Jun;8(2):121-9. PMID:
17519564
Article Published Date
: Jun 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cardiac Hypertrophy
[+]
EGCG promotes atherosclerotic lesion stability in apolipoprotein E-deficient mice.
Jun 03, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Kardiol Pol. 2018 Jun 4. Epub 2018 Jun 4. PMID:
29862488
Article Published Date
: Jun 03, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Coronary Artery Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
EGCG promotes PRKCA expression to alleviate LPS-induced acute lung injury and inflammatory response.
May 25, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2021 May 26 ;11(1):11014. Epub 2021 May 26. PMID:
34040072
Article Published Date
: May 25, 2021
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Lipopolysaccharide-Induced Toxicity
,
Lung Infection
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
EGCG protected against myocardial I/RI by modulating Gm4419/DUSP5/ERK1/2-mediated autophagy.
Nov 01, 2021
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2021 Nov 2 ;433:115782. Epub 2021 Nov 2. PMID:
34740634
Article Published Date
: Nov 01, 2021
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
EGCG protected outer hair cells from gentamicin toxicity in a cochlear explant model.
Sep 30, 2016
Click here to read the entire abstract
Pubmed Data
: Otol Neurotol. 2016 Oct ;37(9):1449-56. PMID:
27631653
Article Published Date
: Sep 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions
:
Antioxidants
,
Chemoprotective Agents
[+]
EGCG protects against muscle wasting disease, in a mouse model.
Apr 14, 2010
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2010 Apr 14;58(7):4523-8. PMID:
19322813
Article Published Date
: Apr 14, 2010
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Muscle Atrophy
,
Muscular Dystrophies
Pharmacological Actions
:
Glutathione Upregulation
[+]
EGCG protects the kidney in diabetic mice via anti-oxidative stress pathway.
May 09, 2016
Click here to read the entire abstract
Pubmed Data
: Zhonghua Yi Xue Za Zhi. 2016 May 10 ;96(17):1330-5. PMID:
27180749
Article Published Date
: May 09, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Diabetes: Oxidative Stress
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Antioxidants
,
Renoprotective
[+]
EGCG protects the mouse brain against cerebral ischemia/reperfusion injury.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2022 ;13:921394. Epub 2022 Sep 6. PMID:
36147330
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cerebral Ischemia
,
Stroke: Ischemic
Pharmacological Actions
:
Autophagy Inhibitors
,
Neuroprotective Agents
[+]
EGCG reduces the susceptibility to cholesterol gallstone formation through the regulation of inflammation.
Dec 01, 2008
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2008 Dec;62(10):677-83. Epub 2008 Jan 30. PMID:
18374538
Article Published Date
: Dec 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cholecystitis
,
Gallbladder Inflammation
,
Gallstones
[+]
EGCG reduces the testicular oxidative stress induced by arsenic poisoning and thereby protect the reproductive system.
Oct 12, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Oct 13 ;96:685-694. Epub 2017 Oct 13. PMID:
29040955
Article Published Date
: Oct 12, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Arsenic Poisoning
,
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Antioxidants
[+]
EGCG reversed GIO in rats by protecting osteoblasts by activating the Nrf2 signaling pathway.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2018 ;9:447. Epub 2018 May 9. PMID:
29867459
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Osteoporosis
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
,
Osteoprotective
[+]
EGCG sensitizes breast cancer cells to paclitaxel in a mouse model of breast carcinoma.
Jan 15, 2010
Click here to read the entire abstract
Pubmed Data
: Breast Cancer Res. 2010 Jan 15;12(1):R8. Epub 2010 Jan 15. PMID:
20078855
Article Published Date
: Jan 15, 2010
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Breast Cancer
Pharmacological Actions
:
Chemosensitizer
Additional Keywords
:
Drug: Paclitaxel
[+]
EGCG significantly inhibited gastric tumour growth in vivo by inhibiting Wnt/β-catenin signalling.
Jun 23, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Food Sci Nutr. 2016 Jun 24:1-10. Epub 2016 Jun 24. PMID:
27338284
Article Published Date
: Jun 23, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Antiproliferative
,
Chemopreventive
,
Wnt/β-catenin pathway down-regulation
[+]
EGCG supplement specifically counteracts daytime overeating induced by high fat diet in mice.
Jul 27, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2016 Jul 28. Epub 2016 Jul 28. PMID:
27468160
Article Published Date
: Jul 27, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
High Fat Diet
Pharmacological Actions
:
Appetite Depressants
Additional Keywords
:
Gene Expression Regulation
[+]
EGCG supplementation before radioiodine therapy could protect from RI-induced SG damage in a manner comparable to amifostine.
