EPA (Eicosapentaenoic Acid)

Name	AC	CK
Inflammation	18	88
Depression	7	74
Diabetes Mellitus: Type 2	6	72
Cardiovascular Diseases	8	55
Bipolar Disorder	5	50
IgA Nephropathy	6	44
Hepatitis C	4	40
Huntington Disease	3	40
Omega-3 Fatty Acid Deficiency	4	40
C-Reactive Protein	3	30
Cognitive Decline/Dysfunction	3	30
Coronary Artery Disease	2	30
Depressive Disorder	2	30
Oxidative Stress	3	30
Peripheral Arterial Disease	3	30
Obesity	7	29
Breast Cancer	6	27
Adiponectin: Low Levels	4	23
Diabetes Mellitus: Type 1	2	22
Arterial Hardening: Elasticity	2	20
Attention Deficit Disorder with Hyperactivity	2	20
Depressive Syndrome	1	20
Heart Disease	1	20
Hyperlipidemia	2	20
Intermittent Claudication	2	20
Lupus Erythematosus: Systemic	2	20
Myocardial Infarction	1	20
Myocardial Infarction: Prevention	1	20
Prediabetes	1	20
Psoriatic Arthritis	2	20
Atherosclerosis	4	14
Rheumatoid Arthritis	3	13
Cystic Fibrosis	2	12
Fatty Liver	2	12
Gallstones	2	12
Hypertension	2	12
Osteoarthritis	2	12
Overweight	2	12
Asthma	2	11
Autoimmune Diseases	2	11
Glaucoma	2	11
Psoriasis	2	11
All-Cause Mortality	1	10
Allergic Rhinitis	1	10
Aneurysm: Cerebral	1	10
Angina Pectoris with Normal Coronary Arteriogram	1	10
Anorexia	1	10
Apolipoprotein Disorders	1	10
Arterial Plaque	1	10
Arteriosclerosis	1	10
Attention Deficit Disorder	1	10
Autism	1	10
Barrett Esophagus	1	10
Bladder Stones	1	10
Borderline Personality Disorder	1	10
Breast Cancer: Prevention	1	10
Breast Milk: Inadequate/Poor Quality	1	10
Carotid Stenosis	1	10
Cerebral Aneurysm	1	10
Cerebral Vasospasm	1	10
Childhood Cognitive Disorders	1	10
Cholesterol: Oxidation	1	10
Chronic Obstructive Pulmonary Disease	1	10
Colon Surgery	1	10
Colorectal Cancer	1	10
Coronavirus Disease (Covid-19)	1	10
Depression	1	10
Diabetes: Cardiovascular Illness	1	10
Elderly: Age Specific Diseases	1	10
Headache: Migraine	1	10
High Fat Diet	5	10
Kidney Failure	1	10
Kidney Stones	1	10
Lupus Nephritis	1	10
Mania: Acute	1	10
Mortality: All-Cause	1	10
Muscle Damage	1	10
Muscle Damage: Exercise-Induced	1	10
Muscle Soreness	1	10
Osteoporosis	1	10
Pancreatic Cancer	1	10
Periodontal Wound Healing	1	10
Periodontitis	1	10
Peripheral Vascular Diseases	1	10
Prenatal Nutrition: Health of the Offspring	1	10
Prostate Cancer	1	10
Prostate: PSA Doubling	1	10
Psychotic Disorders	1	10
Spinal Cord Inflammation	1	10
Spinal Cord Injuries	1	10
Systemic Lupus Erythematosus	1	10
Testosterone: Too High	1	10
Vasospasm: Intracranial	1	10
Aneurysm: Aortic	3	6
Insulin Resistance	3	6
Aortic Calcification	1	4
Ectopic Calcification	1	4
Liver Damage	2	4
Nephrocalcinosis	1	4
Sepsis	2	4
Alzheimer's Disease	2	3
Acute Myeloid Leukemia	1	2
Acute Myeloid Leukemia: Stem Cell	1	2
Amyotrophic Lateral Sclerosis	1	2
Arthritis	1	2
Brain Inflammation	1	2
Cancer Metastasis	1	2
Cancers: All	1	2
Catecholamines: Elevated	1	2
Cholestasis	1	2
Demyelinating Diseases	1	2
Dry Eye Syndromes	1	2
Endothelial Dysfunction	1	2
Endotoxemia	1	2
Epilepsy	1	2
Epinepherine-induced Disorders	1	2
Eye Diseases	1	2
Hyperuricemia	1	2
Lipid Peroxidation	1	2
Liver Steatosis	1	2
Muscle Atrophy	1	2
Muscle Trauma/Injury	1	2
Neurodegenerative Diseases	2	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Parkinson's Disease	2	2
Pulmonary Fibrosis	1	2
Pulmonary Hypertension	1	2
Ultraviolet Radiation Induced Damage	1	2
Uveitis	1	2
Cancers: Drug Resistant	1	1
Cancers: Multi-Drug Resistant	1	1
Chronic Kidney Disease (CKD)	1	1
Colon Cancer	1	1
Hemodialysis	1	1
Immune Dysregulation: TH1/TH2 imbalance	1	1
Immune Function: TH2 dominance	1	1
Inflammatory Bowel Diseases	1	1
Liver Cancer	1	1
Lymphoma: Mantle Cell	1	1
Neuroblastoma	1	1
Osteosarcoma	1	1
Ovarian Cancer	1	1
Thrombosis	1	1
Pressure Ulcer	1	0

