Elecampane

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58 Diseases Researched for Elecampane
NameACCKFocus
Inflammation813Locked
Atopic Dermatitis27Locked
Oxidative Stress67Locked
Pancreatic Cancer77Locked
Breast Cancer66Locked
Lipopolysaccharide-Induced Toxicity56Locked
Lung Cancer66Locked
Breast Cancer: Triple Negative 45Locked
Cancers: Drug Resistant44Locked
Cervical Cancer44Locked
Glioblastoma44Locked
Prostate Cancer34Locked
Squamous cell carcinoma44Locked
Arthritis23Locked
Colon Cancer23Locked
Esophageal Cancer33Locked
Liver Cancer33Locked
Rheumatoid Arthritis23Locked
Staphylococcus aureus infection33Locked
Acute lymphoblastic leukemia (ALL)22Locked
Alzheimer's Disease12Locked
Brain Inflammation 12Locked
Carcinoma: Non-Small-Cell Lung22Locked
Colitis12Locked
Colorectal Cancer22Locked
DNA damage12Locked
Leukemia: Acute myelogenous leukemia (AML) 22Locked
Lung Damage12Locked
Middle Cerebral Artery Occlusion (MCAO)12Locked
Psoriasis12Locked
Acute Myeloid Leukemia11Locked
Alcohol Toxicity 11Locked
Asthma11Locked
Brain Injury: Traumatic11Locked
Cancer Metastasis11Locked
Cancers: All11Locked
Diabetic Nephropathy11Locked
Gastric Cancer11Locked
Head and Neck Cancer11Locked
Herpes Simplex Virus Type 111Locked
Hydrogen Peroxide Induced Toxicity11Locked
Hypoxia11Locked
Insulin Resistance11Locked
Klebsiella Infections11Locked
Leukemia: Chronic myelogenous leukemia (CML) 11Locked
Leukemia: Monocytic11Locked
Lung Injury: Acute11Locked
Lung Injury: Smoke-Induced11Locked
MRSA11Locked
Melanoma11Locked
Multiple Myeloma11Locked
Mycobacterium Avium 11Locked
Mycoplasma Infections11Locked
Osteosarcoma11Locked
Ovarian Cancer11Locked
Pneumonia11Locked
Sepsis11Locked
Tumors11Locked
45 Pharmacological Actions Researched for Elecampane
NameACCKFocus
Apoptotic4143Locked
Antiproliferative 3233Locked
Anti-Inflammatory Agents1929Locked
NF-kappaB Inhibitor1619Locked
Antioxidants1116Locked
Nrf2 activation59Locked
Anti-metastatic88Locked
Antineoplastic Agents88Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor68Locked
Cell cycle arrest66Locked
Chemosensitizer56Locked
Neuroprotective Agents46Locked
Cyclooxygenase 2 Inhibitors55Locked
Interleukin-6 Downregulation45Locked
Interleukin-1 beta downregulation34Locked
STAT3 Inhibitor44Locked
Tumor Suppressor Protein p53 Upregulation44Locked
Anti-Bacterial Agents33Locked
Interleukin-8 downregulation23Locked
Antimicrobial22Locked
Bcl-2 protein down-regulation22Locked
Detoxifier22Locked
Heme oxygenase-1 up-regulation22Locked
Interferon Gamma Reducer12Locked
Interleukin-17 downregulation12Locked
Interleukin-23 Downregulation12Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor22Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor22Locked
Wnt/β-catenin signaling pathway modulation22Locked
Anti-Angiogenic11Locked
Anti-Apoptotic11Locked
Antiviral Agents11Locked
Autophagy Inhibitors11Locked
Chemopreventive11Locked
Enzyme Activators11Locked
Immunomodulatory11Locked
Interleukin-10 upregulation11Locked
Matrix Metalloproteinase-7 (MMP-7) Inhibitor11Locked
MicroRNA modulator11Locked
Nitric Oxide Inhibitor11Locked
Phase II Detoxification Enzyme Inducer11Locked
Postaglandin PGE2 downregulation 11Locked
Radiosensitizer11Locked
Renoprotective11Locked
Transforming growth factor beta (TGF-β) upregulation11Locked