May 02, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Clin Exp Otorhinolaryngol. 2016 May 3. Epub 2016 May 3. PMID:
27136365
Article Published Date
: May 02, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chemotherapy and Radiation Toxicity
Pharmacological Actions
:
Radioprotective
Additional Keywords
:
Natural Substances Versus Drugs
[+]
EGCG treatment can decrease renal ischemia-reperfusion injury by suppressing inflammation and cell apoptosis.
Jun 27, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int Urol Nephrol. 2015 Jun 28. Epub 2015 Jun 28. PMID:
26122117
Article Published Date
: Jun 27, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Kidney Damage
,
Kidney Diseases
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Renoprotective
Additional Keywords
:
Significant Treatment Outcome
[+]
EGCG treatment led to a significant decrease in the protein levels of three Alzheimer’s disease relevant phospho-tau epitopes.
Jul 23, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Neurosci. 2015 Jul 24. Epub 2015 Jul 24. PMID:
26207957
Article Published Date
: Jul 23, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
MicroRNA modulator
,
Neuroprotective Agents
[+]
EGCG treatment was able to prevent the decreased locomotor activity as well as improve the learning and memory in SRs.
Jun 26, 2015
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2015 Jun 27 ;602:27-32. Epub 2015 Jun 27. PMID:
26126814
Article Published Date
: Jun 26, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Learning disorders
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
EGCG was able to exert anti-benign prostatic hyperplasia activities in metabolic syndrome rats.
Jun 14, 2016
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol Pharmacol. 2016 Jun 15 ;45:315-320. Epub 2016 Jun 15. PMID:
27348728
Article Published Date
: Jun 14, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Metabolic Syndrome X
,
Prostatic Hyperplasia: Benign
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hypoglycemic Agents
,
Hypolipidemic
[+]
EGCG, a green tea polyphenol, inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer in vivo.
Jan 01, 2008
Click here to read the entire abstract
Pubmed Data
: Front Biosci. 2008 Jan 1;13:440-52. PMID:
17981559
Article Published Date
: Jan 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Anti-Angiogenic
[+]
EGCG, a green tea polyphenol, prevents photocarcinogenesis in mice by enhancing DNA repair.
May 15, 2006
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2006 May 15;66(10):5512-20. PMID:
16707481
Article Published Date
: May 15, 2006
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Skin Diseases: Photo-Aging
,
Xeroderma Pigmentosum
[+]
EGCG, a green tea polyphenol, significantly interferes with androgen-independent prostate cancer in vivo.
Jan 01, 2008
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2008;60(4):483-91. PMID:
18584482
Article Published Date
: Jan 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Anti-Angiogenic
,
Apoptotic
Additional Keywords
:
Androgen-Independent Prostate Cancer
[+]
EGCG, a polyphenol from green tea, ameloriates chronic fatigue syndrome in mice.
Jul 27, 2009
Click here to read the entire abstract
Pubmed Data
: Behav Brain Res. 2009 Jul 27. PMID:
19643148
Article Published Date
: Jul 27, 2009
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chronic Fatigue Syndrome
[+]
EGCG-containing supplements may be important in correcting skeletal deficits associated with Down syndrome.
Jan 08, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2016 Jan 9. Epub 2016 Jan 9. PMID:
26748562
Article Published Date
: Jan 08, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Down Syndrome
Additional Keywords
:
Gene Expression Regulation
[+]
EGCG-induced vascular normalization in human lung adenocarcinoma may be a novel modality for enhancing chemotherapy effects.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Manag Res. 2019 ;11:2425-2439. Epub 2019 Mar 27. PMID:
30988640
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Lung Cancer
Pharmacological Actions
:
Chemotherapeutic
Additional Keywords
:
Chemotherapeutic Synergy: Cisplatin
[+]
EGCG3''Me supplemented diet produces promising effects on gut micro-ecology by enhancing beneficial microbial populations.
May 14, 2018
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2018 May 15:e1800274. Epub 2018 May 15. PMID:
29762899
Article Published Date
: May 14, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Obesity
Pharmacological Actions
:
Gastrointestinal Agents
[+]
Encapsulation of EGCG in transferrin-bearing vesicles is a promising therapeutic strategy.
