Emodin

Name	AC	CK
Pancreatic Cancer	7	11
Pancreatitis	6	11
Breast Cancer	9	10
Endometriosis	1	10
Lung Injury: Acute	6	10
Lupus Nephritis	1	10
Inflammation	6	9
Alzheimer's Disease	3	6
Coronavirus Infection	6	6
Lipopolysaccharide-Induced Toxicity	4	6
Osteoporosis	3	6
Cancers: Drug Resistant	4	5
Kidney Fibrosis	3	5
Liver Damage	3	5
Spondylitis: Ankylosing	1	5
Asthma	2	4
Cardiovascular Diseases	3	4
High Fat Diet	2	4
Liver Cancer	3	4
Melanoma	4	4
Neuropathic Pain	2	4
Oxidative Stress	3	4
Ulcerative Colitis	2	4
Cancer Metastasis	2	3
Cancers: All	3	3
Carcinoma: Non-Small-Cell Lung	3	3
Cervical Cancer	3	3
Colon Cancer	3	3
Colorectal Cancer	2	3
Coxsackievirus Infections	2	3
Kidney Damage	2	3
Liver Fibrosis	2	3
Oral Cancer	2	3
Organ Transplantation: Liver	2	3
Staphylococcus aureus infection	3	3
Acute Respiratory Distress Syndrome	1	2
Aging	1	2
Cadmium Poisoning	1	2
Cerebral Ischemia	1	2
Chemotherapy-Induced Toxicity: Cisplatin	2	2
Coronavirus Disease	2	2
Dementia	1	2
Diabetic Nephropathy	1	2
Encephalitis	1	2
Endothelial Dysfunction	1	2
Fibrosis	1	2
Foot and Mouth Disease	1	2
Glioblastoma	1	2
HIV Drug-Induced Toxicity	1	2
Hydrogen Peroxide Induced Toxicity	2	2
Hyperhomocysteinemia	1	2
Hyperlipidemia	1	2
Hypertension	1	2
Inflammatory Bowel Diseases	1	2
Influenza A	1	2
Leishmaniasis	1	2
Lung Inflammation	1	2
Membranoproliferative glomerulonephritis (MPGN)	1	2
Myocardial Fibrosis	1	2
Myocardial Infarction	1	2
Nerve Compression Syndromes	1	2
Pancreatic Cancer: Metastatic	1	2
Plasmodium Infections	2	2
Psoriasis	1	2
Sepsis	1	2
Skin Cancer	2	2
Systemic Lupus Erythematosus	1	2
Thyroid Cancer	1	2
Tongue Cancer	2	2
Adult T-cell leukemia/lymphoma (ATL)	1	1
Atherosclerosis	1	1
Brain Inflammation	1	1
Brain: Oxidative Stress	1	1
Candida Albicans	1	1
Chemotherapy-Induced Toxicity: Doxorubicin	1	1
Chronic Kidney Disease (CKD)	1	1
Chronic Myeloid Leukemia	1	1
Esophageal Cancer	1	1
Eye Injury: Chemical	1	1
Fluoride Toxicity	1	1
Gallbladder Cancer	1	1
Head and Neck Cancer	1	1
Helicobacter Pylori Infection	1	1
Hepatitis B	1	1
Human T-Cell Lymphotrophic Virus type 1 associated disease	1	1
Hypoxia	1	1
Ischemia	1	1
Leukemia: Chronic myelogenous leukemia (CML)	1	1
Liver Disease	1	1
Lung Cancer	1	1
Lymphoma	1	1
Melanoma: Metastatic	1	1
Mitochondrial Dysfunction	1	1
Multiple Myeloma	1	1
Nasopharyngeal Cancer	1	1
Osteoarthritis	1	1
Osteosarcoma	1	1
Ovarian Cancer	1	1
Pancreatitis: Acute Necrotizing	1	1
Peripheral Neuropathies	1	1
Prostate Cancer	1	1
Respiratory Syncytial Virus Infections	1	1
Severe Acute Respiratory Syndrome	1	1
Silicosis	1	1
Skin Cancer: Squamous Cell	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Stroke: Ischemic	1	1

