Elecampane

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5 Diseases Researched for Elecampane
NameACCKFocus
Hypoxia11Locked
MRSA11Locked
Mycobacterium Avium 11Locked
Mycoplasma Infections11Locked
Tumors11Locked
2 Pharmacological Actions Researched for Elecampane
NameACCKFocus
Anti-Bacterial Agents11Locked
Apoptotic11Locked

View the Evidence:
89 Abstracts with Elecampane Research

[+]

Igalan from Inula helenium (L.) suppresses the atopic dermatitis-like response in stimulated HaCaT keratinocytes.Feb 29, 2020

Pubmed Data : Inflamm Res. 2020 Mar ;69(3):309-319. Epub 2020 Jan 30. PMID: 32002586
Article Published Date : Feb 29, 2020
Study Type : Human In Vitro
Additional Links
Substances : Elecampane
Diseases : Atopic Dermatitis, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation
Additional Keywords : Plant Extracts
[+]

Activation of PXR by alantolactone ameliorates DSS-induced experimental colitis.Jan 11, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 11 12 ;9(1):16636. Epub 2019 Nov 12. PMID: 31719637
Article Published Date : Jan 11, 2019
Study Type : Animal Study
Additional Links
Substances : Elecampane
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Alantolactone alleviates collagen-induced arthritis and inhibits Th17 cell differentiation through modulation of STAT3 signalling.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2021 Dec ;59(1):134-145. PMID: 33556301
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Elecampane
Diseases : Arthritis, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Alantolactone and isoalantolactone prevent amyloid β 25-35 -induced toxicity.Apr 30, 2017

Pubmed Data : Phytother Res. 2017 May ;31(5):801-811. Epub 2017 Mar 21. PMID: 28326625
Article Published Date : Apr 30, 2017
Study Type : Animal Study
Additional Links
Substances : Elecampane
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Alantolactone exhibits antiproliferative and apoptosis-promoting properties in colon cancer modelAug 29, 2021

Pubmed Data : Mol Cell Biochem. 2021 Aug 30. Epub 2021 Aug 30. PMID: 34460036
Article Published Date : Aug 29, 2021
Study Type : Animal Study
Additional Links
Substances : Elecampane
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Alantolactone promotes ER stress-mediated apoptosis by inhibition of TrxR1 in triple-negative breast cancer cell lines.Dec 31, 2018

Pubmed Data : J Cell Mol Med. 2019 03 ;23(3):2194-2206. Epub 2019 Jan 4. PMID: 30609207
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic
[+]

Alantolactone suppresses proliferation and the inflammatory response in human HaCaT keratinocytes.Jun 24, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Life (Basel). 2021 Jun 25 ;11(7). Epub 2021 Jun 25. PMID: 34202301
Article Published Date : Jun 24, 2021
Study Type : Animal Study
Additional Links
Substances : Elecampane
Diseases : Psoriasis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-23 Downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Anti-neuroinflammatory effect of alantolactone through the suppression of the NF-κB and MAPK signaling pathways.Jan 17, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2019 07 18 ;8(7). Epub 2019 Jul 18. PMID: 31323885
Article Published Date : Jan 17, 2019
Study Type : Animal Study
Additional Links
Substances : Elecampane
Diseases : Brain Inflammation , Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor
[+]

Efficacy of methanol-water extract of Inula helenium root against oxidative DNA damage.Dec 31, 2020

Pubmed Data : J Tradit Chin Med. 2021 04 ;41(2):293-300. PMID: 33825410
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Elecampane
Diseases : DNA damage, Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Isoalantolactone increases the sensitivity of prostate cancer cells to cisplatin treatment.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Dev Biol. 2021 ;9:632779. Epub 2021 Apr 20. PMID: 33959604
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Prostate Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Isoalantolactone is a potential therapeutic reagent against inflammation and acute lung injury.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharmacol Sin. 2019 Jan ;40(1):64-74. Epub 2018 Jul 16. PMID: 30013035
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Elecampane
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Lung Damage
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Total sesquiterpene lactones isolated from Inula helenium L. attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions.Jul 14, 2018