View the Evidence:
89 Abstracts with Elecampane Research

[+]

Igalan from Inula helenium (L.) suppresses the atopic dermatitis-like response in stimulated HaCaT keratinocytes.Feb 29, 2020

Pubmed Data : Inflamm Res. 2020 Mar ;69(3):309-319. Epub 2020 Jan 30. PMID: 32002586
Article Published Date : Feb 29, 2020
Study Type : Human In Vitro
Additional Links
Substances : Elecampane
Diseases : Atopic Dermatitis, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation
Additional Keywords : Plant Extracts
[+]

Activation of PXR by alantolactone ameliorates DSS-induced experimental colitis.Jan 11, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 11 12 ;9(1):16636. Epub 2019 Nov 12. PMID: 31719637
Article Published Date : Jan 11, 2019
Study Type : Animal Study
Additional Links
Substances : Elecampane
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Alantolactone alleviates collagen-induced arthritis and inhibits Th17 cell differentiation through modulation of STAT3 signalling.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2021 Dec ;59(1):134-145. PMID: 33556301
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Elecampane
Diseases : Arthritis, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Alantolactone and isoalantolactone prevent amyloid β 25-35 -induced toxicity.Apr 30, 2017

Pubmed Data : Phytother Res. 2017 May ;31(5):801-811. Epub 2017 Mar 21. PMID: 28326625
Article Published Date : Apr 30, 2017
Study Type : Animal Study
Additional Links
Substances : Elecampane
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Alantolactone exhibits antiproliferative and apoptosis-promoting properties in colon cancer modelAug 29, 2021

Pubmed Data : Mol Cell Biochem. 2021 Aug 30. Epub 2021 Aug 30. PMID: 34460036
Article Published Date : Aug 29, 2021
Study Type : Animal Study
Additional Links
Substances : Elecampane
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Alantolactone promotes ER stress-mediated apoptosis by inhibition of TrxR1 in triple-negative breast cancer cell lines.Dec 31, 2018

Pubmed Data : J Cell Mol Med. 2019 03 ;23(3):2194-2206. Epub 2019 Jan 4. PMID: 30609207
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic
[+]

Alantolactone suppresses proliferation and the inflammatory response in human HaCaT keratinocytes.Jun 24, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Life (Basel). 2021 Jun 25 ;11(7). Epub 2021 Jun 25. PMID: 34202301
Article Published Date : Jun 24, 2021
Study Type : Animal Study
Additional Links
Substances : Elecampane
Diseases : Psoriasis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-23 Downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Anti-neuroinflammatory effect of alantolactone through the suppression of the NF-κB and MAPK signaling pathways.Jan 17, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2019 07 18 ;8(7). Epub 2019 Jul 18. PMID: 31323885
Article Published Date : Jan 17, 2019
Study Type : Animal Study
Additional Links
Substances : Elecampane
Diseases : Brain Inflammation , Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor
[+]

Efficacy of methanol-water extract of Inula helenium root against oxidative DNA damage.Dec 31, 2020

Pubmed Data : J Tradit Chin Med. 2021 04 ;41(2):293-300. PMID: 33825410
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Elecampane
Diseases : DNA damage, Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Isoalantolactone increases the sensitivity of prostate cancer cells to cisplatin treatment.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Dev Biol. 2021 ;9:632779. Epub 2021 Apr 20. PMID: 33959604
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Prostate Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Isoalantolactone is a potential therapeutic reagent against inflammation and acute lung injury.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharmacol Sin. 2019 Jan ;40(1):64-74. Epub 2018 Jul 16. PMID: 30013035
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Elecampane
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Lung Damage
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Total sesquiterpene lactones isolated from Inula helenium L. attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions.Jul 14, 2018