Name	AC	CK
Anti-Inflammatory Agents	26	45
Apoptotic	30	38
Antiproliferative	23	27
Tumor Necrosis Factor (TNF) Alpha Inhibitor	12	22
Interleukin-1 beta downregulation	11	19
Chemosensitizer	14	18
Anti-Apoptotic	11	17
Antioxidants	9	14
NF-kappaB Inhibitor	8	13
Antiviral Agents	10	12
Interleukin-6 Downregulation	7	12
Anti-Fibrotic	7	11
Cardioprotective	6	11
Neuroprotective Agents	7	11
Anti-metastatic	8	10
Chemotherapeutic	8	10
MicroRNA modulator	6	9
Nrf2 activation	5	8
Renoprotective	5	8
Angiogenesis Inhibitors	4	7
Cell cycle arrest	6	6
Hypolipidemic	4	6
Osteoprotective	3	6
Antineoplastic Agents	5	5
Hepatoprotective	3	5
Analgesics	2	4
Interleukin-18 down-regulation	2	4
Gastroprotective	2	3
Heme oxygenase-1 up-regulation	2	3
Immunomodulatory	3	3
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	3
Transforming growth factor beta (TGF-β) inhibitor	3	3
Anti-Angiogenic	1	2
Anti-Asthmatic Agents	1	2
Anti-Bacterial Agents	2	2
Anticholesteremic Agents	1	2
Antimalarials	2	2
Antimicrobial	2	2
Autophagy Up-regulation	2	2
Bcl-2 protein down-regulation	1	2
Chemopreventive	2	2
Cyclooxygenase 2 Inhibitors	1	2
Enzyme Inhibitors	2	2
Gastrointestinal Agents	1	2
Heme oxygenase-1 inducer	1	2
Interleukin-8 downregulation	1	2
Leishmanicidal	1	2
Pancreato Protective Agents	1	2
Tumor Suppressor Protein p53 Upregulation	2	2
Vascular Endothelial Growth Factor A Inhibitor	1	2
Angiotensin II Type 1 Receptor Blockers	1	1
Antinoceceptive	1	1
Chemoprotective Agents	1	1
Cytoprotective	1	1
Glucose transporter-1 (GLUT1) expression down-regulation	1	1
Immunostimulatory	1	1
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	1
Nitric Oxide Inhibitor	1	1
Photosensitizing Agents	1	1
Postaglandin PGE2 downregulation	1	1
Protease Inhibitors	1	1
Radiosensitizer	1	1
Telomerase Inhibitor	1	1
Vascular Endothelial Growth Factor Regulator	1	1
Wnt/β-catenin signaling pathway modulation	1	1

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Pharmacological Actions : Anti-Bacterial Agents

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Pubmed Data : Med Sci Monit. 2019 Jul 29 ;25:5621-5629. Epub 2019 Jul 29. PMID: 31354164

Article Published Date : Jul 28, 2019

Study Type : Animal Study

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Substances : Emodin

Diseases : Asthma, Inflammation

Pharmacological Actions : Anti-Asthmatic Agents, Anti-Inflammatory Agents

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Emodin prevented depression in chronic unpredicted mild stress.Dec 31, 2020

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Pubmed Data : Biosci Rep. 2020 Jan 14. Epub 2020 Jan 14. PMID: 31934719

Article Published Date : Jan 13, 2020

Study Type : Animal Study

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Substances : Emodin

Diseases : Inflammatory Bowel Diseases, Osteoporosis

Pharmacological Actions : Gastrointestinal Agents, Osteoprotective

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The combination of emodin and sorafenib may offer a potential therapy for patients with advanced liver cancer.Oct 11, 2018

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Pubmed Data : J Pharm Biomed Anal. 2015 Nov 10 ;115:144-9. Epub 2015 Jun 23. PMID: 26201645

Article Published Date : Nov 09, 2015

Study Type : Animal Study

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Substances : Emodin, Piperine

Additional Keywords : Increased Bioavailability

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Treatment with emodin may repress angiogenesis in pancreatic cancer by altering the activities of the TGF-β/Smad pathway and angiogenesis-associated microRNAs. Jul 30, 2015

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Pubmed Data : Mol Med Rep. 2015 Jul 31. Epub 2015 Jul 31. PMID: 26238071