Name	AC	CK
Anti-Inflammatory Agents	24	121
Antidepressive Agents	6	72
Neuroprotective Agents	7	55
Cardioprotective	10	49
Tumor Necrosis Factor (TNF) Alpha Inhibitor	4	34
Chemopreventive	3	22
Cyclooxygenase 2 Inhibitors	3	21
Adiponectin upregulation	1	20
Renoprotective	2	20
Hypoglycemic Agents	5	17
Apoptotic	4	15
Interleukin-6 Downregulation	3	14
Antioxidants	7	12
Interleukin-1 beta downregulation	2	12
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	12
Hypolipidemic	2	11
Anti-thrombotic	1	10
Antihypertensive Agents	1	10
Antipsychotic Agents	1	10
Interleukin-1 alpha downregulation	1	10
Anti-atherogenic	4	6
Hepatoprotective	3	6
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	6
NF-kappaB Inhibitor	3	6
Antiproliferative	3	4
Immunomodulatory	2	3
Anti-Adipogenic	1	2
Anti-Proliferative	1	2
Anti-metastatic	1	2
Antineoplastic Agents	1	2
Antioxidant Effects	2	2
Chemosensitizer	2	2
Glucagon Like peptide 1 (GLP-1) Up-regulation	1	2
Immunostimulatory	1	2
Lipolytic	1	2
Nitric Oxide Enhancer	1	2
Nrf2 activation	1	2
Superoxide Dismutase Up-regulation	1	2
Anti-Angiogenic	1	1
Anti-Arrhythmia Agents	1	1
Brain-derived neurotrophic factor modulator	1	1
Cardiovascular Agents	1	1
Caspase-3 Activation	1	1
Caspase-9 Activation	1	1
Cell cycle arrest	1	1
Gastrointestinal Agents	1	1
Gastroprotective	1	1
Tumor Suppressor Protein p53 Upregulation	1	1

[+]

Efficacy of ethyl-EPA as a treatment for Huntington disease.Mar 19, 2019

Click here to read the entire abstract

Pubmed Data : Acta Neuropsychiatr. 2019 Mar 20:1-38. Epub 2019 Mar 20. PMID: 30890195

Article Published Date : Mar 19, 2019

Study Type : Meta Analysis, Review

Additional Links

Substances : EPA (Eicosapentaenoic Acid)

Diseases : Huntington Disease

Pharmacological Actions : Neuroprotective Agents

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Eicosapentaenoic acid and docosahexaenoic acid supplementation may increase adiponectin and reduce TNF-α levels.Mar 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Diabetes Metab J. 2018 Apr ;42(2):101-116. PMID: 29676540

Article Published Date : Mar 31, 2018

Study Type : Meta Analysis, Review

Additional Links

Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid), Omega-3 Fatty Acids

Diseases : Diabetes Mellitus: Type 2, Prediabetes

Pharmacological Actions : Adiponectin upregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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"Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women."Sep 30, 2002

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2002 Oct ;88(4):411-20. PMID: 12323090