Pubmed Data : Phytomedicine. 2018 Jul 15 ;46:78-84. Epub 2018 Apr 19. PMID: 30097125
Article Published Date : Jul 14, 2018
Study Type : Animal Study
Additional Links
Substances : Elecampane
Diseases : Atopic Dermatitis
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Isoalantolactone inhibits UM-SCC-10A cell growth via cell cycle arrest and apoptosis induction Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(9):e76000. Epub 2013 Sep 30. PMID: 24098753
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Head and Neck Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

A comprehensive review of anticancer mechanisms of action of Alantolactone.Mar 31, 2021

Pubmed Data : Biomed Pharmacother. 2021 Apr ;136:111231. Epub 2021 Jan 14. PMID: 33454597
Article Published Date : Mar 31, 2021
Study Type : Review
Additional Links
Substances : Elecampane
Diseases : Cancers: All
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

Activation of Nrf2 by costunolide provides neuroprotective effect in PC12 cells.Jul 16, 2019

Pubmed Data : Food Funct. 2019 Jul 17 ;10(7):4143-4152. PMID: 31241085
Article Published Date : Jul 16, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Active ingredients of Inula helenium L. exhibits similar anti-cancer effects as isoalantolactone in pancreatic cancer cells.Aug 31, 2020

Pubmed Data : Nat Prod Res. 2020 Sep ;34(17):2539-2544. Epub 2019 Jan 19. PMID: 30661396
Article Published Date : Aug 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Natural Substances Versus Drugs, Plant Extracts
[+]

Alantolactone can be a promising candidate for the treatment of inflammation-associated glucose intolerance and insulin resistance.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2017 ;8:405. Epub 2017 Jun 29. PMID: 28706484
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Inflammation, Insulin Resistance
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation
[+]

Alantolactone enhances gemcitabine sensitivity of lung cancer cells.Aug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2019 Sep ;44(3):1026-1038. Epub 2019 Jul 8. PMID: 31524219
Article Published Date : Aug 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cancers: Drug Resistant, Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Alantolactone enhances the phagocytic properties of human macrophages and modulates their proinflammatory functions.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:1339. Epub 2020 Sep 3. PMID: 33013371
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Immunomodulatory, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Transforming growth factor beta (TGF-β) upregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Alantolactone exhibited anti-herpes simplex virus 1 (HSV-1) action in vitro.Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Trends. 2015 Dec ;9(6):420-2. PMID: 26781801
Article Published Date : Nov 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Herpes Simplex Virus Type 1
Pharmacological Actions : Antiviral Agents
[+]

Alantolactone exhibits selective antitumor effects in HELA human cervical cancer cells.Oct 31, 2019

Pubmed Data : J BUON. 2019 Nov-Dec;24(6):2310-2315. PMID: 31983099
Article Published Date : Oct 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cervical Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest, NF-kappaB Inhibitor
Additional Keywords : Selective Antiproliferation
[+]

Alantolactone has potential to be used for the treatment of liver cancer.Nov 30, 2019

Pubmed Data : Artif Cells Nanomed Biotechnol. 2019 Dec ;47(1):1961-1970. PMID: 31116036
Article Published Date : Nov 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Alantolactone induces activation of apoptosis in human hepatoma cells.Aug 31, 2012

Pubmed Data : Food Chem Toxicol. 2012 Sep ;50(9):3313-9. Epub 2012 Jun 18. PMID: 22721982
Article Published Date : Aug 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Alantolactone induces apoptosis and improves chemosensitivity of pancreatic cancer cells.Dec 31, 2017

Pubmed Data : Toxicol Appl Pharmacol. 2018 10 1 ;356:159-171. Epub 2018 Aug 4. PMID: 30086361
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Pancreatic Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Oxaliplatin
[+]