Pubmed Data : Phytomedicine. 2018 Jul 15 ;46:78-84. Epub 2018 Apr 19. PMID: 30097125
Article Published Date : Jul 14, 2018
Study Type : Animal Study
Additional Links
Substances : Elecampane
Diseases : Atopic Dermatitis
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Isoalantolactone inhibits UM-SCC-10A cell growth via cell cycle arrest and apoptosis induction Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(9):e76000. Epub 2013 Sep 30. PMID: 24098753
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Head and Neck Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

A comprehensive review of anticancer mechanisms of action of Alantolactone.Mar 31, 2021

Pubmed Data : Biomed Pharmacother. 2021 Apr ;136:111231. Epub 2021 Jan 14. PMID: 33454597
Article Published Date : Mar 31, 2021
Study Type : Review
Additional Links
Substances : Elecampane
Diseases : Cancers: All
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

Activation of Nrf2 by costunolide provides neuroprotective effect in PC12 cells.Jul 16, 2019

Pubmed Data : Food Funct. 2019 Jul 17 ;10(7):4143-4152. PMID: 31241085
Article Published Date : Jul 16, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Active ingredients of Inula helenium L. exhibits similar anti-cancer effects as isoalantolactone in pancreatic cancer cells.Aug 31, 2020

Pubmed Data : Nat Prod Res. 2020 Sep ;34(17):2539-2544. Epub 2019 Jan 19. PMID: 30661396
Article Published Date : Aug 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Natural Substances Versus Drugs, Plant Extracts
[+]

Alantolactone can be a promising candidate for the treatment of inflammation-associated glucose intolerance and insulin resistance.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2017 ;8:405. Epub 2017 Jun 29. PMID: 28706484
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Inflammation, Insulin Resistance
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation
[+]

Alantolactone enhances gemcitabine sensitivity of lung cancer cells.Aug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2019 Sep ;44(3):1026-1038. Epub 2019 Jul 8. PMID: 31524219
Article Published Date : Aug 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cancers: Drug Resistant, Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Alantolactone enhances the phagocytic properties of human macrophages and modulates their proinflammatory functions.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:1339. Epub 2020 Sep 3. PMID: 33013371
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Immunomodulatory, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Transforming growth factor beta (TGF-β) upregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Alantolactone exhibited anti-herpes simplex virus 1 (HSV-1) action in vitro.Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Trends. 2015 Dec ;9(6):420-2. PMID: 26781801
Article Published Date : Nov 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Herpes Simplex Virus Type 1
Pharmacological Actions : Antiviral Agents
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Alantolactone exhibits selective antitumor effects in HELA human cervical cancer cells.Oct 31, 2019

Pubmed Data : J BUON. 2019 Nov-Dec;24(6):2310-2315. PMID: 31983099
Article Published Date : Oct 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cervical Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest, NF-kappaB Inhibitor
Additional Keywords : Selective Antiproliferation
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Alantolactone has potential to be used for the treatment of liver cancer.Nov 30, 2019

Pubmed Data : Artif Cells Nanomed Biotechnol. 2019 Dec ;47(1):1961-1970. PMID: 31116036
Article Published Date : Nov 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
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Alantolactone induces activation of apoptosis in human hepatoma cells.Aug 31, 2012

Pubmed Data : Food Chem Toxicol. 2012 Sep ;50(9):3313-9. Epub 2012 Jun 18. PMID: 22721982
Article Published Date : Aug 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation
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Alantolactone induces apoptosis and improves chemosensitivity of pancreatic cancer cells.Dec 31, 2017

Pubmed Data : Toxicol Appl Pharmacol. 2018 10 1 ;356:159-171. Epub 2018 Aug 4. PMID: 30086361
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Pancreatic Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Oxaliplatin
[+]