Jan 31, 2013
Click here to read the entire abstract
Pubmed Data
: Nanomedicine (Lond). 2013 Feb ;8(2):181-92. Epub 2012 Aug 14. PMID:
22891867
Article Published Date
: Jan 31, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Melanoma
,
Squamous cell carcinoma
Pharmacological Actions
:
Antiproliferative
[+]
Epigallocatechin gallate (EGCG) alters body fat and lean mass through sex-dependent metabolic mechanisms in Drosophila melanogaster.
Apr 21, 2019
Click here to read the entire abstract
Pubmed Data
: Int J Food Sci Nutr. 2019 Apr 22:1-11. Epub 2019 Apr 22. PMID:
31010351
Article Published Date
: Apr 21, 2019
Study Type
: Insect Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.
Nov 30, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharm Biol. 2021 Dec ;59(1):1305-1313. PMID:
34607503
Article Published Date
: Nov 30, 2021
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cardiac Hypertrophy
,
Myocardial Fibrosis
Pharmacological Actions
:
Anti-Fibrotic
,
Cardioprotective
[+]
Epigallocatechin gallate (EGCG) reduces coronavirus replication.
Jan 16, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Viruses. 2021 12 17 ;13(12). Epub 2021 Dec 17. PMID:
34960802
Article Published Date
: Jan 16, 2021
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Coronavirus Infection
Pharmacological Actions
:
Antiviral Agents
[+]
Epigallocatechin gallate ameliorates airway inflammation by regulating Treg/Th17 imbalance in an asthmatic mouse model.
Apr 24, 2019
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2019 Apr 25 ;72:422-428. Epub 2019 Apr 25. PMID:
31030098
Article Published Date
: Apr 24, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Asthma
Pharmacological Actions
:
Immunomodulatory
,
Interleukin-10 upregulation
[+]
Epigallocatechin gallate and coenzyme Q10 attenuate cisplatin-induced hepatotoxicity.
Jan 03, 2021
Click here to read the entire abstract
Pubmed Data
: J Biochem Mol Toxicol. 2021 Jan 4:e22701. Epub 2021 Jan 4. PMID:
33393703
Article Published Date
: Jan 03, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Coenzyme Q10
,
EGCG (Epigallocatechin gallate)
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
,
Liver Damage: Drug-Induced
Pharmacological Actions
:
Chemoprotective Agents
,
Hepatoprotective
[+]
Epigallocatechin gallate and epicatechin gallate inhibited the cytotoxicity of acrylamide in PC12 cells.
Oct 25, 2017
Click here to read the entire abstract
Pubmed Data
: Drug Chem Toxicol. 2017 Oct 26:1-8. Epub 2017 Oct 26. PMID:
29072525
Article Published Date
: Oct 25, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Epicatechin
Diseases
:
Acrylamide-induced toxicity
Pharmacological Actions
:
Neuroprotective Agents
[+]
Epigallocatechin gallate and theaflavins independently alleviate cyclophosphamide-induced ovarian damage.
Oct 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Phytomedicine. 2021 Nov ;92:153752. Epub 2021 Sep 14. PMID:
34601223
Article Published Date
: Oct 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions
:
Chemoprotective Agents
[+]
Epigallocatechin gallate attenuates arsenic induced genotoxicity via regulation of oxidative stress.
Jul 25, 2019
Click here to read the entire abstract
Pubmed Data
: Mol Biol Rep. 2019 Jul 26. Epub 2019 Jul 26. PMID:
31350662
Article Published Date
: Jul 25, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Arsenic Poisoning
,
DNA damage
Pharmacological Actions
:
Antioxidants
,
Genoprotective
Problem Substances
:
Arsenic
[+]
Epigallocatechin gallate exerts protective effects against myocardial ischemia/reperfusion injury.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2016 Jul ;38(1):328-36. Epub 2016 May 31. PMID:
27246989
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Epigallocatechin gallate has a neurorescue effect in a mouse model of parkinson disease.
Aug 22, 2017
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2017 Aug 23. Epub 2017 Aug 23. PMID:
28835392
Article Published Date
: Aug 22, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Parkinson's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine‑induced liver cancer.
Oct 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2020 Nov ;22(5):3873-3885. Epub 2020 Aug 26. PMID:
33000276
Article Published Date
: Oct 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Liver Cancer
Pharmacological Actions
:
Chemopreventive
[+]
Epigallocatechin gallate prevents mitochondrial impairment and cell apoptosis.