Alantolactone induces apoptosis and suppresses migration in MCF‑7 human breast cancer cells.Sep 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2018 Oct ;42(4):1847-1856. Epub 2018 Jul 4. PMID: 30015828
Article Published Date : Sep 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor
[+]

Alantolactone induces apoptosis in chronic myelogenous leukemia sensitive or resistant to imatinib.Aug 31, 2013

Pubmed Data : Apoptosis. 2013 Sep ;18(9):1060-70. PMID: 23613107
Article Published Date : Aug 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction.Aug 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : IUBMB Life. 2012 Sep ;64(9):783-94. Epub 2012 Jul 27. PMID: 22837216
Article Published Date : Aug 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Glioblastoma
Pharmacological Actions : Antineoplastic Agents, Antioxidants, Antiproliferative , Apoptotic, NF-kappaB Inhibitor
[+]

Alantolactone induces apoptosis in THP-1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway.Dec 31, 2020

Pubmed Data : Chem Biol Drug Des. 2021 02 ;97(2):266-272. Epub 2020 Sep 5. PMID: 32780548
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Leukemia: Monocytic
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Alantolactone induces apoptosis of human cervical cancer cells.May 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2016 Jun ;11(6):4203-4207. Epub 2016 Apr 28. PMID: 27313767
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cervical Cancer
Pharmacological Actions : Bcl-2 protein down-regulation
[+]

Alantolactone induces G1 phase arrest and apoptosis of multiple myeloma cells and overcomes bortezomib resistance.Jul 31, 2015

Pubmed Data : Apoptosis. 2015 Aug ;20(8):1122-33. PMID: 26033479
Article Published Date : Jul 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Multiple Myeloma
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Alantolactone induces gastric cancer BGC-823 cell apoptosis.May 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2019 Jun ;17(6):4795-4802. Epub 2019 Mar 19. PMID: 31186685
Article Published Date : May 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic
[+]

Alantolactone inhibits breast cancer growth by antiangiogenic activity via blocking VEGFR2 signaling.Mar 31, 2018

Pubmed Data : Phytother Res. 2018 Apr ;32(4):643-650. Epub 2017 Dec 6. PMID: 29210118
Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Breast Cancer
Pharmacological Actions : Anti-Angiogenic
[+]

Alantolactone inhibits cell autophagy and promotes apoptosis via AP2M1 in acute lymphoblastic leukemia.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2020 ;20:442. Epub 2020 Sep 9. PMID: 32943990
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Acute lymphoblastic leukemia (ALL)
Pharmacological Actions : Apoptotic, Autophagy Inhibitors
[+]

Alantolactone inhibits cervical cancer progression by downregulating BMI1.Jan 28, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2021 04 29 ;11(1):9251. Epub 2021 Apr 29. PMID: 33927214
Article Published Date : Jan 28, 2021
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative
[+]

Alantolactone inhibits stem-like cell phenotype, chemoresistance and metastasis in PC3 cells.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Res Pharm Sci. 2020 Dec ;15(6):551-562. Epub 2020 Nov 27. PMID: 33828598
Article Published Date : Nov 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Prostate Cancer
Pharmacological Actions : Anti-metastatic, Tumor Suppressor Protein p53 Upregulation
[+]

Alantolactone may provide a useful therapeutic approach for inflammation-associated diseases. Nov 30, 2012

Pubmed Data : Int Immunopharmacol. 2012 Dec ;14(4):375-83. Epub 2012 Aug 28. PMID: 22940184
Article Published Date : Nov 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Alantolactone mitigates renal injury induced by diabetes.Mar 31, 2020

Pubmed Data : Immunopharmacol Immunotoxicol. 2020 Apr ;42(2):84-92. Epub 2020 Feb 16. PMID: 32064988
Article Published Date : Mar 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Renoprotective
[+]

Alantolactone plays neuroprotective roles in traumatic brain injury.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2018 ;10(2):368-380. Epub 2018 Feb 15. PMID: 29511431
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Brain Injury: Traumatic
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, NF-kappaB Inhibitor
[+]