Alantolactone induces apoptosis and suppresses migration in MCF‑7 human breast cancer cells.Sep 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2018 Oct ;42(4):1847-1856. Epub 2018 Jul 4. PMID: 30015828
Article Published Date : Sep 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor
[+]

Alantolactone induces apoptosis in chronic myelogenous leukemia sensitive or resistant to imatinib.Aug 31, 2013

Pubmed Data : Apoptosis. 2013 Sep ;18(9):1060-70. PMID: 23613107
Article Published Date : Aug 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction.Aug 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : IUBMB Life. 2012 Sep ;64(9):783-94. Epub 2012 Jul 27. PMID: 22837216
Article Published Date : Aug 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Glioblastoma
Pharmacological Actions : Antineoplastic Agents, Antioxidants, Antiproliferative , Apoptotic, NF-kappaB Inhibitor
[+]

Alantolactone induces apoptosis in THP-1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway.Dec 31, 2020

Pubmed Data : Chem Biol Drug Des. 2021 02 ;97(2):266-272. Epub 2020 Sep 5. PMID: 32780548
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Leukemia: Monocytic
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Alantolactone induces apoptosis of human cervical cancer cells.May 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2016 Jun ;11(6):4203-4207. Epub 2016 Apr 28. PMID: 27313767
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cervical Cancer
Pharmacological Actions : Bcl-2 protein down-regulation
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Alantolactone induces G1 phase arrest and apoptosis of multiple myeloma cells and overcomes bortezomib resistance.Jul 31, 2015

Pubmed Data : Apoptosis. 2015 Aug ;20(8):1122-33. PMID: 26033479
Article Published Date : Jul 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Multiple Myeloma
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Alantolactone induces gastric cancer BGC-823 cell apoptosis.May 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2019 Jun ;17(6):4795-4802. Epub 2019 Mar 19. PMID: 31186685
Article Published Date : May 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic
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Alantolactone inhibits breast cancer growth by antiangiogenic activity via blocking VEGFR2 signaling.Mar 31, 2018

Pubmed Data : Phytother Res. 2018 Apr ;32(4):643-650. Epub 2017 Dec 6. PMID: 29210118
Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Breast Cancer
Pharmacological Actions : Anti-Angiogenic
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Alantolactone inhibits cell autophagy and promotes apoptosis via AP2M1 in acute lymphoblastic leukemia.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2020 ;20:442. Epub 2020 Sep 9. PMID: 32943990
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Acute lymphoblastic leukemia (ALL)
Pharmacological Actions : Apoptotic, Autophagy Inhibitors
[+]

Alantolactone inhibits cervical cancer progression by downregulating BMI1.Jan 28, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2021 04 29 ;11(1):9251. Epub 2021 Apr 29. PMID: 33927214
Article Published Date : Jan 28, 2021
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative
[+]

Alantolactone inhibits stem-like cell phenotype, chemoresistance and metastasis in PC3 cells.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Res Pharm Sci. 2020 Dec ;15(6):551-562. Epub 2020 Nov 27. PMID: 33828598
Article Published Date : Nov 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Prostate Cancer
Pharmacological Actions : Anti-metastatic, Tumor Suppressor Protein p53 Upregulation
[+]

Alantolactone may provide a useful therapeutic approach for inflammation-associated diseases. Nov 30, 2012

Pubmed Data : Int Immunopharmacol. 2012 Dec ;14(4):375-83. Epub 2012 Aug 28. PMID: 22940184
Article Published Date : Nov 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Alantolactone mitigates renal injury induced by diabetes.Mar 31, 2020

Pubmed Data : Immunopharmacol Immunotoxicol. 2020 Apr ;42(2):84-92. Epub 2020 Feb 16. PMID: 32064988
Article Published Date : Mar 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Renoprotective
[+]