Jan 29, 2019
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2019 Jan 30 ;61:152845. Epub 2019 Jan 30. PMID:
31029907
Article Published Date
: Jan 29, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
,
MicroRNA modulator
[+]
Epigallocatechin gallate reduces uric acid levels by regulating xanthine oxidase activity and uric acid excretion in vitro and in vivo.
Dec 21, 2019
Click here to read the entire abstract
Pubmed Data
: Ann Palliat Med. 2019 Dec 22. Epub 2019 Dec 22. PMID:
32008337
Article Published Date
: Dec 21, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Hyperuricemia
Pharmacological Actions
:
Uricosuric Agents
,
Xanthine oxidase inhibitor
[+]
Epigallocatechin gallate relieves asthmatic symptoms.
May 27, 2022
Click here to read the entire abstract
Pubmed Data
: Biochem Pharmacol. 2022 May 28:115112. Epub 2022 May 28. PMID:
35640712
Article Published Date
: May 27, 2022
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Asthma
Pharmacological Actions
:
Anti-Asthmatic Agents
,
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
,
Vascular Endothelial Growth Factor A Inhibitor
[+]
Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy.
Apr 26, 2017
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2017 Apr 27. Epub 2017 Apr 27. PMID:
28457936
Article Published Date
: Apr 26, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
[+]
Epigallocatechin gallate, a green tea phytochemical, attenuates alcohol-induced liver damage.
Jan 01, 2008
Click here to read the entire abstract
Pubmed Data
: Toxicol Mech Methods. 2008 Jan;18(8):645-52. PMID:
20020850
Article Published Date
: Jan 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Alcohol Toxicity
,
Alcoholic Liver Disease
Pharmacological Actions
:
Hepatoprotective
[+]
Epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways.
Aug 20, 2015
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2015 Aug 21. Epub 2015 Aug 21. PMID:
26386739
Article Published Date
: Aug 20, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Theaflavins
Diseases
:
Liver Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
,
Wnt/β-catenin signaling pathway modulation
[+]
Epigallocatechin-3-gallate (EGCG) improves cognitive deficits aggravated by an obesogenic diet.
Dec 13, 2019
Click here to read the entire abstract
Pubmed Data
: Mol Neurobiol. 2019 Dec 14. Epub 2019 Dec 14. PMID:
31838720
Article Published Date
: Dec 13, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Alzheimer's Disease
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Neuroprotective Agents
[+]
Epigallocatechin-3-gallate alleviates type 2 diabetes mellitus via β-cell function improvement and insulin resistance reduction.
Mar 31, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran J Basic Med Sci. 2022 Apr ;25(4):483-488. PMID:
35656076
Article Published Date
: Mar 31, 2022
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Diabetes Mellitus: Type 2
,
Insulin Resistance
Pharmacological Actions
:
Hypoglycemic Agents
,
Insulin Sensitizers
[+]
Epigallocatechin-3-gallate ameliorates atherosclerosis and modulates hepatic lipid metabolic gene expression.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2018 ;9:195. Epub 2018 Mar 9. PMID:
29593532
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
[+]
Epigallocatechin-3-gallate ameliorates erectile function in aged rats.
Apr 14, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Asian J Androl. 2016 Apr 15. Epub 2016 Apr 15. PMID:
27080477
Article Published Date
: Apr 14, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Erectile Dysfunction
[+]
Epigallocatechin-3-gallate ameliorates renal endoplasmic reticulum stress-mediated inflammation in type 2 diabetes.
Jun 30, 2022
Click here to read the entire abstract
Pubmed Data
: Exp Biol Med (Maywood). 2022 Jul 1:15353702221106479. Epub 2022 Jul 1. PMID:
35775606
Article Published Date
: Jun 30, 2022
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Diabetes Mellitus: Type 2
,
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Renoprotective
[+]
Epigallocatechin-3-gallate and related phenol compounds redirect the amyloidogenic aggregation pathway of ataxin-3 towards non-toxic aggregates.
Jun 14, 2017
Click here to read the entire abstract
Pubmed Data
: Hum Mol Genet. 2017 Jun 15. Epub 2017 Jun 15. PMID:
28633380
Article Published Date
: Jun 14, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Neurodegenerative Diseases
Pharmacological Actions
:
Neuroprotective Agents
[+]
Epigallocatechin-3-gallate attenuates myocardial fibrosis in diabetic rats by activating autophagy.