Alantolactone selectively ablates acute myeloid leukemia stem and progenitor cells.Sep 21, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Hematol Oncol. 2016 Sep 22 ;9(1):93. Epub 2016 Sep 22. PMID: 27658462
Article Published Date : Sep 21, 2016
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Acute Myeloid Leukemia
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Cancer Stem Cells
[+]

Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells.Jan 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Lett. 2015 Feb 1 ;357(1):393-403. Epub 2014 Nov 27. PMID: 25434800
Article Published Date : Jan 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative , STAT3 Inhibitor
[+]

Alantolactone sensitizes human pancreatic cancer cells to EGFR inhibitors through the inhibition of STAT3 signaling.Dec 31, 2018

Pubmed Data : Mol Carcinog. 2019 04 ;58(4):565-576. Epub 2019 Jan 4. PMID: 30520143
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cancers: Drug Resistant, Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, STAT3 Inhibitor
[+]

Alantolactone suppresses human osteosarcoma through the PI3K/AKT signaling pathway.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2020 02 ;21(2):675-684. Epub 2019 Dec 13. PMID: 31974628
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells.Apr 21, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Respir Res. 2020 Apr 22 ;21(1):95. Epub 2020 Apr 22. PMID: 32321531
Article Published Date : Apr 21, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Lung Injury: Smoke-Induced, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Apoptotic, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Alantolactone suppresses the metastatic phenotype and induces the apoptosis of glioblastoma cells.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2021 05 ;47(5). Epub 2021 Mar 2. PMID: 33649781
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Glioblastoma
Pharmacological Actions : Anti-metastatic, Apoptotic
[+]

Alantolactone, a natural sesquiterpene lactone, has potent antitumor activity against glioblastoma.Jan 11, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2017 07 12 ;36(1):93. Epub 2017 Jul 12. PMID: 28701209
Article Published Date : Jan 11, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Glioblastoma
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Antioxidant and anticancer activities of extract of Inula helenium (L.) in human U-87 MG glioblastoma cell line.Mar 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer Res Ther. 2018 Apr-Jun;14(3):658-661. PMID: 29893335
Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Glioblastoma
Pharmacological Actions : Antioxidants, Antiproliferative
Additional Keywords : Plant Extracts
[+]

Antiproliferative sesquiterpene lactones from the roots of Inula helenium.Sep 30, 2002

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2002 Oct ;25(10):1370-2. PMID: 12392098
Article Published Date : Sep 30, 2002
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cervical Cancer, Melanoma
Pharmacological Actions : Antiproliferative
Additional Keywords : Plant Extracts
[+]

Antitumor activity of alantolactone in lung cancer cell lines NCI-H1299 and Anip973.Dec 31, 2018

Pubmed Data : J Food Biochem. 2019 09 ;43(9):e12972. Epub 2019 Jul 5. PMID: 31489665
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Lung Cancer
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix Metalloproteinase-7 (MMP-7) Inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Antitumour activities of sesquiterpene lactones from Inula helenium and Inula japonica.Jun 30, 2012

Pubmed Data : Z Naturforsch C J Biosci. 2012 Jul-Aug;67(7-8):375-80. PMID: 23016276
Article Published Date : Jun 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative
[+]

Apoptosis induction by alantolactone in breast cancer MDA-MB-231 cells.Feb 28, 2018

Pubmed Data : Arch Pharm Res. 2018 Mar ;41(3):299-313. Epub 2017 Dec 6. PMID: 29214600
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
[+]

Dual targeting EGFR and STAT3 with erlotinib and alantolactone co-loaded PLGA nanoparticles for pancreatic cancer treatment.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:625084. Epub 2021 Mar 19. PMID: 33815107
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Pancreatic Cancer
Pharmacological Actions : Apoptotic, STAT3 Inhibitor
[+]