Article Published Date : Jul 30, 2015

Study Type : Animal Study

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Substances : Emodin

Diseases : Pancreatic Cancer

Pharmacological Actions : Angiogenesis Inhibitors, MicroRNA modulator

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Pubmed Data : Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1630-47. PMID: 16356126

Article Published Date : Nov 01, 2005

Study Type : Review

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Substances : Betulinic acid, Caffeic acid phenethyl ester, Curcumin, Emodin, Flavonoids, Genistein, Green Tea, Polyphenols, Resveratrol, Silymarin, Ursolic Acid

Diseases : Cancers: Drug Resistant

Pharmacological Actions : Chemosensitizer, Radiosensitizer

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A review of the anti-cancer natural products isolated from Chinese medicinal herbs.Jul 21, 2011

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Pubmed Data : Chin Med. 2011 Jul 22 ;6(1):27. Epub 2011 Jul 22. PMID: 21777476

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Pubmed Data : Oncol Rep. 2016 Mar 24. Epub 2016 Mar 24. PMID: 27035222

Article Published Date : Mar 23, 2016

Study Type : In Vitro Study

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Substances : Aloe Vera, Emodin

Diseases : Osteosarcoma

Therapeutic Actions : Integrative Medicine, Photodynamic therapy

Pharmacological Actions : Apoptotic, Autophagy Up-regulation

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Aloe emodin inhibits cancer cell growth in human pancreatic carcinoma cells.Feb 28, 2019

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Aloe-emodin enhances tamoxifen cytotoxicity in breast cancer cells.Feb 22, 2017

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Pubmed Data : Am J Chin Med. 2017 Feb 23:1-14. Epub 2017 Feb 23. PMID: 28231748

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Pubmed Data : Eur J Pharmacol. 2020 Nov 5 ;886:173550. Epub 2020 Sep 11. PMID: 32926915

Article Published Date : Nov 04, 2020

Study Type : In Vitro Study

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Substances : Aloe Vera, Emodin

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Apoptotic

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Aloe-emodin induces breast tumor cell apoptosis.Dec 31, 2019

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Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:5276832. Epub 2022 Feb 27. PMID: 35265148

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

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Substances : Emodin

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Apoptotic, Pancreato Protective Agents

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Emodin alleviates hydrogen peroxide-induced inflammation and oxidative stress.Dec 31, 2019

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Pubmed Data : Oncol Rep. 2020 Jan ;43(1):260-269. Epub 2019 Nov 19. PMID: 31746437

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

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Substances : Emodin

Diseases : Leukemia: Chronic myelogenous leukemia (CML)

Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin signaling pathway modulation

Additional Keywords : Natural Substance/Drug Synergy

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Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation.Sep 30, 2022

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Emodin reduces the activity of (1,3)-β-D-glucan synthase from Candida albicans and does not interact with caspofungin.Dec 31, 2017

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Pubmed Data : Pol J Microbiol. 2018 ;67(4):463-470. PMID: 30550232

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

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Substances : Emodin

Diseases : Candida Albicans

Pharmacological Actions : Antimicrobial

Additional Keywords : Natural Substance/Drug Synergy

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Emodin regulates the autophagy via the miR-371a-5p/PTEN axis to inhibit hepatic malignancy.Jun 06, 2022

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Pubmed Data : Biochem Biophys Res Commun. 2022 Jun 7 ;619:1-8. Epub 2022 Jun 7. PMID: 35724456

Article Published Date : Jun 06, 2022

Study Type : In Vitro Study

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Substances : Emodin

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Chemopreventive, MicroRNA modulator

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Pubmed Data : Neurotox Res. 2020 Sep 15. Epub 2020 Sep 15. PMID: 32930996

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Pubmed Data : J Infect Public Health. 2020 Oct 14. Epub 2020 Oct 14. PMID: 33109497

Article Published Date : Oct 13, 2020

Study Type : In Vitro Study

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Substances : Emodin, False Black Pepper

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

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Photodynamic therapy with aloe emodin effectively suppressed cancer development in MCF-7cells.Aug 19, 2015

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Pubmed Data : Anticancer Agents Med Chem. 2015 Aug 20. Epub 2015 Aug 20. PMID: 26295333

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Pubmed Data : Bioorg Chem. 2017 Sep 18 ;75:217-223. Epub 2017 Sep 18. PMID: 28987877

