Ellagic Acid

Name	AC	CK
Oxidative Stress	17	39
Insulin Resistance	6	35
Diabetes Mellitus: Type 2	7	27
Inflammation	10	22
Cervical Cancer	7	16
Prostate Cancer	7	16
Colon Cancer	11	15
Breast Cancer	9	13
Multiple Sclerosis	2	12
Cancers: All	11	11
Human Papillomavirus (HPV)	2	11
Chemically-Induced Liver Damage	5	10
Irritable Bowel Syndrome	1	10
Melasma	1	10
Neutropenia: Chemotherapy Induced	1	10
Polycystic Ovary Syndrome	1	10
Sleep Disorders	1	10
Testicular Injury: Chemical/Metal Induced	5	10
Chemotherapy-Induced Toxicity: Cisplatin	5	9
Colorectal Cancer	4	9
DNA damage	6	9
Diabetic Complications	5	9
Lipid Peroxidation	5	9
Parkinson's Disease	7	9
Alzheimer's Disease	5	8
Cognitive Decline/Dysfunction	4	8
Aging	5	7
Kidney Damage: Chemically-Induced	3	7
Liver Cancer	5	7
Ultraviolet Radiation Induced Damage	2	7
Benzo[a]pyrene-induced Toxicity	3	6
Chemotherapy-Induced Toxicity: Doxorubicin	3	6
Colitis	3	6
Dementia	3	6
Ischemia	3	6
Kidney Damage	3	6
Liver Damage	3	6
Lung Cancer	4	6
Traumatic Brain Injury	3	6
Acrylamide-induced toxicity	3	5
Arsenic Poisoning	3	5
Arthritis	2	5
Bladder Cancer	4	5
Hyperlipidemia	3	5
Lipopolysaccharide-Induced Toxicity	3	5
Neurodegenerative Diseases	4	5
Nonalcoholic fatty liver disease (NAFLD)	3	5
Oral Cancer	4	5
Ovarian Cancer	3	5
Pancreatic Cancer	5	5
Advanced Glycation End products (AGE)	3	4
Brain Inflammation	2	4
Breast Cancer: Triple Negative	2	4
Cataract	2	4
Cerebral Ischemia	2	4
Depression	2	4
Diabetes: Cognitive Dysfunction	2	4
Diabetic Nephropathy	2	4
Gastric Ulcer	2	4
Liver Injury: Ischemia/reperfusion	2	4
Memory Disorders	2	4
Myocardial Infarction	2	4
Osteoporosis	2	4
Paraquat Toxicity	2	4
Pesticide Toxicity	2	4
Radiation Induced Illness	2	4
Rheumatoid Arthritis	2	4
Seizures	2	4
Atherosclerosis	2	3
Chronic Kidney Disease (CKD)	1	3
Coronavirus Infection	3	3
Drug-Induced Toxicity: Methotrexate	2	3
Estrogen Dominance	2	3
Estrogen Dysregulation: 2/4/16 hydroxyestrone ratios	2	3
Glioblastoma	2	3
HIV Infections	3	3
Hyperglycemia	2	3
Melanoma	2	3
Metabolic Syndrome X	2	3
Nephropathy	1	3
Pancreatitis	2	3
Phthalate Toxicity	2	3
Prostatic Hyperplasia: Benign	1	3
Squamous cell carcinoma	2	3
Acid Reflux	1	2
Aflatoxicosis	1	2
Aging Skin	1	2
Aging: Brain	1	2
Air Pollution Linked Toxicity	1	2
Alcohol Toxicity	1	2
Alcoholic Liver Disease	1	2
Alopecia: Androgenic	1	2
Anxiety	1	2
Athletic Performance	1	2
Brain: Oxidative Stress	1	2
Cancer: Prostate	1	2
Cancers: Drug Resistant	2	2
Carcinoma: Non-Small-Cell Lung	1	2
Cardiovascular Diseases	1	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Chemotherapy-Induced Toxicity: Bleomycin	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Chronic Pain	1	2
Cirrhosis: Liver	1	2
Colitis: Ulcerative	1	2
Diabetes Mellitus: Type 1	1	2
Diabetes: Oxidative Stress	1	2
Drug Toxicity: Methotrexate	1	2
Drug-Induced Toxicity: Cyclosporine	1	2
Drug-Induced Toxicity: Indomethacin	1	2
Escherichia coli Infections	2	2
Esophageal Cancer	2	2
Gallstones	1	2
Gastric Cancer	2	2
Gastrointestinal Cancer	1	2
Gastrointestinal Hemorrhage	1	2
Helicobacter Pylori Infection	1	2
High Fat Diet	1	2
High Fructose Diet	1	2
Huntington Disease	1	2
Hyperalgesia	1	2
Hyperpigmentation	2	2
Hypertension	1	2
Hyperuricemia	1	2
Jaundice: Post-Hepatic/Obstructive	1	2
Kidney Failure: Chronic	1	2
Liver Damage: Drug-Induced	1	2
Liver Fibrosis	1	2
Lung Diseases	1	2
Lung Inflammation	1	2
Lymphoma	1	2
Melanoma: Metastatic	1	2
Memory Disorders: Drug-Induced	1	2
Memory Disorders: Sleep Deprivation Induced	1	2
Metabolic Diseases	1	2
Morphine Tolerance/Dependence	1	2
Mucositis	1	2
Muscle Atrophy	1	2
Neuroblastoma	2	2
Neuropathic Pain	1	2
Nickel Poisoning	1	2
Nicotine/Tobacco Toxicity	1	2
Organ Transplantation	1	2
Periodontitis	1	2
Prostate Cancer: Prevention	1	2
Skin Cancer	1	2
Sugar (Sucrose) Toxicity	1	2
Surgery: Abdominal	1	2
Ulcerative Colitis	1	2
Wound Healing	1	2
Acute Myeloid Leukemia	1	1
Allergic Rhinitis	1	1
Allergies	1	1
Asthma	1	1
Atopic Dermatitis	1	1
Benzene Toxicity	1	1
Cancers: Multi-Drug Resistant	1	1
Candida Infection	1	1
Cardiotoxicity: Chemotherapy-Induced	1	1
Chronic Obstructive Pulmonary Disease	1	1
Common Cold	1	1
Coronavirus Disease (Covid-19)	1	1
Diabetes Mellitus: Type 2: Prevention	1	1
Diphtheria	1	1
Ebola	1	1
Endometrial Cancer	1	1
Endometriosis	1	1
Endothelial Dysfunction	1	1
Gastrointestinal Inflammation	1	1
Heavy Metal Toxicity	1	1
Hepatitis C	1	1
Herpes Simplex Virus Type 2	1	1
Infertility: Male	1	1
Inflammatory Bowel Diseases	1	1
Lower Respiratory Infections	1	1
Malaria	1	1
Marburg Virus	1	1
Obesity	1	1
Otitis media	1	1
Pneumonia	1	1
Prion Diseases	1	1
Promyelocytic leukemia	1	1
Respiratory Diseases	1	1
Rhinovirus Infection	1	1
Scars	1	1
Skin Diseases: Photo-Aging	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Thyroid Cancer	1	1
Zika Virus	1	1