Article Published Date : Sep 30, 2002

Study Type : Human Study

Additional Links

Substances : ALA (Alpha-Linolenic Acid), DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid), Omega-3 Fatty Acids

Diseases : Omega-3 Fatty Acid Deficiency

Additional Keywords : Gender Differences, Gender Differences: Fatty Acid Metabolism, Omega-3 Fatty Acid Metabolism

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4-week eicosapentaenoic acid-rich fish oil supplementation partially protects muscular damage following eccentric contractions.Feb 28, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Int Soc Sports Nutr. 2021 Mar 1 ;18(1):18. Epub 2021 Mar 1. PMID: 33648546

Article Published Date : Feb 28, 2021

Study Type : Human Study

Additional Links

Substances : EPA (Eicosapentaenoic Acid), Fish Oil

Diseases : Muscle Damage: Exercise-Induced

Therapeutic Actions : Exercise

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A "very low dose" of omega-3 fatty acids slows renal progression in high-risk patients with IgA nephropathy.Jul 01, 2004

Click here to read the entire abstract

Pubmed Data : Ren Fail. 2004 Jul;26(4):453-9. PMID: 15462115

Pubmed Data : Am J Clin Nutr. 2007 Apr;85(4):1142-7. PMID: 17413117

Article Published Date : Apr 01, 2007

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid), Omega-3 Fatty Acids

Diseases : Cognitive Decline/Dysfunction, Elderly: Age Specific Diseases

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Risk Reduction

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Adjunctive ethyl-EPA is an effective and well-tolerated intervention in bipolar depression.Mar 01, 2005

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005 Mar;25(3):222-4. PMID: 16388069

Article Published Date : Mar 01, 2005

Study Type : Human Study

Additional Links

Substances : EPA (Eicosapentaenoic Acid)

Diseases : Bipolar Disorder

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Alpha-lipoic acid or in combination with eicosapentaenoic acid modulates the inflammatory status of healthy overweight or obese women.Mar 08, 2016

Click here to read the entire abstract

Pubmed Data : J Nutr. 2016 Mar 9. Epub 2016 Mar 9. PMID: 26962183

Article Published Date : Mar 08, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Cardiol. 2016 Nov 9 ;228:173-179. Epub 2016 Aug 9. PMID: 27865182

Article Published Date : Nov 08, 2016

Study Type : Human Study

Click here to read the entire abstract

Pubmed Data : Nutrition. 2005 Oct;21(10):1010-7. PMID: 16157238

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EPA is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability.Sep 01, 2010

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Pubmed Data : Atherosclerosis. 2010 Sep;212(1):252-9. Epub 2010 May 20. PMID: 20542512

Article Published Date : Sep 01, 2010

Study Type : Human Study

Additional Links

Substances : EPA (Eicosapentaenoic Acid)

Diseases : Angina Pectoris with Normal Coronary Arteriogram, Arterial Plaque, Atherosclerosis, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

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EPA may increase the efficacy and/or reduce ribavirin-associated hemolytic anemia in patients being treated for chronic hepatitic C virus infection. Jan 01, 2007

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Pubmed Data : Intervirology. 2007;50(6):439-46. Epub 2008 Feb 4. PMID: 18253048

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Pubmed Data : Chem Biol Interact. 2008 Nov 25;176(2-3):121-8. Epub 2008 Aug 3. PMID: 17629918

Article Published Date : Nov 25, 2008

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid)

Diseases : Attention Deficit Disorder with Hyperactivity

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EPO and EPO/fish oil produce a subjective improvement in rheumatoic arthritis patients and allow some patients to reduce or stop treatment with NSAIDsJan 31, 1988

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Pubmed Data : Ann Rheum Dis. 1988 Feb ;47(2):96-104. PMID: 2833184

Article Published Date : Jan 31, 1988

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Pubmed Data : J Nutr. 2010 Dec 22. Epub 2010 Dec 22. PMID: 21178081

Article Published Date : Dec 22, 2010

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid), Eicosapentaenoic acid (EPA) , Fish

Diseases : Breast Cancer: Prevention, Mortality: All-Cause

Additional Keywords : Whole Food is Superior to the Isolated Parts

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In this intervention, n-3 PUFAs significantly improved functioning and reduced psychiatric symptoms compared with placebo.Jun 30, 2013