Alantolactone plays neuroprotective roles in traumatic brain injury.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2018 ;10(2):368-380. Epub 2018 Feb 15. PMID: 29511431
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Brain Injury: Traumatic
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, NF-kappaB Inhibitor
[+]

Alantolactone selectively ablates acute myeloid leukemia stem and progenitor cells.Sep 21, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Hematol Oncol. 2016 Sep 22 ;9(1):93. Epub 2016 Sep 22. PMID: 27658462
Article Published Date : Sep 21, 2016
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Acute Myeloid Leukemia
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Cancer Stem Cells
[+]

Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells.Jan 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Lett. 2015 Feb 1 ;357(1):393-403. Epub 2014 Nov 27. PMID: 25434800
Article Published Date : Jan 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative , STAT3 Inhibitor
[+]

Alantolactone sensitizes human pancreatic cancer cells to EGFR inhibitors through the inhibition of STAT3 signaling.Dec 31, 2018

Pubmed Data : Mol Carcinog. 2019 04 ;58(4):565-576. Epub 2019 Jan 4. PMID: 30520143
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cancers: Drug Resistant, Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, STAT3 Inhibitor
[+]

Alantolactone suppresses human osteosarcoma through the PI3K/AKT signaling pathway.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2020 02 ;21(2):675-684. Epub 2019 Dec 13. PMID: 31974628
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells.Apr 21, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Respir Res. 2020 Apr 22 ;21(1):95. Epub 2020 Apr 22. PMID: 32321531
Article Published Date : Apr 21, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Lung Injury: Smoke-Induced, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Apoptotic, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Alantolactone suppresses the metastatic phenotype and induces the apoptosis of glioblastoma cells.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2021 05 ;47(5). Epub 2021 Mar 2. PMID: 33649781
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Glioblastoma
Pharmacological Actions : Anti-metastatic, Apoptotic
[+]

Alantolactone, a natural sesquiterpene lactone, has potent antitumor activity against glioblastoma.Jan 11, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2017 07 12 ;36(1):93. Epub 2017 Jul 12. PMID: 28701209
Article Published Date : Jan 11, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Glioblastoma
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Antioxidant and anticancer activities of extract of Inula helenium (L.) in human U-87 MG glioblastoma cell line.Mar 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer Res Ther. 2018 Apr-Jun;14(3):658-661. PMID: 29893335
Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Glioblastoma
Pharmacological Actions : Antioxidants, Antiproliferative
Additional Keywords : Plant Extracts
[+]

Antiproliferative sesquiterpene lactones from the roots of Inula helenium.Sep 30, 2002

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2002 Oct ;25(10):1370-2. PMID: 12392098
Article Published Date : Sep 30, 2002
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cervical Cancer, Melanoma
Pharmacological Actions : Antiproliferative
Additional Keywords : Plant Extracts
[+]

Antitumor activity of alantolactone in lung cancer cell lines NCI-H1299 and Anip973.Dec 31, 2018

Pubmed Data : J Food Biochem. 2019 09 ;43(9):e12972. Epub 2019 Jul 5. PMID: 31489665
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Lung Cancer
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix Metalloproteinase-7 (MMP-7) Inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Antitumour activities of sesquiterpene lactones from Inula helenium and Inula japonica.Jun 30, 2012

Pubmed Data : Z Naturforsch C J Biosci. 2012 Jul-Aug;67(7-8):375-80. PMID: 23016276
Article Published Date : Jun 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative
[+]

Apoptosis induction by alantolactone in breast cancer MDA-MB-231 cells.Feb 28, 2018

Pubmed Data : Arch Pharm Res. 2018 Mar ;41(3):299-313. Epub 2017 Dec 6. PMID: 29214600
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
[+]

Dual targeting EGFR and STAT3 with erlotinib and alantolactone co-loaded PLGA nanoparticles for pancreatic cancer treatment.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:625084. Epub 2021 Mar 19. PMID: 33815107
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Pancreatic Cancer
Pharmacological Actions : Apoptotic, STAT3 Inhibitor
[+]