Name	AC	CK
Antioxidants	83	160
Anti-Inflammatory Agents	62	130
Tumor Necrosis Factor (TNF) Alpha Inhibitor	30	70
Neuroprotective Agents	34	58
Antiproliferative	37	49
Interleukin-6 Downregulation	22	46
Hepatoprotective	21	40
Apoptotic	29	36
Chemopreventive	13	30
Anticarcinogenic Agents	13	29
Interleukin-1 beta downregulation	14	29
NF-kappaB Inhibitor	16	28
Nrf2 activation	13	22
Renoprotective	10	22
Anti-Apoptotic	12	21
Malondialdehyde Down-regulation	11	21
Chemoprotective Agents	11	20
Gastrointestinal Agents	7	20
Insulin Sensitizers	2	20
Anti-metastatic	11	16
Cardioprotective	8	14
SIRT1 Activator	3	14
Matrix metalloproteinase-9 (MMP-9) inhibitor	8	11
Antiviral Agents	10	10
Cell cycle arrest	4	9
Gastroprotective	5	9
Hypoglycemic Agents	6	9
Matrix metalloproteinase-2 (MMP-2) inhibitor	6	9
Superoxide Dismutase Up-regulation	4	9
Wnt/β-catenin signaling pathway modulation	7	9
MicroRNA modulator	5	8
Antineoplastic Agents	6	7
Chemosensitizer	5	7
Cyclooxygenase 2 Inhibitors	5	7
Antimutagenic Agents	4	6
Catalase Up-Regulation	3	6
Cytoprotective	4	6
Radioprotective	3	6
Tumor Suppressor Protein p53 Upregulation	6	6
Chemotherapeutic	4	5
Hypolipidemic	3	5
Anti-Ulcer Agents	2	4
Anticonvulsants	2	4
Antidepressive Agents	2	4
Antinoceceptive	2	4
Osteoprotective	2	4
Radiosensitizer	4	4
Xanthine oxidase inhibitor	2	4
Antimicrobial	2	3
Autophagy Up-regulation	3	3
Bcl-2 protein down-regulation	2	3
Enzyme Inhibitors	3	3
Heme oxygenase-1 up-regulation	2	3
Interleukin-10 downregulation	1	3
Analgesics	1	2
Angiogenesis Inhibitors	1	2
Anti-Angiogenic	1	2
Anti-Anxiety Agents	1	2
Anti-Bacterial Agents	2	2
Anti-Fibrotic	2	2
Anti-atherogenic	1	2
Bax/Bcl2 ratio: Increase	1	2
Brain-derived neurotrophic factor modulator	1	2
Caspase-3 Activation	1	2
Chelating Agents	1	2
Cytotoxic	2	2
Estradiol Antagonists	1	2
Genoprotective	2	2
Glutathione Upregulation	1	2
Heme oxygenase-1 inducer	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	2
P21 Activation	2	2
Photoprotective	1	2
Protein Kinase Inhibitors	1	2
Proton Pump Inhibitor	1	2
Tyrosinase inhibitors	2	2
Vascular Endothelial Growth Factor Inhibitors	1	2
Vasodilator Agents	1	2
Anti-Allergic Agents	1	1
Anti-Glycation Agents	1	1
Anti-Retroviral Agents	1	1
Anti-bacterial	1	1
Antifungal Agents	1	1
Cyclooxygenase 1 Inhibitor	1	1
Glutathione S-transferase Inhibitor	1	1
HIV Protease Inhibitors	1	1
Immunomodulatory	1	1
Interferon Gamma Reducer	1	1
Nitric Oxide Inhibitor	1	1
Pancreato Protective Agents	1	1
Prostaglandin PGE2 downregulation	1	1
Quorum Sensing Inhibition	1	1
Reverse Transcriptase Inhibitors	1	1
STAT3 Inhibitor	1	1
Topoisomerase I inhibitor	1	1
Topoisomerase II Inhibitor	1	1
Transforming growth factor beta (TGF-β) inhibitor	1	1