Click here to read the entire abstract

Pubmed Data : Can J Psychiatry. 2013 Jul ;58(7):402-8. PMID: 23870722

Article Published Date : Jun 30, 2013

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid), Omega-3 Fatty Acids, Vitamin E

Diseases : Borderline Personality Disorder, Psychotic Disorders

Pharmacological Actions : Antipsychotic Agents

Additional Keywords : Significant Treatment Outcome

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Intake of eicosapentaenoic and docosahexaenoic acids from fish may be associated with a reduced prevalence of allergic rhinitis.Jun 01, 2007

Click here to read the entire abstract

Pubmed Data : J Am Coll Nutr. 2007 Jun;26(3):279-87. PMID: 17634174

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Nurs Midwifery Res. 2015 May-Jun;20(3):334-9. PMID: 26120333

Article Published Date : Apr 30, 2015

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid), Omega-3 Fatty Acids

Diseases : Headache: Migraine, Omega-3 Fatty Acid Deficiency

Additional Keywords : Risk Factors, Risk Reduction

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Multi-nutrient supplementation improved cognition and mobility in able older females at clinically relevant levels.Jan 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Gerontol A Biol Sci Med Sci. 2016 Feb ;71(2):236-42. Epub 2015 Aug 11. PMID: 26265727

Article Published Date : Jan 31, 2016

Study Type : Human Study

Additional Links

Substances : EPA (Eicosapentaenoic Acid), Folic Acid , Ginkgo biloba, Omega-3 Fatty Acids, Phosphatidylserine, Vitamin B-12, Vitamin E: alpha tocopherol

Diseases : Cognitive Decline/Dysfunction

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

Additional Keywords : Natural Substance Synergy

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Omega 3 fatty acids induce a marked reduction of apolipoprotein B48 when added to fluvastatin in patients with type 2 diabetes and mixed hyperlipidemia.Aug 01, 2010

Click here to read the entire abstract

Pubmed Data : Genes Cancer. 2010 Aug 1;1(8):868-876. PMID: 19133114

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Click here to read the entire abstract

Pubmed Data : J Natl Cancer Inst. 1995 Apr 19;87(8):587-92. PMID: 7752256

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2010 Jun 25;636(1-3):108-13. Epub 2010 Mar 27. PMID: 20347779

Article Published Date : Jun 25, 2010

Study Type : Animal Study

Additional Links

Substances : EPA (Eicosapentaenoic Acid)

Diseases : Endothelial Dysfunction, Pulmonary Hypertension

Pharmacological Actions : Nitric Oxide Enhancer

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Eicosapentaenoic acid minimized saturated fat-induced insulin resistance in mice.Oct 31, 2010

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Article Publish Status : This is a free article. Click here to read the complete article.

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EPA supplementation was effective in a murine model of acute myeloid leukemia. Aug 18, 2015

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Pubmed Data : Cancer Prev Res (Phila). 2015 Aug 19. Epub 2015 Aug 19. PMID: 26290393

Article Published Date : Aug 18, 2015

Study Type : Animal Study

Additional Links

Substances : EPA (Eicosapentaenoic Acid)

Diseases : Acute Myeloid Leukemia, Acute Myeloid Leukemia: Stem Cell

Pharmacological Actions : Chemopreventive

Additional Keywords : Cancer Stem Cells

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Fish oil being rich in EPA was effective in reversing the changes induced by obesity.Feb 25, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Int Urol Nephrol. 2004;36(4):591-8. PMID: 19211925

Article Published Date : Jan 01, 2004

Study Type : Animal Study

Additional Links

Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid), Omega-3 Fatty Acids

Diseases : Adiponectin: Low Levels, Fatty Liver, Insulin Resistance, Obesity

Pharmacological Actions : Hypoglycemic Agents

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Omega-3 fatty acids compares favorably with rosiglitazone for improving insulin sensitivity in mice fed a high-fat diet. May 01, 2009

Click here to read the entire abstract

Pubmed Data : Diabetologia. 2009 May;52(5):941-51. Epub 2009 Mar 11. PMID: 19277604

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Can Fam Physician. 2023 Jul ;69(7):459-468. PMID: 37452000