Jul 13, 2022
Click here to read the entire abstract
Pubmed Data
: Exp Biol Med (Maywood). 2022 Jul 14:15353702221110646. Epub 2022 Jul 14. PMID:
35833541
Article Published Date
: Jul 13, 2022
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Myocardial Fibrosis
Pharmacological Actions
:
Anti-Fibrotic
,
Cardioprotective
[+]
Epigallocatechin-3-gallate decreases hypoxia-inducible factor-1 in pancreatic cancer cells.
Mar 02, 2023
Click here to read the entire abstract
Pubmed Data
: Am J Chin Med. 2023 Mar 3:1-17. Epub 2023 Mar 3. PMID:
36867109
Article Published Date
: Mar 02, 2023
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]
Epigallocatechin-3-gallate exerts cardioprotective effects related to energy metabolism in pressure overload-induced cardiac dysfunction.
Jan 14, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Arch Biochem Biophys. 2022 07 15 ;723:109217. Epub 2022 Apr 13. PMID:
35427576
Article Published Date
: Jan 14, 2022
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Heart Failure
Pharmacological Actions
:
Cardioprotective
[+]
Epigallocatechin-3-gallate exerts protective effect on epithelial function.
Jul 21, 2022
Click here to read the entire abstract
Pubmed Data
: Microvasc Res. 2022 Jul 22 ;144:104408. Epub 2022 Jul 22. PMID:
35878868
Article Published Date
: Jul 21, 2022
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Venous Thrombosis
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
[+]
Epigallocatechin-3-gallate improves cardiac hypertrophy and short-term memory deficits in a Williams-Beuren syndrome mouse model.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2018 ;13(3):e0194476. Epub 2018 Mar 19. PMID:
29554110
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
Diseases
:
Cardiac Hypertrophy
,
Williams Syndrome
Pharmacological Actions
:
Neuroprotective Agents
[+]
Epigallocatechin-3-gallate inhibits angiotensin II-induced C-reactive protein generation.
Aug 03, 2016
Click here to read the entire abstract
Pubmed Data
: Naunyn Schmiedebergs Arch Pharmacol. 2016 Aug 4. Epub 2016 Aug 4. PMID:
27492718
Article Published Date
: Aug 03, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
C-Reactive Protein
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Epigallocatechin-3-gallate inhibits osteopontin expression and prevents experimentally induced hepatic fibrosis.
Jun 30, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Pharmacother. 2022 Jul ;151:113111. Epub 2022 May 17. PMID:
35594711
Article Published Date
: Jun 30, 2022
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Liver Fibrosis
Pharmacological Actions
:
Anti-Fibrotic
,
Antioxidants
,
Malondialdehyde Down-regulation
[+]
Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Cell Int. 2019 ;19:43. Epub 2019 Feb 28. PMID:
30858760
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Thyroid Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Epidermal growth factor receptor (EGFR) inhibitor
[+]
Epigallocatechin-3-gallate mitigates cyclophosphamide-induced intestinal injury by modulating the tight junctions, inflammation and dysbiosis.
Nov 14, 2021
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2021 Nov 15 ;12(22):11671-11685. Epub 2021 Nov 15. PMID:
34730149
Article Published Date
: Nov 14, 2021
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemoprotective Agents
,
Gastrointestinal Agents
,
Tumor Necrosis Factor (TNF) Alpha Enhancer
[+]
Epigallocatechin-3-gallate provides protection against Alzheimer's disease-induced learning and memory impairments.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Des Devel Ther. 2021 ;15:2013-2024. Epub 2021 May 13. PMID:
34012254
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Epigallocatechin-3-gallate reduces hepatic oxidative stress and lowers CYP-mediated bioactivation and toxicity of acetaminophen.
Aug 09, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2019 Aug 10 ;11(8). Epub 2019 Aug 10. PMID:
31405142
Article Published Date
: Aug 09, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Chemically-Induced Liver Damage
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
Problem Substances
:
Acetaminophen
[+]
Epigallocatechin-3-gallate suppresses neutrophil migration speed in a transgenic zebrafish model accompanied by reduced inflammatory mediators
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Inflamm Res. 2019 ;12:231-239. Epub 2019 Aug 29. PMID:
31695470
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Inflammation
,
Inflammation: Neutrophil-Mediated
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Epigallocatechin-3-gallate-loaded liposomes favour anti-inflammation of microglia cells and promote neuroprotection.
Mar 15, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2021 Mar 16 ;22(6). Epub 2021 Mar 16. PMID:
33809762
Article Published Date
: Mar 15, 2021
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Brain Inflammation
,
Neurodegenerative Diseases
,
Parkinson's Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
Epigallocatechin-3-O-gallate attenuated the endoglin expression and myocardial fibrosis in vitro and in vivo.