[+]

Decreased insulin resistance in diabetic patients by influencing Sirtuin1 and Fetuin-A following supplementation with ellagic acid.Feb 04, 2021

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Pubmed Data : J Ovarian Res. 2021 Jul 31 ;14(1):100. Epub 2021 Jul 31. PMID: 34330312

Article Published Date : Jul 30, 2021

Study Type : Human Study

Additional Links

Substances : Ellagic Acid

Diseases : Insulin Resistance, Oxidative Stress, Polycystic Ovary Syndrome

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Ellagic acid supplementation can improve the health status of MS patients by reduction of the inflammatory cytokines.Dec 31, 2022

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Pubmed Data : J Cell Mol Med. 2020 Jul 12. Epub 2020 Jul 12. PMID: 32657027

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Pubmed Data : J Enzyme Inhib Med Chem. 2016 ;31(sup4):114-118. Epub 2016 Aug 23. PMID: 27555116

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid, Hesperidin

Diseases : Ischemia, Lipid Peroxidation

Pharmacological Actions : Antioxidants

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A enriched Mongolian oak cups extract could exert anti-diabetic effects through alleviating types 1 and 2 diabetes and their complications.Apr 29, 2018

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Pubmed Data : Environ Pollut. 2022 Jun 1 ;302:119048. Epub 2022 Feb 24. PMID: 35219795

Article Published Date : May 31, 2022

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid

Diseases : Chemically-Induced Liver Damage, Kidney Damage: Chemically-Induced, Oxidative Stress, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants

Problem Substances : Lead

[+]

Assessment of the protective effects of selected dietary anticarcinogens against DNA damage and cytogenetic effects induced by benzo[a]pyrene.Jul 31, 2011

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Pubmed Data : Food Chem Toxicol. 2011 Aug ;49(8):1674-83. Epub 2011 Mar 3. PMID: 21376772

Article Published Date : Jul 31, 2011

Study Type : Animal Study

Additional Links

Substances : Benzyl isothiocyanate , Catechin , Ellagic Acid

Diseases : Benzo[a]pyrene-induced Toxicity , DNA damage

Pharmacological Actions : Anticarcinogenic Agents

Additional Keywords : Isothiocyanates

Problem Substances : Benzo(a)pyrene

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Co-treatments with Uro-A decreased IC50 values for both 5-FU and 5'DFUR and additionally arrested the cell cycle at the G2/M phase.Apr 30, 2015

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Pubmed Data : Food Funct. 2015 May ;6(5):1460-9. PMID: 25857357

Article Published Date : Apr 30, 2015

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid, Urolithin A

Diseases : Colon Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Cell cycle arrest, Chemosensitizer

Additional Keywords : Drug: 5-flourouracil, Metabolites, Microbiota

[+]

Combination effects of ellagic acid with erlotinib in a Ba/F3 cell line expressing EGFR H773_V774 insH mutation.Dec 31, 2019

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Pubmed Data : Thorac Cancer. 2020 08 ;11(8):2101-2111. Epub 2020 Jun 11. PMID: 32525282

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Pubmed Data : PLoS One. 2012 ;7(4):e34628. Epub 2012 Apr 2. PMID: 22485181

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Chlorophyllin, Ellagic Acid

Diseases : Oral Cancer, Squamous cell carcinoma

Pharmacological Actions : Anticarcinogenic Agents

Additional Keywords : Gene Expression Regulation

[+]

Effect of ellagic acid on damage caused by hepatic ischemia reperfusion.Oct 31, 2022

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Ellagic acid alleviates rheumatoid arthritis.Dec 31, 2020

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Pubmed Data : Mediators Inflamm. 2021 ;2021:6359652. Epub 2021 Dec 9. PMID: 34924813

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Ellagic acid alleviates skin wrinkle and inflammation induced by UV-B irradiation.Jul 31, 2010

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[+]

Ellagic acid attenuates post-cerebral ischemia and reperfusion behavioral deficits.Apr 30, 2020

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Pubmed Data : Iran J Basic Med Sci. 2017 Apr ;20(4):399-407. PMID: 28804609

Article Published Date : Mar 31, 2017

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid

Diseases : Traumatic Brain Injury

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Ellagic acid could exert anti-angiogenesis effects via VEGFR-2 signalling pathway in breast cancer.Jul 31, 2012

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Pubmed Data : Environ Sci Pollut Res Int. 2019 Dec 29. Epub 2019 Dec 29. PMID: 31885062

Article Published Date : Dec 28, 2019

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid

Diseases : Lung Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Ellagic acid may provide a useful nutritional supplement to ameliorate features of metabolic syndrome.Feb 27, 2021

Ellagic acid protects rats from chronic renal failure via MiR-182/FOXO3a axis.Sep 30, 2021

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Pubmed Data : Mol Immunol. 2021 Oct ;138:150-160. Epub 2021 Aug 21. PMID: 34428620

Article Published Date : Sep 30, 2021

Study Type : Animal Study

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Substances : Ellagic Acid

Diseases : Kidney Failure: Chronic

Pharmacological Actions : MicroRNA modulator, Renoprotective

[+]

Ellagic acid provides protection against lead-induced nephrotoxicity to a significant degree.Dec 31, 2020

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Pubmed Data : Heliyon. 2021 Jan ;7(1):e05921. Epub 2021 Jan 8. PMID: 33490681

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Renoprotective

Problem Substances : Lead

[+]

Ellagic acid reverses alterations in the expression of AMPA Receptor and its scaffolding proteins in the cerebral cortex and memory decline.Jun 05, 2024

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Pubmed Data : Psychopharmacology (Berl). 2024 Jun 6. Epub 2024 Jun 6. PMID: 38842699