Elecampane (Inula helenium) extracts exhibit highly selective cytotoxicity against tumor cell lines. May 01, 2010

Pubmed Data : Complement Ther Clin Pract. 2010 May;16(2):81-5. Epub 2009 Aug 19. PMID: 16912983
Article Published Date : May 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Tumors
Pharmacological Actions : Apoptotic
Additional Keywords : Plant Extracts, Selective Cytotoxicity
[+]

Elecampane (Inula helenium) extracts may have a therapeutic role in hypoxia. Apr 01, 2005

Pubmed Data : Bull Exp Biol Med. 2005 Apr;139(4):414-7. PMID: 16027868
Article Published Date : Apr 01, 2005
Study Type : Commentary
Additional Links
Substances : Elecampane
Diseases : Hypoxia
Additional Keywords : Plant Extracts
[+]

Elecampane (Inula helenium) has potent antisaphylococcal activity, including against MRSA, in vitro. Jan 01, 2009

Pubmed Data : Br J Biomed Sci. 2009;66(4):186-9. PMID: 20095126
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : MRSA
Pharmacological Actions : Anti-Bacterial Agents
[+]

Elecampane contains compounds with significant activity against Mycobacterium tubercolosis.May 01, 1999

Pubmed Data : Planta Med. 1999 May;65(4):351-5. PMID: 10364842
Article Published Date : May 01, 1999
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Mycobacterium Avium , Mycoplasma Infections
[+]

Enhancement of oxaliplatin-induced colon cancer cell apoptosis by alantolactone, a natural product inducer of ROS.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Sci. 2019 ;15(8):1676-1684. Epub 2019 Jun 4. PMID: 31360110
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Colon Cancer, Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Oxaliplatin
[+]

Ethanol extract of Inula helenium has anti-inflammatory effect via the induction of p38 MAPK-dependent HO-1 signaling pathway.Apr 30, 2013

Pubmed Data : Food Chem Toxicol. 2013 May ;55:386-95. Epub 2013 Jan 5. PMID: 23298677
Article Published Date : Apr 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Alcohol Toxicity , Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Ethyl acetate extract from Inula helenium L. inhibits the proliferation of pancreatic cancer cells by regulating the STAT3/AKT pathway.Mar 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2018 Apr ;17(4):5440-5448. Epub 2018 Feb 1. PMID: 29393456
Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Plant Extracts
[+]

Induction of ROS Overload by Alantolactone prompts oxidative DNA damage and apoptosis in colorectal cancer cells.Apr 13, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 Apr 14 ;17(4):558. Epub 2016 Apr 14. PMID: 27089328
Article Published Date : Apr 13, 2016
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic
[+]

Inhibition of growth of esophageal cancer by alantolactone.Jan 11, 2021

Pubmed Data : Anticancer Agents Med Chem. 2021 Jan 12. Epub 2021 Jan 12. PMID: 33438562
Article Published Date : Jan 11, 2021
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Esophageal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Wnt/β-catenin signaling pathway modulation
[+]

Inula L. secondary metabolites against oxidative stress-related human diseases.May 05, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 May 6 ;8(5). Epub 2019 May 6. PMID: 31064136
Article Published Date : May 05, 2019
Study Type : Review
Additional Links
Substances : Elecampane
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Isoalantolactone alleviates ovalbumin‑induced asthmatic inflammation.Sep 30, 2021

Pubmed Data : Mol Med Rep. 2021 Oct ;24(4). Epub 2021 Aug 9. PMID: 34368878
Article Published Date : Sep 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Asthma, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Isoalantolactone enhances the antimicrobial activity of penicillin G against Staphylococcus aureus.Feb 25, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pathogens. 2020 Feb 26 ;9(3). Epub 2020 Feb 26. PMID: 32110983
Article Published Date : Feb 25, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Antimicrobial
Additional Keywords : Natural Substance/Drug Synergy
[+]