Jun 15, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cell Mol Med. 2016 Jun 16. Epub 2016 Jun 16. PMID:
27306149
Article Published Date
: Jun 15, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Myocardial Fibrosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
[+]
Epigallocatechin-3-O-gallate modulates the diversity of gut microbiota in ovariectomized rats.
Jan 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Food Sci Nutr. 2020 Feb ;8(2):1295-1302. Epub 2020 Jan 27. PMID:
32148835
Article Published Date
: Jan 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Anxiety
Pharmacological Actions
:
Anti-Anxiety Agents
,
Gastrointestinal Agents
[+]
Eriodictyol synergistically potentiates the anti-tumour effect of EGCG by amplifying 67LR-dependent signalling in MM cells
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2015 ;5:9474. Epub 2015 Mar 31. PMID:
25824377
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Eriodictyol
,
Yerba Santa
Diseases
:
Multiple Myeloma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Bioenhancer
,
EGCG Sensitizer
,
Natural Substance Synergy
[+]
ERα36 is an effective target of epigallocatechin-3-gallate in hepatocellular carcinoma.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Clin Exp Pathol. 2019 ;12(9):3222-3234. Epub 2019 Sep 1. PMID:
31934166
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
[+]
Ferulic acid enhances the vasorelaxant properties of EGCG in TNF-α-induced inflammatory aorta.
Jun 30, 2014
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2014 Jul ;25(7):807-14. Epub 2014 Apr 4. PMID:
24794014
Article Published Date
: Jun 30, 2014
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Ferulic acid
Diseases
:
Inflammation
Pharmacological Actions
:
Tumor Necrosis Factor (TNF) Alpha Inhibitor
,
Vasodilator Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Fructooligosaccharides increase in plasma concentration of (-)-epigallocatechin-3-gallate.
Dec 05, 2021
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2021 Dec 6. Epub 2021 Dec 6. PMID:
34870993
Article Published Date
: Dec 05, 2021
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
FOS (Fructooligosaccharides)
Additional Keywords
:
Increased Bioavailability
[+]
Green tea (-)-epigalocatechin-3-gallate induces cell death in gastrointestinal stromal tumor including imatinib-resistant cells.
Oct 01, 2009
Click here to read the entire abstract
Pubmed Data
: Cancer Biol Ther. 2009 Oct;8(20):1934-9. Epub 2009 Oct 22. PMID:
19770581
Article Published Date
: Oct 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cancers: Drug Resistant
,
Gastrointestinal Stromal Tumors
Pharmacological Actions
:
Apoptotic
[+]
Green tea and its active compound epigallocathechin-3-gallate (EGCG) inhibit neuronal apoptosis in a middle cerebral artery occlusion (MCAO) model.
Jun 24, 2021
Click here to read the entire abstract
Pubmed Data
: J Basic Clin Physiol Pharmacol. 2021 Jun 25 ;32(4):319-325. Epub 2021 Jun 25. PMID:
34214383
Article Published Date
: Jun 24, 2021
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions
:
Neuroprotective Agents
[+]
Green tea Catechin EGCG could prevent obesity-related precocious puberty through NKB/NK3R signaling pathway.
Jun 08, 2022
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2022 Jun 9:109085. Epub 2022 Jun 9. PMID:
35691596
Article Published Date
: Jun 08, 2022
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Obesity
,
Puberty: Precocious
Additional Keywords
:
Risk Reduction
[+]
Green tea catechins alleviate autoimmune symptoms and visual impairment in a murine model for human chronic intraocular inflammation.
Jan 18, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2019 02 19 ;9(1):2301. Epub 2019 Feb 19. PMID:
30783194
Article Published Date
: Jan 18, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Autoimmune Diseases
,
Uveitis
Pharmacological Actions
:
Immunomodulatory
,
Immunomodulatory: Th17 downregulation
[+]
Green tea epigallocatechin-3-gallate attenuates Porphyromonas gingivalis-induced atherosclerosis.
Jan 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pathog Dis. 2013 Feb ;67(1):76-83. Epub 2012 Nov 15. PMID:
23620122
Article Published Date
: Jan 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Atherosclerosis
,
Porphyromonas gingivalis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Heme oxygenase-1 up-regulation
,
MicroRNA modulator
Additional Keywords
:
Gene Expression Regulation
[+]
Green tea extract inhibits proliferation of uterine leiomyoma cells in vitro and in nude mice.