Elecampane (Inula helenium) extracts exhibit highly selective cytotoxicity against tumor cell lines. May 01, 2010

Pubmed Data : Complement Ther Clin Pract. 2010 May;16(2):81-5. Epub 2009 Aug 19. PMID: 16912983
Article Published Date : May 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Tumors
Pharmacological Actions : Apoptotic
Additional Keywords : Plant Extracts, Selective Cytotoxicity
[+]

Elecampane (Inula helenium) extracts may have a therapeutic role in hypoxia. Apr 01, 2005

Pubmed Data : Bull Exp Biol Med. 2005 Apr;139(4):414-7. PMID: 16027868
Article Published Date : Apr 01, 2005
Study Type : Commentary
Additional Links
Substances : Elecampane
Diseases : Hypoxia
Additional Keywords : Plant Extracts
[+]

Elecampane (Inula helenium) has potent antisaphylococcal activity, including against MRSA, in vitro. Jan 01, 2009

Pubmed Data : Br J Biomed Sci. 2009;66(4):186-9. PMID: 20095126
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : MRSA
Pharmacological Actions : Anti-Bacterial Agents
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Elecampane contains compounds with significant activity against Mycobacterium tubercolosis.May 01, 1999

Pubmed Data : Planta Med. 1999 May;65(4):351-5. PMID: 10364842
Article Published Date : May 01, 1999
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Mycobacterium Avium , Mycoplasma Infections
[+]

Enhancement of oxaliplatin-induced colon cancer cell apoptosis by alantolactone, a natural product inducer of ROS.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Sci. 2019 ;15(8):1676-1684. Epub 2019 Jun 4. PMID: 31360110
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Colon Cancer, Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Oxaliplatin
[+]

Ethanol extract of Inula helenium has anti-inflammatory effect via the induction of p38 MAPK-dependent HO-1 signaling pathway.Apr 30, 2013

Pubmed Data : Food Chem Toxicol. 2013 May ;55:386-95. Epub 2013 Jan 5. PMID: 23298677
Article Published Date : Apr 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Alcohol Toxicity , Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Ethyl acetate extract from Inula helenium L. inhibits the proliferation of pancreatic cancer cells by regulating the STAT3/AKT pathway.Mar 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2018 Apr ;17(4):5440-5448. Epub 2018 Feb 1. PMID: 29393456
Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Plant Extracts
[+]

Induction of ROS Overload by Alantolactone prompts oxidative DNA damage and apoptosis in colorectal cancer cells.Apr 13, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 Apr 14 ;17(4):558. Epub 2016 Apr 14. PMID: 27089328
Article Published Date : Apr 13, 2016
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic
[+]

Inhibition of growth of esophageal cancer by alantolactone.Jan 11, 2021

Pubmed Data : Anticancer Agents Med Chem. 2021 Jan 12. Epub 2021 Jan 12. PMID: 33438562
Article Published Date : Jan 11, 2021
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Esophageal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Wnt/β-catenin signaling pathway modulation
[+]

Inula L. secondary metabolites against oxidative stress-related human diseases.May 05, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 May 6 ;8(5). Epub 2019 May 6. PMID: 31064136
Article Published Date : May 05, 2019
Study Type : Review
Additional Links
Substances : Elecampane
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Isoalantolactone alleviates ovalbumin‑induced asthmatic inflammation.Sep 30, 2021

Pubmed Data : Mol Med Rep. 2021 Oct ;24(4). Epub 2021 Aug 9. PMID: 34368878
Article Published Date : Sep 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Asthma, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Isoalantolactone enhances the antimicrobial activity of penicillin G against Staphylococcus aureus.Feb 25, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pathogens. 2020 Feb 26 ;9(3). Epub 2020 Feb 26. PMID: 32110983
Article Published Date : Feb 25, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Antimicrobial
Additional Keywords : Natural Substance/Drug Synergy
[+]