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Preventive effect of ellagic acid on cardiac dysfunction in diabetic mice.Feb 15, 2022

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Pubmed Data : J Agric Food Chem. 2022 Feb 16 ;70(6):1902-1910. Epub 2022 Feb 7. PMID: 35129965

Article Published Date : Feb 15, 2022

Study Type : Animal Study

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Substances : Ellagic Acid

Diseases : Diabetic Complications

Pharmacological Actions : Cardioprotective

[+]

Protective effects of ellagic acid against alcoholic liver disease.Dec 31, 2020

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Pubmed Data : Biomed Res Int. 2014 ;2014:467465. Epub 2014 May 14. PMID: 24949451

Article Published Date : Dec 31, 2013

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Pubmed Data : Cancer Prev Res (Phila). 2010 Feb;3(2):170-8. Epub 2010 Jan 26. PMID: 20103723

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Pubmed Data : Food Funct. 2023 Aug 14 ;14(16):7550-7561. Epub 2023 Aug 14. PMID: 37526638

Article Published Date : Aug 13, 2023

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid

Diseases : Colitis, Inflammation

Pharmacological Actions : Gastrointestinal Agents

Additional Keywords : Gene Expression Regulation

[+]

The ameliorative effect of ellagic acid on di-(2-ethylhexyl) phthalate-induced testicular structural alterations.Sep 17, 2021

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Pubmed Data : Surg Laparosc Endosc Percutan Tech. 2021 Nov 10 ;32(2):166-171. Epub 2021 Nov 10. PMID: 34753896

Article Published Date : Nov 09, 2021

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid

Diseases : Gallstones

Pharmacological Actions : Gastrointestinal Agents

[+]

The effects of ellagic acid on the prevention of peritoneal adhesion were found to be stronger than diclofenac sodium.Aug 31, 2014

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Pubmed Data : Int Surg. 2014 Sep-Oct;99(5):543-50. PMID: 25216418

Article Published Date : Aug 31, 2014

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Pubmed Data : Iran J Kidney Dis. 2016 Jan ;11(1):23-28. PMID: 28174349

Article Published Date : May 31, 2016

Study Type : Review

Additional Links

Substances : Ellagic Acid

Pharmacological Actions : Neuroprotective Agents

[+]

An ellagic acid derivative efficiently inhibits colon cancer cell growth through a mechanism involving WNT16.Apr 30, 2015

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Pubmed Data : J Pharmacol Exp Ther. 2015 May ;353(2):433-44. Epub 2015 Mar 10. PMID: 25758919

Article Published Date : Apr 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Ellagic Acid

Diseases : Cancers: Drug Resistant, Colon Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Wnt/β-catenin signaling pathway modulation

Additional Keywords : Drug: 5-flourouracil, Selective Antiproliferation

[+]

Anti-COVID-19 potential of ellagic acid and polyphenols of Punica granatum.Apr 26, 2023

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Pubmed Data : Molecules. 2023 Apr 27 ;28(9). Epub 2023 Apr 27. PMID: 37175181

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Pubmed Data : Biotechnol Appl Biochem. 2021 Nov 30. Epub 2021 Nov 30. PMID: 34846078

Article Published Date : Nov 29, 2021

Study Type : Review

Additional Links

Substances : Ellagic Acid

Diseases : Cancers: All

Pharmacological Actions : Chemotherapeutic

[+]

Ellagic acid can be considered as a potent agent that decreases cell proliferation.Sep 30, 2016

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Pubmed Data : Phytomedicine. 2022 Feb 18 ;99:153998. Epub 2022 Feb 18. PMID: 35217437

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Pubmed Data : Cell Physiol Biochem. 2017 ;41(6):2374-2382. Epub 2017 Apr 27. PMID: 28467979

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Ellagic Acid

Diseases : Endometrial Cancer

Pharmacological Actions : Antiproliferative

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Ellagic acid inhibits high glucose-induced injury in rat mesangial cells via the PI3K/Akt/FOXO3a signaling pathway.Aug 31, 2021

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Pubmed Data : Oncotarget. 2017 Jan 25. Epub 2017 Jan 25. PMID: 28135203