Jan 12, 2010
Click here to read the entire abstract
Pubmed Data
: Am J Obstet Gynecol. 2010 Jan 12. Epub 2010 Jan 12. PMID:
20074693
Article Published Date
: Jan 12, 2010
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Leiomyoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
[+]
Green tea extract rich in epigallocatechin gallate impairs alveolar bone loss.
Nov 30, 2020
Click here to read the entire abstract
Pubmed Data
: Int J Exp Pathol. 2020 Dec ;101(6):277-288. Epub 2020 Nov 11. PMID:
33174663
Article Published Date
: Nov 30, 2020
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Periodontal Diseases
[+]
Green tea extract rich in epigallocatechin-3-Gallate prevents fatty liver in mice fed a high-fat diet.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(11):e0141227. Epub 2015 Nov 4. PMID:
26536464
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Fatty Liver
,
High Fat Diet
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Plant Extracts
,
Risk Reduction
[+]
Green tea extracts reversed the striatal oxidative stress and immunohistochemistry alterations in rats.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2015 ;2015:161092. Epub 2015 Jun 18. PMID:
26167188
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Neurodegenerative Diseases
,
Oxidative Stress
,
Parkinson's Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Neuroprotective Agents
[+]
Green tea inhibits the genetic expression of hepatic enzymes associated with gluconeogenesis in vivo.
Aug 01, 2010
Click here to read the entire abstract
Pubmed Data
: South Med J. 2010 Aug;103(8):729-37. PMID:
15549673
Article Published Date
: Aug 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Diabetes Mellitus: Type 1
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Gluconeogenesis Inhibitor
[+]
Green tea polyphenol improves gut dysbiosis and serum bile acids dysregulation in high-fat diet model.
Jun 30, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Clin Biochem Nutr. 2019 Jul ;65(1):34-46. Epub 2019 Apr 6. PMID:
31379412
Article Published Date
: Jun 30, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Dysbiosis
,
High Fat Diet
Pharmacological Actions
:
Gastrointestinal Agents
[+]
Green tea polyphenols ameliorate the early renal damage induced by a high-fat diet.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2017 ;2017:9032792. Epub 2017 Jul 26. PMID:
28814987
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
High Fat Diet
,
Kidney Damage
Pharmacological Actions
:
Renoprotective
[+]
Green tea polyphenols reduce autoimmune symptoms in a mouse model for human Sjogren's syndrome.
Mar 01, 2007
Click here to read the entire abstract
Pubmed Data
: Autoimmunity. 2007 Mar;40(2):138-47. PMID:
17364504
Article Published Date
: Mar 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Sjogren's Syndrome
[+]
Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.
Dec 31, 2008
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2009 ;4(2):e4606. Epub 2009 Feb 26. PMID:
19242551
Article Published Date
: Dec 31, 2008
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Down Syndrome
Pharmacological Actions
:
Antioxidants
[+]
Green tea rescues mice from lethal endotoxemia and sepsis.
Nov 07, 2007
Click here to read the entire abstract
Pubmed Data
: PLoS One. 2007 Nov 7;2(11):e1153. PMID:
17987129
Article Published Date
: Nov 07, 2007
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Endotoxemia
,
Sepsis
[+]
Green Tea-EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: Am J Transl Res. 2009;1(1):72-9. Epub 2009 Jan 1. PMID:
19966940
Article Published Date
: Jan 01, 2009
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Pharmacological Actions
:
Neuroprotective Agents
[+]
Green teaGreen tea polyphenol administration partly ameliorates irinotecan chemotherapy-induced side effects in the small intestine of mice.
Mar 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2007 Mar;137(3):634-40. PMID:
17311952
Article Published Date
: Mar 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
,
Polyphenols
Diseases
:
Chemotherapy-Induced Toxicity: Irinotecan
Pharmacological Actions
:
Antineoplastic Agents
[+]
Induction of p21 by EGCG could provide clinically useful normalization of salivary glands by promoting differentiation and reducing PCNA levels.
Jan 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Inflamm Allergy Drug Targets. 2014 Feb ;13(1):15-24. PMID:
24329914
Article Published Date
: Jan 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Autoimmune Diseases
,
Diabetes Mellitus: Type 1: Prevention
,
Sjogren's Syndrome
Pharmacological Actions
:
Anticarcinogenic Agents
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Intra-tumoral injection of TriCurin significantly inhibited tumor growth by 85.5%.