Isoalantolactone enhances the radiosensitivity of UMSCC-10A cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(12):e0145790. Epub 2015 Dec 30. PMID: 26716456
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Radiosensitizer
[+]

Isoalantolactone from Inula helenium caused Nrf2-mediated induction of detoxifying enzymes.Sep 30, 2009

Pubmed Data : J Med Food. 2009 Oct ;12(5):1038-45. PMID: 19857067
Article Published Date : Sep 30, 2009
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Liver Cancer
Pharmacological Actions : Antioxidants, Chemopreventive, Detoxifier, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Isoalantolactone induces apoptosis in human breast cancer cells via ROS-mediated mitochondrial pathway and downregulation of SIRT1.Sep 30, 2016

Pubmed Data : Arch Pharm Res. 2016 Oct ;39(10):1441-1453. Epub 2016 Sep 6. PMID: 27600429
Article Published Date : Sep 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
[+]

Isoalantolactone induces apoptosis through reactive oxygen species-dependent upregulation of death receptor 5 in human esophageal cancer cells.Dec 31, 2017

Pubmed Data : Toxicol Appl Pharmacol. 2018 08 1 ;352:46-58. Epub 2018 May 22. PMID: 29800641
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Esophageal Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic
[+]

Isoalantolactone induces apoptosis through ROS-mediated ER stress and inhibition of STAT3 in prostate cancer cells.Dec 11, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2018 Dec 12 ;37(1):309. Epub 2018 Dec 12. PMID: 30541589
Article Published Date : Dec 11, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, STAT3 Inhibitor
[+]

Isoalantolactone induces autophagic cell death in SKOV3 human ovarian carcinoma cells via upregulation of PEA-15.Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2016 Feb ;35(2):833-40. Epub 2015 Nov 26. PMID: 26718904
Article Published Date : Jan 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative
[+]

Isoalantolactone induces intrinsic apoptosis through p53 signaling pathway in human lung squamous carcinoma cells.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(8):e0181731. Epub 2017 Aug 4. PMID: 28777796
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer, Squamous cell carcinoma
Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Sci. 2012 ;8(4):533-47. Epub 2012 Mar 28. PMID: 22532787
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Isoalantolactone inhibits esophageal squamous cell carcinoma growth.Dec 31, 2017

Pubmed Data : Dig Dis Sci. 2018 09 ;63(9):2285-2293. Epub 2018 May 21. PMID: 29781054
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Esophageal Cancer, Squamous cell carcinoma
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, MicroRNA modulator
[+]

Isoalantolactone inhibits LPS-induced inflammation via NF-κB inactivation in peritoneal macrophages and improves survival in sepsis.May 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Jun ;90:598-607. Epub 2017 Apr 11. PMID: 28407580
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Isoalantolactone inhibits pancreatic cancer proliferation by regulation of PI3K and Wnt signal pathway.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2021 ;16(3):e0247752. Epub 2021 Mar 4. PMID: 33661942
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin signaling pathway modulation
[+]

Isoalantolactone inhibits the migration and invasion of human breast cancer MDA-MB-231 cells.Aug 31, 2016

Pubmed Data : Oncol Rep. 2016 Sep ;36(3):1269-76. Epub 2016 Jul 20. PMID: 27461575
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Breast Cancer, Breast Cancer: Triple Negative , Cancer Metastasis
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
[+]

Isoalantolactone protects against Staphylococcus aureus pneumonia.Oct 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : FEMS Microbiol Lett. 2011 Nov ;324(2):147-55. Epub 2011 Sep 15. PMID: 22092816
Article Published Date : Oct 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Pneumonia, Staphylococcus aureus infection
Pharmacological Actions : Antimicrobial
Additional Keywords : Plant Extracts
[+]

Isoalantolactone protects LPS-induced acute lung injury through Nrf2 activation.Sep 30, 2018