Isoalantolactone enhances the radiosensitivity of UMSCC-10A cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(12):e0145790. Epub 2015 Dec 30. PMID: 26716456
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Radiosensitizer
[+]

Isoalantolactone from Inula helenium caused Nrf2-mediated induction of detoxifying enzymes.Sep 30, 2009

Pubmed Data : J Med Food. 2009 Oct ;12(5):1038-45. PMID: 19857067
Article Published Date : Sep 30, 2009
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Liver Cancer
Pharmacological Actions : Antioxidants, Chemopreventive, Detoxifier, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Isoalantolactone induces apoptosis in human breast cancer cells via ROS-mediated mitochondrial pathway and downregulation of SIRT1.Sep 30, 2016

Pubmed Data : Arch Pharm Res. 2016 Oct ;39(10):1441-1453. Epub 2016 Sep 6. PMID: 27600429
Article Published Date : Sep 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
[+]

Isoalantolactone induces apoptosis through reactive oxygen species-dependent upregulation of death receptor 5 in human esophageal cancer cells.Dec 31, 2017

Pubmed Data : Toxicol Appl Pharmacol. 2018 08 1 ;352:46-58. Epub 2018 May 22. PMID: 29800641
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Esophageal Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic
[+]

Isoalantolactone induces apoptosis through ROS-mediated ER stress and inhibition of STAT3 in prostate cancer cells.Dec 11, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2018 Dec 12 ;37(1):309. Epub 2018 Dec 12. PMID: 30541589
Article Published Date : Dec 11, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, STAT3 Inhibitor
[+]

Isoalantolactone induces autophagic cell death in SKOV3 human ovarian carcinoma cells via upregulation of PEA-15.Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2016 Feb ;35(2):833-40. Epub 2015 Nov 26. PMID: 26718904
Article Published Date : Jan 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative
[+]

Isoalantolactone induces intrinsic apoptosis through p53 signaling pathway in human lung squamous carcinoma cells.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(8):e0181731. Epub 2017 Aug 4. PMID: 28777796
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer, Squamous cell carcinoma
Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Sci. 2012 ;8(4):533-47. Epub 2012 Mar 28. PMID: 22532787
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Isoalantolactone inhibits esophageal squamous cell carcinoma growth.Dec 31, 2017

Pubmed Data : Dig Dis Sci. 2018 09 ;63(9):2285-2293. Epub 2018 May 21. PMID: 29781054
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Esophageal Cancer, Squamous cell carcinoma
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, MicroRNA modulator
[+]

Isoalantolactone inhibits LPS-induced inflammation via NF-κB inactivation in peritoneal macrophages and improves survival in sepsis.May 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Jun ;90:598-607. Epub 2017 Apr 11. PMID: 28407580
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Isoalantolactone inhibits pancreatic cancer proliferation by regulation of PI3K and Wnt signal pathway.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2021 ;16(3):e0247752. Epub 2021 Mar 4. PMID: 33661942
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin signaling pathway modulation
[+]

Isoalantolactone inhibits the migration and invasion of human breast cancer MDA-MB-231 cells.Aug 31, 2016

Pubmed Data : Oncol Rep. 2016 Sep ;36(3):1269-76. Epub 2016 Jul 20. PMID: 27461575
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Breast Cancer, Breast Cancer: Triple Negative , Cancer Metastasis
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
[+]

Isoalantolactone protects against Staphylococcus aureus pneumonia.Oct 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : FEMS Microbiol Lett. 2011 Nov ;324(2):147-55. Epub 2011 Sep 15. PMID: 22092816
Article Published Date : Oct 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Pneumonia, Staphylococcus aureus infection
Pharmacological Actions : Antimicrobial
Additional Keywords : Plant Extracts
[+]

Isoalantolactone protects LPS-induced acute lung injury through Nrf2 activation.Sep 30, 2018