Article Published Date : Sep 17, 2017

Study Type : In Vitro Study

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Substances : Emodin

Diseases : Plasmodium Infections

Pharmacological Actions : Antimalarials

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The extracts of Aloe vera collected from colder climatic regions showed good antiplasmodial activity.Jul 16, 2017

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This review aims to describe a timely overview of emodin related to the treatment of cardiovascular disease.Dec 31, 2019

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View the Evidence: 222 Abstracts with Emodin Research

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Emodin inhibits the migration and invasion abilities of human endometrial stromal cells.Dec 31, 2019

Emodin may improve interstitial fibrosis, thus improving prognosis of lupus nephritis. Mar 01, 2000

Emodin induces apoptosis and autophagy of fibroblasts obtained from patient with ankylosing spondylitis.Dec 31, 2018

Brain-targeting emodin mitigates ischemic stroke.Jun 27, 2023

Emodin combined with multiple-low-frequency, low-intensity ultrasound to relieve osteomyelitis through sonoantimicrobial chemotherapy. Oct 25, 2022

Emodin exerts a protective effect in CVB3-mediated encephalitis in HFMD by inhibiting the TLR3 pathway.Jul 05, 2020

Emodin promotes fibroblast apoptosis and prevents epidural fibrosis through PERK pathway in rats.Oct 09, 2019

Emodin reverses 5-Fu resistance in human colorectal cancer via downregulation of PI3K/Akt signaling pathway.Dec 31, 2019

Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.Dec 31, 2019

A natural compound mixture ameliorates psoriasis-like skin lesions.Dec 31, 2019

Aloe emodin reduces cardiac inflammation induced by a high-fat diet.Dec 31, 2019

Aloe emodin relieves Ang II-induced endothelial junction dysfunction.Nov 30, 2020

Aloe-emodin ameliorated myocardial infarction-induced cardiac remodeling.May 31, 2023

Aloe-emodin ameliorates diabetic nephropathy.Dec 31, 2021

Aloe-emodin attenuates myocardial infarction and apoptosis via up-regulating miR-133 expression.Jul 31, 2019

Aloe-emodin derivative produces anti-atherosclerosis effect by reinforcing AMBRA1-mediated endothelial autophagy.Feb 04, 2022

Aloe-emodin exerts cholesterol-lowering effects by inhibiting proprotein convertase subtilisin/kexin type 9.Mar 17, 2020

Aloe-emodin relieves zidovudine-induced injury.Dec 31, 2020

aloe-emodin showed antileishmanial effects under in vitro and in vivo conditions and may be used in clinical trials. Mar 31, 2015

Aloe-emodin suppresses oxidative stress and inflammation.Dec 31, 2021

Effect of emodin on hyperlipidemia and hepatic lipid metabolism.Dec 04, 2021

Effects of aloe emodin on U87MG glioblastoma cell growth.Oct 31, 2018

Emodin alleviated LPS-induced pulmonary inflammation in rat lung tissues.Mar 31, 2020

Emodin alleviated pancreatic and intestinal mucosa injury in experimental severe acute pancreatitis.Aug 14, 2017

Emodin alleviates aortic valvular calcification by inhibiting the AKT/FOXO1 pathway.Dec 23, 2021

Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts.Jun 30, 2019

Emodin alleviates gemcitabine resistance in pancreatic cancer.Oct 31, 2020

Emodin alleviates intestinal barrier dysfunction by inhibiting apoptosis and regulating the immune response in severe acute pancreatitis.Aug 31, 2021

Emodin alleviates LPS-induced inflammatory response in lung injury rat by affecting the function of granulocytes.Dec 31, 2019

Emodin alleviates LPS-induced myocardial injury through inhibition of NLRP3 inflammasome activation.Jun 15, 2021

Emodin alleviates severe acute pancreatitis-associated acute lung injury.Dec 31, 2020

Emodin ameliorates intestinal dysfunction by maintaining intestinal barrier integrity and modulating the microbiota in sepsis.Dec 31, 2021

Emodin ameliorates ovalbumin-induced airway remodeling in mice by suppressing airway smooth muscle cells proliferation.Oct 31, 2020

Emodin ameliorates renal damage and podocyte injury in a model of diabetic nephropathy.Dec 31, 2020