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Pubmed Data : Phytomedicine. 2015 Jan 15 ;22(1):213-22. Epub 2014 Dec 3. PMID: 25636891

Pubmed Data : Curr Pharm Des. 2016 ;22(10):1350-60. PMID: 26806345

Article Published Date : Dec 31, 2015

Study Type : Review

Additional Links

Substances : Ellagic Acid

Diseases : Neurodegenerative Diseases

Pharmacological Actions : Neuroprotective Agents

[+]

L. speciosa leaf extracts containing ellagic acid could be useful as an antiviral agent in the prevention or treatment of HRV infection.Dec 31, 2013

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Pubmed Data : Phytomedicine. 2023 Jan ;109:154582. Epub 2022 Nov 30. PMID: 36610130

Article Published Date : Dec 31, 2022

Study Type : Review

Additional Links

Substances : Citrus naringin, Curcumin, Ellagic Acid, Ginsenosides, Magnolol, Myricetin, Naringenin , Piperine, Resveratrol, Sulforaphane

Diseases : Alzheimer's Disease, Neurodegenerative Diseases, Parkinson's Disease

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation

[+]

Polyphenols in the Mediterranean diet: from dietary sources to microRNA modulation.Feb 22, 2021

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Pubmed Data : Antioxidants (Basel). 2021 Feb 23 ;10(2). Epub 2021 Feb 23. PMID: 33672251

Article Published Date : Feb 22, 2021

Study Type : Review

Additional Links

Substances : Apigenin, Ellagic Acid, Hesperidin, Kaempferol, Naringenin , Oleuropein, Polyphenols

Diseases : Cancers: All

Therapeutic Actions : Dietary Modification: Mediterranean Diet

Pharmacological Actions : Chemotherapeutic, MicroRNA modulator

[+]

Pomegranate contains four compounds ellagic acid, caffeic acid, luteolin and punicic acid, which inhibit prostate cancer cell invasion and have synergistic effects with one another. Mar 01, 2005

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Pubmed Data : Invest New Drugs. 2005 Mar;23(2):121-2. PMID: 15744587

Article Published Date : Mar 01, 2005

Study Type : In Vitro Study

Additional Links

Substances : Caffeic Acid, Ellagic Acid, Luteolin, Pomegranate, Punicic acid

Diseases : Prostate Cancer

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Pomegranate may offer an attractive dietary strategy for the prevention and treatment of AGE-related diseases such as type-2 diabetes and Alzheimer's disease.Oct 31, 2014

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Pubmed Data : Food Funct. 2014 Nov ;5(11):2996-3004. PMID: 25233108

Article Published Date : Oct 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Ellagic Acid, Pomegranate, Punicalagin, Tannic Acid

Diseases : Advanced Glycation End products (AGE), Alzheimer's Disease, Diabetes Mellitus: Type 2: Prevention

Pharmacological Actions : Antioxidants

Additional Keywords : Plant Extracts

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Pomegrante contains compounds with antiproliferative, apoptotic and antioxidant activites against various cancer cell lines. Jun 01, 2005

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Pubmed Data : J Nutr Biochem. 2005 Jun;16(6):360-7. PMID: 15936648

Rhodiola rosea has potent anti-filovirus properties that may be developed as a novel anti-Ebola treatment.Mar 26, 2018

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Ellagic acid demonstrates anticancer activity against colon, breast, lung and prostate cancer cells.Jun 01, 2006

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Pubmed Data : Chin J Integr Med. 2006 Jun;12(2):126-31. PMID: 15590271

Article Published Date : Jun 01, 2006

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Substances : Ellagic Acid

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Ellagic acid protects cultured rat embryos from the embryotoxic effects of n-methyl-N-nitorsourea.Dec 13, 1901

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Pubmed Data : Nephrol Dial Transplant. 2008 July; 23(7): 2133–2137. PMID: 8322221

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Substances : Ellagic Acid

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View the Evidence: 292 Abstracts with Ellagic Acid Research

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Decreased insulin resistance in diabetic patients by influencing Sirtuin1 and Fetuin-A following supplementation with ellagic acid.Feb 04, 2021

Ellagic acid effect on the components of metabolic syndrome, insulin sensitivity and insulin secretion.Sep 27, 2022