Pubmed Data : Microb Pathog. 2018 Oct ;123:213-218. Epub 2018 Jul 19. PMID: 30009971
Article Published Date : Sep 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Isoalantolactone restores the sensitivity of gram-negative Enterobacteriaceae carrying MCR-1 to carbapenems.Dec 31, 2019

Pubmed Data : J Cell Mol Med. 2020 02 ;24(4):2475-2483. Epub 2020 Jan 19. PMID: 31957212
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Klebsiella Infections
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Isoalantolactone significantly inhibits K562/A02 cell proliferation mainly via caspase-dependent apoptotic pathway.Jan 31, 2017

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Feb ;25(1):110-114. PMID: 28245385
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
[+]

Nrf2-mediated induction of detoxifying enzymes by alantolactone present in Inula helenium.Oct 31, 2008

Pubmed Data : Phytother Res. 2008 Nov ;22(11):1500-5. PMID: 18702092
Article Published Date : Oct 31, 2008
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Oxidative Stress
Pharmacological Actions : Detoxifier, Enzyme Activators, Nrf2 activation, Phase II Detoxification Enzyme Inducer
Additional Keywords : Plant Extracts
[+]

Protective effect of total phenolic compounds from Inula helenium on hydrogen peroxide-induced oxidative stress in SH-SY5Y cells.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Indian J Pharm Sci. 2015 Mar-Apr;77(2):163-9. PMID: 26009648
Article Published Date : Feb 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Sesquiterpenoids from the roots of Inula helenium inhibit acute myelogenous leukemia progenitor cells.Dec 31, 2018

Pubmed Data : Bioorg Chem. 2019 05 ;86:363-367. Epub 2019 Jan 31. PMID: 30753990
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Plant Extracts
[+]

Sesquiterpenoids isolated from the flower of Inula japonica as potential antitumor leads for intervention of paclitaxel-resistant non-small-cell lung cancer.Dec 31, 2019

Pubmed Data : Bioorg Chem. 2020 08 ;101:103973. Epub 2020 May 24. PMID: 32521367
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antiproliferative , Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Targeting non-oncogene ROS pathway by alantolactone in B cell acute lymphoblastic leukemia cells.Jun 14, 2019

Pubmed Data : Life Sci. 2019 Jun 15 ;227:153-165. Epub 2019 Apr 17. PMID: 31004657
Article Published Date : Jun 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Acute lymphoblastic leukemia (ALL)
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

These findings provide an in-depth insight into the molecular mechanism of alantolactone in the treatment of lung cancer.Jan 23, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 07 24 ;7(1):6242. Epub 2017 Jul 24. PMID: 28740138
Article Published Date : Jan 23, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cancers: Drug Resistant, Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

These findings provide the potential of I. helenium as a promising phytomedicine for the treatment and prevention of triple-negative breast cancer.Nov 30, 2018

Pubmed Data : Phytother Res. 2018 Dec ;32(12):2501-2509. Epub 2018 Sep 24. PMID: 30251272
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic
Additional Keywords : Plant Extracts
[+]

Total sesquiterpene lactones prepared from Inula helenium L. has potentials in prevention and therapy of rheumatoid arthritis.Jan 19, 2017

Pubmed Data : J Ethnopharmacol. 2017 Jan 20 ;196:39-46. Epub 2016 Dec 15. PMID: 27988396
Article Published Date : Jan 19, 2017
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Arthritis, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Elecampane has an ancient history of medicinal use.Jan 01, 1998

Pubmed Data : Bull Indian Inst Hist Med Hyderabad. 1998 Jan;28(1):7-11. PMID: 12587579
Article Published Date : Jan 01, 1998
Additional Links
Substances : Elecampane
[+]

Elecampane induces detoxifying enzymes and may hold promise as a chemopreventive agent.Sep 01, 2007

Pubmed Data : J Med Food. 2007 Sep;10(3):503-10. PMID: 17887945
Article Published Date : Sep 01, 2007
Additional Links
Substances : Elecampane

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