Jul 15, 2016
Click here to read the entire abstract
Pubmed Data
: Oncotarget. 2016 Jul 16. Epub 2016 Jul 16. PMID:
27437871
Article Published Date
: Jul 15, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Resveratrol
Diseases
:
Head and Neck Cancer
,
Human Papillomavirus (HPV)
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Chemopreventive
,
Tumor Suppressor Protein p53 Upregulation
[+]
Mice receiving EGCG have a lower mortality rate and exhibit less inflammation and a better preserved cardiac function and telomere biology.
Jun 29, 2016
Click here to read the entire abstract
Pubmed Data
: J Cardiol. 2016 Jun 30. Epub 2016 Jun 30. PMID:
27374189
Article Published Date
: Jun 29, 2016
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cardiac Mortality
,
Heart Failure
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
,
Telomere Protective
Additional Keywords
:
Mortality
[+]
Mobile phone radiation-induced free radical damage in the liver is inhibited by the antioxidants n-acetyl cysteine and epigallocatechin-gallate.
Sep 01, 2010
Click here to read the entire abstract
Pubmed Data
: Int J Radiat Biol. 2010 Sep 1. Epub 2010 Sep 1. PMID:
20807176
Article Published Date
: Sep 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
NAC (N-acetyl-L-cysteine)
Diseases
:
Mobile Phone-Induced Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Obesity may increase susceptibility to chronic pain often due to poor diet.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Eur J Pain. 2018 08 ;22(7):1203-1213. Epub 2018 Mar 2. PMID:
29436058
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Ginseng
,
Resveratrol
,
Sulforaphane
Diseases
:
Chronic Pain
,
Inflammation
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Inflammatory Diet
,
Risk Factors
[+]
Oral consumption of the green tea polyphenol EGCG improves disease paramaters in a mouse model of human Sjogren's syndrome.
Oct 24, 2008
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2008 Oct 24;83(17-18):581-8. Epub 2008 Sep 6. PMID:
18809413
Article Published Date
: Oct 24, 2008
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Sjogren's Syndrome
[+]
Oral intake of green tea extract or its catechin constituents attenuates sodium iodate-induced retinal degeneration.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 ;6:29546. Epub 2016 Jul 7. PMID:
27383468
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Retinal Diseases
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
Orally administered EGCG attenuates injury to the retina caused by ischemia/reperfusion where caspases were activated.
Mar 10, 2008
Click here to read the entire abstract
Pubmed Data
: Brain Res. 2008 Mar 10 ;1198:141-52. Epub 2007 Dec 15. PMID:
18255049
Article Published Date
: Mar 10, 2008
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
Diseases
:
Glaucoma
,
Oxidative Stress
Pharmacological Actions
:
Neuroprotective Agents
,
Regenerative
[+]
Our results suggest that CucB and EGCG have unique properties and may be developed as potential biopesticides for aphid control in agriculture.
Jan 04, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Insects. 2021 Jan 5 ;12(1). Epub 2021 Jan 5. PMID:
33466501
Article Published Date
: Jan 04, 2021
Study Type
: Insect Study
Additional Links
Substances
:
Cucurbitacin B
,
EGCG (Epigallocatechin gallate)
Pharmacological Actions
:
Insecticidal
[+]
Paternal inheritance of bisphenol A cardiotoxic effects: The implications of sperm epigenome.
Feb 19, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2021 Feb 20 ;22(4). Epub 2021 Feb 20. PMID:
33672782
Article Published Date
: Feb 19, 2021
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Bisphenol Toxicity
,
Fetal Origin of Adult Disease
Pharmacological Actions
:
Cytoprotective
Additional Keywords
:
Transgenerational inheritance
Problem Substances
:
Bisphenol A
Adverse Pharmacological Actions
:
Cardiotoxic
[+]
Potential ameliorative effects of epigallocatechin-3-gallate against cigarette smoke exposure induced renal and hepatic deficits.
Jan 12, 2020
Click here to read the entire abstract
Pubmed Data
: Ecotoxicol Environ Saf. 2020 Jan 13 ;191:110202. Epub 2020 Jan 13. PMID:
31945511
Article Published Date
: Jan 12, 2020
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chemically-Induced Liver Damage
,
Kidney Damage: Chemically-Induced
,
Smoking
Pharmacological Actions
:
Hepatoprotective
,
Renoprotective
[+]
Potential role of green tea extract and epigallocatechin gallate in preventing bisphenol A-induced metabolic disorders.
Oct 31, 2021
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2021 Nov ;92:153754. Epub 2021 Sep 14. PMID:
34607205
