Enterolactone

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10 Diseases Researched for Enterolactone

Name	AC	CK	Focus
Breast Cancer	5	16
Breast Cancer: Prevention	4	15
Prostate Cancer	3	12
Fibroids: Uterine	1	10
Prostate Cancer: Prevention	1	10
Lupus Nephritis	1	2
Breast Cancer: Male	1	1
Cancers: All	1	1
Colon Cancer	1	1
Estrogen Dominance	1	1

9 Pharmacological Actions Researched for Enterolactone

Name	AC	CK	Focus
Antiproliferative	4	15
Vascular Endothelial Growth Factor A Inhibitor	2	12
Chemopreventive	2	11
Antineoplastic Agents	2	4
Aromatase Inhibitors	2	2
Anticarcinogenic Agents	1	1
Matrix metalloproteinase-14 (MMP-14) inhibitor	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1

Research Articles 12
Cumulative Knowledge Score 19
Overall Research Rating GOOD

View the Evidence:
12 Abstracts with Enterolactone Research

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[+]

Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer.Mar 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Med Food. 2013 Apr ;16(4):357-60. PMID: 23566060

Article Published Date : Mar 31, 2013

Study Type : Human Study

Additional Links

Substances : Enterolactone, Flaxseed, Lignans

Diseases : Prostate Cancer, Prostate Cancer: Prevention

Pharmacological Actions : Antiproliferative , Chemopreventive, Vascular Endothelial Growth Factor A Inhibitor

Additional Keywords : Phytotherapy, Plant Extracts

[+]

High dietary intakes of plant lignans and high exposure to enterolignans were associated with reduced risks of ER- and PR-positive postmenopausal breast cancer. Mar 21, 2007

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Pubmed Data : J Natl Cancer Inst. 2007 Mar 21;99(6):475-86. PMID: 17374837

Article Published Date : Mar 21, 2007

Study Type : Human Study

Additional Links

Substances : Enterodiol, Enterolactone, Flaxseed, Lignans, phytoestrogens

Diseases : Breast Cancer, Breast Cancer: Prevention

Additional Keywords : Risk Reduction

[+]

There is a modest inverse association between lignan excretion and uterine fibroid risk. Jan 01, 2005

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Pubmed Data : Cytotechnology. 2005 Jan;47(1-3):97-105. PMID: 16960173

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Substances : Daidzein, Enterodiol, Enterolactone, Equol, Genistein, Isoflavones, Lignans

Diseases : Fibroids: Uterine

[+]

Enterolactone and enterodiol have been shown to negate the tumor-stimulating effect of genistein in a mouse model of breast cancer.Jul 01, 2007

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Pubmed Data : Mol Nutr Food Res. 2007 Jul;51(7):845-56. PMID: 17579892

Article Published Date : Jul 01, 2007

Study Type : Animal Study

Additional Links

Substances : Enterodiol, Enterolactone, Flaxseed, Genistein, Isoflavones, Lignans, phytoestrogens, Soy Protein

Diseases : Breast Cancer, Breast Cancer: Prevention

Pharmacological Actions : Antineoplastic Agents, Antiproliferative

[+]

Flaxseed and its lignans have potent antiestrogenic effects on estrogen receptor-positive breast cancer and may prove to be beneficial in breast cancer prevention strategies in the future.Feb 01, 2007

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Pubmed Data : Clin Cancer Res. 2007 Feb 1;13(3):1061-7. PMID: 17289903

Article Published Date : Feb 01, 2007

Study Type : Animal Study

Additional Links

Substances : Enterodiol, Enterolactone, Flaxseed, Lignans

Diseases : Breast Cancer, Breast Cancer: Prevention

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Vascular Endothelial Growth Factor A Inhibitor

[+]

The lignan precursor from flaxseed known as secoisolariresinol diglucoside (SDG) may inhibit the progression of lupus nephritis. Jan 01, 2000

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Pubmed Data : Lupus. 2000;9(6):429-36. PMID: 10981647

Article Published Date : Jan 01, 2000

Study Type : Animal Study

Additional Links

Substances : Enterodiol, Enterolactone, Flaxseed, Lignans, Secoisolariciresinol diglucoside (SDG)

Diseases : Lupus Nephritis

[+]

Dietary lignans reduce breask cancer risk. Jul 01, 2007

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Pubmed Data : Mol Nutr Food Res. 2007 Jul;51(7):857-66. PMID: 17576639

Article Published Date : Jul 01, 2007

Study Type : Review

Additional Links

Substances : Enterodiol, Enterolactone, Lignans

Diseases : Breast Cancer: Prevention

Pharmacological Actions : Chemopreventive

[+]

Enterolactone, a mammalian lignan derived from flax lignan, down-regulates processes in breast cancer cells associated with metastasis.Dec 31, 2011

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Pubmed Data : Indian J Cancer. 2012 Jan-Mar;49(1):181-7. PMID: 22842186

Article Published Date : Dec 31, 2011

Study Type : In Vitro Study

Additional Links

Substances : Enterolactone

Diseases : Breast Cancer: Male

Pharmacological Actions : Matrix metalloproteinase-14 (MMP-14) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Mammalian lignans and the soy isoflavone genistein inhibit breast cancer via down-regulation of estrogen production. Apr 01, 2005

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Pubmed Data : J Steroid Biochem Mol Biol. 2005 Apr;94(5):461-7. Epub 2005 Mar 16. PMID: 15876411

Article Published Date : Apr 01, 2005

Study Type : In Vitro Study

Additional Links

Substances : Enterodiol, Enterolactone, Genistein, Lignans

Diseases : Breast Cancer, Estrogen Dominance

Pharmacological Actions : Aromatase Inhibitors

[+]

Mammalian lignans formed as a byproduct of flaxseed consumption inhibit prostate cancer cell growth. Nov 01, 2001

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Pubmed Data : Anticancer Res. 2001 Nov-Dec;21(6A):3995-9. PMID: 11911282

Article Published Date : Nov 01, 2001

Study Type : In Vitro Study

Additional Links

Substances : Enterodiol, Enterolactone, Flaxseed, Lignans

Diseases : Prostate Cancer

Pharmacological Actions : Anticarcinogenic Agents

[+]

Mammalian lignans inhibit the growth of estrogen-independent human colon tumor cells.May 01, 1998

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Pubmed Data : Anticancer Res. 1998 May-Jun;18(3A):1405-8. PMID: 9673348

Article Published Date : May 01, 1998

Study Type : In Vitro Study

Additional Links

Substances : Enterodiol, Enterolactone, Flaxseed, Lignans

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative

[+]

The mammalian phytoestrogens enterodiol and enterolactone may protect against breast and prostate cancer through hormone modulating activities.Sep 25, 2002

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Pubmed Data : J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Sep 25;777(1-2):289-309. PMID: 12270221

Article Published Date : Sep 25, 2002

Study Type : Review

Additional Links

Substances : Enterodiol, Enterolactone, Flaxseed, Lignans, phytoestrogens, Secoisolariciresinol diglucoside (SDG)

Diseases : Breast Cancer, Cancers: All, Prostate Cancer

Pharmacological Actions : Aromatase Inhibitors

Copyright: chassenet / 123RF Stock Photo

Research Articles 12
Cumulative Knowledge Score 19
Overall Research Rating GOOD

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