Article Published Date : Apr 19, 2023

Study Type : In Vitro Study

Additional Links

Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid), Vitamin K

Pharmacological Actions : Gastrointestinal Agents, Gastroprotective

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This review describes the anti-inflammatory and antioxidant effects of oxidized omega-3 fatty acids.Jan 01, 2016

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Pubmed Data : Biochimie. 2016 Jan ;120:56-61. Epub 2015 Jun 23. PMID: 26112019

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Res Int. 2015 ;2015:535189. Epub 2015 Aug 2. PMID: 26301248

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

EPA (Eicosapentaenoic Acid) is a Sub of the following Topic

View the Evidence: 153 Abstracts with EPA (Eicosapentaenoic Acid) Research

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Effect of omega-3 polyunsaturated fatty acids on cardiovascular outcomes in patients with diabetes.Jun 30, 2023

Efficacy of ethyl-EPA as a treatment for Huntington disease.Mar 19, 2019

Eicosapentaenoic acid and docosahexaenoic acid supplementation may increase adiponectin and reduce TNF-α levels.Mar 31, 2018

Eicosapentaenoic and docosahexaenoic acid may be associated with reducing coronary heart disease risk.Dec 31, 2016

Higher plasma concentrations of EPA and DPA are associated with a lower risk of nonfatal myocardial infarction among women. Jul 01, 2008

Omega-3 PUFA is effective in patients with diagnosis of major depressive disorder. Dec 31, 2013

The present analysis supports the hypothesis that dietary n-3 PUFA intake are associated with lower risk of depression.Aug 15, 2016

These results indicate a beneficial effect of the combination of EPA and DHA on depressed mood in women compared with placebo. Dec 31, 2014

"Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women."Sep 30, 2002

4-week eicosapentaenoic acid-rich fish oil supplementation partially protects muscular damage following eccentric contractions.Feb 28, 2021

A "very low dose" of omega-3 fatty acids slows renal progression in high-risk patients with IgA nephropathy.Jul 01, 2004

A 12-month therapy with omega-3 fatty acids improves renal vascular function and tubule function in IgA nephropathy patients.Sep 01, 2004

A combination of GLA and EPA may have therapeutic value in peripheral arterial disease. Dec 01, 1998

A deficiency of omega-3 fatty acids may play a role in the pathophysiology of bipolar disorder in children and adolescents. Nov 01, 2008

A high-fat meal enriched with eicosapentaenoic acid reduces postprandial arterial stiffness in healthy men. Feb 01, 2008

A moderate intake of EPA and DHA may postpone cognitive decline in elderly men. Apr 01, 2007

Adjunctive ethyl-EPA is an effective and well-tolerated intervention in bipolar depression.Mar 01, 2005

Alpha-lipoic acid or in combination with eicosapentaenoic acid modulates the inflammatory status of healthy overweight or obese women.Mar 08, 2016

An 8-month treatment with omega-3 fatty acids (EPA and DHA) has a positive effects, such as decreasing inflammation, in patients with cystic fibrosis. Jan 01, 2003

Dietary supplements containing EPA, GLA or CoQ10 may significantly affect serum PSA levels.Nov 29, 2012

Differential effects of high dose omega-3 fatty acids on metabolism and inflammation in patients with obesity.Dec 31, 2022

Early initiation of treatment with EPA combined with statin after successful primary PCI reduced cardiovascular events after ACS.Nov 08, 2016

Eicosapentaenoic acid (EPA) may exert beneficial effects on lupus nephritis by decreasing oxidative stress. Aug 01, 2006

Eicosapentaenoic acid (EPA) reduces the progression of carotid intima-media thickness in patients with type 2 diabetes. Mar 01, 2007

Eicosapentaenoic acid supplementation may be useful in therapy for chronic hepatitis C. Apr 01, 2008

Eicosapentaenoic acid supplements attenuate age-related increases in arterial stiffness in patients with dyslipidemiaAug 01, 2005

Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young menSep 30, 2002

Eight-week EPA + DHA supplementation attenuates strength loss and limited range of motion after exercise.Apr 15, 2016

Eiocosapentaenoic acid significantly reduces brain atrophy in Huntington's disease. Sep 01, 2008

Emotion-related network reorganization following fish oil supplementation in depressed bipolar offspring.Dec 31, 2020