Ellagic acid significantly decreases the level of melanin in patients with melasma.Sep 01, 2008

Ellagic acid supplementation can be helpful as a diet supplement in patients with type 2 diabetes.Jan 31, 2021

Ellagic acid supplementation can be helpful as a diet supplement in women with PCOS through improvement in insulin resistance.Jul 30, 2021

Ellagic acid supplementation can improve the health status of MS patients by reduction of the inflammatory cytokines.Dec 31, 2022

Ellagic acid therapy reduces chemotherapy induced toxicity, e.g. neutropenia, in hormone refractory prostate cancer patients. Apr 01, 2005

Improving effect of ellagic acid on sleep quality and gastrointestinal symptoms in patient with irritable bowel syndrome.Jan 10, 2021

Women treated with the ellagic acid complex were less likely to be diagnosed with an abnormal Pap smear at 6 months.Feb 28, 2017

Ellagic acid plays a defensive role against UV-B-induced oxidative stress.Apr 30, 2016

These results provide important new data for ellagic acid in anti-colorectal carcinoma research.Jan 31, 2017

Ameliorative effect of traditional polyherbal formulation on TNF-α, IL-1β and Caspase-3 expression in kidneys.Jul 10, 2023

Ellagic acid improves benign prostate hyperplasia.Jun 16, 2022

Ellagic acid protects type II collagen induced arthritis.Sep 30, 2022

The nephroprotective effects of Hibiscus sabdariffa leaf and ellagic acid.Dec 22, 2022

Ellagic acid protects dopamine neurons from rotenone-induced neurotoxicity via activation of Nrf2 signalling Jul 11, 2020

The effect of ellagic acid on spinal cord and sciatica function in a mice model of multiple sclerosis.Jul 07, 2020

1,8 cineole and ellagic acid inhibit hepatocarcinogenesis.Dec 31, 2021

A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury.Dec 31, 2015

A enriched Mongolian oak cups extract could exert anti-diabetic effects through alleviating types 1 and 2 diabetes and their complications.Apr 29, 2018

Ameliorative effect of ellagic acid and Vitamin C against malathion-induced toxicity in testis.Jan 16, 2023

An ellagic acid enriched pomegranates extract promoted cholesterol removal by enhancing fecal bile acid.Feb 28, 2015

Anti-glycative and anti-inflammatory effects of caffeic acid and ellagic acid in kidney of diabetic mice.Feb 28, 2010

Anti-inflammatory effects of ellagic acid and vanillic acid against quinolinic acid-induced model of Huntington's disease.Nov 04, 2022

Antidepressant-like activity of ellagic acid in unstressed and acute immobilization-induced stressed mice.Dec 31, 2011

Antioxidative, anti-inflammatory and anti-apoptotic action of ellagic acid against lead acetate induced testicular and hepato-renal oxidative damages.May 31, 2022

Assessment of the protective effects of selected dietary anticarcinogens against DNA damage and cytogenetic effects induced by benzo[a]pyrene.Jul 31, 2011

Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism.Jun 01, 2010

Blueberry, black raspberry and ellagic acid significantly reduce tumor volume and multiplicity in estrogen-induced mammary carcinogenesis. - Article 1Jul 16, 2007

Caffeic acid and ellagic acid ameliorate adjuvant-induced arthritis.Jan 31, 2019

Central and peripheral antinociceptive effects of ellagic acid in different animal models of pain.May 04, 2013

Chemoprevention of mammary carcinogenesis by sustained systemic delivery of ellagic acid.Oct 31, 2011

Cloudberry and its compounds possess strong chemopreventive activity against colon cancer.May 29, 2016

Co-treatments with Uro-A decreased IC50 values for both 5-FU and 5'DFUR and additionally arrested the cell cycle at the G2/M phase.Apr 30, 2015

Combination effects of ellagic acid with erlotinib in a Ba/F3 cell line expressing EGFR H773_V774 insH mutation.Dec 31, 2019

Consumption of some polyphenols reduces fecal deoxycholic acid and lithocholic acid, the secondary bile acids of risk factors of colon cancer.Sep 23, 2009

Curcumin inhibits radiation-induced changes in the liver. Dec 01, 2001

Curcumin, ellagic acid and bixin attenuate radiation induced toxicity.Sep 01, 1996