Emodin ameliorates renal injury in BXSB mice by modulating TNF-α/ICAM-1.Jan 29, 2020

Emodin ameliorates tubulointerstitial fibrosis in obstructed kidneys by inhibiting EZH2.Dec 31, 2020

Emodin attenuates acetaminophen-induced hepatotoxicity via the cGAS-STING pathway.Aug 17, 2021

Emodin attenuates acute lung injury in Cecal-ligation and puncture rats.Jul 31, 2020

Emodin attenuates inflammation and demyelination in experimental autoimmune encephalomyelitis.Jun 30, 2023

Emodin attenuates LPS-induced acute lung injury. Nov 16, 2021

Emodin attenuates severe acute pancreatitis via antioxidant and anti-inflammatory activity.Nov 30, 2019

Emodin can alleviate sepsis-induced lung injury in vivo and in vitro through regulation of SIRT1.Nov 21, 2021

Emodin exerts anti-metastatic activity in pancreatic cancer both in vitro and in vivo. Nov 01, 2011

Emodin extends lifespan of Caenorhabditis elegans.Sep 30, 2017

Emodin improves alveolar hypercoagulation and fibrinolytic inhibition and depresses excessive pulmonary inflammation in ARDS.Oct 31, 2020

Emodin improves itestinal health and immunity through modulation of gut microbiota.Nov 18, 2021

Emodin in Rheum undulatum inhibits oxidative stress in the liver.Nov 30, 2020

Emodin inhibited influenza A virus replication and influenza viral pneumonia.Oct 17, 2017

Emodin inhibits aggregation of amyloid-β peptide 1-42 and improves cognitive deficits in Alzheimer's disease.Aug 15, 2020

Emodin inhibits lipid accumulation and inflammation in adipose tissue of high-fat diet-fed mice.Jun 30, 2021

Emodin inhibits NF-κB signaling pathway to protect obese asthmatic rats from pathological damage via Visfatin.Jan 31, 2022

Emodin inhibits the proliferation of papillary thyroid carcinoma by activating AMPK .Sep 30, 2021

Emodin interferes with nitroglycerin-induced migraine. Dec 31, 2020

Emodin may be an efficient candidate natural product for severe acute pancreatitis treatment.Nov 01, 2018

Emodin may serve as a promising candidate for the treatment of Alzheimer's disease.Jan 31, 2021

Emodin might be a promising therapeutic agent for allergic asthma.Jul 28, 2019

Emodin prevented depression in chronic unpredicted mild stress.Dec 31, 2020

Emodin prevents renal ischemia-reperfusion injury.Nov 14, 2021

Emodin promotes autophagy and prevents apoptosis in sepsis-associated encephalopathy.Dec 05, 2021

Emodin protects against acute pancreatitis-associated lung injury.Dec 31, 2019

Emodin protects against intestinal and lung injury induced by acute intestinal injury.Jan 29, 2020

Emodin protects against lipopolysaccharide-induced acute lung injury.Dec 31, 2021

Emodin protects knee joint cartilage.Mar 14, 2021

Emodin protects sepsis associated damage to the intestinal mucosal barrier through the VDR/ Nrf2 /HO-1 pathway.Dec 31, 2020

Emodin reduces hepatocellular apoptosis following orthotopic liver transplantation in rats. Apr 01, 2008

Emodin reduces inflammatory and nociceptive responses in different pain and inflammation-induced mouse models.May 13, 2022

Emodin reduces tumor burden by diminishing M2-like macrophages in colorectal cancer.Jan 11, 2022

Emodin represents a novel potential candidate agent for hyperhomocysteinemia-induced dementia and Alzheimer's disease-like features.Nov 07, 2018

Emodin reverses resistance to gemcitabine in pancreatic cancer.Dec 31, 2022

Emodin sensitizes human pancreatic cancer cells to EGFR inhibitor through suppressing Stat3 signaling pathway.Dec 31, 2018

Emodin showed excellent hepatoprotective effects against lipopolysaccharide-induced acute liver injury.Dec 31, 2017

Emodin stimulates pancreatic regeneration in acute pancreatitis in rats. Nov 01, 2008

Emodin

View the Evidence:
222 Abstracts with Emodin Research