Pubmed Data : Microb Pathog. 2018 Oct ;123:213-218. Epub 2018 Jul 19. PMID: 30009971
Article Published Date : Sep 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Isoalantolactone restores the sensitivity of gram-negative Enterobacteriaceae carrying MCR-1 to carbapenems.Dec 31, 2019

Pubmed Data : J Cell Mol Med. 2020 02 ;24(4):2475-2483. Epub 2020 Jan 19. PMID: 31957212
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Klebsiella Infections
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Isoalantolactone significantly inhibits K562/A02 cell proliferation mainly via caspase-dependent apoptotic pathway.Jan 31, 2017

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Feb ;25(1):110-114. PMID: 28245385
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
[+]

Nrf2-mediated induction of detoxifying enzymes by alantolactone present in Inula helenium.Oct 31, 2008

Pubmed Data : Phytother Res. 2008 Nov ;22(11):1500-5. PMID: 18702092
Article Published Date : Oct 31, 2008
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Oxidative Stress
Pharmacological Actions : Detoxifier, Enzyme Activators, Nrf2 activation, Phase II Detoxification Enzyme Inducer
Additional Keywords : Plant Extracts
[+]

Protective effect of total phenolic compounds from Inula helenium on hydrogen peroxide-induced oxidative stress in SH-SY5Y cells.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Indian J Pharm Sci. 2015 Mar-Apr;77(2):163-9. PMID: 26009648
Article Published Date : Feb 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Sesquiterpenoids from the roots of Inula helenium inhibit acute myelogenous leukemia progenitor cells.Dec 31, 2018

Pubmed Data : Bioorg Chem. 2019 05 ;86:363-367. Epub 2019 Jan 31. PMID: 30753990
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Plant Extracts
[+]

Sesquiterpenoids isolated from the flower of Inula japonica as potential antitumor leads for intervention of paclitaxel-resistant non-small-cell lung cancer.Dec 31, 2019

Pubmed Data : Bioorg Chem. 2020 08 ;101:103973. Epub 2020 May 24. PMID: 32521367
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antiproliferative , Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Targeting non-oncogene ROS pathway by alantolactone in B cell acute lymphoblastic leukemia cells.Jun 14, 2019

Pubmed Data : Life Sci. 2019 Jun 15 ;227:153-165. Epub 2019 Apr 17. PMID: 31004657
Article Published Date : Jun 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Acute lymphoblastic leukemia (ALL)
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

These findings provide an in-depth insight into the molecular mechanism of alantolactone in the treatment of lung cancer.Jan 23, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 07 24 ;7(1):6242. Epub 2017 Jul 24. PMID: 28740138
Article Published Date : Jan 23, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cancers: Drug Resistant, Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

These findings provide the potential of I. helenium as a promising phytomedicine for the treatment and prevention of triple-negative breast cancer.Nov 30, 2018

Pubmed Data : Phytother Res. 2018 Dec ;32(12):2501-2509. Epub 2018 Sep 24. PMID: 30251272
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic
Additional Keywords : Plant Extracts
[+]

Total sesquiterpene lactones prepared from Inula helenium L. has potentials in prevention and therapy of rheumatoid arthritis.Jan 19, 2017

Pubmed Data : J Ethnopharmacol. 2017 Jan 20 ;196:39-46. Epub 2016 Dec 15. PMID: 27988396
Article Published Date : Jan 19, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Arthritis, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Elecampane has an ancient history of medicinal use.Jan 01, 1998

Pubmed Data : Bull Indian Inst Hist Med Hyderabad. 1998 Jan;28(1):7-11. PMID: 12587579
Article Published Date : Jan 01, 1998
Additional Links
Substances : Elecampane
[+]

Elecampane induces detoxifying enzymes and may hold promise as a chemopreventive agent.Sep 01, 2007

Pubmed Data : J Med Food. 2007 Sep;10(3):503-10. PMID: 17887945
Article Published Date : Sep 01, 2007
Additional Links
Substances : Elecampane

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