Curcumin, ellagic acid and bixin provide protection against chromosome damage produced by radiation.Dec 01, 1998

dietary chlorophyllin and ellagic acid that can reverse gene expression signature associated with carcinogenesis.Dec 31, 2011

Effect of ellagic acid on damage caused by hepatic ischemia reperfusion.Oct 31, 2022

Effect of ellagic acid on seizure threshold in two acute seizure tests.Aug 09, 2021

EGCG and ellagic acid have protective effects on cataract development via the inhibition of oxidative stress.Dec 31, 2016

Ellagic acid alleviates hepatic ischemia-reperfusion injury in C57 mice via the caspase-1-GSDMD pathway.Jun 17, 2022

Ellagic acid alleviates motor, cognitive and hippocampal electrical activity deficits in occlusion cerebral ischemia/reperfusion.Dec 31, 2022

Ellagic acid alleviates oxidative stress by mediating Nrf2 signaling pathways and protects against paraquat-induced intestinal injury.Jan 26, 2022

Ellagic acid alleviates rheumatoid arthritis.Dec 31, 2020

Ellagic acid alleviates skin wrinkle and inflammation induced by UV-B irradiation.Jul 31, 2010

Ellagic acid ameliorated STZ-induced dementia by probably restoring the balance between cellular pro-oxidants and anti-oxidants in brain of rats.Jun 30, 2017

Ellagic acid ameliorates cisplatin induced hepatotoxicity in colon carcinogenesis.Apr 04, 2019

Ellagic acid ameliorates functionality of reverse cholesterol transport in murine model of atherosclerosis.Mar 31, 2024

Ellagic acid ameliorates high fructose-induced hyperuricemia and non-alcoholic fatty liver.Sep 14, 2022

Ellagic acid ameliorates nickel induced biochemical alterations: diminution of oxidative stress.Nov 01, 1999

Ellagic acid ameliorates paraquat-induced liver injury associated with improved gut microbial profile.Jan 14, 2022

Ellagic acid ameliorates renal function in experimental diabetic nephropathy.Aug 04, 2014

Ellagic acid ameliorates renal ischemic-reperfusion injury.Nov 25, 2019

Ellagic acid and its microbial metabolite urolithin A alleviate diet-induced insulin resistance in mice.Aug 10, 2020

Ellagic acid and pumpkin seed oil protects against methotrexate-induced small intestine damage in rats.Nov 30, 2011

Ellagic acid and rosmarinic acid attenuate doxorubicin-induced testicular injury in rats.Jun 05, 2017

Ellagic acid and rosmarinic acid can effectively protect against doxorubicin induced neurotoxicity.Aug 15, 2017

Ellagic acid application could be a useful memory restorative agent in the treatment of dementia seen in elderly persons.Jan 31, 2016

Ellagic acid attenuates bleomycin and cyclophosphamide-induced pulmonary toxicity.Jul 31, 2013

Ellagic acid attenuates muscle atrophy in STZ-induced diabetic mice.Aug 30, 2022

Ellagic acid attenuates post-cerebral ischemia and reperfusion behavioral deficits.Apr 30, 2020

Ellagic acid can be considered a promising antibacterial agent against H. pylori-associated gastroduodenal diseases in humans.Mar 15, 2018

Ellagic acid can effectively protect brain tissue against sodium arsenate-induced neurotoxicity.Mar 31, 2018

Ellagic acid can restore neurologic severity score, cognitive and long-term potentiation deficits and prevent brain inflammation.Mar 31, 2017

Ellagic acid could exert anti-angiogenesis effects via VEGFR-2 signalling pathway in breast cancer.Jul 31, 2012

Ellagic acid could protect against the testicular toxicity induced cyclosporine A in animals. Jul 17, 2016

Ellagic acid enhances morphine analgesia and attenuates the development of morphine tolerance and dependence.Oct 14, 2014

Ellagic acid enhances muscle endurance by affecting the muscle fiber type, mitochondrial biogenesis and function.Feb 06, 2022

Ellagic acid exerted protective effects against carbon tetrachloride-induced cirrhosis through the inhibition of ROS formation and angiogenesis.Sep 30, 2017

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View the Evidence:
292 Abstracts with Ellagic Acid Research